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2. Perioperative Modified FOLFIRINOX for Resectable Pancreatic Cancer: A Nonrandomized Controlled Trial.

Author

Cecchini, Michael, Salem, Ronald R., Robert, Marie, Czerniak, Suzanne, Blaha, Ondrej, Zelterman, Daniel, Rajaei, Moein, Townsend, Jeffrey P., Cai, Guoping, Chowdhury, Sumedha, Yugawa, Deanne, Tseng, Robert, Mejia Arbelaez, Carlos, Jiao, Jingjing, Shroyer, Kenneth, Thumar, Jaykumar, Kortmansky, Jeremy, Zaheer, Wajih, Fischbach, Neal, and Persico, Justin

Published
2024
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3. Disassembly of embryonic keratin filaments promotes pancreatic cancer metastases

Author

Kawalerski, Ryan R., primary, Gonçalves, Mariana Torrente, additional, Pan, Chun-Hao, additional, Tseng, Robert, additional, Roa-Peña, Lucia, additional, Leiton, Cindy V., additional, Torre-Healy, Luke A., additional, Boyle, Taryn, additional, Chowdhury, Sumedha, additional, Snider, Natasha T., additional, Shroyer, Kenneth R., additional, and Escobar-Hoyos, Luisa F., additional

Published
2024
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4. Abstract B085: K17-induced pyrimidine biosynthesis drives chemoresistance in PDAC

Author

Lyu, Yinghuan, primary, Shroyer, Kenneth, additional, Pan, Chun-Hao, additional, Tseng, Robert, additional, Siraj, Md Afjalus, additional, Rajacharya, Girish Halemirle, additional, Chen, Bo, additional, Donnelly, Katie L, additional, Horowitz, Michael, additional, Mejia Arbelaez, Carlos Mauricio, additional, Chowdhury, Sumedha, additional, Oblein, Lyanne, additional, Marchenko, Natalia, additional, Escobar-Hoyos, Luisa, additional, and Singh, Pankaj K., additional

Published
2024
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5. Abstract C075: Altered RNA splicing causes pancreatic cancer and exposes a therapeutic vulnerability

Author

Medici, Natasha Pinto, primary, Saucedo, Diana Martinez, additional, Lee, Danny, additional, Ku, Li-Ting, additional, Tseng, Robert, additional, Shan, Xinning, additional, Chu, Tianyi, additional, Perez-Piñera, Pablo, additional, Cannataro, Vincent, additional, Townsend, Jeffrey, additional, Iacobuzio-Donahue, Christine, additional, Robert, Marie, additional, Abdel-Wahab, Omar, additional, Leach, Steven D., additional, and Escobar-Hoyos, Luisa, additional

Published
2024
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6. Abstract A072: Keratin 17-signature for stratification of chemotherapy in pancreatic adenocarcinoma

Author

Chowdhury, Sumedha, primary, Yugawa, Deanne, additional, Tseng, Robert, additional, Mejia, Mauricio, additional, Lacy, Jill, additional, Patel, Timil, additional, Escobar-Hoyos, Luisa, additional, Shroyer, Kenneth, additional, Cai, Guoping, additional, Robert, Marie, additional, Cecchini, Michael, additional, Kunstman, John, additional, Farrell, James, additional, and Johung, Kimberly, additional

Published
2024
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7. Abstract A002: A phase II study of peri-operative modified FOLFIRINOX in localized pancreatic ductal adenocarcinoma (PDAC)

Author

Cecchini, Michael, primary, Salem, Ronald, additional, Robert, Marie, additional, Czerniak, Suzanne, additional, Rajaei, Moein, additional, Townsend, Jeffrey, additional, Blaha, Ondrej, additional, Zelterman, Daniel, additional, Thumar, Jaykumar, additional, Kortmansky, Jeremy, additional, Zaheer, Wajih, additional, Fischbach, Neal, additional, Persico, Justin, additional, Stein, Stacey, additional, Khan, Sajid, additional, Cha, Charles, additional, Billingsley, Kevin, additional, Kunstman, John, additional, Chowdhury, Sumedha, additional, Tseng, Robert, additional, Mauricio, Carlos, additional, Yugawa, Deanne, additional, Escobar-Hoyos, Luisa, additional, Johung, Kimberly, additional, Wiess, Christina, additional, Spickard, Erik, additional, Aushev, Vasily N., additional, Laliotis, George, additional, Jurdi, Adham, additional, Liu, Minetta C., additional, and Lacy, Jill, additional

Published
2024
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8. Abstract C083: SMNDC1 alters the splicing of ERK to potentiate its activity in pancreatic cancer

Author

Siraj, Md Afjalus, primary, Zhang, Yushan, additional, Chakraborty, Prabir, additional, Tseng, Robert, additional, Ku, Li-Ting, additional, Goda, Grant, additional, Giri, Gilbert, additional, Yugawa, Deanne, additional, Wang, Mathew, additional, Das, Shamik, additional, Dey, Anindya, additional, Dwivedi, Shailendra Dhar, additional, Rao, Geeta, additional, Zhang, Min, additional, Yang, Da, additional, Hossen, Md Nazir, additional, Ding, Wei-Qun, additional, Fung, Kar-Ming, additional, Dominguez, Daniel, additional, Bhattacharya, Resham, additional, Escobar-Hoyos, Luisa, additional, and Mukherjee, Priyabrata, additional

Published
2024
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11. Reversible Charge Transfer Doping in Atomically Thin In2O3by Viologens

Author

Wang, Sung-Tsun, Lin, Yu-Liang, Lee, Lin-Ruei, Chang, Yu-Cheng, Tseng, Robert, Weng, Tzu-Ting, He, Yan-Yi, Pan, Yi-Yu, Chou, Tsung-Te, Chen, Jiun-Tai, and Lien, Der-Hsien

Abstract

Atomically thin oxide semiconductors are emerging as potential materials for their potentiality in monolithic 3D integration and sensor applications. In this study, a charge transfer method employing viologen, an organic compound with exceptional reduction potential among n-type organics, is presented to modulate the carrier concentration in atomically thin In2O3without the need of annealing. This study highlights the critical role of channel thickness on doping efficiency, revealing that viologen charge transfer doping is increasingly pronounced in thinner channels owing to their increased surface-to-volume ratio. Upon viologen doping, an electron sheet density of 6.8 × 1012cm–2is achieved in 2 nm In2O3back gate device while preserving carrier mobility. Moreover, by the modification of the functional groups, viologens can be conveniently removed with acetone and an ultrasonic cleaner, making the viologen treatment a reversible process. Based on this doping scheme, we demonstrate an n-type metal oxide semiconductor inverter with viologen-doped In2O3, exhibiting a voltage gain of 26 at VD= 5 V. This complementary pairing of viologen and In2O3offers ease of control over the carrier concentration, making it suitable for the next-generation electronic applications.

Published
2024
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16. Disassembly of embryonic keratin filaments promotes pancreatic cancer metastases

Author

Kawalerski, Ryan R., primary, Gonçalves, Mariana Torrente, additional, Pan, Chun-Hao, additional, Tseng, Robert, additional, Roa-Peña, Lucia, additional, Leiton, Cindy V., additional, Torre-Healy, Luke A., additional, Boyle, Taryn, additional, Chowdhury, Sumedha, additional, Snider, Natasha T., additional, Shroyer, Kenneth R., additional, and Escobar-Hoyos, Luisa F., additional

Published
2022
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17. Targeting keratin 17-mediated reprogramming of de novo pyrimidine biosynthesis to overcome chemoresistance in pancreatic cancer

Author

Pan, Chun-Hao, primary, Chaika, Nina V., additional, Tseng, Robert, additional, Siraj, Md Afjalus, additional, Chen, Bo, additional, Donnelly, Katie L., additional, Horowitz, Michael, additional, Leiton, Cindy V., additional, Chowdhury, Sumedha, additional, Roa-Peña, Lucia, additional, Oblein, Lyanne, additional, Marchenko, Natalia, additional, Singh, Pankaj K., additional, Shroyer, Kenneth R., additional, and Escobar-Hoyos, Luisa F., additional

Published
2022
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20. Abstract A024: Prognostic effects of different TP53 mutations in pancreatic ductal adenocarcinoma

Author

Carlos M. Mejia Arbelaez, Xining Shan, Tseng Robert, Marie E. Robert, Xiaomei Ma, and Luisa F. Escobar-Hoyos

Subjects
Cancer Research, Oncology
Abstract

Approximately, 70% of pancreatic ductal adenocarcinomas (PDACs) have mutations in the TP53 gene; however, it is still unknown if gain- or loss- of function mutations in TP53 provide differential prognostic value to guide therapy. To fill this gap, we assessed the potential effect of wild-type, missense (gain-of-function) and truncating (loss-of-function) TP53 mutations in patient survival, in two independent clinical cohorts (The Cancer Genome Atlas cohort=141, and the Memorial Sloan Kettering–Integrated Mutation Profiling of Actionable Cancer Targets cohort=376 PDACs). We employed multivariable Cox proportional hazards regression models adjusting for patient demographic (age at diagnosis, sex, race/ethnicity) and tumor characteristics (presence of distant metastasis at diagnosis). Additionally, we conducted stratified analyses by the status of “druggable” (DNA repair gene mutations) and other driver mutations (SMAD4 and CDKN2A genes). We found that PDACs with missense TP53 mutations were associated with a worse patient survival compared to tumors with wild-typeTP53 (HR = 1.47, 95% CI: 1.00-2.17; p=0.051). Similarly, patients with truncating mutations in TP53 had a trend to worse OS (HR=1.11, 95% CI, 0.70-1.76; p=0.654) compared to patients with wild-type TP53, however, these associations were not significant. Furthermore, we found that mutations in DNA repair genes, SMAD4 and CDKN2A genes did not show any prognostic value. Our findings suggest that molecular characterization of specific TP53 mutations may help to determine differences in patient prognosis and potentially guide future clinical management of patients. Citation Format: Carlos M. Mejia Arbelaez, Xining Shan, Tseng Robert, Marie E. Robert, Xiaomei Ma, Luisa F. Escobar-Hoyos. Prognostic effects of different TP53 mutations in pancreatic ductal adenocarcinoma [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer; 2022 Sep 13-16; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2022;82(22 Suppl):Abstract nr A024.

Published
2022

28. CFD Simulation for Propeller Performance under Seaway Wave Condition.

Author

Sing-Kwan Lee, Kai Yu, Hamn-Ching Chen, and Tseng, Robert Kuo-Cheng

Abstract

The article discusses a study that reported an overset grid Computational Fluid Dynamics (CFD) simulation for propeller performance in seaway conditions. It examined the propeller that is operating behind a fixed hull in a seaway condition to show the wave effect on propeller performance. Also performed are numerical calculations for a bare hull case to determine the capability of the overset grid CFD approach.

Published
2010

30. VESSEL REPORT: NEW PANAMAX CONTAINER SHIPS.

Author

TSENG, ROBERT K. C.

Subjects
CONTAINER ships, BUSINESS expansion, INTERNATIONAL trade, PANAMA Canal (Panama)
Abstract

The article offers information on Panamax container ships. With the Panama Canal expansion project, which is projected to double the capacity of the waterway by 2014, new Panamax container carriers of massive proportions are now possible. The increasing trend in container size is due to the influences of international trade, global transportation costs, and economies of scale. Design factors such as minimum ballast water, and higher-strength hatch designs and configurations are discussed.

Published
2011

32. Reversible Charge Transfer Doping in Atomically Thin In 2 O 3 by Viologens.

Author

Wang ST, Lin YL, Lee LR, Chang YC, Tseng R, Weng TT, He YY, Pan YY, Chou TT, Chen JT, and Lien DH

Abstract

Atomically thin oxide semiconductors are emerging as potential materials for their potentiality in monolithic 3D integration and sensor applications. In this study, a charge transfer method employing viologen, an organic compound with exceptional reduction potential among n-type organics, is presented to modulate the carrier concentration in atomically thin In 2 O 3 without the need of annealing. This study highlights the critical role of channel thickness on doping efficiency, revealing that viologen charge transfer doping is increasingly pronounced in thinner channels owing to their increased surface-to-volume ratio. Upon viologen doping, an electron sheet density of 6.8 × 10 12 cm -2 is achieved in 2 nm In 2 O 3 back gate device while preserving carrier mobility. Moreover, by the modification of the functional groups, viologens can be conveniently removed with acetone and an ultrasonic cleaner, making the viologen treatment a reversible process. Based on this doping scheme, we demonstrate an n-type metal oxide semiconductor inverter with viologen-doped In 2 O 3 , exhibiting a voltage gain of 26 at V D = 5 V. This complementary pairing of viologen and In 2 O 3 offers ease of control over the carrier concentration, making it suitable for the next-generation electronic applications.

Published
2024
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33. Dissecting the Oncogenic Roles of Keratin 17 in the Hallmarks of Cancer.

Author

Baraks G, Tseng R, Pan CH, Kasliwal S, Leiton CV, Shroyer KR, and Escobar-Hoyos LF

Subjects
Antineoplastic Agents pharmacology, Carcinogenesis genetics, Humans, Keratin-17 genetics, Keratin-17 metabolism, Neoplasms
Abstract

There is an unmet need to identify and validate tumor-specific therapeutic targets to enable more effective treatments for cancer. Heterogeneity in patient clinical characteristics as well as biological and genetic features of tumors present major challenges for the optimization of therapeutic interventions, including the development of novel and more effective precision medicine. The expression of keratin 17 (K17) is a hallmark of the most aggressive forms of cancer across a wide range of anatomical sites and histological types. K17 correlates with shorter patient survival, predicts resistance to specific chemotherapeutic agents, and harbors functional domains that suggest it could be therapeutically targeted. Here, we explore the role of K17 in the hallmarks of cancer and summarize evidence to date for K17-mediated mechanisms involved in each hallmark, elucidating functional roles that warrant further investigation to guide the development of novel therapeutic strategies., (©2021 The Authors; Published by the American Association for Cancer Research.)

Published
2022
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