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180 results on '"Tyburski, James G."'

6. When More Is Still Not Enough: A Case of Ceftazidime-Avibactam Resistance in a Burn Patient.

Author

Herbin, Shelbye R, Barber, Katie E, Isaacson, Andrew R, Dolman, Heather S, McGee, Jessica D, Baylor, Alfred E, Tyburski, James G, White, Michael T, and Faris, Janie

Subjects
BURNS & scalds complications, ANTIBIOTICS, CEFTAZIDIME, BURN patients, WOUND infections, GENETIC testing, PSEUDOMONAS diseases, MULTIDRUG resistance
Abstract

Burn patients have numerous risk factors for multidrug-resistant organisms (MDROs) and altered pharmacokinetics, which both independently increase the risk of treatment failure. Data on appropriate antimicrobial dosing are limited in this population and therapeutic drug monitoring (TDM) for beta-lactams is impractical at most facilities. Technology is available that can detect genetic markers of resistance, but they are not all encompassing, and often require specialized facilities that can detect less common genetic markers. Newer antimicrobials can help combat MDROs, but additional resistance patterns may evolve during treatment. Considering drug shortages and antimicrobial formularies, clinicians must remain vigilant when treating infections. This case report describes the development of resistance to ceftazidime-avibactam in a burn patient. The patient was a 54-year-old burn victim with a 58% total body surface area (TBSA) thermal burn who underwent multiple courses of antibiotics for various Pseudomonal infections. The initial Pseudomonal wound infection was sensitive to cefepime, aminoglycosides, and meropenem. A subsequent resistant pseudomonal pneumonia was treated with ceftazidime-avibactam 2.5 g every 6 hours due to the elevated MIC to cefepime (16 mcg/mL) and meropenem (>8 mcg/mL). Although the patient improved over 7 days, the patient again spiked fevers and had increased white blood counts (WBC). Repeat blood cultures demonstrated a multidrug-resistant (MDR) Pseudomonas with a minimum inhibitory concentration (MIC) to ceftazidime-avibactam of 16 mcg/mL, which is above the Clinical and Laboratory Standards Institute (CLSI) breakpoint of 8 mcg/mL. At first, resistance was thought to have occurred due to inadequate dosing, but genetic work demonstrated multiple genes encoding beta-lactamases. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Lipopolysaccharide activation of pericyte's Toll-like receptor-4 regulates co-culture permeability

Author

Edelman, David A., Jiang, Yang, Tyburski, James G., Wilson, Robert F., and Steffes, Christopher P.

Subjects
Health
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.amjsurg.2006.08.086 Byline: David A. Edelman, Yang Jiang, James G. Tyburski, Robert F. Wilson, Christopher P. Steffes Keywords: Pericytes; TLR-4; Acute respiratory distress syndrome; Co-culture; Permeability; Capillary leak Abstract: Pericytes (PCs) have a synergistic relationship with endothelial cells (MVEC) in regulating capillary permeability. PCs express Toll-like receptor-4 (TLR-4). We hypothesize one mechanism of MVEC/PC co-culture permeability is regulated through lipopolysaccharide (LPS) activation of pericyte TLR-4. Author Affiliation: Department of Surgery, Wayne State University, 3900 John R, Suite 400 POB, Detroit, MI 48201, USA Article History: Received 20 July 2006; Revised 24 August 2006

Published
2007

10. Vascular endothelial growth factor modulates contractile response in microvascular lung pericytes

Author

Donoghue, Lydia, Tyburski, James G., Steffes, Christopher P., and Wilson, Robert F.

Subjects
Vascular endothelial growth factor, Permeability, Health
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.amjsurg.2005.10.034 Byline: Lydia Donoghue, James G. Tyburski, Christopher P. Steffes, Robert F. Wilson Keywords: Inflammation; Microvascular permeability; Pericyte; Sepsis; Vascular endothelial growth factor Abstract: Pericytes are capillary support cells that may play a role in regulating permeability by their contractile responses. Vascular endothelial growth factor (VEGF) may play a role in the increased permeability found in sepsis and other inflammatory conditions. The purpose of this study was to evaluate the role of VEGF in regulating pericyte contraction. Author Affiliation: Department of Surgery, Wayne State University, Harper Professional Office Bldg., 3990 John R. Suite 400, Detroit, MI 48201, USA Article History: Received 17 August 2005; Revised 28 October 2005

Published
2006

17. Sports concussion: Implications of the exam after head injury. (Primary Care Update)

Author

Wilson, Robert F., Carlin, Arthur M., and Tyburski, James G.

Subjects
Brain -- Concussion, Head injuries -- Care and treatment, Athletes -- Injuries, Sports injuries -- Care and treatment, Health, Care and treatment, Injuries
Abstract

As many as 300,000 sports-related concussions are diagnosed each year in the United States. (1) This figure underestimates the true incidence, however, because many concussive injuries are not recognized by [...]

Published
2002

19. A Cautionary Tale of Etanercept Use in Patients With Toxic Epidermal Necrolysis.

Author

Faris, Janie, Wilson, Jordan, Dolman, Heather S, Isaacson, Andrew, Baylor, Alfred E, Tyburski, James G, and White, Michael T

Subjects
TUMOR necrosis factors, LENGTH of stay in hospitals, ETANERCEPT, FLUID therapy, TOXIC epidermal necrolysis, STEVENS-Johnson Syndrome, TREATMENT effectiveness, IMMUNOSUPPRESSIVE agents, DISEASE complications
Abstract

Toxic epidermal necrolysis (TEN) is a severe cutaneous reaction that can be life-threatening. In the United States, there are no established guidelines for the treatment of TEN. Supportive care including fluids and supportive therapies are the current recommendations. Research surrounding TEN involves mostly case studies or small, uncontrolled studies. Recent literature describes the use of tumor necrosis factor blockers in the treatment of TEN with positive results. These case reports describe decreased time to reepithelization, hospital length of stay, and minimal side effects. Conversely, we present three fatalities after the administration of etanercept. [ABSTRACT FROM AUTHOR]

Published
2021
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25. Lipopolysaccharide induces relaxation in lung pericytes by an iNOS-independent mechanism

Author

SPEYER, CECILIA L., STEFFES, CHRISTOPHER P., TYBURSKI, JAMES G., and RAM, JEFFREY L.

Subjects
Bacterial infections -- Physiological aspects, Endotoxins -- Physiological aspects, Nitric oxide -- Physiological aspects, Biological sciences
Abstract

Lipopolysaccharide induces relaxation in lung pericytes by an iNOS-independent mechanism. Am J Physiol Lung Cell Mol Physiol 278: L880-L887, 2000.--Lipopolysaccharide (LPS)-regulated contractility in pericytes may play an important role in mediating pulmonary microvascular fluid hemodynamics during inflammation and sepsis. LPS has been shown to regulate inducible nitric oxide (NO) synthase (iNOS) in various cell types, leading to NO generation, which is associated with vasodilatation. The purpose of this study was to test the hypothesis that LPS can regulate relaxation in lung pericytes and to determine whether this relaxation is mediated through the iNOS pathway. As predicted, LPS stimulated NO synthesis and reduced basal tension by 49% (P [is less than] 0.001). However, the NO synthase inhibitors N[Omega]-nitro-L-arginine methyl ester, aminoguanidine, and N[Omega]-monomethyl-L-arginine did not block the relaxation produced by LPS. In fact, aminoguanidine and N[Omega]-monomethyl-L-arginine potentiated the LPS response. The possibility that NO might mediate either contraction or relaxation of the pericyte was further investigated through the use of NO donor compounds; however, neither sodium nitroprusside nor S-nitroso-N-acetylpenicillamine had any significant effect on pericyte contraction. The inhibitory effect of aminoguanidine on LPS-stimulated NO production was confirmed. This ability of LPS to inhibit contractility independent of iNOS was also demonstrated in lung pericytes derived from iNOS-deficient mice. This suggests the presence of an iNOS-independent but as yet undetermined pathway by which lung pericyte contractility is regulated. nitric oxide; sepsis; inducible nitric oxide synthase

Published
2000

29. Impact of evaluating antibiotic concentrations in abdominal abscesses percutaneously drained

Author

Zimmerman, Lisa Hall, primary, Tyburski, James G., additional, Glowniak, Jerry, additional, Singla, Rohit, additional, Lavery, Todd, additional, Nailor, Michael, additional, Stassinopoulus, Jerry, additional, Hong, Kaleford, additional, Barshikar, Surendra, additional, Dolman, Heather S., additional, Baylor, Alfred E., additional, and Wilson, Robert F., additional

Published
2011
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30. Civilian Gunshot Wounds of the Hip and Pelvis

Author

Bartkiw, Mykola J, primary, Sethi, Anil, additional, Coniglione, Franco, additional, Holland, Danny, additional, Hoard, Daniel, additional, Colen, Robert, additional, Tyburski, James G, additional, and Vaidya, Rahul, additional

Published
2010
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42. Prognostic Determinants in Duodenal Injuries

Author

Blocksom, Jason M., primary, Tyburski, James G., additional, Sohn, Richard L., additional, Williams, Mallory, additional, Harvey, E., additional, Steffes, Christopher P., additional, Carlin, Arthur M., additional, and Wilson, Robert F., additional

Published
2004
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