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7. Proposed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph)

Author

Morton, Lindsay M., Turner, Jennifer J., Cerhan, James R., Linet, Martha S., Treseler, Patrick A., Clarke, Christina A., Jack, Andrew, Cozen, Wendy, Maynadié, Marc, Spinelli, John J., Costantini, Adele Seniori, Rüdiger, Thomas, Scarpa, Aldo, Zheng, Tongzhang, and Weisenburger, Dennis D.

Published
2007
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8. Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer

Author

Henshall, Susan M, Afar, Daniel E H, Rasiah, Krishan K, Horvath, Lisa G, Gish, Kurt, Caras, Ingrid, Ramakrishnan, Vanitha, Wong, Melanie, Jeffry, Ursula, Kench, James G, Quinn, David I, Turner, Jennifer J, Delprado, Warick, Lee, C-Soon, Golovsky, David, Brenner, Phillip C, O'Neill, Gordon F, Kooner, Raji, Stricker, Phillip D, Grygiel, John J, Mack, David H, and Sutherland, Robert L

Published
2003
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14. Prognostic significance of gleason pattern in patients with gleason score 7 prostate carcinoma

Author

Rasiah, Kris K., Stricker, Phillip D., Haynes, Anne-Maree, Delprado, Warick, Turner, Jennifer J., Golovsky, David, Brenner, Phillip C., Kooner, Raji, O'Neill, Gordon F., Grygiel, John J., Sutherland, Robert L., and Henshall, Susan M.

Subjects
Prostate diseases -- Care and treatment, Prostate diseases -- Research, Prostate cancer -- Care and treatment, Prostate cancer -- Research, Health
Published
2003

15. Prognostic significance of preoperative factors in localized prostate carcinoma treated with radical prostatectomy: importance of percentage of biopsies that contain tumor and the presence of biopsy perineural invasion

Author

Quinn, David I., Henshall, Susan M., Brenner, Phillip C., Kooner, Raji, Golovsky, David, O'Neill, Gordon F., Turner, Jennifer J., Delprado, Warick, Grygiel, John J., Sutherland, Robert L., and Stricker, Phillip D.

Subjects
Prostate cancer -- Patient outcomes, Prostate cancer -- Prognosis, Prostate cancer -- Care and treatment, Prostatectomy -- Patient outcomes, Cancer invasiveness -- Physiological aspects, Cancer patients -- Prognosis, Health
Published
2003

20. Rationale and design of the International Lymphoma Epidemiology Consortium (InterLymph) non-Hodgkin lymphoma subtypes project

Author

Morton, Lindsay M., Sampson, Joshua N., Cerhan, James R., Turner, Jennifer J., Vajdic, Claire M., Wang, Sophia S., Smedby, Karin E., De Sanjosé, Silvia, Monnereau, Alain, Benavente, Yolanda, Bracci, Paige M., Chiu, Brian C.H., Skibola, Christine F., Zhang, Yawei, Mbulaiteye, Sam M., Spriggs, Michael, Robinson, Dennis, Norman, Aaron D., Kane, Eleanor V., Spinelli, John J., Kelly, Jennifer L., La Vecchia, Carlo, Maso, Luigino Dal, Maynadié, Marc, Kadin, Marshall E., Cocco, Pierluigi, Costantini, Adele Seniori, Clarke, Christina A., Roman, Eve, Miligi, Lucia, Colt, Joanne S., Berndt, Sonja I., Mannetje, Andrea, de Roos, Anneclaire J., Kricker, Anne, Nieters, Alexandra, Franceschi, Silvia, Melbye, Mads, Boffetta, Paolo, Clavel, Jacqueline, Linet, Martha S., Weisenburger, Dennis D., Slager, Susan L., Morton, Lindsay M., Sampson, Joshua N., Cerhan, James R., Turner, Jennifer J., Vajdic, Claire M., Wang, Sophia S., Smedby, Karin E., De Sanjosé, Silvia, Monnereau, Alain, Benavente, Yolanda, Bracci, Paige M., Chiu, Brian C.H., Skibola, Christine F., Zhang, Yawei, Mbulaiteye, Sam M., Spriggs, Michael, Robinson, Dennis, Norman, Aaron D., Kane, Eleanor V., Spinelli, John J., Kelly, Jennifer L., La Vecchia, Carlo, Maso, Luigino Dal, Maynadié, Marc, Kadin, Marshall E., Cocco, Pierluigi, Costantini, Adele Seniori, Clarke, Christina A., Roman, Eve, Miligi, Lucia, Colt, Joanne S., Berndt, Sonja I., Mannetje, Andrea, de Roos, Anneclaire J., Kricker, Anne, Nieters, Alexandra, Franceschi, Silvia, Melbye, Mads, Boffetta, Paolo, Clavel, Jacqueline, Linet, Martha S., Weisenburger, Dennis D., and Slager, Susan L.

Abstract

Background: Non-Hodgkin lymphoma (NHL), the most common hematologic malignancy, consists of numerous subtypes. The etiology of NHL is incompletely understood, and increasing evidence suggests that risk factors may vary by NHL subtype. However, small numbers of cases have made investigation of subtype-specific risks challenging. The International Lymphoma Epidemiology Consortium therefore undertook the NHL Subtypes Project, an international collaborative effort to investigate the etiologies of NHL subtypes. This article describes in detail the project rationale and design. Methods: We pooled individual-level data from 20 case-control studies (17 471 NHL cases, 23 096 controls) from North America, Europe, and Australia. Centralized data harmonization and analysis ensured standardized definitions and approaches, with rigorous quality control. Results: The pooled study population included 11 specified NHL subtypes with more than 100 cases: diffuse large B-cell lymphoma (N = 4667), follicular lymphoma (N = 3530), chronic lymphocytic leukemia/small lymphocytic lymphoma (N = 2440), marginal zone lymphoma (N = 1052), peripheral T-cell lymphoma (N = 584), mantle cell lymphoma (N = 557), lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (N = 374), mycosis fungoides/Sézary syndrome (N = 324), Burkitt/Burkitt-like lymphoma/leukemia (N = 295), hairy cell leukemia (N = 154), and acute lymphoblastic leukemia/lymphoma (N = 152). Associations with medical history, family history, lifestyle factors, and occupation for each of these 11 subtypes are presented in separate articles in this issue, with a final article quantitatively comparing risk factor patterns among subtypes. Conclusions: The International Lymphoma Epidemiology Consortium NHL Subtypes Project provides the largest and most comprehensive investigation of potential risk factors for a broad range of common and rare NHL subtypes to date. The analyses contribute to our understanding of the multifactorial nature of

Published
2014

21. Etiologic heterogeneity among non-hodgkin lymphoma subtypes:The interLymph non-hodgkin lymphoma subtypes project

Author

Morton, Lindsay M., Slager, Susan L., Cerhan, James R., Wang, Sophia S., Vajdic, Claire M., Skibola, Christine F., Bracci, Paige M., de Sanjosé, Silvia, Smedby, Karin E., Chiu, Brian C.H., Zhang, Yawei, Mbulaiteye, Sam M., Monnereau, Alain, Turner, Jennifer J., Clavel, Jacqueline, Adami, Hans Olov, Chang, Ellen T., Glimelius, Bengt, Hjalgrim, Henrik, Melbye, Mads, Crosignani, Paolo, di Lollo, Simonetta, Miligi, Lucia, Nanni, Oriana, Ramazzotti, Valerio, Rodella, Stefania, Costantini, Adele Seniori, Stagnaro, Emanuele, Tumino, Rosario, Vindigni, Carla, Vineis, Paolo, Becker, Nikolaus, Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Cocco, Pierluigi, Foretova, Lenka, Maynadié, Marc, Nieters, Alexandra, Staines, Anthony, Colt, Joanne S., Cozen, Wendy, Davis, Scott, de Roos, Anneclaire J., Hartge, Patricia, Rothman, Nathaniel, Severson, Richard K., Holly, Elizabeth A., Call, Timothy G., Feldman, Andrew L., Habermann, Thomas M., Liebow, Mark, Blair, Aaron, Cantor, Kenneth P., Kane, Eleanor V., Lightfoot, Tracy, Roman, Eve, Smith, Alex, Brooks-Wilson, Angela, Connors, Joseph M., Gascoyne, Randy D., Spinelli, John J., Armstrong, Bruce K., Kricker, Anne, Holford, Theodore R., Lan, Qing, Zheng, Tongzhang, Orsi, Laurent, Dal Maso, Luigino, Franceschi, Silvia, La Vecchia, Carlo, Negri, Eva, Serraino, Diego, Bernstein, Leslie, Levine, Alexandra, Friedberg, Jonathan W., Kelly, Jennifer L., Berndt, Sonja I., Birmann, Brenda M., Clarke, Christina A., Flowers, Christopher R., Foran, James M., Kadin, Marshall E., Paltiel, Ora, Weisenburger, Dennis D., Linet, Martha S., Sampson, Joshua N., Morton, Lindsay M., Slager, Susan L., Cerhan, James R., Wang, Sophia S., Vajdic, Claire M., Skibola, Christine F., Bracci, Paige M., de Sanjosé, Silvia, Smedby, Karin E., Chiu, Brian C.H., Zhang, Yawei, Mbulaiteye, Sam M., Monnereau, Alain, Turner, Jennifer J., Clavel, Jacqueline, Adami, Hans Olov, Chang, Ellen T., Glimelius, Bengt, Hjalgrim, Henrik, Melbye, Mads, Crosignani, Paolo, di Lollo, Simonetta, Miligi, Lucia, Nanni, Oriana, Ramazzotti, Valerio, Rodella, Stefania, Costantini, Adele Seniori, Stagnaro, Emanuele, Tumino, Rosario, Vindigni, Carla, Vineis, Paolo, Becker, Nikolaus, Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Cocco, Pierluigi, Foretova, Lenka, Maynadié, Marc, Nieters, Alexandra, Staines, Anthony, Colt, Joanne S., Cozen, Wendy, Davis, Scott, de Roos, Anneclaire J., Hartge, Patricia, Rothman, Nathaniel, Severson, Richard K., Holly, Elizabeth A., Call, Timothy G., Feldman, Andrew L., Habermann, Thomas M., Liebow, Mark, Blair, Aaron, Cantor, Kenneth P., Kane, Eleanor V., Lightfoot, Tracy, Roman, Eve, Smith, Alex, Brooks-Wilson, Angela, Connors, Joseph M., Gascoyne, Randy D., Spinelli, John J., Armstrong, Bruce K., Kricker, Anne, Holford, Theodore R., Lan, Qing, Zheng, Tongzhang, Orsi, Laurent, Dal Maso, Luigino, Franceschi, Silvia, La Vecchia, Carlo, Negri, Eva, Serraino, Diego, Bernstein, Leslie, Levine, Alexandra, Friedberg, Jonathan W., Kelly, Jennifer L., Berndt, Sonja I., Birmann, Brenda M., Clarke, Christina A., Flowers, Christopher R., Foran, James M., Kadin, Marshall E., Paltiel, Ora, Weisenburger, Dennis D., Linet, Martha S., and Sampson, Joshua N.

Abstract

Background: Non-Hodgkin lymphoma (NHL) comprises biologically and clinically heterogeneous subtypes. Previously, study size has limited the ability to compare and contrast the risk factor profiles among these heterogeneous subtypes. Methods: We pooled individual-level data from 17 471 NHL cases and 23 096 controls in 20 case-control studies from the International Lymphoma Epidemiology Consortium (InterLymph). We estimated the associations, measured as odds ratios, between each of 11 NHL subtypes and self-reported medical history, family history of hematologic malignancy, lifestyle factors, and occupation. We then assessed the heterogeneity of associations by evaluating the variability (Q value) of the estimated odds ratios for a given exposure among subtypes. Finally, we organized the subtypes into a hierarchical tree to identify groups that had similar risk factor profiles. Statistical significance of tree partitions was estimated by permutation-based P values (PNODE). Results: Risks differed statistically significantly among NHL subtypes for medical history factors (autoimmune diseases, hepatitis C virus seropositivity, eczema, and blood transfusion), family history of leukemia and multiple myeloma, alcohol consumption, cigarette smoking, and certain occupations, whereas generally homogeneous risks among subtypes were observed for family history of NHL, recreational sun exposure, hay fever, allergy, and socioeconomic status. Overall, the greatest difference in risk factors occurred between T-cell and B-cell lymphomas (PNODE < 1.0 × 10-4), with increased risks generally restricted to T-cell lymphomas for eczema, T-cell-activating autoimmune diseases, family history of multiple myeloma, and occupation as a painter. We further observed substantial heterogeneity among B-cell lymphomas (PNODE < 1.0 × 10-4). Increased risks for B-cell-activating autoimmune disease and hepatitis C virus seropositivity and de

Published
2014

23. Synthesis and properties of chiral molecular clefts related to Troeger's base

Author

Harding, Margaret, Turner, Jennifer J, Harding, Margaret, and Turner, Jennifer J

Abstract

The chiral cavities present in 2,3:6,7-dibenzo-9-oxabicyclonona-2,6-diene, dibenzobicyclo[b,f][3.3.1]nona-5a, 6a-diene-6,12-dione, bicyclo[3.3.1]nonane and dibenzobicyclo[b,f][1,5]diazocines are reminiscent of Tröger's base, which has been widely used as

Published
2005

24. Ligand self-recognition in the stereoselective assembly of [2 + 2] metallomacrocycles from racemic chiral bisbipyridyl molecular clefts and zinc(II)

Author

Anderberg, Pia I, Turner, Jennifer J, Evans, Krystal J, Hutchins, Lauren M, Harding, Margaret, Anderberg, Pia I, Turner, Jennifer J, Evans, Krystal J, Hutchins, Lauren M, and Harding, Margaret

Abstract

The synthesis of racemic and optically pure ligand L, in which two 6,6′-disubstituted bipyridines are connected by methyleneoxy linkers to the molecular cleft dibenzobicyclo[b,f][3.3.1.]nona-5a,6a-diene-6,12-dione, is reported. In the presence of 2 equi

Published
2004

25. High Gleason grade carcinoma at a positive surgical margin predicts biochemical failure after radical prostatectomy and may guide adjuvant radiotherapy

Author

Savdie, Richard, primary, Horvath, Lisa G., additional, Benito, Ruth Pe, additional, Rasiah, Krishan K., additional, Haynes, Anne-Maree, additional, Chatfield, Mark, additional, Stricker, Phillip D., additional, Turner, Jennifer J., additional, Delprado, Warwick, additional, Henshall, Susan M., additional, Sutherland, Robert L., additional, and Kench, James G., additional

Published
2011
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27. 300 CAN THE GLEASON GRADE AT THE SITE OF A POSITIVE MARGIN PREDICT BIOCHEMICAL FAILURE POST RADICAL PROSTATECTOMY?

Author

Savdie, Richard, primary, Pe Benito, Ruth A., additional, Haynes, Anne-Maree, additional, Stricker, Phillip D., additional, Henshall, Susan M., additional, Sutherland, Robert L., additional, Turner, Jennifer J., additional, Delprado, Warick, additional, Horvath, Lisa G., additional, Rasiah, Krishan K., additional, and Kench, James G., additional

Published
2010
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30. Aberrant Neuropeptide Y and Macrophage Inhibitory Cytokine-1 Expression Are Early Events in Prostate Cancer Development and Are Associated with Poor Prognosis

Author

Rasiah, Krishan K., primary, Kench, James G., additional, Gardiner-Garden, Margaret, additional, Biankin, Andrew V., additional, Golovsky, David, additional, Brenner, Phillip C., additional, Kooner, Raji, additional, O'Neill, Gordon F., additional, Turner, Jennifer J., additional, Delprado, Warick, additional, Lee, C. Soon, additional, Brown, David A., additional, Breit, Samuel N., additional, Grygiel, John J., additional, Horvath, Lisa G., additional, Stricker, Phillip D., additional, Sutherland, Robert L., additional, and Henshall, Susan M., additional

Published
2006
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34. Birth Order, Atopy, and Risk of Non-Hodgkin Lymphoma.

Author

Grulich, Andrew E., primary, Vajdic, Claire, additional, Kaldor, John M., additional, Hughes, Anne-Maree, additional, Kricker, Anne, additional, Fritschi, Lin, additional, Turner, Jennifer J., additional, Milliken, Sam, additional, Benke, Geza, additional, and Armstrong, Bruce K., additional

Published
2004
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35. Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression

Author

Horvath, Lisa G., primary, Henshall, Susan M., additional, Kench, James G., additional, Turner, Jennifer J., additional, Golovsky, David, additional, Brenner, Phillip C., additional, O'Neill, Gordon F., additional, Kooner, Raji, additional, Stricker, Phillip D., additional, Grygiel, John J., additional, and Sutherland, Robert L., additional

Published
2004
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36. 1079: Neuropeptide Y Expression is increased in the Progression from Benign to Malignant Prostate Epithelium and Predicts Outcome after Radical Prostatectomy

Author

Rasiah, Kris K., primary, Kench, James G., additional, Gardiner-Garden, Margaret, additional, Horvath, Lisa G., additional, Biankin, Andrew V., additional, Walsh, Rebecca, additional, Turner, Jennifer J., additional, Lee, C. Soon, additional, Delprado, Warick, additional, Golovsky, David, additional, Brenner, Phillip C., additional, Kooner, Raji, additional, O'Neill, Gordon F., additional, Stricker, Phillip D., additional, Sutherland, Robert L., additional, and Henshall, Susan M., additional

Published
2004
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41. Lymphoid neoplasm incidence by WHO subtype in Australia 1982-2006.

Author

Leeuwen, Marina T., Turner, Jennifer J., Joske, David J., Falster, Michael O., Srasuebkul, Preeyaporn, Meagher, Nicola S., Grulich, Andrew E., Giles, Graham G., and Vajdic, Claire M.

Abstract

There are limited data characterizing the subtype-specific incidence of lymphoid neoplasms in the World Health Organization (WHO) Classification era. Data were obtained on all incident lymphoid neoplasms registered in Australia during 1982-2006. Subtypes were grouped using the InterLymph nested hierarchical classification, based on the 2008 WHO Classification. Temporal trends were examined using Joinpoint regression; average annual percentage change in incidence was computed. Multiple Poisson regression was used to compare incidence by sex and age. The incidence of all non-Hodgkin lymphoma (NHL) increased by 2.5%/year during 1982-1996 and was stable thereafter. During 1997-2006, several mature B- and natural killer (NK)-/T-cell NHL subtypes increased in incidence, including diffuse large B-cell (1.3%/year), follicular (2.5%/year), Burkitt (6.8%/year), marginal zone (13.2%/year), mantle cell (4.2%/year), peripheral T-cell lymphoma (4.7%/year) and plasmacytoma (7.1%/year). While chronic lymphocytic leukemia incidence was stable, small lymphocytic lymphoma incidence declined (8.1%/year). Hodgkin lymphoma (HL) incidence increased during 1997-2006 (2.2%/year), both classical (4.3%/year) and nodular lymphocyte predominant (12.1%/year) HL. Diagnostic artifact, evidenced by a sustained decline in the incidence of NHL not otherwise specified (NOS; 5.8%/year) and lymphoid neoplasms NOS (5.6%/year), limits the interpretation of temporal trends for some subtypes. A marked male predominance was observed for almost all subtypes. Incidence of mature B- and NK-/T-cell NHL subtypes increased sharply with age, except for Burkitt lymphoma/leukemia. For HL subtypes, a bimodal age distribution was only evident for nodular sclerosis HL. Variation in incidence patterns over time and by sex and age supports etiological differences between lymphoid neoplasm subtypes. [ABSTRACT FROM AUTHOR]

Published
2014
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42. Etiologic Heterogeneity Among Non-Hodgkin Lymphoma Subtypes: The InterLymph Non-Hodgkin Lymphoma Subtypes Project.

Author

Morton, Lindsay M, Slager, Susan L, Cerhan, James R, Wang, Sophia S, Vajdic, Claire M, Skibola, Christine F, Bracci, Paige M, de Sanjosé, Silvia, Smedby, Karin E, Chiu, Brian C H, Zhang, Yawei, Mbulaiteye, Sam M, Monnereau, Alain, Turner, Jennifer J, Clavel, Jacqueline, Adami, Hans-Olov, Chang, Ellen T, Glimelius, Bengt, Hjalgrim, Henrik, and Melbye, Mads

Published
2014

43. Rationale and Design of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma Subtypes Project.

Author

Morton, Lindsay M, Sampson, Joshua N, Cerhan, James R, Turner, Jennifer J, Vajdic, Claire M, Wang, Sophia S, Smedby, Karin E, de Sanjosé, Silvia, Monnereau, Alain, Benavente, Yolanda, Bracci, Paige M, Chiu, Brian C H, Skibola, Christine F, Zhang, Yawei, Mbulaiteye, Sam M, Spriggs, Michael, Robinson, Dennis, Norman, Aaron D, Kane, Eleanor V, and Spinelli, John J

Published
2014

45. Medical History, Lifestyle, Family History, and Occupational Risk Factors for Marginal Zone Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project.

Author

Bracci, Paige M., Benavente, Yolanda, Turner, Jennifer J., Paltiel, Ora, Slager, Susan L., Vajdic, Claire M., Norman, Aaron D., Cerhan, James R., Chiu, Brian C. H., Becker, Nikolaus, Cocco, Pierluigi, Dogan, Ahmet, Nieters, Alexandra, Holly, Elizabeth A., Kane, Eleanor V., Smedby, Karin E., Maynadié, Marc, Spinelli, John J., Roman, Eve, and Glimelius, Bengt

Published
2014
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47. Latitude gradients for lymphoid neoplasm subtypes in Australia support an association with ultraviolet radiation exposure.

Author

Leeuwen, Marina T., Turner, Jennifer J., Falster, Michael O., Meagher, Nicola S., Joske, David J., Grulich, Andrew E., Giles, Graham G., and Vajdic, Claire M.

Abstract

Given the uncertainty surrounding solar ultraviolet radiation (UVR) exposure and risk of lymphoid neoplasms, we performed an ecological analysis of national Australian data for incident cases diagnosed between 2002 and 2006. Subtype-specific incidence was examined by latitude band (<29°S, 29-36°S, ≥37°S), a proxy for ambient UVR exposure, using multiple Poisson regression, adjusted for sex, age-group and calendar year. Incidence increased with distance from the equator for several mature B-cell non-Hodgkin lymphomas, including diffuse large B-cell [incidence rate ratio (IRR) = 1.37; 95% confidence interval (CI): 1.16-1.61 for latitude ≥37°S relative to <29°S], lymphoplasmacytic (IRR = 1.34; 95% CI: 1.12-1.61), mucosa-associated lymphoid tissue (IRR = 1.32; 95% CI: 0.97-1.80) and mantle cell lymphoma (IRR = 1.29; 95% CI: 1.05-1.58), as well as plasmacytoma (IRR = 1.52; 95% CI: 1.09-2.11) and plasma cell myeloma (IRR = 1.15; 95% CI: 1.03-1.27). A similar pattern was observed for several mature cutaneous T-cell neoplasms, including primary cutaneous anaplastic large cell lymphoma (IRR = 4.26; 95% CI: 1.85-9.84), mycosis fungoides/Sézary syndrome (IRR = 1.72; 95% CI: 1.20-2.46), and peripheral T-cell lymphoma not otherwise specified (NOS) (IRR = 1.53; 95% CI: 1.17-2.00). Incidence of mixed cellularity/lymphocyte-depleted (IRR = 1.60; 95% CI: 1.16-2.20) and nodular sclerosis Hodgkin lymphoma (IRR = 1.57; 95% CI: 1.33-1.85) also increased with distance from the equator. Many of these subtypes have a known association with infection or immune dysregulation. Our findings support a possible protective effect of UVR exposure on the risk of several lymphoid neoplasms, possibly through vitamin D-related immune modulation critical in lymphomagenesis. [ABSTRACT FROM AUTHOR]

Published
2013
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50. Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer?.

Author

Henshall, Susan M, Afar, Daniel E H, Rasiah, Krishan K, Horvath, Lisa G, Gish, Kurt, Caras, Ingrid, Ramakrishnan, Vanitha, Wong, Melanie, Jeffry, Ursula, Kench, James G, Quinn, David I, Turner, Jennifer J, Delprado, Warick, Lee, C-Soon, Golovsky, David, Brenner, Phillip C, O'Neill, Gordon F, Kooner, Raji, Stricker, Phillip D, and Grygiel, John J

Subjects
OLIGONUCLEOTIDES, PROSTATE cancer, GENOMES, CANCER, IMMUNOFLUORESCENCE, IMMUNOHISTOCHEMISTRY
Abstract

We have utilized oligonucleotide microarrays to identify novel genes of potential clinical and biological importance in prostate cancer. RNA from 74 prostate cancers and 164 normal body samples representing 40 different tissues were analysed using a customized Affymetrix GeneChip® oligonucleotide microarray representative of over 90% of the expressed human genome. The gene for the zinc transporter ZnT4 was one of several genes that displayed significantly higher expression in prostate cancer compared to normal tissues from other organs. A polyclonal antipeptide antibody was used to demonstrate ZnT4 expression in the epithelium of all 165 elements of benign and 326 elements of localized prostate cancers examined and in nine of 10 advanced prostate cancer specimens by immunohistochemistry. Interestingly, decreased intensity of ZnT4 immunoreactivity occurred in the progression from benign to invasive localized prostate cancer and to metastatic disease. Immunofluorescence analysis and surface biotinylation studies of cells expressing ZnT4 localised the protein to intracellular vesicles and to the plasma membrane. These findings are consistent with a role for ZnT4 in vesicular transport of zinc to the cell membrane and potentially in efflux of zinc in the prostate.Oncogene (2003) 22, 6005-6012. doi:10.1038/sj.onc.1206797 [ABSTRACT FROM AUTHOR]

Published
2003
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