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We report a case of pleomorphic adenoma with marked calcification.A 63-year-old woman had an elastic spherical hard nodule measuring about 20×20mm in diameter at the tail of right parotid gland. A computed tomographic examination showed marked calcification within the clearly demarcated tumor nodule. Histologically, the tumor was composed of pleomorphic adenoma with abundant hyalinized matrix components. Numerous calcium granules were found in the fibrous connective tissues surrounding the tumor and demarcating it from the non-neoplastic atrophic parotid gland. Calcification granules were also associated with the degenerative tumor cells and cell debris. The pathogenesis of calcium deposition in the tumor tissue is briefly discussed.

UFT内服治療を行い著効を得た口腟癌の2症例を経験したので報告した。症例1は71歳女性, 舌癌 (T2N0M0) の根治手術後4年7か月で口底部切除縁付近に再発を来し, 根治的な2次治療を拒否されたためUFT 600mg/dayの内服投与を行った。2週問目より腫瘍は縮小傾向を示し, 4週問目には臨床的に腫瘍は消失し, 病理組織学的にもCRと判定した。症例2は83歳男性, 下顎歯肉癌 (T1N0M0) で喘息による心不全を合併しているため, 患者のQOLを考えUFT 600mg/dayとubenimx (ベスタチン) 30mg/dayを併用した内服治療を行った。3か月目頃より腫瘍は縮小傾向を示し, 6か月目には臨床的に腫瘍は消失, 病理組織学的にもCRと判定した。2症例とも現在まで1年6か月および8か月以上, 再発傾向は認められず経過観察中である。

The analgesic effect of 156-S on postoperative pain after removal of impacted lower wisdom teeth was clinically elvaluated. After the appropriate dose of 156-S was preliminarily studied among 50 mg, 100 mg, 200 mg, 300 mg, and 400 mg groups, 300 mg of 156-S was compared with 500 mg of mefenamic acid by the double blind test.The result were as follows:1) Of the total 520 cases, 408 cases (78. 5%) needed analgesics after the extraction.2) The analgesic effect of 156-S increased dosedependently among 50 mg, 100 mg, and 200 mg groups in the first preliminary test.3) 200 mg, 300 mg, and 400 mg of 156-S were clinically effective and useful to control the postoperative pain in the second preliminary test.4) Although both 300 mg of 156-S and 500 mg of mefenamic acid showed the almost same analgesic effect clinically, postoperative pain was statistically better controlled by 156-S than by mefenamic acid at 30 and 60 minutes after administration of the analgesics.However, the analgesic effect of mefenamic acid is statistically superior to that of 156-S at 4 hours after the administration. These results suggest that 156-S has quick analgesic action and mefenamic acid has a long one.5) Side effects of 156-S slight gastrointestinal disorder, were found in only 6 of 322 cases (1.8%).6) Therefore, 156-S is good for controlling the postoperative pain after extraction of impacted lower wisdom teeth.