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Specificity of Quantitative Functional Brain Mapping with Arterial Spin-Labeling for Preoperative Assessment.
- Source :
-
AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2023 Nov; Vol. 44 (11), pp. 1302-1308. Date of Electronic Publication: 2023 Oct 19. - Publication Year :
- 2023
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Abstract
- Background and Purpose: Arterial spin-labeling is a noninvasive MR imaging technique allowing direct and quantitative measurement of brain perfusion. Arterial spin-labeling is well-established in clinics for investigating the overall cerebral perfusion, but it is still occasionally employed during tasks. The typical contrast for functional MR imaging is blood oxygen level-dependent (BOLD) imaging, whose specificity could be biased in neurologic patients due to altered neurovascular coupling. This work aimed to validate the use of functional ASL as a noninvasive tool for presurgical functional brain mapping. This is achieved by comparing the spatial accuracy of functional ASL with transcranial magnetic stimulation as the criterion standard.<br />Materials and Methods: Twenty-eight healthy participants executed a motor task and received a somatosensory stimulation, while BOLD imaging and arterial spin-labeling were acquired simultaneously. Transcranial magnetic stimulation was subsequently used to define hand somatotopy.<br />Results: Functional ASL was found more adjacent to transcranial magnetic stimulation than BOLD imaging, with a significant shift along the inferior-to-superior direction. With respect to BOLD imaging, functional ASL was localized significantly more laterally, anteriorly, and inferiorly during motor tasks and pneumatic stimulation.<br />Conclusions: Our results confirm the specificity of functional ASL in targeting the regional neuronal excitability. Functional ASL could be considered as a valid supplementary technique to BOLD imaging for presurgical mapping when spatial accuracy is crucial for delineating eloquent cortex.<br /> (© 2023 by American Journal of Neuroradiology.)
Details
- Language :
- English
- ISSN :
- 1936-959X
- Volume :
- 44
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- AJNR. American journal of neuroradiology
- Publication Type :
- Academic Journal
- Accession number :
- 37857448
- Full Text :
- https://doi.org/10.3174/ajnr.A8006