1. Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut.
- Author
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Howitt MR, Lavoie S, Michaud M, Blum AM, Tran SV, Weinstock JV, Gallini CA, Redding K, Margolskee RF, Osborne LC, Artis D, and Garrett WS
- Subjects
- Animals, Doublecortin-Like Kinases, Eosinophils immunology, Goblet Cells immunology, Helminthiasis immunology, Helminthiasis parasitology, Helminths immunology, Immunity, Mucosal, Interleukin-13 immunology, Interleukin-17 immunology, Intestinal Diseases, Parasitic parasitology, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Protein Serine-Threonine Kinases immunology, Protozoan Infections immunology, Protozoan Infections parasitology, Signal Transduction, Taste, Transducin genetics, Transducin immunology, Tritrichomonas immunology, Chemoreceptor Cells immunology, Intestinal Diseases, Parasitic immunology, Intestinal Mucosa immunology, Intestinal Mucosa parasitology, Microbiota immunology, TRPM Cation Channels immunology
- Abstract
The intestinal epithelium forms an essential barrier between a host and its microbiota. Protozoa and helminths are members of the gut microbiota of mammals, including humans, yet the many ways that gut epithelial cells orchestrate responses to these eukaryotes remain unclear. Here we show that tuft cells, which are taste-chemosensory epithelial cells, accumulate during parasite colonization and infection. Disruption of chemosensory signaling through the loss of TRMP5 abrogates the expansion of tuft cells, goblet cells, eosinophils, and type 2 innate lymphoid cells during parasite colonization. Tuft cells are the primary source of the parasite-induced cytokine interleukin-25, which indirectly induces tuft cell expansion by promoting interleukin-13 production by innate lymphoid cells. Our results identify intestinal tuft cells as critical sentinels in the gut epithelium that promote type 2 immunity in response to intestinal parasites., (Copyright © 2016, American Association for the Advancement of Science.)
- Published
- 2016
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