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Adenosine Deaminase Inhibitory Activity of Medicinal Plants: Boost the Production of Cordycepin in Cordyceps militaris.

Authors :
Turk, Ayman
Lee, Solip
Yeon, Sang Won
Ryu, Se Hwan
Han, Yoo Kyong
Kim, Young Jun
Ko, Sung Min
Kim, Beom Seok
Hwang, Bang Yeon
Lee, Ki Yong
Lee, Mi Kyeong
Source :
Antioxidants; Jun2023, Vol. 12 Issue 6, p1260, 12p
Publication Year :
2023

Abstract

Cordycepin, also known as 3′-deoxyadenosine, is a major active ingredient of Cordyceps militaris with diverse pharmacological effects. Due to its limited supply, many attempts have been conducted to enhance the cordycepin content. As part of this study, eight medicinal plants were supplemented with cultivation substrates of Cordyceps to increase the cordycepin content. Cordyceps cultivated on brown rice supplemented with Mori Folium, Curcumae Rhizoma, Saururi Herba, and Angelicae Gigantis Radix exhibited increased cordycepin content compared to a brown rice control. Among them, the addition of 25% Mori Folium increased the cordycepin content up to 4 times. Adenosine deaminase (ADA) modulates the deamination of adenosine and deoxyadenosine, and the inhibitors have therapeutic potential with anti-proliferative and anti-inflammatory properties. As ADA is also known to be involved in converting cordycepin to 3′-deoxyinosine, the inhibitory activity of medicinal plants on ADA was measured by spectrophotometric analysis using cordycepin as a substrate. As expected, Mori Folium, Curcumae Rhizoma, Saururi Herba, and Angelicae Gigas Radix strongly inhibited ADA activity. Molecular docking analysis also showed the correlation between ADA and the major components of these medicinal plants. Conclusively, our research suggests a new strategy of using medicinal plants to enhance cordycepin production in C. militaris. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20763921
Volume :
12
Issue :
6
Database :
Complementary Index
Journal :
Antioxidants
Publication Type :
Academic Journal
Accession number :
164577299
Full Text :
https://doi.org/10.3390/antiox12061260