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1. National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio:a pooled analysis of 458 population-based studies in Asian and Western countries

Author: Taddei, C. (Cristina), Jackson, R. (Rod), Zhou, B. (Bin), Bixby, H. (Honor), Danaei, G. (Goodarz), Di Cesare, M. (Mariachiara), Kuulasmaa, K. (Kari), Hajifathalian, K. (Kaveh), Bentham, J. (James), Bennett, J. E. (James E.), Aekplakorn, W. (Wichai), Cifkova, R. (Renata), Dallongeville, J. (Jean), DeBacquer, D. (Dirk), Giampaoli, S. (Simona), Gudnason, V. (Vilmundur), Khang, Y.-H. (Young-Ho), Laatikainen, T. (Tiina), Mann, J. I. (Jim, I), Marques-Vidal, P. (Pedro), Mensah, G. A. (George A.), Mueller-Nurasyid, M. (Martina), Ninomiya, T. (Toshiharu), Petkeviciene, J. (Janina), Rodriguez-Artalejo, F. (Fernando), Servais, J. (Jennifer), Soderberg, S. (Stefan), Stavreski, B. (Bill), Wilsgaard, T. (Tom), Zdrojewski, T. (Tomasz), Zhao, D. (Dong), Stevens, G. A. (Gretchen A.), Savin, S. (Stefan), Cowan, M. J. (Melanie J.), Riley, L. M. (Leanne M.), Ezzati, M. (Majid), Adams, R. J. (Robert J.), Ahrens, W. (Wolfgang), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Anderssen, S. A. (Sigmund A.), Ariansen, I. (Inger), Arveiler, D. (Dominique), Aspelund, T. (Thor), Auvinen, J. (Juha), Avdicova, M. (Maria), Banach, M. (Maciej), Bandosz, P. (Piotr), Banegas, J. R. (Jose R.), Barbagallo, C. M. (Carlo M.), Bata, I. (Iqbal), Baur, L. A. (Louise A.), Beaglehole, R. (Robert), Bernotiene, G. (Gailute), Bi, Y. (Yufang), Bienek, A. (Asako), Bjorkelund, C. (Cecilia), Bo, S. (Simona), Boehm, B. O. (Bernhard O.), Bonaccio, M. (Marialaura), Bongard, V. (Vanina), Borchini, R. (Rossana), Borghs, H. (Herman), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Bruno, G. (Graziella), Busch, M. A. (Markus A.), Cabrera de Leon, A. (Antonio), Capuano, V. (Vincenzo), Casanueva, F. F. (Felipe F.), Casas, J.-P. (Juan-Pablo), Caserta, C. A. (Carmelo A.), Censi, L. (Laura), Chen, F. (Fangfang), Chen, S. (Shuohua), Chirlaque, M.-D. (Maria-Dolores), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Claessens, F. (Frank), Clarke, J. (Janine), Clays, E. (Els), Cooper, C. (Cyrus), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Crujeiras, A. B. (Ana B.), Cui, L. (Liufu), D'Arrigo, G. (Graziella), Dauchet, L. (Luc), De Backer, G. (Guy), De Bacquer, D. (Dirk), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Dennison, E. (Elaine), Deschamps, V. (Valerie), Di Castelnuovo, A. (Augusto), Dobson, A. J. (Annette J.), Donfrancesco, C. (Chiara), Doering, A. (Angela), Drygas, W. (Wojciech), Du, Y. (Yong), Dziankowska-Zaborszczyk, E. (Elzbieta), Eggertsen, R. (Robert), Ekelund, U. (Ulf), Elosua, R. (Roberto), Eriksson, J. G. (Johan G.), Evans, A. (Alun), Faeh, D. (David), Felix-Redondo, F. J. (Francisco J.), Fernandez-Berges, D. (Daniel), Ferrari, M. (Marika), Ferrieres, J. (Jean), Finn, J. D. (Joseph D.), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Frontera, G. (Guillermo), Fujita, Y. (Yuki), Gaciong, Z. (Zbigniew), Galvano, F. (Fabio), Gao, J. (Jingli), Garcia-de-la-Hera, M. (Manoli), Garnett, S. P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Gianfagna, F. (Francesco), Gill, T. K. (Tiffany K.), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Goltzman, D. (David), Gonzalez Gross, M. (Marcela), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dusan), Gregor, R. D. (Ronald D.), Grodzicki, T. (Tomasz), Grosso, G. (Giuseppe), Gruden, G. (Grabriella), Gu, D. (Dongfeng), Guallar-Castillon, P. (Pilar), Gudmundsson, E. F. (Elias F.), Guessous, I. (Idris), Gunnlaugsdottir, J. (Johanna), Gutzwiller, F. (Felix), Hardy, R. (Rebecca), Hata, J. (Jun), Haugsgjerd, T. (Teresa), Hayes, A. J. (Alison J.), He, J. (Jiang), He, Y. (Yuna), Herrala, S. (Sauli), Hihtaniemi, I. T. (Ilpo Tapani), Hobbs, M. (Michael), Hopman, W. M. (Wilma M.), Maria Huerta, J. (Josi), Huybrechts, I. (Inge), Iacoviello, L. (Licia), Iannone, A. G. (Anna G.), Ikeda, N. (Nayu), Iwasaki, M. (Masanori), Jamrozik, K. (Konrad), Janszky, I. (Imre), Jarvelin, M.-R. (Marjo-Riitta), Jasienska, G. (Grazyna), Jennings, G. (Garry), Jeong, S.-L. (Seung-Lyeal), Jiang, C. Q. (Chao Qiang), Joffres, M. (Michel), Jokelainen, J. J. (Jari J.), Jonas, J. B. (Jost B.), Jozwiak, J. (Jacek), Kajantie, E. O. (Eero O.), Kauhanen, J. (Jussi), Keil, U. (Ulrich), Keinanen-Kiukaanniemi, S. (Sirkka), Kersting, M. (Mathilde), Kiechl-Kohlendorfer, U. (Ursula), Kiechl, S. (Stefan), Kim, J. (Jeongseon), Kim, Y.-Y. (Yeon-Yong), Klumbiene, J. (Jurate), Knoflach, M. (Michael), Ko, S. (Stephanie), Kolle, E. (Elin), Korpelainen, R. (Raija), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Kratzer, W. (Wolfgang), Kriemler, S. (Susi), Krokstad, S. (Steinar), Kujala, U. M. (Urho M.), Kurjata, P. (Pawel), Lam, T. H. (Tai Hing), Lanska, V. (Vera), Lappas, G. (Georg), Laugsand, L. E. (Lars E.), Lee, J. (Jeonghee), Lehtimaki, T. (Terho), Li, Y. (Yanping), Lilly, C. L. (Christa L.), Lin, X. (Xu), Lind, L. (Lars), Lissner, L. (Lauren), Liu, J. (Jing), Lopez-Garcia, E. (Esther), Lorbeer, R. (Roberto), Eugenio Lozano, J. (Jose), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lundqvist, R. (Robert), Lytsy, P. (Per), Ma, G. (Guansheng), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D. J. (Dianna J.), Manzato, E. (Enzo), Mathiesen, E. B. (Ellisiv B.), McLachlan, S. (Stela), McLean, R. M. (Rachael M.), McLean, S. B. (Scott B.), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Metcalf, P. (Patricia), Mi, J. (Jie), Miller, J. C. (Jody C.), Moreno, L. A. (Luis A.), Morin, S. N. (Suzanne N.), Mossakowska, M. (Malgorzata), Muiesan, M. L. (Maria L.), Mursu, J. (Jaakko), Nakamura, H. (Harunobu), Namesna, J. (Jana), Nauck, M. (Matthias), Maria Navarrete-Munoz, E. (Eva), Neal, W. A. (William A.), Nenko, I. (Ilona), Niiranen, T. J. (Teemu J.), Ning, G. (Guang), Noale, M. (Marianna), Norie, S. (Sawada), Noto, D. (Davide), O'Neill, T. (Terence), O'Reilly, D. (Dermot), Oh, K. (Kyungwon), Olafsson, O. (Orn), Paccaud, F. M. (Fred Michel), Pajak, A. (Andrzej), Palmieri, L. (Luigi), Panza, F. (Francesco), Parnell, W. R. (Winsome R.), Peltonen, M. (Markku), Peters, A. (Annette), Petersmann, A. (Astrid), Pigeot, I. (Iris), Pilotto, L. (Lorenza), Piwonska, A. (Aleksandra), Plans-Rubio, P. (Pedro), Porta, M. (Miquel), Price, J. F. (Jacqueline F.), Puder, J. J. (Jardena J.), Puhakka, S. E. (Soile E.), Radisauskas, R. (Ricardas), Raitakari, O. (Olli), Ramos, R. (Rafel), Redon, J. (Josep), Rigo, F. (Fernando), del Cristo Rodriguez-Perez, M. (Maria), Romaguera, D. (Dora), Ronkainen, K. (Kimmo), Rosengren, A. (Annika), Roy, J. G. (Joel G. R.), Ruidavets, J.-B. (Jean-Bernard), Rutkowski, M. (Marcin), Salanave, B. (Benoit), Salmeron, D. (Diego), Salomaa, V. (Veikko), Salonen, J. T. (Jukka T.), Salvetti, M. (Massimo), Sans, S. (Susana), Saramies, J. L. (Jouko L.), Saum, K.-U. (Kai-Uwe), Scheidt-Nave, C. (Christa), Schienkiewitz, A. (Anja), Schipf, S. (Sabine), Schmidt, C. O. (Carsten O.), Schoettker, B. (Ben), Sebert, S. (Sylvain), Sen, A. (Abhijit), Shaw, J. E. (Jonathan E.), Shibuya, K. (Kenji), Shin, D. W. (Dong Wook), Shiri, R. (Rahman), Simons, J. (Judith), Simons, L. A. (Leon A.), Sjostrom, M. (Michael), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Soumare, A. (Aicha), Staessen, J. A. (Jan A.), Stathopoulou, M. G. (Maria G.), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stieber, J. (Jutta), Stoeckl, D. (Doris), Stokwiszewski, J. (Jakub), Sundstrom, J. (Johan), Suriyawongpaisal, P. (Paibul), Tamosiunas, A. (Abdonas), Tan, E. J. (Eng Joo), Taylor, A. (Anne), Tell, G. (Grethe), Thijs, L. (Lutgarde), Tolonen, H. K. (Hanna K.), Topor-Madry, R. (Roman), Jose Tormo, M. (Maria), Torrent, M. (Maties), Tsugane, S. (Shoichiro), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Tzourio, C. (Christophe), Uusitalo, H. M. (Hannu M. T.), Van Herck, K. (Koen), Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Veronesi, G. (Giovanni), Vioque, J. (Jesus), Virtanen, J. K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Vollenweider, P. (Peter), Voutilainen, S. (Sari), Vrijheid, M. (Martine), Wagner, A. (Aline), Wagner, A. (Anne), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. X. (Ya Xing), Wannamethee, S. G. (S. Goya), Wei, W. (Wenbin), Whincup, P. H. (Peter H.), Wiecek, A. (Andrzej), Willeit, J. (Johann), Willeit, P. (Peter), Wojtyniak, B. (Bogdan), Wong, A. (Andrew), Woodward, M. (Mark), Wu, F. C. (Frederick C.), Wu, S. (Shouling), Xu, H. (Haiquan), Xu, L. (Liang), Yan, W. (Weili), Yang, X. (Xiaoguang), Ye, X. (Xingwang), Yoshihara, A. (Akihiro), Zambon, S. (Sabina), and Zhao, W. (Wenhua)
Subjects: blood lipids, HDL cholesterol, LDL cholesterol, total cholesterol, nutritional and metabolic diseases, lipids (amino acids, peptides, and proteins), multi-country study
Abstract: Background: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. Methods: We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group. Results: Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China. Conclusions: HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol.
Published: 2020

2. Cerebral small vessel disease genomics and its implications across the lifespan

Author: Sargurupremraj, M. (Muralidharan), Suzuki, H. (Hideaki), Jian, X. (Xueqiu), Sarnowski, C., Evans, T.E (Tavia), Bis, J.C. (Joshua), Eiriksdottir, G. (Gudny), Sakaue, S. (Saori), Terzikhan, N. (Natalie), Habes, M. (Mohamad), Zhao, W. (Wei), Armstrong, N.J. (Nicola J.), Hofer, E. (Edith), Yanek, L.R. (Lisa), Hagenaars, S.P. (Saskia P.), Kumar, R.B. (Rajan B.), Akker, E.B. (Erik) van den, McWhirter, R.E. (Rebekah E.), Trompet, S. (Stella), Mishra, A. (Aniket), Saba, Y. (Yasaman), Satizabal, C.L. (Claudia), Beaudet, G. (Gregory), Petit, L. (Laurent), Tsuchida, A. (Ami), Zago, L. (Laure), Schilling, S. (Sabrina), Sigurdsson, S. (Stefan), Gottesman, R.F. (Rebecca), Lewis, C.E. (Cora E.), Aggarwal, N.T. (Neelum T.), Lopez, O.L. (Oscar), Smith, J.A. (Jennifer A), Valdés Hernández, M.C. (Maria C.), van der Grond, J. (Jeroen), Wright, M.J. (Margaret), Knol, M.J. (Maria J.), Dörr, M. (Marcus), Thomson, R. (Russell), Bordes, C. (Constance), Le Grand, Q. (Quentin), Duperron, M.-G. (Marie-Gabrielle), Smith, A.V. (Albert), Knopman, D.S. (David), Schreiner, P.J. (Pamela), Evans, D.A. (Denis A.), Rotter, J.I. (Jerome I.), Beiser, A. (Alexa), Maniega, S.M. (Susana Muñoz), Beekman, M. (Marian), Trollor, J., Stott, D.J. (David. J.), Vernooij, M.W. (Meike), Wittfeld, K. (Katharina), Niessen, W.J. (Wiro), Soumaré, A. (Aicha), Boerwinkle, E.A. (Eric), Sidney, S. (Stephen), Turner, S.T. (Stephen), Davies, G. (Gail), Thalamuthu, A. (Anbupalam), Völker, U. (Uwe), Buchem, M.A. (Mark) van, Bryan, R.N. (R. Nick), Amin, N. (Najaf), Bastin, M.E. (Mark), Ames, D.J. (David), Teumer, A. (Alexander), Amouyel, P. (Philippe), Kwok, J.B. (John B.), Bülow, R. (Robin), Deary, I.J. (Ian), Schofield, P.R. (Peter R.), Brodaty, H. (Henry), Jiang, J. (Jiyang), Tabara, Y. (Yasuharu), Setoh, K. (Kazuya), Miyamoto, S. (Susumu), Yoshida, K. (Kazumichi), Nagata, M. (Manabu), Kamatani, Y. (Yoichiro), Matsuda, F. (Fumihiko), Psaty, B.M. (Bruce), Bennett, D.A. (David), De Jager, P., Mosley, T.H. (Thomas H.), Sachdev, P.S. (Perminder), Schmidt, R. (Reinhold), Warren, H. (Helen), Evangelou, E. (Evangelos), Trégouët, D.-A. (David-Alexandre), Andrade, M. (Mariza) de, Basu, S. (Saonli), Berr, C. (Claudine), Brody, J.A. (Jennifer A.), Chasman, D.I. (Daniel I.), Dartigues, J.-F., Folsom, A.R. (Aaron), Germain, M. (Marine), de Haan, H. (Hugoline), Heit, J.A. (John), Houwing-Duitermaat, J. (Jeanine), Kabrhel, C. (Christopher), Kraft, P. (Peter), Legal, G. (Grégoire), Lindström, S. (Sara), Monajemi, R. (Ramin), Morange, P.-E. (P.), Psaty, B.M. (Bruce M.), Reitsma, P.H. (Pieter H.), Jarvelin, M.-R. (Marjo-Riitta), Rose, L.M. (Lynda M.), Peyvandi, F. (Flora), Saut, N. (Noemie), Slagboom, E. (Eline), Smadja, D. (David), Smith, N.L. (Nicholas L.), Suchon, P. (Pierre), Tang, W. (Weihong), Taylor, K.D. (Kent D.), Tregouet, D.-A. (David-Alexandre), Tzourio, C. (Christophe), Visser, M.C.H. (Marieke) de, Hylckama Vlieg, A. (Astrid) van, Weng, L.-C., Wiggins, K.L. (Kerri L.), Gormley, A.M., Anttila, V. (Verneri), Winsvold, B.S. (Bendik S.), Palta, P. (Priit), Esko, T. (Tõnu), Pers, T.H. (Tune H.), Farh, K.-H. (Kai-How), Cuenca-Leon, E. (Ester), Muona, M. (Mikko), Furlotte, N.A. (Nicholas A.), Kurth, T. (Tobias), Ingason, A. (Andres), McMahon, G. (George), Ligthart, L. (Lannie), Terwindt, G.M. (Gisela M.), Todt, U. (Unda), Freilinger, T.M. (Tobias M.), Ran, C. (Caroline), Gordon, S.G. (Scott G.), Stam, A.H. (Anine), Steinberg, S. (Stacy), Borck, G. (Guntram), Koiranen, M. (Markku), Quaye, L. (Lydia), Adams, H.H.H. (Hieab H. H.), Lehtimäki, T. (Terho), Sarin, A.-P., Wedenoja, J. (Juho), Hinds, D.A. (David A.), Buring, J.E. (Julie), Schürks, M. (Markus), Ridker, P.M. (Paul M.), Gudlaug Hrafnsdottir, M. (Maria), Stefansson, H. (Hreinn), Ring, S.M. (Susan M.), Hottenga, J.J. (Jouke Jan), Penninx, B.W.J.H. (Brenda), Färkkilä, M. (Markus), Artto, V. (Ville), Kaunisto, M.A. (Mari), Vepsäläinen, S. (Salli), Malik, R. (Rainer), Heath, A.C. (Andrew), Madden, P.A.F. (Pamela A. F.), Martin, N.G. (Nicholas), Montgomery, G.W. (Grant), Kurki, M. (Mitja), Kals, M. (Mart), Mägi, R. (Reedik), Pärn, K. (Kalle), Hämäläinen, E. (Eija), Huang, H. (Hailiang), Byrnes, A.E. (Andrea E.), Franke, L. (Lude), Huang, J. (Jie), Stergiakouli, E. (Evie), Lee, P.H. (Phil H.), Sandor, C. (Cynthia), Webber, C. (Caleb), Cader, Z. (Zameel), Müller-Myhsok, B. (B.), Schreiber, S. (Stefan), Meitinger, T. (Thomas), Hagen, K. (Knut), Salomaa, V. (Veikko), Heikkilä, K. (Kauko), Loehrer, E. (Elizabeth), Uitterlinden, A.G. (André), Hofman, A. (Albert), Duijn, C.M. (Cornelia) van, Cherkas, L. (Lynn), Pedersen, L.M. (Linda M.), Stubhaug, A. (Audun), Nielsen, C.S. (Christopher S.), Männikkö, M. (Minna), Mihailov, E. (Evelin), Milani, L. (Lili), Esserlind, A.-L. (Ann-Louise), Francke Christensen, A. (Anne), Folkmann Hansen, T. (Thomas), Werge, T. (Thomas), Kaprio, J. (Jaakko), Aromaa, A. (Arpo), Raitakari, O. (Olli), Ikram, M.A. (M. Arfan), Spector, T.D. (Timothy), Järvelin, M.-R. (Marjo-Riitta), Metspalu, A. (Andres), Kubisch, C. (Christian), Beckmann, J.S. (Jacques), Ferrari, M.D. (Michel), Belin, A.C. (Andrea C.), Wessman, M. (Maija), van den Maagdenberg, A.M.J.M. (Arn M. J. M.), Zwart, J-A. (John-Anker), Boomsma, D.I. (Dorret), Davey Smith, G. (George), Eriksson, N. (Nicholas), Daly, M.J. (Mark), Neale, B.M. (Benjamin), Olesen, J. (Jes), Chasman, D.I. (Daniel), Nyholt, D.R. (Dale), Palotie, A. (Aarno), Ikram, M.A. (Arfan), Wen, W. (Wei), DeCarli, C. (Charles), Srikanth, V. (Velandai), Jukema, J.W. (Jan Wouter), Slagboom, P.E. (Eline), Kardia, S.L.R. (Sharon), Okada, Y. (Yukinori), Mazoyer, B. (Bernard), Wardlaw, J.M. (J.), Nyquist, P. (Paul), Mather, R., Grabe, H.J. (Hans Jörgen), Schmidt, H. (Helena), Van Duijn, C.M. (Cornelia M.), Gudnason, V. (Vilmundur), Longstreth Jr, W.T., Launer, L.J. (Lenore), Lathrop, M. (Mark), Seshadri, S. (Sudha), Adams, H.H.H. (Hieab), Matthews, P.M. (P.), Fornage, M. (Myriam), Debette, S. (Stéphanie), Sargurupremraj, M. (Muralidharan), Suzuki, H. (Hideaki), Jian, X. (Xueqiu), Sarnowski, C., Evans, T.E (Tavia), Bis, J.C. (Joshua), Eiriksdottir, G. (Gudny), Sakaue, S. (Saori), Terzikhan, N. (Natalie), Habes, M. (Mohamad), Zhao, W. (Wei), Armstrong, N.J. (Nicola J.), Hofer, E. (Edith), Yanek, L.R. (Lisa), Hagenaars, S.P. (Saskia P.), Kumar, R.B. (Rajan B.), Akker, E.B. (Erik) van den, McWhirter, R.E. (Rebekah E.), Trompet, S. (Stella), Mishra, A. (Aniket), Saba, Y. (Yasaman), Satizabal, C.L. (Claudia), Beaudet, G. (Gregory), Petit, L. (Laurent), Tsuchida, A. (Ami), Zago, L. (Laure), Schilling, S. (Sabrina), Sigurdsson, S. (Stefan), Gottesman, R.F. (Rebecca), Lewis, C.E. (Cora E.), Aggarwal, N.T. (Neelum T.), Lopez, O.L. (Oscar), Smith, J.A. (Jennifer A), Valdés Hernández, M.C. (Maria C.), van der Grond, J. (Jeroen), Wright, M.J. (Margaret), Knol, M.J. (Maria J.), Dörr, M. (Marcus), Thomson, R. (Russell), Bordes, C. (Constance), Le Grand, Q. (Quentin), Duperron, M.-G. (Marie-Gabrielle), Smith, A.V. (Albert), Knopman, D.S. (David), Schreiner, P.J. (Pamela), Evans, D.A. (Denis A.), Rotter, J.I. (Jerome I.), Beiser, A. (Alexa), Maniega, S.M. (Susana Muñoz), Beekman, M. (Marian), Trollor, J., Stott, D.J. (David. J.), Vernooij, M.W. (Meike), Wittfeld, K. (Katharina), Niessen, W.J. (Wiro), Soumaré, A. (Aicha), Boerwinkle, E.A. (Eric), Sidney, S. (Stephen), Turner, S.T. (Stephen), Davies, G. (Gail), Thalamuthu, A. (Anbupalam), Völker, U. (Uwe), Buchem, M.A. (Mark) van, Bryan, R.N. (R. Nick), Amin, N. (Najaf), Bastin, M.E. (Mark), Ames, D.J. (David), Teumer, A. (Alexander), Amouyel, P. (Philippe), Kwok, J.B. (John B.), Bülow, R. (Robin), Deary, I.J. (Ian), Schofield, P.R. (Peter R.), Brodaty, H. (Henry), Jiang, J. (Jiyang), Tabara, Y. (Yasuharu), Setoh, K. (Kazuya), Miyamoto, S. (Susumu), Yoshida, K. (Kazumichi), Nagata, M. (Manabu), Kamatani, Y. (Yoichiro), Matsuda, F. (Fumihiko), Psaty, B.M. (Bruce), Bennett, D.A. (David), De Jager, P., Mosley, T.H. (Thomas H.), Sachdev, P.S. (Perminder), Schmidt, R. (Reinhold), Warren, H. (Helen), Evangelou, E. (Evangelos), Trégouët, D.-A. (David-Alexandre), Andrade, M. (Mariza) de, Basu, S. (Saonli), Berr, C. (Claudine), Brody, J.A. (Jennifer A.), Chasman, D.I. (Daniel I.), Dartigues, J.-F., Folsom, A.R. (Aaron), Germain, M. (Marine), de Haan, H. (Hugoline), Heit, J.A. (John), Houwing-Duitermaat, J. (Jeanine), Kabrhel, C. (Christopher), Kraft, P. (Peter), Legal, G. (Grégoire), Lindström, S. (Sara), Monajemi, R. (Ramin), Morange, P.-E. (P.), Psaty, B.M. (Bruce M.), Reitsma, P.H. (Pieter H.), Jarvelin, M.-R. (Marjo-Riitta), Rose, L.M. (Lynda M.), Peyvandi, F. (Flora), Saut, N. (Noemie), Slagboom, E. (Eline), Smadja, D. (David), Smith, N.L. (Nicholas L.), Suchon, P. (Pierre), Tang, W. (Weihong), Taylor, K.D. (Kent D.), Tregouet, D.-A. (David-Alexandre), Tzourio, C. (Christophe), Visser, M.C.H. (Marieke) de, Hylckama Vlieg, A. (Astrid) van, Weng, L.-C., Wiggins, K.L. (Kerri L.), Gormley, A.M., Anttila, V. (Verneri), Winsvold, B.S. (Bendik S.), Palta, P. (Priit), Esko, T. (Tõnu), Pers, T.H. (Tune H.), Farh, K.-H. (Kai-How), Cuenca-Leon, E. (Ester), Muona, M. (Mikko), Furlotte, N.A. (Nicholas A.), Kurth, T. (Tobias), Ingason, A. (Andres), McMahon, G. (George), Ligthart, L. (Lannie), Terwindt, G.M. (Gisela M.), Todt, U. (Unda), Freilinger, T.M. (Tobias M.), Ran, C. (Caroline), Gordon, S.G. (Scott G.), Stam, A.H. (Anine), Steinberg, S. (Stacy), Borck, G. (Guntram), Koiranen, M. (Markku), Quaye, L. (Lydia), Adams, H.H.H. (Hieab H. H.), Lehtimäki, T. (Terho), Sarin, A.-P., Wedenoja, J. (Juho), Hinds, D.A. (David A.), Buring, J.E. (Julie), Schürks, M. (Markus), Ridker, P.M. (Paul M.), Gudlaug Hrafnsdottir, M. (Maria), Stefansson, H. (Hreinn), Ring, S.M. (Susan M.), Hottenga, J.J. (Jouke Jan), Penninx, B.W.J.H. (Brenda), Färkkilä, M. (Markus), Artto, V. (Ville), Kaunisto, M.A. (Mari), Vepsäläinen, S. (Salli), Malik, R. (Rainer), Heath, A.C. (Andrew), Madden, P.A.F. (Pamela A. F.), Martin, N.G. (Nicholas), Montgomery, G.W. (Grant), Kurki, M. (Mitja), Kals, M. (Mart), Mägi, R. (Reedik), Pärn, K. (Kalle), Hämäläinen, E. (Eija), Huang, H. (Hailiang), Byrnes, A.E. (Andrea E.), Franke, L. (Lude), Huang, J. (Jie), Stergiakouli, E. (Evie), Lee, P.H. (Phil H.), Sandor, C. (Cynthia), Webber, C. (Caleb), Cader, Z. (Zameel), Müller-Myhsok, B. (B.), Schreiber, S. (Stefan), Meitinger, T. (Thomas), Hagen, K. (Knut), Salomaa, V. (Veikko), Heikkilä, K. (Kauko), Loehrer, E. (Elizabeth), Uitterlinden, A.G. (André), Hofman, A. (Albert), Duijn, C.M. (Cornelia) van, Cherkas, L. (Lynn), Pedersen, L.M. (Linda M.), Stubhaug, A. (Audun), Nielsen, C.S. (Christopher S.), Männikkö, M. (Minna), Mihailov, E. (Evelin), Milani, L. (Lili), Esserlind, A.-L. (Ann-Louise), Francke Christensen, A. (Anne), Folkmann Hansen, T. (Thomas), Werge, T. (Thomas), Kaprio, J. (Jaakko), Aromaa, A. (Arpo), Raitakari, O. (Olli), Ikram, M.A. (M. Arfan), Spector, T.D. (Timothy), Järvelin, M.-R. (Marjo-Riitta), Metspalu, A. (Andres), Kubisch, C. (Christian), Beckmann, J.S. (Jacques), Ferrari, M.D. (Michel), Belin, A.C. (Andrea C.), Wessman, M. (Maija), van den Maagdenberg, A.M.J.M. (Arn M. J. M.), Zwart, J-A. (John-Anker), Boomsma, D.I. (Dorret), Davey Smith, G. (George), Eriksson, N. (Nicholas), Daly, M.J. (Mark), Neale, B.M. (Benjamin), Olesen, J. (Jes), Chasman, D.I. (Daniel), Nyholt, D.R. (Dale), Palotie, A. (Aarno), Ikram, M.A. (Arfan), Wen, W. (Wei), DeCarli, C. (Charles), Srikanth, V. (Velandai), Jukema, J.W. (Jan Wouter), Slagboom, P.E. (Eline), Kardia, S.L.R. (Sharon), Okada, Y. (Yukinori), Mazoyer, B. (Bernard), Wardlaw, J.M. (J.), Nyquist, P. (Paul), Mather, R., Grabe, H.J. (Hans Jörgen), Schmidt, H. (Helena), Van Duijn, C.M. (Cornelia M.), Gudnason, V. (Vilmundur), Longstreth Jr, W.T., Launer, L.J. (Lenore), Lathrop, M. (Mark), Seshadri, S. (Sudha), Adams, H.H.H. (Hieab), Matthews, P.M. (P.), Fornage, M. (Myriam), and Debette, S. (Stéphanie)
Abstract: White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were associated with altered white matter integrity (p = 2.5×10-7) in brain images from 1,738 young healthy adults, providing insight into the lifetime impact of SVD genetic risk. Mendelian randomization suggested causal association of increasing WMH-volume with stroke, Alzheimer-type dementia, and of increasing blood pressure (BP) with larger WMH-volume, notably also in persons without clinical hypertension. Transcriptome-wide colocalization analyses showed association of WMH-volume with expression of 39 genes, of which four encode known drug targets. Finally, we provide insight into BP-independent biological pathways underlying SVD and suggest potential for genetic stratification of high-risk individuals and for genetically-informed prioritization of drug targets for prevention trials.
Published: 2020
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3. Repositioning of the global epicentre of non-optimal cholesterol

Author: Taddei, C. (Cristina), Zhou, B. (Bin), Bixby, H. (Honor), Carrillo-Larco, R.M. (Rodrigo M.), Danaei, G. (Goodarz), Jackson, R.T. (Rod T.), Farzadfar, F. (Farshad), Sophiea, M.K. (Marisa K.), Di Cesare, M. (Mariachiara), Iurilli, M.L.C. (Maria Laura Caminia), Martinez, A.R. (Andrea Rodriguez), Asghari, G. (Golaleh), Dhana, K. (Klodian), Gulayin, P. (Pablo), Kakarmath, S. (Sujay), Santero, M. (Marilina), Voortman, R.G. (Trudy), Riley, L.M. (Leanne M.), Cowan, M.J. (Melanie J.), Savin, S. (Stefan), Bennett, J.E. (James E.), Stevens, G.A. (Gretchen A.), Paciorek, C.J. (Christopher J.), Aekplakorn, W. (Wichai), Cifkova, R. (Renata), Giampaoli, S. (Simona), Kengne, A.P. (Andre Pascal), Khang, Y.-H. (Young-Ho), Kuulasmaa, K. (Kari), Laxmaiah, A. (Avula), Margozzini, P. (Paula), Mathur, P. (Prashant), Nordestgaard, B.G. (Børge), Zhao, D. (Dong), Aadahl, M. (Mette), Abarca-Gómez, L. (Leandra), Rahim, H.A. (Hanan Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R.J. (Robert J.), Agdeppa, I.A. (Imelda A.), Aghazadeh-Attari, J. (Javad), Aguilar-Salinas, C.A. (Carlos A.), Agyemang, C.O. (Charles), Ahluwalia, T.S. (Tarunveer Singh), Ahmad, N.A. (Noor Ani), Ahmadi, A. (Ali), Ahmadi, N. (Naser), Ahmed, S.H. (Soheir H.), Ahrens, W. (W.), Ajlouni, K. (Kamel), Alarouj, M. (Monira), AlBuhairan, F. (Fadia), AlDhukair, S. (Shahla), Ali, M.M. (Mohamed M.), Alkandari, A. (Abdullah), Alkerwi, A. (Ala’a), Aly, E. (Eman), Amarapurkar, D.N. (Deepak N.), Amouyel, P. (Philippe), Andersen, L.B. (Lars Bo), Anderssen, S.A. (Sigmund A.), Anjana, R.M. (Ranjit Mohan), Ansari-Moghaddam, A. (Alireza), Aounallah-Skhiri, H. (Hajer), Araújo, J. (Joana), Ariansen, I. (Inger), Aris, T. (Tahir), Arku, R.E. (Raphael E.), Arlappa, N. (Nimmathota), Aryal, K.K. (Krishna K.), Aspelund, T. (Thor), Assunção, M.C.F. (Maria Cecília F.), Auvinen, J. (Juha), Avdicová, M. (Mária), Azevedo, A. (Ana), Azizi, J. (Joshan), Azmin, M. (Mehrdad), Balakrishna, N. (Nagalla), Bamoshmoosh, M. (Mohamed), Banach, M. (Maciej), Bandosz, P. (Piotr), Banegas, J.R. (José R.), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Barkat, A. (Amina), Bata, I. (Iqbal), Batieha, A.M. (Anwar M.), Batyrbek, A. (Assembekov), Baur, L.A. (Louise A.), Beaglehole, R. (Robert), Belavendra, A. (Antonisamy), Ben Romdhane, H. (Habiba), Benet, M. (Mikhail), Benn, M. (Marianne), Berkinbayev, S. (Salim), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhargava, S.K. (Santosh K.), Bi, Y. (Yufang), Bienek, A. (Asako), Bikbov, M. (Mukharram), Bista, B. (Bihungum), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Bloch, K.V. (Katia V.), Blokstra, A. (Anneke), Bo, S. (Simona), Boehm, B.O. (Bernhard O.), Boggia, J.G. (Jose G.), Boissonnet, C.P. (Carlos P.), Bonaccio, M. (Marialaura), Bongard, V. (Vanina), Borchini, R. (Rossana), Borghs, H. (Herman), Bovet, P. (Pascal), Brajkovich, I. (Imperia), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Bruno, G. (Graziella), Bugge, A. (Anna), Busch, M.A. (Markus A.), de León, A.C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Can, G. (Günay), Cândido, A.P.C. (Ana Paula C.), Capanzana, M.V. (Mario V.), Capuano, E. (Eduardo), Capuano, V. (Vincenzo), Cardoso, V.C. (Viviane C.), Carvalho, J. (Joana), Casanueva, F.F., Censi, L. (Laura), Chadjigeorgiou, C.A. (Charalambos A.), Chamukuttan, S. (Snehalatha), Chaturvedi, N. (Nish), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, S. (Shuohua), Cheng, C.-Y. (Ching-Yu), Cheraghian, B. (Bahman), Chetrit, A. (Angela), Chiou, S.-T. (Shu-Ti), Chirlaque, M.D. (M.), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Claessens, F. (Frank), Clarke, J. (Janine), Clays, E. (Els), Concin, H. (Hans), Confortin, S.C. (Susana C.), Cooper, C. (Charles), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Crujeiras, A.B. (Ana B.), Csilla, S. (Semánová), Cui, L. (Liufu), Cureau, F.V. (Felipe V.), D’Arrigo, G. (Graziella), d’Orsi, E. (Eleonora), Dallongeville, J., Damasceno, A. (Albertino), Dankner, R. (Rachel), Dantoft, T.M. (Thomas M.), Dauchet, L. (Luc), Davletov, K. (Kairat), Backer, G. (Guy) de, Bacquer, D. (Dirk) de, de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), de Oliveira, P.D. (Paula Duarte), De Ridder, D. (David), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A.D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Hélène), Dennison, E.M. (Elaine), Deschamps, V. (Valérie), Dhimal, M. (Meghnath), Di Castelnuovo, A.F. (Augusto F.), Dika, Z. (Zivka), Djalalinia, S. (Shirin), Dobson, A.J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S.P. (Silvana P.), Döring, A. (Angela), Dorobantu, M. (Maria), Dragano, N. (Nico), Drygas, W. (Wojciech), Du, Y. (Yong), Duante, C.A. (Charmaine A.), Duda, R.B. (Rosemary B.), Dzerve, V. (Vilnis), Dziankowska-Zaborszczyk, E. (Elzbieta), Eddie, R. (Ricky), Eftekhar, E. (Ebrahim), Eggertsen, R. (Robert), Eghtesad, S. (Sareh), Eiben, G. (Gabriele), Ekelund, U. (Ulf), El Ati, J. (Jalila), Eldemire-Shearer, D. (Denise), Eliasen, M. (Marie), Elosua, R. (Roberto), Erasmus, R.T. (Rajiv T.), Erbel, R. (Raimund), Erem, C. (Cihangir), Eriksen, L. (Louise), Hagen, K. (Knut), Escobedo-de la Peña, J. (Jorge), Eslami, S. (Saeid), Esmaeili, A. (Ali), Evans, A. (Alun), Faeh, D. (David), Fall, C.H. (Caroline H.), Faramarzi, E. (Elnaz), Farjam, M. (Mojtaba), Fattahi, M.R. (Mohammad Reza), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fouad, H.M. (Heba M.), Francis, D.K. (Damian K.), do Carmo Franco, M. (Maria), Franco, O.H. (Oscar H.), Frontera, G. (Guillermo), Fujita, Y. (Yuki), Fumihiko, M. (Matsuda), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Galvano, F. (Fabio), Gao, J. (Jingli), Garcia-de-la-Hera, M. (Manoli), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gazzinelli, A. (Andrea), Geleijnse, J.M. (Marianne), Ghanbari, A. (Ali), Ghasemi, E. (Erfan), Gheorghe-Fronea, O.-F. (Oana-Florentina), Ghimire, A. (Anup), Gianfagna, F. (Francesco), Gill, T.K. (Tiffany K.), Giovannelli, J. (Jonathan), Gironella, G. (Glen), Giwercman, A. (Aleksander), Goltzman, D. (David), Gonçalves, H. (Helen), Gonzalez-Chica, D.A. (David A.), Gonzalez-Gross, M. (Marcela), González-Rivas, J.P. (Juan P.), González-Villalpando, C. (Clicerio), González-Villalpando, M.E. (María Elena), Gonzalez, A.R. (Angel R.), Gottrand, F., Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dušan), Gregor, R.D. (Ronald D.), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Grosso, G. (Giuseppe), Gruden, G. (Gabriella), Gu, D. (Dongfeng), Guallar-castillón, P. (Pilar), Guan, O.P. (Ong Peng), Gudmundsson, E.F. (Elias F.), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Gunnlaugsdottir, J. (Johanna), Gupta, R. (Rajeev), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Ha, S. (Seongjun), Hadaegh, F. (Farzad), Haghshenas, R. (Rosa), Hakimi, H. (Hamid), Hambleton, I.R. (Ian R.), Hamzeh, B. (Behrooz), Hantunen, S. (Sari), Kumar, R.H. (Rachakulla Hari), Hashemi-Shahri, S.M. (Seyed Mohammad), Hata, J. (Jun), Haugsgjerd, T. (Teresa), Hayes, A.J. (Alison J.), He, J. (Jiang), He, Y. (Yong), Hendriks, M.E. (Marleen), Henriques, A. (Ana), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hill, A.G. (Allan G.), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Homayounfar, R. (Reza), Hopman, W.M. (Wilma M.), Horimoto, A.R.V.R. (Andrea R. V. R.), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Huerta, J.M. (José María), Huhtaniemi, I.T. (I.), Huisman, M. (Martijn), Hunsberger, M.L. (Monica L.), Husseini, A. (Abdullatif), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (Mohsen), Wong, N.I. (Norazizah Ibrahim), Iglesia, I. (Iris), Ikeda, N. (Nayu), Ikram, M.A. (Arfan), Iotova, V. (Violeta), Irazola, V.E. (Vilma E.), Ishida, T. (Takafumi), Islam, M. (Muhammad), al-Safi Ismail, A. (Aziz), Iwasaki, M. (Masanori), Jacobs, J.M. (Jeremy M.), Jaddou, H.Y. (Hashem Y.), Jafar, T.H. (Tazeen), James, K. (Kenneth), Jamrozik, K., Janszky, I. (Imre), Janus, E. (Edward), Jarvelin, M.-R. (Marjo-Riitta), Jasienska, G. (Grazyna), Jelakovic, A. (Ana), Jelakovic, B. (Bojan), Jennings, G. (Garry), Jensen, G.B. (Gorm), Jeong, S.-L. (Seung-lyeal), Jha, A.K. (Anjani Kumar), Jiang, C.Q. (Chao Qiang), Jimenez, R.O. (Ramon O.), JöCkel, K.-H. (Karl-Heinz), Joffres, M. (Michel), Jokelainen, J.J. (Jari J.), Jonas, J.B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Joukar, F. (Farahnaz), Józwiak, J. (Jacek), Juolevi, A. (Anne), Kafatos, A. (Anthony), Kajantie, E. (Eero), Kalter-Leibovici, O. (Ofra), Kamaruddin, N.A. (Nor Azmi), Kamstrup, P.R. (Pia R.), Karki, K.B. (Khem B.), Katz, J. (Joanne), Kauhanen, J. (Jussi), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Kazakbaeva, G. (Gyulli), Keil, M. (Mark), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Keramati, M. (Maryam), Kerimkulova, A. (Alina), Kersting, M. (Mathilde), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khateeb, M. (Mohammad), Kheradmand, M. (Motahareh), Khosravi, A. (Alireza), Kiechl-Kohlendorfer, U. (Ursula), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, H.C. (Hyeon Chang), Kim, J. (Jeongseon), Kim, Y.-Y. (Yeon-Yong), Klumbiene, J. (Jurate), Knoflach, M. (Michael), Ko, S. (Stephanie), Kohler, H.-P. (Hans-Peter), Kohler, I.V. (Iliana V.), Kolle, E. (Elin), Kolsteren, P. (Patrick), König, J. (Jürgen), Korpelainen, R. (Raija), Korrovits, P. (Paul), Kos, J. (Jelena), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Kowlessur, S. (Sudhir), Kratzer, W. (Wolfgang), Kriemler, S. (Susi), Kristensen, P.L. (Peter Lund), Krokstad, S. (Steiner), Kromhout, D. (Daan), Kujala, U.M. (Urho), Kurjata, P. (Pawel), Kyobutungi, C. (Catherine), Laamiri, F.Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Lambrinou, C.-P. (Christina-Paulina), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Latt, T.S. (Tint Swe), Laugsand, L.E. (Lars E.), Lazo-Porras, M. (Maria), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehmann, N. (Nils), Lehtimäki, T. (Terho), Levitt, N.S. (Naomi S.), Li, Y. (Yanping), Lilly, C.L. (Christa L.), Lim, W.-Y. (Wei-Yen), Lima-Costa, M.F. (Maria Fernanda), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Lin, Y.-T. (Yi-Ting), Kao, W.H.L. (Wen), Linneberg, A. (Allan), Lissner, L. (Lauren), Liu, J. (Jing), Loit, H.-M. (Helle-Mai), Lopez-Garcia, E. (Esther), Lopez, T. (Tania), Lotufo, P.A. (Paulo A), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lundqvist, R. (Robert), Lunet, N. (Nuno), Ma, G. (Guansheng), Machado-Coelho, G.L.L. (George L. L.), Machado-Rodrigues, A.M. (Aristides M.), Machi, S. (Suka), Madar, A.A. (Ahmed A.), Maggi, S. (Stefania), Magliano, D.J., Magriplis, E. (Emmanuella), Mahasampath, G. (Gowri), Maire, B. (Bernard), Makdisse, M. (Marcia), Malekzadeh, F. (Fatemeh), Malekzadeh, R. (Reza), Rao, K.M. (Kodavanti Mallikharjuna), Manios, Y., Mann, J.I. (Jim I.), Mansour-Ghanaei, F. (Fariborz), Manzato, E. (Enzo), Marques-Vidal, P. (Pedro), Martorell, R. (Reynaldo), Mascarenhas, L.P. (Luis P.), Mathiesen, E.B. (Ellisiv), Matsha, T.E. (Tandi E.), Mavrogianni, C. (Christina), McFarlane, S.R. (Shelly R.), McGarvey, S.T. (Stephen T.), McLachlan, S. (Stela), McLean, R.M. (Rachael M.), McLean, S.B. (Scott B.), McNulty, B.A. (Breige A.), Mediene-Benchekor, S. (Sounnia), Mehdipour, P. (Parinaz), Mehlig, K. (Kirsten), Mehrparvar, A.H. (Amir Houshang), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A.M.B. (Ana M.B.), Menon, G.R. (Geetha R.), Merat, S. (Shahin), Mereke, A. (Alibek), Meshram, I.I. (Indrapal I.), Metcalf, P. (Patricia), Meyer, H.E. (Haakon E.), Mi, J. (Jie), Michels, N. (Nathalie), Miller, J.C. (Jody C.), Minderico, C.S. (Cláudia S.), Mini, G.K. (G. K.), Miquel, J.F. (Juan Francisco), Miranda, J.J. (J. Jaime), Mirjalili, M.R. (Mohammad Reza), Mirrakhimov, E. (Erkin), Modesti, P.A. (Pietro A.), Moghaddam, S.S. (Sahar Saeedi), Mohajer, B. (Bahram), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadi, Z. (Zahra), Mohammadifard, N. (Noushin), Mohammadpourhodki, R. (Reza), Mohan, V. (Viswanathan), Mohanna, S. (Salim), Yusoff, M.F.M. (Muhammad Fadhli Mohd), Mohebbi, I. (Iraj), Mohebi, F. (Farnam), Moitry, M. (Marie), Møllehave, L.T. (Line T.), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Momenan, A. (Amirabbas), Mondo, C.K. (Charles K.), Monterrubio-Flores, E. (Eric), Moosazadeh, M. (Mahmood), Morejon, A. (Alain), Moreno, L. (Luis), Morgan, K. (Karen), Morin, S.N. (Suzanne N.), Moschonis, G. (George), Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M.E. (Mohammad Esmaeel), Motta, J. (Jorge), Msyamboza, K.P. (Kelias P.), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Mursu, J. (Jaakko), Mustafa, N. (Norlaila), Nabipour, I. (Iraj), Naderimagham, S. (Shohreh), Nagel, G. (Gabriele), Naidu, B.M. (Balkish M.), Najafi, F. (Farid), Nakamura, H. (Harunobu), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, V.B. (Vinay B.), Nauck, M. (Matthias), Neal, W.A. (William A.), Nejatizadeh, A. (Azim), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Nihal, T. (Thomas), Niiranen, T.J. (Teemu J.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Noale, M. (Marianna), Noboa, O.A. (Oscar A.), Noto, D. (Davide), Nsour, M.A. (Mohannad Al), Nuhoğlu, I. (Irfan), O’Neill, T.W. (Terence W.), O’Reilly, D. (Dermot), Ochoa-Avilés, A.M. (Angélica M.), Oh, K. (Kyungwon), Ohtsuka, R. (Ryutaro), Olafsson, Ö. (Örn), Olié, V. (Valérie), Oliveira, I.O. (Isabel O.), Omar, M.A. (Mohd Azahadi), Onat, A. (Altan), Ong, S.K. (Sok King), Ordunez, P. (Pedro), Ornelas, R. (Rui), Ortiz, P.J. (Pedro J.), Osmond, C. (Clive), Ostojic, S.M. (Sergej M.), Ostovar, A. (Afshin), Otero, J.A. (Johanna A.), Owusu-Dabo, E. (Ellis), Paccaud, F.M. (Fred Michel), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palmieri, L. (Luigi), Pan, W.-H. (Wen-Harn), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W.R. (Winsome R.), Patel, N.D. (Nikhil D.), Peer, N. (Nasheeta), Peixoto, S.V. (Sergio Viana), Peltonen, M. (Markku), Pereira, A. (A.), Peters, A. (Annette), Petersmann, A. (Astrid), Petkeviciene, J. (Janina), Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pichardo, R.N. (Rafael N.), Pigeot, I. (Iris), Pilav, A. (Aida), Pilotto, A. (Alberto), Piwonska, A. (Aleksandra), Pizarro, A.N. (Andreia N.), Plans-Rubió, P. (Pedro), Plata, S. (Silvia), Pohlabeln, H. (Hermann), Porta, M. (Miquel), Portegies, M.L.P. (Marileen), Poudyal, A. (Anil), Pourfarzi, F. (Farhad), Poustchi, H. (Hossein), Pradeepa, R. (Rajendra), Price, J.F. (Jacqueline F.), Providencia, R. (Rui), Puder, J.J. (Jardena J.), Puhakka, S.E. (Soile E.), Punab, M. (Margus), Qorbani, M. (Mostafa), Bao, T.Q. (Tran Quoc), Radisauskas, R. (Ricardas), Rahimikazerooni, S. (Salar), Raitakari, O. (Olli), Rao, S.R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramos, E. (Elisabete), Ramos, R. (Rafel), Rampal, L. (Lekhraj), Rampal, S. (Sanjay), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Revilla, L. (Luis), Rezaianzadeh, A. (Abbas), Ribeiro, R. (Robespierre), Richter, A. (Adrian), Rigo, F. (Fernando), Rinke de Wit, T.F. (Tobias), Rodríguez Artalejo, F. (Fernando), del Cristo Rodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Roggenbuck, U. (Ulla), Rojas-Martinez, R. (Rosalba), Romaguera, D. (Dora), Romeo, E.L. (Elisabetta L.), Rosengren, A. (Annika), Roy, J.G.R. (Joel G. R.), Rubinstein, A. (Adolfo), Ruidavets, J.-B. (Jean-Bernard), Ruiz-Betancourt, B.S. (Blanca Sandra), Russo, P. (Paola), Rust, P. (Petra), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Sadjadi, A. (Alireza), Safarpour, A.R. (Ali Reza), Safiri, S. (Saeid), Saidi, O. (Olfa), Saki, N. (Nader), Salanave, B. (Benoit), Salmerón, D. (Diego), Salomaa, V. (Veikko), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Sans, S. (Susana), Santaliestra-Pasías, A.M. (Alba M.), Santos, D.A. (Diana A.), Santos, M.P. (Maria Paula), Santos, R. (Rute), Saramies, J.L. (Jouko L.), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S., Sawada, N. (Norie), Sbaraini, M. (Mariana), Scazufca, M. (Marcia), Schaan, B.D. (Beatriz D.), Schargrodsky, H. (Herman), Scheidt-Nave, C. (C.), Schienkiewitz, A. (Anja), Schipf, S. (Sabine), Schmidt, C.O. (Carsten O.), Schöttker, B. (Ben), Schramm, S. (Sara), Sebert, S. (Sylvain), Sein, A.A. (Aye Aye), Sen, A. (Abhijit), Sepanlou, S.G. (Sadaf G), Servais, J. (Jennifer), Shakeri, R. (Ramin), Shalnova, S.A. (Svetlana A.), Shamah-Levy, T. (Teresa), Sharafkhah, M. (Maryam), Sharma, S.K. (Sanjib K.), Shaw, J.E., Shayanrad, A. (Amaneh), Shi, Z. (Zumin), Shibuya, K. (Kenji), Shimizu-Furusawa, H. (Hana), Shin, D.W. (Dong Wook), Shin, Y. (Youchan), Shirani, M. (Majid), Shiri, R. (Rahman), Shrestha, N. (Namuna), Si-Ramlee, K. (Khairil), Siani, A. (Alfonso), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Silva, D.A.S. (Diego Augusto Santos), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon A.), Sjöström, M. (Michael), Skaaby, T. (Tea), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Snijder, M.B. (Marieke), Söderberg, S. (Stefan), Soemantri, A. (Augustinus), Sofat, R. (Reecha), Solfrizzi, V. (Vincenzo), Somi, M.H. (Mohammad Hossein), Sonestedt, E. (Emily), Sørensen, T.I.A. (Thorkild), Jérome, C.S. (Charles Sossa), Soumaré, A. (Aicha), Sozmen, K. (Kaan), Sparrenberger, K. (Karen), Staessen, J.A. (Jan), Stathopoulou, M.G. (Maria G), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stessman, J. (Jochanan), Stevanović, R. (Ranko), Stieber, J. (Jutta), Stöckl, D. (Doris), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M.W. (Maria Wany), Suárez-Medina, R. (Ramón), Sun, C.-A. (Chien-An), Sundström, J. (Johan), Suriyawongpaisal, P. (Paibul), Sy, R.G. (Rody G.), Sylva, R.C. (René Charles), Szklo, M. (Moyses), Tai, E.S. (Shyong), Tamosiunas, A. (Abdonas), Tan, E.J. (Eng Joo), Tarawneh, M.R. (Mohammed Rasoul), Tarqui-Mamani, C.B. (Carolina B.), Taylor, A. (Anne), Taylor, J. (Julie), Tell, G.S. (Grethe S.), Tello, T. (Tania), Thankappan, K.R. (K. R.), Thijs, L. (Lutgarde), Thuesen, B.H. (Betina H.), Toft, U. (Ulla), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne), Topbas, M. (Murat), Topór-Madry, R. (Roman), Tormo, M.J., Tornaritis, M.J. (Michael J.), Torrent, M. (Maties), Torres-Collado, L. (Laura), Traissac, P. (Pierre), Trinh, O.T.H. (Oanh T. H.), Truthmann, J. (Julia), Tsugane, S. (Shoichiro), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Tybjaerg-Hansen, A. (Anne), Tzourio, C. (Christophe), Ueda, P. (Peter), Ugel, E. (Eunice), Ulmer, H. (Hanno), Unal, B. (Belgin), Uusitalo, H., Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), Dam, R.M. (Rob) van, Schouw, Y.T. (Yvonne) van der, Van Herck, K. (Koen), Van Minh, H. (Hoang), Rossem, L. (Lenie) van, Schoor, N.M. (Natasja) van, Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Varbo, A. (Anette), Varona-Pérez, P. (Patricia), Vasan, S.K. (Senthil K.), Vatten, L. (Lars), Vega, T. (Tomas), Veidebaum, T. (Toomas), Velasquez-Melendez, G. (Gustavo), Venero-Fernández, S.J. (Silvia J.), Veronesi, G. (Giovanni), Verschuren, W.M.M. (W. M. Monique), Victora, C.G. (Cesar G.), Vidiawati, D. (Dhanasari), Viet, L. (Lucie), Villalpando, S. (Salvador), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vlasoff, T. (Tiina), Vollenweider, P. (Peter), Voutilainen, A. (Ari), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Bebakar, W.M.W. (Wan Mohamad Wan), Mohamud, W.N.W. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, N. (Ningli), Wang, Q. (Qian), Wang, Y.X. (Ya Xing), Wang, Y.-W. (Ying-Wei), Wannamethee, S.G. (Goya), Wedderkopp, N. (Niels), Wei, W. (Wenbin), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Widyahening, I.S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A.H. (Alet), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Willeit, P. (Peter), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong-McClure, R.A. (Roy A.), Wong, A. (Andrew), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C. (Frederick C.), Wu, S. (Shouling), Xu, H. (Haiquan), Xu, L. (Liang), Yan, W. (Weili), Yang, X. (Xiaoguang), Yasuharu, T. (Tabara), Ye, X. (Xingwang), Yeow, T.P. (Toh Peng), Yiallouros, P.K. (P.), Yoosefi, M. (Moein), Yoshihara, A. (Akihiro), You, S.-L. (San-Lin), Younger-Coleman, N.O. (Novie O.), Yusoff, A.F. (Ahmad Faudzi), Zainuddin, A.A. (Ahmad A.), Zakavi, S.R. (Seyed Rasoul), Zali, M.R. (Mohammad Reza), Zamani, F. (Farhad), Zambon, S. (Sabina), Zampelas, A. (Antonis), Zaw, K.K. (Ko Ko), Zdrojewski, T. (T.), Vrkic, T.Z. (Tajana Zeljkovic), Zhang, Z.-Y. (Zhen-Yu), Zhao, W. (Wenhua), Zhen, S. (Shiqi), Zheng, Y. (Yingfeng), Zholdin, B. (Bekbolat), Zhussupov, B. (Baurzhan), Zoghlami, N. (Nada), Cisneros, J.Z. (Julio Zuñiga), Gregg, E.W. (Edward W.), Ezzati, M. (Majid), Taddei, C. (Cristina), Zhou, B. (Bin), Bixby, H. (Honor), Carrillo-Larco, R.M. (Rodrigo M.), Danaei, G. (Goodarz), Jackson, R.T. (Rod T.), Farzadfar, F. (Farshad), Sophiea, M.K. (Marisa K.), Di Cesare, M. (Mariachiara), Iurilli, M.L.C. (Maria Laura Caminia), Martinez, A.R. (Andrea Rodriguez), Asghari, G. (Golaleh), Dhana, K. (Klodian), Gulayin, P. (Pablo), Kakarmath, S. (Sujay), Santero, M. (Marilina), Voortman, R.G. (Trudy), Riley, L.M. (Leanne M.), Cowan, M.J. (Melanie J.), Savin, S. (Stefan), Bennett, J.E. (James E.), Stevens, G.A. (Gretchen A.), Paciorek, C.J. (Christopher J.), Aekplakorn, W. (Wichai), Cifkova, R. (Renata), Giampaoli, S. (Simona), Kengne, A.P. (Andre Pascal), Khang, Y.-H. (Young-Ho), Kuulasmaa, K. (Kari), Laxmaiah, A. (Avula), Margozzini, P. (Paula), Mathur, P. (Prashant), Nordestgaard, B.G. (Børge), Zhao, D. (Dong), Aadahl, M. (Mette), Abarca-Gómez, L. (Leandra), Rahim, H.A. (Hanan Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R.J. (Robert J.), Agdeppa, I.A. (Imelda A.), Aghazadeh-Attari, J. (Javad), Aguilar-Salinas, C.A. (Carlos A.), Agyemang, C.O. (Charles), Ahluwalia, T.S. (Tarunveer Singh), Ahmad, N.A. (Noor Ani), Ahmadi, A. (Ali), Ahmadi, N. (Naser), Ahmed, S.H. (Soheir H.), Ahrens, W. (W.), Ajlouni, K. (Kamel), Alarouj, M. (Monira), AlBuhairan, F. (Fadia), AlDhukair, S. (Shahla), Ali, M.M. (Mohamed M.), Alkandari, A. (Abdullah), Alkerwi, A. (Ala’a), Aly, E. (Eman), Amarapurkar, D.N. (Deepak N.), Amouyel, P. (Philippe), Andersen, L.B. (Lars Bo), Anderssen, S.A. (Sigmund A.), Anjana, R.M. (Ranjit Mohan), Ansari-Moghaddam, A. (Alireza), Aounallah-Skhiri, H. (Hajer), Araújo, J. (Joana), Ariansen, I. (Inger), Aris, T. (Tahir), Arku, R.E. (Raphael E.), Arlappa, N. (Nimmathota), Aryal, K.K. (Krishna K.), Aspelund, T. (Thor), Assunção, M.C.F. (Maria Cecília F.), Auvinen, J. (Juha), Avdicová, M. (Mária), Azevedo, A. (Ana), Azizi, J. (Joshan), Azmin, M. (Mehrdad), Balakrishna, N. (Nagalla), Bamoshmoosh, M. (Mohamed), Banach, M. (Maciej), Bandosz, P. (Piotr), Banegas, J.R. (José R.), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Barkat, A. (Amina), Bata, I. (Iqbal), Batieha, A.M. (Anwar M.), Batyrbek, A. (Assembekov), Baur, L.A. (Louise A.), Beaglehole, R. (Robert), Belavendra, A. (Antonisamy), Ben Romdhane, H. (Habiba), Benet, M. (Mikhail), Benn, M. (Marianne), Berkinbayev, S. (Salim), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhargava, S.K. (Santosh K.), Bi, Y. (Yufang), Bienek, A. (Asako), Bikbov, M. (Mukharram), Bista, B. (Bihungum), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Bloch, K.V. (Katia V.), Blokstra, A. (Anneke), Bo, S. (Simona), Boehm, B.O. (Bernhard O.), Boggia, J.G. (Jose G.), Boissonnet, C.P. (Carlos P.), Bonaccio, M. (Marialaura), Bongard, V. (Vanina), Borchini, R. (Rossana), Borghs, H. (Herman), Bovet, P. (Pascal), Brajkovich, I. (Imperia), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Bruno, G. (Graziella), Bugge, A. (Anna), Busch, M.A. (Markus A.), de León, A.C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Can, G. (Günay), Cândido, A.P.C. (Ana Paula C.), Capanzana, M.V. (Mario V.), Capuano, E. (Eduardo), Capuano, V. (Vincenzo), Cardoso, V.C. (Viviane C.), Carvalho, J. (Joana), Casanueva, F.F., Censi, L. (Laura), Chadjigeorgiou, C.A. (Charalambos A.), Chamukuttan, S. (Snehalatha), Chaturvedi, N. (Nish), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, S. (Shuohua), Cheng, C.-Y. (Ching-Yu), Cheraghian, B. (Bahman), Chetrit, A. (Angela), Chiou, S.-T. (Shu-Ti), Chirlaque, M.D. (M.), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Claessens, F. (Frank), Clarke, J. (Janine), Clays, E. (Els), Concin, H. (Hans), Confortin, S.C. (Susana C.), Cooper, C. (Charles), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Crujeiras, A.B. (Ana B.), Csilla, S. (Semánová), Cui, L. (Liufu), Cureau, F.V. (Felipe V.), D’Arrigo, G. (Graziella), d’Orsi, E. (Eleonora), Dallongeville, J., Damasceno, A. (Albertino), Dankner, R. (Rachel), Dantoft, T.M. (Thomas M.), Dauchet, L. (Luc), Davletov, K. (Kairat), Backer, G. (Guy) de, Bacquer, D. (Dirk) de, de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), de Oliveira, P.D. (Paula Duarte), De Ridder, D. (David), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A.D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Hélène), Dennison, E.M. (Elaine), Deschamps, V. (Valérie), Dhimal, M. (Meghnath), Di Castelnuovo, A.F. (Augusto F.), Dika, Z. (Zivka), Djalalinia, S. (Shirin), Dobson, A.J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S.P. (Silvana P.), Döring, A. (Angela), Dorobantu, M. (Maria), Dragano, N. (Nico), Drygas, W. (Wojciech), Du, Y. (Yong), Duante, C.A. (Charmaine A.), Duda, R.B. (Rosemary B.), Dzerve, V. (Vilnis), Dziankowska-Zaborszczyk, E. (Elzbieta), Eddie, R. (Ricky), Eftekhar, E. (Ebrahim), Eggertsen, R. (Robert), Eghtesad, S. (Sareh), Eiben, G. (Gabriele), Ekelund, U. (Ulf), El Ati, J. (Jalila), Eldemire-Shearer, D. (Denise), Eliasen, M. (Marie), Elosua, R. (Roberto), Erasmus, R.T. (Rajiv T.), Erbel, R. (Raimund), Erem, C. (Cihangir), Eriksen, L. (Louise), Hagen, K. (Knut), Escobedo-de la Peña, J. (Jorge), Eslami, S. (Saeid), Esmaeili, A. (Ali), Evans, A. (Alun), Faeh, D. (David), Fall, C.H. (Caroline H.), Faramarzi, E. (Elnaz), Farjam, M. (Mojtaba), Fattahi, M.R. (Mohammad Reza), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fouad, H.M. (Heba M.), Francis, D.K. (Damian K.), do Carmo Franco, M. (Maria), Franco, O.H. (Oscar H.), Frontera, G. (Guillermo), Fujita, Y. (Yuki), Fumihiko, M. (Matsuda), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Galvano, F. (Fabio), Gao, J. (Jingli), Garcia-de-la-Hera, M. (Manoli), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gazzinelli, A. (Andrea), Geleijnse, J.M. (Marianne), Ghanbari, A. (Ali), Ghasemi, E. (Erfan), Gheorghe-Fronea, O.-F. (Oana-Florentina), Ghimire, A. (Anup), Gianfagna, F. (Francesco), Gill, T.K. (Tiffany K.), Giovannelli, J. (Jonathan), Gironella, G. (Glen), Giwercman, A. (Aleksander), Goltzman, D. (David), Gonçalves, H. (Helen), Gonzalez-Chica, D.A. (David A.), Gonzalez-Gross, M. (Marcela), González-Rivas, J.P. (Juan P.), González-Villalpando, C. (Clicerio), González-Villalpando, M.E. (María Elena), Gonzalez, A.R. (Angel R.), Gottrand, F., Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dušan), Gregor, R.D. (Ronald D.), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Grosso, G. (Giuseppe), Gruden, G. (Gabriella), Gu, D. (Dongfeng), Guallar-castillón, P. (Pilar), Guan, O.P. (Ong Peng), Gudmundsson, E.F. (Elias F.), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Gunnlaugsdottir, J. (Johanna), Gupta, R. (Rajeev), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Ha, S. (Seongjun), Hadaegh, F. (Farzad), Haghshenas, R. (Rosa), Hakimi, H. (Hamid), Hambleton, I.R. (Ian R.), Hamzeh, B. (Behrooz), Hantunen, S. (Sari), Kumar, R.H. (Rachakulla Hari), Hashemi-Shahri, S.M. (Seyed Mohammad), Hata, J. (Jun), Haugsgjerd, T. (Teresa), Hayes, A.J. (Alison J.), He, J. (Jiang), He, Y. (Yong), Hendriks, M.E. (Marleen), Henriques, A. (Ana), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hill, A.G. (Allan G.), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Homayounfar, R. (Reza), Hopman, W.M. (Wilma M.), Horimoto, A.R.V.R. (Andrea R. V. R.), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Huerta, J.M. (José María), Huhtaniemi, I.T. (I.), Huisman, M. (Martijn), Hunsberger, M.L. (Monica L.), Husseini, A. (Abdullatif), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (Mohsen), Wong, N.I. (Norazizah Ibrahim), Iglesia, I. (Iris), Ikeda, N. (Nayu), Ikram, M.A. (Arfan), Iotova, V. (Violeta), Irazola, V.E. (Vilma E.), Ishida, T. (Takafumi), Islam, M. (Muhammad), al-Safi Ismail, A. (Aziz), Iwasaki, M. (Masanori), Jacobs, J.M. (Jeremy M.), Jaddou, H.Y. (Hashem Y.), Jafar, T.H. (Tazeen), James, K. (Kenneth), Jamrozik, K., Janszky, I. (Imre), Janus, E. (Edward), Jarvelin, M.-R. (Marjo-Riitta), Jasienska, G. (Grazyna), Jelakovic, A. (Ana), Jelakovic, B. (Bojan), Jennings, G. (Garry), Jensen, G.B. (Gorm), Jeong, S.-L. (Seung-lyeal), Jha, A.K. (Anjani Kumar), Jiang, C.Q. (Chao Qiang), Jimenez, R.O. (Ramon O.), JöCkel, K.-H. (Karl-Heinz), Joffres, M. (Michel), Jokelainen, J.J. (Jari J.), Jonas, J.B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Joukar, F. (Farahnaz), Józwiak, J. (Jacek), Juolevi, A. (Anne), Kafatos, A. (Anthony), Kajantie, E. (Eero), Kalter-Leibovici, O. (Ofra), Kamaruddin, N.A. (Nor Azmi), Kamstrup, P.R. (Pia R.), Karki, K.B. (Khem B.), Katz, J. (Joanne), Kauhanen, J. (Jussi), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Kazakbaeva, G. (Gyulli), Keil, M. (Mark), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Keramati, M. (Maryam), Kerimkulova, A. (Alina), Kersting, M. (Mathilde), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khateeb, M. (Mohammad), Kheradmand, M. (Motahareh), Khosravi, A. (Alireza), Kiechl-Kohlendorfer, U. (Ursula), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, H.C. (Hyeon Chang), Kim, J. (Jeongseon), Kim, Y.-Y. (Yeon-Yong), Klumbiene, J. (Jurate), Knoflach, M. (Michael), Ko, S. (Stephanie), Kohler, H.-P. (Hans-Peter), Kohler, I.V. (Iliana V.), Kolle, E. (Elin), Kolsteren, P. (Patrick), König, J. (Jürgen), Korpelainen, R. (Raija), Korrovits, P. (Paul), Kos, J. (Jelena), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Kowlessur, S. (Sudhir), Kratzer, W. (Wolfgang), Kriemler, S. (Susi), Kristensen, P.L. (Peter Lund), Krokstad, S. (Steiner), Kromhout, D. (Daan), Kujala, U.M. (Urho), Kurjata, P. (Pawel), Kyobutungi, C. (Catherine), Laamiri, F.Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Lambrinou, C.-P. (Christina-Paulina), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Latt, T.S. (Tint Swe), Laugsand, L.E. (Lars E.), Lazo-Porras, M. (Maria), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehmann, N. (Nils), Lehtimäki, T. (Terho), Levitt, N.S. (Naomi S.), Li, Y. (Yanping), Lilly, C.L. (Christa L.), Lim, W.-Y. (Wei-Yen), Lima-Costa, M.F. (Maria Fernanda), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Lin, Y.-T. (Yi-Ting), Kao, W.H.L. (Wen), Linneberg, A. (Allan), Lissner, L. (Lauren), Liu, J. (Jing), Loit, H.-M. (Helle-Mai), Lopez-Garcia, E. (Esther), Lopez, T. (Tania), Lotufo, P.A. (Paulo A), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lundqvist, R. (Robert), Lunet, N. (Nuno), Ma, G. (Guansheng), Machado-Coelho, G.L.L. (George L. L.), Machado-Rodrigues, A.M. (Aristides M.), Machi, S. (Suka), Madar, A.A. (Ahmed A.), Maggi, S. (Stefania), Magliano, D.J., Magriplis, E. (Emmanuella), Mahasampath, G. (Gowri), Maire, B. (Bernard), Makdisse, M. (Marcia), Malekzadeh, F. (Fatemeh), Malekzadeh, R. (Reza), Rao, K.M. (Kodavanti Mallikharjuna), Manios, Y., Mann, J.I. (Jim I.), Mansour-Ghanaei, F. (Fariborz), Manzato, E. (Enzo), Marques-Vidal, P. (Pedro), Martorell, R. (Reynaldo), Mascarenhas, L.P. (Luis P.), Mathiesen, E.B. (Ellisiv), Matsha, T.E. (Tandi E.), Mavrogianni, C. (Christina), McFarlane, S.R. (Shelly R.), McGarvey, S.T. (Stephen T.), McLachlan, S. (Stela), McLean, R.M. (Rachael M.), McLean, S.B. (Scott B.), McNulty, B.A. (Breige A.), Mediene-Benchekor, S. (Sounnia), Mehdipour, P. (Parinaz), Mehlig, K. (Kirsten), Mehrparvar, A.H. (Amir Houshang), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A.M.B. (Ana M.B.), Menon, G.R. (Geetha R.), Merat, S. (Shahin), Mereke, A. (Alibek), Meshram, I.I. (Indrapal I.), Metcalf, P. (Patricia), Meyer, H.E. (Haakon E.), Mi, J. (Jie), Michels, N. (Nathalie), Miller, J.C. (Jody C.), Minderico, C.S. (Cláudia S.), Mini, G.K. (G. K.), Miquel, J.F. (Juan Francisco), Miranda, J.J. (J. Jaime), Mirjalili, M.R. (Mohammad Reza), Mirrakhimov, E. (Erkin), Modesti, P.A. (Pietro A.), Moghaddam, S.S. (Sahar Saeedi), Mohajer, B. (Bahram), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadi, Z. (Zahra), Mohammadifard, N. (Noushin), Mohammadpourhodki, R. (Reza), Mohan, V. (Viswanathan), Mohanna, S. (Salim), Yusoff, M.F.M. (Muhammad Fadhli Mohd), Mohebbi, I. (Iraj), Mohebi, F. (Farnam), Moitry, M. (Marie), Møllehave, L.T. (Line T.), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Momenan, A. (Amirabbas), Mondo, C.K. (Charles K.), Monterrubio-Flores, E. (Eric), Moosazadeh, M. (Mahmood), Morejon, A. (Alain), Moreno, L. (Luis), Morgan, K. (Karen), Morin, S.N. (Suzanne N.), Moschonis, G. (George), Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M.E. (Mohammad Esmaeel), Motta, J. (Jorge), Msyamboza, K.P. (Kelias P.), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Mursu, J. (Jaakko), Mustafa, N. (Norlaila), Nabipour, I. (Iraj), Naderimagham, S. (Shohreh), Nagel, G. (Gabriele), Naidu, B.M. (Balkish M.), Najafi, F. (Farid), Nakamura, H. (Harunobu), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, V.B. (Vinay B.), Nauck, M. (Matthias), Neal, W.A. (William A.), Nejatizadeh, A. (Azim), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Nihal, T. (Thomas), Niiranen, T.J. (Teemu J.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Noale, M. (Marianna), Noboa, O.A. (Oscar A.), Noto, D. (Davide), Nsour, M.A. (Mohannad Al), Nuhoğlu, I. (Irfan), O’Neill, T.W. (Terence W.), O’Reilly, D. (Dermot), Ochoa-Avilés, A.M. (Angélica M.), Oh, K. (Kyungwon), Ohtsuka, R. (Ryutaro), Olafsson, Ö. (Örn), Olié, V. (Valérie), Oliveira, I.O. (Isabel O.), Omar, M.A. (Mohd Azahadi), Onat, A. (Altan), Ong, S.K. (Sok King), Ordunez, P. (Pedro), Ornelas, R. (Rui), Ortiz, P.J. (Pedro J.), Osmond, C. (Clive), Ostojic, S.M. (Sergej M.), Ostovar, A. (Afshin), Otero, J.A. (Johanna A.), Owusu-Dabo, E. (Ellis), Paccaud, F.M. (Fred Michel), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palmieri, L. (Luigi), Pan, W.-H. (Wen-Harn), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W.R. (Winsome R.), Patel, N.D. (Nikhil D.), Peer, N. (Nasheeta), Peixoto, S.V. (Sergio Viana), Peltonen, M. (Markku), Pereira, A. (A.), Peters, A. (Annette), Petersmann, A. (Astrid), Petkeviciene, J. (Janina), Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pichardo, R.N. (Rafael N.), Pigeot, I. (Iris), Pilav, A. (Aida), Pilotto, A. (Alberto), Piwonska, A. (Aleksandra), Pizarro, A.N. (Andreia N.), Plans-Rubió, P. (Pedro), Plata, S. (Silvia), Pohlabeln, H. (Hermann), Porta, M. (Miquel), Portegies, M.L.P. (Marileen), Poudyal, A. (Anil), Pourfarzi, F. (Farhad), Poustchi, H. (Hossein), Pradeepa, R. (Rajendra), Price, J.F. (Jacqueline F.), Providencia, R. (Rui), Puder, J.J. (Jardena J.), Puhakka, S.E. (Soile E.), Punab, M. (Margus), Qorbani, M. (Mostafa), Bao, T.Q. (Tran Quoc), Radisauskas, R. (Ricardas), Rahimikazerooni, S. (Salar), Raitakari, O. (Olli), Rao, S.R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramos, E. (Elisabete), Ramos, R. (Rafel), Rampal, L. (Lekhraj), Rampal, S. (Sanjay), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Revilla, L. (Luis), Rezaianzadeh, A. (Abbas), Ribeiro, R. (Robespierre), Richter, A. (Adrian), Rigo, F. (Fernando), Rinke de Wit, T.F. (Tobias), Rodríguez Artalejo, F. (Fernando), del Cristo Rodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Roggenbuck, U. (Ulla), Rojas-Martinez, R. (Rosalba), Romaguera, D. (Dora), Romeo, E.L. (Elisabetta L.), Rosengren, A. (Annika), Roy, J.G.R. (Joel G. R.), Rubinstein, A. (Adolfo), Ruidavets, J.-B. (Jean-Bernard), Ruiz-Betancourt, B.S. (Blanca Sandra), Russo, P. (Paola), Rust, P. (Petra), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Sadjadi, A. (Alireza), Safarpour, A.R. (Ali Reza), Safiri, S. (Saeid), Saidi, O. (Olfa), Saki, N. (Nader), Salanave, B. (Benoit), Salmerón, D. (Diego), Salomaa, V. (Veikko), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Sans, S. (Susana), Santaliestra-Pasías, A.M. (Alba M.), Santos, D.A. (Diana A.), Santos, M.P. (Maria Paula), Santos, R. (Rute), Saramies, J.L. (Jouko L.), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S., Sawada, N. (Norie), Sbaraini, M. (Mariana), Scazufca, M. (Marcia), Schaan, B.D. (Beatriz D.), Schargrodsky, H. (Herman), Scheidt-Nave, C. (C.), Schienkiewitz, A. (Anja), Schipf, S. (Sabine), Schmidt, C.O. (Carsten O.), Schöttker, B. (Ben), Schramm, S. (Sara), Sebert, S. (Sylvain), Sein, A.A. (Aye Aye), Sen, A. (Abhijit), Sepanlou, S.G. (Sadaf G), Servais, J. (Jennifer), Shakeri, R. (Ramin), Shalnova, S.A. (Svetlana A.), Shamah-Levy, T. (Teresa), Sharafkhah, M. (Maryam), Sharma, S.K. (Sanjib K.), Shaw, J.E., Shayanrad, A. (Amaneh), Shi, Z. (Zumin), Shibuya, K. (Kenji), Shimizu-Furusawa, H. (Hana), Shin, D.W. (Dong Wook), Shin, Y. (Youchan), Shirani, M. (Majid), Shiri, R. (Rahman), Shrestha, N. (Namuna), Si-Ramlee, K. (Khairil), Siani, A. (Alfonso), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Silva, D.A.S. (Diego Augusto Santos), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon A.), Sjöström, M. (Michael), Skaaby, T. (Tea), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Snijder, M.B. (Marieke), Söderberg, S. (Stefan), Soemantri, A. (Augustinus), Sofat, R. (Reecha), Solfrizzi, V. (Vincenzo), Somi, M.H. (Mohammad Hossein), Sonestedt, E. (Emily), Sørensen, T.I.A. (Thorkild), Jérome, C.S. (Charles Sossa), Soumaré, A. (Aicha), Sozmen, K. (Kaan), Sparrenberger, K. (Karen), Staessen, J.A. (Jan), Stathopoulou, M.G. (Maria G), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stessman, J. (Jochanan), Stevanović, R. (Ranko), Stieber, J. (Jutta), Stöckl, D. (Doris), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M.W. (Maria Wany), Suárez-Medina, R. (Ramón), Sun, C.-A. (Chien-An), Sundström, J. (Johan), Suriyawongpaisal, P. (Paibul), Sy, R.G. (Rody G.), Sylva, R.C. (René Charles), Szklo, M. (Moyses), Tai, E.S. (Shyong), Tamosiunas, A. (Abdonas), Tan, E.J. (Eng Joo), Tarawneh, M.R. (Mohammed Rasoul), Tarqui-Mamani, C.B. (Carolina B.), Taylor, A. (Anne), Taylor, J. (Julie), Tell, G.S. (Grethe S.), Tello, T. (Tania), Thankappan, K.R. (K. R.), Thijs, L. (Lutgarde), Thuesen, B.H. (Betina H.), Toft, U. (Ulla), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne), Topbas, M. (Murat), Topór-Madry, R. (Roman), Tormo, M.J., Tornaritis, M.J. (Michael J.), Torrent, M. (Maties), Torres-Collado, L. (Laura), Traissac, P. (Pierre), Trinh, O.T.H. (Oanh T. H.), Truthmann, J. (Julia), Tsugane, S. (Shoichiro), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Tybjaerg-Hansen, A. (Anne), Tzourio, C. (Christophe), Ueda, P. (Peter), Ugel, E. (Eunice), Ulmer, H. (Hanno), Unal, B. (Belgin), Uusitalo, H., Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), Dam, R.M. (Rob) van, Schouw, Y.T. (Yvonne) van der, Van Herck, K. (Koen), Van Minh, H. (Hoang), Rossem, L. (Lenie) van, Schoor, N.M. (Natasja) van, Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Varbo, A. (Anette), Varona-Pérez, P. (Patricia), Vasan, S.K. (Senthil K.), Vatten, L. (Lars), Vega, T. (Tomas), Veidebaum, T. (Toomas), Velasquez-Melendez, G. (Gustavo), Venero-Fernández, S.J. (Silvia J.), Veronesi, G. (Giovanni), Verschuren, W.M.M. (W. M. Monique), Victora, C.G. (Cesar G.), Vidiawati, D. (Dhanasari), Viet, L. (Lucie), Villalpando, S. (Salvador), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vlasoff, T. (Tiina), Vollenweider, P. (Peter), Voutilainen, A. (Ari), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Bebakar, W.M.W. (Wan Mohamad Wan), Mohamud, W.N.W. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, N. (Ningli), Wang, Q. (Qian), Wang, Y.X. (Ya Xing), Wang, Y.-W. (Ying-Wei), Wannamethee, S.G. (Goya), Wedderkopp, N. (Niels), Wei, W. (Wenbin), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Widyahening, I.S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A.H. (Alet), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Willeit, P. (Peter), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong-McClure, R.A. (Roy A.), Wong, A. (Andrew), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C. (Frederick C.), Wu, S. (Shouling), Xu, H. (Haiquan), Xu, L. (Liang), Yan, W. (Weili), Yang, X. (Xiaoguang), Yasuharu, T. (Tabara), Ye, X. (Xingwang), Yeow, T.P. (Toh Peng), Yiallouros, P.K. (P.), Yoosefi, M. (Moein), Yoshihara, A. (Akihiro), You, S.-L. (San-Lin), Younger-Coleman, N.O. (Novie O.), Yusoff, A.F. (Ahmad Faudzi), Zainuddin, A.A. (Ahmad A.), Zakavi, S.R. (Seyed Rasoul), Zali, M.R. (Mohammad Reza), Zamani, F. (Farhad), Zambon, S. (Sabina), Zampelas, A. (Antonis), Zaw, K.K. (Ko Ko), Zdrojewski, T. (T.), Vrkic, T.Z. (Tajana Zeljkovic), Zhang, Z.-Y. (Zhen-Yu), Zhao, W. (Wenhua), Zhen, S. (Shiqi), Zheng, Y. (Yingfeng), Zholdin, B. (Bekbolat), Zhussupov, B. (Baurzhan), Zoghlami, N. (Nada), Cisneros, J.Z. (Julio Zuñiga), Gregg, E.W. (Edward W.), and Ezzati, M. (Majid)
Abstract: High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiov
Published: 2020
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4. Correction: Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation (Molecular Psychiatry, (2018), 10.1038/s41380-018-0112-7)

Author: Bis, J.C. (Joshua), Jian, X. (Xueqiu), Kunkle, B.W. (Brian W.), Chen, Y. (Yuning), Hamilton-Nelson, K.L. (Kara L.), Bush, W.S. (William S.), Salerno, W.J. (William J.), Lancour, D. (Daniel), Ma, Y. (Yiyi), Renton, A. (Alan), Marcora, E. (Edoardo), Farrell, J.J. (John J.), Zhao, Y. (Yi), Qu, L. (Liming), Ahmad, S. (Shahzad), Amin, N. (Najaf), Amouyel, P. (Philippe), Beecham, G.W., Below, J.E. (Jennifer E.), Campion, D. (Dominique), Cantwell, L.B. (Laura B.), Charbonnier, C. (Camille), Chung, J. (Jaeyoon), Crane, P.K. (Paul K.), Crane, L.M.A., Cupples, L.A. (L. Adrienne), Dartigues, J.-F., Debette, S. (Stéphanie), Deleuze, J.-F. (Jean-François), Fulton, L. (Lucinda), Gabriel, S.B. (Stacey), Genin, E. (Emmanuelle), Gibbs, R.A. (Richard), Goate, A. (Alison), Grenier-Boley, B. (Benjamin), Gupta, N. (Namrata), Haines, J.L. (Jonathan), Havulinna, A.S. (Aki), Helisalmi, S. (Seppo), Hiltunen, M. (Mikko), Howrigan, D.P. (Daniel P.), Ikram, M.A. (Arfan), Kaprio, J. (Jaakko), Konrad, J. (Jan), Kuzma, A. (Amanda), Lander, E.S. (Eric), Lathrop, M. (Mark), Lehtimäki, T. (Terho), Lin, H. (Honghuang), Mattila, K. (Kari), Mayeux, R. (Richard), Muzny, D. (Donna), Nasser, W. (Waleed), Neale, B.M. (Benjamin), Nho, K. (Kwangsik), Nicolas, G. (Gaël), Patel, D. (Devanshi), Kunkle, B. (Brian), Perola, M. (Markus), Psaty, B.M. (Bruce), Quenez, O. (Olivier), Rajabli, F. (Farid), Redon, R. (Richard), Reitz, C. (Christiane), Remes, A. (Anne), Salomaa, V. (Veikko), Sarnowski, C., Schmidt, H. (Helena), Schmidt, M. (Michael), Schmidt, R. (Reinhold), Soininen, H. (H.), Thornton, T.A. (Timothy A.), Tosto, G. (G.), Tzourio, C. (Christophe), Lee, S.J. (Sven) van der, Duijn, C.M. (Cornelia) van, Valladares, O. (Otto), Vardarajan, B.N. (Badri), Wang, L.S. (Li-San), Wang, W. (Weixin), Wijsman, E. (Ellen), Wilson, R.K. (Richard K.), Witten, D. (Daniela), Worley, K.C. (Kim C.), Zhang, X. (Xiaoling), Bellenguez, C. (Céline), Lambert, J.-C. (J.), Kurki, M.I. (Mitja I.), Palotie, A. (Aarno), Daly, M.J. (Mark), Boerwinkle, E.A. (Eric), Lunetta, K.L. (Kathryn), DeStefano, A.L. (Anita), Martin, E.R., Schellenberg, G.D. (Gerard), Seshadri, S. (Sudha), Naj, A.C. (Adam C.), Fornage, M. (Myriam), Farrer, L.A. (Lindsay), Bis, J.C. (Joshua), Jian, X. (Xueqiu), Kunkle, B.W. (Brian W.), Chen, Y. (Yuning), Hamilton-Nelson, K.L. (Kara L.), Bush, W.S. (William S.), Salerno, W.J. (William J.), Lancour, D. (Daniel), Ma, Y. (Yiyi), Renton, A. (Alan), Marcora, E. (Edoardo), Farrell, J.J. (John J.), Zhao, Y. (Yi), Qu, L. (Liming), Ahmad, S. (Shahzad), Amin, N. (Najaf), Amouyel, P. (Philippe), Beecham, G.W., Below, J.E. (Jennifer E.), Campion, D. (Dominique), Cantwell, L.B. (Laura B.), Charbonnier, C. (Camille), Chung, J. (Jaeyoon), Crane, P.K. (Paul K.), Crane, L.M.A., Cupples, L.A. (L. Adrienne), Dartigues, J.-F., Debette, S. (Stéphanie), Deleuze, J.-F. (Jean-François), Fulton, L. (Lucinda), Gabriel, S.B. (Stacey), Genin, E. (Emmanuelle), Gibbs, R.A. (Richard), Goate, A. (Alison), Grenier-Boley, B. (Benjamin), Gupta, N. (Namrata), Haines, J.L. (Jonathan), Havulinna, A.S. (Aki), Helisalmi, S. (Seppo), Hiltunen, M. (Mikko), Howrigan, D.P. (Daniel P.), Ikram, M.A. (Arfan), Kaprio, J. (Jaakko), Konrad, J. (Jan), Kuzma, A. (Amanda), Lander, E.S. (Eric), Lathrop, M. (Mark), Lehtimäki, T. (Terho), Lin, H. (Honghuang), Mattila, K. (Kari), Mayeux, R. (Richard), Muzny, D. (Donna), Nasser, W. (Waleed), Neale, B.M. (Benjamin), Nho, K. (Kwangsik), Nicolas, G. (Gaël), Patel, D. (Devanshi), Kunkle, B. (Brian), Perola, M. (Markus), Psaty, B.M. (Bruce), Quenez, O. (Olivier), Rajabli, F. (Farid), Redon, R. (Richard), Reitz, C. (Christiane), Remes, A. (Anne), Salomaa, V. (Veikko), Sarnowski, C., Schmidt, H. (Helena), Schmidt, M. (Michael), Schmidt, R. (Reinhold), Soininen, H. (H.), Thornton, T.A. (Timothy A.), Tosto, G. (G.), Tzourio, C. (Christophe), Lee, S.J. (Sven) van der, Duijn, C.M. (Cornelia) van, Valladares, O. (Otto), Vardarajan, B.N. (Badri), Wang, L.S. (Li-San), Wang, W. (Weixin), Wijsman, E. (Ellen), Wilson, R.K. (Richard K.), Witten, D. (Daniela), Worley, K.C. (Kim C.), Zhang, X. (Xiaoling), Bellenguez, C. (Céline), Lambert, J.-C. (J.), Kurki, M.I. (Mitja I.), Palotie, A. (Aarno), Daly, M.J. (Mark), Boerwinkle, E.A. (Eric), Lunetta, K.L. (Kathryn), DeStefano, A.L. (Anita), Martin, E.R., Schellenberg, G.D. (Gerard), Seshadri, S. (Sudha), Naj, A.C. (Adam C.), Fornage, M. (Myriam), and Farrer, L.A. (Lindsay)
Abstract: Following publication, the authors noticed that ‘Laura Cantwell’, ‘Otto Valladares’, and ‘Li-San Wang’ were inadvertently omitted from the author list. These authors have now been added to the author list in 21st, 77th, and 79th position, respectively. This has been corrected in both the PDF and HTML versions of the article.
Published: 2019
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5. Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease

Author: Mishra, A. (Aniket), Chauhan, G, Violleau, M.H., Vojinović, D. (Dina), Jian, X.Q., Bis, J.C. (Joshua), Li, S. (Susie), Saba, Y, Grenier-Boley, B. (Benjamin), Yang, Q., Bartz, TM, Hofer, E. (Edith), Soumare, A, Peng, F., Duperron, M.G., Foglio, M., Mosley, T.H. (Thomas), Schmidt, R. (Reinhold), Psaty, B.M. (Bruce), Launer, LJ, Boerwinkle, E.A. (Eric), Zhu, Y. (Yicheng), Mazoyer, B. (Bernard), Lathrop, M. (Mark), Bellenguez, C. (Céline), Duijn, C.M., Ikram, M.A. (Arfan), Schmidt, H, Longstreth Jr, W.T., Fornage, M. (Myriam), Seshadri, S. (Sudha), Joutel, A., Tzourio, C. (Christophe), Debette, S. (Stéphanie), Mishra, A. (Aniket), Chauhan, G, Violleau, M.H., Vojinović, D. (Dina), Jian, X.Q., Bis, J.C. (Joshua), Li, S. (Susie), Saba, Y, Grenier-Boley, B. (Benjamin), Yang, Q., Bartz, TM, Hofer, E. (Edith), Soumare, A, Peng, F., Duperron, M.G., Foglio, M., Mosley, T.H. (Thomas), Schmidt, R. (Reinhold), Psaty, B.M. (Bruce), Launer, LJ, Boerwinkle, E.A. (Eric), Zhu, Y. (Yicheng), Mazoyer, B. (Bernard), Lathrop, M. (Mark), Bellenguez, C. (Céline), Duijn, C.M., Ikram, M.A. (Arfan), Schmidt, H, Longstreth Jr, W.T., Fornage, M. (Myriam), Seshadri, S. (Sudha), Joutel, A., Tzourio, C. (Christophe), and Debette, S. (Stéphanie)
Published: 2019
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6. Erratum to: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Author: Evangelou, E. (Evangelos), Warren, H. (Helen), Mosen-Ansorena, D. (David), Mifsud, B. (Borbala), Pazoki, R. (Raha), Gao, H. (He), Ntritsos, G. (Georgios), Dimou, N. (Niki), Cabrera, C.P. (Claudia P.), Karaman, I. (Ibrahim), Ng, F.L. (Fu Liang), Evangelou, M. (Marina), Witkowska, K. (Katarzyna), Tzanis, E. (Evan), Hellwege, J.N. (Jacklyn N.), Giri, A. (Ayush), Velez Edwards, D.R. (Digna R.), Sun, Y.V. (Yan V.), Cho, K. (Kelly), Gaziano, J.M. (J. Michael), Wilson, P.W.F. (Peter W. F.), Tsao, P.S. (Philip S.), Kovesdy, C.P. (Csaba P.), Esko, T. (Tonu), Mägi, R. (Reedik), Milani, L. (Lili), Almgren, P. (Peter), Boutin, T. (Thibaud), Debette, S. (Stéphanie), Ding, J. (Jun), Giulianini, F. (Franco), Holliday, E.G. (Elizabeth), Jackson, A.U. (Anne), Li-Gao, R. (Ruifang), Lin, W.-Y. (Wei-Yu), Luan, J., Mangino, M. (Massimo), Oldmeadow, C. (Christopher), Prins, B.P. (Bram Peter), Qian, Y. (Yong), Sargurupremraj, M. (Muralidharan), Shah, N. (Nisha), Surendran, P. (Praveen), Thériault, S. (Sébastien), Verweij, N. (Niek), Willems, S.M. (Sara), Zhao, J.-H. (Jing-Hua), Amouyel, P. (Philippe), Connell, J. (John), Mutsert, R. (Reneé) de, Doney, A.S.F. (Alex), Farrall, M. (Martin), Menni, C. (Cristina), Morris, A.D. (Andrew), Noordam, R. (Raymond), Pare, G. (Guillame), Poulter, N.R. (Neil), Shields, D.C. (Denis C.), Stanton, A. (Alice), McG Thom, S.A., Abecasis, G. (Gonçalo), Amin, N. (Najaf), Arking, D.E. (Dan), Ayers, K.L. (Kristin), Barbieri, C.M. (Caterina M.), Batini, C. (Chiara), Bis, J.C. (Joshua), Blake, T. (Tineka), Bochud, M. (Murielle), Boehnke, M. (Michael), Boerwinkle, E. (Eric), Boomsma, D.I. (Dorret I.), Bottinger, E.P. (Erwin P.), Braund, P.S. (Peter), Brumat, M. (Marco), Campbell, A. (Archie), Campbell, H. (Harry), Chakravarti, A. (Aravinda), Chambers, J.C. (John C.), Chauhan, G. (Ganesh), Ciullo, M. (Marina), Cocca, M. (Massimiliano), Collins, F. (Francis), Cordell, H.J. (Heather), Davies, G. (Gail), de Borst, M.H. (Martin H.), Geus, E.J.C. (Eco) de, Deary, I.J. (Ian), Deelen, J. (Joris), Del Greco M, F. (Fabiola), Demirkale, C.Y. (Cumhur Yusuf), Dörr, M. (Marcus), Ehret, G.B. (Georg B.), Elosua, R. (Roberto), Enroth, S. (Stefan), Erzurumluoglu, A.M. (A. Mesut), Ferreira, T. (Teresa), Frånberg, M. (Mattias), Franco, O.H. (Oscar), Gandin, I. (Ilaria), Gasparini, P. (Paolo), Giedraitis, V. (Vilmantas), Gieger, C. (Christian), Girotto, G. (Giorgia), Goel, A. (Anuj), Gow, A.J. (Alan J.), Gudnason, V. (Vilmundur), Guo, X. (Xiuqing), Gyllensten, U. (Ulf), Hamsten, A. (Anders), Harris, T.B. (Tamara), Harris, S.E. (Sarah), Hartman, C.A. (Catharina A.), Havulinna, A.S. (Aki), Hicks, A.A. (Andrew A.), Hofer, E. (Edith), Hofman, A. (Albert), Hottenga, J.J. (Jouke Jan), Huffman, J.E. (Jennifer E.), Hwang, S.-J. (Shih-Jen), Ingelsson, E. (Erik), James, A. (Alan), Jansen, R. (Rick), Jarvelin, M.-R. (Marjo-Riitta), Joehanes, R. (Roby), Johansson, A. (Åsa), Johnson, A.D. (Andrew), Joshi, P.K. (Peter K.), Jousilahti, P. (Pekka), Jukema, J.W. (Jan Wouter), Jula, A. (Antti), Kähönen, M. (Mika), Kathiresan, S. (Sekar), Keavney, B.D. (Bernard D.), Khaw, K.-T. (Kay-Tee), Knekt, P., Knight, J. (Joanne), Kolcic, I. (Ivana), Kooner, J.S. (Jaspal S.), Koskinen, S. (Seppo), Kristiansson, K. (Kati), Kutalik, Z. (Zoltán), Laan, M. (Maris), Larson, M.G. (Martin), Launer, L.J. (Lenore), Lehne, B. (Benjamin), Lehtimäki, T. (Terho), Liewald, D.C.M. (David C. M.), Lin, L. (Li), Kao, W.H.L. (Wen), Lindgren, C.M. (Cecilia M.), Liu, Y. (YongMei), Loos, R.J.F. (Ruth), Lopez, L.M. (Lorna), Lu, Y. (Yingchang), Lyytikäinen, L.-P. (Leo-Pekka), Mahajan, A. (Anubha), Mamasoula, C. (Chrysovalanto), Marrugat, J. (Jaume), Marten, J. (Jonathan), Milaneschi, Y. (Yuri), Morgan, A. (Anna), Morris, A.P. (Andrew), Morrison, A.C. (Alanna), Munson, P.J. (Peter), Nalls, M.A. (Michael), Nandakumar, P. (Priyanka), Nelson, C.P. (Christopher P.), Niiranen, T. (Teemu), Nolte, I.M. (Ilja), Nutile, T. (Teresa), Oldehinkel, A.J. (Albertine), Oostra, B.A. (Ben), O’Reilly, P.F. (Paul F.), Org, E. (Elin), Padmanabhan, S. (Sandosh), Palmas, W. (Walter), Palotie, A. (Aarno), Pattie, A. (Alison), Penninx, B.W.J.H. (Brenda), Perola, M. (Markus), Peters, A. (Annette), Polasek, O. (Ozren), Pramstaller, P.P. (Peter Paul), Nguyen, Q.T. (Quang Tri), Raitakari, O. (Olli), Ren, M. (Meixia), Rettig, R. (Rainer), Rice, K.M. (Kenneth), Ridker, P.M. (Paul), Ried, J.S. (Janina S.), Riese, H. (Harriëtte), Ripatti, S. (Samuli), Robino, A. (Antonietta), Rose, L.M. (Lynda M.), Rotter, J.I. (Jerome I.), Rudan, I. (Igor), Ruggiero, D., Saba, Y. (Yasaman), Sala, C. (Cinzia), Salomaa, V. (Veikko), Samani, N.J. (Nilesh J.), Sarin, A.-P., Schmidt, R. (Reinhold), Schmidt, H. (Helena), Shrine, N.R.G. (Nick), Siscovick, D. (David), Smith, A.V. (Albert), Snieder, H. (Harold), Sõber, S. (Siim), Sorice, R., Starr, J.M. (John), Stott, D.J. (David. J.), Strachan, D.P. (David), Strawbridge, R.J. (Rona), Sundström, J. (Johan), Swertz, M.A. (Morris A.), Taylor, K.D. (Kent), Teumer, A. (Alexander), Tobin, M.D. (Martin), Tomaszewski, M. (Maciej), Toniolo, D. (Daniela), Traglia, M. (Michela), Trompet, S. (Stella), Tuomilehto, J. (Jaakko), Tzourio, C. (Christophe), Uitterlinden, A.G. (André), Vaez, A. (Ahmad), Most, P.J. (Peter) van der, Duijn, C.M. (Cornelia) van, Vergnaud, A.-C. (Anne-Claire), Verwoert, G.C. (Germaine C.), Vitart, V. (Veronique), Völker, U. (Uwe), Vollenweider, P. (Peter), Vuckovic, D. (Dragana), Watkins, H. (Hugh), Wild, S.H. (Sarah), Willemsen, G. (Gonneke), Wilson, J.F. (James F.), Wright, A.F. (Alan), Yao, J. (Jie), Zemunik, T. (Tatijana), Zhang, W. (Weihua), Attia, J. (John), Butterworth, A.S. (Adam S.), Chasman, D.I. (Daniel), Conen, D. (David), Cucca, F. (Francesco), Danesh, J. (John), Hayward, C. (Caroline), Howson, J.M.M. (Joanna M. M.), Laakso, M. (Markku), Lakatta, E.G. (Edward G.), Langenberg, C. (Claudia), Melander, O. (Olle), Mook-Kanamori, D.O. (Dennis O.), Palmer, C.N.A. (Colin N. A.), Risch, L. (Lorenz), Scott, R.A. (Robert), Scott, R.J. (Rodney J.), Sever, P. (Peter), Spector, T.D. (Timothy), van der Harst, P. (Pim), Wareham, N.J. (Nick), Zeggini, E. (Eleftheria), Levy, D. (Daniel), Munroe, P. (Patricia), Newton-Cheh, C. (Christopher), Brown, M.J. (Morris), Metspalu, A. (Andres), Hung, A.M. (Adriana M.), Ódonnell, C.J. (Christopher), Edwards, T.L. (Todd L.), Psaty, B.M. (Bruce), Tzoulaki, I., Barnes, M.J. (Michael), Wain, L.V. (Louise V.), Elliott, P. (Paul), Caulfield, M. (Mark), Evangelou, E. (Evangelos), Warren, H. (Helen), Mosen-Ansorena, D. (David), Mifsud, B. (Borbala), Pazoki, R. (Raha), Gao, H. (He), Ntritsos, G. (Georgios), Dimou, N. (Niki), Cabrera, C.P. (Claudia P.), Karaman, I. (Ibrahim), Ng, F.L. (Fu Liang), Evangelou, M. (Marina), Witkowska, K. (Katarzyna), Tzanis, E. (Evan), Hellwege, J.N. (Jacklyn N.), Giri, A. (Ayush), Velez Edwards, D.R. (Digna R.), Sun, Y.V. (Yan V.), Cho, K. (Kelly), Gaziano, J.M. (J. Michael), Wilson, P.W.F. (Peter W. F.), Tsao, P.S. (Philip S.), Kovesdy, C.P. (Csaba P.), Esko, T. (Tonu), Mägi, R. (Reedik), Milani, L. (Lili), Almgren, P. (Peter), Boutin, T. (Thibaud), Debette, S. (Stéphanie), Ding, J. (Jun), Giulianini, F. (Franco), Holliday, E.G. (Elizabeth), Jackson, A.U. (Anne), Li-Gao, R. (Ruifang), Lin, W.-Y. (Wei-Yu), Luan, J., Mangino, M. (Massimo), Oldmeadow, C. (Christopher), Prins, B.P. (Bram Peter), Qian, Y. (Yong), Sargurupremraj, M. (Muralidharan), Shah, N. (Nisha), Surendran, P. (Praveen), Thériault, S. (Sébastien), Verweij, N. (Niek), Willems, S.M. (Sara), Zhao, J.-H. (Jing-Hua), Amouyel, P. (Philippe), Connell, J. (John), Mutsert, R. (Reneé) de, Doney, A.S.F. (Alex), Farrall, M. (Martin), Menni, C. (Cristina), Morris, A.D. (Andrew), Noordam, R. (Raymond), Pare, G. (Guillame), Poulter, N.R. (Neil), Shields, D.C. (Denis C.), Stanton, A. (Alice), McG Thom, S.A., Abecasis, G. (Gonçalo), Amin, N. (Najaf), Arking, D.E. (Dan), Ayers, K.L. (Kristin), Barbieri, C.M. (Caterina M.), Batini, C. (Chiara), Bis, J.C. (Joshua), Blake, T. (Tineka), Bochud, M. (Murielle), Boehnke, M. (Michael), Boerwinkle, E. (Eric), Boomsma, D.I. (Dorret I.), Bottinger, E.P. (Erwin P.), Braund, P.S. (Peter), Brumat, M. (Marco), Campbell, A. (Archie), Campbell, H. (Harry), Chakravarti, A. (Aravinda), Chambers, J.C. (John C.), Chauhan, G. (Ganesh), Ciullo, M. (Marina), Cocca, M. (Massimiliano), Collins, F. (Francis), Cordell, H.J. (Heather), Davies, G. (Gail), de Borst, M.H. (Martin H.), Geus, E.J.C. (Eco) de, Deary, I.J. (Ian), Deelen, J. (Joris), Del Greco M, F. (Fabiola), Demirkale, C.Y. (Cumhur Yusuf), Dörr, M. (Marcus), Ehret, G.B. (Georg B.), Elosua, R. (Roberto), Enroth, S. (Stefan), Erzurumluoglu, A.M. (A. Mesut), Ferreira, T. (Teresa), Frånberg, M. (Mattias), Franco, O.H. (Oscar), Gandin, I. (Ilaria), Gasparini, P. (Paolo), Giedraitis, V. (Vilmantas), Gieger, C. (Christian), Girotto, G. (Giorgia), Goel, A. (Anuj), Gow, A.J. (Alan J.), Gudnason, V. (Vilmundur), Guo, X. (Xiuqing), Gyllensten, U. (Ulf), Hamsten, A. (Anders), Harris, T.B. (Tamara), Harris, S.E. (Sarah), Hartman, C.A. (Catharina A.), Havulinna, A.S. (Aki), Hicks, A.A. (Andrew A.), Hofer, E. (Edith), Hofman, A. (Albert), Hottenga, J.J. (Jouke Jan), Huffman, J.E. (Jennifer E.), Hwang, S.-J. (Shih-Jen), Ingelsson, E. (Erik), James, A. (Alan), Jansen, R. (Rick), Jarvelin, M.-R. (Marjo-Riitta), Joehanes, R. (Roby), Johansson, A. (Åsa), Johnson, A.D. (Andrew), Joshi, P.K. (Peter K.), Jousilahti, P. (Pekka), Jukema, J.W. (Jan Wouter), Jula, A. (Antti), Kähönen, M. (Mika), Kathiresan, S. (Sekar), Keavney, B.D. (Bernard D.), Khaw, K.-T. (Kay-Tee), Knekt, P., Knight, J. (Joanne), Kolcic, I. (Ivana), Kooner, J.S. (Jaspal S.), Koskinen, S. (Seppo), Kristiansson, K. (Kati), Kutalik, Z. (Zoltán), Laan, M. (Maris), Larson, M.G. (Martin), Launer, L.J. (Lenore), Lehne, B. (Benjamin), Lehtimäki, T. (Terho), Liewald, D.C.M. (David C. M.), Lin, L. (Li), Kao, W.H.L. (Wen), Lindgren, C.M. (Cecilia M.), Liu, Y. (YongMei), Loos, R.J.F. (Ruth), Lopez, L.M. (Lorna), Lu, Y. (Yingchang), Lyytikäinen, L.-P. (Leo-Pekka), Mahajan, A. (Anubha), Mamasoula, C. (Chrysovalanto), Marrugat, J. (Jaume), Marten, J. (Jonathan), Milaneschi, Y. (Yuri), Morgan, A. (Anna), Morris, A.P. (Andrew), Morrison, A.C. (Alanna), Munson, P.J. (Peter), Nalls, M.A. (Michael), Nandakumar, P. (Priyanka), Nelson, C.P. (Christopher P.), Niiranen, T. (Teemu), Nolte, I.M. (Ilja), Nutile, T. (Teresa), Oldehinkel, A.J. (Albertine), Oostra, B.A. (Ben), O’Reilly, P.F. (Paul F.), Org, E. (Elin), Padmanabhan, S. (Sandosh), Palmas, W. (Walter), Palotie, A. (Aarno), Pattie, A. (Alison), Penninx, B.W.J.H. (Brenda), Perola, M. (Markus), Peters, A. (Annette), Polasek, O. (Ozren), Pramstaller, P.P. (Peter Paul), Nguyen, Q.T. (Quang Tri), Raitakari, O. (Olli), Ren, M. (Meixia), Rettig, R. (Rainer), Rice, K.M. (Kenneth), Ridker, P.M. (Paul), Ried, J.S. (Janina S.), Riese, H. (Harriëtte), Ripatti, S. (Samuli), Robino, A. (Antonietta), Rose, L.M. (Lynda M.), Rotter, J.I. (Jerome I.), Rudan, I. (Igor), Ruggiero, D., Saba, Y. (Yasaman), Sala, C. (Cinzia), Salomaa, V. (Veikko), Samani, N.J. (Nilesh J.), Sarin, A.-P., Schmidt, R. (Reinhold), Schmidt, H. (Helena), Shrine, N.R.G. (Nick), Siscovick, D. (David), Smith, A.V. (Albert), Snieder, H. (Harold), Sõber, S. (Siim), Sorice, R., Starr, J.M. (John), Stott, D.J. (David. J.), Strachan, D.P. (David), Strawbridge, R.J. (Rona), Sundström, J. (Johan), Swertz, M.A. (Morris A.), Taylor, K.D. (Kent), Teumer, A. (Alexander), Tobin, M.D. (Martin), Tomaszewski, M. (Maciej), Toniolo, D. (Daniela), Traglia, M. (Michela), Trompet, S. (Stella), Tuomilehto, J. (Jaakko), Tzourio, C. (Christophe), Uitterlinden, A.G. (André), Vaez, A. (Ahmad), Most, P.J. (Peter) van der, Duijn, C.M. (Cornelia) van, Vergnaud, A.-C. (Anne-Claire), Verwoert, G.C. (Germaine C.), Vitart, V. (Veronique), Völker, U. (Uwe), Vollenweider, P. (Peter), Vuckovic, D. (Dragana), Watkins, H. (Hugh), Wild, S.H. (Sarah), Willemsen, G. (Gonneke), Wilson, J.F. (James F.), Wright, A.F. (Alan), Yao, J. (Jie), Zemunik, T. (Tatijana), Zhang, W. (Weihua), Attia, J. (John), Butterworth, A.S. (Adam S.), Chasman, D.I. (Daniel), Conen, D. (David), Cucca, F. (Francesco), Danesh, J. (John), Hayward, C. (Caroline), Howson, J.M.M. (Joanna M. M.), Laakso, M. (Markku), Lakatta, E.G. (Edward G.), Langenberg, C. (Claudia), Melander, O. (Olle), Mook-Kanamori, D.O. (Dennis O.), Palmer, C.N.A. (Colin N. A.), Risch, L. (Lorenz), Scott, R.A. (Robert), Scott, R.J. (Rodney J.), Sever, P. (Peter), Spector, T.D. (Timothy), van der Harst, P. (Pim), Wareham, N.J. (Nick), Zeggini, E. (Eleftheria), Levy, D. (Daniel), Munroe, P. (Patricia), Newton-Cheh, C. (Christopher), Brown, M.J. (Morris), Metspalu, A. (Andres), Hung, A.M. (Adriana M.), Ódonnell, C.J. (Christopher), Edwards, T.L. (Todd L.), Psaty, B.M. (Bruce), Tzoulaki, I., Barnes, M.J. (Michael), Wain, L.V. (Louise V.), Elliott, P. (Paul), and Caulfield, M. (Mark)
Abstract: In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly in the XML. The error has now been corrected in the HTML version of the paper.
Published: 2018
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7. Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease

Author: Peloso, G.M. (Gina M.), Lee, S.J. (Sven) van der, Sims, R. (Rebecca), van der Lee, S.J. (S. J.), Naj, A.C. (A. C.), Bellenguez, C. (Céline), Badarinarayan, N. (Nandini), Jakobsdottir, M. (Margret), Kunkle, B.W. (B. W.), Boland, A. (A.), Raybould, R. (R.), Bis, J.C. (Joshua), Martin, E.R. (E. R.), Grenier-Boley, B. (Benjamin), Heilmann-Heimbach, S. (S.), Chouraki, V. (V.), Kuzma, A.B. (A. B.), Sleegers, K. (K.), Vronskaya, M., Ruiz, A. (A.), Graham, R.R. (Robert), Olaso, R. (Robert), Hoffmann, P. (Per), Grove, M.L. (Megan), Vardarajan, B.N. (Badri), Hiltunen, M. (Mikko), Nöthen, M.M. (Markus), White, C.C. (Charles), Hamilton-Nelson, K.L. (K. L.), Epelbaum, J. (Jacques), Maier, W. (Wolfgang), Choi, S.H. (S. H.), Beecham, G.W., Dulary, C. (C.), Herms, S. (Stefan), Smith, A.V. (Albert), Funk, C.C. (C. C.), Derbois, (), Forstner, A.J. (Andreas), Ahmad, S. (S.), Li, H. (Huaixing), Bacq, D. (D.), Harold, D. (D.), Satizabal, C.L. (Claudia), Valladares, O. (Otto), Squassini, A. (Alessio), Thomas, R. (R.), Brody, J.A. (Jennifer A.), Qu, L. (Liming), Sanchez-Juan, P. (Pascual), Morgan, T. (Thomas), Wolters, F.J. (Frank), Zhao, Y. (Y.), Garcia, F.S. (F. S.), Denning, N. (Nicola), Fornage, M. (Myriam), Malamon, J. (J.), Naranjo, M.C.D. (M. C.D.), Majounie, E. (Elisa), Mosley, T.H. (Thomas H.), Dombroski, B. (B.), Wallon, D. (David), Lupton, M.K. (Michelle), Dupuis, J. (Josée), Whitehead, P. (P.), Fratiglioni, L. (L.), Medway, C. (Christopher), Jian, X. (X.), Mukherjee, S. (S.), Keller, L. (L.), Brown, K. (Kristelle), Lin, H. (Honghuang), Cantwell, L.B. (Laura B.), Panza, F. (F.), McGuinness, B. (B.), Moreno-Grau, S. (S.), Burgess, J.D. (J. D.), Solfrizzi, V. (Vincenzo), Proitsi, P. (P.), Adams, H.H.H. (Hieab), Allen, M. (M.), Seripa, D. (Davide), Pastor, P. (P.), Cupples, L.A. (L. A.), Price, N.D. (N. D.), Hannequin, D. (Didier), Frank-Garcia, A. (Ana), Levy, D. (D.), Chakrabarty, P. (P.), Caffarra, P. (Paolo), Giegling, I. (Ina), Beiser, A. (Alexa), Giedraitis, V. (Vilmantas), Hampel, H. (Heather), Garcia, M.E. (M.), Wang, X. (X.), Lannfelt, L. (Lars), Mecocci, P. (Patrizia), Eiriksdottir, G. (Gudny), Crane, L.M.A., Pasquier, F. (Florence), Boccardi, V. (V.), Henández, I. (I.), Barber, R.C. (R. C.), Scherer, M. (M.), Tárraga, L. (L.), Adams, P.M. (P. M.), Leber, I. (Isabelle), Chen, Y.D.I. (Yii-Der Ida), Albert, M. (Michael), Riedel-Heller, S. (Steffi), Emilsson, V. (Valur), Beekly, D. (D.), Braae, A. (A.), Schmidt, R. (R.), Blacker, D. (D.), Masullo, C., Schmidt, H. (Helena), Doody, R.S. (R. S.), Spalletta, G. (Gianfranco), Longstreth Jr, W.T., Fairchild, T.J. (T. J.), Bossù, P. (P.), Lopez, O.L. (Oscar), Frosch, M.P. (Matthew), Sacchinelli, E. (E.), Ghetti, B. (Bernardino), Yang, Q. (Qiong Fang), Huebinger, R.M. (R. M.), Jessen, F., Li, S. (S.), Kamboh, M.I. (M. I.), Morris, J. (J.), Sotolongo-Grau, O. (O.), Katz, M.J. (M. J.), Corcoran, C. (C.), Dunstan, M.L., Braddel, A. (A.), Thomas, C. (C.), Meggy, A. (A.), Marshall, R. (R.), Gerrish, A. (Amy), Chapman, J. (Jade), Aguilar, M. (M.), Taylor, S. (S.), Hill, M. (M.), Fairén, M.D. (M. D.), Hodges, A. (A.), Vellas, B. (B.), Soininen, H. (H.), Kloszewska, I. (Iwona), Daniilidou, M. (M.), Uphill, J. (James), Patel, Y. (Y.), Hughes, J.T. (J. T.), Lord, J. (J.), Turton, J.C. (James), Hartmann, A.M. (A. M.), Cecchetti, R. (R.), Fenoglio, C. (Chiara), Serpente, M. (Maria), Arcaro, M. (M.), Caltagirone, C. (C.), Orfei, M.D. (M. D.), Ciaramella, A. (A.), Pichler, I. (Irene), Mayhaus, M. (Manuel), Gu, W. (W.), Lleo, A. (Alberto), Fortea, J. (J.), Blesa, R. (Rafael), Barber, I.S. (I. S.), Brookes, K. (K.), Cupidi, C. (Chiara), Maletta, R. (Raffaele), Carrell, D. (D.), Sorbi, S. (Sandro), Moebus, S. (Susanne), Urbano, M. (M.), Pilotto, A. (Alberto), Kornhuber, J. (Johannes), Bosco, P. (Paolo), Todd, S. (S.), Craig, D. (D.), Johnston, J. (J.), Gill, M. (M.), Lawlor, B.A. (B.), Lynch, A. (Aoibhinn), Fox, N.C. (Nick), Hardy, J. (J.), Albin, R.L. (R. L.), Apostolova, L.G. (L. G.), Arnold, S.E. (Steven), Asthana, S. (S.), Atwood, C.S. (Craig), Baldwin, C. (Clinton), Barnes, L.L. (L. L.), Barral, S. (Sandra), Beach, T.G. (Thomas), Becker, J.T. (James), Bigio, E.H. (Eileen), Bird, T.D. (T. D.), Boeve, B.F. (Bradley), Bowen, J.D. (J. D.), Boxer, A.L. (Adam), Burke, J.R. (J. R.), Burns, J.M. (J. M.), Buxbaum, J.D. (J. D.), Cairns, N.J. (N. J.), Cao, C. (C.), Carlson, C. (Chris), Carlsson, C.M. (C. M.), Carney, R.M. (R. M.), Carrasquillo, M.M. (M. M.), Carroll, S.L. (Steven), Diaz, C.C. (C. C.), Chui, H.C. (H. C.), Clark, D.G. (D. G.), Cribbs, D.H. (D. H.), Crocco, E.A. (E. A.), DeCarli, C. (Charles), Dick, M. (M.), Duara, R. (R.), Evans, D.A. (D. A.), Faber, K.M. (Kelley), Fallon, K.B. (K. B.), Fardo, D.W. (D. W.), Farlow, M.R. (M. R.), Ferris, S. (S.), Foroud, T.M. (T. M.), Galasko, D.R. (D. R.), Gearing, M. (Marla), Geschwind, H., Gilbert, J.R. (John R.), Graff-Radford, N.R. (Neill), Green, R.C. (Robert), Growdon, J.H. (J. H.), Hamilton, R.L. (Ronald L.), Harrell, L.E. (L. E.), Honig, L.S. (L. S.), Huentelman, M.J. (M. J.), Hulette, C. (Christine), Hyman, B.T. (Bradley), Jarvik, G.P. (Gail), Abner, E. (E.), Jin, L.W. (L. W.), Jun, G. (G.), Karydas, A. (A.), Kaye, J.A. (Jeffrey), Kim, R. (R.), Kowall, N.W. (N. W.), Kramer, J.H. (Joel), LaFerla, F.M. (F. M.), Lah, J.J. (J. J.), Leverenz, J.B. (J. B.), Levey, A.I. (Allan), Li, G. (Guo), Lieberman, A.P. (A. P.), Lunetta, K.L. (Kathryn), Lyketsos, C.G. (C. G.), Marson, D.C. (D. C.), Martiniuk, F. (F.), Mash, D.C. (Deborah C.), Masliah, E. (Eliezer), McCormick, W.C. (W. C.), McCurry, S.M. (S. M.), McDavid, A.N. (A. N.), McKee, A.C. (A. C.), Mesulam, M. (Marsel), Miller, B.L. (Bruce Lars), Miller, C.A. (C. A.), Miller, J.W. (J. W.), Morris, H. (Huw), Myers, A.J. (Amanda J.), O'Bryant, S. (S.), Olichney, J.M. (J. M.), Pankratz, V.S. (Shane), Parisi, J.E. (Joseph), Paulson, H.L. (Henry), Perry, W. (W.), Peskind, E. (E.), Pierce, A. (A.), Poon, W.W. (W. W.), Potter, H. (H.), Quinn, J.F. (J. F.), Raj, A. (A.), Raskind, M. (M.), Reisberg, B. (B.), Reitz, C. (C.), Ringman, J.M. (J. M.), Roberson, E.D. (E. D.), Rogaeva, E. (Ekaterina), Rosen, H.J. (H. J.), Rosenberg, R.N. (Roger), Sager, M.A. (M. A.), Saykin, A.J. (Andrew), Schneider, J.A. (Julie), Schneider, L.S. (L. S.), Seeley, W.W. (W. W.), Smith, A.G. (A. G.), Sonnen, J.A. (J. A.), Spina, S. (S.), Stern, R.A. (R. A.), Swerdlow, R.H. (R. H.), Tanzi, R.E. (R. E.), Thornton-Wells, T.A. (Tricia), Trojanowski, J.Q. (J. Q.), Troncoso, J.C. (J. C.), Deerlin, V.M. (Vivianna), Van Eldik, L.J. (L. J.), Vinters, H.V. (Harry), Vonsattel, J.P. (Jean Paul), Weintraub, S. (Sandra), Welsh-Bohmer, K.A. (Kathleen), Wilhelmsen, K.C., Williamson, J. (J.), Wingo, T.S. (T. S.), Woltjer, R.L. (Randall), Wright, C.B. (Clinton B.), Yu, C.E. (C. E.), Yu, L. (L.), Garzia, F. (F.), Golamaully, F. (F.), Septier, G. (G.), Engelborghs, S. (Sebastiaan), Vandenberghe, R. (Rik), Deyn, P.P. (Peter) de, Fernadez, C.M. (C. M.), Benito, Y.A. (Y. A.), Thonberg, H. (Håkan), Forsell, C. (C.), Lilius, L. (Lena), Kinhult-Stählbom, A. (A.), Kilander, L. (L.), Brundin, R. (R.), Concari, L. (L.), Helisalmi, S. (S.), Koivisto, A.M. (A. M.), Haapasalo, A. (Annakaisa), Dermecourt, V. (V.), Fievet, N. (N.), Hanon, O. (Olivier), Dufouil, C. (Carole), Brice, A., Ritchie, K. (Karen), Dubois, B. (B.), Himali, J.J. (Jayandra), Keene, C.D. (C. D.), Tschanz, J. (J.), Fitzpatrick, A.L. (Annette), Kukull, W.A., Norton, M. (M.), Aspelund, T. (Thor), Larson, E.B. (Eric B.), Munger, R. (R.), Rotter, J.I. (Jerome I.), Lipton, R.B. (R. B.), Bullido, M.J. (Maria), Hofman, A. (A.), Montine, T.J. (T. J.), Coto, E. (Eliecer), Boerwinkle, E. (E.), Petersen, R.C. (R. C.), Alvarez, V. (V.), Rivadeneira Ramirez, F. (Fernando), Reiman, E.M. (Eric), Gallo, V. (Valentina), O'Donnell, C.J. (Christopher), Reisch, J.S. (J. S.), Bruni, A.C. (Amalia), Royall, D.R. (D. R.), Kubisch, C. (Christian), Sano, M. (M.), Galimberti, D. (Daniela), St. George-Hyslop, P. (Peter), Scarpini, E. (Elio), Tsuang, D.W. (Debby W.), Mancuso, M. (M.), Bonuccelli, U. (Ubaldo), Winslow, A.R. (A. R.), Daniele, A. (A.), Wu, C.K. (C. K.), Peters, O. (Oscar), Nacmias, B. (Benedetta), Riemenschneider, M. (M.), Heun, R. (Reinhard), Brayne, C. (Carol), Rubinsztein, D.C. (David), Bras, J. (J.), Guerreiro, R. (R.), Al-Chalabi, A. (Ammar), Shaw, C.E. (C. E.), Collinge, J. (J.), Mann, D. (D.), Tsolaki, M. (Magda), Clarimón, J. (J.), Sussams, R. (R.), Lovestone, S. (Simon), O'donovan, M.C. (Michael), Owen, M.J. (Michael), Behrens, T.W. (Timothy), Mead, S. (S.), Goate, A.M. (Alison), Uitterlinden, A.G. (A. G.), Holmes, C. (C.), Cruchaga, C. (Carlos), Ingelsson, M. (Martin), Bennett, D.A. (David), Powell, J. (J.), Golde, T.E. (T. E.), Graff, C. (C.), De Jager, P., Morgan, K. (Kevin), Ertekin-Taner, N. (N.), Combarros, O. (Onofre), Psaty, B.M. (Bruce), Passmore, P. (P.), Younkin, S.G. (S. G.), Berr, C. (Claudine), Gudnason, V. (Vilmundur), Rujescu, D. (D.), Dickson, D. (Dennis), Dartigues, J.-F., DeStefano, A.L. (Anita), Ortega-Cubero, S. (S.), Hakonarson, H. (Hakon), Campion, D. (Dominique), Boada, M. (M.), Kauwe, J.K. (J. K.), Farrer, L.A. (Lindsay), Broeckhoven, C. (Christine) van, Ikram, M.A. (Arfan), Jones, L. (L.), Haines, J.L. (Jonathan), Tzourio, C. (Christophe), Launer, L.J. (Lenore), Escott-Price, V. (V.), Mayeux, R. (R.), Deleuze, J.-F. (Jean-François), Amin, N. (Najaf), Holmans, P.A. (Peter A.), Kunkle, B. (Brian), Amouyel, P. (Philippe), Duijn, C.M. (Cornelia) van, Ramirez, A. (Alfredo), Wang, L.S. (L. S.), Lambert, J.-C. (J.), Seshadri, S. (Sudha), Williams, J. (J.), Schellenberg, G.D. (Gerard), Destefano, A.L. (Anita L.), Seshardi, S. (Sudha), Peloso, G.M. (Gina M.), Lee, S.J. (Sven) van der, Sims, R. (Rebecca), van der Lee, S.J. (S. J.), Naj, A.C. (A. C.), Bellenguez, C. (Céline), Badarinarayan, N. (Nandini), Jakobsdottir, M. (Margret), Kunkle, B.W. (B. W.), Boland, A. (A.), Raybould, R. (R.), Bis, J.C. (Joshua), Martin, E.R. (E. R.), Grenier-Boley, B. (Benjamin), Heilmann-Heimbach, S. (S.), Chouraki, V. (V.), Kuzma, A.B. (A. B.), Sleegers, K. (K.), Vronskaya, M., Ruiz, A. (A.), Graham, R.R. (Robert), Olaso, R. (Robert), Hoffmann, P. (Per), Grove, M.L. (Megan), Vardarajan, B.N. (Badri), Hiltunen, M. (Mikko), Nöthen, M.M. (Markus), White, C.C. (Charles), Hamilton-Nelson, K.L. (K. L.), Epelbaum, J. (Jacques), Maier, W. (Wolfgang), Choi, S.H. (S. H.), Beecham, G.W., Dulary, C. (C.), Herms, S. (Stefan), Smith, A.V. (Albert), Funk, C.C. (C. C.), Derbois, (), Forstner, A.J. (Andreas), Ahmad, S. (S.), Li, H. (Huaixing), Bacq, D. (D.), Harold, D. (D.), Satizabal, C.L. (Claudia), Valladares, O. (Otto), Squassini, A. (Alessio), Thomas, R. (R.), Brody, J.A. (Jennifer A.), Qu, L. (Liming), Sanchez-Juan, P. (Pascual), Morgan, T. (Thomas), Wolters, F.J. (Frank), Zhao, Y. (Y.), Garcia, F.S. (F. S.), Denning, N. (Nicola), Fornage, M. (Myriam), Malamon, J. (J.), Naranjo, M.C.D. (M. C.D.), Majounie, E. (Elisa), Mosley, T.H. (Thomas H.), Dombroski, B. (B.), Wallon, D. (David), Lupton, M.K. (Michelle), Dupuis, J. (Josée), Whitehead, P. (P.), Fratiglioni, L. (L.), Medway, C. (Christopher), Jian, X. (X.), Mukherjee, S. (S.), Keller, L. (L.), Brown, K. (Kristelle), Lin, H. (Honghuang), Cantwell, L.B. (Laura B.), Panza, F. (F.), McGuinness, B. (B.), Moreno-Grau, S. (S.), Burgess, J.D. (J. D.), Solfrizzi, V. (Vincenzo), Proitsi, P. (P.), Adams, H.H.H. (Hieab), Allen, M. (M.), Seripa, D. (Davide), Pastor, P. (P.), Cupples, L.A. (L. A.), Price, N.D. (N. D.), Hannequin, D. (Didier), Frank-Garcia, A. (Ana), Levy, D. (D.), Chakrabarty, P. (P.), Caffarra, P. (Paolo), Giegling, I. (Ina), Beiser, A. (Alexa), Giedraitis, V. (Vilmantas), Hampel, H. (Heather), Garcia, M.E. (M.), Wang, X. (X.), Lannfelt, L. (Lars), Mecocci, P. (Patrizia), Eiriksdottir, G. (Gudny), Crane, L.M.A., Pasquier, F. (Florence), Boccardi, V. (V.), Henández, I. (I.), Barber, R.C. (R. C.), Scherer, M. (M.), Tárraga, L. (L.), Adams, P.M. (P. M.), Leber, I. (Isabelle), Chen, Y.D.I. (Yii-Der Ida), Albert, M. (Michael), Riedel-Heller, S. (Steffi), Emilsson, V. (Valur), Beekly, D. (D.), Braae, A. (A.), Schmidt, R. (R.), Blacker, D. (D.), Masullo, C., Schmidt, H. (Helena), Doody, R.S. (R. S.), Spalletta, G. (Gianfranco), Longstreth Jr, W.T., Fairchild, T.J. (T. J.), Bossù, P. (P.), Lopez, O.L. (Oscar), Frosch, M.P. (Matthew), Sacchinelli, E. (E.), Ghetti, B. (Bernardino), Yang, Q. (Qiong Fang), Huebinger, R.M. (R. M.), Jessen, F., Li, S. (S.), Kamboh, M.I. (M. I.), Morris, J. (J.), Sotolongo-Grau, O. (O.), Katz, M.J. (M. J.), Corcoran, C. (C.), Dunstan, M.L., Braddel, A. (A.), Thomas, C. (C.), Meggy, A. (A.), Marshall, R. (R.), Gerrish, A. (Amy), Chapman, J. (Jade), Aguilar, M. (M.), Taylor, S. (S.), Hill, M. (M.), Fairén, M.D. (M. D.), Hodges, A. (A.), Vellas, B. (B.), Soininen, H. (H.), Kloszewska, I. (Iwona), Daniilidou, M. (M.), Uphill, J. (James), Patel, Y. (Y.), Hughes, J.T. (J. T.), Lord, J. (J.), Turton, J.C. (James), Hartmann, A.M. (A. M.), Cecchetti, R. (R.), Fenoglio, C. (Chiara), Serpente, M. (Maria), Arcaro, M. (M.), Caltagirone, C. (C.), Orfei, M.D. (M. D.), Ciaramella, A. (A.), Pichler, I. (Irene), Mayhaus, M. (Manuel), Gu, W. (W.), Lleo, A. (Alberto), Fortea, J. (J.), Blesa, R. (Rafael), Barber, I.S. (I. S.), Brookes, K. (K.), Cupidi, C. (Chiara), Maletta, R. (Raffaele), Carrell, D. (D.), Sorbi, S. (Sandro), Moebus, S. (Susanne), Urbano, M. (M.), Pilotto, A. (Alberto), Kornhuber, J. (Johannes), Bosco, P. (Paolo), Todd, S. (S.), Craig, D. (D.), Johnston, J. (J.), Gill, M. (M.), Lawlor, B.A. (B.), Lynch, A. (Aoibhinn), Fox, N.C. (Nick), Hardy, J. (J.), Albin, R.L. (R. L.), Apostolova, L.G. (L. G.), Arnold, S.E. (Steven), Asthana, S. (S.), Atwood, C.S. (Craig), Baldwin, C. (Clinton), Barnes, L.L. (L. L.), Barral, S. (Sandra), Beach, T.G. (Thomas), Becker, J.T. (James), Bigio, E.H. (Eileen), Bird, T.D. (T. D.), Boeve, B.F. (Bradley), Bowen, J.D. (J. D.), Boxer, A.L. (Adam), Burke, J.R. (J. R.), Burns, J.M. (J. M.), Buxbaum, J.D. (J. D.), Cairns, N.J. (N. J.), Cao, C. (C.), Carlson, C. (Chris), Carlsson, C.M. (C. M.), Carney, R.M. (R. M.), Carrasquillo, M.M. (M. M.), Carroll, S.L. (Steven), Diaz, C.C. (C. C.), Chui, H.C. (H. C.), Clark, D.G. (D. G.), Cribbs, D.H. (D. H.), Crocco, E.A. (E. A.), DeCarli, C. (Charles), Dick, M. (M.), Duara, R. (R.), Evans, D.A. (D. A.), Faber, K.M. (Kelley), Fallon, K.B. (K. B.), Fardo, D.W. (D. W.), Farlow, M.R. (M. R.), Ferris, S. (S.), Foroud, T.M. (T. M.), Galasko, D.R. (D. R.), Gearing, M. (Marla), Geschwind, H., Gilbert, J.R. (John R.), Graff-Radford, N.R. (Neill), Green, R.C. (Robert), Growdon, J.H. (J. H.), Hamilton, R.L. (Ronald L.), Harrell, L.E. (L. E.), Honig, L.S. (L. S.), Huentelman, M.J. (M. J.), Hulette, C. (Christine), Hyman, B.T. (Bradley), Jarvik, G.P. (Gail), Abner, E. (E.), Jin, L.W. (L. W.), Jun, G. (G.), Karydas, A. (A.), Kaye, J.A. (Jeffrey), Kim, R. (R.), Kowall, N.W. (N. W.), Kramer, J.H. (Joel), LaFerla, F.M. (F. M.), Lah, J.J. (J. J.), Leverenz, J.B. (J. B.), Levey, A.I. (Allan), Li, G. (Guo), Lieberman, A.P. (A. P.), Lunetta, K.L. (Kathryn), Lyketsos, C.G. (C. G.), Marson, D.C. (D. C.), Martiniuk, F. (F.), Mash, D.C. (Deborah C.), Masliah, E. (Eliezer), McCormick, W.C. (W. C.), McCurry, S.M. (S. M.), McDavid, A.N. (A. N.), McKee, A.C. (A. C.), Mesulam, M. (Marsel), Miller, B.L. (Bruce Lars), Miller, C.A. (C. A.), Miller, J.W. (J. W.), Morris, H. (Huw), Myers, A.J. (Amanda J.), O'Bryant, S. (S.), Olichney, J.M. (J. M.), Pankratz, V.S. (Shane), Parisi, J.E. (Joseph), Paulson, H.L. (Henry), Perry, W. (W.), Peskind, E. (E.), Pierce, A. (A.), Poon, W.W. (W. W.), Potter, H. (H.), Quinn, J.F. (J. F.), Raj, A. (A.), Raskind, M. (M.), Reisberg, B. (B.), Reitz, C. (C.), Ringman, J.M. (J. M.), Roberson, E.D. (E. D.), Rogaeva, E. (Ekaterina), Rosen, H.J. (H. J.), Rosenberg, R.N. (Roger), Sager, M.A. (M. A.), Saykin, A.J. (Andrew), Schneider, J.A. (Julie), Schneider, L.S. (L. S.), Seeley, W.W. (W. W.), Smith, A.G. (A. G.), Sonnen, J.A. (J. A.), Spina, S. (S.), Stern, R.A. (R. A.), Swerdlow, R.H. (R. H.), Tanzi, R.E. (R. E.), Thornton-Wells, T.A. (Tricia), Trojanowski, J.Q. (J. Q.), Troncoso, J.C. (J. C.), Deerlin, V.M. (Vivianna), Van Eldik, L.J. (L. J.), Vinters, H.V. (Harry), Vonsattel, J.P. (Jean Paul), Weintraub, S. (Sandra), Welsh-Bohmer, K.A. (Kathleen), Wilhelmsen, K.C., Williamson, J. (J.), Wingo, T.S. (T. S.), Woltjer, R.L. (Randall), Wright, C.B. (Clinton B.), Yu, C.E. (C. E.), Yu, L. (L.), Garzia, F. (F.), Golamaully, F. (F.), Septier, G. (G.), Engelborghs, S. (Sebastiaan), Vandenberghe, R. (Rik), Deyn, P.P. (Peter) de, Fernadez, C.M. (C. M.), Benito, Y.A. (Y. A.), Thonberg, H. (Håkan), Forsell, C. (C.), Lilius, L. (Lena), Kinhult-Stählbom, A. (A.), Kilander, L. (L.), Brundin, R. (R.), Concari, L. (L.), Helisalmi, S. (S.), Koivisto, A.M. (A. M.), Haapasalo, A. (Annakaisa), Dermecourt, V. (V.), Fievet, N. (N.), Hanon, O. (Olivier), Dufouil, C. (Carole), Brice, A., Ritchie, K. (Karen), Dubois, B. (B.), Himali, J.J. (Jayandra), Keene, C.D. (C. D.), Tschanz, J. (J.), Fitzpatrick, A.L. (Annette), Kukull, W.A., Norton, M. (M.), Aspelund, T. (Thor), Larson, E.B. (Eric B.), Munger, R. (R.), Rotter, J.I. (Jerome I.), Lipton, R.B. (R. B.), Bullido, M.J. (Maria), Hofman, A. (A.), Montine, T.J. (T. J.), Coto, E. (Eliecer), Boerwinkle, E. (E.), Petersen, R.C. (R. C.), Alvarez, V. (V.), Rivadeneira Ramirez, F. (Fernando), Reiman, E.M. (Eric), Gallo, V. (Valentina), O'Donnell, C.J. (Christopher), Reisch, J.S. (J. S.), Bruni, A.C. (Amalia), Royall, D.R. (D. R.), Kubisch, C. (Christian), Sano, M. (M.), Galimberti, D. (Daniela), St. George-Hyslop, P. (Peter), Scarpini, E. (Elio), Tsuang, D.W. (Debby W.), Mancuso, M. (M.), Bonuccelli, U. (Ubaldo), Winslow, A.R. (A. R.), Daniele, A. (A.), Wu, C.K. (C. K.), Peters, O. (Oscar), Nacmias, B. (Benedetta), Riemenschneider, M. (M.), Heun, R. (Reinhard), Brayne, C. (Carol), Rubinsztein, D.C. (David), Bras, J. (J.), Guerreiro, R. (R.), Al-Chalabi, A. (Ammar), Shaw, C.E. (C. E.), Collinge, J. (J.), Mann, D. (D.), Tsolaki, M. (Magda), Clarimón, J. (J.), Sussams, R. (R.), Lovestone, S. (Simon), O'donovan, M.C. (Michael), Owen, M.J. (Michael), Behrens, T.W. (Timothy), Mead, S. (S.), Goate, A.M. (Alison), Uitterlinden, A.G. (A. G.), Holmes, C. (C.), Cruchaga, C. (Carlos), Ingelsson, M. (Martin), Bennett, D.A. (David), Powell, J. (J.), Golde, T.E. (T. E.), Graff, C. (C.), De Jager, P., Morgan, K. (Kevin), Ertekin-Taner, N. (N.), Combarros, O. (Onofre), Psaty, B.M. (Bruce), Passmore, P. (P.), Younkin, S.G. (S. G.), Berr, C. (Claudine), Gudnason, V. (Vilmundur), Rujescu, D. (D.), Dickson, D. (Dennis), Dartigues, J.-F., DeStefano, A.L. (Anita), Ortega-Cubero, S. (S.), Hakonarson, H. (Hakon), Campion, D. (Dominique), Boada, M. (M.), Kauwe, J.K. (J. K.), Farrer, L.A. (Lindsay), Broeckhoven, C. (Christine) van, Ikram, M.A. (Arfan), Jones, L. (L.), Haines, J.L. (Jonathan), Tzourio, C. (Christophe), Launer, L.J. (Lenore), Escott-Price, V. (V.), Mayeux, R. (R.), Deleuze, J.-F. (Jean-François), Amin, N. (Najaf), Holmans, P.A. (Peter A.), Kunkle, B. (Brian), Amouyel, P. (Philippe), Duijn, C.M. (Cornelia) van, Ramirez, A. (Alfredo), Wang, L.S. (L. S.), Lambert, J.-C. (J.), Seshadri, S. (Sudha), Williams, J. (J.), Schellenberg, G.D. (Gerard), Destefano, A.L. (Anita L.), and Seshardi, S. (Sudha)
Abstract: Introduction: There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (CETP) locus is associated with altered HDL-C. We aimed to assess AD risk by genetically predicted HDL-C. Methods: Ten single nucleotide polymorphisms within the CETP locus predicting HDL-C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. We performed instrumental variables analysis using inverse variance weighting, weighted median, and MR-Egger. Results: Based on 10 single nucleotide polymorphisms distinctly predicting HDL-C in the CETP locus, we found that HDL-C was not associated with risk of AD (P >.7). Discussion: Our study does not support the role of HDL-C on risk of AD through HDL-C altered b
Published: 2018
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8. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

Author: Franceschini, N. (Nora), Giambartolomei, C. (Claudia), Vries, P.S. (Paul) de, Finan, C. (Chris), Bis, J.C. (Joshua), Huntley, R.P. (Rachael P.), Lovering, R.C. (Ruth C.), Tajuddin, S.M. (Salman M.), Winkler, T.W. (Thomas W.), Graff, M. (Misa), Kavousi, M. (Maryam), Dale, C. (Caroline), Smith, A.V. (Albert), Hofer, E. (Edith), Leeuwen, E.M. (Elisa) van, Nolte, I.M. (Ilja), Lu, L. (Lingyi), Scholz, M. (Markus), Sargurupremraj, M. (Muralidharan), Pitkanen, N. (Niina), Franzén, O. (Oscar), Joshi, P.K. (Peter), Noordam, R. (Raymond), Marioni, R.E. (Riccardo), Hwang, S.-J. (Shih-Jen), Musani, S.K. (Solomon K.), Schminke, U. (Ulf), Palmas, W. (Walter), Isaacs, A.J. (Aaron), Correa, D.D., Zonderman, A.B., Hofman, A. (Albert), Teumer, A. (Alexander), Cox, A.J. (Amanda J.), Uitterlinden, A.G. (André), Wong, A. (Andrew), Smit, A.J. (Andries), Newman, A.B. (Anne B.), Britton, A.R., Ruusalepp, A. (Arno), Sennblad, B. (Bengt), Hedblad, B. (Bo), Pasaniuc, B. (Bogdan), Penninx, B.W.J.H. (Brenda), Langefeld, C.D. (Carl D.), Wassel, C.L. (Christina), Tzourio, C. (Christophe), Fava, C. (Cristiano), Baldassarre, D. (Damiano), O’Leary, D.H. (Daniel H.), Teupser, D. (Daniel), Kuh, D. (Diana), Tremoli, E. (Elena), Mannarino, E. (Elmo), Grossi, E. (Enzo), Boerwinkle, E.A. (Eric), Schadt, E.E. (Eric E.), Ingelsson, E. (Erik), Veglia, F. (Fabrizio), Rivadeneira Ramirez, F. (Fernando), Beutner, F. (Frank), Chauhan, G. (Ganesh), Heiss, G. (Gerardo), Snieder, H. (Harold), Campbell, H. (Harry), Völzke, H. (Henry), Markus, H.S. (Hugh), Deary, I.J. (Ian), Jukema, J.W. (Jan Wouter), Graaf, J. (Jacqueline) de, Price, J. (Jacqueline), Pott, J. (Janne), Hopewell, J., Liang, J. (Jingjing), Thiery, J.P. (Joachim), Engmann, J. (Jorgen), Gertow, K. (Karl), Rice, K.M. (Kenneth), Taylor, K.D. (Kent), Dhana, K. (Klodian), Kiemeney, L.A.L.M. (Lambertus A. L. M.), Kao, W.H.L. (Wen), Raffield, L.M. (Laura M.), Launer, L.J. (Lenore), Holdt, L.M. (Lesca), Dörr, M. (Marcus), Kubisch, C. (Christian), Traylor, M. (Matthew), Sitzer, M. (Matthias), Kumari, M. (Meena), Kivimaki, M. (Mika), Nalls, M.A. (Michael), Melander, O. (Olle), Raitakari, O. (Olli), Franco, O.H. (Oscar), Rueda-Ochoa, O.L. (Oscar), Roussos, A. (Alexandra), Whincup, P.H. (Peter), Amouyel, P. (Philippe), Giral, P. (Philippe), Anugu, P. (Pramod), Wong, Q. (Quenna), Malik, R. (Rainer), Rauramaa, R. (Rainer), Burkhardt, R. (Ralph), Hardy, R. (Rebecca), Schmidt, R. (Reinhold), Mutsert, R. (Reneé) de, Strawbridge, R.J. (Rona), Wannamethee, S.G. (Goya), Hägg, S. (Sara), Shah, S. (Sonia), McLachlan, S. (Stela), Trompet, S. (Stella), Seshadri, S. (Sudha), Kurl, S. (Sudhir), Heckbert, S.R. (Susan), Ring, S.M. (Susan), Harris, T.B. (Tamara B.), Lehtimäki, T. (Terho), Galesloot, T.E. (Tessel), Shah, T. (Tina), Faire, U. (Ulf) de, Plagnol, V. (Vincent), Rosamond, W.D. (Wayne), Post, W.S. (Wendy S.), Zhu, X. (Xiaofeng), Zhang, X. (Xiaoling), Guo, X. (Xiuqing), Saba, Y. (Yasaman), Okada, Y. (Yukinori), Mishra, A. (Aniket), Rutten-Jacobs, L. (Loes), Giese, A.-K. (Anne-Katrin), van der Laan, S.W. (Sander W.), Gretarsdottir, S. (Solveig), Anderson, C.D. (Christopher D.), Chong, M. (Michael), Adams, H.H.H. (Hieab), Ago, T. (Tetsuro), Almgren, P. (Peter), Ay, H. (Hakan), Bartz, T.M. (Traci M.), Benavente, O.R. (Oscar R.), Bevan, S. (Steve), Boncoraglio, G. (Giorgio Battista), Brown, R.D. (Robert D.), Butterworth, A.S. (Adam S.), Carrera, C. (Caty), Carty, C.L. (Cara L.), Chasman, D.I. (Daniel), Chen, W-M., Cole, J.W. (John W.), Cotlarciuc, I. (Ioana), Cruchaga, C. (Carlos), Danesh, J. (John), Bakker, P.I.W. (Paul) de, DeStefano, A.L. (Anita), Hoed, M. (Marcel) den, Duan, Q. (Qing), Engelter, S.T. (Stefan), Falcone, G.J. (Guido J.), Gottesman, R.F. (Rebecca), Grewal, R.P. (Raji P.), Gustafsson, S. (Stefan), Haessler, J. (Jeff), Harris, T.B. (Tamara), Hassan, A. (Ahamad), Havulinna, A.S. (Aki), Holliday, E.G. (Elizabeth), Howard, G. (George), Hsu, F.-C. (Fang-Chi), Hyacinth, H.I. (Hyacinth I.), Ikram, M.A. (Arfan), Irvin, M.R. (Marguerite R.), Jian, X. (Xueqiu), Jimenez-Conde, J. (Jordi), Johnson, J.A. (Julie A.), Jukema, J.W. (J. Wouter), Kanai, M. (Masahiro), Keene, K.L. (Keith), Kissela, B.M. (Brett M.), Kleindorfer, D.O. (Dawn O.), Kooperberg, C. (Charles), Kubo, M. (Michiaki), Lange, L.A. (Leslie), Langefeld, C.D. (Carl), Langenberg, C. (Claudia), Lee, J.-M. (Jin-Moo), Lemmens, R. (Robin), Leys, D. (Didier), Lewis, C.M. (Cathryn), Lin, W.-Y. (Wei-Yu), Lindgren, A.G. (Arne G.), Lorentzen, E. (Erik), Magnusson, P.K. (Patrik), Maguire, J.M. (Jane), Manichaikul, A. (Ani), McArdle, P.F. (Patrick), Meschia, J.F. (James F.), Mosley, T.H. (Thomas H.), Ninomiya, T. (Toshiharu), O’Donnell, M.J. (Martin J.), Pulit, S.L. (Sara), Rannikmäe, K. (Kristiina), Reiner, A.P. (Alexander P.), Rexrode, K. (Kathryn), Rich, S.S. (Stephen), Ridker, P.M. (Paul), Rost, N.S. (Natalia), Rothwell, P.M. (Peter), Rundek, T. (Tatjana), Muir, K.W. (Keith), Sakaue, S. (Saori), Sale, M.M. (Michele M.), Salomaa, V. (Veikko), Sapkota, B.R. (Bishwa R.), Schmidt, C.O. (Carsten O.), Sharma, P. (Pankaj), Slowik, A. (Agnieszka), Sudlow, C. (Cathie), Tanislav, C. (Christian), Tatlisumak, T. (Turgut), Thijs, V. (Vincent), Thorleifsson, G. (Gudmar), Thorsteinsdottir, U. (Unnur), Tiedt, S. (Steffen), Walters, M. (Matthew), Wareham, N.J. (Nick), Wassertheil-Smoller, S. (Sylvia), Wiggins, K.L. (Kerri), Yang, Q. (Qiong Fang), Yusuf, S. (Salim), Pastinen, T. (Tomi), Schadt, E.E. (Eric), Koplev, S. (Simon), Codoni, V. (Veronica), Civelek, M. (Mete), Smith, N.L. (Nicholas), Tregouet, D.-A. (David-Alexandre), Christophersen, I.E. (Ingrid E.), Roselli, C. (Carolina), Lubitz, S.A. (Steven A.), Ellinor, P.T. (Patrick), Tai, E.S. (E. Shyong), Kooner, J.S. (Jaspal S.), Kato, N. (Norihiro), He, J. (Jiang), Harst, P. (Pim) van der, Elliott, P. (Paul), Chambers, J.C. (John C.), Takeuchi, F. (Fumihiko), Johnson, A.D. (Andrew), Sanghera, D.K. (Dharambir K.), Jern, C. (Christina), Strbian, D. (Daniel), Fernandez-Cadenas, I. (Israel), Longstreth Jr, W.T., Rolfs, A. (Arndt), Hata, J. (Jun), Woo, D. (Daniel), Rosand, J. (Jonathan), Pare, G. (Guillame), Saleheen, D. (Danish), Zwart, J-A. (John-Anker), Worrall, B.B. (Bradford B.), Kittner, T. (Thomas), Howson, J.M.M. (Joanna M. M.), Kamatani, Y. (Yoichiro), Dehghan, A. (Abbas), Seldenrijk, K.A. (Kees), Morrison, A.C. (Alanna), Hamsten, A. (Anders), Psaty, B.M. (Bruce), Duijn, C.M. (Cornelia) van, Lawlor, D.A. (Debbie), Mook-Kanamori, D.O. (Dennis O.), Bowden, D.W. (Donald), Schmidt, H. (Helena), Wilson, J.F. (James F.), Wilson, J.F. (James), Rotter, J.I. (Jerome I.), Wardlaw, J.M. (J.), Deanfield, J. (John), Halcox, J. (Julian), Lyytikäinen, L.-P. (Leo-Pekka), Loeffler, M. (Markus), Evans, M.K. (Michele), Debette, S. (Stéphanie), Humphries, S.E. (Steve), Völker, U. (Uwe), Gudnason, V. (Vilmundur), Hingorani, A. (Aroon), Björkegren, J.L.M. (Johan L.M.), Casas, J.P. (Juan), Ódonnell, C.J. (Christopher), Morris, R.W. (Richard), Franceschini, N. (Nora), Giambartolomei, C. (Claudia), Vries, P.S. (Paul) de, Finan, C. (Chris), Bis, J.C. (Joshua), Huntley, R.P. (Rachael P.), Lovering, R.C. (Ruth C.), Tajuddin, S.M. (Salman M.), Winkler, T.W. (Thomas W.), Graff, M. (Misa), Kavousi, M. (Maryam), Dale, C. (Caroline), Smith, A.V. (Albert), Hofer, E. (Edith), Leeuwen, E.M. (Elisa) van, Nolte, I.M. (Ilja), Lu, L. (Lingyi), Scholz, M. (Markus), Sargurupremraj, M. (Muralidharan), Pitkanen, N. (Niina), Franzén, O. (Oscar), Joshi, P.K. (Peter), Noordam, R. (Raymond), Marioni, R.E. (Riccardo), Hwang, S.-J. (Shih-Jen), Musani, S.K. (Solomon K.), Schminke, U. (Ulf), Palmas, W. (Walter), Isaacs, A.J. (Aaron), Correa, D.D., Zonderman, A.B., Hofman, A. (Albert), Teumer, A. (Alexander), Cox, A.J. (Amanda J.), Uitterlinden, A.G. (André), Wong, A. (Andrew), Smit, A.J. (Andries), Newman, A.B. (Anne B.), Britton, A.R., Ruusalepp, A. (Arno), Sennblad, B. (Bengt), Hedblad, B. (Bo), Pasaniuc, B. (Bogdan), Penninx, B.W.J.H. (Brenda), Langefeld, C.D. (Carl D.), Wassel, C.L. (Christina), Tzourio, C. (Christophe), Fava, C. (Cristiano), Baldassarre, D. (Damiano), O’Leary, D.H. (Daniel H.), Teupser, D. (Daniel), Kuh, D. (Diana), Tremoli, E. (Elena), Mannarino, E. (Elmo), Grossi, E. (Enzo), Boerwinkle, E.A. (Eric), Schadt, E.E. (Eric E.), Ingelsson, E. (Erik), Veglia, F. (Fabrizio), Rivadeneira Ramirez, F. (Fernando), Beutner, F. (Frank), Chauhan, G. (Ganesh), Heiss, G. (Gerardo), Snieder, H. (Harold), Campbell, H. (Harry), Völzke, H. (Henry), Markus, H.S. (Hugh), Deary, I.J. (Ian), Jukema, J.W. (Jan Wouter), Graaf, J. (Jacqueline) de, Price, J. (Jacqueline), Pott, J. (Janne), Hopewell, J., Liang, J. (Jingjing), Thiery, J.P. (Joachim), Engmann, J. (Jorgen), Gertow, K. (Karl), Rice, K.M. (Kenneth), Taylor, K.D. (Kent), Dhana, K. (Klodian), Kiemeney, L.A.L.M. (Lambertus A. L. M.), Kao, W.H.L. (Wen), Raffield, L.M. (Laura M.), Launer, L.J. (Lenore), Holdt, L.M. (Lesca), Dörr, M. (Marcus), Kubisch, C. (Christian), Traylor, M. (Matthew), Sitzer, M. (Matthias), Kumari, M. (Meena), Kivimaki, M. (Mika), Nalls, M.A. (Michael), Melander, O. (Olle), Raitakari, O. (Olli), Franco, O.H. (Oscar), Rueda-Ochoa, O.L. (Oscar), Roussos, A. (Alexandra), Whincup, P.H. (Peter), Amouyel, P. (Philippe), Giral, P. (Philippe), Anugu, P. (Pramod), Wong, Q. (Quenna), Malik, R. (Rainer), Rauramaa, R. (Rainer), Burkhardt, R. (Ralph), Hardy, R. (Rebecca), Schmidt, R. (Reinhold), Mutsert, R. (Reneé) de, Strawbridge, R.J. (Rona), Wannamethee, S.G. (Goya), Hägg, S. (Sara), Shah, S. (Sonia), McLachlan, S. (Stela), Trompet, S. (Stella), Seshadri, S. (Sudha), Kurl, S. (Sudhir), Heckbert, S.R. (Susan), Ring, S.M. (Susan), Harris, T.B. (Tamara B.), Lehtimäki, T. (Terho), Galesloot, T.E. (Tessel), Shah, T. (Tina), Faire, U. (Ulf) de, Plagnol, V. (Vincent), Rosamond, W.D. (Wayne), Post, W.S. (Wendy S.), Zhu, X. (Xiaofeng), Zhang, X. (Xiaoling), Guo, X. (Xiuqing), Saba, Y. (Yasaman), Okada, Y. (Yukinori), Mishra, A. (Aniket), Rutten-Jacobs, L. (Loes), Giese, A.-K. (Anne-Katrin), van der Laan, S.W. (Sander W.), Gretarsdottir, S. (Solveig), Anderson, C.D. (Christopher D.), Chong, M. (Michael), Adams, H.H.H. (Hieab), Ago, T. (Tetsuro), Almgren, P. (Peter), Ay, H. (Hakan), Bartz, T.M. (Traci M.), Benavente, O.R. (Oscar R.), Bevan, S. (Steve), Boncoraglio, G. (Giorgio Battista), Brown, R.D. (Robert D.), Butterworth, A.S. (Adam S.), Carrera, C. (Caty), Carty, C.L. (Cara L.), Chasman, D.I. (Daniel), Chen, W-M., Cole, J.W. (John W.), Cotlarciuc, I. (Ioana), Cruchaga, C. (Carlos), Danesh, J. (John), Bakker, P.I.W. (Paul) de, DeStefano, A.L. (Anita), Hoed, M. (Marcel) den, Duan, Q. (Qing), Engelter, S.T. (Stefan), Falcone, G.J. (Guido J.), Gottesman, R.F. (Rebecca), Grewal, R.P. (Raji P.), Gustafsson, S. (Stefan), Haessler, J. (Jeff), Harris, T.B. (Tamara), Hassan, A. (Ahamad), Havulinna, A.S. (Aki), Holliday, E.G. (Elizabeth), Howard, G. (George), Hsu, F.-C. (Fang-Chi), Hyacinth, H.I. (Hyacinth I.), Ikram, M.A. (Arfan), Irvin, M.R. (Marguerite R.), Jian, X. (Xueqiu), Jimenez-Conde, J. (Jordi), Johnson, J.A. (Julie A.), Jukema, J.W. (J. Wouter), Kanai, M. (Masahiro), Keene, K.L. (Keith), Kissela, B.M. (Brett M.), Kleindorfer, D.O. (Dawn O.), Kooperberg, C. (Charles), Kubo, M. (Michiaki), Lange, L.A. (Leslie), Langefeld, C.D. (Carl), Langenberg, C. (Claudia), Lee, J.-M. (Jin-Moo), Lemmens, R. (Robin), Leys, D. (Didier), Lewis, C.M. (Cathryn), Lin, W.-Y. (Wei-Yu), Lindgren, A.G. (Arne G.), Lorentzen, E. (Erik), Magnusson, P.K. (Patrik), Maguire, J.M. (Jane), Manichaikul, A. (Ani), McArdle, P.F. (Patrick), Meschia, J.F. (James F.), Mosley, T.H. (Thomas H.), Ninomiya, T. (Toshiharu), O’Donnell, M.J. (Martin J.), Pulit, S.L. (Sara), Rannikmäe, K. (Kristiina), Reiner, A.P. (Alexander P.), Rexrode, K. (Kathryn), Rich, S.S. (Stephen), Ridker, P.M. (Paul), Rost, N.S. (Natalia), Rothwell, P.M. (Peter), Rundek, T. (Tatjana), Muir, K.W. (Keith), Sakaue, S. (Saori), Sale, M.M. (Michele M.), Salomaa, V. (Veikko), Sapkota, B.R. (Bishwa R.), Schmidt, C.O. (Carsten O.), Sharma, P. (Pankaj), Slowik, A. (Agnieszka), Sudlow, C. (Cathie), Tanislav, C. (Christian), Tatlisumak, T. (Turgut), Thijs, V. (Vincent), Thorleifsson, G. (Gudmar), Thorsteinsdottir, U. (Unnur), Tiedt, S. (Steffen), Walters, M. (Matthew), Wareham, N.J. (Nick), Wassertheil-Smoller, S. (Sylvia), Wiggins, K.L. (Kerri), Yang, Q. (Qiong Fang), Yusuf, S. (Salim), Pastinen, T. (Tomi), Schadt, E.E. (Eric), Koplev, S. (Simon), Codoni, V. (Veronica), Civelek, M. (Mete), Smith, N.L. (Nicholas), Tregouet, D.-A. (David-Alexandre), Christophersen, I.E. (Ingrid E.), Roselli, C. (Carolina), Lubitz, S.A. (Steven A.), Ellinor, P.T. (Patrick), Tai, E.S. (E. Shyong), Kooner, J.S. (Jaspal S.), Kato, N. (Norihiro), He, J. (Jiang), Harst, P. (Pim) van der, Elliott, P. (Paul), Chambers, J.C. (John C.), Takeuchi, F. (Fumihiko), Johnson, A.D. (Andrew), Sanghera, D.K. (Dharambir K.), Jern, C. (Christina), Strbian, D. (Daniel), Fernandez-Cadenas, I. (Israel), Longstreth Jr, W.T., Rolfs, A. (Arndt), Hata, J. (Jun), Woo, D. (Daniel), Rosand, J. (Jonathan), Pare, G. (Guillame), Saleheen, D. (Danish), Zwart, J-A. (John-Anker), Worrall, B.B. (Bradford B.), Kittner, T. (Thomas), Howson, J.M.M. (Joanna M. M.), Kamatani, Y. (Yoichiro), Dehghan, A. (Abbas), Seldenrijk, K.A. (Kees), Morrison, A.C. (Alanna), Hamsten, A. (Anders), Psaty, B.M. (Bruce), Duijn, C.M. (Cornelia) van, Lawlor, D.A. (Debbie), Mook-Kanamori, D.O. (Dennis O.), Bowden, D.W. (Donald), Schmidt, H. (Helena), Wilson, J.F. (James F.), Wilson, J.F. (James), Rotter, J.I. (Jerome I.), Wardlaw, J.M. (J.), Deanfield, J. (John), Halcox, J. (Julian), Lyytikäinen, L.-P. (Leo-Pekka), Loeffler, M. (Markus), Evans, M.K. (Michele), Debette, S. (Stéphanie), Humphries, S.E. (Steve), Völker, U. (Uwe), Gudnason, V. (Vilmundur), Hingorani, A. (Aroon), Björkegren, J.L.M. (Johan L.M.), Casas, J.P. (Juan), Ódonnell, C.J. (Christopher), and Morris, R.W. (Richard)
Abstract: Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans.
Published: 2018
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9. Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

Author: Bis, J.C. (Joshua), Jian, X. (Xueqiu), Kunkle, B.W. (Brian W.), Chen, Y. (Yuning), Hamilton-Nelson, K.L. (Kara L.), Bush, W.S. (William S.), Salerno, W.J. (William J.), Lancour, D. (Daniel), Ma, Y. (Yiyi), Renton, A. (Alan), Marcora, E. (Edoardo), Farrell, J.J. (John J.), Zhao, Y. (Yi), Qu, L. (Liming), Ahmad, S. (Shahzad), Amin, N. (Najaf), Amouyel, P. (Philippe), Beecham, G.W., Below, J.E. (Jennifer E.), Campion, D. (Dominique), Charbonnier, C. (Camille), Chung, J. (Jaeyoon), Crane, L.M.A., Cruchaga, C. (Carlos), Cupples, L.A. (L. Adrienne), Dartigues, J.-F., Debette, S. (Stéphanie), Deleuze, J.-F. (Jean-François), Fulton, L. (Lucinda), Gabriel, S.B. (Stacey), Genin, E. (Emmanuelle), Gibbs, R.A. (Richard A.), Goate, A.M. (Alison), Grenier-Boley, B. (Benjamin), Gupta, N. (Namrata), Haines, J.L. (Jonathan), Havulinna, A.S. (Aki), Helisalmi, S. (Seppo), Hiltunen, M. (Mikko), Howrigan, D.P. (Daniel P.), Ikram, M.A. (Arfan), Kaprio, J. (Jaakko), Konrad, J. (Jan), Kuzma, A. (Amanda), Lander, E.S. (Eric), Lathrop, M. (Mark), Lehtimäki, T. (Terho), Lin, H. (Honghuang), Mattila, K. (Kari), Mayeux, R. (Richard), Muzny, D. (Donna), Nasser, W. (Waleed), Neale, B.M. (Benjamin), Nho, K. (Kwangsik), Nicolas, G. (Gaël), Patel, D. (Devanshi), Pericak-Vance, M.A. (Margaret), Perola, M. (Markus), Psaty, B.M. (Bruce M.), Quenez, O. (Olivier), Rajabli, F. (Farid), Redon, R. (Richard), Reitz, C. (Christiane), Remes, A. (Anne), Salomaa, V. (Veikko), Sarnowski, C., Schmidt, H. (Helena), Schmidt, M. (Michael), Schmidt, R. (Reinhold), Soininen, H. (H.), Thornton, T.A. (Timothy A.), Tosto, G. (G.), Tzourio, C. (Christophe), Lee, S.J. (Sven) van der, Duijn, C.M. (Cornelia) van, Vardarajan, B.N. (Badri), Wang, W. (Weixin), Wijsman, E.M. (Ellen), Wilson, R.K. (Richard K.), Witten, D. (Daniela), Worley, K.C. (Kim C.), Zhang, X. (Xiaoling), Bellenguez, C. (Céline), Lambert, J.-C. (J.), Kurki, M.I. (Mitja I.), Palotie, A. (Aarno), Daly, M. (Mark), Boerwinkle, E. (Eric), Lunetta, K.L. (Kathryn), DeStefano, A.L. (Anita), Dupuis, J. (Josée), Martin, E.R. (Eden R.), Schellenberg, G.D. (Gerard), Seshadri, S. (Sudha), Naj, A.C. (Adam C.), Fornage, M. (Myriam), Farrer, L.A. (Lindsay), Bis, J.C. (Joshua), Jian, X. (Xueqiu), Kunkle, B.W. (Brian W.), Chen, Y. (Yuning), Hamilton-Nelson, K.L. (Kara L.), Bush, W.S. (William S.), Salerno, W.J. (William J.), Lancour, D. (Daniel), Ma, Y. (Yiyi), Renton, A. (Alan), Marcora, E. (Edoardo), Farrell, J.J. (John J.), Zhao, Y. (Yi), Qu, L. (Liming), Ahmad, S. (Shahzad), Amin, N. (Najaf), Amouyel, P. (Philippe), Beecham, G.W., Below, J.E. (Jennifer E.), Campion, D. (Dominique), Charbonnier, C. (Camille), Chung, J. (Jaeyoon), Crane, L.M.A., Cruchaga, C. (Carlos), Cupples, L.A. (L. Adrienne), Dartigues, J.-F., Debette, S. (Stéphanie), Deleuze, J.-F. (Jean-François), Fulton, L. (Lucinda), Gabriel, S.B. (Stacey), Genin, E. (Emmanuelle), Gibbs, R.A. (Richard A.), Goate, A.M. (Alison), Grenier-Boley, B. (Benjamin), Gupta, N. (Namrata), Haines, J.L. (Jonathan), Havulinna, A.S. (Aki), Helisalmi, S. (Seppo), Hiltunen, M. (Mikko), Howrigan, D.P. (Daniel P.), Ikram, M.A. (Arfan), Kaprio, J. (Jaakko), Konrad, J. (Jan), Kuzma, A. (Amanda), Lander, E.S. (Eric), Lathrop, M. (Mark), Lehtimäki, T. (Terho), Lin, H. (Honghuang), Mattila, K. (Kari), Mayeux, R. (Richard), Muzny, D. (Donna), Nasser, W. (Waleed), Neale, B.M. (Benjamin), Nho, K. (Kwangsik), Nicolas, G. (Gaël), Patel, D. (Devanshi), Pericak-Vance, M.A. (Margaret), Perola, M. (Markus), Psaty, B.M. (Bruce M.), Quenez, O. (Olivier), Rajabli, F. (Farid), Redon, R. (Richard), Reitz, C. (Christiane), Remes, A. (Anne), Salomaa, V. (Veikko), Sarnowski, C., Schmidt, H. (Helena), Schmidt, M. (Michael), Schmidt, R. (Reinhold), Soininen, H. (H.), Thornton, T.A. (Timothy A.), Tosto, G. (G.), Tzourio, C. (Christophe), Lee, S.J. (Sven) van der, Duijn, C.M. (Cornelia) van, Vardarajan, B.N. (Badri), Wang, W. (Weixin), Wijsman, E.M. (Ellen), Wilson, R.K. (Richard K.), Witten, D. (Daniela), Worley, K.C. (Kim C.), Zhang, X. (Xiaoling), Bellenguez, C. (Céline), Lambert, J.-C. (J.), Kurki, M.I. (Mitja I.), Palotie, A. (Aarno), Daly, M. (Mark), Boerwinkle, E. (Eric), Lunetta, K.L. (Kathryn), DeStefano, A.L. (Anita), Dupuis, J. (Josée), Martin, E.R. (Eden R.), Schellenberg, G.D. (Gerard), Seshadri, S. (Sudha), Naj, A.C. (Adam C.), Fornage, M. (Myriam), and Farrer, L.A. (Lindsay)
Abstract: The Alzheimer’s Disease Sequencing Project (ADSP) undertook whole exome sequencing in 5,740 late-onset Alzheimer disease (AD) cases and 5,096 cognitively normal controls primarily of European ancestry (EA), among whom 218 cases and 177 controls were Caribbean Hispanic (CH). An age-, sex- and APOE based risk score and family history were used to select cases most likely to harbor novel AD risk variants and controls least likely to develop AD by age 85 years. We tested ~1.5 million single nucleotide variants (SNVs) and 50,000 insertion-deletion polymorphisms (indels) for association to AD, using multiple models considering individual variants as well as gene-based tests aggregating rare, predicted functional, and loss of function variants. Sixteen single variants and 19 genes that met criteria for significant or suggestive associations after multiple-testing correction were evaluated for replication in four independent samples; three with whole exome sequencing (2,778 cases, 7,262 contro
Published: 2018
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10. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author: Davies, G. (Gail), Lam, M. (Max), Harris, S.E. (Sarah), Trampush, J.W. (Joey W.), Luciano, M. (Michelle), Hill, W.D. (W. David), Hagenaars, S. (Saskia), Ritchie, S.J. (Stuart J.), Marioni, R.E. (Riccardo), Fawns-Ritchie, C., Liewald, D.C.M. (David C. M.), Okely, J.A. (Judith A.), Ahola-Olli, A.V. (Ari V.), Barnes, C.L.K. (Catriona L. K.), Bertram, L. (Lars), Bis, J.C. (Joshua), Burdick, K.E. (Katherine E.), Christoforou, A. (Andrea), Derosse, P. (Pamela), Djurovic, S. (Srdjan), Espeseth, T. (Thomas), Giakoumaki, S. (Stella), Giddaluru, S. (Sudheer), Gustavson, D.E. (Daniel E.), Hayward, C. (Caroline), Hofer, E. (Edith), Ikram, M.A. (Arfan), Karlsson, R. (Robert), Knowles, E. (Emma), Lahti, J. (Jari), Leber, I. (Isabelle), Li, S. (Shuo), Mather, R., Melle, I. (Ingrid), Morris, D. (Derek), Oldmeadow, C. (Christopher), Palviainen, T. (Teemu), Payton, A. (Antony), Pazoki, R. (Raha), Petrovic, K. (Katja), Reynolds, C.A. (C.), Sargurupremraj, M. (Muralidharan), Scholz, M. (Markus), Smith, J.A. (Jennifer A), Smith, A.V. (Albert), Terzikhan, N. (Natalie), Thalamuthu, A. (Anbupalam), Trompet, S. (Stella), Lee, S.J. (Sven) van der, Ware, E.B. (Erin B.), Windham, B.G. (Gwen), Wright, M.J. (Margaret J.), Yang, J. (Jingyun), Yu, J. (Jin), Ames, D.J. (David), Amin, N. (Najaf), Amouyel, P. (Philippe), Andreassen, O.A. (Ole), Armstrong, N.J. (Nicola J.), Assareh, A.A., Attia, J. (John), Attix, D. (Deborah), Avramopoulos, D. (Dimitrios), Bennett, D.A. (David), Böhmer, M.R. (Marcel), Boyle, P.A. (Patricia A.), Brodaty, H. (Henry), Campbell, H. (Harry), Cannon, T.D. (Tyrone D.), Cirulli, E.T. (Elizabeth T.), Congdon, E. (Eliza), Conley, E.D. (Emily Drabant), Corley, J. (Janie), Cox, S.R. (Simon R.), Dale, A.M. (Anders), Dehghan, A. (Abbas), Dick, D. (Danielle), Dickinson, D. (Dwight), Hagen, K. (Knut), Evangelou, E. (Evangelos), Faul, J.D. (Jessica D.), Ford, I. (Ian), Freimer, N.A. (Nelson A.), Gao, H. (He), Giegling, I. (Ina), Gillespie, N.A. (Nathan A.), Gordon, S.D. (Scott D.), Gottesman, R.F. (Rebecca), Griswold, M.D. (Michael), Gudnason, V. (Vilmundur), Harris, T.B. (Tamara), Hartmann, A.M. (Annette M), Hatzimanolis, A. (Alex), Heiss, G. (Gerardo), Holliday, E.G. (Elizabeth), Joshi, P.K. (Peter), Kähönen, M. (Mika), Kardia, S.L.R. (Sharon L. R.), Karlsson, I. (Ida), Kleineidam, L. (Luca), Knopman, D.S. (David), Kochan, N.A. (Nicole A.), Konte, B. (Bettina), Kwok, J.B.J. (John), Le Hellard, S. (Stephanie), Lee, T. (Teresa), Lehtimäki, T. (Terho), Li, S.-C. (Shu-Chen), Liu, T. (Tian), Koini, M. (Marisa), London, E. (Edythe), Longstreth Jr, W.T., Lopez, O.L. (Oscar), Loukola, A. (Anu), Luck, T. (Tobias), Lundervold, A.J. (Astri), Lundquist, A. (Anders), Lyytikäinen, L.-P. (Leo-Pekka), Martin, N.G. (Nicholas), Montgomery, G.W. (Grant W.), Murray, A.D. (Alison D.), Need, A.C. (Anna C.), Noordam, R. (Raymond), Nyberg, L. (Lisa), Ollier, W.E.R. (William), Papenberg, G., Pattie, A. (Alison), Polasek, O. (Ozren), Poldrack, R.A. (Russell A.), Psaty, B.M. (Bruce M.), Reppermund, S., Riedel-Heller, S. (Steffi), Rose, R.J. (Richard), Rotter, J.I. (Jerome I.), Roussos, A. (Alexandra), Rovio, S.P. (Suvi P.), Saba, Y. (Yasaman), Sabb, F.W. (Fred W.), Sachdev, P.S. (Perminder), Satizabal, C.L. (Claudia), Schmid, M. (Matthias), Scott, R.J. (Rodney J.), Scult, M.A. (Matthew A.), Simino, J. (Jeannette), Slagboom, P.E. (Eline), Smyrnis, N. (Nikolaos), Soumaré, A. (Aicha), Stefanis, N.C. (Nikos C.), Stott, D.J. (David. J.), Straub, R.E. (Richard), Sundet, K. (Kjetil), Taylor, A.M. (Adele M.), Taylor, K.D. (Kent), Tzoulaki, I., Tzourio, C. (Christophe), Uitterlinden, A.G. (André), Vitart, V. (Veronique), Voineskos, A.N. (Aristotle N.), Kaprio, J. (Jaakko), Wagner, M. (Michael), Wagner, H. (Hermann), Weinhold, L. (Leonie), Wen, K.H. (K. Hoyan), Widen, E., Yang, Q. (Qiong Fang), Zhao, W. (Wei), Adams, H.H.H. (Hieab), Arking, D.E. (Dan), Bilder, R.M. (Robert M.), Bitsios, P. (Panos), Boerwinkle, E. (Eric), Chiba-Falek, O. (Ornit), Corvin, A. (Aiden), Jager, P.L. (Philip) de, Debette, S. (Stéphanie), Donohoe, D.J. (Dennis), Elliott, P. (Paul), Fitzpatrick, A.L. (Annette), Gill, M. (Michael), Glahn, D.C. (David), Hägg, S. (Sara), Hansell, N.K. (Narelle), Hariri, A.R. (Ahmad), Ikram, M.K. (Kamran), Jukema, J.W. (Jan Wouter), Vuoksimaa, E. (Eero), Keller, M.C. (Matthew C), Kremen, W.S. (William S.), Launer, L.J. (Lenore), Lindenberger, U. (Ulman), Palotie, A. (Aarno), Pedersen, N.L. (Nancy), Pendleton, N. (Neil), Porteous, D.J. (David J.), Räikkönen, K. (Katri), Raitakari, O.T. (Olli T.), Ramirez, A. (Alfredo), Reinvang, I. (Ivar), Rudan, I. (Igor), Rujescu, D. (Dan), Schmidt, R. (Reinhold), Schmidt, H. (Helena), Schofield, P.W. (Peter W.), Schofield, C.J. (Christopher), Starr, J.M. (John), Steen, V.M. (Vidar), Trollor, J., Turner, S.T. (Steven T.), Duijn, C.M. (Cornelia) van, Villringer, A. (Arno), Weinberger, D.R. (Daniel), Weir, D.R. (David R.), Wilson, J.F. (James F.), Malhotra, A.K. (Anil K), McIntosh, A.M. (Andrew), Gale, C.R. (Catharine R.), Seshadri, S. (Sudha), Mosley, T.H. (Thomas H.), Bressler, J. (Jan), Lencz, T. (Todd), Deary, I.J. (Ian), Davies, G. (Gail), Lam, M. (Max), Harris, S.E. (Sarah), Trampush, J.W. (Joey W.), Luciano, M. (Michelle), Hill, W.D. (W. David), Hagenaars, S. (Saskia), Ritchie, S.J. (Stuart J.), Marioni, R.E. (Riccardo), Fawns-Ritchie, C., Liewald, D.C.M. (David C. M.), Okely, J.A. (Judith A.), Ahola-Olli, A.V. (Ari V.), Barnes, C.L.K. (Catriona L. K.), Bertram, L. (Lars), Bis, J.C. (Joshua), Burdick, K.E. (Katherine E.), Christoforou, A. (Andrea), Derosse, P. (Pamela), Djurovic, S. (Srdjan), Espeseth, T. (Thomas), Giakoumaki, S. (Stella), Giddaluru, S. (Sudheer), Gustavson, D.E. (Daniel E.), Hayward, C. (Caroline), Hofer, E. (Edith), Ikram, M.A. (Arfan), Karlsson, R. (Robert), Knowles, E. (Emma), Lahti, J. (Jari), Leber, I. (Isabelle), Li, S. (Shuo), Mather, R., Melle, I. (Ingrid), Morris, D. (Derek), Oldmeadow, C. (Christopher), Palviainen, T. (Teemu), Payton, A. (Antony), Pazoki, R. (Raha), Petrovic, K. (Katja), Reynolds, C.A. (C.), Sargurupremraj, M. (Muralidharan), Scholz, M. (Markus), Smith, J.A. (Jennifer A), Smith, A.V. (Albert), Terzikhan, N. (Natalie), Thalamuthu, A. (Anbupalam), Trompet, S. (Stella), Lee, S.J. (Sven) van der, Ware, E.B. (Erin B.), Windham, B.G. (Gwen), Wright, M.J. (Margaret J.), Yang, J. (Jingyun), Yu, J. (Jin), Ames, D.J. (David), Amin, N. (Najaf), Amouyel, P. (Philippe), Andreassen, O.A. (Ole), Armstrong, N.J. (Nicola J.), Assareh, A.A., Attia, J. (John), Attix, D. (Deborah), Avramopoulos, D. (Dimitrios), Bennett, D.A. (David), Böhmer, M.R. (Marcel), Boyle, P.A. (Patricia A.), Brodaty, H. (Henry), Campbell, H. (Harry), Cannon, T.D. (Tyrone D.), Cirulli, E.T. (Elizabeth T.), Congdon, E. (Eliza), Conley, E.D. (Emily Drabant), Corley, J. (Janie), Cox, S.R. (Simon R.), Dale, A.M. (Anders), Dehghan, A. (Abbas), Dick, D. (Danielle), Dickinson, D. (Dwight), Hagen, K. (Knut), Evangelou, E. (Evangelos), Faul, J.D. (Jessica D.), Ford, I. (Ian), Freimer, N.A. (Nelson A.), Gao, H. (He), Giegling, I. (Ina), Gillespie, N.A. (Nathan A.), Gordon, S.D. (Scott D.), Gottesman, R.F. (Rebecca), Griswold, M.D. (Michael), Gudnason, V. (Vilmundur), Harris, T.B. (Tamara), Hartmann, A.M. (Annette M), Hatzimanolis, A. (Alex), Heiss, G. (Gerardo), Holliday, E.G. (Elizabeth), Joshi, P.K. (Peter), Kähönen, M. (Mika), Kardia, S.L.R. (Sharon L. R.), Karlsson, I. (Ida), Kleineidam, L. (Luca), Knopman, D.S. (David), Kochan, N.A. (Nicole A.), Konte, B. (Bettina), Kwok, J.B.J. (John), Le Hellard, S. (Stephanie), Lee, T. (Teresa), Lehtimäki, T. (Terho), Li, S.-C. (Shu-Chen), Liu, T. (Tian), Koini, M. (Marisa), London, E. (Edythe), Longstreth Jr, W.T., Lopez, O.L. (Oscar), Loukola, A. (Anu), Luck, T. (Tobias), Lundervold, A.J. (Astri), Lundquist, A. (Anders), Lyytikäinen, L.-P. (Leo-Pekka), Martin, N.G. (Nicholas), Montgomery, G.W. (Grant W.), Murray, A.D. (Alison D.), Need, A.C. (Anna C.), Noordam, R. (Raymond), Nyberg, L. (Lisa), Ollier, W.E.R. (William), Papenberg, G., Pattie, A. (Alison), Polasek, O. (Ozren), Poldrack, R.A. (Russell A.), Psaty, B.M. (Bruce M.), Reppermund, S., Riedel-Heller, S. (Steffi), Rose, R.J. (Richard), Rotter, J.I. (Jerome I.), Roussos, A. (Alexandra), Rovio, S.P. (Suvi P.), Saba, Y. (Yasaman), Sabb, F.W. (Fred W.), Sachdev, P.S. (Perminder), Satizabal, C.L. (Claudia), Schmid, M. (Matthias), Scott, R.J. (Rodney J.), Scult, M.A. (Matthew A.), Simino, J. (Jeannette), Slagboom, P.E. (Eline), Smyrnis, N. (Nikolaos), Soumaré, A. (Aicha), Stefanis, N.C. (Nikos C.), Stott, D.J. (David. J.), Straub, R.E. (Richard), Sundet, K. (Kjetil), Taylor, A.M. (Adele M.), Taylor, K.D. (Kent), Tzoulaki, I., Tzourio, C. (Christophe), Uitterlinden, A.G. (André), Vitart, V. (Veronique), Voineskos, A.N. (Aristotle N.), Kaprio, J. (Jaakko), Wagner, M. (Michael), Wagner, H. (Hermann), Weinhold, L. (Leonie), Wen, K.H. (K. Hoyan), Widen, E., Yang, Q. (Qiong Fang), Zhao, W. (Wei), Adams, H.H.H. (Hieab), Arking, D.E. (Dan), Bilder, R.M. (Robert M.), Bitsios, P. (Panos), Boerwinkle, E. (Eric), Chiba-Falek, O. (Ornit), Corvin, A. (Aiden), Jager, P.L. (Philip) de, Debette, S. (Stéphanie), Donohoe, D.J. (Dennis), Elliott, P. (Paul), Fitzpatrick, A.L. (Annette), Gill, M. (Michael), Glahn, D.C. (David), Hägg, S. (Sara), Hansell, N.K. (Narelle), Hariri, A.R. (Ahmad), Ikram, M.K. (Kamran), Jukema, J.W. (Jan Wouter), Vuoksimaa, E. (Eero), Keller, M.C. (Matthew C), Kremen, W.S. (William S.), Launer, L.J. (Lenore), Lindenberger, U. (Ulman), Palotie, A. (Aarno), Pedersen, N.L. (Nancy), Pendleton, N. (Neil), Porteous, D.J. (David J.), Räikkönen, K. (Katri), Raitakari, O.T. (Olli T.), Ramirez, A. (Alfredo), Reinvang, I. (Ivar), Rudan, I. (Igor), Rujescu, D. (Dan), Schmidt, R. (Reinhold), Schmidt, H. (Helena), Schofield, P.W. (Peter W.), Schofield, C.J. (Christopher), Starr, J.M. (John), Steen, V.M. (Vidar), Trollor, J., Turner, S.T. (Steven T.), Duijn, C.M. (Cornelia) van, Villringer, A. (Arno), Weinberger, D.R. (Daniel), Weir, D.R. (David R.), Wilson, J.F. (James F.), Malhotra, A.K. (Anil K), McIntosh, A.M. (Andrew), Gale, C.R. (Catharine R.), Seshadri, S. (Sudha), Mosley, T.H. (Thomas H.), Bressler, J. (Jan), Lencz, T. (Todd), and Deary, I.J. (Ian)
Abstract: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the c
Published: 2018
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11. Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium

Author: Chibnik, L.B. (Lori), Wolters, F.J. (Frank), Bäckman, K. (Kristoffer), Beiser, A. (Alexa), Berr, C. (Claudine), Bis, J.C. (Joshua), Boerwinkle, E. (Eric), Bos, D. (Daniel), Brayne, C. (Carol), Dartigues, J.-F., Darweesh, S.K.L. (Sirwan), Debette, S. (Stéphanie), Davis-Plourde, K.L. (Kendra L.), Dufouil, C. (Carole), Fornage, M. (Myriam), Grasset, L. (Leslie), Gudnason, V. (Vilmundur), Hadjichrysanthou, C. (Christoforos), Helmer, C. (Catherine), Ikram, M.K. (Kamran), Kern, S. (Silke), Kuller, L.H. (Lewis), Launer, L.J. (Lenore), Lopez, O.L. (Oscar), Matthews, F. (Fiona), Meirelles, O., Mosley, T.H. (Thomas H.), Ower, A. (Alison), Psaty, B.M. (Bruce M.), Satizabal, C.L. (Claudia), Seshadri, S. (Sudha), Skoog, I., Stephan, B.C.M., Tzourio, C. (Christophe), Waziry, R. (Reem), Wong, M.M. (Mei Mei), Zettergren, A. (Anna), Hofman, A. (Albert), Chibnik, L.B. (Lori), Wolters, F.J. (Frank), Bäckman, K. (Kristoffer), Beiser, A. (Alexa), Berr, C. (Claudine), Bis, J.C. (Joshua), Boerwinkle, E. (Eric), Bos, D. (Daniel), Brayne, C. (Carol), Dartigues, J.-F., Darweesh, S.K.L. (Sirwan), Debette, S. (Stéphanie), Davis-Plourde, K.L. (Kendra L.), Dufouil, C. (Carole), Fornage, M. (Myriam), Grasset, L. (Leslie), Gudnason, V. (Vilmundur), Hadjichrysanthou, C. (Christoforos), Helmer, C. (Catherine), Ikram, M.K. (Kamran), Kern, S. (Silke), Kuller, L.H. (Lewis), Launer, L.J. (Lenore), Lopez, O.L. (Oscar), Matthews, F. (Fiona), Meirelles, O., Mosley, T.H. (Thomas H.), Ower, A. (Alison), Psaty, B.M. (Bruce M.), Satizabal, C.L. (Claudia), Seshadri, S. (Sudha), Skoog, I., Stephan, B.C.M., Tzourio, C. (Christophe), Waziry, R. (Reem), Wong, M.M. (Mei Mei), Zettergren, A. (Anna), and Hofman, A. (Albert)
Abstract: Several studies have reported a decline in incidence of dementia which may have large implications for the projected burden of disease, and provide important guidance to preventive efforts. However, reports are conflicting or inconclusive with regard to the impact of gender and education with underlying causes of a presumed declining trend remaining largely unidentified. The Alzheimer Cohorts Consortium aggregates data from nine international population-based cohorts to determine changes in the incidence of dementia since 1990. We will employ Poisson regression models to calculate incidence rates in each cohort and Cox proportional hazard regression to compare 5-year cumulative hazards across study-specific epochs. Finally, we will meta-analyse changes per decade across cohorts, and repeat all analysis stratified by sex, education and APOE genotype. In all cohorts combined, there are data on almost 69,000 people at risk of dementia with the range of follow-up years between 2 and 27. The average age at baseline is similar across cohorts ranging between 72 and 77. Uniting a wide range of disease-specific and methodological expertise in research teams, the first analyses within the Alzheimer Cohorts Consortium are underway to tackle outstanding challenges in the assessment of time-trends in dementia occurrence.
Published: 2017
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12. Novel genetic loci associated with hippocampal volume

Author: Hibar, D.P. (Derrek), Adams, H.H.H. (Hieab), Jahanshad, N. (Neda), Chauhan, G. (Ganesh), Stein, J.L., Hofer, E. (Edith), Rentería, M.E. (Miguel), Bis, J.C. (Joshua), Arias-Vásquez, A. (Alejandro), Ikram, M.K. (M. Kamran), Desrivières, S. (Sylvane), Vernooij, M.W. (Meike), Abramovic, L. (Lucija), Alhusaini, S. (Saud), Amin, N. (Najaf), Andersson, M. (Micael), Arfanakis, K. (Konstantinos), Aribisala, B. (Benjamin), Armstrong, N.J. (Nicola J.), Athanasiu, L. (Lavinia), Axelsson, T. (Tomas), Beecham, A.H. (Ashley), Beiser, A. (Alexa), Bernard, M. (Manon), Blanton, S.H. (Susan H.), Bohlken, M.M. (Marc M.), Boks, M.P.M. (Marco), Bralten, L.B.C. (Linda), Brickman, A.M. (Adam M.), Carmichael, O. (Owen), Chakravarty, M.M. (M. Mallar), Chen, Q. (Qiang), Ching, C.R.K. (Christopher), Chouraki, V. (Vincent), Cuellar-Partida, G. (Gabriel), Crivello, F. (Fabrice), Braber, A. (Anouk) den, Doan, N.T. (Nhat Trung), Ehrlich, S.M. (Stefan), Giddaluru, S. (Sudheer), Goldman, A.L. (Aaron L.), Gottesman, R.F. (Rebecca), Grimm, O. (Oliver), Griswold, M.D. (Michael), Guadalupe, T. (Tulio), Gutman, B.A. (Boris A.), Hass, J. (Johanna), Haukvik, U.K. (Unn), Hoehn, D. (David), Holmes, A.J. (Avram), Hoogman, M. (Martine), Janowitz, D. (Deborah), Jia, T. (Tianye), Jørgensen, K.N. (Kjetil N.), Karbalai, N. (Nazanin), Kasperaviciute, D. (Dalia), Kim, S. (Shinseog), Klein, M. (Marieke), Kraemer, B. (Bernd), Lee, P.H. (Phil), Liewald, D.C.M. (David), Lopez, L.M. (Lorna), Luciano, M. (Michelle), MacAre, C. (Christine), Marquand, A.F. (Andre F.), Matarin, M. (Mar), Mather, R., Mattheisen, M. (Manuel), McKay, D.R. (David R.), Milaneschi, Y. (Yuri), Muñoz Maniega, S. (Susana), Nho, K. (Kwangsik), Nugent, A.C. (Allison), Nyquist, P. (Paul), Loohuis, L.M.O. (Loes M. Olde), Oosterlaan, J. (Jaap), Papmeyer, M. (Martina), Pirpamer, L. (Lukas), Pütz, B. (Benno), Ramasamy, A. (Adaikalavan), Richards, J.S. (Jennifer S.), Risacher, S.L. (Shannon), Roiz-Santiañez, R. (Roberto), Rommelse, N. (Nanda), Ropele, S. (Stefan), Rose, E.J. (Emma), Royle, N.A. (Natalie), Rundek, T. (Tatjana), Sämann, P.G. (Philipp), Saremi, A. (Arvin), Satizabal, C.L. (Claudia), Schmaal, L. (Lianne), Schork, N.J. (Nicholas), Shen, L. (Li), Shin, J. (Jean), Shumskaya, E. (Elena), Smith, A.V. (Albert Vernon), Sprooten, R. (Roy), Strike, L.T. (Lachlan), Teumer, A. (Alexander), Tordesillas-Gutierrez, D. (Diana), Toro, R. (Roberto), Trabzuni, D. (Danyah), Trompet, S. (Stella), Vaidya, D. (Dhananjay), van der Grond, J. (Jeroen), Lee, S.J. (Sven) van der, Van Der Meer, D. (Dennis), Van Donkelaar, M.M.J. (Marjolein M. J.), Eijk, K.R. (Kristel) van, Erp, T.G.M. (Theo G.) van, Van Rooij, D. (Daan), Walton, E. (Esther), Westlye, L.T. (Lars), Whelan, C.D. (Christopher), Windham, B.G. (Gwen), Winkler, A.M. (Anderson), Wittfeld, K. (Katharina), Woldehawariat, G. (Girma), Björnsson, A. (Asgeir), Wolfers, T. (Thomas), Yanek, L.R. (Lisa), Yang, J. (Jingyun), Zijdenbos, A.P., Zwiers, M.P. (Marcel), Agartz, I. (Ingrid), Almasy, L. (Laura), Ames, D.J. (David), Amouyel, P. (Philippe), Andreassen, O.A. (Ole), Arepalli, S. (Sampath), Assareh, A.A., Barral, S. (Sandra), Bastin, M.E. (Mark), Becker, D.M. (Diane M.), Becker, J.T. (James), Bennett, D.A. (David A.), Blangero, J. (John), Bokhoven, H. (Hans) van, Boomsma, D.I. (Dorret), Brodaty, H. (Henry), Brouwer, R.M. (Rachel), Brunner, H.G., Buckner, M., Buitelaar, J.K. (Jan), Bulayeva, K. (Kazima), Cahn, W. (Wiepke), Calhoun, V.D. (Vince), Cannon, D.M. (Dara), Cavalleri, G. (Gianpiero), Cheng, C.-Y. (Ching-Yu), Cichon, S. (Sven), Cookson, M.R. (Mark), Corvin, A. (Aiden), Crespo-Facorro, B. (Benedicto), Curran, J.E. (Joanne), Czisch, M. (Michael), Dale, A.M. (Anders), Davies, G.E. (Gareth), Craen, A.J. (Anton) de, Geus, E.J.C. (Eco) de, Jager, P.L. (Philip) de, Zubicaray, G.I. (Greig) de, Deary, I.J. (Ian), Debette, S. (Stéphanie), DeCarli, C. (Charles), Delanty, N., Depondt, C. (Chantal), DeStefano, A.L. (Anita), Dillman, A. (Allissa), Djurovic, S. (Srdjan), Donohoe, D.J. (Dennis), Drevets, D.A. (Douglas), Duggirala, R. (Ravi), Dyer, M.D. (Matthew), Enzinger, C. (Christian), Erk, S., Espeseth, T. (Thomas), Fedko, I.O. (Iryna O.), Fernández, G. (Guillén), Ferrucci, L. (Luigi), Fisher, S.E. (Simon), Fleischman, D. (Debra), Ford, I. (Ian), Fornage, M. (Myriam), Foroud, T. (Tatiana), Fox, P.T. (Peter), Francks, C. (Clyde), Fukunaga, M. (Masaki), Gibbs, J.R. (J. Raphael), Glahn, D.C. (David), Gollub, R.L. (Randy), Göring, H.H.H. (Harald H.), Green, R.C. (Robert C.), Gruber, O. (Oliver), Gudnason, V. (Vilmundur), Guelfi, S. (Sebastian), Håberg, A.K. (Asta K.), Hansell, N.K. (Narelle), Hardy, J. (John), Hartman, C.A. (C.), Hashimoto, R. (Ryota), Hegenscheid, K. (Katrin), Heinz, J. (Judith), Le Hellard, S. (Stephanie), Hernandez, D.G. (Dena), Heslenfeld, D.J. (Dirk), Ho, B.-C. (Beng-Choon), Hoekstra, P.J. (Pieter), Hoffmann, W. (Wolfgang), Hofman, A. (Albert), Holsboer, F. (Florian), Homuth, G. (Georg), Hosten, N. (Norbert), Hottenga, J.J. (Jouke Jan), Huentelman, M.J. (Matthew), Pol, H.H., Ikeda, M. (Masashi), Jack, C.R. (Clifford R.), Jenkinson, S. (Sarah), Johnson, R. (Robert), Jönsson, E.G. (Erik G.), Jukema, J.W., Kahn, R. (René), Kanai, R. (Ryota), Kloszewska, I. (Iwona), Knopman, D.S. (David S.), Kochunov, P. (Peter), Kwok, J.B. (John B.), Lawrie, S. (Stephen), Lemaître, H. (Herve), Liu, X. (Xinmin), Longo, D.L. (Dan L.), Lopez, O.L. (Oscar L.), Lovestone, S. (Simon), Martinez, O. (Oliver), Martinot, J.-L. (Jean-Luc), Mattay, V.S. (Venkata S.), McDonald, C. (Colm), McIntosh, A.M. (Andrew), McMahon, F.J. (Francis J.), McMahon, K.L. (Katie L.), Mecocci, P. (Patrizia), Melle, I. (Ingrid), Meyer-Lindenberg, A. (Andreas), Mohnke, S. (Sebastian), Montgomery, G.W. (Grant W.), Morris, D.W. (Derek W), Mosley, T.H. (Thomas H.), Mühleisen, T.W. (Thomas), Müller-Myhsok, B. (B.), Nalls, M.A. (Michael), Nauck, M. (Matthias), Nichols, T.E. (Thomas), Niessen, W.J. (Wiro), Nöthen, M.M. (Markus), Nyberg, L. (Lars), Ohi, K. (Kazutaka), Olvera, R.L. (Rene), Ophoff, R.A. (Roel), Pandolfo, M. (Massimo), Paus, T. (Tomas), Pausova, Z. (Zdenka), Penninx, B.W.J.H. (Brenda), Pike, G.B. (G. Bruce), Potkin, S.G. (Steven), Psaty, B.M. (Bruce), Reppermund, S., Rietschel, M. (Marcella), Roffman, J.L. (Joshua), Seiferth, N. (Nina), Rotter, J.I. (Jerome I.), Ryten, M. (Mina), Sacco, R.L. (Ralph L.), Sachdev, P.S. (Perminder), Saykin, A.J. (Andrew), Schmidt, R. (Reinhold), Schmidt, H. (Helena), Schofield, C.J. (Christopher), Sigursson, S. (Sigurdur), Simmons, A. (Andrew), Singleton, A. (Andrew), Sisodiya, S.M. (Sanjay), Smith, C. (Colin), Smoller, J.W., Soininen, H. (H.), Steen, V.M. (Vidar), Stott, D.J. (David J.), Sussmann, J. (Jessika), Thalamuthu, A. (Anbupalam), Toga, A.W. (Arthur W.), Traynor, B. (Bryan), Troncoso, J.C. (Juan), Tsolaki, M. (Magda), Tzourio, C. (Christophe), Uitterlinden, A.G. (André), Hernández, M.C.V. (Maria C. Valdés), Brug, M.P. (Marcel) van der, Lugt, A. (Aad) van der, Wee, N.J. (Nic) van der, Haren, N.E.M. (Neeltje E.) van, Ent, D. (Dennis) van 't, Tol, M.J.D. (Marie-José) van, Vardarajan, B.N. (Badri), Vellas, B. (Bruno), Veltman, D.J. (Dick), Völzke, H. (Henry), Walter, H.J. (Henrik), Wardlaw, J. (Joanna), Wassink, A.M.J. (Annemarie), Weale, M.E. (Michael), Weinberger, D.R. (Daniel R.), Weiner, M.W. (Michael W.), Wen, W. (Wei), Westman, E. (Eric), White, T.J.H. (Tonya), Wong, T.Y. (Tien Y.), Wright, C.B. (Clinton B.), Zielke, R.H. (Ronald H.), Zonderman, A.B., Martin, N.G. (Nicholas), Duijn, C.M. (Cornelia) van, Wright, M.J. (Margaret), Longstreth Jr, W.T., Schumann, G. (Gunter), Grabe, H.J. (Hans Jörgen), Franke, B. (Barbara), Launer, L.J. (Lenore), Medland, S.E. (Sarah), Seshadri, S. (Sudha), Thompson, P.M. (Paul), Ikram, M.K. (Kamran), Hibar, D.P. (Derrek), Adams, H.H.H. (Hieab), Jahanshad, N. (Neda), Chauhan, G. (Ganesh), Stein, J.L., Hofer, E. (Edith), Rentería, M.E. (Miguel), Bis, J.C. (Joshua), Arias-Vásquez, A. (Alejandro), Ikram, M.K. (M. Kamran), Desrivières, S. (Sylvane), Vernooij, M.W. (Meike), Abramovic, L. (Lucija), Alhusaini, S. (Saud), Amin, N. (Najaf), Andersson, M. (Micael), Arfanakis, K. (Konstantinos), Aribisala, B. (Benjamin), Armstrong, N.J. (Nicola J.), Athanasiu, L. (Lavinia), Axelsson, T. (Tomas), Beecham, A.H. (Ashley), Beiser, A. (Alexa), Bernard, M. (Manon), Blanton, S.H. (Susan H.), Bohlken, M.M. (Marc M.), Boks, M.P.M. (Marco), Bralten, L.B.C. (Linda), Brickman, A.M. (Adam M.), Carmichael, O. (Owen), Chakravarty, M.M. (M. Mallar), Chen, Q. (Qiang), Ching, C.R.K. (Christopher), Chouraki, V. (Vincent), Cuellar-Partida, G. (Gabriel), Crivello, F. (Fabrice), Braber, A. (Anouk) den, Doan, N.T. (Nhat Trung), Ehrlich, S.M. (Stefan), Giddaluru, S. (Sudheer), Goldman, A.L. (Aaron L.), Gottesman, R.F. (Rebecca), Grimm, O. (Oliver), Griswold, M.D. (Michael), Guadalupe, T. (Tulio), Gutman, B.A. (Boris A.), Hass, J. (Johanna), Haukvik, U.K. (Unn), Hoehn, D. (David), Holmes, A.J. (Avram), Hoogman, M. (Martine), Janowitz, D. (Deborah), Jia, T. (Tianye), Jørgensen, K.N. (Kjetil N.), Karbalai, N. (Nazanin), Kasperaviciute, D. (Dalia), Kim, S. (Shinseog), Klein, M. (Marieke), Kraemer, B. (Bernd), Lee, P.H. (Phil), Liewald, D.C.M. (David), Lopez, L.M. (Lorna), Luciano, M. (Michelle), MacAre, C. (Christine), Marquand, A.F. (Andre F.), Matarin, M. (Mar), Mather, R., Mattheisen, M. (Manuel), McKay, D.R. (David R.), Milaneschi, Y. (Yuri), Muñoz Maniega, S. (Susana), Nho, K. (Kwangsik), Nugent, A.C. (Allison), Nyquist, P. (Paul), Loohuis, L.M.O. (Loes M. Olde), Oosterlaan, J. (Jaap), Papmeyer, M. (Martina), Pirpamer, L. (Lukas), Pütz, B. (Benno), Ramasamy, A. (Adaikalavan), Richards, J.S. (Jennifer S.), Risacher, S.L. (Shannon), Roiz-Santiañez, R. (Roberto), Rommelse, N. (Nanda), Ropele, S. (Stefan), Rose, E.J. (Emma), Royle, N.A. (Natalie), Rundek, T. (Tatjana), Sämann, P.G. (Philipp), Saremi, A. (Arvin), Satizabal, C.L. (Claudia), Schmaal, L. (Lianne), Schork, N.J. (Nicholas), Shen, L. (Li), Shin, J. (Jean), Shumskaya, E. (Elena), Smith, A.V. (Albert Vernon), Sprooten, R. (Roy), Strike, L.T. (Lachlan), Teumer, A. (Alexander), Tordesillas-Gutierrez, D. (Diana), Toro, R. (Roberto), Trabzuni, D. (Danyah), Trompet, S. (Stella), Vaidya, D. (Dhananjay), van der Grond, J. (Jeroen), Lee, S.J. (Sven) van der, Van Der Meer, D. (Dennis), Van Donkelaar, M.M.J. (Marjolein M. J.), Eijk, K.R. (Kristel) van, Erp, T.G.M. (Theo G.) van, Van Rooij, D. (Daan), Walton, E. (Esther), Westlye, L.T. (Lars), Whelan, C.D. (Christopher), Windham, B.G. (Gwen), Winkler, A.M. (Anderson), Wittfeld, K. (Katharina), Woldehawariat, G. (Girma), Björnsson, A. (Asgeir), Wolfers, T. (Thomas), Yanek, L.R. (Lisa), Yang, J. (Jingyun), Zijdenbos, A.P., Zwiers, M.P. (Marcel), Agartz, I. (Ingrid), Almasy, L. (Laura), Ames, D.J. (David), Amouyel, P. (Philippe), Andreassen, O.A. (Ole), Arepalli, S. (Sampath), Assareh, A.A., Barral, S. (Sandra), Bastin, M.E. (Mark), Becker, D.M. (Diane M.), Becker, J.T. (James), Bennett, D.A. (David A.), Blangero, J. (John), Bokhoven, H. (Hans) van, Boomsma, D.I. (Dorret), Brodaty, H. (Henry), Brouwer, R.M. (Rachel), Brunner, H.G., Buckner, M., Buitelaar, J.K. (Jan), Bulayeva, K. (Kazima), Cahn, W. (Wiepke), Calhoun, V.D. (Vince), Cannon, D.M. (Dara), Cavalleri, G. (Gianpiero), Cheng, C.-Y. (Ching-Yu), Cichon, S. (Sven), Cookson, M.R. (Mark), Corvin, A. (Aiden), Crespo-Facorro, B. (Benedicto), Curran, J.E. (Joanne), Czisch, M. (Michael), Dale, A.M. (Anders), Davies, G.E. (Gareth), Craen, A.J. (Anton) de, Geus, E.J.C. (Eco) de, Jager, P.L. (Philip) de, Zubicaray, G.I. (Greig) de, Deary, I.J. (Ian), Debette, S. (Stéphanie), DeCarli, C. (Charles), Delanty, N., Depondt, C. (Chantal), DeStefano, A.L. (Anita), Dillman, A. (Allissa), Djurovic, S. (Srdjan), Donohoe, D.J. (Dennis), Drevets, D.A. (Douglas), Duggirala, R. (Ravi), Dyer, M.D. (Matthew), Enzinger, C. (Christian), Erk, S., Espeseth, T. (Thomas), Fedko, I.O. (Iryna O.), Fernández, G. (Guillén), Ferrucci, L. (Luigi), Fisher, S.E. (Simon), Fleischman, D. (Debra), Ford, I. (Ian), Fornage, M. (Myriam), Foroud, T. (Tatiana), Fox, P.T. (Peter), Francks, C. (Clyde), Fukunaga, M. (Masaki), Gibbs, J.R. (J. Raphael), Glahn, D.C. (David), Gollub, R.L. (Randy), Göring, H.H.H. (Harald H.), Green, R.C. (Robert C.), Gruber, O. (Oliver), Gudnason, V. (Vilmundur), Guelfi, S. (Sebastian), Håberg, A.K. (Asta K.), Hansell, N.K. (Narelle), Hardy, J. (John), Hartman, C.A. (C.), Hashimoto, R. (Ryota), Hegenscheid, K. (Katrin), Heinz, J. (Judith), Le Hellard, S. (Stephanie), Hernandez, D.G. (Dena), Heslenfeld, D.J. (Dirk), Ho, B.-C. (Beng-Choon), Hoekstra, P.J. (Pieter), Hoffmann, W. (Wolfgang), Hofman, A. (Albert), Holsboer, F. (Florian), Homuth, G. (Georg), Hosten, N. (Norbert), Hottenga, J.J. (Jouke Jan), Huentelman, M.J. (Matthew), Pol, H.H., Ikeda, M. (Masashi), Jack, C.R. (Clifford R.), Jenkinson, S. (Sarah), Johnson, R. (Robert), Jönsson, E.G. (Erik G.), Jukema, J.W., Kahn, R. (René), Kanai, R. (Ryota), Kloszewska, I. (Iwona), Knopman, D.S. (David S.), Kochunov, P. (Peter), Kwok, J.B. (John B.), Lawrie, S. (Stephen), Lemaître, H. (Herve), Liu, X. (Xinmin), Longo, D.L. (Dan L.), Lopez, O.L. (Oscar L.), Lovestone, S. (Simon), Martinez, O. (Oliver), Martinot, J.-L. (Jean-Luc), Mattay, V.S. (Venkata S.), McDonald, C. (Colm), McIntosh, A.M. (Andrew), McMahon, F.J. (Francis J.), McMahon, K.L. (Katie L.), Mecocci, P. (Patrizia), Melle, I. (Ingrid), Meyer-Lindenberg, A. (Andreas), Mohnke, S. (Sebastian), Montgomery, G.W. (Grant W.), Morris, D.W. (Derek W), Mosley, T.H. (Thomas H.), Mühleisen, T.W. (Thomas), Müller-Myhsok, B. (B.), Nalls, M.A. (Michael), Nauck, M. (Matthias), Nichols, T.E. (Thomas), Niessen, W.J. (Wiro), Nöthen, M.M. (Markus), Nyberg, L. (Lars), Ohi, K. (Kazutaka), Olvera, R.L. (Rene), Ophoff, R.A. (Roel), Pandolfo, M. (Massimo), Paus, T. (Tomas), Pausova, Z. (Zdenka), Penninx, B.W.J.H. (Brenda), Pike, G.B. (G. Bruce), Potkin, S.G. (Steven), Psaty, B.M. (Bruce), Reppermund, S., Rietschel, M. (Marcella), Roffman, J.L. (Joshua), Seiferth, N. (Nina), Rotter, J.I. (Jerome I.), Ryten, M. (Mina), Sacco, R.L. (Ralph L.), Sachdev, P.S. (Perminder), Saykin, A.J. (Andrew), Schmidt, R. (Reinhold), Schmidt, H. (Helena), Schofield, C.J. (Christopher), Sigursson, S. (Sigurdur), Simmons, A. (Andrew), Singleton, A. (Andrew), Sisodiya, S.M. (Sanjay), Smith, C. (Colin), Smoller, J.W., Soininen, H. (H.), Steen, V.M. (Vidar), Stott, D.J. (David J.), Sussmann, J. (Jessika), Thalamuthu, A. (Anbupalam), Toga, A.W. (Arthur W.), Traynor, B. (Bryan), Troncoso, J.C. (Juan), Tsolaki, M. (Magda), Tzourio, C. (Christophe), Uitterlinden, A.G. (André), Hernández, M.C.V. (Maria C. Valdés), Brug, M.P. (Marcel) van der, Lugt, A. (Aad) van der, Wee, N.J. (Nic) van der, Haren, N.E.M. (Neeltje E.) van, Ent, D. (Dennis) van 't, Tol, M.J.D. (Marie-José) van, Vardarajan, B.N. (Badri), Vellas, B. (Bruno), Veltman, D.J. (Dick), Völzke, H. (Henry), Walter, H.J. (Henrik), Wardlaw, J. (Joanna), Wassink, A.M.J. (Annemarie), Weale, M.E. (Michael), Weinberger, D.R. (Daniel R.), Weiner, M.W. (Michael W.), Wen, W. (Wei), Westman, E. (Eric), White, T.J.H. (Tonya), Wong, T.Y. (Tien Y.), Wright, C.B. (Clinton B.), Zielke, R.H. (Ronald H.), Zonderman, A.B., Martin, N.G. (Nicholas), Duijn, C.M. (Cornelia) van, Wright, M.J. (Margaret), Longstreth Jr, W.T., Schumann, G. (Gunter), Grabe, H.J. (Hans Jörgen), Franke, B. (Barbara), Launer, L.J. (Lenore), Medland, S.E. (Sarah), Seshadri, S. (Sudha), Thompson, P.M. (Paul), and Ikram, M.K. (Kamran)
Abstract: The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
Published: 2017
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13. Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults:results from a meta-analysis and exploratory meta-regression analysis

Author: Veronese, N. (Nicola), Cereda, E. (Emanuele), Stubbs, B. (Brendon), Solmi, M. (Marco), Luchini, C. (Claudio), Manzato, E. (Enzo), Sergi, G. (Giuseppe), Manu, P. (Peter), Harris, T. (Tamara), Fontana, L. (Luigi), Strandberg, T. (Timo), Amieva, H. (Helene), Dumurgier, J. (Julien), Elbaz, A. (Alexis), Tzourio, C. (Christophe), Eicholzer, M. (Monika), Rohrmann, S. (Sabine), Moretti, C. (Claudio), D’Ascenzo, F. (Fabrizio), Quadri, G. (Giorgio), Polidoro, A. (Alessandro), Lourenço, R. A. (Roberto Alves), Moreira, V. G. (Virgilio Garcia), Sanchis, J. (Juan), Scotti, V. (Valeria), Maggi, S. (Stefania), Correll, C. U. (Christoph U.), Veronese, N. (Nicola), Cereda, E. (Emanuele), Stubbs, B. (Brendon), Solmi, M. (Marco), Luchini, C. (Claudio), Manzato, E. (Enzo), Sergi, G. (Giuseppe), Manu, P. (Peter), Harris, T. (Tamara), Fontana, L. (Luigi), Strandberg, T. (Timo), Amieva, H. (Helene), Dumurgier, J. (Julien), Elbaz, A. (Alexis), Tzourio, C. (Christophe), Eicholzer, M. (Monika), Rohrmann, S. (Sabine), Moretti, C. (Claudio), D’Ascenzo, F. (Fabrizio), Quadri, G. (Giorgio), Polidoro, A. (Alessandro), Lourenço, R. A. (Roberto Alves), Moreira, V. G. (Virgilio Garcia), Sanchis, J. (Juan), Scotti, V. (Valeria), Maggi, S. (Stefania), and Correll, C. U. (Christoph U.)
Abstract: Frailty is common and associated with poorer outcomes in the elderly, but its role as potential cardiovascular disease (CVD) risk factor requires clarification. We thus aimed to meta-analytically evaluate the evidence of frailty and pre-frailty as risk factors for CVD. Two reviewers selected all studies comparing data about CVD prevalence or incidence rates between frail/pre-frail vs. robust. The association between frailty status and CVD in cross-sectional studies was explored by calculating and pooling crude and adjusted odds ratios (ORs) ±95% confidence intervals (CIs); the data from longitudinal studies were pooled using the adjusted hazard ratios (HRs). Eighteen cohorts with a total of 31,343 participants were meta-analyzed. Using estimates from 10 cross-sectional cohorts, both frailty and pre-frailty were associated with higher odds of CVD than robust participants. Longitudinal data were obtained from 6 prospective cohort studies. After a median follow-up of 4.4 years, we identified an increased risk for faster onset of any-type CVD in the frail (HR = 1.70 [95%CI, 1.18–2.45]; I² = 66%) and pre-frail (HR = 1.23 [95%CI, 1.07–1.36]; I² = 67%) vs. robust groups. Similar results were apparent for time to CVD mortality in the frail and pre-frail groups. In conclusion, frailty and pre-frailty constitute addressable and independent risk factors for CVD in older adults.
Published: 2017

14. Worldwide trends in blood pressure from 1975 to 2015:a pooled analysis of 1479 population-based measurement studies with 19.1 million participants

Author: Zhou, B. (Bin), Bentham, J. (James), Di Cesare, M. (Mariachiara), Bixby, H. (Honor), Danaei, G. (Goodarz), Cowan, M. J. (Melanie J.), Paciorek, C. J. (Christopher J.), Singh, G. (Gitanjali), Hajifathalian, K. (Kaveh), Bennett, J. E. (James E.), Taddei, C. (Cristina), Bilano, V. (Ver), Carrillo-Larco, R. M. (Rodrigo M.), Djalalinia, S. (Shirin), Khatibzadeh, S. (Shahab), Lugero, C. (Charles), Peykari, N. (Niloofar), Zhang, W. Z. (Wan Zhu), Lu, Y. (Yuan), Stevens, G. A. (Gretchen A.), Riley, L. M. (Leanne M.), Bovet, P. (Pascal), Elliott, P. (Paul), Gu, D. (Dongfeng), Ikeda, N. (Nayu), Jackson, R. T. (Rod T.), Joffres, M. (Michel), Kengne, A. P. (Andre Pascal), Laatikainen, T. (Tiina), Lam, T. H. (Tai Hing), Laxmaiah, A. (Avula), Liu, J. (Jing), Miranda, J. J. (J. Jaime), Mondo, C. K. (Charles K.), Neuhauser, H. K. (Hannelore K.), Sundstrom, J. (Johan), Smeeth, L. (Liam), Soric, M. (Maroje), Woodward, M. (Mark), Ezzati, M. (Majid), Abarca-Gomez, L. (Leandra), Abdeen, Z. A. (Ziad A.), Rahim, H. A. (Hanan Abdul), Abu-Rmeileh, N. M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Afsana, K. (Kaosar), Aguilar-Salinas, C. A. (Carlos A.), Agyemang, C. (Charles), Ahmadvand, A. (Alireza), Ahrens, W. (Wolfgang), Al Raddadi, R. (Rajaa), Al Woyatan, R. (Rihab), Ali, M. M. (Mohamed M.), Alkerwi, A. (Ala'a), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L. B. (Lars Bo), Anderssen, S. A. (Sigmund A.), Angquist, L. (Lars), Anjana, R. M. (Ranjit Mohan), Ansong, D. (Daniel), Aounallah-Skhiri, H. (Hajer), Araujo, J. (Joana), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Aryal, K. (Krishna), Arveiler, D. (Dominique), Assah, F. K. (Felix K.), Assuncao, M. C. (Maria Cecilia F.), Avdicova, M. (Maria), Azevedo, A. (Ana), Azizi, F. (Fereidoun), Babu, B. V. (Bontha V.), Bahijri, S. (Suhad), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J. R. (Jose R.), Barbagallo, C. M. (Carlo M.), Barcelo, A. (Alberto), Barkat, A. (Amina), Barros, A. J. (Aluisio J. D.), Barros, M. V. (Mauro V.), Bata, I. (Iqbal), Batieha, A. M. (Anwar M.), Baur, L. A. (Louise A.), Beaglehole, R. (Robert), Ben Romdhane, H. (Habiba), Benet, M. (Mikhail), Benson, L. S. (Lowell S.), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S. K. (Santosh K.), Bi, Y. (Yufang), Bikbov, M. (Mukharram), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjokelund, C. (Cecilia), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boeing, H. (Heiner), Boggia, J. G. (Jose G.), Boissonnet, C. P. (Carlos P.), Bongard, V. (Vanina), Braeckman, L. (Lutgart), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L. M. (Lizzy M.), Bruno, G. (Graziella), Bueno-de-Mesquita, H. B. (H. B. (as)), Bugge, A. (Anna), Burns, C. (Con), Bursztyn, M. (Michael), de Leon, A. C. (Antonio Cabrera), Cameron, C. (Christine), Can, G. (Gunay), Candido, A. P. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V. C. (Viviane C.), Carlsson, A. C. (Axel C.), Carvalho, M. J. (Maria J.), Casanueva, F. F. (Felipe F.), Casas, J.-P. (Juan-Pablo), Caserta, C. A. (Carmelo A.), Chamukuttan, S. (Snehalatha), Chan, A. W. (Angelique W.), Chan, Q. (Queenie), Chaturvedi, H. K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Dekkaki, I. C. (Imane Cherkaoui), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F. (Frank), Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Cyrus), Cooper, R. (Rachel), Coppinger, T. C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C. L. (Cora L.), Crujeiras, A. B. (Ana B.), Cruz, J. J. (Juan J.), D'Arrigo, G. (Graziella), d'Orsi, E. (Eleonora), Dallongeville, J. (Jean), Damasceno, A. (Albertino), Dankner, R. (Rachel), Dantoft, T. M. (Thomas M.), Dauchet, L. (Luc), De Backer, G. (Guy), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Dehghan, A. (Abbas), Delisle, H. (Helene), Deschamps, V. (Valerie), Dhana, K. (Klodian), Di Castelnuovo, A. F. (Augusto F.), Dias-da-Costa, J. S. (Juvenal Soares), Diaz, A. (Alejandro), Dickerson, T. T. (Ty T.), Do, H. T. (Ha T. P.), Dobson, A. J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S. P. (Silvana P.), Doering, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Dulskiene, V. (Virginija), Dzakula, A. (Aleksandar), Dzerve, V. (Vilnis), Dziankowska-Zaborszczyk, E. (Elzbieta), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Ellert, U. (Ute), Elosua, R. (Roberto), Erasmus, R. T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), Escobedo-de la Pena, J. (Jorge), Evans, A. (Alun), Faeh, D. (David), Fall, C. H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F. J. (Francisco J.), Ferguson, T. S. (Trevor S.), Fernandez-Berges, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J. D. (Joseph D.), Fischer, K. (Krista), Foeger, B. (Bernhard), Foo, L. H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fortmann, S. P. (Stephen P.), Fouad, H. M. (Heba M.), Francis, D. K. (Damian K.), Franco, M. d. (Maria do Carmo), Franco, O. H. (Oscar H.), Frontera, G. (Guillermo), Fuchs, F. D. (Flavio D.), Fuchs, S. C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gareta, D. (Dickman), Garnett, S. P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Gavrila, D. (Diana), Geleijnse, J. M. (Johanna M.), Ghasemian, A. (Anoosheh), Ghimire, A. (Anup), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Goldsmith, R. A. (Rebecca A.), Goncalves, H. (Helen), Gonzalez Gross, M. (Marcela), Gonzalez Rivas, J. P. (Juan P.), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dusan), Grajda, A. (Aneta), Gregor, R. D. (Ronald D.), Grodzicki, T. (Tomasz), Grontved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Guan, O. P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A. L. (Andre L.), Gulliford, M. C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Gunter, M. (Marc), Gupta, P. C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Hadaegh, F. (Farzad), Halkjaer, J. (Jytte), Hambleton, I. R. (Ian R.), Hardy, R. (Rebecca), Harikumar, R. (Rachakulla), Hata, J. (Jun), Hayes, A. J. (Alison J.), He, J. (Jiang), Hendriks, M. E. (Marleen Elisabeth), Henriques, A. (Ana), Hernandez Cadena, L. (Leticia), . (), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hihtaniemi, I. T. (Ilpo Tapani), Ho, S. Y. (Sai Yin), Ho, S. C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Dinc, G. H. (Gonul Horasan), Hormiga, C. M. (Claudia M.), Horta, B. L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T. T. (Thein Thein), Htet, A. S. (Aung Soe), Hu, Y. (Yonghua), Maria Huerta, J. (Jose), Husseini, A. S. (Abdullatif S.), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A. G. (Anna G.), Ibrahim, M. M. (M. Mohsen), Ikram, M. A. (M. Arfan), Irazola, V. E. (Vilma E.), Islam, M. (Muhammad), Ivkovic, V. (Vanja), Iwasaki, M. (Masanori), Jacobs, J. M. (Jeremy M.), Jafar, T. (Tazeen), Jamrozik, K. (Konrad), Janszky, I. (Imre), Jasienska, G. (Grazyna), Jelakovic, B. (Bojan), Jiang, C. Q. (Chao Qiang), Johansson, M. (Mattias), Jonas, J. B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Juresa, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kamaruddin, N. A. (Nor Azmi), Kasaeian, A. (Amir), Katz, J. (Joanne), Kauhanen, J. (Jussi), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Kazakbaeva, G. (Gyulli), Keil, U. (Ulrich), Boker, L. K. (Lital Keinan), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Kemper, H. C. (Han C. G.), Kersting, M. (Mathilde), Key, T. (Timothy), Khader, Y. S. (Yousef Saleh), Khalili, D. (Davood), Khang, Y.-H. (Young-Ho), Khaw, K.-T. (Kay-Tee), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Klumbiene, J. (Jurate), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kristensen, P. L. (Peter Lund), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H. S. (Herculina S.), Kubinova, R. (Ruzena), Kuciene, R. (Renata), Kuh, D. (Diana), Kujala, U. M. (Urho M.), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Kumar, R. K. (R. Krishna), Kurjata, P. (Pawel), Kusuma, Y. S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Kyobutungi, C. (Catherine), Lachat, C. (Carl), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Laugsand, L. E. (Lars E.), Le, T. D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehtimaki, T. (Terho), Lekhraj, R. (Rampal), Leon-Munoz, L. M. (Luz M.), Levitt, N. S. (Naomi S.), Li, Y. (Yanping), Lilly, C. L. (Christa L.), Lim, W.-Y. (Wei-Yen), Fernanda Lima-Costa, M. (M.), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Lorbeer, R. (Roberto), Lotufo, P. A. (Paulo A.), Eugenio Lozano, J. (Jose), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Ma, J. (Jun), Machado-Coelho, G. L. (George L. L.), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D. J. (Dianna J.), Majer, M. (Marjeta), Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K. M. (Kodavanti Mallikharjuna), Malyutina, S. (Sofia), Manios, Y. (Yannis), Mann, J. I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martorell, R. (Reynaldo), Mathiesen, E. B. (Ellisiv B.), Matijasevich, A. (Alicia), Matsha, T. E. (Tandi E.), Mbanya, J. C. (Jean Claude N.), Posso, A. J. (Anselmo J. Mc Donald), McFarlane, S. R. (Shelly R.), McGarvey, S. T. (Stephen T.), McLachlan, S. (Stela), McLean, R. M. (Rachael M.), McNulty, B. A. (Breige A.), Khir, A. S. (Amir Sharifuddin Md), Mediene-Benchekor, S. (Sounnia), Medzioniene, J. (Jurate), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A. M. (Ana Maria B.), Menon, G. R. (Geetha R.), Meshram, I. I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Mikkel, K. (Kairit), Miller, J. C. (Jody C.), Francisco Miquel, J. (Juan), Jaime Miranda, J. (J.), Misigoj-Durakovic, M. (Marjeta), Mohamed, M. K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M. F. (Muhammad Fadhli Mohd), Moller, N. C. (Niels C.), Molnar, D. (Denes), Momenan, A. (Amirabbas), Monyeki, K. D. (Kotsedi Daniel K.), Moreira, L. B. (Leila B.), Morejon, A. (Alain), Moreno, L. A. (Luis A.), Morgan, K. (Karen), Moschonis, G. (George), Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M. E. (Mohammad Esmaeel), Motta, J. (Jorge), Muiesan, M. L. (Maria L.), Mueller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Musil, V. (Vera), Nagel, G. (Gabriele), Naidu, B. M. (Balkish M.), Nakamura, H. (Harunobu), Namsna, J. (Jana), Nang, E. E. (Ei Ei K.), Nangia, V. B. (Vinay B.), Narake, S. (Sameer), Maria Navarrete-Munoz, E. (Eva), Ndiaye, N. C. (Ndeye Coumba), Neal, W. A. (William A.), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N. D. (Nguyen D.), Nieto-Martinez, R. E. (Ramfis E.), Niiranen, T. J. (Teemu J.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Noboa, O. A. (Oscar A.), Noorbala, A. A. (Ahmad Ali), Norat, T. (Teresa), Noto, D. (Davide), Al Nsour, M. (Mohannad), O'Reilly, D. (Dermot), Oh, K. (Kyungwon), Olinto, M. T. (Maria Teresa A.), Oliveira, I. O. (Isabel O.), Omar, M. A. (Mohd Azahadi), Onat, A. (Altan), Ordunez, P. (Pedro), Osmond, C. (Clive), Ostojic, S. M. (Sergej M.), Otero, J. A. (Johanna A.), Overvad, K. (Kim), Owusu-Dabo, E. (Ellis), Paccaud, F. M. (Fred Michel), Padez, C. (Cristina), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palli, D. (Domenico), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Papandreou, D. (Dimitrios), Parnell, W. R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pecin, I. (Ivan), Pednekar, M. S. (Mangesh S.), Peer, N. (Nasheeta), Peeters, P. H. (Petra H.), Peixoto, S. V. (Sergio Viana), Pelletier, C. (Catherine), Peltonen, M. (Markku), Pereira, A. C. (Alexandre C.), Marina Perez, R. (Rosa), Peters, A. (Annette), Petkeviciene, J. (Janina), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, L. (Lorenza), Pitakaka, F. (Freda), Plans-Rubio, P. (Pedro), Polakowska, M. (Maria), Polasek, O. (Ozren), Porta, M. (Miquel), Portegies, M. L. (Marileen L. P.), Pourshams, A. (Akram), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J. F. (Jacqueline F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R. F. (Radwan F.), Qorbani, M. (Mostafa), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M. (Mahfuzar), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S. R. (Sudha Ramachandra), Ramos, E. (Elisabete), Rampal, S. (Sanjay), Rangel Reina, D. A. (Daniel A.), Rasmussen, F. (Finn), Redon, J. (Josep), Reganit, P. F. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), de Wit, T. F. (Tobias F. Rinke), Ritti-Dias, R. M. (Raphael M.), Robinson, S. M. (Sian M.), Robitaille, C. (Cynthia), Rodriguez-Artalejo, F. (Fernando), Rodriguez-Villamizar, L. A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rosengren, A. (Annika), Rubinstein, A. (Adolfo), Rui, O. (Ornelas), Sandra Ruiz-Betancourt, B. (Blanca), Russo Horimoto, A. R. (Andrea R. V.), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H. S. (Harshpal S.), Saidi, O. (Olfa), Sakarya, S. (Sibel), Salanave, B. (Benoit), Salazar Martinez, E. (Eduardo), Salmeron, D. (Diego), Salomaa, V. (Veikko), Salonen, J. T. (Jukka T.), Salvetti, M. (Massimo), Sanchez-Abanto, J. (Jose), Sans, S. (Susana), Santos, D. (Diana), Santos, I. S. (Ina S.), dos Santos, R. N. (Renata Nunes), Santos, R. (Rute), Saramies, J. L. (Jouko L.), Sardinha, L. B. (Luis B.), Margolis, G. S. (Giselle Sarganas), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S. C. (Savvas C.), Scazufca, M. (Marcia), Schargrodsky, H. (Herman), Schneider, I. J. (Ione J.), Schultsz, C. (Constance), Schutte, A. E. (Aletta E.), Sen, A. (Abhijit), Senbanjo, I. O. (Idowu O.), Sepanlou, S. G. (Sadaf G.), Sharma, S. K. (Sanjib K.), Shaw, J. E. (Jonathan E.), Shibuya, K. (Kenji), Shin, D. W. (Dong Wook), Shin, Y. (Youchan), Siantar, R. (Rosalynn), Sibai, A. M. (Abla M.), Santos Silva, D. A. (Diego Augusto), Simon, M. (Mary), Simons, J. (Judith), Simons, L. A. (Leon A.), Sjotrom, M. (Michael), Skovbjerg, S. (Sine), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smith, M. C. (Margaret C.), Snijder, M. B. (Marieke B.), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugene), Soderberg, S. (Stefan), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Song, Y. (Yi), Sorensen, T. I. (Thorkild I. A.), Jerome, C. S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J. A. (Jan A.), Starc, G. (Gregor), Stathopoulou, M. G. (Maria G.), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A. D. (Aryeh D.), Stergiou, G. S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stoeckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M. W. (Maria Wany), Sun, C.-A. (Chien-An), Sung, Y.-T. (Yn-Tz), Suriyawongpaisal, P. (Paibul), Sy, R. G. (Rody G.), Tai, E. S. (E. Shyong), Tammesoo, M.-L. (Mari-Liis), Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M. R. (Mohammed Rasoul), Tarqui-Mamani, C. B. (Carolina B.), Taylor, A. (Anne), Theobald, H. (Holger), Thijs, L. (Lutgarde), Thuesen, B. H. (Betina H.), Tjonneland, A. (Anne), Tolonen, H. K. (Hanna K.), Topbas, M. (Murat), Topor-Madry, R. (Roman), Jose Tormo, M. (Maria), Torrent, M. (Maties), Traissac, P. (Pierre), Trichopoulos, D. (Dimitrios), Trichopoulou, A. (Antonia), Trinh, O. T. (Oanh T. H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M. K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Turley, M. L. (Maria L.), Tynelius, P. (Per), Tzourio, C. (Christophe), Ueda, P. (Peter), Ugel, E. (Eunice), Ulmer, H. (Hanno), Uusitalo, H. M. (Hannu M. T.), Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), van der Schouw, Y. T. (Yvonne T.), Van Herck, K. (Koen), van Rossem, L. (Lenie), van Valkengoed, I. G. (Irene G. M.), Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Verschuren, W. M. (W. M. Monique), Verstraeten, R. (Roosmarijn), Victora, C. G. (Cesar G.), Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J. K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Vrdoljak, A. (Ana), Vrijheid, M. (Martine), Wade, A. N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W. N. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. X. (Ya Xing), Wannamethee, S. G. (S. Goya), Wareham, N. (Nicholas), Wederkopp, N. (Niels), Weerasekera, D. (Deepa), Whincup, P. H. (Peter H.), Widhalm, K. (Kurt), Widyahening, I. S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A. H. (Alet H.), Wilks, R. J. (Rainford J.), Willeit, P. (Peter), Williams, E. A. (Emmanuel A.), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong, T. Y. (Tien Yin), Wong-McClure, R. A. (Roy A.), Woo, J. (Jean), Wu, A. G. (Aleksander Giwercman), Wu, F. C. (Frederick C.), Wu, S. L. (Shou Ling), Xu, H. (Haiquan), Yan, W. (Weili), Yang, X. (Xiaoguang), Ye, X. (Xingwang), Yiallouros, P. K. (Panayiotis K.), Yoshihara, A. (Akihiro), Younger-Coleman, N. O. (Novie O.), Yusoff, A. F. (Ahmad F.), Zambon, S. (Sabina), Zdrojewski, T. (Tomasz), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingffeng), Zhu, D. (Dan), Zimmermann, E. (Esther), Zuniga Cisneros, J. (Julio), Zhou, B. (Bin), Bentham, J. (James), Di Cesare, M. (Mariachiara), Bixby, H. (Honor), Danaei, G. (Goodarz), Cowan, M. J. (Melanie J.), Paciorek, C. J. (Christopher J.), Singh, G. (Gitanjali), Hajifathalian, K. (Kaveh), Bennett, J. E. (James E.), Taddei, C. (Cristina), Bilano, V. (Ver), Carrillo-Larco, R. M. (Rodrigo M.), Djalalinia, S. (Shirin), Khatibzadeh, S. (Shahab), Lugero, C. (Charles), Peykari, N. (Niloofar), Zhang, W. Z. (Wan Zhu), Lu, Y. (Yuan), Stevens, G. A. (Gretchen A.), Riley, L. M. (Leanne M.), Bovet, P. (Pascal), Elliott, P. (Paul), Gu, D. (Dongfeng), Ikeda, N. (Nayu), Jackson, R. T. (Rod T.), Joffres, M. (Michel), Kengne, A. P. (Andre Pascal), Laatikainen, T. (Tiina), Lam, T. H. (Tai Hing), Laxmaiah, A. (Avula), Liu, J. (Jing), Miranda, J. J. (J. Jaime), Mondo, C. K. (Charles K.), Neuhauser, H. K. (Hannelore K.), Sundstrom, J. (Johan), Smeeth, L. (Liam), Soric, M. (Maroje), Woodward, M. (Mark), Ezzati, M. (Majid), Abarca-Gomez, L. (Leandra), Abdeen, Z. A. (Ziad A.), Rahim, H. A. (Hanan Abdul), Abu-Rmeileh, N. M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Afsana, K. (Kaosar), Aguilar-Salinas, C. A. (Carlos A.), Agyemang, C. (Charles), Ahmadvand, A. (Alireza), Ahrens, W. (Wolfgang), Al Raddadi, R. (Rajaa), Al Woyatan, R. (Rihab), Ali, M. M. (Mohamed M.), Alkerwi, A. (Ala'a), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L. B. (Lars Bo), Anderssen, S. A. (Sigmund A.), Angquist, L. (Lars), Anjana, R. M. (Ranjit Mohan), Ansong, D. (Daniel), Aounallah-Skhiri, H. (Hajer), Araujo, J. (Joana), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Aryal, K. (Krishna), Arveiler, D. (Dominique), Assah, F. K. (Felix K.), Assuncao, M. C. (Maria Cecilia F.), Avdicova, M. (Maria), Azevedo, A. (Ana), Azizi, F. (Fereidoun), Babu, B. V. (Bontha V.), Bahijri, S. (Suhad), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J. R. (Jose R.), Barbagallo, C. M. (Carlo M.), Barcelo, A. (Alberto), Barkat, A. (Amina), Barros, A. J. (Aluisio J. D.), Barros, M. V. (Mauro V.), Bata, I. (Iqbal), Batieha, A. M. (Anwar M.), Baur, L. A. (Louise A.), Beaglehole, R. (Robert), Ben Romdhane, H. (Habiba), Benet, M. (Mikhail), Benson, L. S. (Lowell S.), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S. K. (Santosh K.), Bi, Y. (Yufang), Bikbov, M. (Mukharram), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjokelund, C. (Cecilia), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boeing, H. (Heiner), Boggia, J. G. (Jose G.), Boissonnet, C. P. (Carlos P.), Bongard, V. (Vanina), Braeckman, L. (Lutgart), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L. M. (Lizzy M.), Bruno, G. (Graziella), Bueno-de-Mesquita, H. B. (H. B. (as)), Bugge, A. (Anna), Burns, C. (Con), Bursztyn, M. (Michael), de Leon, A. C. (Antonio Cabrera), Cameron, C. (Christine), Can, G. (Gunay), Candido, A. P. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V. C. (Viviane C.), Carlsson, A. C. (Axel C.), Carvalho, M. J. (Maria J.), Casanueva, F. F. (Felipe F.), Casas, J.-P. (Juan-Pablo), Caserta, C. A. (Carmelo A.), Chamukuttan, S. (Snehalatha), Chan, A. W. (Angelique W.), Chan, Q. (Queenie), Chaturvedi, H. K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Dekkaki, I. C. (Imane Cherkaoui), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F. (Frank), Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Cyrus), Cooper, R. (Rachel), Coppinger, T. C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C. L. (Cora L.), Crujeiras, A. B. (Ana B.), Cruz, J. J. (Juan J.), D'Arrigo, G. (Graziella), d'Orsi, E. (Eleonora), Dallongeville, J. (Jean), Damasceno, A. (Albertino), Dankner, R. (Rachel), Dantoft, T. M. (Thomas M.), Dauchet, L. (Luc), De Backer, G. (Guy), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Dehghan, A. (Abbas), Delisle, H. (Helene), Deschamps, V. (Valerie), Dhana, K. (Klodian), Di Castelnuovo, A. F. (Augusto F.), Dias-da-Costa, J. S. (Juvenal Soares), Diaz, A. (Alejandro), Dickerson, T. T. (Ty T.), Do, H. T. (Ha T. P.), Dobson, A. J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S. P. (Silvana P.), Doering, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Dulskiene, V. (Virginija), Dzakula, A. (Aleksandar), Dzerve, V. (Vilnis), Dziankowska-Zaborszczyk, E. (Elzbieta), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Ellert, U. (Ute), Elosua, R. (Roberto), Erasmus, R. T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), Escobedo-de la Pena, J. (Jorge), Evans, A. (Alun), Faeh, D. (David), Fall, C. H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F. J. (Francisco J.), Ferguson, T. S. (Trevor S.), Fernandez-Berges, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J. D. (Joseph D.), Fischer, K. (Krista), Foeger, B. (Bernhard), Foo, L. H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fortmann, S. P. (Stephen P.), Fouad, H. M. (Heba M.), Francis, D. K. (Damian K.), Franco, M. d. (Maria do Carmo), Franco, O. H. (Oscar H.), Frontera, G. (Guillermo), Fuchs, F. D. (Flavio D.), Fuchs, S. C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gareta, D. (Dickman), Garnett, S. P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Gavrila, D. (Diana), Geleijnse, J. M. (Johanna M.), Ghasemian, A. (Anoosheh), Ghimire, A. (Anup), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Goldsmith, R. A. (Rebecca A.), Goncalves, H. (Helen), Gonzalez Gross, M. (Marcela), Gonzalez Rivas, J. P. (Juan P.), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dusan), Grajda, A. (Aneta), Gregor, R. D. (Ronald D.), Grodzicki, T. (Tomasz), Grontved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Guan, O. P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A. L. (Andre L.), Gulliford, M. C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Gunter, M. (Marc), Gupta, P. C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Hadaegh, F. (Farzad), Halkjaer, J. (Jytte), Hambleton, I. R. (Ian R.), Hardy, R. (Rebecca), Harikumar, R. (Rachakulla), Hata, J. (Jun), Hayes, A. J. (Alison J.), He, J. (Jiang), Hendriks, M. E. (Marleen Elisabeth), Henriques, A. (Ana), Hernandez Cadena, L. (Leticia), . (), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hihtaniemi, I. T. (Ilpo Tapani), Ho, S. Y. (Sai Yin), Ho, S. C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Dinc, G. H. (Gonul Horasan), Hormiga, C. M. (Claudia M.), Horta, B. L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T. T. (Thein Thein), Htet, A. S. (Aung Soe), Hu, Y. (Yonghua), Maria Huerta, J. (Jose), Husseini, A. S. (Abdullatif S.), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A. G. (Anna G.), Ibrahim, M. M. (M. Mohsen), Ikram, M. A. (M. Arfan), Irazola, V. E. (Vilma E.), Islam, M. (Muhammad), Ivkovic, V. (Vanja), Iwasaki, M. (Masanori), Jacobs, J. M. (Jeremy M.), Jafar, T. (Tazeen), Jamrozik, K. (Konrad), Janszky, I. (Imre), Jasienska, G. (Grazyna), Jelakovic, B. (Bojan), Jiang, C. Q. (Chao Qiang), Johansson, M. (Mattias), Jonas, J. B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Juresa, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kamaruddin, N. A. (Nor Azmi), Kasaeian, A. (Amir), Katz, J. (Joanne), Kauhanen, J. (Jussi), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Kazakbaeva, G. (Gyulli), Keil, U. (Ulrich), Boker, L. K. (Lital Keinan), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Kemper, H. C. (Han C. G.), Kersting, M. (Mathilde), Key, T. (Timothy), Khader, Y. S. (Yousef Saleh), Khalili, D. (Davood), Khang, Y.-H. (Young-Ho), Khaw, K.-T. (Kay-Tee), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Klumbiene, J. (Jurate), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kristensen, P. L. (Peter Lund), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H. S. (Herculina S.), Kubinova, R. (Ruzena), Kuciene, R. (Renata), Kuh, D. (Diana), Kujala, U. M. (Urho M.), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Kumar, R. K. (R. Krishna), Kurjata, P. (Pawel), Kusuma, Y. S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Kyobutungi, C. (Catherine), Lachat, C. (Carl), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Laugsand, L. E. (Lars E.), Le, T. D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehtimaki, T. (Terho), Lekhraj, R. (Rampal), Leon-Munoz, L. M. (Luz M.), Levitt, N. S. (Naomi S.), Li, Y. (Yanping), Lilly, C. L. (Christa L.), Lim, W.-Y. (Wei-Yen), Fernanda Lima-Costa, M. (M.), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Lorbeer, R. (Roberto), Lotufo, P. A. (Paulo A.), Eugenio Lozano, J. (Jose), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Ma, J. (Jun), Machado-Coelho, G. L. (George L. L.), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D. J. (Dianna J.), Majer, M. (Marjeta), Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K. M. (Kodavanti Mallikharjuna), Malyutina, S. (Sofia), Manios, Y. (Yannis), Mann, J. I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martorell, R. (Reynaldo), Mathiesen, E. B. (Ellisiv B.), Matijasevich, A. (Alicia), Matsha, T. E. (Tandi E.), Mbanya, J. C. (Jean Claude N.), Posso, A. J. (Anselmo J. Mc Donald), McFarlane, S. R. (Shelly R.), McGarvey, S. T. (Stephen T.), McLachlan, S. (Stela), McLean, R. M. (Rachael M.), McNulty, B. A. (Breige A.), Khir, A. S. (Amir Sharifuddin Md), Mediene-Benchekor, S. (Sounnia), Medzioniene, J. (Jurate), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A. M. (Ana Maria B.), Menon, G. R. (Geetha R.), Meshram, I. I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Mikkel, K. (Kairit), Miller, J. C. (Jody C.), Francisco Miquel, J. (Juan), Jaime Miranda, J. (J.), Misigoj-Durakovic, M. (Marjeta), Mohamed, M. K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M. F. (Muhammad Fadhli Mohd), Moller, N. C. (Niels C.), Molnar, D. (Denes), Momenan, A. (Amirabbas), Monyeki, K. D. (Kotsedi Daniel K.), Moreira, L. B. (Leila B.), Morejon, A. (Alain), Moreno, L. A. (Luis A.), Morgan, K. (Karen), Moschonis, G. (George), Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M. E. (Mohammad Esmaeel), Motta, J. (Jorge), Muiesan, M. L. (Maria L.), Mueller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Musil, V. (Vera), Nagel, G. (Gabriele), Naidu, B. M. (Balkish M.), Nakamura, H. (Harunobu), Namsna, J. (Jana), Nang, E. E. (Ei Ei K.), Nangia, V. B. (Vinay B.), Narake, S. (Sameer), Maria Navarrete-Munoz, E. (Eva), Ndiaye, N. C. (Ndeye Coumba), Neal, W. A. (William A.), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N. D. (Nguyen D.), Nieto-Martinez, R. E. (Ramfis E.), Niiranen, T. J. (Teemu J.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Noboa, O. A. (Oscar A.), Noorbala, A. A. (Ahmad Ali), Norat, T. (Teresa), Noto, D. (Davide), Al Nsour, M. (Mohannad), O'Reilly, D. (Dermot), Oh, K. (Kyungwon), Olinto, M. T. (Maria Teresa A.), Oliveira, I. O. (Isabel O.), Omar, M. A. (Mohd Azahadi), Onat, A. (Altan), Ordunez, P. (Pedro), Osmond, C. (Clive), Ostojic, S. M. (Sergej M.), Otero, J. A. (Johanna A.), Overvad, K. (Kim), Owusu-Dabo, E. (Ellis), Paccaud, F. M. (Fred Michel), Padez, C. (Cristina), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palli, D. (Domenico), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Papandreou, D. (Dimitrios), Parnell, W. R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pecin, I. (Ivan), Pednekar, M. S. (Mangesh S.), Peer, N. (Nasheeta), Peeters, P. H. (Petra H.), Peixoto, S. V. (Sergio Viana), Pelletier, C. (Catherine), Peltonen, M. (Markku), Pereira, A. C. (Alexandre C.), Marina Perez, R. (Rosa), Peters, A. (Annette), Petkeviciene, J. (Janina), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, L. (Lorenza), Pitakaka, F. (Freda), Plans-Rubio, P. (Pedro), Polakowska, M. (Maria), Polasek, O. (Ozren), Porta, M. (Miquel), Portegies, M. L. (Marileen L. P.), Pourshams, A. (Akram), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J. F. (Jacqueline F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R. F. (Radwan F.), Qorbani, M. (Mostafa), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M. (Mahfuzar), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S. R. (Sudha Ramachandra), Ramos, E. (Elisabete), Rampal, S. (Sanjay), Rangel Reina, D. A. (Daniel A.), Rasmussen, F. (Finn), Redon, J. (Josep), Reganit, P. F. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), de Wit, T. F. (Tobias F. Rinke), Ritti-Dias, R. M. (Raphael M.), Robinson, S. M. (Sian M.), Robitaille, C. (Cynthia), Rodriguez-Artalejo, F. (Fernando), Rodriguez-Villamizar, L. A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rosengren, A. (Annika), Rubinstein, A. (Adolfo), Rui, O. (Ornelas), Sandra Ruiz-Betancourt, B. (Blanca), Russo Horimoto, A. R. (Andrea R. V.), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H. S. (Harshpal S.), Saidi, O. (Olfa), Sakarya, S. (Sibel), Salanave, B. (Benoit), Salazar Martinez, E. (Eduardo), Salmeron, D. (Diego), Salomaa, V. (Veikko), Salonen, J. T. (Jukka T.), Salvetti, M. (Massimo), Sanchez-Abanto, J. (Jose), Sans, S. (Susana), Santos, D. (Diana), Santos, I. S. (Ina S.), dos Santos, R. N. (Renata Nunes), Santos, R. (Rute), Saramies, J. L. (Jouko L.), Sardinha, L. B. (Luis B.), Margolis, G. S. (Giselle Sarganas), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S. C. (Savvas C.), Scazufca, M. (Marcia), Schargrodsky, H. (Herman), Schneider, I. J. (Ione J.), Schultsz, C. (Constance), Schutte, A. E. (Aletta E.), Sen, A. (Abhijit), Senbanjo, I. O. (Idowu O.), Sepanlou, S. G. (Sadaf G.), Sharma, S. K. (Sanjib K.), Shaw, J. E. (Jonathan E.), Shibuya, K. (Kenji), Shin, D. W. (Dong Wook), Shin, Y. (Youchan), Siantar, R. (Rosalynn), Sibai, A. M. (Abla M.), Santos Silva, D. A. (Diego Augusto), Simon, M. (Mary), Simons, J. (Judith), Simons, L. A. (Leon A.), Sjotrom, M. (Michael), Skovbjerg, S. (Sine), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smith, M. C. (Margaret C.), Snijder, M. B. (Marieke B.), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugene), Soderberg, S. (Stefan), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Song, Y. (Yi), Sorensen, T. I. (Thorkild I. A.), Jerome, C. S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J. A. (Jan A.), Starc, G. (Gregor), Stathopoulou, M. G. (Maria G.), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A. D. (Aryeh D.), Stergiou, G. S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stoeckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M. W. (Maria Wany), Sun, C.-A. (Chien-An), Sung, Y.-T. (Yn-Tz), Suriyawongpaisal, P. (Paibul), Sy, R. G. (Rody G.), Tai, E. S. (E. Shyong), Tammesoo, M.-L. (Mari-Liis), Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M. R. (Mohammed Rasoul), Tarqui-Mamani, C. B. (Carolina B.), Taylor, A. (Anne), Theobald, H. (Holger), Thijs, L. (Lutgarde), Thuesen, B. H. (Betina H.), Tjonneland, A. (Anne), Tolonen, H. K. (Hanna K.), Topbas, M. (Murat), Topor-Madry, R. (Roman), Jose Tormo, M. (Maria), Torrent, M. (Maties), Traissac, P. (Pierre), Trichopoulos, D. (Dimitrios), Trichopoulou, A. (Antonia), Trinh, O. T. (Oanh T. H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M. K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Turley, M. L. (Maria L.), Tynelius, P. (Per), Tzourio, C. (Christophe), Ueda, P. (Peter), Ugel, E. (Eunice), Ulmer, H. (Hanno), Uusitalo, H. M. (Hannu M. T.), Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), van der Schouw, Y. T. (Yvonne T.), Van Herck, K. (Koen), van Rossem, L. (Lenie), van Valkengoed, I. G. (Irene G. M.), Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Verschuren, W. M. (W. M. Monique), Verstraeten, R. (Roosmarijn), Victora, C. G. (Cesar G.), Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J. K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Vrdoljak, A. (Ana), Vrijheid, M. (Martine), Wade, A. N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W. N. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. X. (Ya Xing), Wannamethee, S. G. (S. Goya), Wareham, N. (Nicholas), Wederkopp, N. (Niels), Weerasekera, D. (Deepa), Whincup, P. H. (Peter H.), Widhalm, K. (Kurt), Widyahening, I. S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A. H. (Alet H.), Wilks, R. J. (Rainford J.), Willeit, P. (Peter), Williams, E. A. (Emmanuel A.), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong, T. Y. (Tien Yin), Wong-McClure, R. A. (Roy A.), Woo, J. (Jean), Wu, A. G. (Aleksander Giwercman), Wu, F. C. (Frederick C.), Wu, S. L. (Shou Ling), Xu, H. (Haiquan), Yan, W. (Weili), Yang, X. (Xiaoguang), Ye, X. (Xingwang), Yiallouros, P. K. (Panayiotis K.), Yoshihara, A. (Akihiro), Younger-Coleman, N. O. (Novie O.), Yusoff, A. F. (Ahmad F.), Zambon, S. (Sabina), Zdrojewski, T. (Tomasz), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingffeng), Zhu, D. (Dan), Zimmermann, E. (Esther), and Zuniga Cisneros, J. (Julio)
Abstract: Background: Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods: For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of raised blood pressure for 200 countries. We calculated the contributions of changes in prevalence versus population growth and ageing to the increase in the number of adults with raised blood pressure. Findings: We pooled 1479 studies that had measured the blood pressures of 19.1 million adults. Global age-standardised mean systolic blood pressure in 2015 was 127.0 mm Hg (95% credible interval 125.7–128.3) in men and 122.3 mm Hg (121.0–123.6) in women; age-standardised mean diastolic blood pressure was 78.7 mm Hg (77.9–79.5) for men and 76.7 mm Hg (75.9–77.6) for women. Global age-standardised prevalence of raised blood pressure was 24.1% (21.4–27.1) in men and 20.1% (17.8–22.5) in women in 2015. Mean systolic and mean diastolic blood pressure decreased substantially from 1975 to 2015 in high-income western and Asia Pacific countries, moving these countries from having some of the highest worldwide blood pressure in 1975 to the lowest in 2015. Mean blood pressure also decreased in women in central and eastern Europe, Latin America and the Caribbean, and, more recently, central Asia, Middle East, and north Africa, but the estimated trends in these super-regions had larger uncertainty than in high-income super-regions. By contrast, mean blood pressure might have increased in
Published: 2017

15. Worldwide trends in diabetes since 1980: A pooled analysis of 751 population-based studies with 4.4 million participants

Author: Zhou, B. (Bin), Lu, Y. (Yuan), Hajifathalian, K. (Kaveh), Bentham, J. (James), Di Cesare, M. (Mariachiara), Danaei, G. (Goodarz), Bixby, H. (Honor), Cowan, M.J. (Melanie J.), Ali, M.K. (Mohammed), Taddei, C. (Cristina), Lo, W.-C. (Wei-Cheng), Reis-Santos, B. (Barbara), Stevens, G.A. (Gretchen A.), Riley, L.M. (Leanne M.), Miranda, J.J. (J. Jaime), Bjerregaard, P. (Peter), Rivera, J.A. (Juan A.), Fouad, H.M. (Heba M.), Ma, G. (Guansheng), Mbanya, J.C.N. (Jean Claude N.), McGarvey, S.T. (Stephen T.), Mohan, V. (Viswanathan), Onat, A. (Altan), Pilav, A. (Aida), Ramachandran, A. (Ambady), Ben Romdhane, H. (Habiba), Paciorek, C.J. (Christopher J.), Bennett, J.E. (James E.), Ezzati, M. (Majid), Abdeen, Z.A. (Ziad A.), Kadir, K.A. (Khalid Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Aguilar-Salinas, C.A. (Carlos), Agyemang, C.O. (Charles), Ahmadvand, A. (Alireza), Al-Othman, A.R. (Amani Rashed), Alkerwi, A. (Ala'a), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Bo Andersen, L. (Lars), Anderssen, S.A. (Sigmund A.), Anjana, R.M. (Ranjit Mohan), Aounallah-Skhiri, H. (Hajer), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Arveiler, D. (Dominique), Assah, F.K. (Felix K.), Avdicová, M. (Mária), Azizi, J. (Joshan), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Batieha, A.M. (Anwar M.), Baur, L.A. (Louise A.), Benet, M. (Mikhail), Bernabe-Ortiz, A. (Antonio), Bharadwaj, S. (Sumit), Bhargava, S.K. (Santosh K.), Bi, Y. (Yufang), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Blokstra, A. (Anneke), Bo, S. (Simona), Boehm, B.O. (Bernhard), Boissonnet, C.P. (Carlos P.), Bovet, P. (Pascal), Brajkovich, I. (Imperia), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Brian, G.R. (Garry R.), Bruno, G. (Graziella), Bugge, A. (Anna), De León, A.C. (Antonio Cabrera), Can, G. (Günay), Cåndido, A.P.C. (Ana Paula C.), Capuano, V. (Vincenzo), Carlsson, A.C. (Axel C.), Carvalho, M.J. (Maria J.), Casanueva, F.F. (Felipe F.), Casas, J.P. (Juan Pablo), Caserta, C.A. (Carmelo A.), Castetbon, K., Chamukuttan, S. (Snehalatha), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, S. (Shuohua), Cheng, C.-Y. (Ching-Yu), Chetrit, A. (Angela), Chiou, S.-T. (Shu-Ti), Cho, Y. (Yumi), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F., Concin, H. (Hans), Cooper, C. (Charles), Cooper, R. (Rachel), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Crujeiras, A.B. (Ana B.), D'Arrigo, G. (Graziella), Dallongeville, J., Dankner, R. (Rachel), Dauchet, L. (Luc), De Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), Deepa, M. (Mohan), Dehghan, A. (Abbas), Deschamps, V. (Valerie), Dhana, K. (Klodian), Di Castelnuovo, A.F. (Augusto F.), Djalalinia, S. (Shirin), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Du, Y. (Yong), Dzerve, V. (Vilnis), Egbagbe, E.E. (Eruke E.), Eggertsen, R. (Robert), El Ati, J. (Jalila), Elosua, R. (Roberto), Erasmus, R.T. (Rajiv T.), Erem, C. (Cihangir), Ergor, G. (Gul), Eriksen, L. (Louise), Escobedo-De La Peña, J. (Jorge), Fall, C.H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Feskens, E.J.M. (Edith), Finn, J.D. (Joseph D.), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Francis, D.K. (Damian K.), Do Carmo Franco, M. (Maria), Franco, O.H. (Oscar), Frontera, G. (Guillermo), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Geleijnse, J.M. (Marianne), Ghasemian, A. (Anoosheh), Ghimire, A. (Anup), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Gross, M., Rivas, J.P.G. (Juan P. González), Gorbea, M.B. (Mariano Bonet), Gottrand, F. (Frederic), Grafnetter, D. (Dušan), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Gruden, G. (Grabriella), Gu, D. (Dongfeng), Guan, O.P. (Ong Peng), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A.L. (Andre L.), Gutierrez, L. (Laura), Hambleton, I.R. (Ian R.), Hardy, R., Kumar, R.H. (Rachakulla Hari), Hata, J. (Jun), He, J. (Jiang), Heidemann, C. (Christin), Herrala, S. (Sauli), Hihtaniemi, I.T. (Ilpo Tapani), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hofman, A. (Albert), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Hu, Y. (Yang), Hussieni, A.S. (Abdullatif S.), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (M. Mohsen), Ikeda, N. (Nayu), Ikram, M.A. (M. Arfan), Irazola, V. (Vilma), Islam, M. (Muhammad), Iwasaki, M. (Masanori), Jacobs, J.M. (Jeremy M.), Jafar, T.H. (Tazeen), Jamil, K.M. (Kazi M.), Jasienska, G. (Grazyna), Jiang, C.Q. (Chao Qiang), Jonas, J.B., Joshi, P. (Pradeep), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kasaeian, A. (Amir), Katz, J. (Joanne), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Kengne, A.P. (Andre Pascal), Kersting, M. (Mathilde), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khang, Y.-H. (Young-Ho), Kiechl, S. (Stefan), Kim, J. (Jeongseon), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Kratzer, W. (Wolfgang), Kromhout, D. (Daan), Kujala, U.M. (Urho), Kula, K. (Krzysztof), Kyobutungi, C. (Catherine), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Laxmaiah, A. (Avula), Leclercq, C. (Catherine), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehtimäki, T. (Terho), Lekhraj, R. (Rampal), León-Muñoz, L.M. (Luz M.), Li, Y. (Yanping), Lim, W.-Y. (Wei-Yen), Lima-Costa, M.F. (M. Fernanda), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Lissner, L. (Lauren), Lorbeer, R. (Roberto), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lytsy, P. (Per), Machado-Coelho, G.L.L. (George L.L.), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D.J., Makdisse, M. (Marcia), Rao, K.M. (Kodavanti Mallikharjuna), Manios, Y., Manzato, E. (Enzo), Margozzini, P. (Paula), Marques-Vidal, P. (Pedro), Martorell, R. (Reynaldo), Masoodi, S.R. (Shariq R.), Mathiesen, E.B. (Ellisiv), Matsha, T.E. (Tandi E.), McFarlane, S.R. (Shelly R.), McLachlan, S. (Stela), McNulty, B.A. (Breige A.), Mediene-Benchekor, S. (Sounnia), Meirhaeghe, A. (Aline), Menezes, A.M.B. (Ana Maria B.), Merat, S. (Shahin), Meshram, I.I. (Indrapal I.), Mi, J. (Jie), Miquel, J.F. (Juan Francisco), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohd Yusoff, M.F. (Muhammad Fadhli), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Mondo, C.K. (Charles K.), Morejon, A. (Alain), Moreno, L.A. (Luis A.), Morgan, K. (Karen), Moschonis, G., Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motta, J. (Jorge), Mu, T.T. (Thet Thet), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Mursu, J. (Jaakko), Nagel, G. (Gabriele), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, M. (Monika), Navarrete-Muñoz, E.M., Ndiaye, N.C. (Ndeye Coumba), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Noale, M. (Marianna), Noto, D. (Davide), Al Nsour, M. (Mohannad), Ochoa-Avilés, A.M. (Angélica M.), Oh, K. (Kyungwon), Ordunez, P. (Pedro), Osmond, C. (Clive), Otero, J.A. (Johanna A.), Owusu-Dabo, E. (Ellis), Pahomova, E. (Elena), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parsaeian, M. (Mahboubeh), Peixoto, S.V. (Sergio Viana), Peltonen, M. (Markku), Peters, A., Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pitakaka, F. (Freda), Piwonska, A. (Aleksandra), Piwonski, J. (Jerzy), Plans-Rubió, P. (Pedro), Porta, M., Portegies, M.L.P. (Marileen), Poustchi, H. (Hossein), Pradeepa, R. (Rajendra), Price, J.F. (Jackie F.), Punab, M. (Margus), Qasrawi, R.F. (Radwan F.), Qorbani, M. (Mostafa), Radisauskas, R. (Ricardas), Rahman, M. (Mahmudur), Raitakari, O. (Olli), Rao, S.R. (Sudha Ramachandra), Ramke, J. (Jacqueline), Ramos, R. (Rafel), Rampal, S. (Sanjay), Rathmann, W. (Wolfgang), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Rigo, F. (Fernando), Robinson, S.M. (Siân), Robitaille, C. (Cynthia), Rodríguez Artalejo, F. (Fernando), Del CristoRodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Rojas-Martinez, R. (Rosalba), Ronkainen, K. (Kimmo), Rosengren, A. (Annika), Rubinstein, A. (Adolfo), Rui, O. (Ornelas), Ruiz-Betancourt, B.S. (Blanca Sandra), Horimoto, A.R.V.R. (Andrea R.V. Russo), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Saidi, O. (Olfa), Sakarya, S. (Sibel), Salanave, B. (Benoit), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Santos, D. (Diana), Dos Santos, R.N. (Renata Nunes), Santos, R. (Rute), Saramies, J. (Jouko), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Scazufca, M. (Marcia), Schargrodsky, H. (Herman), Scheidt-Nave, C. (C.), Sein, A.A. (Aye Aye), Sharma, S.K. (Sanjb K.), Shaw, J.E., Shibuya, K. (Kenji), Shin, Y. (Youchan), Shiri, R. (Rahman), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon A.), Sjostrom, M. (Michael), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Snijder, M.B. (Marieke), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugène), Söderberg, S. (Stefan), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Soumare, A. (Aicha), Staessen, J.A. (Jan A.), Stathopoulou, M.G. (Maria G.), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stessman, J. (Jochanan), Stöckl, D. (Doris), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M.W. (Maria Wany), Sun, C.-A. (Chien-An), Sundstrom, J. (Johan), Sung, Y.-T. (Yn-Tz), Suriyawongpaisal, P. (Paibul), Sy, R.G. (Rody G.), Tai, E.S. (E. Shyong), Tamosiunas, A. (Abdonas), Tang, L. (Line), Tarawneh, M. (Mohammed), Tarqui-Mamani, C.B. (Carolina B), Taylor, A. (Anne), Theobald, H. (Holger), Thijs, L. (Lutgarde), Thuesen, L. (Leif), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne S.), Topbas, M. (Murat), Torrent, M. (Maties), Traissac, P. (Pierre), Trinh, O.T.H. (Oanh T.H.), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Turley, M.L. (Maria L.), Tzourio, C. (Christophe), Ueda, P. (Peter), Ukoli, F.A.M. (Flora A.M.), Ulmer, H. (Hanno), Uusitalo, H.M.T. (Hannu M.T.), Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), Rossem, L. (Lenie) van, Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Verschuren, W.M.M. (W.M. Monique), Verstraeten, R. (Roosmarijn), Viet, L. (Lucie), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Voutilainen, S. (Sari), Vrijheid, M. (Martine), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Wan Mohamud, W.N. (Wan Nazaimoon), Wang, F. (Feng), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. (Ying), Wannamethee, S.G. (Goya), Weerasekera, D. (Deepa), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Wiecek, A. (Andrzej), Wijga, A.H. (Alet), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C. (Frederick C.), Wu, S.L. (Shou Ling), Xu, H. (Haiquan), Yan, W. (Weili), Yang, X. (Xiaoguang), Ye, X. (Xingwang), Yoshihara, A. (Akihiro), Younger-Coleman, N.O. (Novie O.), Zambon, S. (Sabina), Zargar, A.H. (Abdul Hamid), Zdrojewski, T. (T.), Zhao, W. (Wenhua), Zheng, Y. (Yingfeng), Cisneros, J.Z. (Julio Zuñiga), Zhou, B. (Bin), Lu, Y. (Yuan), Hajifathalian, K. (Kaveh), Bentham, J. (James), Di Cesare, M. (Mariachiara), Danaei, G. (Goodarz), Bixby, H. (Honor), Cowan, M.J. (Melanie J.), Ali, M.K. (Mohammed), Taddei, C. (Cristina), Lo, W.-C. (Wei-Cheng), Reis-Santos, B. (Barbara), Stevens, G.A. (Gretchen A.), Riley, L.M. (Leanne M.), Miranda, J.J. (J. Jaime), Bjerregaard, P. (Peter), Rivera, J.A. (Juan A.), Fouad, H.M. (Heba M.), Ma, G. (Guansheng), Mbanya, J.C.N. (Jean Claude N.), McGarvey, S.T. (Stephen T.), Mohan, V. (Viswanathan), Onat, A. (Altan), Pilav, A. (Aida), Ramachandran, A. (Ambady), Ben Romdhane, H. (Habiba), Paciorek, C.J. (Christopher J.), Bennett, J.E. (James E.), Ezzati, M. (Majid), Abdeen, Z.A. (Ziad A.), Kadir, K.A. (Khalid Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Aguilar-Salinas, C.A. (Carlos), Agyemang, C.O. (Charles), Ahmadvand, A. (Alireza), Al-Othman, A.R. (Amani Rashed), Alkerwi, A. (Ala'a), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Bo Andersen, L. (Lars), Anderssen, S.A. (Sigmund A.), Anjana, R.M. (Ranjit Mohan), Aounallah-Skhiri, H. (Hajer), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Arveiler, D. (Dominique), Assah, F.K. (Felix K.), Avdicová, M. (Mária), Azizi, J. (Joshan), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Batieha, A.M. (Anwar M.), Baur, L.A. (Louise A.), Benet, M. (Mikhail), Bernabe-Ortiz, A. (Antonio), Bharadwaj, S. (Sumit), Bhargava, S.K. (Santosh K.), Bi, Y. (Yufang), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Blokstra, A. (Anneke), Bo, S. (Simona), Boehm, B.O. (Bernhard), Boissonnet, C.P. (Carlos P.), Bovet, P. (Pascal), Brajkovich, I. (Imperia), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Brian, G.R. (Garry R.), Bruno, G. (Graziella), Bugge, A. (Anna), De León, A.C. (Antonio Cabrera), Can, G. (Günay), Cåndido, A.P.C. (Ana Paula C.), Capuano, V. (Vincenzo), Carlsson, A.C. (Axel C.), Carvalho, M.J. (Maria J.), Casanueva, F.F. (Felipe F.), Casas, J.P. (Juan Pablo), Caserta, C.A. (Carmelo A.), Castetbon, K., Chamukuttan, S. (Snehalatha), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, S. (Shuohua), Cheng, C.-Y. (Ching-Yu), Chetrit, A. (Angela), Chiou, S.-T. (Shu-Ti), Cho, Y. (Yumi), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F., Concin, H. (Hans), Cooper, C. (Charles), Cooper, R. (Rachel), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Crujeiras, A.B. (Ana B.), D'Arrigo, G. (Graziella), Dallongeville, J., Dankner, R. (Rachel), Dauchet, L. (Luc), De Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), Deepa, M. (Mohan), Dehghan, A. (Abbas), Deschamps, V. (Valerie), Dhana, K. (Klodian), Di Castelnuovo, A.F. (Augusto F.), Djalalinia, S. (Shirin), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Du, Y. (Yong), Dzerve, V. (Vilnis), Egbagbe, E.E. (Eruke E.), Eggertsen, R. (Robert), El Ati, J. (Jalila), Elosua, R. (Roberto), Erasmus, R.T. (Rajiv T.), Erem, C. (Cihangir), Ergor, G. (Gul), Eriksen, L. (Louise), Escobedo-De La Peña, J. (Jorge), Fall, C.H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Feskens, E.J.M. (Edith), Finn, J.D. (Joseph D.), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Francis, D.K. (Damian K.), Do Carmo Franco, M. (Maria), Franco, O.H. (Oscar), Frontera, G. (Guillermo), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Geleijnse, J.M. (Marianne), Ghasemian, A. (Anoosheh), Ghimire, A. (Anup), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Gross, M., Rivas, J.P.G. (Juan P. González), Gorbea, M.B. (Mariano Bonet), Gottrand, F. (Frederic), Grafnetter, D. (Dušan), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Gruden, G. (Grabriella), Gu, D. (Dongfeng), Guan, O.P. (Ong Peng), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A.L. (Andre L.), Gutierrez, L. (Laura), Hambleton, I.R. (Ian R.), Hardy, R., Kumar, R.H. (Rachakulla Hari), Hata, J. (Jun), He, J. (Jiang), Heidemann, C. (Christin), Herrala, S. (Sauli), Hihtaniemi, I.T. (Ilpo Tapani), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hofman, A. (Albert), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Hu, Y. (Yang), Hussieni, A.S. (Abdullatif S.), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (M. Mohsen), Ikeda, N. (Nayu), Ikram, M.A. (M. Arfan), Irazola, V. (Vilma), Islam, M. (Muhammad), Iwasaki, M. (Masanori), Jacobs, J.M. (Jeremy M.), Jafar, T.H. (Tazeen), Jamil, K.M. (Kazi M.), Jasienska, G. (Grazyna), Jiang, C.Q. (Chao Qiang), Jonas, J.B., Joshi, P. (Pradeep), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kasaeian, A. (Amir), Katz, J. (Joanne), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Kengne, A.P. (Andre Pascal), Kersting, M. (Mathilde), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khang, Y.-H. (Young-Ho), Kiechl, S. (Stefan), Kim, J. (Jeongseon), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Kratzer, W. (Wolfgang), Kromhout, D. (Daan), Kujala, U.M. (Urho), Kula, K. (Krzysztof), Kyobutungi, C. (Catherine), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Laxmaiah, A. (Avula), Leclercq, C. (Catherine), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehtimäki, T. (Terho), Lekhraj, R. (Rampal), León-Muñoz, L.M. (Luz M.), Li, Y. (Yanping), Lim, W.-Y. (Wei-Yen), Lima-Costa, M.F. (M. Fernanda), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Lissner, L. (Lauren), Lorbeer, R. (Roberto), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lytsy, P. (Per), Machado-Coelho, G.L.L. (George L.L.), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D.J., Makdisse, M. (Marcia), Rao, K.M. (Kodavanti Mallikharjuna), Manios, Y., Manzato, E. (Enzo), Margozzini, P. (Paula), Marques-Vidal, P. (Pedro), Martorell, R. (Reynaldo), Masoodi, S.R. (Shariq R.), Mathiesen, E.B. (Ellisiv), Matsha, T.E. (Tandi E.), McFarlane, S.R. (Shelly R.), McLachlan, S. (Stela), McNulty, B.A. (Breige A.), Mediene-Benchekor, S. (Sounnia), Meirhaeghe, A. (Aline), Menezes, A.M.B. (Ana Maria B.), Merat, S. (Shahin), Meshram, I.I. (Indrapal I.), Mi, J. (Jie), Miquel, J.F. (Juan Francisco), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohd Yusoff, M.F. (Muhammad Fadhli), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Mondo, C.K. (Charles K.), Morejon, A. (Alain), Moreno, L.A. (Luis A.), Morgan, K. (Karen), Moschonis, G., Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motta, J. (Jorge), Mu, T.T. (Thet Thet), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Mursu, J. (Jaakko), Nagel, G. (Gabriele), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, M. (Monika), Navarrete-Muñoz, E.M., Ndiaye, N.C. (Ndeye Coumba), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Noale, M. (Marianna), Noto, D. (Davide), Al Nsour, M. (Mohannad), Ochoa-Avilés, A.M. (Angélica M.), Oh, K. (Kyungwon), Ordunez, P. (Pedro), Osmond, C. (Clive), Otero, J.A. (Johanna A.), Owusu-Dabo, E. (Ellis), Pahomova, E. (Elena), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parsaeian, M. (Mahboubeh), Peixoto, S.V. (Sergio Viana), Peltonen, M. (Markku), Peters, A., Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pitakaka, F. (Freda), Piwonska, A. (Aleksandra), Piwonski, J. (Jerzy), Plans-Rubió, P. (Pedro), Porta, M., Portegies, M.L.P. (Marileen), Poustchi, H. (Hossein), Pradeepa, R. (Rajendra), Price, J.F. (Jackie F.), Punab, M. (Margus), Qasrawi, R.F. (Radwan F.), Qorbani, M. (Mostafa), Radisauskas, R. (Ricardas), Rahman, M. (Mahmudur), Raitakari, O. (Olli), Rao, S.R. (Sudha Ramachandra), Ramke, J. (Jacqueline), Ramos, R. (Rafel), Rampal, S. (Sanjay), Rathmann, W. (Wolfgang), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Rigo, F. (Fernando), Robinson, S.M. (Siân), Robitaille, C. (Cynthia), Rodríguez Artalejo, F. (Fernando), Del CristoRodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Rojas-Martinez, R. (Rosalba), Ronkainen, K. (Kimmo), Rosengren, A. (Annika), Rubinstein, A. (Adolfo), Rui, O. (Ornelas), Ruiz-Betancourt, B.S. (Blanca Sandra), Horimoto, A.R.V.R. (Andrea R.V. Russo), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Saidi, O. (Olfa), Sakarya, S. (Sibel), Salanave, B. (Benoit), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Santos, D. (Diana), Dos Santos, R.N. (Renata Nunes), Santos, R. (Rute), Saramies, J. (Jouko), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Scazufca, M. (Marcia), Schargrodsky, H. (Herman), Scheidt-Nave, C. (C.), Sein, A.A. (Aye Aye), Sharma, S.K. (Sanjb K.), Shaw, J.E., Shibuya, K. (Kenji), Shin, Y. (Youchan), Shiri, R. (Rahman), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon A.), Sjostrom, M. (Michael), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Snijder, M.B. (Marieke), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugène), Söderberg, S. (Stefan), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Soumare, A. (Aicha), Staessen, J.A. (Jan A.), Stathopoulou, M.G. (Maria G.), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stessman, J. (Jochanan), Stöckl, D. (Doris), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M.W. (Maria Wany), Sun, C.-A. (Chien-An), Sundstrom, J. (Johan), Sung, Y.-T. (Yn-Tz), Suriyawongpaisal, P. (Paibul), Sy, R.G. (Rody G.), Tai, E.S. (E. Shyong), Tamosiunas, A. (Abdonas), Tang, L. (Line), Tarawneh, M. (Mohammed), Tarqui-Mamani, C.B. (Carolina B), Taylor, A. (Anne), Theobald, H. (Holger), Thijs, L. (Lutgarde), Thuesen, L. (Leif), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne S.), Topbas, M. (Murat), Torrent, M. (Maties), Traissac, P. (Pierre), Trinh, O.T.H. (Oanh T.H.), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Turley, M.L. (Maria L.), Tzourio, C. (Christophe), Ueda, P. (Peter), Ukoli, F.A.M. (Flora A.M.), Ulmer, H. (Hanno), Uusitalo, H.M.T. (Hannu M.T.), Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), Rossem, L. (Lenie) van, Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Verschuren, W.M.M. (W.M. Monique), Verstraeten, R. (Roosmarijn), Viet, L. (Lucie), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Voutilainen, S. (Sari), Vrijheid, M. (Martine), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Wan Mohamud, W.N. (Wan Nazaimoon), Wang, F. (Feng), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. (Ying), Wannamethee, S.G. (Goya), Weerasekera, D. (Deepa), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Wiecek, A. (Andrzej), Wijga, A.H. (Alet), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C. (Frederick C.), Wu, S.L. (Shou Ling), Xu, H. (Haiquan), Yan, W. (Weili), Yang, X. (Xiaoguang), Ye, X. (Xingwang), Yoshihara, A. (Akihiro), Younger-Coleman, N.O. (Novie O.), Zambon, S. (Sabina), Zargar, A.H. (Abdul Hamid), Zdrojewski, T. (T.), Zhao, W. (Wenhua), Zheng, Y. (Yingfeng), and Cisneros, J.Z. (Julio Zuñiga)
Abstract: Background: One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are aff ecting the number of adults with diabetes. Methods: We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence-defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs-in 200 countries and territories in 21 regions, by sex and from 1980 to 2014. We also calculated the posterior probability of meeting the global diabetes target if post-2000 trends continue. Findings: We used data from 751 studies including 4372000 adults from 146 of the 200 countries we make estimates for. Global age-standardised diabetes prevalence increased from 4.3% (95% credible interval 2.4-17.0) in 1980 to 9.0% (7.2-11.1) in 2014 in
Published: 2016
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16. A century of trends in adult human height

Author: Bentham, J. (James), Di Cesare, M. (Mariachiara), Stevens, G.A. (Gretchen A.), Zhou, B. (Bin), Bixby, H. (Honor), Cowan, M. (Melanie), Fortunato, L. (Léa), Bennett, J.E. (James E.), Danaei, G. (Goodarz), Hajifathalian, K. (Kaveh), Lu, Y. (Yuan), Riley, L.M. (Leanne M.), Laxmaiah, A. (Avula), Kontis, V. (Vasilis), Paciorek, C.J. (Christopher J.), Ezzati, M. (Majid), Abdeen, Z.A. (Ziad A.), Hamid, Z.A. (Zargar Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Aguilar-Salinas, C.A. (Carlos), Agyemang, C.O. (Charles), Ahmadvand, A. (Alireza), Ahrens, W. (W.), Al-Hazzaa, H.M. (Hazzaa M.), Al-Othman, A.R. (Amani Rashed), Raddadi, R.A. (Rajaa Al), Ali, M.M. (Mohamed M.), Alkerwi, A. (Ala’a), Alvarez-Pedrerol, M. (Mar), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L.B. (Lars Bo), Anderssen, S.A. (Sigmund A.), Anjana, R.M. (Ranjit Mohan), Aounallah-Skhiri, H. (Hajer), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Arveiler, D. (Dominique), Assah, F.K. (Felix K.), Avdicová, M. (Mária), Azizi, J. (Joshan), Babu, B.V. (Bontha V.), Bahijri, S. (Suhad), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J.R. (José R.), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Barkat, A. (Amina), Barros, M.V. (Mauro V.), Bata, I. (Iqbal), Batieha, A.M. (Anwar M.), Batista, R.L. (Rosangela L.), Baur, L.A. (Louise A.), Beaglehole, R. (Robert), Romdhane, H.B. (Habiba Ben), Benet, M. (Mikhail), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S.K. (Santosh K.), Bhatti, Z. (Zaid), Bhutta, Z.A. (Zulfiqar A), Bi, H. (Hongsheng), Bi, Y. (Yufang), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boddy, L.M. (Lynne M.), Boehm, B.O. (Bernhard), Boeing, H. (Heiner), Boissonnet, C.P. (Carlos P.), Bongard, V. (Vanina), Bovet, P. (Pascal), Braeckman, L. (Lutgart), Bragt, M.C.E. (Marjolijn C. E.), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Brian, G.R. (Garry R.), Bruno, G. (Graziella), Bueno-de-Mesquita, H.B. (H. Bas), Bugge, A. (Anna), Burns, C. (Con), De León, A.C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Cama, T. (Tilema), Cameron, C. (Christine), Camolas, J. (José), Can, G. (Günay), Cândido, A.P.C. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V.C. (Viviane C.), Carlsson, A.C. (Axel C.), Carvalho, M.J. (Maria J.), Casanueva, F.F. (Felipe F.), Casas, J.P. (Juan Pablo), Caserta, C.A. (Carmelo A.), Chamukuttan, S. (Snehalatha), Chan, A.W.M. (Angelique), Chan, Q. (Queenie), Chaturvedi, H.K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, B. (Belong), Cho, Y. (Yumi), Christensen, K. (Kaare), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F., Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Charles), Cooper, R. (Rachel), Coppinger, T.C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C.L. (Cora L.), Crujeiras, A.B. (Ana B.), D’Arrigo, G. (Graziella), d’Orsi, E. (Eleonora), Dallongeville, J., Damasceno, A. (Albertino), Damsgaard, C.T. (Camilla T.), Dankner, R. (Rachel), Dauchet, L. (Luc), De Backer, G. (Guy), De Bacquer, D. (Dirk), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A.D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Hélène), Delpeuch, F. (Francis), Deschamps, V. (Valérie), Dhana, K. (Klodian), Di Castelnuovo, A.F. (Augusto F.), Dias-da-Costa, J.S. (Juvenal Soares), Diaz, A. (Alejandro), Djalalinia, S. (Shirin), Do, H.T.P. (Ha T. P.), Dobson, A.J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S.P. (Silvana P.), Döring, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Dzerve, V. (Vilnis), Egbagbe, E.E. (Eruke E.), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Elliott, P. (Paul), Engle-Stone, R. (Reina), Erasmus, R.T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), Escobedo-de la Peña, J. (Jorge), Evans, A. (Alun), Faeh, D. (David), Fall, C.H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J.D. (Joseph D.), Fischer, K. (Krista), Flores, E.M. (Eric Monterubio), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fortmann, S.P. (Stephen), Fouad, H.M. (Heba M.), Francis, D.K. (Damian K.), Do Carmo Franco, M. (Maria), Franco, O.H. (Oscar), Frontera, G. (Guillermo), Fuchs, F.D. (Flavio D.), Fuchs, S.C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gafencu, M. (Mihai), Gareta, D. (Dickman), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Geleijnse, J.M. (Marianne), Ghasemian, A. (Anoosheh), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Goldsmith, R.A. (Rebecca A.), Gonçalves, H. (Helen), Gross, M., González Rivas, J.P. (Juan P.), Gorbea, M.B. (Mariano Bonet), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dušan), Grajda, A. (Aneta), Grammatikopoulou, M.G. (Maria G.), Gregor, R.D. (Ronald D.), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Gu, D. (Dongfeng), Gualdi-Russo, E. (Emanuela), Guan, O.P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A.L. (Andre L.), Gulliford, M.C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Gunter, M. (Marc), Guo, X. (Xiuhua), Guo, Y. (Yin), Gupta, P.C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Halkjær, J., Hambleton, I.R. (Ian R.), Hardy, R., Kumar, R.H. (Rachakulla Hari), Hata, J. (Jun), Hayes, A.J. (Alison J.), He, J. (Jiang), Hendriks, M.E. (Marleen), Cadena, L.H. (Leticia Hernandez), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hihtaniemi, I.T. (Ilpo Tapani), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Hu, Y. (Yonghua), Husseini, A. (Abdullatif), Huu, C.N. (Chinh Nguyen), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (Mohsen M.), Ikeda, N. (Nayu), Ikram, M.A. (Arfan), Irazola, V. (Vilma), Islam, M. (Muhammad), Ivkovic, V. (Vanja), Iwasaki, M. (Masanori), Jackson, R.T. (Rod T.), Jacobs, J.M. (Jeremy M.), Jafar, T.H. (Tazeen), Jamil, K.M. (Kazi M.), Jamrozik, K., Janszky, I. (Imre), Jasienska, G. (Grazyna), Jelakovic, B. (Bojan), Jiang, C.Q. (Chao Qiang), Joffres, M. (Michel), Johansson, M. (Mattias), Jonas, J.B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Jureša, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kapantais, E. (Efthymios), Kasaeian, A. (Amir), Katz, J. (Joanne), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Keil, M. (Mark), Boker, L.K. (Lital Keinan), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Kemper, H.C.G., Kengne, A.P. (Andre Pascal), Kersting, M. (Mathilde), Key, T. (Tim), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khang, Y.-H. (Young-Ho), Khaw, K.-T. (Kay-Tee), Khouw, I.M.S.L. (Ilse M. S. L.), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Klimont, J. (Jeannette), Klumbiene, J. (Jurate), Koirala, B. (Bhawesh), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kratzer, W. (Wolfgang), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H.S. (Herculina S.), Kubinova, R., Kujala, U.M. (Urho), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Krishna Kumar, R., Kurjata, P. (Pawel), Kusuma, Y.S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Kyobutungi, C. (Catherine), Laamiri, F.Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Laugsand, L.E. (Lars E.), Bao, K.L.N. (Khanh Le Nguyen), Le, T.D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J.J.M. (Jeannette), Lee, J. (Jeonghee), Lehtimäki, T. (Terho), Lekhraj, R. (Rampal), León-Muñoz, L.M. (Luz M.), Li, Y. (Yanping), Lilly, C.L. (Christa L.), Lim, W.-Y. (Wei-Yen), Fernanda Lima-Costa, M., Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Liu, J. (Jing), Lorbeer, R. (Roberto), Lotufo, P.A. (Paulo A), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Ma, J. (Jun), Machado-Coelho, G.L.L. (George L. L.), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D.J., Maire, B. (Bernard), Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K.M. (Kodavanti Mallikharjuna), Malyutina, S., Manios, Y., Mann, J.I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Markey, O. (Oonagh), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martin-Prevel, Y. (Yves), Martorell, R. (Reynaldo), Masoodi, S.R. (Shariq R.), Mathiesen, E.B. (Ellisiv), Matsha, T.E. (Tandi E.), Mazur, A. (Artur), Mbanya, J.C.N. (Jean Claude N.), McFarlane, S.R. (Shelly R.), McGarvey, S.T. (Stephen T.), McKee, M. (Martin), McLachlan, S. (Stela), McLean, R.M. (Rachael M.), McNulty, B.A. (Breige A.), Yusof, S.M. (Safiah Md), Mediene-Benchekor, S. (Sounnia), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A.M.B. (Ana Maria B.), Mensink, G.B.M. (Gert B. M.), Meshram, I.I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Michaelsen, K.F., Mikkel, K. (Kairit), Miller, J.C. (Jody C.), Miquel, J.F. (Juan Francisco), Jaime Miranda, J., Mišigoj-Durakovic, M. (Marjeta), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M.F.M. (Muhammad Fadhli Mohd), Molbo, D. (Drude), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Mondo, C.K. (Charles K.), Monterrubio, E.A. (Eric A.), Monyeki, K.D.K. (Kotsedi Daniel K.), Moreira, L.B. (Leila B.), Morejon, A. (Alain), Moreno, L.A. (Luis A.), Morgan, K. (Karen), Mortensen, E.L. (Erik Lykke), Moschonis, G., Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M.E. (Mohammad Esmaeel), Motta, J. (Jorge), Mu, T.T. (Thet Thet), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Murtagh, E.M. (Elaine M.), Musa, K.I. (Kamarul Imran), Musil, V. (Vera), Nagel, G. (Gabriele), Nakamura, H. (Harunobu), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, M. (Monika), Nankap, M. (Martin), Narake, S. (Sameer), Navarrete-Muñoz, E.M., Neal, W.A. (William A.), Nenko, I. (Ilona), Neovius, M. (Martin), Nervi, F. (Flavio), Neuhauser, H.K. (Hannelore K.), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Norat, T. (Teresa), Noto, D. (Davide), Nsour, M.A. (Mohannad Al), O’Reilly, D. (Dermot), Oh, K. (Kyungwon), Olayan, I.H. (Iman H.), Olinto, M.T.A. (Maria Teresa Anselmo), Oltarzewski, M. (Maciej), Omar, M.A. (Mohd A.), Onat, A. (Altan), Ordunez, P. (Pedro), Ortiz, A.P. (Ana P.), Osler, M. (Merete), Osmond, C. (Clive), Ostojic, S.M. (Sergej M.), Otero, J.A. (Johanna A.), Overvad, K. (Kim), Owusu-Dabo, E. (Ellis), Paccaud, F.M. (Fred Michel), Padez, C. (Cristina), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palli, D. (Domenico), Palloni, A. (Alberto), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W.R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pecin, I. (Ivan), Pednekar, M.S. (Mangesh S.), Peeters, P.H.M., Peixoto, S.V. (Sergio Viana), Peltonen, M. (Markku), Pereira, A. (A.), Pérez, C.M. (Cynthia M.), Peters, A., Petkeviciene, J. (Janina), Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, A. (Alberto), Pistelli, F. (Francesco), Pitakaka, F. (Freda), Piwonska, A. (Aleksandra), Plans-Rubió, P. (Pedro), Poh, B.K. (Bee Koon), Porta, M., Portegies, M.L.P. (Marileen), Poulimeneas, D. (Dimitrios), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J.F. (Jackie F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R.F. (Radwan F.), Qorbani, M. (Mostafa), Bao, T.Q. (Tran Quoc), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M.-M. (Mah-mudur), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S.R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramke, J. (Jacqueline), Ramos, R. (Rafel), Rampal, S. (Sanjay), Rasmussen, F. (Finn), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), Rinke de Wit, T.F. (Tobias), Ritti-Dias, R.M. (Raphael M.), Rivera, J.A. (Juan A.), Robinson, S.M. (Siân), Robitaille, C. (Cynthia), Rodríguez Artalejo, F. (Fernando), Del Cristo Rodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rojroong-Wasinkul, N. (Nipa), Romaguera, D. (Dora), Ronkainen, K. (Kimmo), Rosengren, A. (Annika), Rouse, I. (Ian), Rubinstein, A. (Adolfo), Rühli, F.J. (Frank J.), Rui, O. (Ornelas), Ruiz-Betancourt, B.S. (Blanca Sandra), Russo Horimoto, A.R.V. (Andrea R. V.), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Saidi, O. (Olfa), Salanave, B. (Benoit), Martinez, E.S. (Eduardo Salazar), Salomaa, V. (Veikko), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Sandjaja, Sans, S. (Susana), Santos, D.A. (Diana A.), Santos, O. (Osvaldo), Dos Santos, R.N. (Renata Nunes), Santos, R. (Rute), Saramies, J. (Jouko), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S., Scazufca, M. (Marcia), Rosario, A.S. (Angelika Schaffrath), Schargrodsky, H. (Herman), Schienkiewitz, A. (Anja), Schmidt, I.M. (Ida Maria), Schneider, I.J.C. (Ione J C), Schultsz, C. (Constance), Schutte, A.E. (Aletta E.), Sein, A.A. (Aye Aye), Sen, A. (Abhijit), Senbanjo, I.O. (Idowu O.), Sepanlou, S.G. (Sadaf G), Shalnova, S.A. (Svetlana A.), Sharma, S.K. (Sanjib K.), Shaw, J.E., Shibuya, K. (Kenji), Shin, D.W. (Dong Wook), Shin, Y. (Youchan), Shiri, R. (Rahman), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Silva, A.M. (Antonio M.), Silva, D.A.S. (Diego Augusto Santos), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon), Sjostrom, M. (Michael), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Smith, M.C. (Margaret C.), Snijder, M.B. (Marieke), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugène), Söderberg, S. (Stefan), Soekatri, M.Y.E. (Moesijanti Y. E.), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Song, Y. (Yi), Sørensen, T.I.A. (Thorkild), Soric, M. (Maroje), Jérome, C.S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J.A. (Jan), Starc, G. (Gregor), Stathopoulou, M.G. (Maria G.), Staub, K. (Kaspar), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stergiou, G.S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stöckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stratton, G. (Gareth), Stronks, K. (Karien), Strufaldi, M.W. (Maria Wany), Sun, C.-A. (Chien-An), Sundström, J. (Johan), Sung, Y.-T. (Yn-Tz), Sunyer, J. (Jordi), Suriyawongpaisal, P. (Paibul), Swinburn, B.A. (Boyd A.), Sy, R.G. (Rody G.), Szponar, L. (Lucjan), Shyong Tai, E., Tammesoo, M.L., Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M.R. (Mohammed Rasoul), Tarp, J. (Jakob), Tarqui-Mamani, C.B. (Carolina B.), Taylor, A. (Anne), Tchibindat, F. (Félicité), Theobald, H. (Holger), Thijs, L. (Lutgarde), Thuesen, L. (Leif), Tjønneland, A. (Anne), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne S.), Topbas, M. (Murat), Topór-Madry, R. (Roman), Torrent, M. (Maties), Toselli, S. (Stefania), Traissac, P. (Pierre), Trichopoulou, A. (Antonia), Trichopoulos, D. (Dimitrios), Trinh, O.T.H. (Oanh T. H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Turley, M.L. (Maria L.), Tynelius, P. (Per), Tzotzas, T. (Themistoklis), Tzourio, C. (Christophe), Ueda, P. (Peter), Ukoli, F.A.M. (Flora A. M.), Ulmer, H. (Hanno), Unal, B. (Belgin), Uusitalo, H.M.T. (Hannu M. T.), Valdivia, G. (Gonzalo), Vale, S. (Susana), Valvi, D. (Damaskini), Schouw, Y.T. (Yvonne) van der, Van Herck, K. (Koen), Van Minh, H. (Hoang), Rossem, L. (Lenie) van, Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Monique Verschuren, W.M., Verstraeten, R. (Roosmarijn), Victora, C.G. (Cesar G.), Viegi, G., Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Voutilainen, S. (Sari), Vrdoljak, A. (Ana), Vrijheid, M. (Martine), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W.N.W. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. (Ying), Goya Wannamethee, S., Wareham, N.J. (Nick), Weerasekera, D. (Deepa), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Widyahening, I.S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A.H. (Alet), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong, J.E. (Jyh Eiin), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C.W. (Frederick C.), Wu, J. (Jianfeng), Wu, S.L. (Shou Ling), Xu, H. (Haiquan), Xu, L. (Liang), Yamborisut, U. (Uruwan), Yan, W. (Weili), Yang, X. (Xiaoguang), Yardim, N. (Nazan), Ye, X. (Xingwang), Yiallouros, P.K. (P.), Yoshihara, A. (Akihiro), You, Q.S. (Qi Sheng), Younger-Coleman, N.O. (Novie O.), Yusoff, A.F. (Ahmad F.), Zainuddin, A.A. (Ahmad A.), Zambon, S. (Sabina), Zdrojewski, T. (T.), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingfeng), Zhou, M. (Ming), Zhu, D. (Dan), Zimmermann, E., Cisneros, J.Z. (Julio Zuñiga), Bentham, J. (James), Di Cesare, M. (Mariachiara), Stevens, G.A. (Gretchen A.), Zhou, B. (Bin), Bixby, H. (Honor), Cowan, M. (Melanie), Fortunato, L. (Léa), Bennett, J.E. (James E.), Danaei, G. (Goodarz), Hajifathalian, K. (Kaveh), Lu, Y. (Yuan), Riley, L.M. (Leanne M.), Laxmaiah, A. (Avula), Kontis, V. (Vasilis), Paciorek, C.J. (Christopher J.), Ezzati, M. (Majid), Abdeen, Z.A. (Ziad A.), Hamid, Z.A. (Zargar Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Aguilar-Salinas, C.A. (Carlos), Agyemang, C.O. (Charles), Ahmadvand, A. (Alireza), Ahrens, W. (W.), Al-Hazzaa, H.M. (Hazzaa M.), Al-Othman, A.R. (Amani Rashed), Raddadi, R.A. (Rajaa Al), Ali, M.M. (Mohamed M.), Alkerwi, A. (Ala’a), Alvarez-Pedrerol, M. (Mar), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L.B. (Lars Bo), Anderssen, S.A. (Sigmund A.), Anjana, R.M. (Ranjit Mohan), Aounallah-Skhiri, H. (Hajer), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Arveiler, D. (Dominique), Assah, F.K. (Felix K.), Avdicová, M. (Mária), Azizi, J. (Joshan), Babu, B.V. (Bontha V.), Bahijri, S. (Suhad), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J.R. (José R.), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Barkat, A. (Amina), Barros, M.V. (Mauro V.), Bata, I. (Iqbal), Batieha, A.M. (Anwar M.), Batista, R.L. (Rosangela L.), Baur, L.A. (Louise A.), Beaglehole, R. (Robert), Romdhane, H.B. (Habiba Ben), Benet, M. (Mikhail), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S.K. (Santosh K.), Bhatti, Z. (Zaid), Bhutta, Z.A. (Zulfiqar A), Bi, H. (Hongsheng), Bi, Y. (Yufang), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boddy, L.M. (Lynne M.), Boehm, B.O. (Bernhard), Boeing, H. (Heiner), Boissonnet, C.P. (Carlos P.), Bongard, V. (Vanina), Bovet, P. (Pascal), Braeckman, L. (Lutgart), Bragt, M.C.E. (Marjolijn C. E.), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Brian, G.R. (Garry R.), Bruno, G. (Graziella), Bueno-de-Mesquita, H.B. (H. Bas), Bugge, A. (Anna), Burns, C. (Con), De León, A.C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Cama, T. (Tilema), Cameron, C. (Christine), Camolas, J. (José), Can, G. (Günay), Cândido, A.P.C. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V.C. (Viviane C.), Carlsson, A.C. (Axel C.), Carvalho, M.J. (Maria J.), Casanueva, F.F. (Felipe F.), Casas, J.P. (Juan Pablo), Caserta, C.A. (Carmelo A.), Chamukuttan, S. (Snehalatha), Chan, A.W.M. (Angelique), Chan, Q. (Queenie), Chaturvedi, H.K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, B. (Belong), Cho, Y. (Yumi), Christensen, K. (Kaare), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F., Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Charles), Cooper, R. (Rachel), Coppinger, T.C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C.L. (Cora L.), Crujeiras, A.B. (Ana B.), D’Arrigo, G. (Graziella), d’Orsi, E. (Eleonora), Dallongeville, J., Damasceno, A. (Albertino), Damsgaard, C.T. (Camilla T.), Dankner, R. (Rachel), Dauchet, L. (Luc), De Backer, G. (Guy), De Bacquer, D. (Dirk), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A.D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Hélène), Delpeuch, F. (Francis), Deschamps, V. (Valérie), Dhana, K. (Klodian), Di Castelnuovo, A.F. (Augusto F.), Dias-da-Costa, J.S. (Juvenal Soares), Diaz, A. (Alejandro), Djalalinia, S. (Shirin), Do, H.T.P. (Ha T. P.), Dobson, A.J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S.P. (Silvana P.), Döring, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Dzerve, V. (Vilnis), Egbagbe, E.E. (Eruke E.), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Elliott, P. (Paul), Engle-Stone, R. (Reina), Erasmus, R.T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), Escobedo-de la Peña, J. (Jorge), Evans, A. (Alun), Faeh, D. (David), Fall, C.H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J.D. (Joseph D.), Fischer, K. (Krista), Flores, E.M. (Eric Monterubio), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fortmann, S.P. (Stephen), Fouad, H.M. (Heba M.), Francis, D.K. (Damian K.), Do Carmo Franco, M. (Maria), Franco, O.H. (Oscar), Frontera, G. (Guillermo), Fuchs, F.D. (Flavio D.), Fuchs, S.C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gafencu, M. (Mihai), Gareta, D. (Dickman), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Geleijnse, J.M. (Marianne), Ghasemian, A. (Anoosheh), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Goldsmith, R.A. (Rebecca A.), Gonçalves, H. (Helen), Gross, M., González Rivas, J.P. (Juan P.), Gorbea, M.B. (Mariano Bonet), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dušan), Grajda, A. (Aneta), Grammatikopoulou, M.G. (Maria G.), Gregor, R.D. (Ronald D.), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Gu, D. (Dongfeng), Gualdi-Russo, E. (Emanuela), Guan, O.P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A.L. (Andre L.), Gulliford, M.C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Gunter, M. (Marc), Guo, X. (Xiuhua), Guo, Y. (Yin), Gupta, P.C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Halkjær, J., Hambleton, I.R. (Ian R.), Hardy, R., Kumar, R.H. (Rachakulla Hari), Hata, J. (Jun), Hayes, A.J. (Alison J.), He, J. (Jiang), Hendriks, M.E. (Marleen), Cadena, L.H. (Leticia Hernandez), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hihtaniemi, I.T. (Ilpo Tapani), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Hu, Y. (Yonghua), Husseini, A. (Abdullatif), Huu, C.N. (Chinh Nguyen), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (Mohsen M.), Ikeda, N. (Nayu), Ikram, M.A. (Arfan), Irazola, V. (Vilma), Islam, M. (Muhammad), Ivkovic, V. (Vanja), Iwasaki, M. (Masanori), Jackson, R.T. (Rod T.), Jacobs, J.M. (Jeremy M.), Jafar, T.H. (Tazeen), Jamil, K.M. (Kazi M.), Jamrozik, K., Janszky, I. (Imre), Jasienska, G. (Grazyna), Jelakovic, B. (Bojan), Jiang, C.Q. (Chao Qiang), Joffres, M. (Michel), Johansson, M. (Mattias), Jonas, J.B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Jureša, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kapantais, E. (Efthymios), Kasaeian, A. (Amir), Katz, J. (Joanne), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Keil, M. (Mark), Boker, L.K. (Lital Keinan), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Kemper, H.C.G., Kengne, A.P. (Andre Pascal), Kersting, M. (Mathilde), Key, T. (Tim), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khang, Y.-H. (Young-Ho), Khaw, K.-T. (Kay-Tee), Khouw, I.M.S.L. (Ilse M. S. L.), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Klimont, J. (Jeannette), Klumbiene, J. (Jurate), Koirala, B. (Bhawesh), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kratzer, W. (Wolfgang), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H.S. (Herculina S.), Kubinova, R., Kujala, U.M. (Urho), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Krishna Kumar, R., Kurjata, P. (Pawel), Kusuma, Y.S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Kyobutungi, C. (Catherine), Laamiri, F.Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Laugsand, L.E. (Lars E.), Bao, K.L.N. (Khanh Le Nguyen), Le, T.D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J.J.M. (Jeannette), Lee, J. (Jeonghee), Lehtimäki, T. (Terho), Lekhraj, R. (Rampal), León-Muñoz, L.M. (Luz M.), Li, Y. (Yanping), Lilly, C.L. (Christa L.), Lim, W.-Y. (Wei-Yen), Fernanda Lima-Costa, M., Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Liu, J. (Jing), Lorbeer, R. (Roberto), Lotufo, P.A. (Paulo A), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Ma, J. (Jun), Machado-Coelho, G.L.L. (George L. L.), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D.J., Maire, B. (Bernard), Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K.M. (Kodavanti Mallikharjuna), Malyutina, S., Manios, Y., Mann, J.I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Markey, O. (Oonagh), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martin-Prevel, Y. (Yves), Martorell, R. (Reynaldo), Masoodi, S.R. (Shariq R.), Mathiesen, E.B. (Ellisiv), Matsha, T.E. (Tandi E.), Mazur, A. (Artur), Mbanya, J.C.N. (Jean Claude N.), McFarlane, S.R. (Shelly R.), McGarvey, S.T. (Stephen T.), McKee, M. (Martin), McLachlan, S. (Stela), McLean, R.M. (Rachael M.), McNulty, B.A. (Breige A.), Yusof, S.M. (Safiah Md), Mediene-Benchekor, S. (Sounnia), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A.M.B. (Ana Maria B.), Mensink, G.B.M. (Gert B. M.), Meshram, I.I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Michaelsen, K.F., Mikkel, K. (Kairit), Miller, J.C. (Jody C.), Miquel, J.F. (Juan Francisco), Jaime Miranda, J., Mišigoj-Durakovic, M. (Marjeta), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M.F.M. (Muhammad Fadhli Mohd), Molbo, D. (Drude), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Mondo, C.K. (Charles K.), Monterrubio, E.A. (Eric A.), Monyeki, K.D.K. 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(Davide), Nsour, M.A. (Mohannad Al), O’Reilly, D. (Dermot), Oh, K. (Kyungwon), Olayan, I.H. (Iman H.), Olinto, M.T.A. (Maria Teresa Anselmo), Oltarzewski, M. (Maciej), Omar, M.A. (Mohd A.), Onat, A. (Altan), Ordunez, P. (Pedro), Ortiz, A.P. (Ana P.), Osler, M. (Merete), Osmond, C. (Clive), Ostojic, S.M. (Sergej M.), Otero, J.A. (Johanna A.), Overvad, K. (Kim), Owusu-Dabo, E. (Ellis), Paccaud, F.M. (Fred Michel), Padez, C. (Cristina), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palli, D. (Domenico), Palloni, A. (Alberto), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W.R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pecin, I. (Ivan), Pednekar, M.S. (Mangesh S.), Peeters, P.H.M., Peixoto, S.V. (Sergio Viana), Peltonen, M. (Markku), Pereira, A. (A.), Pérez, C.M. (Cynthia M.), Peters, A., Petkeviciene, J. (Janina), Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, A. (Alberto), Pistelli, F. 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(Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Voutilainen, S. (Sari), Vrdoljak, A. (Ana), Vrijheid, M. (Martine), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W.N.W. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. (Ying), Goya Wannamethee, S., Wareham, N.J. (Nick), Weerasekera, D. (Deepa), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Widyahening, I.S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A.H. (Alet), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong, J.E. (Jyh Eiin), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C.W. (Frederick C.), Wu, J. (Jianfeng), Wu, S.L. (Shou Ling), Xu, H. (Haiquan), Xu, L. (Liang), Yamborisut, U. (Uruwan), Yan, W. (Weili), Yang, X. (Xiaoguang), Yardim, N. (Nazan), Ye, X. (Xingwang), Yiallouros, P.K. (P.), Yoshihara, A. (Akihiro), You, Q.S. (Qi Sheng), Younger-Coleman, N.O. (Novie O.), Yusoff, A.F. (Ahmad F.), Zainuddin, A.A. (Ahmad A.), Zambon, S. (Sabina), Zdrojewski, T. (T.), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingfeng), Zhou, M. (Ming), Zhu, D. (Dan), Zimmermann, E., and Cisneros, J.Z. (Julio Zuñiga)
Abstract: Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5-22.7) and 16.5 cm (13.3- 19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8- 144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
Published: 2016
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17. Trends in adult body-mass index in 200 countries from 1975 to 2014: A pooled analysis of 1698 population-based measurement studies with 19.2 million participants

Author: Di Cesare, M. (Mariachiara), Bentham, J. (James), Stevens, G.A. (Gretchen A.), Zhou, B. (Bin), Danaei, G. (Goodarz), Lu, Y. (Yuan), Bixby, H. (Honor), Cowan, M.J. (Melanie J.), Riley, L.M. (Leanne M.), Hajifathalian, K. (Kaveh), Fortunato, L. (Léa), Taddei, C. (Cristina), Bennett, J.E. (James E.), Ikeda, N. (Nayu), Khang, Y.-H. (Young-Ho), Kyobutungi, C. (Catherine), Laxmaiah, A. (Avula), Li, Y. (Yanping), Lin, H.-H. (Hsien-Ho), Miranda, J.J. (J. Jaime), Mostafa, A. (Aya), Turley, M.L. (Maria L.), Paciorek, C.J. (Christopher J.), Gunter, M. (Marc), Ezzati, M. (Majid), Abdeen, Z.A. (Ziad A.), Hamid, Z.A. (Zargar Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Aguilar-Salinas, C.A. (Carlos), Ahmadvand, A. (Alireza), Ahrens, W. (W.), Ali, M.M. (Mohamed M.), Alkerwi, A. (Ala'a), Alvarez-Pedrerol, M. (Mar), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L.B. (Lars Bo), Anderssen, S.A. (Sigmund A.), Andrade, D.S. (Dolores S.), Anjana, R.M. (Ranjit Mohan), Aounallah-Skhiri, H. (Hajer), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Arveiler, D. (Dominique), Assah, F.K. (Felix K.), Avdicová, M. (Mária), Azizi, J. (Joshan), Babu, B.V. (Bontha V.), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J.R. (José R.), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Barkat, A. (Amina), Barros, M.V. (Mauro V.), Bata, I. (Iqbal), Batieha, A.M. (Anwar M.), Batista, R.L. (Rosangela L.), Baur, L.A. (Louise A.), Beaglehole, R. (Robert), Romdhane, H.B. (Habiba Ben), Benet, M. (Mikhail), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S.K. (Santosh K.), Bhatti, Z. (Zaid), Bhutta, Z.A. (Zulfiqar A), Bi, H. (HongSheng), Bi, Y. (Yufang), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Blake, M. (Margaret), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boddy, L.M. (Lynne M.), Boehm, B.O. (Bernhard), Boeing, H. (Heiner), Boissonnet, C.P. (Carlos P.), Bongard, V. (Vanina), Bovet, P. (Pascal), Braeckman, L. (Lutgart), Bragt, M.C.E. (Marjolijn C.E.), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Brian, G.R. (Garry R.), Bruno, G. (Graziella), Bueno-De-Mesquita, H.B., Bugge, A. (Anna), Burns, C. (Con), De León, A.C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Cama, T. (Tilema), Cameron, C. (Christine), Camolas, J. (José), Can, G. (Günay), Cândido, A.P.C. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V.C. (Viviane C.), Carvalho, M.J. (Maria J.), Casanueva, F.F. (Felipe F.), Casas, J.P. (Juan Pablo), Caserta, C.A. (Carmelo A.), Castetbon, K., Chamukuttan, S. (Snehalatha), Chan, A.W. (Angelique W.), Chan, Q. (Queenie), Chaturvedi, H.K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, Y. (Yumi), Christensen, K. (Kaare), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F., Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Charles), Cooper, R. (Rachel), Coppinger, T.C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C.L. (Cora L.), Crujeiras, A.B. (Ana B.), D'Arrigo, G. (Graziella), D'Orsi, E. (Eleonora), Dallongeville, J., Damasceno, A. (Albertino), Damsgaard, C.T. (Camilla T.), Dankner, R. (Rachel), Dauchet, L. (Luc), De Backer, G. (Guy), De Bacquer, D. (Dirk), De Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A.D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Hélène), Delpeuch, F. (Francis), Dhana, K. (Klodian), Di Castelnuovo, A.F. (Augusto F.), Dias-Da-Costa, J.S. (Juvenal Soares), Diaz, A. (Alejandro), Djalalinia, S. (Shirin), Do, H.T.P. (Ha T.P.), Dobson, A.J. (Annette J.), Donfrancesco, C. (Chiara), Döring, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Egbagbe, E.E. (Eruke E.), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Elliott, P. (Paul), Engle-Stone, R. (Reina), Erasmus, R.T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), De La Peña, J.E. (Jorge Escobedo), Evans, A. (Alun), Faeh, D. (David), Fall, C.H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J.D. (Joseph D.), Fischer, K. (Krista), Flores, E.M. (Eric Monterubio), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Fortmann, S.P. (Stephen), Fouad, H.M. (Heba M.), Francis, D.K. (Damian K.), Do Carmo Franco, M. (Maria), Franco, O.H. (Oscar), Frontera, G. (Guillermo), Fuchs, F.D. (Flavio D.), Fuchs, S.C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gafencu, M. (Mihai), Gareta, D. (Dickman), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Geleijnse, J.M. (Marianne), Ghasemian, A. (Anoosheh), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Goldsmith, R.A. (Rebecca A.), Gross, M., Rivas, J.P.G. (Juan P. González), Gorbea, M.B. (Mariano Bonet), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dušan), Grajda, A. (Aneta), Grammatikopoulou, M.G. (Maria G.), Gregor, R.D. (Ronald D.), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Gu, D. (Dongfeng), Guan, O.P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A.L. (Andre L.), Gulliford, M.C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Guo, X.H. (Xiu H.), Guo, Y. (Yin), Gupta, P.C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Halkjær, J., Hardy, R., Kumar, R.H. (Rachakulla Hari), Hayes, A.J. (Alison J.), He, J. (Jiang), Hendriks, M.E. (Marleen), Cadena, L.H. (Leticia Hernandez), Heshmat, R. (Ramin), Hihtaniemi, I.T. (Ilpo Tapani), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Hu, Y. (Yonghua), Hussieni, A.S. (Abdullatif S.), Huu, C.N. (Chinh Nguyen), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (M. Mohsen), Ikram, M.A. (Arfan), Irazola, V. (Vilma), Islam, M. (Muhammad), Iwasaki, M. (Masanori), Jackson, R.T. (Rod T.), Jacobs, J.M. (Jeremy M.), Jafar, T.H. (Tazeen), Jamil, K.M. (Kazi M.), Jamrozik, K., Jasienska, G. (Grazyna), Jiang, C.Q. (Chao Qiang), Joffres, M. (Michel), Johansson, M. (Mattias), Jonas, J.B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Jureša, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kapantais, E. (Efthymios), Kasaeian, A. (Amir), Katz, J. (Joanne), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Keil, M. (Mark), Boker, L.K. (Lital Keinan), Kelishadi, R. (Roya), Kemper, H.H.C.G. (Han H.C.G.), Kengne, A.P. (Andre Pascal), Kersting, M. (Mathilde), Key, T. (Timothy), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khaw, K.-T. (Kay-Tee), Khouw, I.M.S.L. (Ilse M.S.L.), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Kiyohara, Y. (Yutaka), Klimont, J. (Jeannette), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kratzer, W. (Wolfgang), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H.S. (Herculina S.), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Kumar, R.K. (R. Krishna), Kusuma, Y.S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Laamiri, F.Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Laugsand, L.E. (Lars E.), Le Nguyen Bao, K. (Khanh), Le, T.D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehtimäki, T. (Terho), Lekhraj, R. (Rampal), León-Munoz, L.M. (Luz M.), Lim, W.-Y. (Wei-Yen), Lima-Costa, M.F. (M. Fernanda), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Liu, J. (Jing), Lorbeer, R. (Roberto), Lotufo, P.A. (Paulo A), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D.J., Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K.M. (Kodavanti Mallikharjuna), Manios, Y., Mann, J.I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Markey, O. (Oonagh), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martin-Prevel, Y. (Yves), Martorell, R. (Reynaldo), Masoodi, S.R. (Shariq R.), Matsha, T.E. (Tandi E.), Mazur, A. (Artur), Mbanya, J.C.N. (Jean Claude N.), McFarlane, S.R. (Shelly R.), McGarvey, S.T. (Stephen T.), McKee, M. (Martin), McLachlan, S. (Stela), McLean, R.M. (Rachael M.), McNulty, B.A. (Breige A.), Md Yusof, S. (Safiah), Mediene-Benchekor, S. (Sounnia), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Mendes, L.L. (Larissa L.), Menezes, A.M.B. (Ana Maria B.), Mensink, G.B.M. (Gert B.M.), Meshram, I.I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Michaelsen, K.F., Mikkel, K. (Kairit), Miller, J.C. (Jody C.), Miquel, J.F. (Juan Francisco), Mišigoj-Duraković, M. (Marjeta), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M.F.M. (Muhammad Fadhli Mohd), Molbo, D. (Drude), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Mondo, C.K. (Charles K.), Monterrubio, E.A. (Eric A.), Monyeki, K.D.K. (Kotsedi Daniel K.), Moreira, L.B. (Leila B.), Morejon, A. (Alain), Moreno, L.A. (Luis A.), Morgan, K. (Karen), Mortensen, E.L. (Erik Lykke), Moschonis, G., Mossakowska, M. (Malgorzata), Mota, J. (Jorge), Motlagh, M.E. (Mohammad Esmaeel), Motta, J. (Jorge), Mu, T.T. (Thet Thet), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Murtagh, E.M. (Elaine M.), Musa, K.I. (Kamarul Imran), Musil, V. (Vera), Nagel, G. (Gabriele), Nakamura, H. (Harunobu), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, M. (Monika), Nankap, M. (Martin), Narake, S. (Sameer), Navarrete-Muñoz, E.M., Nenko, I. (Ilona), Neovius, M. (Martin), Nervi, F. (Flavio), Neuhauser, H.K. (Hannelore K.), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Norat, T. (Teresa), Noto, D. (Davide), Al Nsour, M. (Mohannad), O'Reilly, D. (Dermot), Ochoa-Avilés, A.M. (Angélica M.), Oh, K. (Kyungwon), Olayan, I.H. (Iman H.), Olinto, M.T.A. (Maria Teresa Anselmo), Oltarzewski, M. (Maciej), Omar, M.A. (Mohd A.), Onat, A. (Altan), Ordunez, P. (Pedro), Ortiz, A.P. (Ana P.), Osler, M. (Merete), Osmond, C. (Clive), Ostojic, S.M. (Sergej M.), Otero, J.A. (Johanna A.), Overvad, K. (Kim), Paccaud, F.M. (Fred Michel), Padez, C. (Cristina), Pajak, A. (Andrzej), Palli, D. (Domenico), Palloni, A. (Alberto), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W.R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pednekar, M.S. (Mangesh S.), Peeters, P.H.M., Peixoto, S.V. (Sergio Viana), Pereira, A. (A.), Pérez, C.M. (Cynthia M.), Peters, A., Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, A. (Alberto), Pistelli, F. (Francesco), Pitakaka, F. (Freda), Piwonska, A. (Aleksandra), Piwonski, J. (Jerzy), Plans-Rubió, P. (Pedro), Poh, B.K. (Bee Koon), Porta, M., Portegies, M.L.P. (Marileen), Poulimeneas, D. (Dimitrios), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J.F. (Jackie F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R.F. (Radwan F.), Qorbani, M. (Mostafa), Bao, T.Q. (Tran Quoc), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M. (Mahmudur), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S.R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramke, J. (Jacqueline), Ramos, R. (Rafel), Rampal, S. (Sanjay), Rasmussen, F. (Finn), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), De Wit, T.F.R. (Tobias Floris Rinke), Ritti-Dias, R.M. (Raphael M.), Rivera, J.A. (Juan A.), Robinson, S.M. (Siân), Robitaille, C. (Cynthia), Rodríguez Artalejo, F. (Fernando), Del Cristo Rodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rojroongwasinkul, N. (Nipa), Romaguera, D. (Dora), Ronkainen, K. (Kimmo), Rosengren, A. (Annika), Rouse, I. (Ian), Rubinstein, A. (Adolfo), Rühli, F.J. (Frank J.), Rui, O. (Ornelas), Ruiz-Betancourt, B.S. (Blanca Sandra), Horimoto, A.R.V.R. (Andrea R.V. Russo), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Saidi, O. (Olfa), Salanave, B. (Benoit), Martinez, E.S. (Eduardo Salazar), Salomaa, V. (Veikko), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Sandjaja, Sans, S. (Susana), Santos, D.A. (Diana A.), Santos, O. (Osvaldo), Dos Santos, R.N. (Renata Nunes), Santos, R. (Rute), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S., Scazufca, M. (Marcia), Rosario, A.S. (Angelika Schaffrath), Schargrodsky, H. (Herman), Schienkiewitz, A. (Anja), Schmidt, I.M. (Ida Maria), Schneider, I.J.C. (Ione J C), Schultsz, C. (Constance), Schutte, A.E. (Aletta E.), Sein, A.A. (Aye Aye), Sen, A. (Abhijit), Senbanjo, I.O. (Idowu O.), Sepanlou, S.G. (Sadaf G), Shalnova, S.A. (Svetlana A.), Shaw, J.E., Shibuya, K. (Kenji), Shin, Y. (Youchan), Shiri, R. (Rahman), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Silva, A.M. (Antonio M.), Silva, D.A.S. (Diego Augusto Santos), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon A.), Sjostrom, M. (Michael), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Smith, M.C. (Margaret C.), Snijder, M.B. (Marieke), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugène), Söderberg, S. (Stefan), Soekatri, M.Y.E. (Moesijanti Y.E.), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Sørensen, T.I.A. (Thorkild), Sorić, M. (Maroje), Jérome, C.S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J.A. (Jan), Starc, G. (Gregor), Stathopoulou, M.G. (Maria G.), Staub, K. (Kaspar), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stergiou, G.S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stöckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stratton, G. (Gareth), Strufaldi, M.W. (Maria Wany), Sun, C.-A. (Chien-An), Sundström, J. (Johan), Sung, Y.-T. (Yn-Tz), Sunyer, J. (Jordi), Suriyawongpaisal, P. (Paibul), Swinburn, B.A. (Boyd A.), Sy, R.G. (Rody G.), Szponar, L. (Lucjan), Tai, E.S. (E. Shyong), Tammesoo, M.L., Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M. (Mohammed), Tarp, J. (Jakob), Tarqui-Mamani, C.B. (Carolina B.), Taylor, A. (Anne), Tchibindat, F. (Félicité), Thijs, L. (Lutgarde), Thuesen, L. (Leif), Tjønneland, A. (Anne), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne S.), Topbas, M. (Murat), Topór-Madry, R. (Roman), Torrent, M. (Maties), Traissac, P. (Pierre), Trichopoulou, A. (Antonia), Trichopoulos, D. (Dimitrios), Trinh, O.T.H. (Oanh T.H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Tynelius, P. (Per), Tzotzas, T. (Themistoklis), Tzourio, C. (Christophe), Ueda, P. (Peter), Ukoli, F.A.M. (Flora A.M.), Ulmer, H. (Hanno), Unal, B. (Belgin), Valdivia, G. (Gonzalo), Vale, S. (Susana), Valvi, D. (Damaskini), Schouw, Y.T. (Yvonne) van der, Van Herck, K. (Koen), Van Minh, H. (Hoang), Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Monique Verschuren, W.M., Viegi, G., Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Voutilainen, S. (Sari), Vrijheid, M. (Martine), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W.N.W. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. (Ying), Wannamethee, S.G. (Goya), Wareham, N.J. (Nick), Weerasekera, D. (Deepa), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Widyahening, I.S. (Indah S.), Wiecek, A. (Andrzej), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Wojtyniak, B. (Bogdan), Wong, J.E. (Jyh Eiin), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C. (Frederick C.), Wu, J. (JianFeng), Wu, S.L. (Shou Ling), Xu, H. (Haiquan), Xu, L. (Liang), Yamborisut, U. (Uruwan), Yan, W. (Weili), Yang, X. (Xiaoguang), Yardim, N. (Nazan), Ye, X. (Xingwang), Yiallouros, P.K. (P.), Yoshihara, A. (Akihiro), You, Q.S. (Qi Sheng), Younger-Coleman, N.O. (Novie O.), Yusoff, A.F. (Ahmad F.), Zainuddin, A.A. (Ahmad A.), Zambon, S. (Sabina), Zdrojewski, T. (T.), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingfeng), Zhou, M. (Ming), Zhu, D. (Dan), Zimmermann, E., Cisneros, J.Z. (Julio Zuñiga), Di Cesare, M. (Mariachiara), Bentham, J. (James), Stevens, G.A. (Gretchen A.), Zhou, B. (Bin), Danaei, G. (Goodarz), Lu, Y. (Yuan), Bixby, H. (Honor), Cowan, M.J. (Melanie J.), Riley, L.M. (Leanne M.), Hajifathalian, K. (Kaveh), Fortunato, L. (Léa), Taddei, C. (Cristina), Bennett, J.E. (James E.), Ikeda, N. (Nayu), Khang, Y.-H. (Young-Ho), Kyobutungi, C. (Catherine), Laxmaiah, A. (Avula), Li, Y. (Yanping), Lin, H.-H. (Hsien-Ho), Miranda, J.J. (J. Jaime), Mostafa, A. (Aya), Turley, M.L. (Maria L.), Paciorek, C.J. (Christopher J.), Gunter, M. (Marc), Ezzati, M. (Majid), Abdeen, Z.A. (Ziad A.), Hamid, Z.A. (Zargar Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Aguilar-Salinas, C.A. (Carlos), Ahmadvand, A. (Alireza), Ahrens, W. (W.), Ali, M.M. (Mohamed M.), Alkerwi, A. (Ala'a), Alvarez-Pedrerol, M. (Mar), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L.B. (Lars Bo), Anderssen, S.A. (Sigmund A.), Andrade, D.S. (Dolores S.), Anjana, R.M. (Ranjit Mohan), Aounallah-Skhiri, H. (Hajer), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Arveiler, D. (Dominique), Assah, F.K. (Felix K.), Avdicová, M. (Mária), Azizi, J. (Joshan), Babu, B.V. (Bontha V.), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J.R. (José R.), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Barkat, A. (Amina), Barros, M.V. (Mauro V.), Bata, I. (Iqbal), Batieha, A.M. (Anwar M.), Batista, R.L. (Rosangela L.), Baur, L.A. (Louise A.), Beaglehole, R. (Robert), Romdhane, H.B. (Habiba Ben), Benet, M. (Mikhail), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S.K. (Santosh K.), Bhatti, Z. (Zaid), Bhutta, Z.A. (Zulfiqar A), Bi, H. (HongSheng), Bi, Y. (Yufang), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Blake, M. (Margaret), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boddy, L.M. (Lynne M.), Boehm, B.O. (Bernhard), Boeing, H. (Heiner), Boissonnet, C.P. (Carlos P.), Bongard, V. (Vanina), Bovet, P. (Pascal), Braeckman, L. (Lutgart), Bragt, M.C.E. (Marjolijn C.E.), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Brian, G.R. (Garry R.), Bruno, G. (Graziella), Bueno-De-Mesquita, H.B., Bugge, A. (Anna), Burns, C. (Con), De León, A.C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Cama, T. (Tilema), Cameron, C. (Christine), Camolas, J. (José), Can, G. (Günay), Cândido, A.P.C. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V.C. (Viviane C.), Carvalho, M.J. (Maria J.), Casanueva, F.F. (Felipe F.), Casas, J.P. (Juan Pablo), Caserta, C.A. (Carmelo A.), Castetbon, K., Chamukuttan, S. (Snehalatha), Chan, A.W. (Angelique W.), Chan, Q. (Queenie), Chaturvedi, H.K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, Y. (Yumi), Christensen, K. (Kaare), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F., Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Charles), Cooper, R. (Rachel), Coppinger, T.C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C.L. (Cora L.), Crujeiras, A.B. (Ana B.), D'Arrigo, G. (Graziella), D'Orsi, E. (Eleonora), Dallongeville, J., Damasceno, A. (Albertino), Damsgaard, C.T. (Camilla T.), Dankner, R. (Rachel), Dauchet, L. (Luc), De Backer, G. (Guy), De Bacquer, D. (Dirk), De Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A.D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Hélène), Delpeuch, F. (Francis), Dhana, K. (Klodian), Di Castelnuovo, A.F. (Augusto F.), Dias-Da-Costa, J.S. (Juvenal Soares), Diaz, A. (Alejandro), Djalalinia, S. (Shirin), Do, H.T.P. (Ha T.P.), Dobson, A.J. (Annette J.), Donfrancesco, C. (Chiara), Döring, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Egbagbe, E.E. (Eruke E.), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Elliott, P. (Paul), Engle-Stone, R. (Reina), Erasmus, R.T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), De La Peña, J.E. (Jorge Escobedo), Evans, A. (Alun), Faeh, D. (David), Fall, C.H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J.D. (Joseph D.), Fischer, K. (Krista), Flores, E.M. (Eric Monterubio), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Fortmann, S.P. (Stephen), Fouad, H.M. (Heba M.), Francis, D.K. (Damian K.), Do Carmo Franco, M. (Maria), Franco, O.H. (Oscar), Frontera, G. (Guillermo), Fuchs, F.D. (Flavio D.), Fuchs, S.C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gafencu, M. (Mihai), Gareta, D. (Dickman), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Geleijnse, J.M. (Marianne), Ghasemian, A. (Anoosheh), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Goldsmith, R.A. (Rebecca A.), Gross, M., Rivas, J.P.G. (Juan P. González), Gorbea, M.B. (Mariano Bonet), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dušan), Grajda, A. (Aneta), Grammatikopoulou, M.G. (Maria G.), Gregor, R.D. (Ronald D.), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Gu, D. (Dongfeng), Guan, O.P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A.L. (Andre L.), Gulliford, M.C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Guo, X.H. (Xiu H.), Guo, Y. (Yin), Gupta, P.C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Halkjær, J., Hardy, R., Kumar, R.H. (Rachakulla Hari), Hayes, A.J. (Alison J.), He, J. (Jiang), Hendriks, M.E. (Marleen), Cadena, L.H. (Leticia Hernandez), Heshmat, R. (Ramin), Hihtaniemi, I.T. (Ilpo Tapani), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Hu, Y. (Yonghua), Hussieni, A.S. (Abdullatif S.), Huu, C.N. (Chinh Nguyen), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (M. Mohsen), Ikram, M.A. (Arfan), Irazola, V. (Vilma), Islam, M. (Muhammad), Iwasaki, M. (Masanori), Jackson, R.T. (Rod T.), Jacobs, J.M. (Jeremy M.), Jafar, T.H. (Tazeen), Jamil, K.M. (Kazi M.), Jamrozik, K., Jasienska, G. (Grazyna), Jiang, C.Q. (Chao Qiang), Joffres, M. (Michel), Johansson, M. (Mattias), Jonas, J.B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Jureša, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kapantais, E. (Efthymios), Kasaeian, A. (Amir), Katz, J. (Joanne), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Keil, M. (Mark), Boker, L.K. (Lital Keinan), Kelishadi, R. (Roya), Kemper, H.H.C.G. (Han H.C.G.), Kengne, A.P. (Andre Pascal), Kersting, M. (Mathilde), Key, T. (Timothy), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khaw, K.-T. (Kay-Tee), Khouw, I.M.S.L. (Ilse M.S.L.), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Kiyohara, Y. (Yutaka), Klimont, J. (Jeannette), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kratzer, W. (Wolfgang), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H.S. (Herculina S.), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Kumar, R.K. (R. Krishna), Kusuma, Y.S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Laamiri, F.Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Laugsand, L.E. (Lars E.), Le Nguyen Bao, K. (Khanh), Le, T.D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehtimäki, T. (Terho), Lekhraj, R. (Rampal), León-Munoz, L.M. (Luz M.), Lim, W.-Y. (Wei-Yen), Lima-Costa, M.F. (M. Fernanda), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Liu, J. (Jing), Lorbeer, R. (Roberto), Lotufo, P.A. (Paulo A), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D.J., Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K.M. (Kodavanti Mallikharjuna), Manios, Y., Mann, J.I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Markey, O. (Oonagh), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martin-Prevel, Y. (Yves), Martorell, R. (Reynaldo), Masoodi, S.R. (Shariq R.), Matsha, T.E. (Tandi E.), Mazur, A. (Artur), Mbanya, J.C.N. (Jean Claude N.), McFarlane, S.R. (Shelly R.), McGarvey, S.T. (Stephen T.), McKee, M. (Martin), McLachlan, S. (Stela), McLean, R.M. (Rachael M.), McNulty, B.A. (Breige A.), Md Yusof, S. (Safiah), Mediene-Benchekor, S. (Sounnia), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Mendes, L.L. (Larissa L.), Menezes, A.M.B. (Ana Maria B.), Mensink, G.B.M. (Gert B.M.), Meshram, I.I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Michaelsen, K.F., Mikkel, K. (Kairit), Miller, J.C. (Jody C.), Miquel, J.F. (Juan Francisco), Mišigoj-Duraković, M. (Marjeta), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M.F.M. (Muhammad Fadhli Mohd), Molbo, D. (Drude), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Mondo, C.K. (Charles K.), Monterrubio, E.A. (Eric A.), Monyeki, K.D.K. (Kotsedi Daniel K.), Moreira, L.B. (Leila B.), Morejon, A. (Alain), Moreno, L.A. (Luis A.), Morgan, K. (Karen), Mortensen, E.L. (Erik Lykke), Moschonis, G., Mossakowska, M. (Malgorzata), Mota, J. (Jorge), Motlagh, M.E. (Mohammad Esmaeel), Motta, J. (Jorge), Mu, T.T. (Thet Thet), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Murtagh, E.M. (Elaine M.), Musa, K.I. (Kamarul Imran), Musil, V. (Vera), Nagel, G. (Gabriele), Nakamura, H. (Harunobu), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, M. (Monika), Nankap, M. (Martin), Narake, S. (Sameer), Navarrete-Muñoz, E.M., Nenko, I. (Ilona), Neovius, M. (Martin), Nervi, F. (Flavio), Neuhauser, H.K. (Hannelore K.), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Norat, T. (Teresa), Noto, D. (Davide), Al Nsour, M. (Mohannad), O'Reilly, D. (Dermot), Ochoa-Avilés, A.M. (Angélica M.), Oh, K. (Kyungwon), Olayan, I.H. (Iman H.), Olinto, M.T.A. (Maria Teresa Anselmo), Oltarzewski, M. (Maciej), Omar, M.A. (Mohd A.), Onat, A. (Altan), Ordunez, P. (Pedro), Ortiz, A.P. (Ana P.), Osler, M. (Merete), Osmond, C. (Clive), Ostojic, S.M. (Sergej M.), Otero, J.A. (Johanna A.), Overvad, K. (Kim), Paccaud, F.M. (Fred Michel), Padez, C. (Cristina), Pajak, A. (Andrzej), Palli, D. (Domenico), Palloni, A. (Alberto), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W.R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pednekar, M.S. (Mangesh S.), Peeters, P.H.M., Peixoto, S.V. (Sergio Viana), Pereira, A. (A.), Pérez, C.M. (Cynthia M.), Peters, A., Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, A. (Alberto), Pistelli, F. (Francesco), Pitakaka, F. (Freda), Piwonska, A. (Aleksandra), Piwonski, J. (Jerzy), Plans-Rubió, P. (Pedro), Poh, B.K. (Bee Koon), Porta, M., Portegies, M.L.P. (Marileen), Poulimeneas, D. (Dimitrios), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J.F. (Jackie F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R.F. (Radwan F.), Qorbani, M. (Mostafa), Bao, T.Q. (Tran Quoc), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M. (Mahmudur), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S.R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramke, J. (Jacqueline), Ramos, R. (Rafel), Rampal, S. (Sanjay), Rasmussen, F. (Finn), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), De Wit, T.F.R. (Tobias Floris Rinke), Ritti-Dias, R.M. (Raphael M.), Rivera, J.A. (Juan A.), Robinson, S.M. (Siân), Robitaille, C. (Cynthia), Rodríguez Artalejo, F. (Fernando), Del Cristo Rodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rojroongwasinkul, N. (Nipa), Romaguera, D. (Dora), Ronkainen, K. (Kimmo), Rosengren, A. (Annika), Rouse, I. (Ian), Rubinstein, A. (Adolfo), Rühli, F.J. (Frank J.), Rui, O. (Ornelas), Ruiz-Betancourt, B.S. (Blanca Sandra), Horimoto, A.R.V.R. (Andrea R.V. Russo), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Saidi, O. (Olfa), Salanave, B. (Benoit), Martinez, E.S. (Eduardo Salazar), Salomaa, V. (Veikko), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Sandjaja, Sans, S. (Susana), Santos, D.A. (Diana A.), Santos, O. (Osvaldo), Dos Santos, R.N. (Renata Nunes), Santos, R. (Rute), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S., Scazufca, M. (Marcia), Rosario, A.S. (Angelika Schaffrath), Schargrodsky, H. (Herman), Schienkiewitz, A. (Anja), Schmidt, I.M. (Ida Maria), Schneider, I.J.C. (Ione J C), Schultsz, C. (Constance), Schutte, A.E. (Aletta E.), Sein, A.A. (Aye Aye), Sen, A. (Abhijit), Senbanjo, I.O. (Idowu O.), Sepanlou, S.G. (Sadaf G), Shalnova, S.A. (Svetlana A.), Shaw, J.E., Shibuya, K. (Kenji), Shin, Y. (Youchan), Shiri, R. (Rahman), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Silva, A.M. (Antonio M.), Silva, D.A.S. (Diego Augusto Santos), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon A.), Sjostrom, M. (Michael), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Smith, M.C. (Margaret C.), Snijder, M.B. (Marieke), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugène), Söderberg, S. (Stefan), Soekatri, M.Y.E. (Moesijanti Y.E.), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Sørensen, T.I.A. (Thorkild), Sorić, M. (Maroje), Jérome, C.S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J.A. (Jan), Starc, G. (Gregor), Stathopoulou, M.G. (Maria G.), Staub, K. (Kaspar), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stergiou, G.S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stöckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stratton, G. (Gareth), Strufaldi, M.W. (Maria Wany), Sun, C.-A. (Chien-An), Sundström, J. (Johan), Sung, Y.-T. (Yn-Tz), Sunyer, J. (Jordi), Suriyawongpaisal, P. (Paibul), Swinburn, B.A. (Boyd A.), Sy, R.G. (Rody G.), Szponar, L. (Lucjan), Tai, E.S. (E. Shyong), Tammesoo, M.L., Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M. (Mohammed), Tarp, J. (Jakob), Tarqui-Mamani, C.B. (Carolina B.), Taylor, A. (Anne), Tchibindat, F. (Félicité), Thijs, L. (Lutgarde), Thuesen, L. (Leif), Tjønneland, A. (Anne), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne S.), Topbas, M. (Murat), Topór-Madry, R. (Roman), Torrent, M. (Maties), Traissac, P. (Pierre), Trichopoulou, A. (Antonia), Trichopoulos, D. (Dimitrios), Trinh, O.T.H. (Oanh T.H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Tynelius, P. (Per), Tzotzas, T. (Themistoklis), Tzourio, C. (Christophe), Ueda, P. (Peter), Ukoli, F.A.M. (Flora A.M.), Ulmer, H. (Hanno), Unal, B. (Belgin), Valdivia, G. (Gonzalo), Vale, S. (Susana), Valvi, D. (Damaskini), Schouw, Y.T. (Yvonne) van der, Van Herck, K. (Koen), Van Minh, H. (Hoang), Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Monique Verschuren, W.M., Viegi, G., Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Voutilainen, S. (Sari), Vrijheid, M. (Martine), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W.N.W. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. (Ying), Wannamethee, S.G. (Goya), Wareham, N.J. (Nick), Weerasekera, D. (Deepa), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Widyahening, I.S. (Indah S.), Wiecek, A. (Andrzej), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Wojtyniak, B. (Bogdan), Wong, J.E. (Jyh Eiin), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C. (Frederick C.), Wu, J. (JianFeng), Wu, S.L. (Shou Ling), Xu, H. (Haiquan), Xu, L. (Liang), Yamborisut, U. (Uruwan), Yan, W. (Weili), Yang, X. (Xiaoguang), Yardim, N. (Nazan), Ye, X. (Xingwang), Yiallouros, P.K. (P.), Yoshihara, A. (Akihiro), You, Q.S. (Qi Sheng), Younger-Coleman, N.O. (Novie O.), Yusoff, A.F. (Ahmad F.), Zainuddin, A.A. (Ahmad A.), Zambon, S. (Sabina), Zdrojewski, T. (T.), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingfeng), Zhou, M. (Ming), Zhu, D. (Dan), Zimmermann, E., and Cisneros, J.Z. (Julio Zuñiga)
Abstract: Copyright
Published: 2016
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18. Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease

Author: De Guio, F. (François), Jouvent, E. (Eric), Biessels, G.J. (Geert Jan), Black, S.E. (Sandra), Brayne, C. (Carol), Chen, C. (Christopher), Cordonnier, C. (Charlotte), Leeuw, H.F. (Frank) de, Kubisch, C. (Christian), Doubal, F. (Fergus), Duering, M. (Marco), Dufouil, C. (Carole), Duzel, E. (Emrah), Fazekas, F. (Franz), Hachinski, V. (Vladimir), Ikram, M.K. (Kamran), Linn, J. (Jennifer), Matthews, P.M. (P.), Mazoyer, B. (Bernard), Mok, V. (Vincent), Norrving, B. (Bo), O'Brien, J.T. (John T.), Pantoni, L. (Leonardo), Ropele, S. (Stefan), Sachdev, P.S. (Perminder), Schmidt, R. (Reinhold), Seshadri, S. (Sudha), Smith, E.E. (Eric), Sposato, L.A. (Luciano A), Stephan, B.C.M., Swartz, R.H. (Richard H.), Tzourio, C. (Christophe), Buchem, M.A. (Mark) van, Lugt, A. (Aad) van der, Oostenbrugge, R.J. (Robert) van, Vernooij, M.W. (Meike), Viswanathan, A. (Anand), Werring, D.J. (David), Wollenweber, F. (Frank), Wardlaw, J.M. (J.), Chabriat, H. (Hugues), De Guio, F. (François), Jouvent, E. (Eric), Biessels, G.J. (Geert Jan), Black, S.E. (Sandra), Brayne, C. (Carol), Chen, C. (Christopher), Cordonnier, C. (Charlotte), Leeuw, H.F. (Frank) de, Kubisch, C. (Christian), Doubal, F. (Fergus), Duering, M. (Marco), Dufouil, C. (Carole), Duzel, E. (Emrah), Fazekas, F. (Franz), Hachinski, V. (Vladimir), Ikram, M.K. (Kamran), Linn, J. (Jennifer), Matthews, P.M. (P.), Mazoyer, B. (Bernard), Mok, V. (Vincent), Norrving, B. (Bo), O'Brien, J.T. (John T.), Pantoni, L. (Leonardo), Ropele, S. (Stefan), Sachdev, P.S. (Perminder), Schmidt, R. (Reinhold), Seshadri, S. (Sudha), Smith, E.E. (Eric), Sposato, L.A. (Luciano A), Stephan, B.C.M., Swartz, R.H. (Richard H.), Tzourio, C. (Christophe), Buchem, M.A. (Mark) van, Lugt, A. (Aad) van der, Oostenbrugge, R.J. (Robert) van, Vernooij, M.W. (Meike), Viswanathan, A. (Anand), Werring, D.J. (David), Wollenweber, F. (Frank), Wardlaw, J.M. (J.), and Chabriat, H. (Hugues)
Abstract: Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on magnetic resonance imaging including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and brain volume. The aim is to summarize, for each marker, what is currently known about: (1) its reproducibility in studies with a scan-rescan procedure either in single or multicenter settings; (2) the acquisition-related sources of variability; and, (3) the techniques used to minimize this variability. Based on the results, we discuss technical and other challenges that need to be overcome in order for these markers to be reliably used as outcome measures in future clinical trials. We also highlight the key points that need to be considered when designing multicenter magnetic resonance imaging studies of small vessel disease.
Published: 2016
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19. White Matter Lesion Progression: Genome-Wide Search for Genetic Influences

Author: Hofer, E. (Edith), Cavalieri, M. (Margherita), Bis, J.C. (Joshua), DeCarli, C. (Charles), Fornage, M. (Myriam), Sigurdsson, S. (Sigurdur), Srikanth, V. (Velandai), Trompet, S. (Stella), Verhaaren, B.F.J. (Benjamin), Wolf, C. (Christiane), Yang, Q. (Qiong Fang), Adams, H.H.H. (Hieab), Amouyel, P. (Philippe), Beiser, A. (Alexa), Buckley, B.M. (Brendan M.), Callisaya, M. (Michele), Chauhan, G. (Ganesh), De Craen, A.J.M. (Anton J. M.), Dufouil, C. (Carole), Duijn, C.M. (Cornelia) van, Ford, I., Freudenberger, P. (Paul), Gottesman, R.F. (Rebecca), Gudnason, V. (Vilmundur), Heiss, G. (Gerardo), Hofman, A. (Albert), Lumley, T. (Thomas), Martinez, O. (Oliver), Mazoyer, B. (Bernard), Moran, C. (Chris), Niessen, W.J. (Wiro), Phan, T.G. (Thanh), Psaty, B.M. (Bruce), Satizabal, C.L. (Claudia), Sattar, N. (Naveed), Schilling, S. (Sabrina), Shibata, D.K. (Dean), Slagboom, P.E. (Eline), Smith, A.V. (Davey), Stott, D.J. (David. J.), Taylor, K.D. (Kent), Thomson, R. (Russell), Töglhofer, A.M. (Anna Maria), Tzourio, C. (Christophe), Buchem, M.A. (Mark) van, Wang, J. (Jing), Westendorp, R.G.J. (Rudi), Windham, B.G. (Gwen), Vernooij, M.W. (Meike), Zijdenbos, A.P., Beare, R.J. (Richard), Debette, S. (Stéphanie), Ikram, M.A. (Arfan), Jukema, J.W. (Jan Wouter), Launer, L.J. (Lenore), Longstreth Jr, W.T., Mosley, T.H. (Thomas H.), Seshadri, S. (Sudha), Schmidt, R. (Reinhold), Hofer, E. (Edith), Cavalieri, M. (Margherita), Bis, J.C. (Joshua), DeCarli, C. (Charles), Fornage, M. (Myriam), Sigurdsson, S. (Sigurdur), Srikanth, V. (Velandai), Trompet, S. (Stella), Verhaaren, B.F.J. (Benjamin), Wolf, C. (Christiane), Yang, Q. (Qiong Fang), Adams, H.H.H. (Hieab), Amouyel, P. (Philippe), Beiser, A. (Alexa), Buckley, B.M. (Brendan M.), Callisaya, M. (Michele), Chauhan, G. (Ganesh), De Craen, A.J.M. (Anton J. M.), Dufouil, C. (Carole), Duijn, C.M. (Cornelia) van, Ford, I., Freudenberger, P. (Paul), Gottesman, R.F. (Rebecca), Gudnason, V. (Vilmundur), Heiss, G. (Gerardo), Hofman, A. (Albert), Lumley, T. (Thomas), Martinez, O. (Oliver), Mazoyer, B. (Bernard), Moran, C. (Chris), Niessen, W.J. (Wiro), Phan, T.G. (Thanh), Psaty, B.M. (Bruce), Satizabal, C.L. (Claudia), Sattar, N. (Naveed), Schilling, S. (Sabrina), Shibata, D.K. (Dean), Slagboom, P.E. (Eline), Smith, A.V. (Davey), Stott, D.J. (David. J.), Taylor, K.D. (Kent), Thomson, R. (Russell), Töglhofer, A.M. (Anna Maria), Tzourio, C. (Christophe), Buchem, M.A. (Mark) van, Wang, J. (Jing), Westendorp, R.G.J. (Rudi), Windham, B.G. (Gwen), Vernooij, M.W. (Meike), Zijdenbos, A.P., Beare, R.J. (Richard), Debette, S. (Stéphanie), Ikram, M.A. (Arfan), Jukema, J.W. (Jan Wouter), Launer, L.J. (Lenore), Longstreth Jr, W.T., Mosley, T.H. (Thomas H.), Seshadri, S. (Sudha), and Schmidt, R. (Reinhold)
Abstract: Background and Purpose-White matter lesion (WML) progression on magnetic resonance imaging is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants associated with WML progression in elderly participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Methods-Heritability of WML progression was calculated in the Framingham Heart Study. The genome-wide association study included 7773 elderly participants from 10 cohorts. To assess the relative contribution of genetic factors to progression of WML, we compared in 7 cohorts risk models including demographics, vascular risk factors plus single-nucleotide polymorphisms that have been shown to be associated cross-sectionally with WML in the current and previous association studies. Results-A total of 1085 subjects showed WML progression. The heritability estimate for WML progression was low at 6.5%, and no single-nucleotide polymorphisms achieved genome-wide significance (P<5×10-8). Four loci were suggestive (P<1×10-5) of an association with WML progression: 10q24.32 (rs10883817, P=1.46×10-6); 12q13.13 (rs4
Published: 2015
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20. Genome-wide studies of verbal declarative memory in nondemented older people: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

Author: Debette, S. (Stéphanie), Ibrahim-Verbaas, C.A. (Carla), Bressler, J. (Jan), Schuur, M. (Maaike), Smith, A.V. (Davey), Bis, J.C. (Joshua), Davies, G. (Gail), Wolf, C. (Christiane), Gudnason, V. (Vilmundur), Chibnik, L.B. (Lori), Yang, Q. (Qiong Fang), DeStefano, A.L. (Anita), De Quervain, D.J.F. (Dominique J.F.), Srikanth, V. (Velandai), Lahti, J. (Jari), Grabe, H.J. (Hans Jörgen), Smith, J.A. (Jennifer A), Priebe, L., Yu, L. (Lei), Karbalai, N. (Nazanin), Hayward, C. (Caroline), Wilson, J.F. (James F), Campbell, H. (Harry), Petrovic, K. (Katja), Fornage, M. (Myriam), Chauhan, G. (Ganesh), Yeo, R. (Robin), Boxall, R. (Ruth), Becker, J.T. (James), Stegle, O. (Oliver), Mather, R., Chouraki, V. (Vincent), Sun, Q. (Qi), Rose, L.M. (Lynda), Resnick, S.M. (Susan), Oldmeadow, C. (Christopher), Kirin, M. (Mirna), Wright, A. (Alan), Jonsdottir, M.K. (Maria K.), Au, R. (Rhoda), Becker, A. (Albert), Amin, N. (Najaf), Nalls, M.A. (Michael), Turner, S.T. (Stephen), Kardia, S.L.R. (Sharon), Oostra, B.A. (Ben), Windham, G. (Gwen), Coker, L.H. (Laura), Zhao, W. (Wei), Knopman, D.S. (David), Heiss, G. (Gerardo), Griswold, M.D. (Michael), Gottesman, R.F. (Rebecca), Vitart, V. (Veronique), Hastie, N. (Nick), Zgaga, L. (Lina), Rudan, I. (Igor), Polasek, O. (Ozren), Holliday, E.G. (Elizabeth), Schofield, P. (Peter), Choi, S.-H. (Seung-Hoan), Tanaka, T. (Toshiko), An, Y. (Yang), Perry, R.T. (Rodney T.), Kennedy, R.E. (Richard E.), Sale, M.M. (Michèle M.), Wang, J. (Jing), Wadley, V.G. (Virginia G.), Liewald, D.C. (David C.), Ridker, P.M. (Paul), Gow, A.J. (Alan J.), Pattie, A. (Alison), Starr, J.M. (John), Porteous, D.J. (David J.), Liu, X. (Xuan), Thomson, R. (Russell), Armstrong, N.J. (Nicola), Eiriksdottir, G. (Gudny), Assareh, A.A. (Arezoo), Kochan, N.A. (Nicole A.), Widen, E. (Elisabeth), Palotie, A. (Aarno), Hsieh, Y.-C. (Yi-Chen), Eriksson, J.G. (Johan G.), Vogler, C. (Christian), Swieten, J.C. (John) van, Shulman, L. (Lee), Beiser, A. (Alexa), Rotter, J.I. (Jerome I.), Schmidt, C.O. (Carsten O.), Hoffmann, W. (Wolfgang), Nöthen, M.M. (Markus M.), Ferrucci, L. (Luigi), Attia, J. (John), Uitterlinden, A.G. (André), Amouyel, P. (Philippe), Dartigues, J.-F. (Jean-François), Amieva, H. (Hélène), Räikkönen, K. (Katri), Garcia, M. (Melissa), Wolf, P.A. (Philip), Hofman, A. (Albert), Longstreth Jr, W.T., Psaty, B.M. (Bruce), Boerwinkle, E.A. (Eric), DeJager, P.L. (Philip L.), Sachdev, P.S. (Perminder), Schmidt, R. (Reinhold), Breteler, M.M.B. (Monique), Teumer, A. (Alexander), Lopez, O.L. (Oscar), Cichon, S. (Sven), Chasman, D.I. (Daniel), Grodstein, F. (Francine), Müller-Myhsok, B. (B.), Tzourio, C. (Christophe), Papassotiropoulos, A. (Andreas), Bennett, D.A. (David), Ikram, M.A. (Arfan), Deary, I.J. (Ian), Duijn, C.M. (Cornelia) van, Launer, L.J. (Lenore), Fitzpatrick, A.L. (Annette), Seshadri, S. (Sudha), Mosley, T.H. (Thomas H.), Debette, S. (Stéphanie), Ibrahim-Verbaas, C.A. (Carla), Bressler, J. (Jan), Schuur, M. (Maaike), Smith, A.V. (Davey), Bis, J.C. (Joshua), Davies, G. (Gail), Wolf, C. (Christiane), Gudnason, V. (Vilmundur), Chibnik, L.B. (Lori), Yang, Q. (Qiong Fang), DeStefano, A.L. (Anita), De Quervain, D.J.F. (Dominique J.F.), Srikanth, V. (Velandai), Lahti, J. (Jari), Grabe, H.J. (Hans Jörgen), Smith, J.A. (Jennifer A), Priebe, L., Yu, L. (Lei), Karbalai, N. (Nazanin), Hayward, C. (Caroline), Wilson, J.F. (James F), Campbell, H. (Harry), Petrovic, K. (Katja), Fornage, M. (Myriam), Chauhan, G. (Ganesh), Yeo, R. (Robin), Boxall, R. (Ruth), Becker, J.T. (James), Stegle, O. (Oliver), Mather, R., Chouraki, V. (Vincent), Sun, Q. (Qi), Rose, L.M. (Lynda), Resnick, S.M. (Susan), Oldmeadow, C. (Christopher), Kirin, M. (Mirna), Wright, A. (Alan), Jonsdottir, M.K. (Maria K.), Au, R. (Rhoda), Becker, A. (Albert), Amin, N. (Najaf), Nalls, M.A. (Michael), Turner, S.T. (Stephen), Kardia, S.L.R. (Sharon), Oostra, B.A. (Ben), Windham, G. (Gwen), Coker, L.H. (Laura), Zhao, W. (Wei), Knopman, D.S. (David), Heiss, G. (Gerardo), Griswold, M.D. (Michael), Gottesman, R.F. (Rebecca), Vitart, V. (Veronique), Hastie, N. (Nick), Zgaga, L. (Lina), Rudan, I. (Igor), Polasek, O. (Ozren), Holliday, E.G. (Elizabeth), Schofield, P. (Peter), Choi, S.-H. (Seung-Hoan), Tanaka, T. (Toshiko), An, Y. (Yang), Perry, R.T. (Rodney T.), Kennedy, R.E. (Richard E.), Sale, M.M. (Michèle M.), Wang, J. (Jing), Wadley, V.G. (Virginia G.), Liewald, D.C. (David C.), Ridker, P.M. (Paul), Gow, A.J. (Alan J.), Pattie, A. (Alison), Starr, J.M. (John), Porteous, D.J. (David J.), Liu, X. (Xuan), Thomson, R. (Russell), Armstrong, N.J. (Nicola), Eiriksdottir, G. (Gudny), Assareh, A.A. (Arezoo), Kochan, N.A. (Nicole A.), Widen, E. (Elisabeth), Palotie, A. (Aarno), Hsieh, Y.-C. (Yi-Chen), Eriksson, J.G. (Johan G.), Vogler, C. (Christian), Swieten, J.C. (John) van, Shulman, L. (Lee), Beiser, A. (Alexa), Rotter, J.I. (Jerome I.), Schmidt, C.O. (Carsten O.), Hoffmann, W. (Wolfgang), Nöthen, M.M. (Markus M.), Ferrucci, L. (Luigi), Attia, J. (John), Uitterlinden, A.G. (André), Amouyel, P. (Philippe), Dartigues, J.-F. (Jean-François), Amieva, H. (Hélène), Räikkönen, K. (Katri), Garcia, M. (Melissa), Wolf, P.A. (Philip), Hofman, A. (Albert), Longstreth Jr, W.T., Psaty, B.M. (Bruce), Boerwinkle, E.A. (Eric), DeJager, P.L. (Philip L.), Sachdev, P.S. (Perminder), Schmidt, R. (Reinhold), Breteler, M.M.B. (Monique), Teumer, A. (Alexander), Lopez, O.L. (Oscar), Cichon, S. (Sven), Chasman, D.I. (Daniel), Grodstein, F. (Francine), Müller-Myhsok, B. (B.), Tzourio, C. (Christophe), Papassotiropoulos, A. (Andreas), Bennett, D.A. (David), Ikram, M.A. (Arfan), Deary, I.J. (Ian), Duijn, C.M. (Cornelia) van, Launer, L.J. (Lenore), Fitzpatrick, A.L. (Annette), Seshadri, S. (Sudha), and Mosley, T.H. (Thomas H.)
Abstract: BACKGROUND: Memory performance in older persons can reflect genetic influences on cognitive function and dementing processes. We aimed to identify genetic contributions to verbal declarative memory in a community setting. MET
Published: 2015
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21. Association of Alzheimer's disease GWAS loci with MRI markers of brain aging

Author: Chauhan, G. (Ganesh), Adams, H.H.H. (Hieab), Bis, J.C. (Joshua), Weinstein, G. (Galit), Yu, L. (Lei), Töglhofer, A.M. (Anna Maria), Smith, A.V. (Davey), Lee, S.J. (Sven) van der, Gottesman, R.F. (Rebecca), Thomson, R. (Russell), Wang, J. (Jing), Yang, Q. (Qiong Fang), Niessen, W.J. (Wiro), Lopez, O.L. (Oscar), Becker, J.T. (James), Phan, T.G. (Thanh), Beare, R.J. (Richard), Arfanakis, K. (Konstantinos), Fleischman, D. (Debra), Vernooij, M.W. (Meike), Mazoyer, B. (Bernard), Schmidt, R. (Reinhold), Srikanth, V. (Velandai), Knopman, D.S. (David), Jack Jr., C.R. (Clifford), Amouyel, P. (Philippe), Hofman, A. (Albert), DeCarli, C. (Charles), Tzourio, C. (Christophe), Duijn, C.M. (Cornelia) van, Bennett, D.A. (David), Longstreth Jr, W.T., Mosley, T.H. (Thomas H.), Fornage, M. (Myriam), Launer, L.J. (Lenore), Seshadri, S. (Sudha), Ikram, M.A. (Arfan), Debette, S. (Stéphanie), Chauhan, G. (Ganesh), Adams, H.H.H. (Hieab), Bis, J.C. (Joshua), Weinstein, G. (Galit), Yu, L. (Lei), Töglhofer, A.M. (Anna Maria), Smith, A.V. (Davey), Lee, S.J. (Sven) van der, Gottesman, R.F. (Rebecca), Thomson, R. (Russell), Wang, J. (Jing), Yang, Q. (Qiong Fang), Niessen, W.J. (Wiro), Lopez, O.L. (Oscar), Becker, J.T. (James), Phan, T.G. (Thanh), Beare, R.J. (Richard), Arfanakis, K. (Konstantinos), Fleischman, D. (Debra), Vernooij, M.W. (Meike), Mazoyer, B. (Bernard), Schmidt, R. (Reinhold), Srikanth, V. (Velandai), Knopman, D.S. (David), Jack Jr., C.R. (Clifford), Amouyel, P. (Philippe), Hofman, A. (Albert), DeCarli, C. (Charles), Tzourio, C. (Christophe), Duijn, C.M. (Cornelia) van, Bennett, D.A. (David), Longstreth Jr, W.T., Mosley, T.H. (Thomas H.), Fornage, M. (Myriam), Launer, L.J. (Lenore), Seshadri, S. (Sudha), Ikram, M.A. (Arfan), and Debette, S. (Stéphanie)
Abstract: Whether novel risk variants of Alzheimer's disease (AD) identified through genome-wide association studies also influence magnetic resonance imaging-based intermediate phenotypes of AD in the general population is unclear. We studied association of 24 AD risk loci with intracranial volume, total brain volume, hippocampal volume (HV), white matter hyperintensity burden, and brain infarcts in a meta-analysis of genetic association studies from large population-based samples (N= 8175-11,550). In single-SNP based tests, AD risk allele of APOE (rs2075650) was associated with smaller HV (. p= 0.0054) and CD33 (rs3865444) with smaller intracranial volume (. p= 0.0058). In gene-based tests, there was associations of HLA-DRB1 with total brain volume (. p= 0.0006) and BIN1 with HV (. p= 0.00089). Aweighted AD genetic risk score was associated with smaller HV (beta ± SE=-0.047 ± 0.013, p= 0.00041), even after excluding the APOE locus (. p= 0.029). However, only association of AD genetic risk score with HV, including APOE, was significant after multiple testing correction (including number of independent phenotypes tested). These results suggest that novel AD genetic risk variants may contribute to structural brain aging in nondemented older community persons.
Published: 2015
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22. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

Author: Escott-Price, V. (Valentina), Bellenguez, C. (Céline), Wang, L.S. (Li-San), Choi, S.-H. (Seung-Hoan), Harold, D. (Denise), Jones, L. (Louisa), Holmans, P.A. (Peter), Gerrish, A. (Amy), Vedernikov, A. (Alexey), Richards, A. (Alex), DeStefano, A.L. (Anita), Lambert, J.-C. (J.), Ibrahim-Verbaas, C.A. (Carla), Naj, A.C. (Adam), Sims, R. (Rebecca), Jun, Y. (Yang), Bis, J.C. (Joshua), Beecham, G.W. (Gary), Grenier-Boley, B. (Benjamin), Russo, G. (Giancarlo), Thornton-Wells, T.A. (Tricia), Denning, N. (Nicola), Smith, A.V. (Davey), Chouraki, V. (Vincent), Thomas, C. (Charlene), Ikram, M.A. (Arfan), Zelenika, D. (Diana), Vardarajan, B.N. (Badri), Kamatani, Y. (Yoichiro), Lin, C.-F. (Chiao-Feng), Schmidt, R. (Reinhold), Kunkle, B. (Brian), Dunstan, M.L. (Melanie), Vronskaya, M. (Maria), Johnson, A.D. (Andrew), Ruiz, A. (Agustin), Bihoreau, M.-T. (Marie-Thérèse), Reitz, C. (Christiane), Pasquier, F. (Florence), Hollingworth, P. (Paul), Hanon, O. (Olivier), Fitzpatrick, A.L. (Annette), Buxbaum, J.D. (Joseph D), Campion, D. (Dominique), Crane, L.M.A., Becker, C.B.T. (Clinton), Gudnason, V. (Vilmundur), Cruchaga, C. (Carlos), Craig, D. (David), Amin, N. (Najaf), Berr, C. (Claudine), Lopez, O.L. (Oscar), Jager, P.L. (Philip) de, Deramecourt, V. (Vincent), Johnston, J.A. (Janet), Evans, D.A. (Denis), Lovestone, S. (Simon), Letenneur, L., Hernández, I. (Isabel), Rubinsztein, D.C. (David), Eiriksdottir, G. (Gudny), Sleegers, K. (Kristel), Goate, A.M. (Alison), Fiévet, N. (Nathalie), Huentelman, M.J. (Matthew), Gill, M. (Michael), Brown, K. (Kristelle), Kamboh, M.I. (M. Ilyas), Keller, L. (Lina), Barberger-Gateau, P. (Pascale), McGuinness, B. (Bernadette), Larson, E.B. (Eric), Myers, A.J. (Amanda), Dufouil, C. (Carole), Todd, S. (Stephen), Wallon, D. (David), Love, S. (Seth), Rogaeva, E. (Ekaterina), Gallacher, J. (John), St George-Hyslop, P.H. (Peter), Clarimon, J. (Jordi), Lleo, A. (Alberto), Bayer, T. (T.), Tsuang, D.W. (Debby), Yu, L. (Lei), Tsolaki, M. (Magda), Bossù, P. (Paola), Spalletta, G. (Gianfranco), Proitsi, P. (Petroula), Collinge, J. (John), Sorbi, S. (Sandro), Sanchez Garcia, F. (Florentino), Fox, N.C. (Nick), Hardy, J. (John), Naranjo, A. (Antonio), Bosco, P. (Paolo), Clarke, R. (Robert), Brayne, C. (Carol), Galimberti, D. (Daniela), Scarpini, E. (Elio), Bonuccelli, U. (Ubaldo), Mancuso, M. (Michelangelo), Siciliano, G. (Gabriele), Moebus, S. (Susanne), Mecocci, P. (Patrizia), Zompo, M.D. (Maria) del, Maier, W. (Wolfgang), Hampel, H. (Harald), Pilotto, A. (Alberto), Frank-Garcia, A. (Ana), Panza, F. (Francesco), Solfrizzi, V. (Vincenzo), Caffarra, P. (Paolo), Nacmias, B. (Benedetta), Perry, W. (William), Mayhaus, M. (Manuel), Lannfelt, L. (Lars), Hakonarson, H. (Hakon), Pichler, I. (Irene), Carrasquillo, M.M. (Minerva), Ingelsson, M. (Martin), Beekly, D. (Duane), Alvarez, V. (Victoria), Zou, F. (Fanggeng), Valladares, O. (Otto), Younkin, S., Coto, E. (Eliecer), Hamilton-Nelson, K.L. (Kara), Gu, W. (Wei), Razquin, C. (Cristina), Pastor, P. (Pau), Mateo, I. (Ignacio), Owen, M.J. (Michael), Faber, K.M. (Kelley), Jonsson, P.V. (Palmi), Combarros, O. (Onofre), O'Donovan, M. (Michael), Cantwell, L.B. (Laura), Soininen, H. (Hilkka), Blacker, D. (Deborah), Mead, S. (Simon), Mosley, T.H. (Thomas), Bennett, D.A. (David), Harris, T.B. (Tamara), Fratiglioni, L. (Laura), Holmes, C. (Clive), Bruijn, R.F.A.G. (Renée) de, Passmore, P.A. (Peter), Montine, T.J. (Thomas), Bettens, K. (Karolien), Rotter, J.I. (Jerome), Brice, A., Morgan, K. (Kevin), Foroud, T. (Tatiana), Kukull, W.A., Hannequin, D. (Didier), Powell, J. (John), Nalls, M.A. (Michael), Ritchie, K. (Karen), Lunetta, K.L. (Kathryn), Kauwe, J.S.K. (John), Boerwinkle, E.A. (Eric), Riemenschneider, M. (Matthias), Boada, M. (Mercè), Hiltunen, M. (Mikko), Martin, E.R. (Eden), Rujescu, D. (Dan), Dartigues, J.-F., Mayeux, R. (Richard), Tzourio, C. (Christophe), Hofman, A. (Albert), Nöthen, M.M. (Markus), Graff, M.J. (Maud J.L.), Psaty, B.M. (Bruce), Haines, J.L. (Jonathan), Lathrop, M. (Mark), Pericak-Vance, M.A. (Margaret), Launer, L.J. (Lenore), Broeckhoven, C. (Christine) van, Farrer, L.A. (Lindsay), Duijn, C.M. (Cornelia) van, Ramirez, A. (Alfredo), Seshadri, S. (Sudha), Schellenberg, G.D. (Gerard), Amouyel, P. (Philippe), Williams, J. (Julie), Escott-Price, V. (Valentina), Bellenguez, C. (Céline), Wang, L.S. (Li-San), Choi, S.-H. (Seung-Hoan), Harold, D. (Denise), Jones, L. (Louisa), Holmans, P.A. (Peter), Gerrish, A. (Amy), Vedernikov, A. (Alexey), Richards, A. (Alex), DeStefano, A.L. (Anita), Lambert, J.-C. (J.), Ibrahim-Verbaas, C.A. (Carla), Naj, A.C. (Adam), Sims, R. (Rebecca), Jun, Y. (Yang), Bis, J.C. (Joshua), Beecham, G.W. (Gary), Grenier-Boley, B. (Benjamin), Russo, G. (Giancarlo), Thornton-Wells, T.A. (Tricia), Denning, N. (Nicola), Smith, A.V. (Davey), Chouraki, V. (Vincent), Thomas, C. (Charlene), Ikram, M.A. (Arfan), Zelenika, D. (Diana), Vardarajan, B.N. (Badri), Kamatani, Y. (Yoichiro), Lin, C.-F. (Chiao-Feng), Schmidt, R. (Reinhold), Kunkle, B. (Brian), Dunstan, M.L. (Melanie), Vronskaya, M. (Maria), Johnson, A.D. (Andrew), Ruiz, A. (Agustin), Bihoreau, M.-T. (Marie-Thérèse), Reitz, C. (Christiane), Pasquier, F. (Florence), Hollingworth, P. (Paul), Hanon, O. (Olivier), Fitzpatrick, A.L. (Annette), Buxbaum, J.D. (Joseph D), Campion, D. (Dominique), Crane, L.M.A., Becker, C.B.T. (Clinton), Gudnason, V. (Vilmundur), Cruchaga, C. (Carlos), Craig, D. (David), Amin, N. (Najaf), Berr, C. (Claudine), Lopez, O.L. (Oscar), Jager, P.L. (Philip) de, Deramecourt, V. (Vincent), Johnston, J.A. (Janet), Evans, D.A. (Denis), Lovestone, S. (Simon), Letenneur, L., Hernández, I. (Isabel), Rubinsztein, D.C. (David), Eiriksdottir, G. (Gudny), Sleegers, K. (Kristel), Goate, A.M. (Alison), Fiévet, N. (Nathalie), Huentelman, M.J. (Matthew), Gill, M. (Michael), Brown, K. (Kristelle), Kamboh, M.I. (M. Ilyas), Keller, L. (Lina), Barberger-Gateau, P. (Pascale), McGuinness, B. (Bernadette), Larson, E.B. (Eric), Myers, A.J. (Amanda), Dufouil, C. (Carole), Todd, S. (Stephen), Wallon, D. (David), Love, S. (Seth), Rogaeva, E. (Ekaterina), Gallacher, J. (John), St George-Hyslop, P.H. (Peter), Clarimon, J. (Jordi), Lleo, A. (Alberto), Bayer, T. (T.), Tsuang, D.W. (Debby), Yu, L. (Lei), Tsolaki, M. (Magda), Bossù, P. (Paola), Spalletta, G. (Gianfranco), Proitsi, P. (Petroula), Collinge, J. (John), Sorbi, S. (Sandro), Sanchez Garcia, F. (Florentino), Fox, N.C. (Nick), Hardy, J. (John), Naranjo, A. (Antonio), Bosco, P. (Paolo), Clarke, R. (Robert), Brayne, C. (Carol), Galimberti, D. (Daniela), Scarpini, E. (Elio), Bonuccelli, U. (Ubaldo), Mancuso, M. (Michelangelo), Siciliano, G. (Gabriele), Moebus, S. (Susanne), Mecocci, P. (Patrizia), Zompo, M.D. (Maria) del, Maier, W. (Wolfgang), Hampel, H. (Harald), Pilotto, A. (Alberto), Frank-Garcia, A. (Ana), Panza, F. (Francesco), Solfrizzi, V. (Vincenzo), Caffarra, P. (Paolo), Nacmias, B. (Benedetta), Perry, W. (William), Mayhaus, M. (Manuel), Lannfelt, L. (Lars), Hakonarson, H. (Hakon), Pichler, I. (Irene), Carrasquillo, M.M. (Minerva), Ingelsson, M. (Martin), Beekly, D. (Duane), Alvarez, V. (Victoria), Zou, F. (Fanggeng), Valladares, O. (Otto), Younkin, S., Coto, E. (Eliecer), Hamilton-Nelson, K.L. (Kara), Gu, W. (Wei), Razquin, C. (Cristina), Pastor, P. (Pau), Mateo, I. (Ignacio), Owen, M.J. (Michael), Faber, K.M. (Kelley), Jonsson, P.V. (Palmi), Combarros, O. (Onofre), O'Donovan, M. (Michael), Cantwell, L.B. (Laura), Soininen, H. (Hilkka), Blacker, D. (Deborah), Mead, S. (Simon), Mosley, T.H. (Thomas), Bennett, D.A. (David), Harris, T.B. (Tamara), Fratiglioni, L. (Laura), Holmes, C. (Clive), Bruijn, R.F.A.G. (Renée) de, Passmore, P.A. (Peter), Montine, T.J. (Thomas), Bettens, K. (Karolien), Rotter, J.I. (Jerome), Brice, A., Morgan, K. (Kevin), Foroud, T. (Tatiana), Kukull, W.A., Hannequin, D. (Didier), Powell, J. (John), Nalls, M.A. (Michael), Ritchie, K. (Karen), Lunetta, K.L. (Kathryn), Kauwe, J.S.K. (John), Boerwinkle, E.A. (Eric), Riemenschneider, M. (Matthias), Boada, M. (Mercè), Hiltunen, M. (Mikko), Martin, E.R. (Eden), Rujescu, D. (Dan), Dartigues, J.-F., Mayeux, R. (Richard), Tzourio, C. (Christophe), Hofman, A. (Albert), Nöthen, M.M. (Markus), Graff, M.J. (Maud J.L.), Psaty, B.M. (Bruce), Haines, J.L. (Jonathan), Lathrop, M. (Mark), Pericak-Vance, M.A. (Margaret), Launer, L.J. (Lenore), Broeckhoven, C. (Christine) van, Farrer, L.A. (Lindsay), Duijn, C.M. (Cornelia) van, Ramirez, A. (Alfredo), Seshadri, S. (Sudha), Schellenberg, G.D. (Gerard), Amouyel, P. (Philippe), and Williams, J. (Julie)
Published: 2014
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23. The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism

Author: Klebe, S. (Stephan), Golmard, L. (Lisa), Nalls, M.A. (Michael), Saad, F. (Fred), Singleton, A. (Andrew), Bras, J. (Jose), Hardy, J. (John), Simón-Sánchez, J. (Javier), Heutink, P. (Peter), Kuhlenbäumer, G. (Gregor), Charfi, R. (Rim), Klein, C. (Christoph), Hagenah, J., Gasser, T. (Thomas), Wurster, K.D. (Kathrin), Lesage, S. (Suzanne), Lorenz, D. (Delia), Deuschl, G. (Günther), Durif, F. (Franck), Pollak, M.N. (Michael), Damier, P. (Philippe), Tison, F. (François), Durr, A., Amouyel, P. (Philippe), Lambert, J.C. (Jean Charles), Tzourio, C. (Christophe), Maubaret, C. (Cécilia), Charbonnier-Beaupel, F. (Fanny), Tahiri, K. (Khadija), Vidailhet, M. (M.), Martinez, M. (Maria), Brice, A., Corvol, J.C. (Jean-Christophe), Agid, Y. (Yves), Anheim, M. (M.), Bonnet, A.-M. (A.), Borg, M. (Michael), Broussolle, E. (E.), Corvol, J.C. (Jean Christophe), Damier, Ph. (Ph), Destée, A. (A.), Durif, F. (F.), Klebe, S. (S.), Lohmann, E. (E.), Penet, C. (C.), Krack, P. (P.), Rascol, O. (O.), Tison, F. (F.), Tranchant, C. (C.), Vérin, M. (M.), Viallet, F. (F.), Vidailhet, M. (Marie), Plagnol, V. (Vincent), Bras, J.M. (Jose), Hernandez, D.G. (Dena), Sharma, M., Sheerin, U.-M. (Una-Marie), Schulte, C. (Claudia), Sveinbjörnsdóttir, S. (Sigurlaug), Arepalli, S. (Sampath), Band, G. (Gavin), Vukcevic, D. (Damjan), Barker, R.A. (Roger), Bellinguez, C. (Céline), Ben-Shlomo, Y., Berendse, H.W. (Henk W.), Berg, D. (Daniela), Bhatia, K.P. (Kailash), Bie, R.M.A. (Rob) de, Biffi, A. (Alessandro), Bloem, B. (Bas), Bochdanovits, Z. (Zoltan), Bonin, M. (Malte) von, Brockmann, K., Brooks, J. (Janet), Burn, D.J. (David), Charlesworth, K. (Kate), Chen, H. (Honglei), Chinnery, P.F. (Patrick), Chong, S. (Sean), Clarke, C.E. (Carl), Cookson, M.R. (Mark), Cooper, J.M. (J. Mark), Counsell, C. (Carl), Dartigues, J.-F., Deloukas, P. (Panagiotis), Dexter, D.T. (David), Dijk, K.D. (Karin) van, Dillman, A. (Allissa), Durif, F. (Frank), Edkins, T. (Ted), Evans, J. (Jonathan Mark), Foltynie, T. (Thomas), Freeman, C. (Colin), Gao, J. (Jianjun), Gardner, M. (Mac), Gibbs, J. (Raphael), Goate, A.M. (Alison), Gray, E. (Emma), Guerreiro, R. (Rita), Gustafsson, O. (Omar), Harris, C. (Clare), Hellenthal, F.A., Hilten, J.J. (Jacobus) van, Hofman, A. (Albert), Hollenbeck, J.R. (John R.), Holton, J.L. (Janice), Hu, M. (Michele), Huang, X. (Xiaohong), Huber, H. (Heiko), Hudson, G. (Gavin), Hunt, S.E. (Sarah), Huttenlocher, J. (Johanna), Illig, T. (Thomas), Jónsson, P.V. (Pálmi), Langford, C. (Cordelia), Lees, A.J. (Andrew), Lichtner, P. (Peter), Limousin, P. (Patricia), Lopez, G., McNeill, N.H. (Nathan), Moorby, C. (Catriona), Moore, M. (Matt), Morris, H. (Huw), Morrison, K.E. (Karen), Mudanohwo, E. (Ese), O'Sullivan, S.S. (Sean), Pearson, J. (Justin), Pearson, R. (Ruth), Perlmutter, J.S. (Joel), Pétursson, H. (Hjörvar), Pirinen, M. (Matti), Post, B. (Bart), Ravina, B. (Bernard), Revesz, T. (Tamas), Riess, O. (Olaf), Rivadeneira Ramirez, F. (Fernando), Rizzu, P. (Patrizia), Ryten, M. (Mina), Sawcer, S.J. (Stephen), Schapira, A.H.V. (Anthony), Scheffer, H. (Hans), Shaw, K. (Karen), Shoulson, I. (Ira), Sidransky, E. (Ellen), Silva, R. (Rohan) de, Smith, C. (Colin), Spencer, C.C.A. (Chris C.), Stefansson, H. (Hreinn), Wolf, C. (Christiane), Stockton, J.D. (Joanna), Strange, A. (Amy), Su, Z. (Zhan), Talbot, D., Tanner, C.M. (Carlie), Tashakkori-Ghanbaria, A. (Avazeh), Trabzuni, D. (Danyah), Traynor, B.J. (Bryan), Uitterlinden, A.G. (André), Vandrovcova, J. (Jana), Velseboer, D. (Daan), Walker, R. (Robert), Warrenburg, B. (Bart) van de, Weale, M.E. (Michael), Wickremaratchi, M. (Mirdhu), Williams, N. (Nigel), Williams-Gray, C.H. (Caroline), Winder-Rhodes, S. (Sophie), Zwart, J-A. (John-Anker), Wood, N.W. (Nicholas), Klebe, S. (Stephan), Golmard, L. (Lisa), Nalls, M.A. (Michael), Saad, F. (Fred), Singleton, A. (Andrew), Bras, J. (Jose), Hardy, J. (John), Simón-Sánchez, J. (Javier), Heutink, P. (Peter), Kuhlenbäumer, G. (Gregor), Charfi, R. (Rim), Klein, C. (Christoph), Hagenah, J., Gasser, T. (Thomas), Wurster, K.D. (Kathrin), Lesage, S. (Suzanne), Lorenz, D. (Delia), Deuschl, G. (Günther), Durif, F. (Franck), Pollak, M.N. (Michael), Damier, P. (Philippe), Tison, F. (François), Durr, A., Amouyel, P. (Philippe), Lambert, J.C. (Jean Charles), Tzourio, C. (Christophe), Maubaret, C. (Cécilia), Charbonnier-Beaupel, F. (Fanny), Tahiri, K. (Khadija), Vidailhet, M. (M.), Martinez, M. (Maria), Brice, A., Corvol, J.C. (Jean-Christophe), Agid, Y. (Yves), Anheim, M. (M.), Bonnet, A.-M. (A.), Borg, M. (Michael), Broussolle, E. (E.), Corvol, J.C. (Jean Christophe), Damier, Ph. (Ph), Destée, A. (A.), Durif, F. (F.), Klebe, S. (S.), Lohmann, E. (E.), Penet, C. (C.), Krack, P. (P.), Rascol, O. (O.), Tison, F. (F.), Tranchant, C. (C.), Vérin, M. (M.), Viallet, F. (F.), Vidailhet, M. (Marie), Plagnol, V. (Vincent), Bras, J.M. (Jose), Hernandez, D.G. (Dena), Sharma, M., Sheerin, U.-M. (Una-Marie), Schulte, C. (Claudia), Sveinbjörnsdóttir, S. (Sigurlaug), Arepalli, S. (Sampath), Band, G. (Gavin), Vukcevic, D. (Damjan), Barker, R.A. (Roger), Bellinguez, C. (Céline), Ben-Shlomo, Y., Berendse, H.W. (Henk W.), Berg, D. (Daniela), Bhatia, K.P. (Kailash), Bie, R.M.A. (Rob) de, Biffi, A. (Alessandro), Bloem, B. (Bas), Bochdanovits, Z. (Zoltan), Bonin, M. (Malte) von, Brockmann, K., Brooks, J. (Janet), Burn, D.J. (David), Charlesworth, K. (Kate), Chen, H. (Honglei), Chinnery, P.F. (Patrick), Chong, S. (Sean), Clarke, C.E. (Carl), Cookson, M.R. (Mark), Cooper, J.M. (J. Mark), Counsell, C. (Carl), Dartigues, J.-F., Deloukas, P. (Panagiotis), Dexter, D.T. (David), Dijk, K.D. (Karin) van, Dillman, A. (Allissa), Durif, F. (Frank), Edkins, T. (Ted), Evans, J. (Jonathan Mark), Foltynie, T. (Thomas), Freeman, C. (Colin), Gao, J. (Jianjun), Gardner, M. (Mac), Gibbs, J. (Raphael), Goate, A.M. (Alison), Gray, E. (Emma), Guerreiro, R. (Rita), Gustafsson, O. (Omar), Harris, C. (Clare), Hellenthal, F.A., Hilten, J.J. (Jacobus) van, Hofman, A. (Albert), Hollenbeck, J.R. (John R.), Holton, J.L. (Janice), Hu, M. (Michele), Huang, X. (Xiaohong), Huber, H. (Heiko), Hudson, G. (Gavin), Hunt, S.E. (Sarah), Huttenlocher, J. (Johanna), Illig, T. (Thomas), Jónsson, P.V. (Pálmi), Langford, C. (Cordelia), Lees, A.J. (Andrew), Lichtner, P. (Peter), Limousin, P. (Patricia), Lopez, G., McNeill, N.H. (Nathan), Moorby, C. (Catriona), Moore, M. (Matt), Morris, H. (Huw), Morrison, K.E. (Karen), Mudanohwo, E. (Ese), O'Sullivan, S.S. (Sean), Pearson, J. (Justin), Pearson, R. (Ruth), Perlmutter, J.S. (Joel), Pétursson, H. (Hjörvar), Pirinen, M. (Matti), Post, B. (Bart), Ravina, B. (Bernard), Revesz, T. (Tamas), Riess, O. (Olaf), Rivadeneira Ramirez, F. (Fernando), Rizzu, P. (Patrizia), Ryten, M. (Mina), Sawcer, S.J. (Stephen), Schapira, A.H.V. (Anthony), Scheffer, H. (Hans), Shaw, K. (Karen), Shoulson, I. (Ira), Sidransky, E. (Ellen), Silva, R. (Rohan) de, Smith, C. (Colin), Spencer, C.C.A. (Chris C.), Stefansson, H. (Hreinn), Wolf, C. (Christiane), Stockton, J.D. (Joanna), Strange, A. (Amy), Su, Z. (Zhan), Talbot, D., Tanner, C.M. (Carlie), Tashakkori-Ghanbaria, A. (Avazeh), Trabzuni, D. (Danyah), Traynor, B.J. (Bryan), Uitterlinden, A.G. (André), Vandrovcova, J. (Jana), Velseboer, D. (Daan), Walker, R. (Robert), Warrenburg, B. (Bart) van de, Weale, M.E. (Michael), Wickremaratchi, M. (Mirdhu), Williams, N. (Nigel), Williams-Gray, C.H. (Caroline), Winder-Rhodes, S. (Sophie), Zwart, J-A. (John-Anker), and Wood, N.W. (Nicholas)
Abstract: The catechol-O-methyltranferase (COMT) is one of the main enzymes that metabolise dopamine in the brain. The Val158Met polymorphism in the COMT gene (rs4680) causes a trimodal distribution of high (Val/Val), intermediate (Val/Met) and low (Met/Met) enzyme activity. We tested whether the Val158Met polymorphism is a modifier of the age at onset (AAO) in Parkinson’s disease (PD). The rs4680 was genotyped in a total of 16 609 subjects from five independent cohorts of European and North American origin (5886 patients with PD and 10 723 healthy controls). The multivariate analysis for comparing PD and control groups was based on a stepwise logistic regression, with gender, age and cohort origin included in the initial model. The multivariate analysis of the AAO was a mixed linear model, with COMT genotype and gender considered as fixed effects and cohort and cohort-gender interaction as random effects. COMT genotype was coded as a quantitative variable, assuming a codominant genetic effect. The distribution of the COMT polymorphism was not significantly different in patients and controls (p=0.22). The Val allele had a significant effect on the AAO with a younger AAO in patients with the Val/Val (57.1±13.9, p=0.03) than the Val/Met (57.4±13.9) and the Met/Met genotypes (58.3±13.5). The difference was greater in men (1.9 years between Val/Val and Met/Met, p=0.007) than in women (0.2 years, p=0.81). Thus, the Val158Met COMT polym
Published: 2013
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24. Genome-wide association studies of cerebral white matter lesion burden

Author: Fornage, M. (Myriam), Debette, S. (Stéphanie), Bis, J.C. (Joshua), Schmidt, R. (Reinhold), Ikram, M.A. (Arfan), Dufouil, C. (Carole), Sigurdsson, S. (Stefan), Lumley, T. (Thomas), DeStefano, A.L. (Anita), Fazekas, F. (Franz), Vrooman, H.A. (Henri), Shibata, D.K. (Dean), Maillard, P. (Pauline), Zijdenbos, A.P., Smith, A.V. (Albert Vernon), Gudnason, H. (Haukur), Boer, R. (Renske) de, Cushman, M. (Mary Ann), Mazoyer, B. (Bernard), Heiss, G. (Gerardo), Vernooij, M.W. (Meike), Enzinger, C. (Christian), Glazer, N.L. (Nicole), Beiser, A. (Alexa), Knopman, D.S. (David), Cavalieri, M. (Margherita), Niessen, W.J. (Wiro), Harris, T.B. (Tamara), Petrovic, K. (Katja), Lopez, O.L. (Oscar), Au, R. (Rhoda), Lambert, J.C. (Jean Charles), Hofman, A. (Albert), Gottesman, R.F. (Rebecca), Garcia, M. (Melissa), Heckbert, S.R. (Susan), Atwood, L.D. (Larry), Catellier, D.J. (Diane), Uitterlinden, A.G. (André), Yang, Q. (Qiong Fang), Aspelund, T. (Thor), Romero, J.R. (Jose Rafael), Rice, K. (Kenneth), Taylor, K.D. (Kent), Nalls, M.A. (Michael), Rotter, J.I. (Jerome), Sharrett, R. (Richey), Tikka-Kleemola, P. (Päivi), Amouyel, P. (Philippe), Wolf, P.A. (Philip), Lugt, A. (Aad) van der, Boerwinkle, E.A. (Eric), Psaty, B.M. (Bruce), Seshadri, S. (Sudha), Tzourio, C. (Christophe), Breteler, M.M.B. (Monique), Mosley, T.H. (Thomas), Longstreth Jr, W.T., DeCarli, C. (Charles), Launer, L.J. (Lenore), Fornage, M. (Myriam), Debette, S. (Stéphanie), Bis, J.C. (Joshua), Schmidt, R. (Reinhold), Ikram, M.A. (Arfan), Dufouil, C. (Carole), Sigurdsson, S. (Stefan), Lumley, T. (Thomas), DeStefano, A.L. (Anita), Fazekas, F. (Franz), Vrooman, H.A. (Henri), Shibata, D.K. (Dean), Maillard, P. (Pauline), Zijdenbos, A.P., Smith, A.V. (Albert Vernon), Gudnason, H. (Haukur), Boer, R. (Renske) de, Cushman, M. (Mary Ann), Mazoyer, B. (Bernard), Heiss, G. (Gerardo), Vernooij, M.W. (Meike), Enzinger, C. (Christian), Glazer, N.L. (Nicole), Beiser, A. (Alexa), Knopman, D.S. (David), Cavalieri, M. (Margherita), Niessen, W.J. (Wiro), Harris, T.B. (Tamara), Petrovic, K. (Katja), Lopez, O.L. (Oscar), Au, R. (Rhoda), Lambert, J.C. (Jean Charles), Hofman, A. (Albert), Gottesman, R.F. (Rebecca), Garcia, M. (Melissa), Heckbert, S.R. (Susan), Atwood, L.D. (Larry), Catellier, D.J. (Diane), Uitterlinden, A.G. (André), Yang, Q. (Qiong Fang), Aspelund, T. (Thor), Romero, J.R. (Jose Rafael), Rice, K. (Kenneth), Taylor, K.D. (Kent), Nalls, M.A. (Michael), Rotter, J.I. (Jerome), Sharrett, R. (Richey), Tikka-Kleemola, P. (Päivi), Amouyel, P. (Philippe), Wolf, P.A. (Philip), Lugt, A. (Aad) van der, Boerwinkle, E.A. (Eric), Psaty, B.M. (Bruce), Seshadri, S. (Sudha), Tzourio, C. (Christophe), Breteler, M.M.B. (Monique), Mosley, T.H. (Thomas), Longstreth Jr, W.T., DeCarli, C. (Charles), and Launer, L.J. (Lenore)
Abstract: Objective: White matter hyperintensities (WMHs) detectable by magnetic resonance imaging are part of the spectrum of vascular injury associated with aging of the brain and are thought to reflect ischemic damage to the small deep cerebral vessels. WMHs are associated with an increased risk of cognitive and motor dysfunction, dementia, depression, and stroke. Despite a significant heritability, few genetic loci influencing WMH burden have been identified. Methods: We performed a meta-analysis of genome-wide association studies (GWASs) for WMH burden in 9,361 stroke-free individuals of European descent from 7 community-based cohorts. Significant findings were tested for replication in 3,024 individuals from 2 additional cohorts. Results: We identified 6 novel risk-associated single nucleotide polymorphisms (SNPs) in 1 locus on chromosome 17q25 encompassing 6 known genes including WBP2, TRIM65, TRIM47, MRPL38, FBF1, and ACOX1. The most significant association was for rs3744028 (pdiscovery= 4.0 × 10-9; preplication= 1.3 × 10-7; pcombined= 4.0 × 10-15). Other SNPs i
Published: 2011
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25. Genome-wide analysis of genetic loci associated with Alzheimer disease

Author: Seshadri, S. (Sudha), Fitzpatrick, A.L. (Annette), Ikram, M.A. (Arfan), DeStefano, A.L. (Anita), Gudnason, V. (Vilmundur), Boada, M. (Merce), Bis, J.C. (Joshua), Smith, A.V. (Albert), Carassquillo, M.M. (Minerva M.), Lambert, J.-C. (J.), Harold, D. (Denise), Schrijvers, E.M.C. (Elisabeth M. C.), Ramírez-Lorca, R. (R.), Debette, S. (Stéphanie), Longstreth Jr, W.T., Janssens, A.C.J.W. (Cécile), Pankratz, V.S. (Shane), Dartigues, J.-F., Hollingworth, P. (Paul), Aspelund, T. (Thor), Hernández, I. (Isabel), Beiser, A. (Alexa), Kuller, L.H. (Lewis), Koudstaal, P.J. (Peter), Dickson, D. (Dennis), Tzourio, C. (Christophe), Abraham, R. (Richard), Antúnez, C. (C.), Du, Y. (Yangchun), Rotter, J.I. (Jerome I.), Aulchenko, Y.S. (Yurii), Harris, T.B. (Tamara), Petersen, R.C. (Ronald C.), Berr, C. (Claudine), Owen, M.J. (Michael), López-Arrieta, J. (J.), Vardarajan, B.N. (Badri), Becker, J.T. (James), Rivadeneira Ramirez, F. (Fernando), Nalls, M.A. (Michael), Graff-Radford, N.R. (Neill), Campion, D. (Dominique), Auerbach, S. (Sanford), Rice, K.M. (Kenneth), Hofman, A. (Albert), Jonsson, P.V. (Palmi V.), Schmidt, H. (Helena), Lathrop, M. (Mark), Mosley, T.H. (Thomas H.), Au, R. (Rhoda), Psaty, B.M. (Bruce), Uitterlinden, A.G. (André), Farrer, L.A. (Lindsay), Lumley, T. (Thomas), Ruiz, A. (A.), Williams, J. (Julie), Amouyel, P. (Philippe), Younkin, S., Wolf, P.A. (Philip A.), Launer, L.J. (Lenore), Lopez, O.L. (Oscar), Duijn, C.M. (Cornelia) van, Breteler, M.M.B. (Monique), Seshadri, S. (Sudha), Fitzpatrick, A.L. (Annette), Ikram, M.A. (Arfan), DeStefano, A.L. (Anita), Gudnason, V. (Vilmundur), Boada, M. (Merce), Bis, J.C. (Joshua), Smith, A.V. (Albert), Carassquillo, M.M. (Minerva M.), Lambert, J.-C. (J.), Harold, D. (Denise), Schrijvers, E.M.C. (Elisabeth M. C.), Ramírez-Lorca, R. (R.), Debette, S. (Stéphanie), Longstreth Jr, W.T., Janssens, A.C.J.W. (Cécile), Pankratz, V.S. (Shane), Dartigues, J.-F., Hollingworth, P. (Paul), Aspelund, T. (Thor), Hernández, I. (Isabel), Beiser, A. (Alexa), Kuller, L.H. (Lewis), Koudstaal, P.J. (Peter), Dickson, D. (Dennis), Tzourio, C. (Christophe), Abraham, R. (Richard), Antúnez, C. (C.), Du, Y. (Yangchun), Rotter, J.I. (Jerome I.), Aulchenko, Y.S. (Yurii), Harris, T.B. (Tamara), Petersen, R.C. (Ronald C.), Berr, C. (Claudine), Owen, M.J. (Michael), López-Arrieta, J. (J.), Vardarajan, B.N. (Badri), Becker, J.T. (James), Rivadeneira Ramirez, F. (Fernando), Nalls, M.A. (Michael), Graff-Radford, N.R. (Neill), Campion, D. (Dominique), Auerbach, S. (Sanford), Rice, K.M. (Kenneth), Hofman, A. (Albert), Jonsson, P.V. (Palmi V.), Schmidt, H. (Helena), Lathrop, M. (Mark), Mosley, T.H. (Thomas H.), Au, R. (Rhoda), Psaty, B.M. (Bruce), Uitterlinden, A.G. (André), Farrer, L.A. (Lindsay), Lumley, T. (Thomas), Ruiz, A. (A.), Williams, J. (Julie), Amouyel, P. (Philippe), Younkin, S., Wolf, P.A. (Philip A.), Launer, L.J. (Lenore), Lopez, O.L. (Oscar), Duijn, C.M. (Cornelia) van, and Breteler, M.M.B. (Monique)
Abstract: Context: Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives: To identify and strengthen additional loci associated with AD and confirm these in an independent sample and to examine the contribution of recently identified genes to AD risk prediction in a 3-stage analysis of new and previously published GWAS on more than 35 000 persons (8371 AD cases). Design, Setting, and Participants: In stage 1, we identified strong genetic associations (P<10-3) in a sample of 3006 AD cases and 14 642 controls by combining new data from the population-based Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (1367 AD cases [973 incident]) with previously reported results from the Translational Genomics Research Institute and the Mayo AD GWAS. We identified 2708 single-nucleotide polymorphisms (SNPs) with P<10-3. In stage 2, we pooled results for these SNPs with the European AD Initiative (2032 cases and 5328 controls) to identify 38 SNPs (10 loci) with P<10-5. In stage 3, we combined data for these 10 loci with data from the Genetic and Environmental Risk in AD consortium (3333 cases and 6995 controls) to identify 4 SNPs with P<1.7 × 10-8. These 4 SNPs were replicated in an independent Spanish sample (1140 AD cases and 1209 controls). Genome-wide association analyses were completed in 2007-2008 and the meta-analyses and replication in 2009. Main Outcome Measure: Presence of Alzheimer disease. Results: Two loci were identified to have genome-wide significance for the first time: rs744373 near BIN1 (odds ratio [OR],1.13; 95% confidence interval [CI],1.06-1.21 per copy of the minor allele; P=1.59×10-11) and rs597668 near EXOC3L2/BLOC1S3/ MARK4 (OR, 1.18; 95% CI, 1.07-1.29; P=6.45×10-9). Associations of these 2 loci plus the previously identified loci CLU and PICALM with AD were confirmed in the Spanish sample (P<.05). However, although CLU and PICALM were confirmed to
Published: 2010
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26. Genome-wide association studies of mri-defined brain infarcts: Meta-analysis from the charge consortium

Author: Debette, S. (Stéphanie), Bis, J.C. (Joshua), Fornage, M. (Myriam), Schmid, H.A. (Herbert), Ikram, M.A. (Arfan), Sigurdsson, S. (Stefan), Heiss, G. (Gerardo), Struchalin, M.V. (Maksim), Smith, A.V. (Albert Vernon), Lugt, A. (Aad) van der, DeCarli, C. (Charles), Lumley, T. (Thomas), Knopman, D.S. (David), Enzinger, C. (Christian), Eiriksdottir, G. (Gudny), Koudstaal, P.J. (Peter), DeStefano, A.L. (Anita), Psaty, B.M. (Bruce), Dufouil, C. (Carole), Catellier, D.J. (Diane), Fazekas, F. (Franz), Aspelund, T. (Thor), Aulchenko, Y.S. (Yurii), Beiser, A. (Alexa), Rotter, J.I. (Jerome), Tzourio, C. (Christophe), Shibata, D.K. (Dean), Tscherner, M. (Maria), Harris, T.B. (Tamara), Rivadeneira Ramirez, F. (Fernando), Atwood, L.D. (Larry), Rice, K. (Kenneth), Gottesman, R.F. (Rebecca), Buchem, M.A. (Mark) van, Uitterlinden, A.G. (André), Kelly-Hayes, M. (Margaret), Cushman, M. (Mary Ann), Zhu, Y. (Yicheng), Boerwinkle, E.A. (Eric), Gudnason, V. (Vilmundur), Hofman, A. (Albert), Romero, J.R. (Jose Rafael), Breteler, M.M.B. (Monique), Schmidt, R. (Reinhold), Launer, L.J. (Lenore), Longstreth Jr, W.T., Debette, S. (Stéphanie), Bis, J.C. (Joshua), Fornage, M. (Myriam), Schmid, H.A. (Herbert), Ikram, M.A. (Arfan), Sigurdsson, S. (Stefan), Heiss, G. (Gerardo), Struchalin, M.V. (Maksim), Smith, A.V. (Albert Vernon), Lugt, A. (Aad) van der, DeCarli, C. (Charles), Lumley, T. (Thomas), Knopman, D.S. (David), Enzinger, C. (Christian), Eiriksdottir, G. (Gudny), Koudstaal, P.J. (Peter), DeStefano, A.L. (Anita), Psaty, B.M. (Bruce), Dufouil, C. (Carole), Catellier, D.J. (Diane), Fazekas, F. (Franz), Aspelund, T. (Thor), Aulchenko, Y.S. (Yurii), Beiser, A. (Alexa), Rotter, J.I. (Jerome), Tzourio, C. (Christophe), Shibata, D.K. (Dean), Tscherner, M. (Maria), Harris, T.B. (Tamara), Rivadeneira Ramirez, F. (Fernando), Atwood, L.D. (Larry), Rice, K. (Kenneth), Gottesman, R.F. (Rebecca), Buchem, M.A. (Mark) van, Uitterlinden, A.G. (André), Kelly-Hayes, M. (Margaret), Cushman, M. (Mary Ann), Zhu, Y. (Yicheng), Boerwinkle, E.A. (Eric), Gudnason, V. (Vilmundur), Hofman, A. (Albert), Romero, J.R. (Jose Rafael), Breteler, M.M.B. (Monique), Schmidt, R. (Reinhold), Launer, L.J. (Lenore), and Longstreth Jr, W.T.
Abstract: Background and Purpose-Previous studies examining genetic associations with MRI-defined brain infarct have yielded inconsistent findings. We investigated genetic variation underlying covert MRI infarct in persons without histories of transient ischemic attack or stroke. We performed meta-analysis of genome-wide association studies of white participants in 6 studies comprising the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Methods-Using 2.2 million genotyped and imputed single nucleotide polymorphisms, each study performed crosssectional genome-wide association analysis of MRI infarct using age- and sex-adjusted logistic regression models. Study-specific findings were combined in an inverse-variance-weighted meta-analysis, including 9401 participants with mean age 69.7 (19.4% of whom had 1 MRI infarct). Results-The most significant association was found with rs2208454 (minor allele frequency, 20%), located in intron 3 of MACRO domain containing 2 gene and in the downstream region of fibronectin leucine-rich transmembrane protein 3 gene. Each copy of the minor allele was associated with lower risk of MRI infarcts (odds ratio, 0.76; 95% confidence interval, 0.68-0.84; P4.64107). Highly suggestive associations (P1.0105) were also found for 22 other single nucleotide polymorphisms in linkage disequilibrium (r20.64) with rs2208454. The association with rs2208454 did not replicate in independent samples of 1822 white and 644 black participants, although 4 single nucleotide polymorphisms within 200 kb from rs2208454 were associated with MRI infarcts in the black population sample. Conclusions-This first community-based, genome-wide association study on covert MRI infarcts uncovered novel associations. Although replication of the association with top single nucleotide polymorphisms failed, possibly because of insufficient power, results in the black population sample are encouraging, and further efforts at replication are needed.
Published: 2010
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26 results on '"Tzourio, C. (Christophe)"'

1. National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio:a pooled analysis of 458 population-based studies in Asian and Western countries

2. Cerebral small vessel disease genomics and its implications across the lifespan

3. Repositioning of the global epicentre of non-optimal cholesterol

4. Correction: Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation (Molecular Psychiatry, (2018), 10.1038/s41380-018-0112-7)

5. Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease

6. Erratum to: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

7. Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease

8. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

9. Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

10. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

11. Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium

12. Novel genetic loci associated with hippocampal volume

13. Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults:results from a meta-analysis and exploratory meta-regression analysis

14. Worldwide trends in blood pressure from 1975 to 2015:a pooled analysis of 1479 population-based measurement studies with 19.1 million participants

15. Worldwide trends in diabetes since 1980: A pooled analysis of 751 population-based studies with 4.4 million participants

16. A century of trends in adult human height

17. Trends in adult body-mass index in 200 countries from 1975 to 2014: A pooled analysis of 1698 population-based measurement studies with 19.2 million participants

18. Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease

19. White Matter Lesion Progression: Genome-Wide Search for Genetic Influences

20. Genome-wide studies of verbal declarative memory in nondemented older people: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

21. Association of Alzheimer's disease GWAS loci with MRI markers of brain aging

22. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

23. The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism

24. Genome-wide association studies of cerebral white matter lesion burden

25. Genome-wide analysis of genetic loci associated with Alzheimer disease

26. Genome-wide association studies of mri-defined brain infarcts: Meta-analysis from the charge consortium

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26 results on '"Tzourio, C. (Christophe)"'

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