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In recurrent cancer of the large intestine, hepatectomy for localized liver metastasis and extensive total pelvic exenteration for pelvic local recurrence are often beneficial and prolongation of life can be achieved. Histological venous invasion of original tumor (v-factor) is an important parameter in the prediction of liver metastasis, and nuclear magnetic resonance (NMR) is useful for detecting liver metastases and determining the extent of local invasion. Early diagnosis and aggressive treatment of recurrent and metastatic cancer are as important as early and curative resection of initial malignant lesions. Oral administration of biological response modifier (BRM) and adjuvant adoptive immunotherapy after hepatectomy are considered to be promising approaches for the prevention of recurrence.

Mesenteric lymph flow changes induced by the administration of 2 exogenous synthetic gastrointestinal hormones, porcine motilin and bovine neurotensin, were investigated in the cat. Motilin infusion (5–10 µg/kg/h) augmented the intestinal mesenteric lymph flow considerably, and this effect was abolished by concurrent infusion of neurotensin (5 µg/kg/h). The observed lymph flow changes induced by the 2 hormones correlated well chronologically with motility of the proximal intestine in this in vivo feline model. Enhanced contraction of the ileum and colon induced by the administration of neurotensin in this species indicates that species differences exist in this neurotensin response in motility of the distal intestine.