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2. SARS-CoV-2 omicron (B.1.1.529)-related COVID-19 sequelae in vaccinated and unvaccinated patients with cancer: results from the OnCovid registry

Author

Evans, Joanne S, Swallow, Judith, Hanbury, Georgina, Chung, Chris, Patel, Meera, Dettorre, Gino, Belessiotis, Katherine, Saorise, Dolly, Jones, Eleanor, Apthorp, Eleanor, Moss, Charlotte, Russell, Beth, Townsend, Sarah, Jackson, Amanda, Loizidou, Angela, Piccart, Martine, Pommeret, Fanny, Colomba-Blameble, Emeline, Prat, Aleix, Cruz, Claudia A, Reyes, Roxana, Segui, Elia, Marco-Hernández, Javier, Viladot, Margarita, Harbeck, Nadia, Wuerstlein, Rachel, Henze, Franziska, Mahner, Sven, Felip, Eudald, Scotti, Lorenza, Marrari, Andrea, Grosso, Federica, Fusco, Vittorio, Delfanti, Sara, Rossi, Maura, Zambelli, Alberto, Tondini, Carlo, Chiudinelli, Lorenzo, Franchi, Michela, Libertini, Michela, Provenzano, Salvatore, Generali, Daniele, Grisanti, Salvatore, Baggi, Alice, Tovazzi, Valeria, Ficorella, Corrado, Porzio, Giampiero, Saponara, Maristella, Filetti, Marco, Tucci, Marco, Berardi, Rossana, Cantini, Luca, Paoloni, Francesco, Guida, Annalisa, Bracarda, Sergio, Iglesias, Maria, Sanchez de Torre, Ana, Tagliamento, Marco, Cortellini, Alessio, Tabernero, Josep, Mukherjee, Uma, Salazar, Ramon, Sureda, Anna, Maluquer, Clara, Ferrante, Daniela, Bower, Mark, Sharkey, Rachel, Mirallas, Oriol, Plaja, Andrea, Cucurull, Marc, Mesia, Ricard, Dalla Pria, Alessia, Newsom-Davis, Thomas, Van Hemelrijck, Mieke, Sita-Lumsden, Ailsa, Vincenzi, Bruno, Di Fazio, Giuseppina Rita, Tonini, Giuseppe, Pantano, Francesco, Bertuzzi, Alexia, Rossi, Sabrina, Brunet, Joan, Lambertini, Matteo, Pedrazzoli, Paolo, Biello, Federica, D'Avanzo, Francesca, Lee, Alvin J X, Shawe-Taylor, Marianne, Rogers, Lucy, Murphy, Cian, Cooper, Lee, Andaleeb, Ramis, Khalique, Saira, Bawany, Samira, Ahmed, Sarah, Carmona-García, M Carmen, Fort-Culillas, Roser, Liñan, Raquel, Zoratto, Federica, Rizzo, Gianpiero, Perachino, Marta, Doonga, Kris, Gaidano, Gianluca, Bruna, Riccardo, Patriarca, Andrea, Martinez-Vila, Clara, Pérez Criado, Ignacio, Giusti, Raffaele, Mazzoni, Francesca, Antonuzzo, Lorenzo, Santoro, Armando, Parisi, Alessandro, Queirolo, Paola, Aujayeb, Avinash, Rimassa, Lorenza, Diamantis, Nikolaos, Bertulli, Rossella, Fulgenzi, Claudia A M, D'Alessio, Antonio, Ruiz-Camps, Isabel, Saoudi-Gonzalez, Nadia, Garcia Illescas, David, Medina, Irene, Fox, Laura, Gennari, Alessandra, Aguilar-Company, Juan, and Pinato, David J

Published
2023
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3. Outcomes of the SARS-CoV-2 omicron (B.1.1.529) variant outbreak among vaccinated and unvaccinated patients with cancer in Europe: results from the retrospective, multicentre, OnCovid registry study

Author

Evans, Joanne S, Swallow, Judith, Chung, Chris, Patel, Meera, Dettorre, Gino, Ottaviani, Diego, Chowdhury, Amani, Merry, Eve, Chopra, Neha, Lee, Alvin JX, Sng, Christopher CT, Yu, Tamara, Shawe-Taylor, Marianne, Bain, Hamish DC, Wong, Yien Ning Sophia, Galazi, Myria, Benafif, Sarah, Dileo, Palma, Earnshaw, Irina, Patel, Grisma, Wu, Anjui, Soosaipillai, Gehan, Cooper, Lee, Andaleeb, Ramis, Dolly, Saoirse, Apthorp, Eleanor, Srikandarajah, Krishnie, Jones, Eleanor, Van Hemelrijck, Mieke, Moss, Charlotte, Russell, Beth, Chester, John, Loizidou, Angela, Piccart, Martine, Cruz, Claudia A, Reyes, Roxana, Segui, Elia, Marco-Hernández, Javier, Viladot, Margarita, Eremiev, Simeon, Fort-Culillas, Roser, Garcia, Isabel, Liñan, Raquel, Roqué Lloveras, Ariadna, Harbeck, Nadia, Wuerstlein, Rachel, Henze, Franziska, Mahner, Sven, Felip, Eudald, Pous, Anna, D'Avanzo, Francesca, Scotti, Lorenza, Krengli, Marco, Marrari, Andrea, Delfanti, Sara, Maconi, Antonio, Betti, Marta, Tonini, Giuseppe, Di Fazio, Giuseppina Rita, Tondini, Carlo, Chiudinelli, Lorenzo, Franchi, Michela, Libertini, Michela, Bertulli, Rossella, Baggi, Alice, Tovazzi, Valeria, Ficorella, Corrado, Porzio, Giampiero, Saponara, Maristella, Filetti, Marco, Zoratto, Federica, Paoloni, Francesco, Berardi, Rossana, Guida, Annalisa, Bracarda, Sergio, Iglesias, Maria, Sanchez de Torre, Ana, Tagliamento, Marco, Colomba, Emeline, Pommeret, Fanny, Pinato, David J, Aguilar-Company, Juan, Ferrante, Daniela, Hanbury, Georgina, Bower, Mark, Salazar, Ramon, Mirallas, Oriol, Sureda, Anna, Plaja, Andrea, Cucurull, Marc, Mesia, Ricard, Townsend, Sarah, Jackson, Amanda, Dalla Pria, Alessia, Newsom-Davis, Thomas, Handford, Jasmine, Sita-Lumsden, Ailsa, Vincenzi, Bruno, Bertuzzi, Alexia, Brunet, Joan, Lambertini, Matteo, Maluquer, Clara, Pedrazzoli, Paolo, Biello, Federica, Sinclair, Alasdair, Bawany, Samira, Khalique, Saira, Rossi, Sabrina, Rogers, Lucy, Murphy, Cian, Belessiotis, Katherine, Carmona-García, M Carmen, Sharkey, Rachel, García-Illescas, David, Rizzo, Gianpiero, Perachino, Marta, Saoudi-Gonzalez, Nadia, Doonga, Kris, Fox, Laura, Roldán, Elisa, Gaidano, Gianluca, Ruiz-Camps, Isabel, Bruna, Riccardo, Patriarca, Andrea, Martinez-Vila, Clara, Cantini, Luca, Zambelli, Alberto, Giusti, Raffaele, Mazzoni, Francesca, Caliman, Enrico, Santoro, Armando, Grosso, Federica, Parisi, Alessandro, Queirolo, Paola, Aujayeb, Avinash, Rimassa, Lorenza, Prat, Aleix, Tucci, Marco, Grisanti, Salvatore, Mukherjee, Uma, Diamantis, Nikolaos, Fusco, Vittorio, Generali, Daniele, Provenzano, Salvatore, Gennari, Alessandra, Tabernero, Josep, and Cortellini, Alessio

Published
2022
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4. Merkel Cell Carcinoma

Author

Consoli, Francesca, Tovazzi, Valeria, Battocchio, Simonetta, Vermi, William, Bossi, Paolo, Berruti, Alfredo, Beretta, Giordano, editor, Berruti, Alfredo, editor, Bombardieri, Emilio, editor, Fazio, Nicola, editor, and Goletti, Orlando, editor

Published
2021
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5. Prevalence and impact of COVID-19 sequelae on treatment and survival of patients with cancer who recovered from SARS-CoV-2 infection: evidence from the OnCovid retrospective, multicentre registry study

Author

Swallow, Judith, Chung, Chris, Dettorre, Gino, Chopra, Neha, Lee, Alvin JX, Sng, Christopher CT, Wong, Yien Ning Sophia, Galazi, Myria, Benafif, Sarah, Dileo, Palma, Patel, Grisma, Wu, Anjui, Sinclair, Alasdair, Soosaipillai, Gehan, Jones, Eleanor, Diamantis, Nikolaos, Mukherjee, Uma, Jackson, Amanda, Piccart, Martine, Pommeret, Fanny, Colomba, Johann, Colomba-Blameble, Emeline, Prat, Aleix, Cruz, Claudia A, Reyes, Roxana, Segui, Elia, Marco-Hernández, Javier, Tabernero, Josep, Aguilar-Company, Juan, Ruiz-Camps, Isabel, Fox, Laura, Garcia Illescas, David, Mirallas, Oriol, Roldán, Elisa, Carbó, Anna, Garcia, Isabel, Wuerstlein, Rachel, Mesia, Ricard, Maluquer, Clara, D'Avanzo, Francesca, Tonini, Giuseppe, Provenzano, Salvatore, Tovazzi, Valeria, Ficorella, Corrado, Queirolo, Paola, Giusti, Raffaele, Mazzoni, Francesca, Zoratto, Federica, Tucci, Marco, Berardi, Rossana, Guida, Annalisa, Bracarda, Sergio, Iglesias, Maria, Pinato, David J, Bower, Mark, Scotti, Lorenza, Patel, Meera, Colomba, Emeline, Dolly, Saoirse, Loizidou, Angela, Chester, John, Zambelli, Alberto, Dalla Pria, Alessia, Ottaviani, Diego, Chowdhury, Amani, Merry, Eve, Salazar, Ramon, Bertuzzi, Alexia, Brunet, Joan, Lambertini, Matteo, Tagliamento, Marco, Pous, Anna, Sita-Lumsden, Ailsa, Srikandarajah, Krishnie, Seguí, Elia, Generali, Daniele, Grisanti, Salvatore, Pedrazzoli, Paolo, Rizzo, Gianpiero, Libertini, Michela, Moss, Charlotte, Evans, Joanne S, Russell, Beth, Harbeck, Nadia, Vincenzi, Bruno, Biello, Federica, Bertulli, Rossella, Liñan, Raquel, Rossi, Sabrina, Carmona-García, Maria Carmen, Tondini, Carlo, Baggi, Alice, Fotia, Vittoria, Parisi, Alessandro, Porzio, Giampero, Saponara, Maristella, Cruz, Claudia Andrea, García-Illescas, David, Felip, Eudald, Roqué Lloveras, Ariadna, Sharkey, Rachel, Earnshaw, Irina, Ferrante, Daniela, Gaidano, Gianluca, Patriarca, Andrea, Bruna, Riccardo, Sureda, Anna, Martinez-Vila, Clara, Sanchez de Torre, Ana, Cantini, Luca, Filetti, Marco, Rimassa, Lorenza, Chiudinelli, Lorenzo, Franchi, Michela, Krengli, Marco, Santoro, Armando, Van Hemelrijck, Mieke, Newsom-Davis, Thomas, Gennari, Alessandra, and Cortellini, Alessio

Published
2021
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8. Data from Clinical Portrait of the SARS-CoV-2 Epidemic in European Patients with Cancer

Author

Pinato, David J., primary, Zambelli, Alberto, primary, Aguilar-Company, Juan, primary, Bower, Mark, primary, Sng, Christopher C.T., primary, Salazar, Ramon, primary, Bertuzzi, Alexia, primary, Brunet, Joan, primary, Mesia, Ricard, primary, Seguí, Elia, primary, Biello, Federica, primary, Generali, Daniele, primary, Grisanti, Salvatore, primary, Rizzo, Gianpiero, primary, Libertini, Michela, primary, Maconi, Antonio, primary, Harbeck, Nadia, primary, Vincenzi, Bruno, primary, Bertulli, Rossella, primary, Ottaviani, Diego, primary, Carbó, Anna, primary, Bruna, Riccardo, primary, Benafif, Sarah, primary, Marrari, Andrea, primary, Wuerstlein, Rachel, primary, Carmona-Garcia, M. Carmen, primary, Chopra, Neha, primary, Tondini, Carlo, primary, Mirallas, Oriol, primary, Tovazzi, Valeria, primary, Betti, Marta, primary, Provenzano, Salvatore, primary, Fotia, Vittoria, primary, Cruz, Claudia Andrea, primary, Dalla Pria, Alessia, primary, D'Avanzo, Francesca, primary, Evans, Joanne S., primary, Saoudi-Gonzalez, Nadia, primary, Felip, Eudald, primary, Galazi, Myria, primary, Garcia-Fructuoso, Isabel, primary, Lee, Alvin J.X., primary, Newsom-Davis, Thomas, primary, Patriarca, Andrea, primary, García-Illescas, David, primary, Reyes, Roxana, primary, Dileo, Palma, primary, Sharkey, Rachel, primary, Wong, Yien Ning Sophia, primary, Ferrante, Daniela, primary, Marco-Hernández, Javier, primary, Sureda, Anna, primary, Maluquer, Clara, primary, Ruiz-Camps, Isabel, primary, Gaidano, Gianluca, primary, Rimassa, Lorenza, primary, Chiudinelli, Lorenzo, primary, Izuzquiza, Macarena, primary, Cabirta, Alba, primary, Franchi, Michela, primary, Santoro, Armando, primary, Prat, Aleix, primary, Tabernero, Josep, primary, Gennari, Alessandra, primary, Avanzi, Gian Carlo, primary, Bellan, Mattia, primary, Castello, Luigi Mario, primary, Martinez, Maria, primary, Mollà, Meritxell, primary, Pirisi, Mario, primary, Scotti, Lorenza, primary, and Swallow, Judith, primary

Published
2023
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9. Supplementary Data from Clinical Portrait of the SARS-CoV-2 Epidemic in European Patients with Cancer

Author

Pinato, David J., primary, Zambelli, Alberto, primary, Aguilar-Company, Juan, primary, Bower, Mark, primary, Sng, Christopher C.T., primary, Salazar, Ramon, primary, Bertuzzi, Alexia, primary, Brunet, Joan, primary, Mesia, Ricard, primary, Seguí, Elia, primary, Biello, Federica, primary, Generali, Daniele, primary, Grisanti, Salvatore, primary, Rizzo, Gianpiero, primary, Libertini, Michela, primary, Maconi, Antonio, primary, Harbeck, Nadia, primary, Vincenzi, Bruno, primary, Bertulli, Rossella, primary, Ottaviani, Diego, primary, Carbó, Anna, primary, Bruna, Riccardo, primary, Benafif, Sarah, primary, Marrari, Andrea, primary, Wuerstlein, Rachel, primary, Carmona-Garcia, M. Carmen, primary, Chopra, Neha, primary, Tondini, Carlo, primary, Mirallas, Oriol, primary, Tovazzi, Valeria, primary, Betti, Marta, primary, Provenzano, Salvatore, primary, Fotia, Vittoria, primary, Cruz, Claudia Andrea, primary, Dalla Pria, Alessia, primary, D'Avanzo, Francesca, primary, Evans, Joanne S., primary, Saoudi-Gonzalez, Nadia, primary, Felip, Eudald, primary, Galazi, Myria, primary, Garcia-Fructuoso, Isabel, primary, Lee, Alvin J.X., primary, Newsom-Davis, Thomas, primary, Patriarca, Andrea, primary, García-Illescas, David, primary, Reyes, Roxana, primary, Dileo, Palma, primary, Sharkey, Rachel, primary, Wong, Yien Ning Sophia, primary, Ferrante, Daniela, primary, Marco-Hernández, Javier, primary, Sureda, Anna, primary, Maluquer, Clara, primary, Ruiz-Camps, Isabel, primary, Gaidano, Gianluca, primary, Rimassa, Lorenza, primary, Chiudinelli, Lorenzo, primary, Izuzquiza, Macarena, primary, Cabirta, Alba, primary, Franchi, Michela, primary, Santoro, Armando, primary, Prat, Aleix, primary, Tabernero, Josep, primary, Gennari, Alessandra, primary, Avanzi, Gian Carlo, primary, Bellan, Mattia, primary, Castello, Luigi Mario, primary, Martinez, Maria, primary, Mollà, Meritxell, primary, Pirisi, Mario, primary, Scotti, Lorenza, primary, and Swallow, Judith, primary

Published
2023
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10. SARS-CoV-2 omicron (B.1.1.529)-related COVID-19 sequelae in vaccinated and unvaccinated patients with cancer: results from the OnCovid registry

Author

Cortellini, Alessio, primary, Tabernero, Josep, additional, Mukherjee, Uma, additional, Salazar, Ramon, additional, Sureda, Anna, additional, Maluquer, Clara, additional, Ferrante, Daniela, additional, Bower, Mark, additional, Sharkey, Rachel, additional, Mirallas, Oriol, additional, Plaja, Andrea, additional, Cucurull, Marc, additional, Mesia, Ricard, additional, Dalla Pria, Alessia, additional, Newsom-Davis, Thomas, additional, Van Hemelrijck, Mieke, additional, Sita-Lumsden, Ailsa, additional, Apthorp, Eleanor, additional, Vincenzi, Bruno, additional, Di Fazio, Giuseppina Rita, additional, Tonini, Giuseppe, additional, Pantano, Francesco, additional, Bertuzzi, Alexia, additional, Rossi, Sabrina, additional, Brunet, Joan, additional, Lambertini, Matteo, additional, Pedrazzoli, Paolo, additional, Biello, Federica, additional, D'Avanzo, Francesca, additional, Lee, Alvin J X, additional, Shawe-Taylor, Marianne, additional, Rogers, Lucy, additional, Murphy, Cian, additional, Cooper, Lee, additional, Andaleeb, Ramis, additional, Khalique, Saira, additional, Bawany, Samira, additional, Ahmed, Sarah, additional, Carmona-García, M Carmen, additional, Fort-Culillas, Roser, additional, Liñan, Raquel, additional, Zoratto, Federica, additional, Rizzo, Gianpiero, additional, Perachino, Marta, additional, Doonga, Kris, additional, Gaidano, Gianluca, additional, Bruna, Riccardo, additional, Patriarca, Andrea, additional, Martinez-Vila, Clara, additional, Pérez Criado, Ignacio, additional, Giusti, Raffaele, additional, Mazzoni, Francesca, additional, Antonuzzo, Lorenzo, additional, Santoro, Armando, additional, Parisi, Alessandro, additional, Queirolo, Paola, additional, Aujayeb, Avinash, additional, Rimassa, Lorenza, additional, Diamantis, Nikolaos, additional, Bertulli, Rossella, additional, Fulgenzi, Claudia A M, additional, D'Alessio, Antonio, additional, Ruiz-Camps, Isabel, additional, Saoudi-Gonzalez, Nadia, additional, Garcia Illescas, David, additional, Medina, Irene, additional, Fox, Laura, additional, Gennari, Alessandra, additional, Aguilar-Company, Juan, additional, Pinato, David J, additional, Evans, Joanne S, additional, Swallow, Judith, additional, Hanbury, Georgina, additional, Chung, Chris, additional, Patel, Meera, additional, Dettorre, Gino, additional, Belessiotis, Katherine, additional, Saorise, Dolly, additional, Jones, Eleanor, additional, Moss, Charlotte, additional, Russell, Beth, additional, Townsend, Sarah, additional, Jackson, Amanda, additional, Loizidou, Angela, additional, Piccart, Martine, additional, Pommeret, Fanny, additional, Colomba-Blameble, Emeline, additional, Prat, Aleix, additional, Cruz, Claudia A, additional, Reyes, Roxana, additional, Segui, Elia, additional, Marco-Hernández, Javier, additional, Viladot, Margarita, additional, Harbeck, Nadia, additional, Wuerstlein, Rachel, additional, Henze, Franziska, additional, Mahner, Sven, additional, Felip, Eudald, additional, Scotti, Lorenza, additional, Marrari, Andrea, additional, Grosso, Federica, additional, Fusco, Vittorio, additional, Delfanti, Sara, additional, Rossi, Maura, additional, Zambelli, Alberto, additional, Tondini, Carlo, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Libertini, Michela, additional, Provenzano, Salvatore, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Baggi, Alice, additional, Tovazzi, Valeria, additional, Ficorella, Corrado, additional, Porzio, Giampiero, additional, Saponara, Maristella, additional, Filetti, Marco, additional, Tucci, Marco, additional, Berardi, Rossana, additional, Cantini, Luca, additional, Paoloni, Francesco, additional, Guida, Annalisa, additional, Bracarda, Sergio, additional, Iglesias, Maria, additional, Sanchez de Torre, Ana, additional, and Tagliamento, Marco, additional

Published
2023
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12. Vaccination against SARS-CoV-2 protects from morbidity, mortality and sequelae from COVID19 in patients with cancer

Author

Pinato, David J., primary, Ferrante, Daniela, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Salazar, Ramon, additional, Mirallas, Oriol, additional, Sureda, Anna, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Lambertini, Matteo, additional, Maluquer, Clara, additional, Pedrazzoli, Paolo, additional, Biello, Federica, additional, Lee, Alvin J.X., additional, Sng, Christopher C.T., additional, Liñan, Raquel, additional, Rossi, Sabrina, additional, Carmona-García, M.Carmen, additional, Sharkey, Rachel, additional, Eremiev, Simeon, additional, Rizzo, Gianpiero, additional, Bain, Hamish DC., additional, Yu, Tamara, additional, Cruz, Claudia A., additional, Perachino, Marta, additional, Saoudi-Gonzalez, Nadia, additional, Fort-Culillas, Roser, additional, Doonga, Kris, additional, Fox, Laura, additional, Roldán, Elisa, additional, Zoratto, Federica, additional, Gaidano, Gianluca, additional, Ruiz-Camps, Isabel, additional, Bruna, Riccardo, additional, Patriarca, Andrea, additional, Shawe-Taylor, Marianne, additional, Fusco, Vittorio, additional, Martinez-Vila, Clara, additional, Berardi, Rossana, additional, Filetti, Marco, additional, Mazzoni, Francesca, additional, Santoro, Armando, additional, Delfanti, Sara, additional, Parisi, Alessandro, additional, Queirolo, Paola, additional, Aujayeb, Avinash, additional, Rimassa, Lorenza, additional, Prat, Aleix, additional, Tabernero, Josep, additional, Gennari, Alessandra, additional, Cortellini, Alessio, additional, Pinato, David J., additional, Evans, Joanne S., additional, Swallow, Judith, additional, Hanbury, Georgina, additional, Chung, Chris, additional, Patel, Meera, additional, Dettorre, Gino, additional, Ottaviani, Diego, additional, Chowdhury, Amani, additional, Lee, Alvin JX., additional, Sng, Christopher CT., additional, Sinclair, Alasdair, additional, Cooper, Lee, additional, Rogers, Lucy, additional, Belessiotis, Katherine, additional, Murphy, Cian, additional, Bawany, Samira, additional, Khalique, Saira, additional, Andaleeb, Ramis, additional, Dalla Pria, Alessia, additional, Newsom-Davis, Thomas, additional, Dolly, Saorise, additional, Sita-Lumsde, Ailsa, additional, Apthorp, Eleanor, additional, Jones, Eleanor, additional, Van Hemelrijck, Mieke, additional, Moss, Charlotte, additional, Russell, Beth, additional, Diamantis, Nikolaos, additional, Mukherjee, Uma, additional, Townsend, Sarah, additional, Jackson, Amanda, additional, Loizidou, Angela, additional, Piccart, Martine, additional, Reyes, Roxana, additional, Segui, Elia, additional, Marco-Hernández, Javier, additional, Viladot, Margarita, additional, Garcia Illescas, David, additional, Saoudi, Nadia, additional, Carmona Garcia, MCarmen, additional, Fort-Culillas, Robert, additional, Harbeck, Nadia, additional, Wuerstlein, Rachel, additional, Henze, Franziska, additional, Mahner, Sven, additional, Mesia, Ricard, additional, Felip, Eudald, additional, Plaja, Andrea, additional, Cucurull, Marc, additional, D’Avanzo, Francesca, additional, Scotti, Lorenza, additional, Krengly, Marco, additional, Marrari, Andrea, additional, Grosso, Federica, additional, Maconi, Antonio, additional, Betti, Marta, additional, Vincenzi, Bruno, additional, Tonini, Giuseppe, additional, Zambelli, Alberto, additional, Tondini, Carlo, additional, Fotia, Vittoria, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Libertini, Michela, additional, Bertulli, Rossella, additional, Provenzano, Salvatore, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Baggi, Alice, additional, Tovazzi, Valeria, additional, Ficorella, Corrado, additional, Porzio, Giampiero, additional, Saponara, Maristella, additional, Giusti, Raffaele, additional, Tucci, Marco, additional, Cantini, Luca, additional, Paoloni, Francesco, additional, Guida, Annalisa, additional, Bracarda, Sergio, additional, Iglesias, Maria, additional, Sanchez de Torre, Ana, additional, Pommeret, Fanny, additional, and Colomba, Emeline, additional

Published
2022
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13. Outcomes of the SARS-CoV-2 omicron (B.1.1.529) variant outbreak among vaccinated and unvaccinated patients with cancer in Europe: results from the retrospective, multicentre, OnCovid registry study

Author

Pinato, David J, primary, Aguilar-Company, Juan, additional, Ferrante, Daniela, additional, Hanbury, Georgina, additional, Bower, Mark, additional, Salazar, Ramon, additional, Mirallas, Oriol, additional, Sureda, Anna, additional, Plaja, Andrea, additional, Cucurull, Marc, additional, Mesia, Ricard, additional, Townsend, Sarah, additional, Jackson, Amanda, additional, Dalla Pria, Alessia, additional, Newsom-Davis, Thomas, additional, Handford, Jasmine, additional, Sita-Lumsden, Ailsa, additional, Apthorp, Eleanor, additional, Vincenzi, Bruno, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Lambertini, Matteo, additional, Maluquer, Clara, additional, Pedrazzoli, Paolo, additional, Biello, Federica, additional, Sinclair, Alasdair, additional, Bawany, Samira, additional, Khalique, Saira, additional, Rossi, Sabrina, additional, Rogers, Lucy, additional, Murphy, Cian, additional, Belessiotis, Katherine, additional, Carmona-García, M Carmen, additional, Sharkey, Rachel, additional, García-Illescas, David, additional, Rizzo, Gianpiero, additional, Perachino, Marta, additional, Saoudi-Gonzalez, Nadia, additional, Doonga, Kris, additional, Fox, Laura, additional, Roldán, Elisa, additional, Gaidano, Gianluca, additional, Ruiz-Camps, Isabel, additional, Bruna, Riccardo, additional, Patriarca, Andrea, additional, Martinez-Vila, Clara, additional, Cantini, Luca, additional, Zambelli, Alberto, additional, Giusti, Raffaele, additional, Mazzoni, Francesca, additional, Caliman, Enrico, additional, Santoro, Armando, additional, Grosso, Federica, additional, Parisi, Alessandro, additional, Queirolo, Paola, additional, Aujayeb, Avinash, additional, Rimassa, Lorenza, additional, Prat, Aleix, additional, Tucci, Marco, additional, Libertini, Michela, additional, Grisanti, Salvatore, additional, Mukherjee, Uma, additional, Diamantis, Nikolaos, additional, Fusco, Vittorio, additional, Generali, Daniele, additional, Provenzano, Salvatore, additional, Gennari, Alessandra, additional, Tabernero, Josep, additional, Cortellini, Alessio, additional, Evans, Joanne S, additional, Swallow, Judith, additional, Chung, Chris, additional, Patel, Meera, additional, Dettorre, Gino, additional, Ottaviani, Diego, additional, Chowdhury, Amani, additional, Merry, Eve, additional, Chopra, Neha, additional, Lee, Alvin JX, additional, Sng, Christopher CT, additional, Yu, Tamara, additional, Shawe-Taylor, Marianne, additional, Bain, Hamish DC, additional, Wong, Yien Ning Sophia, additional, Galazi, Myria, additional, Benafif, Sarah, additional, Dileo, Palma, additional, Earnshaw, Irina, additional, Patel, Grisma, additional, Wu, Anjui, additional, Soosaipillai, Gehan, additional, Cooper, Lee, additional, Andaleeb, Ramis, additional, Dolly, Saoirse, additional, Srikandarajah, Krishnie, additional, Jones, Eleanor, additional, Van Hemelrijck, Mieke, additional, Moss, Charlotte, additional, Russell, Beth, additional, Chester, John, additional, Loizidou, Angela, additional, Piccart, Martine, additional, Cruz, Claudia A, additional, Reyes, Roxana, additional, Segui, Elia, additional, Marco-Hernández, Javier, additional, Viladot, Margarita, additional, Eremiev, Simeon, additional, Fort-Culillas, Roser, additional, Garcia, Isabel, additional, Liñan, Raquel, additional, Roqué Lloveras, Ariadna, additional, Harbeck, Nadia, additional, Wuerstlein, Rachel, additional, Henze, Franziska, additional, Mahner, Sven, additional, Felip, Eudald, additional, Pous, Anna, additional, D'Avanzo, Francesca, additional, Scotti, Lorenza, additional, Krengli, Marco, additional, Marrari, Andrea, additional, Delfanti, Sara, additional, Maconi, Antonio, additional, Betti, Marta, additional, Tonini, Giuseppe, additional, Di Fazio, Giuseppina Rita, additional, Tondini, Carlo, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Bertulli, Rossella, additional, Baggi, Alice, additional, Tovazzi, Valeria, additional, Ficorella, Corrado, additional, Porzio, Giampiero, additional, Saponara, Maristella, additional, Filetti, Marco, additional, Zoratto, Federica, additional, Paoloni, Francesco, additional, Berardi, Rossana, additional, Guida, Annalisa, additional, Bracarda, Sergio, additional, Iglesias, Maria, additional, Sanchez de Torre, Ana, additional, Tagliamento, Marco, additional, Colomba, Emeline, additional, and Pommeret, Fanny, additional

Published
2022
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14. Clinical and pathological prognostic factors in Merkel cell carcinoma.

Author

Tovazzi, Valeria, primary, Lorini, Luigi, additional, Battocchio, Simonetta, additional, Zannoni, Marina, additional, Paolino, Gaetano, additional, Cingarlini, Sara, additional, Zamparini, Manuel, additional, Tomasoni, Michele, additional, Ravanelli, Marco, additional, Oberti, Arianna, additional, Grammatica, Alberto, additional, Buglione, Michela, additional, Magrini, Stefano M., additional, Maroldi, Roberto, additional, Piazza, Cesare, additional, Facchetti, Fabio, additional, Scarpa, Aldo, additional, Berruti, Alfredo, additional, and Bossi, Paolo, additional

Published
2022
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15. Immunotherapy followed by cetuximab in locally advanced/metastatic (LA/M) cutaneous squamous cell carcinomas (cSCC): The I-TACKLE trial.

Author

Bossi, Paolo, primary, Alberti, Andrea, additional, Bergamini, Cristiana, additional, Resteghini, Carlo, additional, Locati, Laura Deborah, additional, Alfieri, Salvatore, additional, Cavalieri, Stefano, additional, Colombo, Elena, additional, Gurizzan, Cristina, additional, Lorini, Luigi, additional, Tovazzi, Valeria, additional, Zamparini, Manuel, additional, Ravanelli, Marco, additional, Ascierto, Paolo Antonio, additional, Rampinelli, Vittorio, additional, Grammatica, Alberto, additional, Patuzzo, Roberto, additional, Maurichi, Andrea, additional, and Licitra, Lisa F., additional

Published
2022
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16. Prevalence and impact of COVID-19 sequelae on treatment and survival of patients with cancer who recovered from SARS-CoV-2 infection: evidence from the OnCovid retrospective, multicentre registry study

Author

Pinato, David J, primary, Tabernero, Josep, additional, Bower, Mark, additional, Scotti, Lorenza, additional, Patel, Meera, additional, Colomba, Emeline, additional, Dolly, Saoirse, additional, Loizidou, Angela, additional, Chester, John, additional, Mukherjee, Uma, additional, Zambelli, Alberto, additional, Dalla Pria, Alessia, additional, Aguilar-Company, Juan, additional, Ottaviani, Diego, additional, Chowdhury, Amani, additional, Merry, Eve, additional, Salazar, Ramon, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Lambertini, Matteo, additional, Tagliamento, Marco, additional, Pous, Anna, additional, Sita-Lumsden, Ailsa, additional, Srikandarajah, Krishnie, additional, Colomba, Johann, additional, Pommeret, Fanny, additional, Seguí, Elia, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Pedrazzoli, Paolo, additional, Rizzo, Gianpiero, additional, Libertini, Michela, additional, Moss, Charlotte, additional, Evans, Joanne S, additional, Russell, Beth, additional, Harbeck, Nadia, additional, Vincenzi, Bruno, additional, Biello, Federica, additional, Bertulli, Rossella, additional, Liñan, Raquel, additional, Rossi, Sabrina, additional, Carmona-García, Maria Carmen, additional, Tondini, Carlo, additional, Fox, Laura, additional, Baggi, Alice, additional, Fotia, Vittoria, additional, Parisi, Alessandro, additional, Porzio, Giampero, additional, Saponara, Maristella, additional, Cruz, Claudia Andrea, additional, García-Illescas, David, additional, Felip, Eudald, additional, Roqué Lloveras, Ariadna, additional, Sharkey, Rachel, additional, Roldán, Elisa, additional, Reyes, Roxana, additional, Earnshaw, Irina, additional, Ferrante, Daniela, additional, Marco-Hernández, Javier, additional, Ruiz-Camps, Isabel, additional, Gaidano, Gianluca, additional, Patriarca, Andrea, additional, Bruna, Riccardo, additional, Sureda, Anna, additional, Martinez-Vila, Clara, additional, Sanchez de Torre, Ana, additional, Cantini, Luca, additional, Filetti, Marco, additional, Rimassa, Lorenza, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Krengli, Marco, additional, Santoro, Armando, additional, Prat, Aleix, additional, Van Hemelrijck, Mieke, additional, Diamantis, Nikolaos, additional, Newsom-Davis, Thomas, additional, Gennari, Alessandra, additional, Cortellini, Alessio, additional, Swallow, Judith, additional, Chung, Chris, additional, Dettorre, Gino, additional, Chopra, Neha, additional, Lee, Alvin JX, additional, Sng, Christopher CT, additional, Wong, Yien Ning Sophia, additional, Galazi, Myria, additional, Benafif, Sarah, additional, Dileo, Palma, additional, Patel, Grisma, additional, Wu, Anjui, additional, Sinclair, Alasdair, additional, Soosaipillai, Gehan, additional, Jones, Eleanor, additional, Jackson, Amanda, additional, Piccart, Martine, additional, Colomba-Blameble, Emeline, additional, Cruz, Claudia A, additional, Segui, Elia, additional, Garcia Illescas, David, additional, Mirallas, Oriol, additional, Carbó, Anna, additional, Garcia, Isabel, additional, Wuerstlein, Rachel, additional, Mesia, Ricard, additional, Maluquer, Clara, additional, D'Avanzo, Francesca, additional, Tonini, Giuseppe, additional, Provenzano, Salvatore, additional, Tovazzi, Valeria, additional, Ficorella, Corrado, additional, Queirolo, Paola, additional, Giusti, Raffaele, additional, Mazzoni, Francesca, additional, Zoratto, Federica, additional, Tucci, Marco, additional, Berardi, Rossana, additional, Guida, Annalisa, additional, Bracarda, Sergio, additional, and Iglesias, Maria, additional

Published
2021
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17. Accurate Triage of Oncological Patients for Safely Continuing Cancer Therapy During the SARS-CoV-2 Pandemic

Author

Gurizzan, Cristina, primary, Pedersini, Rebecca, additional, Fornaro, Carla, additional, Sardini, Chiara, additional, Zamparini, Manuel, additional, Monteverdi, Sara, additional, Tovazzi, Valeria, additional, Cosentini, Deborah, additional, Dalla Volta, Alberto, additional, Baggi, Alice, additional, Turla, Antonella, additional, Di Mauro, Pierluigi, additional, Lorini, Luigi, additional, Laganà, Marta, additional, Bianchi, Susanna, additional, Grisanti, Salvatore, additional, Consoli, Francesca, additional, Conti, Elisabetta, additional, Bossi, Paolo, additional, and Berruti, Alfredo, additional

Published
2021
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19. Determinants of enhanced vulnerability to COVID-19 in UK cancer patients: a European Study

Author

Pinato, David J., Scotti, Lorenza, Gennari, Alessandra, Colomba-Blameble, Emeline, Dolly, Saoirse, Loizidou, Angela, Chester, John, Mukherjee, Uma, Zambelli, Alberto, Aguilar-Company, Juan, Bower, Mark, Galazi, Myria, Salazar, Ramon, Bertuzzi, Alexia, Brunet, Joan, Mesia, Ricard, Sita-Lumsden, Ailsa, Colomba, Johann, Pommeret, Fanny, Seguí, Elia, Biello, Federica, Generali, Daniele, Grisanti, Salvatore, Rizzo, Gianpiero, Libertini, Michela, Moss, Charlotte, Evans, Joanne S., Russell, Beth, Wuerstlein, Rachel, Vincenzi, Bruno, Bertulli, Rossella, Ottaviani, Diego, Liñan, Raquel, Marrari, Andrea, Carmona-García, M. Carmen, Sng, Christopher CT., Tondini, Carlo, Mirallas, Oriol, Tovazzi, Valeria, Fotia, Vittoria, Cruz, Claudia Andrea, Saoudi-Gonzalez, Nadia, Felip, Eudald, Roqué Lloveras, Ariadna, Lee, Alvin J.X., Newsom-Davis, Thomas, Sharkey, Rachel, Chung, Chris, García-Illescas, David, Reyes, Roxana, Sophia Wong, Yien Ning, Ferrante, Daniela, Marco-Hernández, Javier, Ruiz-Camps, Isabel, Gaidano, Gianluca, Patriarca, Andrea, Sureda, Anna, Martinez-Vila, Clara, Sanchez de Torre, Ana, Rimassa, Lorenza, Chiudinelli, Lorenzo, Franchi, Michela, Krengli, Marco, Santoro, Armando, Prat, Aleix, Tabernero, Josep, Van Hemelrijck, Mieke, Diamantis, Nikolaos, and Cortellini, Alessio

Subjects
Europe, SARS-CoV-2, COVID-19, cancer, UK, Mortality, Original Research
Abstract

Background Despite high contagiousness and rapid spread, SARS-CoV-2 has led to heterogeneous outcomes across affected nations. Within Europe, the United Kingdom (UK) is the most severely affected country, with a death toll in excess of 100.000 as of January 2021. We aimed to compare the national impact of COVID-19 on the risk of death in UK cancer patients versus those in continental Europe (EU). Methods We performed a retrospective analysis of the OnCovid study database, a European registry of cancer patients consecutively diagnosed with COVID-19 in 27 centres from February 27 to September 10, 2020. We analysed case fatality rates and risk of death at 30 days and 6 months stratified by region of origin (UK versus EU). We compared patient characteristics at baseline, including oncological and COVID-19 specific therapy across UK and EU cohorts and evaluated the association of these factors with the risk adverse outcome in multivariable Cox regression models. Findings Compared to EU (n=924), UK patients (n=468) were characterised by higher case fatality rates (40.38% versus 26.5%, p

Published
2021

20. Abstract 701: The acute phase response identifies cancer patients with adverse outcomes from SARS-CoV-2 infection as quantified by the OnCovid Inflammatory Score

Author

Dettorre, Gino M., primary, Dolly, Saoirse, additional, Loizidou, Angela, additional, Chester, John, additional, Jackson, Amanda, additional, Mukherjee, Uma, additional, Zambelli, Alberto, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Sng, Christopher C., additional, Salazar, Ramon, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Mesia, Ricard, additional, Sita-Lumsden, Ailsa, additional, Seguí, Elia, additional, Biello, Federica, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Seeva, Pavetha, additional, Rizzo, Gianpiero, additional, Libertini, Michela, additional, Maconi, Antonio, additional, Moss, Charlotte, additional, Tabernero, Josep, additional, Russell, Beth, additional, Harbeck, Nadia, additional, Vincenzi, Bruno, additional, Bertulli, Rossella, additional, Ottaviani, Diego, additional, Liñan, Raquel, additional, Marrari, Andrea, additional, Carmona-García, M. Carmen, additional, Chopra, Neha, additional, Tondini, Carlo, additional, Mirallas, Oriol, additional, Tovazzi, Valeria, additional, Fotia, Vittoria, additional, Cruz, Claudia Andrea, additional, Saoudi-Gonzalez, Nadia, additional, Felip, Eudald, additional, Roqué, Ariadna, additional, Lee, Alvin J., additional, Newsom-Davis, Thomas, additional, Patriarca, Andrea, additional, Rimassa, Lorenza, additional, Santoro, Armando, additional, Gennari, Alessandra, additional, Diamantis, Nikolaos, additional, and Pinato, David J., additional

Published
2021
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21. Determinants of enhanced vulnerability to coronavirus disease 2019 in UK patients with cancer: a European study

Author

Pinato, David J., primary, Scotti, Lorenza, additional, Gennari, Alessandra, additional, Colomba-Blameble, Emeline, additional, Dolly, Saoirse, additional, Loizidou, Angela, additional, Chester, John, additional, Mukherjee, Uma, additional, Zambelli, Alberto, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Galazi, Myria, additional, Salazar, Ramon, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Mesia, Ricard, additional, Sita-Lumsden, Ailsa, additional, Colomba, Johann, additional, Pommeret, Fanny, additional, Seguí, Elia, additional, Biello, Federica, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Rizzo, Gianpiero, additional, Libertini, Michela, additional, Moss, Charlotte, additional, Evans, Joanne S., additional, Russell, Beth, additional, Wuerstlein, Rachel, additional, Vincenzi, Bruno, additional, Bertulli, Rossella, additional, Ottaviani, Diego, additional, Liñan, Raquel, additional, Marrari, Andrea, additional, Carmona-García, M.C., additional, Sng, Christopher. C.T., additional, Tondini, Carlo, additional, Mirallas, Oriol, additional, Tovazzi, Valeria, additional, Fotia, Vittoria, additional, Cruz, Claudia A., additional, Saoudi-Gonzalez, Nadia, additional, Felip, Eudald, additional, R. Lloveras, Ariadna, additional, Lee, Alvin. J.X., additional, Newsom-Davis, Thomas, additional, Sharkey, Rachel, additional, Chung, Chris, additional, García-Illescas, David, additional, Reyes, Roxana, additional, Sophia Wong, Yien N., additional, Ferrante, Daniela, additional, Marco-Hernández, Javier, additional, Ruiz-Camps, Isabel, additional, Gaidano, Gianluca, additional, Patriarca, Andrea, additional, Sureda, Anna, additional, Martinez-Vila, Clara, additional, Sanchez de Torre, Ana, additional, Rimassa, Lorenza, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Krengli, Marco, additional, Santoro, Armando, additional, Prat, Aleix, additional, Tabernero, Josep, additional, V. Hemelrijck, Mieke, additional, Diamantis, Nikolaos, additional, and Cortellini, Alessio, additional

Published
2021
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22. Systemic pro-inflammatory response identifies patients with cancer with adverse outcomes from SARS-CoV-2 infection: the OnCovid Inflammatory Score

Author

Dettorre, Gino M., Dolly, Saoirse, Loizidou, Angela, Chester, John, Jackson, Amanda, Mukherjee, Uma, Zambelli, Alberto, Aguilar Company, Juan, Bower, Mark, Sng, Christopher C. T., Salazar Soler, Ramón, Bertuzzi, Alexia, Brunet, Joan, Mesia, Ricard, Sita-Lumsden, Ailsa, Seguí, Elia, Biello, Federica, Generali, Daniele, Grisanti, Salvatore, Seeva, Pavetha, Rizzo, Gianpiero, Libertini, Michela, Maconi, Antonio, Moss, Charlotte, Russell, Beth, Harbeck, Nadia, Vincenzi, Bruno, Bertulli, Rossella, Ottaviani, Diego, Liñan, Raquel, Marrari, Andrea, Carmona García, M. Carmen, Chopra, Neha, Tondini, Carlo Alberto, Mirallas, Oriol, Tovazzi, Valeria, Fotia, Vittoria, Cruz, Claudia Andrea, Saoudi González, Nadia, Felip, Eudald, Roqué, Ariadna, Lee, Alvin J. X., Newsom-Davis, Tom, García Illescas, David, Reyes, Roxana, Wong, Yien Ning Sophia, Ferrante, Daniela, Scotti, Lorenza, Marco Hernández, Javier, Ruiz Camps, Isabel, Patriarca, Andrea, Rimassa, Lorenza, Chiudinelli, Lorenzo, Franchi, Michela, Santoro, Armando, Prat Aparicio, Aleix, Gennari, Alessandra, Van Hemelrijck, Mieke, Tabernero Caturla, Josep, Diamantis, Nikolaos, Pinato, David J., OnCovid study group, Dettorre, G. M., Dolly, S., Loizidou, A., Chester, J., Jackson, A., Mukherjee, U., Zambelli, A., Aguilar-Company, J., Bower, M., Sng, C. C. T., Salazar, R., Bertuzzi, A., Brunet, J., Mesia, R., Sita-Lumsden, A., Segui, E., Biello, F., Generali, D., Grisanti, S., Seeva, P., Rizzo, G., Libertini, M., Maconi, A., Moss, C., Russell, B., Harbeck, N., Vincenzi, B., Bertulli, R., Ottaviani, D., Linan, R., Marrari, A., Carmen Carmona-Garcia, M., Chopra, N., Tondini, C. A., Mirallas, O., Tovazzi, V., Fotia, V., Cruz, C. A., Saoudi-Gonzalez, N., Felip, E., Roque, A., Lee, A. J. X., Newsom-Davis, T., Garcia-Illescas, D., Reyes, R., Wong, Y. N. S., Ferrante, D., Scotti, L., Marco-Hernandez, J., Ruiz-Camps, I., Patriarca, A., Rimassa, L., Chiudinelli, L., Franchi, M., Santoro, A., Prat, A., Gennari, A., Van Hemelrijck, M., Tabernero, J., Diamantis, N., Pinato, D. J., Wellcome Trust, Institut Català de la Salut, [Dettorre GM] Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London, UK. [Dolly S] Medical Oncology, Guy’s and St Thomas’ NHS Foundation Trust (GSTT), London, UK. [Loizidou A] Department of Infectious Diseases, Internal Medicine, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium. [Chester J] Medical Oncology, School of Medicine, Cardiff University, Cardiff, UK. Medical Oncology, Velindre Cancer Centre, Cardiff, UK. [Jackson A] Clinical Trials, Velindre Cancer Centre, Cardiff, UK. [Mukherjee U] Medical Oncology, Barts Health NHS Trust, London, UK. [Aguilar-Company J] Servei d’Oncologia Mèdica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Servei de Malalties Infeccioses, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Mirallas O, Saoudi-Gonzalez N, García-Illescas D] Servei d’Oncologia Mèdica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Ruiz-Camps I] Servei de Malalties Infeccioses, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Tabernero J] Servei d’Oncologia Mèdica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. IOB-Quiron, UVic-UCC, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Male, 0301 basic medicine, Oncology, Cancer Research, Comorbidity, Systemic inflammation, Otros calificadores::Otros calificadores::/complicaciones [Otros calificadores], COVID-19 Testing, 0302 clinical medicine, Neoplasms, Immunotherapy Biomarkers, virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], 80 and over, Immunology and Allergy, Medicine, Hypoalbuminemia, Young adult, Càncer, Multivariate Analysi, RC254-282, COVID-19 (Malaltia) - Complicacions, Cancer, Aged, 80 and over, OnCovid study group, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], Middle Aged, Prognosis, Inflamació, Systemic Inflammatory Response Syndrome, 030220 oncology & carcinogenesis, Cohort, Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation::Systemic Inflammatory Response Syndrome [DISEASES], Molecular Medicine, Female, medicine.symptom, Life Sciences & Biomedicine, Human, Adult, medicine.medical_specialty, Prognosi, Càncer - Epidemiologia, Immunology, neoplasias [ENFERMEDADES], inflammation mediator, Young Adult, 03 medical and health sciences, Internal medicine, Humans, afecciones patológicas, signos y síntomas::procesos patológicos::inflamación::síndrome de respuesta inflamatoria sistémica [ENFERMEDADES], Aged, Pharmacology, Science & Technology, business.industry, SARS-CoV-2, COVID-19, medicine.disease, inflammation, inflammation mediators, Blood Cell Count, Multivariate Analysis, Neoplasms [DISEASES], Systemic inflammatory response syndrome, 030104 developmental biology, Neoplasm, Lymphocytopenia, business, Other subheadings::Other subheadings::/complications [Other subheadings]
Abstract

Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Inflamació; Mediadors d'inflamació Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Inflamación; Mediadores de la inflamación Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Inflammation; Inflammation mediators Background Patients with cancer are particularly susceptible to SARS-CoV-2 infection. The systemic inflammatory response is a pathogenic mechanism shared by cancer progression and COVID-19. We investigated systemic inflammation as a driver of severity and mortality from COVID-19, evaluating the prognostic role of commonly used inflammatory indices in SARS-CoV-2-infected patients with cancer accrued to the OnCovid study. Methods In a multicenter cohort of SARS-CoV-2-infected patients with cancer in Europe, we evaluated dynamic changes in neutrophil:lymphocyte ratio (NLR); platelet:lymphocyte ratio (PLR); Prognostic Nutritional Index (PNI), renamed the OnCovid Inflammatory Score (OIS); modified Glasgow Prognostic Score (mGPS); and Prognostic Index (PI) in relation to oncological and COVID-19 infection features, testing their prognostic potential in independent training (n=529) and validation (n=542) sets. Results We evaluated 1071 eligible patients, of which 625 (58.3%) were men, and 420 were patients with malignancy in advanced stage (39.2%), most commonly genitourinary (n=216, 20.2%). 844 (78.8%) had ≥1 comorbidity and 754 (70.4%) had ≥1 COVID-19 complication. NLR, OIS, and mGPS worsened at COVID-19 diagnosis compared with pre-COVID-19 measurement (p

Published
2021

23. Abstract S01-03: The acute phase response identifies cancer patients with adverse outcomes from SARS-CoV-2 infection as quantified by the OnCovid Inflammatory Score

Author

Dettorre, Gino M., primary, Dolly, Saoirse, additional, Loizidou, Angela, additional, Chester, John, additional, Jackson, Amanda, additional, Mukherjee, Uma, additional, Zambelli, Alberto, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Sng, Christopher C. T., additional, Salazar, Ramon, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Mesia, Ricard, additional, Sita-Lumsden, Ailsa, additional, Seguí, Elia, additional, Biello, Federica, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Seeva, Pavetha, additional, Rizzo, Gianpiero, additional, Libertini, Michela, additional, Maconi, Antonio, additional, Moss, Charlotte, additional, Russell, Beth, additional, Tabernero, Josep, additional, Harbeck, Nadia, additional, Vincenzi, Bruno, additional, Bertulli, Rossella, additional, Ottaviani, Diego, additional, Marrari, Andrea, additional, Carmona-García, M. Carmen, additional, Chopra, Neha, additional, Tondini, Carlo, additional, Mirallas, Oriol, additional, Tovazzi, Valeria, additional, Fotia, Vittoria, additional, Cruz, Claudia A., additional, Saoudi-Gonzalez, Nadia, additional, Felip, Eudald, additional, Scotti, Lorenza, additional, Lee, Alvin J. X., additional, Newsom-Davis, Thomas, additional, Patriarca, Andrea, additional, Rimassa, Lorenza, additional, Santoro, Armando, additional, Gennari, Alessandra, additional, Van Hemelrijck, Mieke, additional, Diamantis, Nikolaos, additional, and Pinato, David J., additional

Published
2021
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24. Systemic pro-inflammatory response identifies patients with cancer with adverse outcomes from SARS-CoV-2 infection: the OnCovid Inflammatory Score

Author

Dettorre, Gino M, primary, Dolly, Saoirse, additional, Loizidou, Angela, additional, Chester, John, additional, Jackson, Amanda, additional, Mukherjee, Uma, additional, Zambelli, Alberto, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Sng, Christopher C T, additional, Salazar, Ramon, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Mesia, Ricard, additional, Sita-Lumsden, Ailsa, additional, Seguí, Elia, additional, Biello, Federica, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Seeva, Pavetha, additional, Rizzo, Gianpiero, additional, Libertini, Michela, additional, Maconi, Antonio, additional, Moss, Charlotte, additional, Russell, Beth, additional, Harbeck, Nadia, additional, Vincenzi, Bruno, additional, Bertulli, Rossella, additional, Ottaviani, Diego, additional, Liñan, Raquel, additional, Marrari, Andrea, additional, Carmona-García, M Carmen, additional, Chopra, Neha, additional, Tondini, Carlo Alberto, additional, Mirallas, Oriol, additional, Tovazzi, Valeria, additional, Fotia, Vittoria, additional, Cruz, Claudia Andrea, additional, Saoudi-Gonzalez, Nadia, additional, Felip, Eudald, additional, Roqué, Ariadna, additional, Lee, Alvin J X, additional, Newsom-Davis, Tom, additional, García-Illescas, David, additional, Reyes, Roxana, additional, Wong, Yien Ning Sophia, additional, Ferrante, Daniela, additional, Scotti, Lorenza, additional, Marco-Hernández, Javier, additional, Ruiz-Camps, Isabel, additional, Patriarca, Andrea, additional, Rimassa, Lorenza, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Santoro, Armando, additional, Prat, Aleix, additional, Gennari, Alessandra, additional, Van Hemelrijck, Mieke, additional, Tabernero, Josep, additional, Diamantis, Nikolaos, additional, and Pinato, David J, additional

Published
2021
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25. Specialist palliative and end-of-life care for patients with cancer and SARS-CoV-2 infection: a European perspective

Author

Soosaipillai, Gehan, primary, Wu, Anjui, additional, Dettorre, Gino M, additional, Diamantis, Nikolaos, additional, Chester, John, additional, Moss, Charlotte, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Sng, Christopher CT, additional, Salazar, Ramon, additional, Brunet, Joan, additional, Jones, Eleanor, additional, Mesia, Ricard, additional, Jackson, Amanda, additional, Mukherjee, Uma, additional, Sita-Lumsden, Ailsa, additional, Seguí, Elia, additional, Ottaviani, Diego, additional, Carbó, Anna, additional, Benafif, Sarah, additional, Würstlein, Rachel, additional, Carmona, Carme, additional, Chopra, Neha, additional, Cruz, Claudia Andrea, additional, Swallow, Judith, additional, Saoudi, Nadia, additional, Felip, Eudald, additional, Galazi, Myria, additional, Garcia-Fructuoso, Isabel, additional, Lee, Alvin J. X., additional, Newsom-Davis, Thomas, additional, Wong, Yien Ning Sophia, additional, Sureda, Anna, additional, Maluquer, Clara, additional, Ruiz-Camps, Isabel, additional, Cabirta, Alba, additional, Prat, Aleix, additional, Loizidou, Angela, additional, Gennari, Alessandra, additional, Ferrante, Daniela, additional, Tabernero, Josep, additional, Russell, Beth, additional, Van Hemelrijck, Mieke, additional, Dolly, Saoirse, additional, Hulbert-Williams, Nicholas J, additional, Pinato, David J, additional, Mollà, Meritxell, additional, Reyes, Roxana, additional, Marco-Hernández, Javier, additional, Bruna, Riccardo, additional, Biello, Federica, additional, Patriarca, Andrea, additional, Zambelli, Alberto, additional, Tondini, Carlo, additional, Fotia, Vittoria, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Tovazzi, Valeria, additional, Bertuzzi, Alexia, additional, Marrari, Andrea, additional, Seeva, Pavetha, additional, Dileo, Palma, additional, Rizzo, Gianpiero, additional, Libertini, Michela, additional, Maconi, Antonio, additional, Betti, Marta, additional, Provenzano, Salvatore, additional, Harbeck, Nadia, additional, Vincenzi, Bruno, additional, Bertulli, Rossella, additional, Liñan, Raquel, additional, Roqué, Ariadna, additional, Mirallas, Oriol, additional, García-Illescas, David, additional, Scotti, Lorenza, additional, Dalla Pria, Alessia, additional, D’Avanzo, Francesca, additional, Martinez, Maria, additional, Evans, Joanne S, additional, Sharkey, Rachel, additional, Rimassa, Lorenza, additional, Santoro, Armando, additional, Gaidano, Gianluca, additional, and Izuzquiza, Macarena, additional

Published
2021
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26. Clinical Portrait of the SARS-CoV-2 Epidemic in European Patients with Cancer

Author

Pinato, David J., primary, Zambelli, Alberto, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Sng, Christopher C.T., additional, Salazar, Ramon, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Mesia, Ricard, additional, Seguí, Elia, additional, Biello, Federica, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Rizzo, Gianpiero, additional, Libertini, Michela, additional, Maconi, Antonio, additional, Harbeck, Nadia, additional, Vincenzi, Bruno, additional, Bertulli, Rossella, additional, Ottaviani, Diego, additional, Carbó, Anna, additional, Bruna, Riccardo, additional, Benafif, Sarah, additional, Marrari, Andrea, additional, Wuerstlein, Rachel, additional, Carmona-Garcia, M. Carmen, additional, Chopra, Neha, additional, Tondini, Carlo, additional, Mirallas, Oriol, additional, Tovazzi, Valeria, additional, Betti, Marta, additional, Provenzano, Salvatore, additional, Fotia, Vittoria, additional, Cruz, Claudia Andrea, additional, Dalla Pria, Alessia, additional, D'Avanzo, Francesca, additional, Evans, Joanne S., additional, Saoudi-Gonzalez, Nadia, additional, Felip, Eudald, additional, Galazi, Myria, additional, Garcia-Fructuoso, Isabel, additional, Lee, Alvin J.X., additional, Newsom-Davis, Thomas, additional, Patriarca, Andrea, additional, García-Illescas, David, additional, Reyes, Roxana, additional, Dileo, Palma, additional, Sharkey, Rachel, additional, Wong, Yien Ning Sophia, additional, Ferrante, Daniela, additional, Marco-Hernández, Javier, additional, Sureda, Anna, additional, Maluquer, Clara, additional, Ruiz-Camps, Isabel, additional, Gaidano, Gianluca, additional, Rimassa, Lorenza, additional, Chiudinelli, Lorenzo, additional, Izuzquiza, Macarena, additional, Cabirta, Alba, additional, Franchi, Michela, additional, Santoro, Armando, additional, Prat, Aleix, additional, Tabernero, Josep, additional, Gennari, Alessandra, additional, Avanzi, Gian Carlo, additional, Bellan, Mattia, additional, Castello, Luigi Mario, additional, Martinez, Maria, additional, Mollà, Meritxell, additional, Pirisi, Mario, additional, Scotti, Lorenza, additional, and Swallow, Judith, additional

Published
2020
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27. The Spread of SARS-CoV-2 Infection Among the Medical Oncology Staff of ASST Spedali Civili of Brescia: Efficacy of Preventive Measures

Author

Dalla Volta, Alberto, primary, Valcamonico, Francesca, additional, Pedersini, Rebecca, additional, Fornaro, Carla, additional, Tovazzi, Valeria, additional, Monteverdi, Sara, additional, Baggi, Alice, additional, Consoli, Francesca, additional, Ferrari, Vittorio Domenico, additional, Grisanti, Salvatore, additional, Conti, Elisabetta, additional, Amoroso, Vito, additional, Bossi, Paolo, additional, and Berruti, Alfredo, additional

Published
2020
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28. A Rare Complex BRAF Mutation Involving Codon V600 and K601 in Primary Cutaneous Melanoma: Case Report

Author

Consoli, Francesca, primary, Barbieri, Gianluca, additional, Picciolini, Matteo, additional, Medicina, Daniela, additional, Bugatti, Mattia, additional, Tovazzi, Valeria, additional, Liserre, Barbara, additional, Zambelli, Claudia, additional, Zorzi, Fausto, additional, Berruti, Alfredo, additional, Giurisato, Emanuele, additional, and Vermi, William, additional

Published
2020
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31. Eight‐week interval in flushing and locking port‐a‐cath in cancer patients: A single‐institution experience and systematic review

Author

Fornaro, Carla, primary, Piubeni, Maria, additional, Tovazzi, Valeria, additional, Cosentini, Deborah, additional, Gelmi, Maria, additional, Rota, Gabriella, additional, Berta, Barbara, additional, Barucco, Wilma, additional, Lombardi, Eleonora, additional, Moles, Luisa, additional, Faustini, Tiziana, additional, Fettolini, Tiziana, additional, Motta, Paolo, additional, Ferrari, Vittorio D., additional, Berruti, Alfredo, additional, and Conti, Elisabetta, additional

Published
2018
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32. Eight‐week interval in flushing and locking port‐a‐cath in cancer patients: A single‐institution experience and systematic review.

Author

Fornaro, Carla, Piubeni, Maria, Tovazzi, Valeria, Cosentini, Deborah, Gelmi, Maria, Rota, Gabriella, Berta, Barbara, Barucco, Wilma, Lombardi, Eleonora, Moles, Luisa, Faustini, Tiziana, Fettolini, Tiziana, Motta, Paolo, Ferrari, Vittorio D., Berruti, Alfredo, and Conti, Elisabetta

Subjects
BLOOD vessels, CANCER patients, CATHETERIZATION complications, CHI-squared test, HEPARIN, IRRIGATION (Medicine), MEDICAL equipment, MEDLINE, ONLINE information services, PHYSIOLOGIC salines, TIME, SYSTEMATIC reviews, RETROSPECTIVE studies, VASCULAR catheters, DATA analysis software, DESCRIPTIVE statistics
Abstract

Port‐a‐cath (PAC) system is one of the most frequently employed venous accesses for administration of chemotherapy and supportive care. To prevent late complications, the latest guidelines recommend flushing/locking procedures every four weeks. In this retrospective study, we evaluate the frequencies of late complications with a eight‐week flushing/locking procedure compared to the standard one. This study retrospectively compares the frequency of complications occurred using standard versus delayed flushing schedules. We performed a systematic review of the published studies about PAC complications associated with longer flushing intervals. Three hundred and ninety fully available patients were enrolled. One hundred and six patients had their PAC flushed/locked every month, 347 patients performed the flushing/locking procedures every eight weeks, 63 patients switched from the four to the eight‐week schedule. No difference was seen in the number of occlusions, infections and mechanical dysfunctions between the two patient groups. The systematic literature review confirmed, in a total of 1,347 patients, the absence of an increased proportion of complications with delayed schedules. PAC flushing and locking every eight weeks are feasible and safe. This delayed schedule may improve patients' quality of life and decrease both nursing workload and costs for the national health system. [ABSTRACT FROM AUTHOR]

Published
2019
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33. Immunotherapy followed by cetuximab in locally advanced/metastatic (LA/M) cutaneous squamous cell carcinomas (cSCC): The I-TACKLE trial

Author

Bossi, Paolo, Alberti, Andrea, Bergamini, Cristiana, Resteghini, Carlo, Laura Deborah Locati, Alfieri, Salvatore, Cavalieri, Stefano, Colombo, Elena, Gurizzan, Cristina, Lorini, Luigi, Tovazzi, Valeria, Zamparini, Manuel, Ravanelli, Marco, Ascierto, Paolo Antonio, Rampinelli, Vittorio, Grammatica, Alberto, Patuzzo, Roberto, Maurichi, Andrea, and Licitra, Lisa F.

Subjects
Cancer Research, Oncology
Abstract

9520 Background: In LA/M cSCC patients (pts), immunotherapy with pembrolizumab (P) and cemiplimab showed an overall response rate (ORR) of 34-49%, with durable antitumor activity. However, primary and acquired resistance represents a therapeutic challenge. In cSCC, monotherapy with cetuximab (C) showed promising signs of activity (ORR 28%), but with limited duration of response. This study aims at reverting P resistance by adding C, leveraging on its mechanism of action in reducing immune escape process. Methods: I-TACKLE is an open-label, nonrandomized, phase II trial in pts with LA/M cSCC conducted in 3 Italian centers. Eligible pts had LA/M cSCC not manageable with surgery or radiation and with ECOG PS= 0 or 1. They received intravenous P 200 mg every 3 weeks. In case of partial (PR) or complete response (CR), pts continued to receive P alone. In case of stable disease (SD) or progression (PD), pts received C (400 mg/sm loading dose, then weekly 250 mg/sm) in addition to P until progression. The primary endpoint was cumulative ORR by single agent or by combination strategy; safety, PFS (since start of P and P+C), OS and duration of response (DOR) were secondary endpoints. Results: Between May 2019 and April 2021, 43 pts were enrolled and treated with P. Table 1 depicts population baseline features. The median follow up was 24 (range 7-30) months. Twenty-three pts underwent the combination treatment (17/23 due to PD and 6/23 due to SD); 21 of them due to primary resistance and 2 because of acquired resistance. Median treatment exposure was 3 and 4 months to P and combination therapy, respectively. Cumulative ORR was 63% [95% confidence interval 48-77], including 19/43 (44%) pts with response to P and 8/21 (38%) with response to combination strategy after primary resistance to P. Both pts experiencing an acquired resistance to P obtained PR when C was introduced. Overall, 10/23 pts (44%) obtained a response to combination therapy. Median DOR and OS were not reached both with P alone and with P+ C. One-year PFS was 51% with P alone and 42% with P+C. Overall, grade 3-4 treatment-related adverse events occurred in 7/43 (16%) pts during treatment with P and 8/23 (35%) pts during P+C, mostly dermatitis 7/23 (30%). Three out of 43 (7%) pts discontinued treatment because of toxicity, one pancreatitis, one impaired renal function and one for worsening of clinical condition, all during treatment with P. Four patients died during treatment, due to PD. Conclusions: In LA/M cSCC, the addition of C to P reverts primary and acquired resistance, with manageable toxicities. The sequential approach deserves to be studied in future clinical trials. Clinical trial information: NCT03666325. [Table: see text]

34. The acute phase response identifies cancer patients with adverse outcomes from SARS-CoV-2 infection as quantified by the OnCovid Inflammatory Score

Author

Dettorre, Gino M., Dolly, Saoirse, Loizidou, Angela, Chester, John, Jackson, Amanda, Mukherjee, Uma, Zambelli, Alberto, Aguilar-Company, Juan, Bower, Mark, Sng, Christopher C. T., Salazar, Ramon, Bertuzzi, Alexia, Brunet, Joan, Mesia, Ricard, Sita-Lumsden, Ailsa, Segui, Elia, Biello, Federica, Generali, Daniele, Grisanti, Salvatore, Seeva, Pavetha, Rizzo, Gianpiero, Libertini, Michela, Maconi, Antonio, Moss, Charlotte, Russell, Beth, Tabernero, Josep, Harbeck, Nadia, Vincenzi, Bruno, Bertulli, Rossella, Ottaviani, Diego, Marrari, Andrea, Carmona-Garcia, M. Carmen, Chopra, Neha, Tondini, Carlo, Mirallas, Oriol, Tovazzi, Valeria, Fotia, Vittoria, Cruz, Claudia A., Saoudi-Gonzalez, Nadia, Felip, Eudald, Scotti, Lorenza, Alvin Lee, Newsom-Davis, Thomas, Patriarca, Andrea, Rimassa, Lorenza, Santoro, Armando, Gennari, Alessandra, Hemelrijck, Mieke, Diamantis, Nikolaos, and Pinato, David J.

35. Determinants of enhanced vulnerability to coronavirus disease 2019 in UK patients with cancer: a European study

Author

Elia Seguí, Nadia Saoudi-Gonzalez, Federica Biello, Rachel Wuerstlein, Andrea Marrari, Carlo Tondini, Ramon Salazar, Lorenza Rimassa, Claudia Andrea Cruz, Nikolaos Diamantis, David J. Pinato, Armando Santoro, Salvatore Grisanti, Clara Martinez-Vila, Charlotte Moss, Lorenzo Chiudinelli, Daniele Generali, M. C. Carmona-Garcia, Vittoria Fotia, Alexia Bertuzzi, Ailsa Sita-Lumsden, Angela Loizidou, Christopher C T Sng, Bruno Vincenzi, Alessandra Gennari, Aleix Prat, David García-Illescas, Chris Chung, Fanny Pommeret, Diego Ottaviani, Daniela Ferrante, Ariadna Roqué Lloveras, Joan Brunet, Johann Colomba, Joanne Evans, Uma Mukherjee, Alvin J.X. Lee, Juan Aguilar-Company, Andrea Patriarca, Myria Galazi, Gianluca Gaidano, Javier Marco-Hernández, Eudald Felip, Marco Krengli, Gianpiero Rizzo, Isabel Ruiz-Camps, Thomas Newsom-Davis, Mark Bower, John D. Chester, Saoirse Dolly, Yien N. Sophia Wong, Ricard Mesia, Michela Franchi, Michela Libertini, Alessio Cortellini, Roxana Reyes, Lorenza Scotti, Josep Tabernero, Rossella Bertulli, Oriol Mirallas, Valeria Tovazzi, Emeline Colomba-Blameble, Anna Sureda, Beth Russell, Raquel Liñan, Rachel Sharkey, Mieke Van Hemelrijck, Alberto Zambelli, Ana Sanchez de Torre, Pinato, David J., Scotti, Lorenza, Gennari, Alessandra, Colomba-Blameble, Emeline, Dolly, Saoirse, Loizidou, Angela, Chester, John, Mukherjee, Uma, Zambelli, Alberto, Aguilar-Company, Juan, Bower, Mark, Galazi, Myria, Salazar, Ramon, Bertuzzi, Alexia, Brunet, Joan, Mesia, Ricard, Sita-Lumsden, Ailsa, Colomba, Johann, Pommeret, Fanny, Seguí, Elia, Biello, Federica, Generali, Daniele, Grisanti, Salvatore, Rizzo, Gianpiero, Libertini, Michela, Moss, Charlotte, Evans, Joanne S., Russell, Beth, Wuerstlein, Rachel, Vincenzi, Bruno, Bertulli, Rossella, Ottaviani, Diego, Liñan, Raquel, Marrari, Andrea, Carmona-García, M. C., Sng, Christopher. C. T., Tondini, Carlo, Mirallas, Oriol, Tovazzi, Valeria, Fotia, Vittoria, Cruz, Claudia A., Saoudi-Gonzalez, Nadia, Felip, Eudald, R. Lloveras, Ariadna, Lee, Alvin. J. X., Newsom-Davis, Thoma, Sharkey, Rachel, Chung, Chri, García-Illescas, David, Reyes, Roxana, Sophia Wong, Yien N., Ferrante, Daniela, Marco-Hernández, Javier, Ruiz-Camps, Isabel, Gaidano, Gianluca, Patriarca, Andrea, Sureda, Anna, Martinez-Vila, Clara, Sanchez de Torre, Ana, Rimassa, Lorenza, Chiudinelli, Lorenzo, Franchi, Michela, Krengli, Marco, Santoro, Armando, Prat, Aleix, Tabernero, Josep, V. Hemelrijck, Mieke, Diamantis, Nikolao, and Cortellini, Alessio

Subjects
0301 basic medicine, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Epidemiology, Case fatality rate, medicine, COVID-19, Cancer, Europe, Mortality, SARS-CoV-2, UK, Mechanical ventilation, business.industry, Proportional hazards model, medicine.disease, Comorbidity, Confidence interval, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cohort, business
Abstract

Background: Despite high contagiousness and rapid spread, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to heterogeneous outcomes across affected nations. Within Europe (EU), the United Kingdom (UK) is the most severely affected country, with a death toll in excess of 100,000 as of January 2021. We aimed to compare the national impact of coronavirus disease 2019 (COVID-19) on the risk of death in UK patients with cancer versus those in continental EU. Methods: We performed a retrospective analysis of the OnCovid study database, a European registry of patients with cancer consecutively diagnosed with COVID-19 in 27 centres from 27th February to 10th September 2020. We analysed case fatality rates and risk of death at 30 days and 6 months stratified by region of origin (UK versus EU). We compared patient characteristics at baseline including oncological and COVID-19-specific therapy across UKand EU cohorts and evaluated the association of these factors with the risk of adverse out-comes in multivariable Cox regression models Findings: Compared with EU (n = 924), UK patients (n = 468) were characterised by higher case fatality rates (40.38% versus 26.5%, p < 0.0001) and higher risk of death at 30 days (haz-ard ratio [HR], 1.64 [95% confidence interval {CI}, 1.36-1.99]) and 6 months after COVID-19 diagnosis (47.64% versus 33.33%; p < 0.0001; HR, 1.59 [95% CI, 1.33-1.88]). UK patients were more often men, were of older age and have more comorbidities than EU counterparts (p < 0.01). Receipt of anticancer therapy was lower in UK than in EU patients (p < 0.001). Despite equal proportions of complicated COVID-19, rates of intensive care admission and use of mechanical ventilation, UK patients with cancer were less likely to receive anti-COVID-19 therapies including corticosteroids, antivirals and inter leukin-6 antagonists (p < 0.0001). Multivariable analyses adjusted for imbalanced prognostic factors confirmed the UK cohort to be characterised by worse risk of death at 30 days and 6 months, indepen-dent of the patient's age, gender, tumour stage and status; number of comorbidities; COVID-19 severity and receipt of anticancer and anti-COVID-19 therapy. Rates of permanent cessa-tion of anticancer therapy after COVID-19 were similar in the UK and EU cohorts. Interpretation: UK patients with cancer have been more severely impacted by the unfolding of the COVID-19 pandemic despite societal risk mitigation factors and rapid deferral of anti-cancer therapy. The increased frailty of UK patients with cancer highlights high-risk groups that should be prioritised for anti-SARS-CoV-2 vaccination. Continued evaluation of long-term outcomes is warranted. (C) 2021 Elsevier Ltd. All rights reserved.

Published
2021

36. Clinical portrait of the SARS-CoV-2 epidemic in European cancer patients.

Author

Pinato DJ, Zambelli A, Aguilar-Company J, Bower M, Sng C, Salazar R, Bertuzzi A, Brunet J, Mesia R, Segui E, Biello F, Generali D, Grisanti S, Rizzo G, Libertini M, Maconi A, Harbeck N, Vincenzi B, Bertulli R, Ottaviani D, Carbo A, Bruna R, Benafif S, Marrari A, Wuerstlein R, Carmona-Garcia MC, Chopra N, Tondini C, Mirallas O, Tovazzi V, Betti M, Provenzano S, Fotia V, Cruz CA, Dalla Pria A, D'Avanzo F, Evans JS, Saoudi-Gonzalez N, Felip E, Galazi M, Garcia-Fructuoso I, Lee AJX, Newsom-Davis T, Patriarca A, Garcia-Illescas D, Reyes R, Dileo P, Sharkey R, Wong YNS, Ferrante D, Marco-Hernandez J, Sureda A, Maluquer C, Ruiz-Camps I, Gaidano G, Rimassa L, Chiudinelli L, Izuzquiza M, Cabirta A, Franchi M, Santoro A, Prat A, Tabernero J, and Gennari A

Abstract

The SARS-Cov-2 pandemic significantly impacted on oncology practice across the globe. There is uncertainty as to the contribution of patients' demographics and oncological features on severity and mortality from Covid-19 and little guidance as to the role of anti-cancer and anti-Covid-19 therapy in this population. In a multi-center study of 890 cancer patients with confirmed Covid-19 we demonstrated a worsening gradient of mortality from breast cancer to haematological malignancies and showed that male gender, older age, and number of co-morbidities identifies a subset of patients with significantly worse mortality rates from Covid-19. Provision of chemotherapy, targeted therapy and immunotherapy did not worsen mortality. Exposure to antimalarials was associated with improved mortality rates independent of baseline prognostic factors. This study highlights the clinical utility of demographic factors for individualized risk-stratification of patients and support further research into emerging anti-Covid-19 therapeutics in SARS-Cov-2 infected cancer patients., (Copyright ©2020, American Association for Cancer Research.)

Published
2020
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