340 results on '"Turchi, John J."'
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2. The mechanistic role of cardiac glycosides in DNA damage response and repair signaling
3. Impact of Optimized Ku–DNA Binding Inhibitors on the Cellular and In Vivo DNA Damage Response.
4. Lung Cancer
5. Abstract A027: Development of small molecule inhibitors of the Ku-DNA interaction: Impacts on NHEJ, DDR signaling, optimizing genome editing technologies, and therapeutic intervention for the treatment of cancer
6. Characterization of Thermally Activated Metalloenediyne Cytotoxicity in Human Melanoma Cells
7. Ku–DNA binding inhibitors modulate the DNA damage response in response to DNA double-strand breaks.
8. ATR inhibition overcomes platinum tolerance associated with ERCC1- and p53-deficiency by inducing replication catastrophe.
9. Small-Molecule Inhibitor Screen for DNA Repair Proteins
10. Supplementary Figure 1 from Novel Irreversible Small Molecule Inhibitors of Replication Protein A Display Single-Agent Activity and Synergize with Cisplatin
11. Data from Novel Irreversible Small Molecule Inhibitors of Replication Protein A Display Single-Agent Activity and Synergize with Cisplatin
12. Supplementary Figure 2 from Novel Irreversible Small Molecule Inhibitors of Replication Protein A Display Single-Agent Activity and Synergize with Cisplatin
13. Data from Platinum-Induced Ubiquitination of Phosphorylated H2AX by RING1A Is Mediated by Replication Protein A in Ovarian Cancer
14. Supplementary Figure 3 from Novel Irreversible Small Molecule Inhibitors of Replication Protein A Display Single-Agent Activity and Synergize with Cisplatin
15. Supplementary Figure S2 from Platinum-Induced Ubiquitination of Phosphorylated H2AX by RING1A Is Mediated by Replication Protein A in Ovarian Cancer
16. Supplementary Figure Legends 1-3 from Novel Irreversible Small Molecule Inhibitors of Replication Protein A Display Single-Agent Activity and Synergize with Cisplatin
17. Supplementary Figures S1-S11 from The Novel, Small-Molecule DNA Methylation Inhibitor SGI-110 as an Ovarian Cancer Chemosensitizer
18. Supplmentary Methods, Tables 1 - 6, Figure Legends from The Novel, Small-Molecule DNA Methylation Inhibitor SGI-110 as an Ovarian Cancer Chemosensitizer
19. Data from Targeted Inhibition of Replication Protein A Reveals Cytotoxic Activity, Synergy with Chemotherapeutic DNA-Damaging Agents, and Insight into Cellular Function
20. Supplementary Methods, Figures 1-2 from Targeted Inhibition of Replication Protein A Reveals Cytotoxic Activity, Synergy with Chemotherapeutic DNA-Damaging Agents, and Insight into Cellular Function
21. Synthesis and Biological Evaluation of Cardiac Glycosides for Cancer Therapy by Targeting the DNA Damage Response
22. Editorial: Targeting DNA repair and the DNA damage response: Beyond the standard PI3 kinase-like kinases
23. Targeting Nucleotide Excision Repair as a Mechanism to Increase Cisplatin Efficacy
24. Abstract 2596: Impact of novel Ku-DNA binding inhibitors on the DNA DSBs-induced DNA damage response
25. Abstract 802: Development of replication protein A (RPA) targeted PROTACs for the treatment of lung and ovarian cancers
26. Extracellular Tissue Transglutaminase Activates Noncanonical NF-κB Signaling and Promotes Metastasis in Ovarian Cancer
27. Recent Advances in the Development of Non-PIKKs Targeting Small Molecule Inhibitors of DNA Double-Strand Break Repair
28. Characterization and initial demonstration of in vivo efficacy of a novel heat-activated metalloenediyne anti-cancer agent
29. In Vivo Targeting Replication Protein A for Cancer Therapy
30. List of Contributors
31. Identification of Mre11 as a Target for Heat Radiosensitization
32. Characterization and initial demonstration of in vivo efficacy of a novel heat-activated metalloenediyne anti-cancer agent
33. Nitric Oxide and Cisplatin Resistance: NO Easy Answers
34. DNA repair targeted therapy: The past or future of cancer treatment?
35. Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
36. Chemical inhibitor targeting the replication protein A–DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer
37. Enzymatic Completion of Mammalian Lagging-Strand DNA Replication
38. A 5' to 3' Exonuclease Functionally Interacts with Calf DNA Polymerase ε
39. Editorial: Targeting DNA repair and the DNA damage response: Beyond the standard PI3 kinaselike kinases.
40. OB-Folds and Genome Maintenance: Targeting Protein–DNA Interactions for Cancer Therapy
41. ATM mediates repression of DNA end-degradation in an ATP-dependent manner
42. Abstract PO-023: Impact of a novel Ku-DNA binding inhibitor on the IR-induced DNA damage response
43. Chemical exhaustion of RPA in cancer treatment
44. Platinum-Induced Ubiquitination of Phosphorylated H2AX by RING1A Is Mediated by Replication Protein A in Ovarian Cancer
45. Targeting the Nucleotide Excision Repair Pathway for Therapeutic Applications
46. Contributors
47. Strand-specific binding of RPA and XPA to damaged duplex DNA
48. TRF1 inhibitis telomere C-strand DNA synthesis in vitro
49. Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku–DNA interaction
50. Discovery and Development of Novel DNA-PK Inhibitors by Targeting the unique Ku-DNA Interaction
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