109 results on '"Tural, Umit"'
Search Results
2. 394. Rumination and Psychosis: Exploring Brooding, Reflection, and Dimensions of Delusions
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Siu, Kari, primary, Tural, Umit, additional, Parincu, Zamfira, additional, Evans, Kathryn T., additional, Iosifescu, Dan V., additional, and Collins, Katherine A., additional
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- 2024
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3. Separate pathways to violent behavior in schizophrenia and in the general population
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Krakowski, Menahem I., Tural, Umit, and Czobor, Pal
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- 2022
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4. A systematic review and network meta-analysis of carbon dioxide provocation in psychiatric disorders
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Tural, Umit and Iosifescu, Dan V.
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- 2021
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5. The Prevalence of Mitral Valve Prolapse in Panic Disorder: A Meta-Analysis
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Tural, Umit and Iosifescu, Dan V.
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- 2019
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6. Efficacy of Transcranial Photobiomodulation on Depressive Symptoms: A Meta-Analysis
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Cho, Yoonju, primary, Tural, Umit, additional, and Iosifescu, Dan V., additional
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- 2023
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7. Prevalence of Childhood Affective disorders in Turkey: An epidemiological study
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Karacetin, Gul, Arman, Ayse Rodopman, Fis, Nese Perdahli, Demirci, Esra, Ozmen, Sevgi, Hesapcioglu, Selma Tural, Oztop, Didem, Tufan, Ali Evren, Tural, Umit, Aktepe, Evrim, Aksu, Hatice, Ardic, Ulku Akyol, Basgul, Senem, Bilac, Oznur, Coskun, Murat, Celik, Gonca Gul, Demirkaya, Sevcan Karakoc, Dursun, Onur Burak, Durukan, Ibrahim, Fidan, Tulin, Gencoglan, Salih, Gokcen, Cem, Gokten, Emel Sari, Gorker, Isık, Gormez, Vahdet, Gundogdu, Ozlem Yildiz, Gurkan, Cihat Kagan, Herguner, Sabri, Kandemir, Hasan, Kilic, Birim Gunay, Kilincaslan, Ayse, Mutluer, Tuba, Nasiroglu, Serhat, Ozcan, Ozlem Ozel, Ozturk, Mucahit, Sapmaz, Sermin Yalin, Suren, Serkan, Sahin, Nilfer, Tahiroglu, Aysegul Yolga, Toros, Fevziye, Unal, Fatih, Vural, Pinar, Yazici, Ipek Percinel, Yazici, Kemal Utku, Yildirim, Veli, Yulaf, Yasemin, Yuce, Murat, Yuksel, Tugba, Akdemir, Devrim, Altun, Hatice, Ayik, Basak, Bilgic, Ayhan, Bozkurt, Ozlem Hekim, Cakir, Emine Demirbas, Ceri, Veysi, Demir, Nagehan Ucok, Dinc, Gulser, Irmak, Mustafa Yasin, Karaman, Dursun, Kinik, Mehmet Fatih, Mazlum, Betul, Memik, Nursu Cakin, Ozdemir, Dilsad Foto, Sinir, Hayati, Tasdelen, Bedia Ince, Taskin, Beril, Ugur, Cagatay, Uran, Pınar, Uysal, Taciser, Uneri, Ozden Sukran, Yilmaz, Savas, Yilmaz, Sultan Seval, Acikel, Burak, Aktas, Huseyin, Alaca, Rumeysa, Alic, Betul Gul, Almbaidheen, Mahmoud, Ari, Fatma Pinar, Aslan, Cihan, Atabay, Ender, Ay, Merve Gunay, Aydemir, Hilal, Ayranci, Gülseda, Babadagi, Zehra, Bayar, Hasan, Bayhan, Pelin Con, Bayram, Ozlem, Bektas, Nese Dikmeer, Berberoglu, Kivanc Kudret, Bostan, Recep, Cakan, Yasemin, Canli, Merve Arici, Cansiz, Mehmet Akif, Ceylan, Cansin, Coskun, Nese, Coskun, Seyma, Demir, Ibrahim, Demir, Nuran, Demirdogen, Esen Yildirim, Dogan, Busra, Donmez, Yunus Emre, Donder, Funda, Efe, Aysegul, Eray, Safak, Erbilgin, Seda, Erden, Semih, Ersoy, Elif Gokce, Eseroglu, Tugba, Firat, Sumeyra Kina, Gok, Ezgi Eynalli, Goksoy, Seyda Celik, Guler, Gulen, Gules, Zafer, Gunay, Gulay, Gunes, Serkan, Gunes, Adem, Guven, Gokcen, Horozcu, Havvana, Irmak, Ayse, Isik, Umit, Kahraman, Ozlem, Kalayci, Bilge Merve, Karaaslan, Umut, Karadag, Mehmet, Kilic, Hilal Tugba, Kilicaslan, Fethiye, Kinay, Duygu, Koc, Esra Bulanik, Kocael, Omer, Mutlu, Rahime Kadir, San, Zejnep, Nalbant, Kevser, Okumus, Nilufer, Ozbek, Fatih, Ozdemir, Fatma Akkus, Ozdemir, Hanife, Ozgur, Borte Gurbuz, Ozkan, Selcuk, Ozyurt, Esra Yildirim, Polat, Berna, Polat, Hatice, Sekmen, Ebru, Sertcelik, Mehmet, Sevgen, Feyza Hatice, Sevince, Oguz, Shamkhalova, Ulker, Suleyman, Funda, Simsek, Nurcan Eren, Tanir, Yasar, Tekden, Mehmet, Temtek, Seyhan, Topal, Melike, Topal, Zehra, Turk, Tugba, Ucar, Halit Necmi, Ucar, Filiz, Uygun, Duygu, Uzun, Necati, Vatansever, Zeynep, Yazgili, Neslihan Gokce, Yildiz, Dilsad Miniksar, Yildiz, Nazike, and Ercan, Eyup Sabri
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- 2018
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8. Comparison of Adiponectin Levels in Anorexia Nervosa, Bulimia Nervosa, Binge-Eating Disorder, Obesity, Constitutional Thinness, and Healthy Controls: A Network Meta-Analysis
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Tural, Umit, primary, Sparpana, Allison, additional, Sullivan, Elizabeth, additional, and Iosifescu, Dan V., additional
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- 2023
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9. 247. Suicidal Ideation and Behavior in Schizophrenia Spectrum Disorders: The Role of Urgency, Dysregulated Behavior, and Depression
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Hoptman, Matthew, primary, Tural, Umit, additional, Collins, Katherine A., additional, Evans, Kathryn T., additional, Irvin, Molly, additional, Sparpana, Allison, additional, Sullivan, Elizabeth, additional, Iosifescu, Dan V., additional, and Parincu, Zamfira, additional
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- 2023
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10. Suicidal ideation and behavior in schizophrenia: The role of negative urgency and psychiatric symptoms
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Hoptman, Matthew J., primary, Tural, Umit, additional, Arnold, Molly S., additional, Collins, Katherine A., additional, Evans, Kathryn T., additional, Irvin, Molly K., additional, Parincu, Zamfira, additional, Rette, Danielle N., additional, Sparpana, Allison M., additional, Sullivan, Elizabeth F., additional, and Iosifescu, Dan V., additional
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- 2023
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11. Efficacy of Transcranial Photobiomodulation on Depressive Symptoms: A Meta-Analysis.
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Yoonju Cho, Tural, Umit, and Iosifescu, Dan V.
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MENTAL depression , *PHOTOBIOMODULATION therapy , *NEUROLOGICAL disorders , *ANTIDEPRESSANTS , *CONFIDENCE intervals - Abstract
Background: Transcranial photobiomodulation (tPBM) is a novel, noninvasive, device-based intervention, which has been tested as a possible treatment for various neurological and psychiatric conditions. Recently, it has been investigated as an innovative treatment for major depressive disorder (MDD). There have been several animal and clinical studies that evaluated the underlying mechanism and the efficacy of its antidepressant effects, but results have been conflicting. Objective: Thus, we conducted the first meta-analysis on effects of tPBM on depressive symptoms. Materials and methods: Thirty original articles on tPBM were retrieved, eight of them met criteria for inclusion to a random effects meta-analysis. Results: tPBM appeared effective in decreasing depressive symptom severity regardless of diagnosis (Hedges’ g = 1.415, p < 0.001, k = 8), but a significant heterogeneity has been found. The meta-analysis of single-arm studies (baseline to endpoint changes) limited to participants with MDD has supported the significant effect of tPBM in reducing the depression severity, without a significant heterogeneity (Hedges’ g = 1.142, 95% confidence interval = 0.780–1.504, z = 6.19, p < 0.001, k = 5). However, the metaanalysis of the few double-blind, sham-controlled studies in MDD has not supported the statistically significant superiority of tPBM over sham (Hedges’ g = 0.499, p = 0.211, k = 3), although a sample size bias is likely present. Conclusions: Overall, this meta-analysis provides weak support for the promising role of tPBM in the treatment of depressive symptoms. Dose finding studies to determine optimal tPBM parameters followed by larger, randomized, sham-controlled studies will be needed to fully demonstrate the antidepressant efficacy of tPBM. [ABSTRACT FROM AUTHOR]
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- 2023
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12. Very Low-Level Transcranial Photobiomodulation for Major Depressive Disorder
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Iosifescu, Dan V., primary, Norton, Richard J., additional, Tural, Umit, additional, Mischoulon, David, additional, Collins, Katherine, additional, McDonald, Erin, additional, Taboada, Luis De, additional, Foster, Simmie, additional, Cusin, Cristina, additional, Yeung, Albert, additional, Clain, Alisabet, additional, Schoenfeld, David, additional, Hamblin, Michael R., additional, and Cassano, Paolo, additional
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- 2022
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13. Adiponectin in anorexia nervosa and its modifiers: A meta‐regression study
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Tural, Umit, primary and Iosifescu, Dan V., additional
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- 2022
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14. Relationships between Diffusion Tensor Imaging and Resting State Functional Connectivity in Patients with Schizophrenia and Healthy Controls: A Preliminary Study
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Hoptman, Matthew J., primary, Tural, Umit, additional, Lim, Kelvin O., additional, Javitt, Daniel C., additional, and Oberlin, Lauren E., additional
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- 2022
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15. Correlation between S100B and severity of depression in MDD: A meta-analysis
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Tural, Umit, primary, Irvin, Molly Kennedy, additional, and Iosifescu, Dan Vlad, additional
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- 2021
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16. Relationships between Diffusion Tensor Imaging and Resting State Functional Connectivity in Patients with Schizophrenia and Healthy Controls: A Preliminary Study
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Hoptman, Matthew J., primary, Tural, Umit, additional, Lim, Kelvin O., additional, Javitt, Daniel C., additional, and Oberlin, Lauren E., additional
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- 2021
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17. Comparison of Sodium Lactate Infusion and Carbon Dioxide Inhalation Panic Provocation Tests: A Meta-analysis
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Tural, Umit, additional and Iosifescu, Dan V., additional
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- 2021
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18. Effect of Impairment on the Prevalence and Comorbidities of Attention Deficit Hyperactivity Disorder in a National Survey: Nation-Wide Prevalence and Comorbidities of ADHD
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Ercan, Eyup Sabri, primary, Unsel-Bolat, Gul, additional, Tufan, Ali Evren, additional, Karakoc Demirkaya, Sevcan, additional, Bilac, Oznur, additional, Celik, Goncagul, additional, Kılıç, Birim Günay, additional, Akyol Ardic, Ulku, additional, Yalin Sapmaz, Sermin, additional, Aksu, Hatice, additional, Yolga Tahiroglu, Aysegul, additional, Karacetin, Gul, additional, Tural, Umit, additional, Aktepe, Evrim, additional, Rodopman Arman, Ayşe, additional, Başgül, Senem, additional, Coşkun, Murat, additional, Dursun, Onur Burak, additional, Durukan, İbrahim, additional, Perdahli Fiş, Neşe, additional, Gençoğlan, Salih, additional, Gökçen, Cem, additional, Sarı Gokten, Emel, additional, Görker, Işık, additional, Görmez, Vahdet, additional, Yıldız Gündoğdu, Özlem, additional, Hesapçioğlu, Selma Tural, additional, Kandemir, Hasan, additional, Mutluer, Tuba, additional, Nasiroğlu, Serhat, additional, Özcan, Özlem, additional, Şahin, Nilfer, additional, Toros, Fevziye, additional, Perçinel Yazici, İpek, additional, Yazici, Kemal Utku, additional, Yulaf, Yasemin, additional, Yüksel, Tuğba, additional, Bilgic, Ayhan, additional, Altun, Hatice, additional, Akdemir, Devrim, additional, Mazlum, Betül, additional, Çakın Memik, Nursu, additional, Foto Özdemir, Dilşad, additional, Üneri, Özden, additional, and Ünal, Fatih, additional
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- 2021
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19. Correlation between S100B and severity of depression in MDD: A meta-analysis.
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Tural, Umit, Irvin, Molly Kennedy, and Iosifescu, Dan Vlad
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MENTAL depression , *RANDOM effects model , *PERCENTILES , *PEARSON correlation (Statistics) , *NEUROGLIA , *PUBLICATION bias - Abstract
Previous studies have demonstrated elevated levels of the S100B protein (located in glial cells) in major depressive disorder (MDD) as compared to healthy controls. However, studies reporting correlation between S100B levels and depression severity have been conflicting. We investigated, through systematic review and meta-analysis, whether the correlation between S100B levels and depression severity is significant in patients with MDD. Pearson correlation coefficients reported in the individual studies were converted to Fisher's Z scores, then pooled using the random effects model. Meta-regression was used to test modifiers of the effect size. Sixteen studies including 658 patients with MDD met eligibility criteria. No publication bias was observed. There was a significant and positive correlation between serum S100B level and depression severity (r = 0.204, z = 2.297, p = 0.022). A meta-regression determined that onset age of MDD and percentage of female participants are significant modifiers of this correlation. A moderate, but non-significant heterogeneity was observed in serum studies (44%). As many studies have reported significantly increased levels of S100B in MDD compared to controls, this meta-analysis supports the assumption that the increase in S100B correlates with the severity of MDD. Additional studies investigating the precise biological connection between S100B and MDD are indicated. [ABSTRACT FROM AUTHOR]
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- 2022
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20. The Importance of Conduct Disorder in the Treatment of Violence in Schizophrenia: Efficacy of Clozapine Compared With Olanzapine and Haloperidol
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Krakowski, Menahem, primary, Tural, Umit, additional, and Czobor, Pál, additional
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- 2021
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21. Comparison of Sodium Lactate Infusion and Carbon Dioxide Inhalation Panic Provocation Tests: A Meta-analysis.
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Tural, Umit and Iosifescu, Dan V.
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PROVOCATION tests (Medicine) , *PANIC attacks , *PANIC disorders , *LACTATES , *SODIUM , *CARBON dioxide - Abstract
Background Sodium lactate (NaL) infusion and carbon dioxide (CO2) inhalation are proven to provoke acute panic attacks (PAs) in patients with panic disorder (PD). A systematic literature search and meta-analysis were performed to compare the effect sizes of these methods. Methods Odds ratios were calculated for each of the original studies and were pooled using the random-effects model. Results Either NaL or CO2 provocations significantly increased the rates of PAs in individuals with PD compared to those in healthy controls. However, the effect size of NaL infusion (OR =25.13, 95% CI =15.48–40.80) was significantly greater than that of CO2 inhalation (OR =10.58, 95%CI =7.88–14.21). Conclusion The evidence for the efficacy of the two panic provocation tests is very strong. Yet, the results support the superiority of NaL infusion over CO2 inhalation challenge as a panic provocation test. Thus, lactate seems a much stronger stimulus than CO2 for the brain suffocation detector. [ABSTRACT FROM AUTHOR]
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- 2022
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22. Effect of Impairment on the Prevalence and Comorbidities of Attention Deficit Hyperactivity Disorder in a National Survey: Nation-Wide Prevalence and Comorbidities of ADHD.
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Ercan, Eyup Sabri, Unsel-Bolat, Gul, Tufan, Ali Evren, Karakoc Demirkaya, Sevcan, Bilac, Oznur, Celik, Goncagul, Kılıç, Birim Günay, Akyol Ardic, Ulku, Yalin Sapmaz, Sermin, Aksu, Hatice, Yolga Tahiroglu, Aysegul, Karacetin, Gul, Tural, Umit, Aktepe, Evrim, Rodopman Arman, Ayşe, Başgül, Senem, Coşkun, Murat, Dursun, Onur Burak, Durukan, İbrahim, and Perdahli Fiş, Neşe
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ATTENTION-deficit hyperactivity disorder ,COMORBIDITY ,BEHAVIOR disorders ,MENTAL illness - Abstract
Objective: This study aimed to determine the prevalence and comorbidities of attention-deficit hyperactivity disorder (ADHD) by evaluating a large-scale nation-wide sample of children. Method: The inclusion criterion was being enrolled as a 2nd, 3rd, or 4th-grade student. A semi-structured diagnostic interview (K-SADS-PL), DSM-IV-Based Screening Scale for Disruptive Behavior Disorders, and assessment of impairment (by both parents and teachers) were applied to 5,842 participants. Results: The prevalence of ADHD was 19.5% without impairment and 12.4% with impairment. Both ADHD with and without impairment groups had similar psychiatric comorbidity rates except for oppositional defiant disorder (ODD) and conduct disorder (CD) diagnoses. Impairment in the ADHD group resulted in significantly higher ODD and CD diagnoses. Conclusion: Even when impairment is not described, other psychiatric disorders accompany the diagnosis of ADHD and may cause impairment in the future. Impairment in the diagnosis of ADHD significantly increases the likelihood of ODD and CD. [ABSTRACT FROM AUTHOR]
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- 2022
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23. Neuropeptide Y in PTSD, MDD and Chronic Stress: A Systemic Review and Meta-Analysis
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Tural, Umit, primary and Iosifescu, Dan V., additional
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- 2020
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24. Can follicular Emmprin and BMP 4 levels predict ICSI outcome?
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Yildiz, Nazike, Topal, Zehra, Turk, Tugba, Okumus, Nilufer, Ozbek, Fatih, FOTO ÖZDEMİR, DİLŞAD, Sekmen, Ebru, Sertcelik, Mehmet, SEVGEN, FEYZA HATİCE, Sevince, Oguz, Tekden, Mehmet, Temtek, Seyhan, Ucar, Halit Necmi, Ucar, Filiz, Uygun, Duygu, Uzun, Necati, Vatansever, Zeynep, YAZGILI KAHVECİ, NESLİHAN GÖKÇE, Yildiz, Dilsat Miniksar, Hesapcioglu, Selma Tural, Arman, Ayse Rodopman, Basgulk, Senem, Bilac, Oznur, COŞKUN, Murat, GÜL ÇELİK, GONCA, GÖKÇEN, CEM, GÖRKER, IŞIK, Gormez, Vahdet, Gurkan, Cihat Kaan, HERGÜNER, SABRİ, Kandemir, Hasan, KILIÇ, BİRİM GÜNAY, Kilincaslan, Ayse, Mutluer, Tuba, NASIROĞLU, SERHAT, Yildirim, Veli, Yulaf, Yasemin, YÜCE, DENİZ, YÜKSEL, TUĞBA, AKDEMİR, DEVRİM, Altun, Hatice, ERCAN, EYÜP SABRİ, Polanczyk, Guilherme, Ardic, Ulku Akyol, Karacetin, Gul, Tufan, Ali Evren, Tural, Umit, Aksu, Hatice, AKTEPE, Evrim, Demirkaya, Sevcan Karakoc, Dursun, Burak Onur, Durukan, Ibrahim, Fidan, Tulin, PERDAHLI FİŞ, NEŞE, Gençoğlan, Salih, Gundogdu, Ozlem Yildiz, ÖZCAN, ÖZLEM, Ozturk, Mucahit, Oztop, Didem, Sapmad, Sermin Yalin, Suren, Serkan, Sahin, Nilfer, YOLGA TAHİROĞLU, AYŞEGÜL, Toros, Fevziye, Unal, Fatih, Vural, Pinar, Yazici, Ipek Percinel, YAZICI, KEMAL UTKU, BİLGİÇ, AYHAN, Bozkurt, Ozlem Hekim, Karaman, Dursun, Kinik, Mehmet Fatih, Mazlum, Betul, ÇAKIN MEMİK, NURSU, Sinir, Hayati, İNCE TAŞDELEN, Bedia, Taskin, Beril, Ugur, Cagatay, Uran, Pinar, Uysal, Taciser, Uneri, Ozden, YILMAZ, SAVAŞ, Almaidan, Mahmut, Ari, Fatma Pinar, Aslan, Cihan, Atabay, Ender, Ay, Merve Gunay, Aydemir, Hilal, Ayik, Basak, Cakir, Emine Demirbas, Ceri, Veysi, Demir, Nagehan Ucok, Dinc, Gulser, Irmak, Mustafa Yasin, YILMAZ, SULTAN SEVAL, Acikel, Burak, Aktas, Huseyin, Alaca, Rumeysa, Alic, Betul Gul, Bayram, Ozlem, DİKMEER BEKTAŞ, NEŞE, Berberoglu, Kivanc Kudret, Bostan, Recep, Canli, Merve Arici, Ceylan, Cansin, Firat, Sumeyra Kina, Gules, Zafer, Gunes, Adem, Gunay, Gulay, Ozgur, Borte Gurbuz, Guven, Gokcen, Goksoy, Seyda Celik, KARADAĞ, MEHMET, Kilic, Hilal Tugba, Ayranci, Gulseda, Babadagi, Zehra, Bayar, Hasan, Bayhan, Pelin Con, Cansiz, Mehmet Akif, Cakan, Yasemin, Demir, Ibrahim, Demir, Nuran, Demirdogen, Esen Yildirim, Dogan, Busra, Donmez, Yunus Emre, Donder, Funda, Efe, Aysegul, ERAY, ŞAFAK, Erbilgin, Seda, Erden, Semih, Ersoy, Elif Gokce, Eseroglu, Tugba, Gok, Ezgi Eynalli, Guler, Gulen, Gunes, Serkan, Horozcu, Havvana, IRMAK, Ayşe, IŞIK, Ümit, KAHRAMAN, Özlem, Kalayci, Bilge Merve, Karaaslan, Umut, KILIÇASLAN, FETHİYE, Kinay, Duygu, Kocael, Omer, Koc, Esra Bulanik, Mutlu, Rahime Kadir, Lushi-San, Zejnep, Nalbant, Kevser, Shamkhalova, Ulker, Ozkan, Selcuk, Ozyurt, Esra Yildirim, Polat, Berna, POLAT, Hatice, Suleyman, Funda, Simsek, Nurcan Eren, Tanir, Yasar, Topal, Melike, Acibadem University Dspace, BULUT, Huri, and İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
- Subjects
Male ,0301 basic medicine ,Pregnancy Rate ,Bone Morphogenetic Protein 7 ,medicine.medical_treatment ,Bone Morphogenetic Protein 2 ,Growth Differentiation Factor 9 ,Oocyte Retrieval ,Bone Morphogenetic Protein 4 ,Intracytoplasmic sperm injection ,0302 clinical medicine ,Pregnancy ,In vitro fertilization ,Follicular phase ,TAKMAZ Ö., Yozgatli D., Ozaltin S., ÖZBAŞLI E., Kocyigit Y., Kuran S. B. , BULUT H., GÜNGÖR M., Buyru F., BAŞTU E., -Can follicular Emmprin and BMP 4 levels predict ICSI outcome?-, JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, cilt.36, ss.1127-1133, 2019 ,Medicine ,Assisted Reproduction Technologies ,Genetics (clinical) ,030219 obstetrics & reproductive medicine ,Obstetrics and Gynecology ,General Medicine ,Bone morphogenetic protein 7 ,embryonic structures ,Female ,Infertility, Female ,Adult ,Fertilization in Vitro ,Follicular fluid ,Growth differentiation factor-9 ,Bone morphogenetic protein ,Andrology ,03 medical and health sciences ,Ovulation Induction ,Genetics ,Humans ,Sperm Injections, Intracytoplasmic ,In vitro fertilisation ,BMP 4 ,business.industry ,medicine.disease ,030104 developmental biology ,Reproductive Medicine ,Oocytes ,Basigin ,Emmprin ,business ,Developmental Biology - Abstract
Ozbasli, Esra/0000-0003-0558-7296; Bulut, Huri/0000-0003-2706-9625; Takmaz, Ozguc/0000-0002-3397-7980; Bastu, Ercan/0000-0003-0810-6195 WOS:000473503000011 PubMed ID: 31065945 PurposeTo evaluate the relationship of clinical pregnancy rates with bone morphogenetic proteins 2-4-7 (BMP 2, 4, 7), growth differentiation factor 9 (GDF 9), and Emmprin levels in follicular fluid of intracytoplasmic sperm injection patients.MethodsFollicular fluid of 77 patients who underwent ICSI procedure was collected during the oocyte retrieval procedure. And follicular fluid levels of BMP 2, BMP 4, BMP 7, GDF 9, and Emmprin (Basigin) were measured and compared for clinical pregnancy rates.ResultsFollicular levels of BMP 4 was significantly higher whereas Emmprin levels were lower in patients who had achieved clinically diagnosed pregnancy compared with those who did not achieve clinical pregnancy after ICSI procedure (P=0.007 and P=0.035, respectively). BMP 2, BMP 7, and GDF 9 levels were comparable for both groups.ConclusionClinical pregnancy rates after ICSI may be associated with follicular fluid levels of Emmprin and BMP 4. Follicular levels of Emmprin and BMP 4 can be used as a marker (as markers for predicting ICSI outcomes) for a better ICSI outcome.
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- 2019
25. Supporting patients with body dissatisfaction: A survey of the experiences and training needs of european multi-disciplinary healthcare professionals
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Williamson, Heidi, Antonelli, Paolo, Bringsen, Asa, Davies, Gareth, Detorre, Davide, Harcourt, Diana, Hedin, Gita, Jurgutis, Arnoldas, Tural, Umit, Ayse, Yalcin, and Persson, Martin
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Centre for Appearance Research ,education ,Formerly Health & Social Sciences ,body image dissatisfaction, health professional, training, body image, visible difference - Abstract
© 2018 The Authors Appearance-related concerns resulting from disfigurement or pressure to conform to beauty ideals, indiscriminately affect patients’ mental and physical health. Healthcare professionals face the challenge of addressing patients’ support needs. Therefore a European University Consortium developed a course to address learning needs. Prior to its design, a study with multi-disciplinary European healthcare professionals was conducted to maximize its relevance and acceptability. Healthcare professionals (n = 718; 48% nurses, 30% doctors, 22% allied health professionals) were surveyed regarding the nature and impact of patients’ appearance concerns, confidence in key areas associated with detecting/addressing concerns, and training/educational needs. Participants reported that this subject is highly relevant and 70% described the psychosocial impact of appearance concerns across the lifespan resulting from disfiguring conditions, disability, neurological disease, ageing and weight/shape dissatisfaction. Participants, irrespective of their experience, self-reported inadequate knowledge regarding appearance-specific care, 87% requested further information and 70% wanted access to an accredited course; barriers deterring participation in training were identified. Healthcare professionals across multiple specialties are caring for patients with a wide-range of appearance concerns that impact on physical and mental health and want to increase their appearance-specific knowledge and expertise. Results have informed training/courses which have the potential to improve patient care and ameliorate health-related outcomes.
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- 2018
26. The prevalence of childhood psychopathology in Turkey: a cross-sectional multicenter nationwide study (EPICPAT-T)
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Ercan, Eyup Sabri, primary, Polanczyk, Guilherme, additional, Akyol Ardıc, Ulku, additional, Yuce, Deniz, additional, Karacetın, Gul, additional, Tufan, Ali Evren, additional, Tural, Umit, additional, Aksu, Hatice, additional, Aktepe, Evrim, additional, Rodopman Arman, Ayşe, additional, Başgül, Senem, additional, Bılac, Oznur, additional, Coşkun, Murat, additional, Celık, Gonca Gul, additional, Karakoc Demırkaya, Sevcan, additional, Dursun, Burak Onur, additional, Durukan, İbrahim, additional, Fidan, Tülin, additional, Perdahlı Fiş, Neşe, additional, Gençoğlan, Salih, additional, Gökçen, Cem, additional, Görker, Işık, additional, Görmez, Vahdet, additional, Gündoğdu, Özlem Yıldız, additional, Gürkan, Cihat Kaan, additional, Hergüner, Sabri, additional, Tural Hesapçıoğlu, Selma, additional, Kandemir, Hasan, additional, Kılıç, Birim Günay, additional, Kılınçaslan, Ayse, additional, Mutluer, Tuba, additional, Nasiroğlu, Serhat, additional, Özel Özcan, Özlem, additional, Öztürk, Mücahit, additional, Öztop, Didem, additional, Yalın Sapmaz, Sermin, additional, Süren, Serkan, additional, Şahin, Nilfer, additional, Yolga Tahıroglu, Aysegul, additional, Toros, Fevziye, additional, Ünal, Fatih, additional, Vural, Pınar, additional, Perçinel Yazıcı, İpek, additional, Yazıcı, Kemal Utku, additional, Yıldırım, Veli, additional, Yulaf, Yasemin, additional, Yüce, Murat, additional, Yüksel, Tuğba, additional, Akdemir, Devrim, additional, Altun, Hatice, additional, Ayık, Başak, additional, Bilgic, Ayhan, additional, Hekim Bozkurt, Özlem, additional, Demirbaş Çakır, Emine, additional, Çeri, Veysi, additional, Üçok Demir, Nagehan, additional, Dinç, Gülser, additional, Irmak, Mustafa Yasin, additional, Karaman, Dursun, additional, Kınık, Mehmet Fatih, additional, Mazlum, Betül, additional, Memik, Nursu Çakın, additional, Foto Özdemir, Dilşad, additional, Sınır, Hayati, additional, Ince Taşdelen, Bedia, additional, Taşkın, Beril, additional, Uğur, Çağatay, additional, Uran, Pınar, additional, Uysal, Taciser, additional, Üneri, Özden, additional, Yilmaz, Savas, additional, Seval Yılmaz, Sultan, additional, Açıkel, Burak, additional, Aktaş, Hüseyin, additional, Alaca, Rümeysa, additional, Alıç, Betül Gül, additional, Almaidan, Mahmut, additional, Arı, Fatma Pınar, additional, Aslan, Cihan, additional, Atabay, Ender, additional, Ay, Merve Günay, additional, Aydemir, Hilal, additional, Ayrancı, Gülseda, additional, Babadagı, Zehra, additional, Bayar, Hasan, additional, Çon Bayhan, Pelin, additional, Bayram, Özlem, additional, Dikmeer Bektaş, Neşe, additional, Berberoğlu, Kıvanç Kudret, additional, Bostan, Recep, additional, Arıcı Canlı, Merve, additional, Cansız, Mehmet Akif, additional, Ceylan, Cansın, additional, Coşkun, Neşe, additional, Coşkun, Seyma, additional, Çakan, Yasemin, additional, Demir, İbrahim, additional, Demir, Nuran, additional, Yıldırım Demirdöğen, Esen, additional, Doğan, Büşra, additional, Dönmez, Yunus Emre, additional, Dönder, Funda, additional, Efe, Ayşegül, additional, Eray, Şafak, additional, Erbilgin, Seda, additional, Erden, Semih, additional, Ersoy, Elif Gökçe, additional, Eseroğlu, Tuğba, additional, Kına Fırat, Sümeyra, additional, Eynallı Gök, Ezgi, additional, Güler, Gülen, additional, Güles, Zafer, additional, Güneş, Serkan, additional, Güneş, Adem, additional, Günay, Gülay, additional, Gürbüz Özgür, Börte, additional, Güven, Gökçen, additional, Çelik Göksoy, Şeyda, additional, Horozcu, Havvana, additional, Irmak, Ayşe, additional, Işık, Ümit, additional, Kahraman, Özlem, additional, Kalaycı, Bilge Merve, additional, Karaaslan, Umut, additional, Karadağ, Mehmet, additional, Kılıc, Hilal Tuğba, additional, Kılıçaslan, Fethiye, additional, Kınay, Duygu, additional, Kocael, Ömer, additional, Bulanık Koç, Esra, additional, Kadir Mutlu, Rahime, additional, Lushi-Şan, Zejnep, additional, Nalbant, Kevser, additional, Okumus, Nilüfer, additional, Özbek, Fatih, additional, Akkuş Özdemir, Fatma, additional, Özdemir, Hanife, additional, Özkan, Selçuk, additional, Yıldırım Özyurt, Esra, additional, Polat, Berna, additional, Polat, Hatice, additional, Sekmen, Ebru, additional, Sertçelik, Mehmet, additional, Sevgen, Feyza Hatice, additional, Sevince, Oğuz, additional, Süleyman, Funda, additional, Shamkhalova, Ülker, additional, Eren Şimşek, Nurcan, additional, Tanır, Yaşar, additional, Tekden, Mehmet, additional, Temtek, Seyhan, additional, Topal, Melike, additional, Topal, Zehra, additional, Türk, Tuğba, additional, Uçar, Halit Necmi, additional, Uçar, Filiz, additional, Uygun, Duygu, additional, Uzun, Necati, additional, Vatansever, Zeynep, additional, Yazgılı, Neslihan Gökçe, additional, Miniksar Yıldız, Dilşat, additional, and Yıldız, Nazike, additional
- Published
- 2019
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27. Prevalance Of Internet Addiction Among Adolescents With Psychiatric Disorders
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Yar, Ahmet, primary, Yildiz Gundogdu, Ozlem, additional, Tural, Umit, additional, and Cakin Memik, Nursu, additional
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- 2019
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28. Analysis of 24-Hour Heart Rate Variability among Panic Disorder Patients without Previous Drug Treatment and Comorbid Disorders
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Gunduz, Nermin, primary, Akpinar Aslan, Esma, additional, Eren, Fatma, additional, Sodan Turan, Hatice, additional, Ozturk, Mustafa, additional, and Tural, Umit, additional
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- 2019
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29. A Meta-Analysis of Efficacy of Carbon Dioxide Inhalation as a Challenge Test in Panic Disorder
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Tural, Umit, primary and Alioglu, Firdevs, additional
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- 2019
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30. Neuropeptide Y in PTSD, MDD, and chronic stress: A systematic review and meta‐analysis.
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Tural, Umit and Iosifescu, Dan V.
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- 2020
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31. Subjective Recovery Assessment Scale
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Yildiz, Mustafa, primary, Erim, Rahsan, additional, Soygur, Haldun, additional, Tural, Umit, additional, Kiras, Fatma, additional, and Gules, Emrah, additional
- Published
- 2018
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32. Development and validation of the Subjective Recovery Assessment Scale for patients with schizophrenia
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Yildiz, Mustafa, primary, Erim, Rahsan, additional, Soygur, Haldun, additional, Tural, Umit, additional, Kiras, Fatma, additional, and Gules, Emrah, additional
- Published
- 2017
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33. 3.12 The Epidemiology of Childhood Psychopathology in Turkey: The Epicpat-T Study
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Ercan, Eyup Sabri, primary, Tural, Umit, additional, Tufan, Evren, additional, Ozturk, Mücahit, additional, Karacetin, Gul, additional, Hergüner, Sabri, additional, Arman, Ayşe, additional, Kılıç, Birim Günay, additional, Toros, Fevziye, additional, Ünal, Fatih, additional, Kılınçaslan, Ayşe, additional, Coskun, Murat, additional, Fiş, Neşe Perdahlı, additional, and Görker, Işık, additional
- Published
- 2017
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34. Development and validation of the Subjective Recovery Assessment Scale for patients with schizophrenia.
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Yildiz, Mustafa, Erim, Rahsan, Soygur, Haldun, Tural, Umit, Kiras, Fatma, and Gules, Emrah
- Published
- 2018
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35. Treatment Approach to Sleep Terror: Two Case Reports
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Sodan Turan, Hatice, primary, Gunduz, Nermin, additional, Polat, Aslihan, additional, and Tural, Umit, additional
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- 2015
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36. Use of N-acetylcysteine in Obsessive-Compulsive and Related Disorders
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Memik, Nursu Cakin, primary, Gundogdu, Ozlem Yildiz, additional, and Tural, Umit, additional
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- 2015
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37. Agomelatine versus Sertraline: An Observational, Open-labeled and 12 Weeks Follow-up Study on Efficacy and Tolerability.
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Akpinar, Esma, Cerit, Cem, Talas, Anil, and Tural, Umit
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SERTRALINE ,ANTIDEPRESSANTS - Abstract
Objective: In this open-labeled, 12 weeks follow-up study, we aimed to compare the efficacy and tolerability of agomelatine with sertraline Methods: The outpatients of adult psychiatry clinic who have a new onset of depression and diagnosed as 'major depressive episode' by clinician according to the Diagnostic and Statistical Manual of Mental Disorders 4th edition and prescribed agomelatine (25 mg/day) or sertraline (50 mg/day) were included in the study. Results: The decline of mean Montgomery-Asberg Depression Rating Scale (MADRS) scores of agomelatine group was significantly higher than the sertraline group at the end of 2nd week; however, the difference was not significant at the end of 3 months. Mean Clinical Global Impression-Improvement scale (CGI--I) scores of agomelatine group was lower than sertraline group at first week. Mean CGI-Severity scale and CGI-I scores were favour to sertraline group at the end of the study. Remission rates were 46.7% for sertraline group and 33.3% for agomelatine group while response rates were 76.7% for both groups. Any patient from agomelatine group dropped-out due to adverse effects. The amount of side effects was also less with agomelatine. Conclusion: Agomelatine has a rapid onset efficacy on depressive symptoms and this can be beneficial for some critical cases. Considering MADRS scores, agomelatine seems to have similar efficacy with sertraline but we also point the need for long term studies since CGI scores were favour to sertraline group at the end of the study. Agomelatine has a favourable tolerability profile both in terms of discontinuation and the amount of side effects compared to sertraline. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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38. Acute Dependency Reaction to Meperidine: A case report.
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Tural, Selin, Tural, Umit, Gercek, Arzu, Konya, Deniz, and Kilic, Turker
- Subjects
- *
INTERVERTEBRAL disk diseases , *OPIOID abuse , *DRUG abuse treatment , *ANALGESIA , *IATROGENIC diseases , *TREATMENT of backaches , *PATIENTS , *PREVENTION - Abstract
Postoperative discitis is a rare and painful complication that may emerge following spine procedures. We present a 34-year-old male patient with postoperative discitis who had been addicted to meperidine during pain relief. Three weeks after routine lumbar discectomy, this patient presented with clinical findings and radiographic imaging consistent with discitis. Meperidine, rate of administration was 1 mg/kg three times a day, was prescribed for his low back pain. After two weeks of opioid therapy an iatrogenic meperidine addiction occurred. Opioid analgesics are helpful for excessive painful conditions as a discitis. Although this case showed us we should be careful when we prescribe opioids. [ABSTRACT FROM AUTHOR]
- Published
- 2010
39. Use of N-acetylcysteine in Obsessive-Compulsive and Related Disorders.
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Cakin Memik, Nursu, Yildiz Gundogdu, Ozlem, and Tural, Umit
- Subjects
- *
MENTAL health services , *OBSESSIVE-compulsive disorder , *ACETYLCYSTEINE , *NEUROBEHAVIORAL disorders , *PSYCHOPHARMACOLOGY , *MEDICAL databases , *THERAPEUTICS - Abstract
Information on the use of N-acetylcysteine (NAC) in neuropsychiatric disorders has increased in recent publications. Although there are positive reports on the use of NAC in obsessive-compulsive and related disorders (OCRD), such data have not yet been validated. This article aims to review the research, case series and case reports that have been published about the use of NAC in OCRD. Research papers and case reports on the use of NAC in OCRD published within the last five years have been reviewed using the search engines of "Pubmed" and "Medline Central" databases. The search was performed by matching the terms "obsessivecompulsive disorder (OCD)", "trichotillomania (TTM)", "nail biting", "skin picking", "hoarding disorder", and "body dysmorphic disorder" with "N-acetylcysteine". The search identified 4 papers on TTM, 3 papers on nail biting behavior, 1 paper on OCD and 1 paper on skin-picking behavior. Three of these papers were doubleblind, placebo-controlled studies and four were case reports/series. The results of 2 papers out of the 7 that we reviewed showed that there was no difference between NAC and placebo, while 5 papers reported that the response to the NAC therapy was positive. We did not find any papers on the use of NAC in either hoarding disorder or body dysmorphic disorder. NAC is thought to be a promising psychopharmacologic agent in OCD, which is defined under OCRD due to its common etiology, similar clinical features and similar response to treatment, as well as in TTM, skin picking and nail biting. The effectiveness of glutamatergic modulators on repetitive behaviors or OCD has increased interest in NAC. Although there are a few studies in the area, many research projects are being planned, with some already in progress (www.clinicaltrials.gov), a fact that emphasizes the importance of NAC in OCRD treatment. NAC has been used in a broad spectrum of conditions such as paracetamol intoxication, doxorubicin cardiotoxicity, ischemia-reperfusion-induced injury of the myocardium, acute respiratory distress syndrome, bronchitis, chemotherapy intoxication and heavy metal intoxication. In recent years, there has been an increase in the number of studies exploring the use of NAC in neuropsychiatric disorders such as schizophrenia, autism, bipolar disorder and OCRD. In this review, we have seen that the results of studies assessing the efficacy of NAC in psychiatric disorders are promising; however, there is a need for further studies to evaluate its mechanism of action, appropriate dose range and duration of treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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40. Relationship of pathologic internet use with social phobia and depression among medical students.
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Telkok, Aybike, Cakir, Ugur, and Tural, Umit
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- *
INTERNET users , *MEDICAL students , *HEALTH occupations students , *SYMPTOMS , *DIGITAL literacy - Abstract
Objective: In this study, it has been aimed to investigate the prevalence of Pathologic Internet Use (PIA) and its relationship with social phobia and depression among medical students. Methods: The sample of the study consists of 437 students attending medical faculty in the academic year 2013-2014. Participants were assessed with socio-demographic form, Young Internet Addiction Scale (YIAS), Beck Depression Inventory (BDI) and Liebowitz Social Phobia Scale (LSPS). Acquired data was analyzed by using chi-square test, Mann-Whitney U test, one-way ANOVA test, Kruskal Wallis test and Spearman's correlation analysis. Results: None of all the participants was found to be a pathologic internet user; however, the risky internet use (RIU) ratio was found to be 5%. There was no significant difference between genders in terms of RIU. Internet usage time per day, Beck Depression Inventory scores and Liebowitz Social Anxiety Scale scores were significantly higher in the RIU group compared to the non-RIU. It has been found that students use the internet most commonly for following social media, listening to music/watching videos and chatting. Males use internet for online gaming more than females while females chat and prepare homework more. No significant correlation was found between YIAS scores and smoking, alcohol use or accommodation situation. Conclusion: Problematic internet use is a common problem among college students. In our study PIA and risky internet use rates were found lower among students of a medical faculty. Risky internet use is related to symptoms of depression and social phobia. Variables related to internet addiction and comorbid psychiatric disorders must be identified in order to define, prevent and treat problematic internet use. [ABSTRACT FROM AUTHOR]
- Published
- 2015
41. Reliability and validity of Turkish Form of Baron Depression Screener for Athletes.
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Polat, Aslihan, Cakir, Ugur, Karabulut, Umit, Tural, Umit, and Baron, David
- Subjects
- *
MENTAL depression , *BECK Depression Inventory , *DIAGNOSIS of mental depression , *CHILDREN'S Depression Inventory , *VARIMAX rotation - Abstract
Objective: This study aimed at studying validity and reliability of the Turkish form of the Baron Depression Screener for Athletes (BDSA), which is the only depression screening tool designed specifically for use with athletes. Method: In total, 100 athletes, 76males and 24 females, participated in the study. Calculation of Cronbach's alpha and item-total correlation coefficiency have been performed to assess the reliability of the Turkish form of BDSA. Explanatory factor analysis and Beck Depression Inventory (BDI) have been used to assess validity of the scale. Results: Item-total score correlations for ten items BDSA vary between 0.12 and 0.53; the median value was 0.31. For overall BDSA, Cronbach's alpha coefficient was found to be α=0.65. Factor analysis was conducted to determine the factor structure of the 10 items of BDSA using direct oblimin principal component analysis with varimax rotation. The factor solution yielded 3 factors with Eigenvalues >1, which explained 50.57% of the variance.. Conclusion: Results showed that the Turkish form of the Baron Depression Screener for Athletes is a valid and reliable instrument to assess depression among athletes speaking the Turkish language. [ABSTRACT FROM AUTHOR]
- Published
- 2015
42. Effect of depression on recovery from PTSD.
- Author
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Tural U, Onder E, and Aker T
- Subjects
- Adult, Comorbidity, Earthquakes, Female, Health Surveys, Humans, Male, Middle Aged, Turkey, Depression physiopathology, Stress Disorders, Post-Traumatic rehabilitation, Survivors psychology
- Abstract
It has been suggested that the treatment strategy needs to be reviewed and changed if depression occurs in patients with posttraumatic stress disorder (PTSD). We analyzed data extracted from the Marmara Epidemiological Survey (MES) which had examined 683 survivors at 3 years after a devastating earthquake. Fifty three cases (40.5%) out of the 131 cases with PTSD had also been diagnosed with MDD. Comorbid PTSD and MDD group has significantly lower rates of recovery from PTSD in comparison to PTSD without MDD (26.4% vs. 47.4% respectively). Rates of past psychiatric disorder and past traumatic experience were significantly more frequent among the comorbid group. Moreover, comorbidity of PTSD and MDD was clearly associated with greater psychological distress, more severe PTSD, and diminished perceived social support. Past psychiatric disorder, General Health Questionnaire (GHQ-12) and Multidimensional Scale of Perceived Social Scale (MSPSS) total scores succeeded in predicting the comorbidity of PTSD and MDD significantly.
- Published
- 2012
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43. Treatment-induced manic switch in the course of unipolar depression can predict bipolarity: cluster analysis based evidence.
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Dumlu K, Orhon Z, Özerdem A, Tural U, Ulaş H, and Tunca Z
- Subjects
- Adult, Antidepressive Agents therapeutic use, Bipolar Disorder diagnosis, Bipolar Disorder psychology, Cluster Analysis, Depression, Depressive Disorder diagnosis, Depressive Disorder psychology, Depressive Disorder, Major drug therapy, Diagnostic and Statistical Manual of Mental Disorders, Female, Humans, Male, Middle Aged, Mood Disorders drug therapy, Retrospective Studies, Antidepressive Agents adverse effects, Bipolar Disorder chemically induced, Bipolar Disorder drug therapy, Depressive Disorder drug therapy
- Abstract
Background: Antidepressants are known to induce manic switch in patients with depression. Treatment-induced mania is not considered as bipolar disorder in DSM IV. The aim of this study was to assess whether clinical characteristics of patients with unipolar depression with a history of treatment-induced mania were similar to those of patients with bipolar disorder., Method: The study included 217 consecutive patients with DSM-IV mood disorders, diagnosed as: bipolar disorder type I (BP-I, n = 58) or type II (BP-II, n = 18) whose first episodes were depression, recurrent (unipolar) major depressive disorder with a history of antidepressant treatment-induced mania (switchers = sUD; n = 61) and without such an event (rUD; n = 80). First, the groups were compared with regard to clinical features and course specifiers using variance and chi-square analysis. Variables that differed significantly between the four groups were included in two-step cluster analysis to explore naturally occurring subgroups in all diagnoses. Subsequently, the relationship between the naturally occurring clusters and pre-defined DSM-IV diagnoses were investigated., Results: Two-step cluster analysis revealed two different naturally occurring groups. Higher severity of depressive episodes, with higher rate of melancholic features, higher number of hospitalization and suicide attempts were represented in one cluster where switchers (77%), bipolar I (94.8%) and II (83.3%) patients clustered together., Conclusion: The findings of this study confirm that treatment-induced mania is a clinical phenomenon that belongs within the bipolar spectrum rather than a coincidental treatment complication, and that it should be placed under "bipolar disorders" in future classification systems., Limitations: The study includes the limitations of any naturalistic retrospective study., (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Published
- 2011
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44. Comparison of alprazolam versus captopril in high blood pressure: a randomized controlled trial.
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Yilmaz S, Pekdemir M, Tural U, and Uygun M
- Subjects
- Blood Pressure drug effects, Female, Humans, Male, Middle Aged, Prospective Studies, Treatment Outcome, Alprazolam therapeutic use, Antihypertensive Agents therapeutic use, Anxiety drug therapy, Anxiety physiopathology, Captopril therapeutic use, Hypertension drug therapy, Hypertension parasitology
- Abstract
Unlabelled: OBJECTIVE. Anxiety is an important cause of acute blood pressure (BP) elevation. However, the role of anxiolysis in this situation is still controversial. In this study, the relationship of anxiety with BP and the effect of anxiolytic treatment on BP were investigated. METHODS. Emergency department (ED) patients with an initial systolic BP (SBP) ≥ 160 mmHg or diastolic BP (DBP) ≥ 100 mmHg but no end organ damage were approached for inclusion in the study. In those consenting to participate, anxiety levels were measured using the State-Trait Anxiety Index (STAI) and Visual Analog Scale for Anxiety (VAS-A). Patients were randomly assigned to receive oral alprazolam 0.5 mg or captopril 25 mg. BP and anxiety levels were measured at baseline and at 1 and 2 h after administration of the study medication. RESULTS. Of 133 patients meeting inclusion criteria, 53 patients agreed to participate. Of these, 27 patients (50.9%) received captopril and 26 patients (49.1%) received alprazolam. The majority of the patients had a high-level trait (96.2%, n = 51) and state anxiety (81.1%, n = 43). The mean SBP and VAS-A values of both patient groups dropped significantly over the 2 h, with no significant difference between the two groups. A significant association between SBP and VAS-A scores was found (F((2,50)) = 6.27, p = 0.004)., Conclusion: A significant association exists between the level of BP and anxiety in hypertensive ED patients. Alprazolam is as effective as captopril in lowering BP in ED patients with an initial SBP > 160 mmHg.
- Published
- 2011
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45. History of suffocation, state-trait anxiety, and anxiety sensitivity in predicting 35% carbon dioxide-induced panic.
- Author
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Monkul ES, Onur E, Tural U, Hatch JP, Alkın T, Yücel B, and Fidaner H
- Subjects
- Adult, Analysis of Variance, Blood Pressure physiology, Female, Humans, Male, Middle Aged, Personality Inventory, Predictive Value of Tests, Respiration, Sensory Thresholds, Severity of Illness Index, Statistics, Nonparametric, Anxiety chemically induced, Asphyxia psychology, Carbon Dioxide adverse effects, Panic Disorder diagnosis
- Abstract
The aim of this study was to examine the effects of history of suffocation, state-trait anxiety, and anxiety sensitivity on response to a 35% carbon dioxide (CO₂) challenge in panic disorder patients, their healthy first-degree relatives and healthy comparisons. Thirty-two patients with panic disorder, 32 first-degree relatives, and 34 healthy volunteers underwent the 35% CO₂ challenge. We assessed baseline anxiety with the Anxiety Sensitivity Index (ASI) and State-Trait Anxiety Inventory (STAI1), and panic symptoms with the Panic Symptom List (PSL III-R). A history of suffocation was associated with greater risk of CO₂ reactivity in the combined sample. Patients had more anxiety sensitivity and state and trait anxiety than relatives and healthy comparisons; the difference between relatives and healthy comparisons was not significant. In female patients, trait anxiety predicted CO₂-induced panic. Having a CO₂-sensitive panic disorder patient as a first-degree relative did not predict CO₂-induced panic in a healthy relative. History of suffocation may be an important predictor of CO₂-induced panic. Trait anxiety may have a gender-specific relation to CO₂ reactivity., (Copyright © 2009 Elsevier Ltd. All rights reserved.)
- Published
- 2010
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46. Clinical and pharmacologic risk factors for neuroleptic malignant syndrome and their association with death.
- Author
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Tural U and Onder E
- Subjects
- Adolescent, Adult, Age Factors, Antipsychotic Agents therapeutic use, Benzodiazepines therapeutic use, Bromocriptine therapeutic use, Data Interpretation, Statistical, Death, Female, Hormone Antagonists therapeutic use, Humans, Male, Mental Disorders drug therapy, Mental Disorders epidemiology, Mental Disorders mortality, Middle Aged, Neuroleptic Malignant Syndrome therapy, Risk Factors, Young Adult, Antipsychotic Agents adverse effects, Neuroleptic Malignant Syndrome epidemiology, Neuroleptic Malignant Syndrome mortality
- Abstract
Aim: The aim of the present study was to evaluate demographics, clinical features, psychiatric diagnoses and prognosis of neuroleptic malignant syndrome (NMS) reported in Turkey, and to assess their association with mortality., Methods: Data on all reported cases of NMS in the Turkish Psychiatric Index between 1985 and 2005 were collected. The type, dosage and administration period of neuroleptics, the clinical and laboratory findings; and prognosis were compared in terms of mortality., Results: Thirty-six patients with a mean age of 33.67 +/- 16.98 years were identified. Fifteen (41.7%) were diagnosed as having schizophrenia or other psychotic disorders and the same number were diagnosed as having affective disorder. Remaining five (13.9%) were diagnosed with other psychiatric disorders and 1 (2.7%) had no psychiatric diagnosis. Twenty-two (61.1%) of the NMS cases were associated with high potency typical neuroleptics. Association between an atypical antipsychotic and NMS has been reported in one case. NMS appeared within 7 days after initiation of the antipsychotic medication in the majority of samples (n = 19, 52.8%). Several combinations of rescue treatments were used in the majority of cases (n = 19, 52.8%), although bromocriptine (n = 22, 61.1%) was the most frequently preferred rescue treatment for NMS. Benzodiazepines were significantly better than the other treatment options in preventing mortality. Five out of the 36 patients (13.9%) with NMS had died. Age was the only significant independent factor that was associated with mortality., Conclusions: Benzodiazepines may be included in the treatment of NMS. The mortality rate due to NMS in Turkey was lower than the previously reported rates from other developing countries.
- Published
- 2010
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47. Does gabapentin lead to early symptom improvement in obsessive-compulsive disorder?
- Author
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Onder E, Tural U, and Gökbakan M
- Subjects
- Administration, Oral, Adolescent, Adult, Amines administration & dosage, Analysis of Variance, Anti-Anxiety Agents administration & dosage, Anti-Anxiety Agents therapeutic use, Cyclohexanecarboxylic Acids administration & dosage, Dose-Response Relationship, Drug, Drug Therapy, Combination, Female, Fluoxetine administration & dosage, Gabapentin, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder pathology, Selective Serotonin Reuptake Inhibitors administration & dosage, Selective Serotonin Reuptake Inhibitors therapeutic use, Treatment Outcome, Young Adult, gamma-Aminobutyric Acid administration & dosage, Amines therapeutic use, Cyclohexanecarboxylic Acids therapeutic use, Fluoxetine therapeutic use, Obsessive-Compulsive Disorder drug therapy, gamma-Aminobutyric Acid therapeutic use
- Abstract
Objective: The aim of this study was to compare efficacy of fluoxetine alone and co-administration of gabapentin and fluoxetine in patients with obsessive compulsive disorder (OCD)., Methods: Forty outpatients with a DSM-IV diagnosis of OCD were randomized to open label treatment, 20 of whom were treated with fluoxetine alone and the remaining 20 with fluoxetine plus gabapentin during 8 weeks. The severity was assessed by Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and Clinical Global Impression (CGI)., Results: Final CGI-I and Y-BOCS scores were not significantly different in both groups. However, in repeated measures ANOVA, compared to fluoxetine group, we found significantly a better improvement in the fluoxetine plus gabapentin group at week 2 by means of YBOCS and CGI-I scores. Comparisons on weeks 4, 6 and 8 revealed no statistical differences between the groups. There was no significant difference of adverse effects between two groups., Conclusions: Adding gabapentin to fluoxetine in the treatment of OCD seems to shorten the time to onset of fluoxetine's anti-obsessive effect without a significant increase in adverse effects. In order to accelerate the clinical response, co-administration of fluoxetine and gabapentin may be a preferable strategy. On the other hand, further controlled studies are needed to support this finding.
- Published
- 2008
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48. Basilar artery blood flow velocity changes in patients with panic disorder following 35% carbon dioxide challenge.
- Author
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Alkin T, Tural U, Onur E, Oztürk V, Monkul ES, and Kutluk K
- Subjects
- Adult, Data Interpretation, Statistical, Female, Humans, Male, Panic Disorder diagnosis, Psychiatric Status Rating Scales, Regional Blood Flow physiology, Selective Serotonin Reuptake Inhibitors therapeutic use, Basilar Artery physiology, Carbon Dioxide, Panic Disorder physiopathology, Panic Disorder psychology
- Abstract
Purpose: We compared the mean basilar artery blood flow velocity (BABFV) between patients with panic disorder and healthy subjects both at rest and immediately following carbon dioxide (CO(2)) challenge, and examined the effects of treatment on BABFV., Methods: Twenty four patients with panic disorder with or without agoraphobia and 12 healthy comparison subjects were studied. Visual Analog Anxiety Scale was used to evaluate the anxiogenic effect of 35% CO(2) inhalation. Mean BABFV was monitored using transcranial Doppler ultrasonography at rest and 10, 20, 30, 60, 90, 120 s after 35% CO(2) challenge both before and after four weeks treatment with paroxetine., Results: The hemodynamic response pattern of basilar artery to CO(2) inhalation was significantly different between two groups. CO(2) rapidly triggered blood flow velocity in basilar artery amongst panic patients but not in healthy comparisons. The mean time to normalization of BABFV was significantly longer in panic patients. Four weeks of treatment with paroxetine led to a significantly reduced mean BABFV after 35% CO(2) inhalation in comparison with pretreatment., Conclusions: Patients with panic disorder had impaired cerebral regulatory mechanisms observed as a change in response characteristics in BABFV in response to CO(2) inhalation. Treatment with paroxetine reduced the increase of BABFV seen in patients after the CO(2) challenge.
- Published
- 2007
- Full Text
- View/download PDF
49. Panic disorder subtypes: further clinical differences.
- Author
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Onur E, Alkin T, and Tural U
- Subjects
- Adult, Agoraphobia classification, Agoraphobia psychology, Anxiety Disorders classification, Anxiety Disorders diagnosis, Anxiety Disorders psychology, Cross-Cultural Comparison, Female, Humans, Language, Male, Middle Aged, Panic Disorder classification, Panic Disorder psychology, Personality Assessment statistics & numerical data, Personality Inventory statistics & numerical data, Psychometrics statistics & numerical data, Reproducibility of Results, Turkey, Agoraphobia diagnosis, Hyperventilation psychology, Panic Disorder diagnosis
- Abstract
Panic disorder (PD) is a heterogeneous phenomenon with respect to symptom profile. Most studies agree that a group of patients with prominent respiratory symptoms emerged as a distinct PD subtype. In this study we compared a range of clinical features associated with PD and agoraphobia in patients with respiratory (RS) and nonrespiratory (NRS) subtypes of PD. The participants were 124 patients with PD (79 women and 45 men), with or without agoraphobia, diagnosed by DSM-IV criteria. Following the observer-rated Panic Disorder Severity Scale assessment, subjects completed self-report measures, including the Anxiety Sensitivity Index (ASI), Panic-Agoraphobia Scale; the Beck Anxiety Inventory; and the Panic-Agoraphobic Spectrum Scale (PAS-SR). Multivariate analysis of variance (MANOVA) showed significant group differences [Pillai's trace = 0.95, F (5, 118)(=)2.48, P = .036]. Patients in RS group had higher mean total scores on the ASI (F = 5.00, df = 1, P = .027) and PAS-SR (F = 11.23, df = 1, P = .001) than patients in NRS group. Also, patients with RS attained higher scores than patients with NRS on four domains of PAS-SR (panic-like symptoms, agoraphobia, separation sensitivity, and reassurance seeking). A descriptive discriminant analysis of the data correctly identified 69.4% of the patient group in general and 86.1% of RS group (Wilks's lambda = 0.87, df = 8, P = .048). The significant discriminating factors of the RS and NRS groups were domains of panic-like symptoms, agoraphobia, separation sensitivity, and reassurance seeking. Our findings suggest that anxiety sensitivity and panic-agoraphobic spectrum symptoms might be particularly relevant to understanding subtypes of PD., (2006 Wiley-Liss, Inc)
- Published
- 2007
- Full Text
- View/download PDF
50. Prevalence of psychiatric disorders three years after the 1999 earthquake in Turkey: Marmara Earthquake Survey (MES).
- Author
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Onder E, Tural U, Aker T, Kiliç C, and Erdoğan S
- Subjects
- Humans, Incidence, Mental Disorders diagnosis, Mental Disorders therapy, Prevalence, Recovery of Function, Stress Disorders, Post-Traumatic diagnosis, Stress Disorders, Post-Traumatic epidemiology, Stress Disorders, Post-Traumatic therapy, Time Factors, Turkey, Disasters, Mental Disorders epidemiology, Surveys and Questionnaires
- Abstract
Background: The objective of the study is to describe the community prevalence of psychiatric disorder, mainly posttraumatic stress disorder (PTSD) and Major Depressive Disorder (MDD) 3 years after a devastating earthquake., Methods: Three years after the Marmara Earthquake, 683 individuals from the epicentre were randomly selected to form a representative sample and were assessed with Composite International Diagnostic Interview (CIDI), General Health Questionnaire (GHQ), Traumatic Stress Symptom Checklist (TSSC) and Beck Depression Inventory (BDI)., Results: The 36 months prevalence of PTSD and MDD after the Marmara Earthquake were 19.2% and 18.7% respectively. The current prevalence of PTSD and MDD in the affected community was found to be 11.7% and 10.5%, respectively. PTSD and MDD were the most prevalent disorders after the disaster and showed a decrease over time. However, only 38.9% of the PTSD cases identified at any time over the 3 years were in remission at the 3rd-year. The co-occurrence of MDD with PTSD resulted in a decrease in the rate of recovery from PTSD. MDD was also the most prevalent disorder accompanying PTSD. Of all the subjects 37.5% with PTSD still met the MDD criteria at the 3rd year postearthquake., Conclusions: In comparison with the data from pre-earthquake national mental health profile, the present study showed that the prevalence of MDD, panic disorder, OCD, GAD, social phobia and special phobias were still higher in the affected region 3 years after the earthquake.
- Published
- 2006
- Full Text
- View/download PDF
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