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Does gabapentin lead to early symptom improvement in obsessive-compulsive disorder?
- Source :
-
European archives of psychiatry and clinical neuroscience [Eur Arch Psychiatry Clin Neurosci] 2008 Sep; Vol. 258 (6), pp. 319-23. Date of Electronic Publication: 2008 Feb 23. - Publication Year :
- 2008
-
Abstract
- Objective: The aim of this study was to compare efficacy of fluoxetine alone and co-administration of gabapentin and fluoxetine in patients with obsessive compulsive disorder (OCD).<br />Methods: Forty outpatients with a DSM-IV diagnosis of OCD were randomized to open label treatment, 20 of whom were treated with fluoxetine alone and the remaining 20 with fluoxetine plus gabapentin during 8 weeks. The severity was assessed by Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and Clinical Global Impression (CGI).<br />Results: Final CGI-I and Y-BOCS scores were not significantly different in both groups. However, in repeated measures ANOVA, compared to fluoxetine group, we found significantly a better improvement in the fluoxetine plus gabapentin group at week 2 by means of YBOCS and CGI-I scores. Comparisons on weeks 4, 6 and 8 revealed no statistical differences between the groups. There was no significant difference of adverse effects between two groups.<br />Conclusions: Adding gabapentin to fluoxetine in the treatment of OCD seems to shorten the time to onset of fluoxetine's anti-obsessive effect without a significant increase in adverse effects. In order to accelerate the clinical response, co-administration of fluoxetine and gabapentin may be a preferable strategy. On the other hand, further controlled studies are needed to support this finding.
- Subjects :
- Administration, Oral
Adolescent
Adult
Amines administration & dosage
Analysis of Variance
Anti-Anxiety Agents administration & dosage
Anti-Anxiety Agents therapeutic use
Cyclohexanecarboxylic Acids administration & dosage
Dose-Response Relationship, Drug
Drug Therapy, Combination
Female
Fluoxetine administration & dosage
Gabapentin
Humans
Male
Middle Aged
Obsessive-Compulsive Disorder pathology
Selective Serotonin Reuptake Inhibitors administration & dosage
Selective Serotonin Reuptake Inhibitors therapeutic use
Treatment Outcome
Young Adult
gamma-Aminobutyric Acid administration & dosage
Amines therapeutic use
Cyclohexanecarboxylic Acids therapeutic use
Fluoxetine therapeutic use
Obsessive-Compulsive Disorder drug therapy
gamma-Aminobutyric Acid therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0940-1334
- Volume :
- 258
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European archives of psychiatry and clinical neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 18297416
- Full Text :
- https://doi.org/10.1007/s00406-007-0798-z