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2. α-Glucosidase inhibitory fatty acids from Morchella fluvialis mushroom

Author

Turk Ayman, Lee Solip, Lee Hak Hyun, Yeon Sang Won, Ryu Se Hwan, Seo Geum Hee, Chang Hyun You, Hwang Bang Yeon, and Lee Mi Kyeong

Subjects
α-glucosidase, linoleic acid, morchella fluvialis, morel, Plant culture, SB1-1110
Abstract

Morchella fluvialis, a morel mushroom, is one of the most famous edible mushrooms all over the world. Interest in this mushroom is steadily increasing due to its organoleptic properties and nutritional value. The methanolic extract of M. fluvialis showed α-glucosidase inhibitory and antioxidant activities in an assay system. Therefore, the purification and characterisation of bioactive metabolites and evaluation of biological activity were conducted. Fractionation of the M. fluvialis extract resulted in the isolation of nine compounds, namely, three fatty acids, (9Z,12Z)-octadecadienoic acid (linoleic acid, 1), (9Z,12Z)-3-hydroxyoctadecadienoic acid (2) and (6Z,9Z)-13-hydroxyoctadecadienoic acid (3); four sterols, stellasterol (4), ergosterol peroxide (5), ergosterol (6) and brassicasterol (7); one sugar alcohol, arabitol (8); and nicotinamide (9). Among them, compounds 2–3 and 7 were first reported from Morchella. In addition, compound 1 exhibited potent α-glucosidase inhibition, with an IC50 value of 14.8 μM. The content of compound 1, the major compound, was 1.2 mg · g–1 extract, as quantitated by HPLC analysis, which was lower than the IC50 value of compound 1. Therefore, M. fluvialis can benefit from diabetes and related diseases through the synergistic effect of linoleic acid (1) and other ingredients.

Published
2023
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11. Characterization of Antioxidant and α-Glucosidase Inhibitory Compounds of Cratoxylum formosum ssp. pruniflorum and Optimization of Extraction Condition

Author

An, Heewon, primary, Thanh, Le Nguyen, additional, Khanh, Le Quoc, additional, Ryu, Se Hwan, additional, Lee, Solip, additional, Yeon, Sang Won, additional, Lee, Hak Hyun, additional, Turk, Ayman, additional, Lee, Ki Yong, additional, Hwang, Bang Yeon, additional, and Lee, Mi Kyeong, additional

Published
2023
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12. Adenosine Deaminase Inhibitory Activity of Medicinal Plants: Boost the Production of Cordycepin in Cordyceps militaris.

Author

Turk, Ayman, Lee, Solip, Yeon, Sang Won, Ryu, Se Hwan, Han, Yoo Kyong, Kim, Young Jun, Ko, Sung Min, Kim, Beom Seok, Hwang, Bang Yeon, Lee, Ki Yong, and Lee, Mi Kyeong

Subjects
ADENOSINE deaminase, MEDICINAL plants, CORDYCEPS, BROWN rice, MOLECULAR docking, DEOXYADENOSINE, ADENOSINES
Abstract

Cordycepin, also known as 3′-deoxyadenosine, is a major active ingredient of Cordyceps militaris with diverse pharmacological effects. Due to its limited supply, many attempts have been conducted to enhance the cordycepin content. As part of this study, eight medicinal plants were supplemented with cultivation substrates of Cordyceps to increase the cordycepin content. Cordyceps cultivated on brown rice supplemented with Mori Folium, Curcumae Rhizoma, Saururi Herba, and Angelicae Gigantis Radix exhibited increased cordycepin content compared to a brown rice control. Among them, the addition of 25% Mori Folium increased the cordycepin content up to 4 times. Adenosine deaminase (ADA) modulates the deamination of adenosine and deoxyadenosine, and the inhibitors have therapeutic potential with anti-proliferative and anti-inflammatory properties. As ADA is also known to be involved in converting cordycepin to 3′-deoxyinosine, the inhibitory activity of medicinal plants on ADA was measured by spectrophotometric analysis using cordycepin as a substrate. As expected, Mori Folium, Curcumae Rhizoma, Saururi Herba, and Angelicae Gigas Radix strongly inhibited ADA activity. Molecular docking analysis also showed the correlation between ADA and the major components of these medicinal plants. Conclusively, our research suggests a new strategy of using medicinal plants to enhance cordycepin production in C. militaris. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Phenylpropanoid-Conjugated Triterpenoids from the Leaves of Actinidia argutaand Their Inhibitory Activity on α-Glucosidase

Author

Ahn, Jong Hoon, Park, Youngki, Yeon, Sang Won, Jo, Yang Hee, Han, Yoo Kyong, Turk, Ayman, Ryu, Se Hwan, Hwang, Bang Yeon, Lee, Ki Yong, and Lee, Mi Kyeong

Abstract

Actinidia arguta, commonly called hardy kiwifruit or kiwiberry, has cold-resistant properties and can be cultivated in Asia, including Korea. Seven new triterpenoids (2–4and 8–11) along with eight known triterpenoids were isolated from the leaves of A. argutathrough various chromatographic techniques. The new triterpenoids were defined as actiniargupenes A–C (2–4), actinidic acid derivatives with phenylpropanoid constituent units, dehydroisoactinidic acid (8), and actiniargupenes D–F (9–11), asiatic acid derivatives with phenylpropanoid substituents, on the basis of 1D and 2D NMR and MS data. Among the triterpenoids, those with a phenylpropanoid constituent unit showed inhibitory activity on α-glucosidase, which suggested the importance of the phenylpropanoid moiety. Molecular docking analysis demonstrated the interaction between the 4′-OH group of the phenylpropanoid moiety and α-glucosidase.

Published
2020
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