Lipopolysaccharide activation of pericyte's Toll-like receptor-4 regulates co-culture permeability

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.amjsurg.2006.08.086 Byline: David A. Edelman, Yang Jiang, James G. Tyburski, Robert F. Wilson, Christopher P. Steffes Keywords: Pericytes; TLR-4; Acute respiratory distress syndrome; Co-culture; Permeability; Capillary leak Abstract: Pericytes (PCs) have a synergistic relationship with endothelial cells (MVEC) in regulating capillary permeability. PCs express Toll-like receptor-4 (TLR-4). We hypothesize one mechanism of MVEC/PC co-culture permeability is regulated through lipopolysaccharide (LPS) activation of pericyte TLR-4. Author Affiliation: Department of Surgery, Wayne State University, 3900 John R, Suite 400 POB, Detroit, MI 48201, USA Article History: Received 20 July 2006; Revised 24 August 2006