Diagnosis and Treatment of Recurrent Colorectal Cancer

In recurrent cancer of the large intestine, hepatectomy for localized liver metastasis and extensive total pelvic exenteration for pelvic local recurrence are often beneficial and prolongation of life can be achieved. Histological venous invasion of original tumor (v-factor) is an important parameter in the prediction of liver metastasis, and nuclear magnetic resonance (NMR) is useful for detecting liver metastases and determining the extent of local invasion. Early diagnosis and aggressive treatment of recurrent and metastatic cancer are as important as early and curative resection of initial malignant lesions. Oral administration of biological response modifier (BRM) and adjuvant adoptive immunotherapy after hepatectomy are considered to be promising approaches for the prevention of recurrence.