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Objective: Analysis of androgen status in men hospitalized with a moderate COVID-19 and its relationship with the severity of the disease., Materials and Methods: The study included 152 males with a confirmed diagnosis of COVID-19 based on the results of a positive PCR for the SARS-CoV-2 virus and/or computed tomography of the lungs hospitalized at the MSU University Clinic due to the moderate and severe COVID-19. Examination of the level of biochemical blood parameters (CRP, creatinine, urea, glucose, total testosterone (T)); CT of the lungs. To objectify the severity of the clinical symptoms, the NEWS2 distress syndrome severity scales and the original scale for assessing the clinical condition of patients with COVID 19 (SHOCS-COVID) were used., Results: The median T level in 152 examined patients was 2.14 [1.21; 3.40] ng/ml. In patients with a T level below the median, the CRP level was more than two times higher, and the D-dimer value was almost two times higher than in patients with T level above median. The duration of treatment in the hospital was longer in men with COVID 19 and an initial T level below the median than in patients with T about the median (13 days vs 10.5 days, p=0.003). Low T level was correlated with lung damage by lung CT. After improving the clinical condition, there was a linear increase in the level of T independent of its initial level., Conclusion: Among men with moderate and severe COVID-19, a decreased testosterone level is detected in 46.7% of cases. Patients with low testosterone levels on admission have more severe COVID-19. A significant increase in testosterone level was observed after successful COVID-19 treatment without any special action regarding testosterone level.

Objective: To analyze the anatomometric characteristics of post-pneumonectomy cavity and their changes at various times after surgery., Material and Methods: The study included 47 patients aged 39-75 years after pneumonectomy (right-sided - 23 cases, left-sided - 24 cases). Computed tomography was performed prior to surgery, in 10-12 days, 6 and 12 months after intervention. Transverse, anteroposterior dimensions, height and volume of pleural cavity were evaluated using CT scans and 3D models., Results: Post-pneumonectomy cavity decreases and changes own shape in postoperative period. Reduction is mainly caused by decrease in its height. The volume of post-pneumonectomy cavity was decreased in early postoperative period by 1.8 times compared to preoperative values (from 3351.5±150.0 cm 3 to 2112.1±152.6 cm 3 on the right side and from 2674.3±125.2 cm 3 to 1460.1±84.1 cm 3 on the left side). After 12 months, this value was reduced by 3.68 times compared to early postoperative period (714.3±100.7 cm 3 on the right and 401.5±42.5 cm 3 on the left). The shape changes consist of flattening and sinus depth reduction. Exudate density was similar throughout a year. The capsule was formed in 74.1% of patients after 12 months. There was no correlation between the cavity reduction and patient constitution., Conclusion: Post-pneumonectomy cavity is a dynamically changing anatomical formation participating in the mechanisms of compensation for changes after pneumonectomy. The most significant collapse of post-pneumonectomy cavity occurs in early postoperative period. Cavity reduction degree does not depend on individual characteristics of patients.

Purpose of the Study: Pay attention endoscopists doctors, oncologists surgeons, gastroenterologists on the ability to detect mioblastoma in the esophagus, as well as to present its endoscopic semiotics., Material and Methods: 32583 A primary esophagogastroduodenoscopy and only one patient S., 39 years old (0.0031%) showed polypoid masses in the lower third of the esophagus. Esophagogastroscopy underwent endoscopy XP iSON system Exera II. Patients underwent clinical evaluation and morphological study of endoscopically resected of education., Results: Patient 39 years old 20.01.2012, in the lower third of the esophagus revealed polypoid formation with a flat, smooth surface covered with a mucous membrane, not different from the surrounding mucosa. Morphologic study after endoscopic resection of the tumor - grainycly cell mioblastoma. When viewed within four years of changes in the mucosa and not detected change in the esophageal wall., Conclusion: Abrikosov tumor in the esophagus is extremely rare localization has exophytic growth after endoscopic rernoval requires regular endoscopic surveillance.

The Aim: to present some information-about the rare primary hypertrophy of the pylorus in adults and a clinical case of a patient with this disease., Materials and Methods: the patient A., 52 years of age, after which clinical-instrumental and laboratory research was diagnosed with infiltrative form of cancer of the pylorus with decompensated stenosis. The used: videothoracoscopy, fluoroscopy, peripheral computer electrogastrogram, local fluorescence spectroscopy. The General blood and urine tests, biochemical blood tests, PCR for the determination of tumor markers., Results: The resection of 2/3 of the stomach Billroth I. histological examination of the pylorus diagnosed with hypertrophy of circular muscle fibers, to a lesser extent, hypertro- phy of the longitudinal fibers with inflammatory changes., Conclusion: in cases of suspected infiltrative form of cancer of the pylorus in adults differential diagnosis it is advisable to include the primary hypertrophy of his.

Aim: To study and compare the results of reconstructive and restoretive operations for strictures and bile duct injuries in patients operated by traditional methods and with the use of microsurgical techniques., Materials and Methods: analysis of 181 and reconstructive restore operations reconstruction works produced on the occasion of strictures (111) and intraoperational damage (16) of the bile ducts, strictures choledocho-duodenal anastomosis and choledochocele (20), congenital cysts of the bile ducts (10), chronic indurative pancreatitis (15), the Fatherof papilla stenosis (5), syndrome Mirizzi 4 types (4). In the formation biliodigestive anastomoses traditional technique applied in 116 patients, microsurgical by 65., Results: a comparative evaluation of results of surgical treatment of patients operated on traditional way and with the use of microsurgery technique showed a reduction in the number of postoperative complications in patients undergoing microsurgical operations, such as the insolvency of the seams biliodigestive anastomosis, hepatic failure, acute cholangitis, stricture of the biliodigestive anastomosis., Conclusion: to improve the results of reconstructive operations on the extrahepatic bile ducts contributes microsurgical techniks, which provides minimal trauma to the tissues, histologically accurate adaptation of homogeneous layers sew bodies, contributes healing of biliodigestive anastomosis primary tension. In the absence of conditions for the imposition of microsurgical bilitigating anastomosis without frame drainage should prima adopt changeable transhepatic drainage as in reconstructive and restorative operations.

Aim: An improvement of the stomach through the development of reconstructive operations results of anatomical - the experimentally study and clinical testing of a series of new microsurgical areflux gastrointestinal anastomosis with sphincter properties., Materials and Methods: The study was performed on 60 animals (dogs) and 52 organocomplexes people dead. 4 A series of experiments, developed new ways to 4 gastro-intestinal anastomosis with sphincter properties gastroduodenostomii way to "end to end" (patent number 2,197,903); pilorosohranyayuschey gastrectomy method (patent number 2,201,714); gastronesteostomy way to "end to side" (patent number 2,201,716); gastroduodenostomii way to the formation of artificial pyloric sphincter (patent number 2,212,195)., Results: Anatomical studies on cadaveric organocomplexes installed, but that the use of the formation of the gastro-intestinal anastomosis of microsurgical techniques and a separate cross-linking methods of internal and external casings of hollow organs without entrainment into the joint mucosa anastomosis gives high.impermeability and durability, retains histotopography linkable tissues. Gastric resection methods developed to form microsurgical gastrojejunal anastomosis and gastro used in clinical practice in 20 patients. Operated patients were examined after 1-6 years after surgery. When gastroscopia they celebrated, good function Form-balanced, the sphincter, the absence of duodenal reflux., Conclusion: The use of microsurgical techniques with gastric resection with the formation of functionally active gastroduodenal and gastrojejunal anastomosis can create gastrointes.inal anastomosis with anti-reflux properties and save the porter, without violating its contractile function, ensures minimum trauma to the tissues, the exact adaptation of the histologic homogeneous layers of the walls of bound bodies.

Objective: To identify criteria of pH-grams to diagnose the severity of esophagitis and preneoplastic complications of GERD., Materials and Methods: 63 patients aged from 18 to 70 with A, B, C degree of GERD, according to the Los Angeles classification and 15 patients with intestinal metaplasia of columnar epithelium and leukoplakia of the stratified squamous epithelium of the esophagogastric transition were examined. For daily intraesophageal pH-monitoring "Gastroscan-24", pH probes manufactured by ZAO NPP "Istok- system", Fryazino (Russia) were used. pH-grams were estimated according for indicators DeMeester. Endoscopy was performed by videoesofagogastroscopes of Evis Exera- system--160 and by the tools company "Olympus" (Japan)., Results: 5 options of pH-grams were selected, each of them may correspond to some degree of esophagitis, preneoplastic changes of the esophageal mucosa, esophageal and extraesophageal manifestations of GERD., Conclusion: Daily pH-monitoring of the esophagus can serve as a screening for the severity of esophagitis, preneoplastic changes of esophagogastric transition, for addressing the need of morphological studies and differential diagnosis of extraesophageal manifestations of GERD.