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Dopamine D2/D3-receptor and transporter densities in nucleus accumbens and amygdala of type 1 and 2 alcoholics
- Source :
- Molecular Psychiatry. 6:261-267
- Publication Year :
- 2001
- Publisher :
- Springer Science and Business Media LLC, 2001.
-
Abstract
- Alcohol acts through mechanisms involving the brain neurotransmitter dopamine (DA) with the nucleus accumbens as the key zone for mediating these effects. We evaluated the densities of DA D(2)/D(3) receptors and transporters in the nucleus accumbens and amygdala of post-mortem human brains by using [(125)l]epidepride and [(125)I]PE2I as radioligands in whole hemispheric autoradiography of Cloninger type 1 and 2 alcoholics and healthy controls. When compared with controls, the mean binding of [(125)I]epidepride to DA D(2)/D(3) receptors was 20% lower in the nucleus accumbens and 41% lower in the amygdala, and [(125)I]PE2I binding to DA transporters in the nucleus accumbens was 39% lower in type 1 alcoholics. These data indicate that dopaminergic functions in these limbic areas may be impaired among type 1 alcoholics, due to the substantially lower number of receptor sites. Our results suggest that such a reduction may result in the chronic overuse of alcohol as an attempt to stimulate DA function.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pyrrolidines
Nortropanes
Dopamine
Dopamine Plasma Membrane Transport Proteins
Contrast Media
Nerve Tissue Proteins
Nucleus accumbens
Amygdala
Nucleus Accumbens
Iodine Radioisotopes
Radioligand Assay
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Dopamine receptor D3
Internal medicine
medicine
Humans
Neurotransmitter
Receptor
Molecular Biology
Membrane Glycoproteins
Receptors, Dopamine D2
Chemistry
Dopaminergic
Receptors, Dopamine D3
Membrane Transport Proteins
Alcoholism
Psychiatry and Mental health
Endocrinology
medicine.anatomical_structure
Benzamides
Female
Carrier Proteins
Neuroscience
medicine.drug
Subjects
Details
- ISSN :
- 14765578 and 13594184
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Molecular Psychiatry
- Accession number :
- edsair.doi.dedup.....a55f8d1b4f10db444f265a788d7a2cf1