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Etiologic heterogeneity among non-hodgkin lymphoma subtypes:The interLymph non-hodgkin lymphoma subtypes project
- Source :
- Morton , L M , Slager , S L , Cerhan , J R , Wang , S S , Vajdic , C M , Skibola , C F , Bracci , P M , de Sanjosé , S , Smedby , K E , Chiu , B C H , Zhang , Y , Mbulaiteye , S M , Monnereau , A , Turner , J J , Clavel , J , Adami , H O , Chang , E T , Glimelius , B , Hjalgrim , H , Melbye , M , Crosignani , P , di Lollo , S , Miligi , L , Nanni , O , Ramazzotti , V , Rodella , S , Costantini , A S , Stagnaro , E , Tumino , R , Vindigni , C , Vineis , P , Becker , N , Benavente , Y , Boffetta , P , Brennan , P , Cocco , P , Foretova , L , Maynadié , M , Nieters , A , Staines , A , Colt , J S , Cozen , W , Davis , S , de Roos , A J , Hartge , P , Rothman , N , Severson , R K , Holly , E A , Call , T G , Feldman , A L , Habermann , T M , Liebow , M , Blair , A , Cantor , K P , Kane , E V , Lightfoot , T , Roman , E , Smith , A , Brooks-Wilson , A , Connors , J M , Gascoyne , R D , Spinelli , J J , Armstrong , B K , Kricker , A , Holford , T R , Lan , Q , Zheng , T , Orsi , L , Dal Maso , L , Franceschi , S , La Vecchia , C , Negri , E , Serraino , D , Bernstein , L , Levine , A , Friedberg , J W , Kelly , J L , Berndt , S I , Birmann , B M , Clarke , C A , Flowers , C R , Foran , J M , Kadin , M E , Paltiel , O , Weisenburger , D D , Linet , M S & Sampson , J N 2014 , ' Etiologic heterogeneity among non-hodgkin lymphoma subtypes : The interLymph non-hodgkin lymphoma subtypes project ' , Journal of the National Cancer Institute - Monographs , no. 48 , pp. 130-144 .
- Publication Year :
- 2014
-
Abstract
- Background: Non-Hodgkin lymphoma (NHL) comprises biologically and clinically heterogeneous subtypes. Previously, study size has limited the ability to compare and contrast the risk factor profiles among these heterogeneous subtypes. Methods: We pooled individual-level data from 17 471 NHL cases and 23 096 controls in 20 case-control studies from the International Lymphoma Epidemiology Consortium (InterLymph). We estimated the associations, measured as odds ratios, between each of 11 NHL subtypes and self-reported medical history, family history of hematologic malignancy, lifestyle factors, and occupation. We then assessed the heterogeneity of associations by evaluating the variability (Q value) of the estimated odds ratios for a given exposure among subtypes. Finally, we organized the subtypes into a hierarchical tree to identify groups that had similar risk factor profiles. Statistical significance of tree partitions was estimated by permutation-based P values (PNODE). Results: Risks differed statistically significantly among NHL subtypes for medical history factors (autoimmune diseases, hepatitis C virus seropositivity, eczema, and blood transfusion), family history of leukemia and multiple myeloma, alcohol consumption, cigarette smoking, and certain occupations, whereas generally homogeneous risks among subtypes were observed for family history of NHL, recreational sun exposure, hay fever, allergy, and socioeconomic status. Overall, the greatest difference in risk factors occurred between T-cell and B-cell lymphomas (PNODE < 1.0 × 10-4), with increased risks generally restricted to T-cell lymphomas for eczema, T-cell-activating autoimmune diseases, family history of multiple myeloma, and occupation as a painter. We further observed substantial heterogeneity among B-cell lymphomas (PNODE < 1.0 × 10-4). Increased risks for B-cell-activating autoimmune disease and hepatitis C virus seropositivity and de
Details
- Database :
- OAIster
- Journal :
- Morton , L M , Slager , S L , Cerhan , J R , Wang , S S , Vajdic , C M , Skibola , C F , Bracci , P M , de Sanjosé , S , Smedby , K E , Chiu , B C H , Zhang , Y , Mbulaiteye , S M , Monnereau , A , Turner , J J , Clavel , J , Adami , H O , Chang , E T , Glimelius , B , Hjalgrim , H , Melbye , M , Crosignani , P , di Lollo , S , Miligi , L , Nanni , O , Ramazzotti , V , Rodella , S , Costantini , A S , Stagnaro , E , Tumino , R , Vindigni , C , Vineis , P , Becker , N , Benavente , Y , Boffetta , P , Brennan , P , Cocco , P , Foretova , L , Maynadié , M , Nieters , A , Staines , A , Colt , J S , Cozen , W , Davis , S , de Roos , A J , Hartge , P , Rothman , N , Severson , R K , Holly , E A , Call , T G , Feldman , A L , Habermann , T M , Liebow , M , Blair , A , Cantor , K P , Kane , E V , Lightfoot , T , Roman , E , Smith , A , Brooks-Wilson , A , Connors , J M , Gascoyne , R D , Spinelli , J J , Armstrong , B K , Kricker , A , Holford , T R , Lan , Q , Zheng , T , Orsi , L , Dal Maso , L , Franceschi , S , La Vecchia , C , Negri , E , Serraino , D , Bernstein , L , Levine , A , Friedberg , J W , Kelly , J L , Berndt , S I , Birmann , B M , Clarke , C A , Flowers , C R , Foran , J M , Kadin , M E , Paltiel , O , Weisenburger , D D , Linet , M S & Sampson , J N 2014 , ' Etiologic heterogeneity among non-hodgkin lymphoma subtypes : The interLymph non-hodgkin lymphoma subtypes project ' , Journal of the National Cancer Institute - Monographs , no. 48 , pp. 130-144 .
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1322757323
- Document Type :
- Electronic Resource