1. Specificity of Quantitative Functional Brain Mapping with Arterial Spin-Labeling for Preoperative Assessment.
- Author
-
Iannotti GR, Nadin I, Ivanova V, Tourdot Q, Lascano AM, Momjian S, Schaller KL, Lovblad KO, and Grouiller F
- Subjects
- Humans, Spin Labels, Magnetic Resonance Imaging methods, Arteries, Cerebrovascular Circulation physiology, Brain Mapping methods, Brain blood supply
- Abstract
Background and Purpose: Arterial spin-labeling is a noninvasive MR imaging technique allowing direct and quantitative measurement of brain perfusion. Arterial spin-labeling is well-established in clinics for investigating the overall cerebral perfusion, but it is still occasionally employed during tasks. The typical contrast for functional MR imaging is blood oxygen level-dependent (BOLD) imaging, whose specificity could be biased in neurologic patients due to altered neurovascular coupling. This work aimed to validate the use of functional ASL as a noninvasive tool for presurgical functional brain mapping. This is achieved by comparing the spatial accuracy of functional ASL with transcranial magnetic stimulation as the criterion standard., Materials and Methods: Twenty-eight healthy participants executed a motor task and received a somatosensory stimulation, while BOLD imaging and arterial spin-labeling were acquired simultaneously. Transcranial magnetic stimulation was subsequently used to define hand somatotopy., Results: Functional ASL was found more adjacent to transcranial magnetic stimulation than BOLD imaging, with a significant shift along the inferior-to-superior direction. With respect to BOLD imaging, functional ASL was localized significantly more laterally, anteriorly, and inferiorly during motor tasks and pneumatic stimulation., Conclusions: Our results confirm the specificity of functional ASL in targeting the regional neuronal excitability. Functional ASL could be considered as a valid supplementary technique to BOLD imaging for presurgical mapping when spatial accuracy is crucial for delineating eloquent cortex., (© 2023 by American Journal of Neuroradiology.)
- Published
- 2023
- Full Text
- View/download PDF