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7. Apple polyphenol extracts prevent damage to human gastric epithelial cells in vitro and to rat gastric mucosa in vivo

Author

Graziani, G, D'Argenio, Tuccillo, C, Loguericio, C, Ritieni, A, Morisco, F, Del Vecchio Blanco, C, Fogliano, V, and Roamno, M

Subjects
Phytochemicals -- Prevention, Phytochemicals -- Research, Gastric mucosa -- Care and treatment, Gastric mucosa -- Research, Apple juice -- Prevention, Apple juice -- Research, Antioxidants -- Prevention, Antioxidants -- Research, Health
Published
2005

10. T06.01.16 EVALUATION OF THE EFFECT DERIVED FROM SILYBIN WITH VITAMIN D AND 3 VITAMIN E ADMINISTRATION ON CLINICAL, METABOLIC, ENDOTHELIAL 4 DYSFUNCTION, OXIDATIVE STRESS PARAMETERS AND SEROLOGICAL WORSENING 5 MARKERS IN NON-ALCOHOLIC FATTY LIVER DISEASE PATIENTS

Author

Dallio, M., primary, Masarone, M., additional, Gravina, A.G., additional, Di Somma, A., additional, Romeo, M., additional, Tuccillo, C., additional, Lama, S., additional, Stiuso, P., additional, Morisco, F., additional, Persico, M., additional, Loguercio, C., additional, and Federico, A., additional

Published
2020
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11. T02.01.9 EFFICACY OF 14-DAY CONCOMITANT THERAPY IN THE ERADICATION OF H. PYLORI INFECTION: COMPARISON WITH 10-DAY CONCOMITANT THERAPY

Author

Gravina, A.G., primary, Zagari, R.M., additional, Nardone, G., additional, Federico, A., additional, Dallio, M., additional, Martorano, M., additional, Mucherino, C., additional, Romiti, A., additional, Avallone, L., additional, Granata, L., additional, Colacino, L., additional, Facchiano, A., additional, Romito, M.R., additional, Tuccillo, C., additional, Sgambato, D., additional, Miranda, A., additional, Loguercio, C., additional, and Romano, M., additional

Published
2020
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12. T06.01.9 THE BISPHENOL A INDUCED WORSENING OF NON-ALCOHOLIC FATTY LIVER DISEASE: A CLINICAL STRATEGY TO ANTAGONIZE THE PROGRESSION OF THE DISEASE

Author

Dallio, M., primary, Gravina, A.G., additional, Masarone, M., additional, Diano, N., additional, Nicolucci, C., additional, Errico, S., additional, Di Sarno, R., additional, Tuccillo, C., additional, Stiuso, P., additional, Morisco, F., additional, Persico, M., additional, Loguercio, C., additional, and Federico, A., additional

Published
2020
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26. Qualitative and quantitative evaluation of gut microbial populations in severely obese patients following bilio-intestinal bypass

Author

Federico, A, Dallio, M, Tolone, S, Gravina, Am, Patrone, Vania, Tuccillo, C, Docimo, L, Romano, M, Morelli, Lorenzo, Loguercio, C., Federico, Alessandro, Dallio, M, Tolone, Salvatore, Gravina, Ag, Patrone, V, Tuccillo, C, Docimo, Ludovico, Romano, Marco, Morelli, L, and Loguercio, C.

Subjects
Bariatric surgery, Microbiota, Settore AGR/16 - MICROBIOLOGIA AGRARIA, Obesity, DGGE, real-time PCR
Published
2015

30. P.01.18 A REAL LIFE OBSERVATIONAL STUDY ON THE ERADICATION OF H. PYLORI INFECTION IN PATIENTS NAÏVE TO TREATMENT USING CONCOMITANT THERAPY OR BISMUTH QUADRUPLE THERAPY (THREE-IN-ONE PILL)

Author

Gravina, A.G., primary, Nardone, G., additional, Miranda, A., additional, Sgambato, D., additional, Rocco, A., additional, Visciola, G., additional, Tuccillo, C., additional, Compare, D., additional, Dallio, M., additional, Granata, L., additional, Romano, L., additional, De Luca, G., additional, Romito, R., additional, Martorano, M., additional, Mucherino, C., additional, Rocco, P., additional, Federico, A., additional, Loguercio, C., additional, and Romano, M., additional

Published
2018
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32. Healing of TNBS-Induced Colitis in the Rat by Peptide HP(2-20)

Author

Romano, M, Gravina, Ag, Federico, A, Tuccillo, C, Miranda, A, Loguercio, C., D'ARGENIO, GIUSEPPE, PREVETE, Nella, DE PAULIS, AMATO, Romano, M, Gravina, Ag, Federico, A, D'Argenio, Giuseppe, Tuccillo, C, Miranda, A, Prevete, Nella, DE PAULIS, Amato, and Loguercio, C.

Published
2014

35. Healing of TNBS-Induced Colitis in the Rat by Peptide HP(2-20)

Author

D'Argenio G., Gravina AG, Tuccillo, C., Mazzone G., Rossi FW, CAPORASO, NICOLA, DE PAULIS, AMATO, Romano M., PREVETE, Nella, W B SAUNDERS CO-ELSEVIER INC, D'Argenio, G., Gravina, Ag, Tuccillo, C., Mazzone, G., Prevete, Nella, Rossi, Fw, Caporaso, Nicola, DE PAULIS, Amato, and Romano, M.

Published
2013

36. PEPTIDE HP 2-20 ACCELERATED HEALING OF TNBS-INDUCED COLITIS IN THE RAT

Author

Gravina AG, D'Argenio G., Romano M, Tuccillo C, Mazzone G, D. Sgambato, F. W. Rossi, PREVETE, Nella, CAPORASO, NICOLA, DE PAULIS, AMATO, Gravina, Ag, D'Argenio, G., Romano, M, Tuccillo, C, Mazzone, G, Prevete, Nella, D., Sgambato, F. W., Rossi, Caporaso, Nicola, and DE PAULIS, Amato

Published
2013

39. Urotensin-II receptor: a new marker for the differentiation and the target in colon cancer?

Author

FEDERICO, Alessandro, ROMANO, Marco, Gravina A. G., DI DOMENICO, Marina, Marra M., Zappavigna S., D’Armiento F. P., Ippolito R., Tuccillo C., Grieco P., Novellino E., LOGUERCIO, Carmelina, CARAGLIA, Michele, Federico, Alessandro, Romano, Marco, Gravina, A. G., DI DOMENICO, Marina, Marra, M., Zappavigna, S., D’Armiento, F. P., Ippolito, R., Tuccillo, C., Grieco, P., Novellino, E., Loguercio, Carmelina, and Caraglia, Michele

Published
2012

40. Apple polyphenols extract (APE) improves colon damage in a rat model of colitis

Author

Giuseppe D'Argenio a, b, Giovanna Mazzone a, Concetta Tuccillo c, Maria T. Ribecco a, Giulia Graziani d, Antonietta G. Gravina c, Sergio Caserta e, f, Stefano Guido e, Vincenzo Fogliano d, Nicola Caporaso a, Marco Romano c, D’Argenio, G., Mazzone, G., Tuccillo, C., Ribecco, Mt, Graziani, G., Gravina, Ag, Caserta, S., Guido, S., Fogliano, V., Caporaso, N., Romano, Marco, D'Argenio, Giuseppe, Mazzone, Giovanna, C., Tuccillo, Ribecco, MARIA TERESA SILVIA, Graziani, Giulia, A. G., Gravina, Caserta, Sergio, Guido, Stefano, Fogliano, Vincenzo, Caporaso, Nicola, and M., Romano

Subjects
Male, Tissue transglutaminase, GASTRIC-MUCOSA, Pharmacology, law.invention, chemistry.chemical_compound, Mice, law, Intestinal Mucosa, medicine.diagnostic_test, biology, Calpain, Gastroenterology, INHIBITOR, Colitis, Ulcerative colitis, medicine.anatomical_structure, Biochemistry, ULCERATIVE-COLITIS, Malus, Rabbits, EXPRESSION, Western blot, Cystamine, GTP-Binding Proteins, medicine, MANAGEMENT, Animals, Rat colitis, Protein Glutamine gamma Glutamyltransferase 2, RNA, Messenger, Rats, Wistar, Fibroblast, Transglutaminases, Hepatology, business.industry, Plant Extracts, Tumor Necrosis Factor-alpha, Apple polyphenols, DINITROBENZENE SULFONIC-ACID, Polyphenols, IN-VITRO, medicine.disease, chemistry, Trinitrobenzenesulfonic Acid, Cyclooxygenase 2, biology.protein, NIH 3T3 Cells, Phytotherapy, business, INFLAMMATORY-BOWEL-DISEASE
Abstract

Background and aim: Searching for alternative therapies that are effective, safe and less expensive of those currently used for ulcerative colitis, we investigated the efficacy of a polyphenol extract from apple in rat colitis. Methods: Rats with trinitrobenzensulphonic acid-induced colitis were treated daily with rectal administration of apple polyphenols 10(-4) M for 14 days. COX-2, TNF-alpha, tissue transglutaminase and calpain in colon mucosa samples were assessed by reverse transcription-polymerase chain reaction and western blot analyses. To ascertain the role of tissue transglutaminase in mucosal healing, wounded rat fibroblasts were incubated with cystamine (a tissue transglutaminase activity inhibitor). Results: Colitis was associated with increased COX-2, TNF-alpha, calpain, and tissue transglutaminase mRNA. The protein expression of COX-2, TNF-alpha and calpain was increased whilst tissue transglutaminase was decreased. Apple extract treatment reduced the severity of colitis (p < 0.05) and restored all the considered biomarkers at the baseline level. Apple polyphenols reduced the degradation of tissue transglutaminase protein occurring through calpain action. Apple polyphenols-treated wounded fibroblast recovered within 24 h showing intense immunoreactivity for tissue transglutaminase. Conclusion: The efficacy of apple extract is mediated by its effects on COX-2 and TNF-alpha. The unbalance between calpain and tissue transglutaminase may play a role in colonic damage and future therapeutic interventions in ulcerative colitis can target this mechanisms. (C) 2012 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Published
2012

42. Nonsteroidal Anti-Inflammatory Drugs inhibit VacA-induced Cell Vacuolation in vitro by Inhibiting Vacuole Genesis

Author

Ricci, V., Manzo, B.A., Sommi, P., Tuccillo, C., Santangelo, M., Fiorucci, S., Zarrilli, R., and Romano, M.

Subjects
Gastric mucosa -- Physiological aspects, Helicobacter pylori -- Physiological aspects, Anti-inflammatory drugs -- Physiological aspects, Health, Physiological aspects
Abstract

V. Ricci [1] B.A. Manzo [2] P. Sommi [1] C. Tuccillo [2] M. Santangelo [3] S. Fiorucci [4] R. Zarrilli [3] M. Romano [2] [3/08] Nonsteroidal Anti-Inflammatory Drugs inhibit VacA-induced [...]

Published
2001

43. Silybin conjugated with phosphatidilcholine and vitamin E improves liver damage in patients with NAFLD: the results of a randomized multicentre double-blind vs placebo trial

Author

Andreone P., Brisc M. C., Chiaramonte M., Floreani A., Freni M. A., Grieco A., Lobello S., Milani S., Okolicsanyi L., Portincasa P., Smedile A., Sporea I., Sorrentino F., Vecchione R., Tuccillo C., Loguercio C., FEDERICO, Alessandro, Andreone, P., Brisc, M. C., Chiaramonte, M., Federico, Alessandro, Floreani, A., Freni, M. A., Grieco, A., Lobello, S., Milani, S., Okolicsanyi, L., Portincasa, P., Smedile, A., Sporea, I., Sorrentino, F., Vecchione, R., Tuccillo, C., and Loguercio, C.

Published
2011

44. Gut microbiota and probiotics in chronic liver diseases

Author

Cesaro C, Tiso A, Del Prete A, Cariello R, Tuccillo C, Cotticelli G, Del Vecchio Blanco C, LOGUERCIO, Carmelina, Cesaro, C, Tiso, A, Del Prete, A, Cariello, R, Tuccillo, C, Cotticelli, G, Del Vecchio Blanco, C, and Loguercio, Carmelina

Published
2011

46. Antitumour efficacy of MEK inhibitors in human lung cancer cells and their derivatives with acquired resistance to different tyrosine kinase inhibitors

Author

MORGILLO, Floriana, Cascone T, D'Aiuto E, MARTINELLI, Erika, TROIANI, Teresa, Saintigny P, DE PALMA, Raffaele, Heymach JV, BERRINO, Liberato, Tuccillo C, CIARDIELLO, Fortunato, Morgillo, Floriana, Cascone, T, D'Aiuto, E, Martinelli, Erika, Troiani, Teresa, Saintigny, P, DE PALMA, Raffaele, Heymach, Jv, Berrino, Liberato, Tuccillo, C, and Ciardiello, Fortunato

Published
2011

48. Il recettore dell’ urotensina: un nuovo marker per il differenziamento ed il target nel cancro del colon?

Author

FEDERICO, Alessandro, DI DOMENICO, Marina, ROMANO, Marco, Marra M., Zappavigna S., Gravina A. G., D’Armiento F. P., Ippolito R., Tuccillo C., Greco P., Novellino E., Loguercio C., Abbruzzese A., CARAGLIA, Michele, Federico, Alessandro, DI DOMENICO, Marina, Romano, Marco, Marra, M., Zappavigna, S., Gravina, A. G., D’Armiento, F. P., Ippolito, R., Tuccillo, C., Greco, P., Novellino, E., Loguercio, C., Abbruzzese, A., and Caraglia, Michele

Published
2011

49. Espressione del recettore dell’urotensina-II nell’adenocarcinoma del colon umano: studi in vitro ed in vivo

Author

FEDERICO, Alessandro, DI DOMENICO, Marina, ROMANO, Marco, Marra M., Zappavigna S., Gravina A. G., D’Armiento F. P., Ippolito R., Tuccillo C., Greco P., Novellino E., Loguercio C., Abbruzzese A., Caaraglia M., Federico, Alessandro, DI DOMENICO, Marina, Romano, Marco, Marra, M., Zappavigna, S., Gravina, A. G., D’Armiento, F. P., Ippolito, R., Tuccillo, C., Greco, P., Novellino, E., Loguercio, C., Abbruzzese, A., and Caaraglia, M.

Published
2011

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