14 results on '"Tuija Mantere"'
Search Results
2. Measurement of the Striatal Dopamine Transporter Density and Heterogeneity in Type 1 Alcoholics Using Human Whole Hemisphere Autoradiography.
- Author
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Erkki Tupala, Jyrki T. Kuikka, Håkan Hall, Kim Bergström, Terttu Särkioja, Pirkko Räsänen, Tuija Mantere, Jukka Hiltunen, Jouko Vepsäläinen, and Jari Tiihonen
- Published
- 2001
- Full Text
- View/download PDF
3. Dopamine D2receptors and transporters in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography
- Author
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Terttu Särkioja, Erkki Tupala, Pirkko Räsänen, Håkan Hall, Kim A. Bergström, Jari Tiihonen, and Tuija Mantere
- Subjects
Medial globus pallidus ,medicine.medical_specialty ,Radiological and Ultrasound Technology ,Chemistry ,Putamen ,Striatum ,Nucleus accumbens ,030227 psychiatry ,03 medical and health sciences ,0302 clinical medicine ,Globus pallidus ,Endocrinology ,nervous system ,Neurology ,Dopamine ,Internal medicine ,Dopamine receptor D2 ,medicine ,Radioligand ,Radiology, Nuclear Medicine and imaging ,Neurology (clinical) ,Anatomy ,Neuroscience ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Increasing evidence implies the involvement of the dopamine (DA) system in the pathogenesis of alcoholism. We measured striatal DA D(2) receptors in Cloninger type 1 and 2 alcoholics by using [(125)I]epidepride in human postmortem whole hemispheric autoradiography (WHA), which provides high-resolution images corresponding to positron emission tomographic (PET) studies. We also evaluated the correlation between transporter and receptor DA binding site densities and putative correlation of [(125)I]epidepride binding between the dorsal striatum and nucleus accumbens. In the type 1 alcoholics, the DA D(2) receptor density was 21.4-32.6% lower in all dorsal striatal structures (caudate, putamen, globus pallidus) when compared with the controls. Type 2 alcoholics had 19.6-21.4% lower binding in other dorsal striatal structures, except medial globus pallidus, where they were not significantly different from controls. The density of DA D(2) receptors and DAT had a significant positive correlation only in the putamen of type 1 alcoholics. The binding of [(125)I]epidepride showed also consistent and statistically significant positive correlation between nucleus accumbens and all dorsal striatal areas in type 1 alcoholics but not in the controls. In the type 2 alcoholics, the correlation was weaker than that observed in the type 1 alcoholics, and no correlation was observed between nucleus accumbens and globus pallidus. Our results show that these two subgroups of alcoholics have stark differences in their DA D(2) receptor binding characteristics. Type 2 alcoholics may have selective deficiency in the dorsal striatum, whereas in limbic structures they may not differ significantly from controls. Moreover, WHA provides a useful tool for detailed mapping of neuronal receptors in healthy as well as diseased brain, and can also be used in radioligand development for PET.
- Published
- 2003
4. Different effect of age on dopamine transporters in the dorsal and ventral striatum of controls and alcoholics
- Author
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Jukka Hiltunen, Håkan Hall, Terttu Särkioja, Erkki Tupala, Jari Tiihonen, Kim A. Bergström, Tuija Mantere, and Pirkko Räsänen
- Subjects
Adult ,Male ,Aging ,medicine.medical_specialty ,Dopamine Plasma Membrane Transport Proteins ,Nerve Tissue Proteins ,Striatum ,Nucleus accumbens ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Dopamine ,Internal medicine ,medicine ,Humans ,10. No inequality ,Aged ,Dopamine transporter ,Membrane Glycoproteins ,biology ,Putamen ,Dopaminergic ,Ventral striatum ,Membrane Transport Proteins ,Middle Aged ,Corpus Striatum ,030227 psychiatry ,Alcoholism ,Endocrinology ,medicine.anatomical_structure ,nervous system ,biology.protein ,Autoradiography ,Female ,Autopsy ,Psychology ,Neuroscience ,030217 neurology & neurosurgery ,medicine.drug - Abstract
It is generally agreed that there is a deterioration in brain dopamine (DA) system with aging. The role of the mesolimbic DA in brain ethanol reinforcement is well established, with nucleus accumbens (NAC) serving as a major terminal area of this system, whereas dorsal striatum is more associated with motor control. The aim of this study was to compare putative age-related alterations of dopamine transporters (DAT) in dorsal and ventral striatum of healthy controls and alcoholics. We studied the effect of age on DAT in caudate (NC), putamen (Pu), and nucleus accumbens (NAC) of eight type 1 and 2 alcoholics and 10 healthy controls by using [(125)I]PE2I as a radioligand for postmortem human whole hemisphere autoradiography. In the type 1 alcoholic group age and DAT density did not correlate significantly with any of the structures studied. The mean densities of DAT declined significantly with age in controls and type 2 alcoholics in dorsal striatum (NC, Pu) (range of correlation coefficient from -0.49 to -0.94), but not statistically significantly in NAC. In type 1 alcoholics the lack of correlation between DAT density and age may indicate a preexisting dopaminergic deficit in this patient group, whereas age-related decline among type 2 alcoholics resembled that of healthy controls. Furthermore, dorsal striatal DAT may be more vulnerable to age-related decline than DAT in NAC. This is supported by the notion that DAT in NAC and dorsal striatum have different molecular weights.
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- 2003
5. Serotonin Transporter Distribution and Density in the Cerebral Cortex of Alcoholic and Nonalcoholic Comparison Subjects: A Whole-Hemisphere Autoradiography Study
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Kim A. Bergström, Jari Tiihonen, Håkan Hall, Pirkko Räsänen, J. C. Callaway, Erkki Tupala, Terttu Särkioja, and Tuija Mantere
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Adult ,Male ,Cingulate cortex ,medicine.medical_specialty ,Adolescent ,Prefrontal Cortex ,Nerve Tissue Proteins ,Citalopram ,Tritium ,Gyrus Cinguli ,Synaptic Transmission ,Reference Values ,Internal medicine ,medicine ,Humans ,Prefrontal cortex ,Serotonin transporter ,Anterior cingulate cortex ,Aged ,Cerebral Cortex ,Serotonin Plasma Membrane Transport Proteins ,Membrane Glycoproteins ,biology ,Membrane Transport Proteins ,Human brain ,Middle Aged ,Affect ,Alcoholism ,Psychiatry and Mental health ,medicine.anatomical_structure ,Endocrinology ,Cerebral cortex ,biology.protein ,Autoradiography ,Female ,Serotonin ,Carrier Proteins ,Psychology ,Neuroscience ,medicine.drug - Abstract
Lesions of the medial prefrontal cortex and dysfunctions in serotonin turnover are two well-established factors associated with impulsive and sociopathic behaviors, but no firm neuroanatomical data have linked these pathophysiological findings. The aims of this study were to identify putative areas in the human brain that are rich in serotonin transporter sites, particularly within the medial prefrontal cortex, and to determine whether serotonin transporter density in this area is altered among alcoholic subjects.Serotonin transporter density was measured among 17 alcoholic and 10 nonalcoholic comparison subjects by postmortem whole-hemisphere autoradiography with [(3)H]citalopram.In the human cerebral cortex, serotonin transporter binding sites were concentrated in the perigenual anterior cingulate cortex. Substantially sparser serotonin transporter density (up to 35%) was observed in the perigenual anterior cingulate cortex of alcoholic subjects in relation to nonalcoholic comparison subjects. After adjustment for age and postmortem delay, this finding remained statistically significant.A lower serotonin transporter density among the alcoholic subjects was observed, specifically in the so-called "affect" region, suggesting an association between ethanol addiction and dysfunctional serotonergic neurotransmission in this area.
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- 2002
6. Measurement of the Striatal Dopamine Transporter Density and Heterogeneity in Type 1 Alcoholics Using Human Whole Hemisphere Autoradiography
- Author
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Pirkko Räsänen, Jyrki T. Kuikka, Erkki Tupala, Jari Tiihonen, Terttu Särkioja, Jukka Hiltunen, Jouko Vepsäläinen, Kim A. Bergström, Tuija Mantere, and Håkan Hall
- Subjects
Male ,Nortropanes ,Cognitive Neuroscience ,Dopamine Plasma Membrane Transport Proteins ,Nerve Tissue Proteins ,Striatum ,Nucleus accumbens ,Reference Values ,Dopamine ,medicine ,Humans ,Dominance, Cerebral ,Receptor ,Membrane Glycoproteins ,medicine.diagnostic_test ,Chemistry ,Putamen ,Membrane Transport Proteins ,Human brain ,Middle Aged ,Corpus Striatum ,Alcoholism ,medicine.anatomical_structure ,nervous system ,Neurology ,Positron emission tomography ,Autoradiography ,Female ,Neuroscience ,medicine.drug - Abstract
Dopaminergic mechanisms are involved in the positive reinforcing and addicting effects of alcohol. Positron emission tomography (PET) and single photon emission tomography (SPET) studies have indicated alterations in striatal dopamine transporters (DAT) and in presynaptic dopamine (DA) function in alcoholics, although also contradictory results have been reported. Normal variations in blood flow, metabolism, and receptor densities are apparently important to brain function. Such variations are known to decrease during pathophysiological processes, such as epilepsy, whereas normal receptor distributions are broadly heterogenous. We evaluated the densities and heterogeneities of striatal DAT in 8 adult-onset, Cloninger type I alcoholics and 10 controls using [125I]N-(3-iodoprop-2E-enyl)-2beta-carbomethoxy-3beta- (4'-methylphenyl)nortropane ([125I]PE2I) as a ligand for human postmortem whole hemisphere autoradiography, which provided high resolution images of the brain when compared with in vivo PET and SPET. The mean density and heterogeneity of DAT were markedly lower in the alcoholics. A significant linear correlation existed between DAT density and heterogeneity, as well as between DAT densities in the nucleus accumbens and in the dorsal striatum (caudate and putamen) in alcoholics, but not consistently in controls. The observed low DAT density and heterogeneity in the dorsal striatum suggest that type 1 alcoholics may have a dysfunctional DA system. These data indicate that human whole hemisphere autoradiography with the analysis of binding heterogeneity may be a relevant tool to measure pathological processes in the brain.
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- 2001
7. Dopamine D2/D3-receptor and transporter densities in nucleus accumbens and amygdala of type 1 and 2 alcoholics
- Author
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Erkki Tupala, Terttu Särkioja, Tuija Mantere, Jukka Hiltunen, Kim A. Bergström, Jari Tiihonen, Pirkko Räsänen, Håkan Hall, and J. C. Callaway
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pyrrolidines ,Nortropanes ,Dopamine ,Dopamine Plasma Membrane Transport Proteins ,Contrast Media ,Nerve Tissue Proteins ,Nucleus accumbens ,Amygdala ,Nucleus Accumbens ,Iodine Radioisotopes ,Radioligand Assay ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Dopamine receptor D3 ,Internal medicine ,medicine ,Humans ,Neurotransmitter ,Receptor ,Molecular Biology ,Membrane Glycoproteins ,Receptors, Dopamine D2 ,Chemistry ,Dopaminergic ,Receptors, Dopamine D3 ,Membrane Transport Proteins ,Alcoholism ,Psychiatry and Mental health ,Endocrinology ,medicine.anatomical_structure ,Benzamides ,Female ,Carrier Proteins ,Neuroscience ,medicine.drug - Abstract
Alcohol acts through mechanisms involving the brain neurotransmitter dopamine (DA) with the nucleus accumbens as the key zone for mediating these effects. We evaluated the densities of DA D(2)/D(3) receptors and transporters in the nucleus accumbens and amygdala of post-mortem human brains by using [(125)l]epidepride and [(125)I]PE2I as radioligands in whole hemispheric autoradiography of Cloninger type 1 and 2 alcoholics and healthy controls. When compared with controls, the mean binding of [(125)I]epidepride to DA D(2)/D(3) receptors was 20% lower in the nucleus accumbens and 41% lower in the amygdala, and [(125)I]PE2I binding to DA transporters in the nucleus accumbens was 39% lower in type 1 alcoholics. These data indicate that dopaminergic functions in these limbic areas may be impaired among type 1 alcoholics, due to the substantially lower number of receptor sites. Our results suggest that such a reduction may result in the chronic overuse of alcohol as an attempt to stimulate DA function.
- Published
- 2001
8. Dopamine D2 receptors and transporters in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography
- Author
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Erkki, Tupala, Håkan, Hall, Kim, Bergström, Tuija, Mantere, Pirkko, Räsänen, Terttu, Särkioja, and Jari, Tiihonen
- Subjects
Adult ,Male ,Analysis of Variance ,Dopamine Plasma Membrane Transport Proteins ,Membrane Glycoproteins ,Adolescent ,Receptors, Dopamine D2 ,Brain ,Membrane Transport Proteins ,Nerve Tissue Proteins ,Middle Aged ,Alcoholism ,nervous system ,Autoradiography ,Humans ,Female ,Research Articles ,Aged ,Protein Binding - Abstract
Increasing evidence implies the involvement of the dopamine (DA) system in the pathogenesis of alcoholism. We measured striatal DA D(2) receptors in Cloninger type 1 and 2 alcoholics by using [(125)I]epidepride in human postmortem whole hemispheric autoradiography (WHA), which provides high‐resolution images corresponding to positron emission tomographic (PET) studies. We also evaluated the correlation between transporter and receptor DA binding site densities and putative correlation of [(125)I]epidepride binding between the dorsal striatum and nucleus accumbens. In the type 1 alcoholics, the DA D(2) receptor density was 21.4–32.6% lower in all dorsal striatal structures (caudate, putamen, globus pallidus) when compared with the controls. Type 2 alcoholics had 19.6–21.4% lower binding in other dorsal striatal structures, except medial globus pallidus, where they were not significantly different from controls. The density of DA D(2) receptors and DAT had a significant positive correlation only in the putamen of type 1 alcoholics. The binding of [(125)I]epidepride showed also consistent and statistically significant positive correlation between nucleus accumbens and all dorsal striatal areas in type 1 alcoholics but not in the controls. In the type 2 alcoholics, the correlation was weaker than that observed in the type 1 alcoholics, and no correlation was observed between nucleus accumbens and globus pallidus. Our results show that these two subgroups of alcoholics have stark differences in their DA D(2) receptor binding characteristics. Type 2 alcoholics may have selective deficiency in the dorsal striatum, whereas in limbic structures they may not differ significantly from controls. Moreover, WHA provides a useful tool for detailed mapping of neuronal receptors in healthy as well as diseased brain, and can also be used in radioligand development for PET. Hum. Brain Mapp. 20:91–102, 2003. © 2003 Wiley‐Liss, Inc.
- Published
- 2003
9. Dopamine receptors and transporters in the brain reward circuits of type 1 and 2 alcoholics measured with human whole hemisphere autoradiography
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Terttu Särkioja, Pirkko Räsänen, Jari Tiihonen, Tuija Mantere, Håkan Hall, and Erkki Tupala
- Subjects
Adult ,Male ,Cognitive Neuroscience ,Nerve Tissue Proteins ,Nucleus accumbens ,Nucleus Accumbens ,03 medical and health sciences ,0302 clinical medicine ,Dopamine receptor D1 ,Reward ,Dopamine receptor D3 ,Dopamine ,Dopamine receptor D2 ,Neural Pathways ,medicine ,Humans ,Tissue Distribution ,Age of Onset ,Dopamine Plasma Membrane Transport Proteins ,Membrane Glycoproteins ,Receptors, Dopamine D2 ,Receptors, Dopamine D1 ,Dopaminergic ,Receptors, Dopamine D3 ,Brain ,Membrane Transport Proteins ,Middle Aged ,Amygdala ,030227 psychiatry ,Substantia Nigra ,Alcoholism ,Neurology ,Dopamine receptor ,Case-Control Studies ,Autoradiography ,Brain stimulation reward ,Female ,Psychology ,Neuroscience ,030217 neurology & neurosurgery ,medicine.drug - Abstract
The role of the dopamine system in brain reward mechanisms and development of substance abuse is well-established with nucleus accumbens as a key structure in mediating these effects. Several studies on alcoholism have indicated defects in dopaminergic neurotransmission and alterations in dopamine receptor densities. However, it has remained unclear if the substance abuse-related dopaminergic defect is specifically associated with a certain receptor subtype. The aim of this study was to compare putative alterations of dopamine D(1,) D(2), and D(3) receptors in nucleus accumbens, amygdala, and substantia nigra among alcoholics and controls. We studied the densities of dopamine D(1) and D(3) receptors in brains of 9 type 1 alcoholics, 8 type 2 alcoholics, and 10 healthy controls by using postmortem human whole hemisphere autoradiography. The mean densities of dopamine D(1) and D(3) receptors were at the same level in all study groups. Combining these with our previous results, our data suggest that among type 1 alcoholics dopamine transporters are lower in nucleus accumbens and dopamine D(2), but not D(1) or D(3) receptors in nucleus accumbens and amygdala. Further, the densities of all these dopamine-binding sites among type 2 alcoholics are at the level of healthy controls. The results suggest that lower dopamine receptor density is specific for D(2) receptor and for type 1 alcoholism, which supports Cloninger's neurogenetic model of two alcoholic subtypes, and indicates the importance of classifying these subgroups separately when issues related to dopaminergic activity are studied.
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- 2003
10. Alcoholics show altered histaminergic neurotransmission in several cortical areas--preliminary report
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Jari Tiihonen, J. Tarhanen, Erkki Tupala, Terttu Särkioja, Leena Tuomisto, Tuija Mantere, K. Alakärppä, and Pirkko Räsänen
- Subjects
Adult ,Male ,medicine.medical_specialty ,Neurology ,Adolescent ,Immunology ,Pharmacology toxicology ,Prefrontal Cortex ,Neurotransmission ,Synaptic Transmission ,Preliminary report ,medicine ,Humans ,Aged ,Pharmacology ,Cerebral Cortex ,Psychiatric Status Rating Scales ,business.industry ,Methylhistamines ,Histaminergic ,Middle Aged ,Alcoholism ,Female ,Autopsy ,Occipital Lobe ,business ,Neuroscience ,Histamine - Published
- 2003
11. Effect of alcohol abuse on human brain histamine and tele-methylhistamine
- Author
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Jari Tiihonen, Leena Tuomisto, Pirkko Räsänen, Erkki Tupala, Terttu Särkioja, J. Tarhanen, Tuija Mantere, and K. Alakärppä
- Subjects
Adult ,Male ,medicine.medical_specialty ,Aging ,Adolescent ,Immunology ,Substantia nigra ,Gas Chromatography-Mass Spectrometry ,chemistry.chemical_compound ,Dopamine ,Internal medicine ,medicine ,Humans ,Neurotransmitter ,5-HT receptor ,Aged ,Pharmacology ,Brain Chemistry ,Sex Characteristics ,Methylhistamines ,Dopaminergic ,Histaminergic ,Human brain ,Middle Aged ,Alcoholism ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Female ,Histamine ,medicine.drug - Abstract
Brain neurotransmitter and receptor systems are altered in animals exhibiting increased ethanol preference; most studies being on brain dopamine and 5-hydroxytryptamine(5HT) systems. The role of histaminergic systems in high ethanol consumption is not well understood. It has been suggested that histaminergic tuberomamillary neurons participate in the inhibitory control of reward functions [1]. Lesions of dopaminergic neurons in the substantia nigra have been shown to disrupt reward-related processes [2]. Thus, it is possible that dopaminergic nigrostriatal and histaminergic tuberomamillary striatal systems may act in a reciprocal fashion to regulate reward functions. Pathophysiological differences in the rat brain histaminergic system have been studied on selectively-bred alcohol-preferring AA rats versus their alcohol-avoiding ANA counterparts. Histamine and its metabolite tele-methylhistamine were measured in brains of these rats. Both have been found in higher concentrations in alcohol-preferring rats [3]. Here we studied if similar changes could be detected in humans abusing alcohol.
- Published
- 2002
12. Dopamine D2 receptors and transporters in type 1 and 2 alcoholics
- Author
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Jari Tiihonen, K. Bergstöm, Terttu Särkioja, Pirkko Räsänen, Tuija Mantere, Erkki Tupala, and Håkan Hall
- Subjects
medicine.medical_specialty ,Chemistry ,Dopaminergic ,D1-like receptor ,Psychiatry and Mental health ,Dopamine receptor D1 ,Endocrinology ,Dopamine receptor ,Dopamine receptor D3 ,D2-like receptor ,Dopamine receptor D2 ,Internal medicine ,medicine ,Endogenous agonist - Published
- 2002
13. Dopamine D2 receptors and transporters in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography.
- Author
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Erkki Tupala, Håkan Hall, Kim Bergström, Tuija Mantere, Pirkko Räsänen, and Terttu Särkioja
- Subjects
DOPAMINE ,ALCOHOLISM ,ADRENERGIC receptors - Abstract
Increasing evidence implies the involvement of the dopamine (DA) system in the pathogenesis of alcoholism. We measured striatal DA D
2 receptors in Cloninger type 1 and 2 alcoholics by using [125 I]epidepride in human postmortem whole hemispheric autoradiography (WHA), which provides high-resolution images corresponding to positron emission tomographic (PET) studies. We also evaluated the correlation between transporter and receptor DA binding site densities and putative correlation of [125 I]epidepride binding between the dorsal striatum and nucleus accumbens. In the type 1 alcoholics, the DA D2 receptor density was 21.432.6% lower in all dorsal striatal structures (caudate, putamen, globus pallidus) when compared with the controls. Type 2 alcoholics had 19.621.4% lower binding in other dorsal striatal structures, except medial globus pallidus, where they were not significantly different from controls. The density of DA D2 receptors and DAT had a significant positive correlation only in the putamen of type 1 alcoholics. The binding of [125 I]epidepride showed also consistent and statistically significant positive correlation between nucleus accumbens and all dorsal striatal areas in type 1 alcoholics but not in the controls. In the type 2 alcoholics, the correlation was weaker than that observed in the type 1 alcoholics, and no correlation was observed between nucleus accumbens and globus pallidus. Our results show that these two subgroups of alcoholics have stark differences in their DA D2 receptor binding characteristics. Type 2 alcoholics may have selective deficiency in the dorsal striatum, whereas in limbic structures they may not differ significantly from controls. Moreover, WHA provides a useful tool for detailed mapping of neuronal receptors in healthy as well as diseased brain, and can also be used in radioligand development for PET. Hum. Brain Mapp. 20:91102, 2003. © 2003 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]- Published
- 2003
- Full Text
- View/download PDF
14. Different effect of age on dopamine transporters in the dorsal and ventral striatum of controls and alcoholics.
- Author
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Erkki Tupala, Håkan Hall, Kim Bergström, Tuija Mantere, Pirkko Räsänen, Terttu Särkioja, and Jukka Hiltunen
- Subjects
DOPAMINE ,PHYSIOLOGICAL aspects of aging ,NEUROTRANSMITTERS ,PEOPLE with alcoholism ,AUTORADIOGRAPHY ,PHYSIOLOGY - Abstract
It is generally agreed that there is a deterioration in brain dopamine (DA) system with aging. The role of the mesolimbic DA in brain ethanol reinforcement is well established, with nucleus accumbens (NAC) serving as a major terminal area of this system, whereas dorsal striatum is more associated with motor control. The aim of this study was to compare putative age-related alterations of dopamine transporters (DAT) in dorsal and ventral striatum of healthy controls and alcoholics. We studied the effect of age on DAT in caudate (NC), putamen (Pu), and nucleus accumbens (NAC) of eight type 1 and 2 alcoholics and 10 healthy controls by using [
125 I]PE2I as a radioligand for postmortem human whole hemisphere autoradiography. In the type 1 alcoholic group age and DAT density did not correlate significantly with any of the structures studied. The mean densities of DAT declined significantly with age in controls and type 2 alcoholics in dorsal striatum (NC, Pu) (range of correlation coefficient from -0.49 to -0.94), but not statistically significantly in NAC. In type 1 alcoholics the lack of correlation between DAT density and age may indicate a preexisting dopaminergic deficit in this patient group, whereas age-related decline among type 2 alcoholics resembled that of healthy controls. Furthermore, dorsal striatal DAT may be more vulnerable to age-related decline than DAT in NAC. This is supported by the notion that DAT in NAC and dorsal striatum have different molecular weights. Synapse 48:205211, 2003. © 2003 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]- Published
- 2003
- Full Text
- View/download PDF
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