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Determinants of enhanced vulnerability to COVID-19 in UK cancer patients: a European Study
- Source :
- European Journal of Cancer
- Publication Year :
- 2021
- Publisher :
- Elsevier Ltd., 2021.
-
Abstract
- Background Despite high contagiousness and rapid spread, SARS-CoV-2 has led to heterogeneous outcomes across affected nations. Within Europe, the United Kingdom (UK) is the most severely affected country, with a death toll in excess of 100.000 as of January 2021. We aimed to compare the national impact of COVID-19 on the risk of death in UK cancer patients versus those in continental Europe (EU). Methods We performed a retrospective analysis of the OnCovid study database, a European registry of cancer patients consecutively diagnosed with COVID-19 in 27 centres from February 27 to September 10, 2020. We analysed case fatality rates and risk of death at 30 days and 6 months stratified by region of origin (UK versus EU). We compared patient characteristics at baseline, including oncological and COVID-19 specific therapy across UK and EU cohorts and evaluated the association of these factors with the risk adverse outcome in multivariable Cox regression models. Findings Compared to EU (n=924), UK patients (n=468) were characterised by higher case fatality rates (40.38% versus 26.5%, p
- Subjects :
- Europe
SARS-CoV-2
COVID-19
cancer
UK
Mortality
Original Research
Subjects
Details
- Language :
- English
- ISSN :
- 18790852 and 09598049
- Database :
- OpenAIRE
- Journal :
- European Journal of Cancer
- Accession number :
- edsair.pmc...........f87caf0bb9f6c2bda30069a18910ea9b