Clinical evaluation of analgesic effect of 156-S on postoperative pain after extraction of impacted lower wisdom teeth

The analgesic effect of 156-S on postoperative pain after removal of impacted lower wisdom teeth was clinically elvaluated. After the appropriate dose of 156-S was preliminarily studied among 50 mg, 100 mg, 200 mg, 300 mg, and 400 mg groups, 300 mg of 156-S was compared with 500 mg of mefenamic acid by the double blind test.The result were as follows:1) Of the total 520 cases, 408 cases (78. 5%) needed analgesics after the extraction.2) The analgesic effect of 156-S increased dosedependently among 50 mg, 100 mg, and 200 mg groups in the first preliminary test.3) 200 mg, 300 mg, and 400 mg of 156-S were clinically effective and useful to control the postoperative pain in the second preliminary test.4) Although both 300 mg of 156-S and 500 mg of mefenamic acid showed the almost same analgesic effect clinically, postoperative pain was statistically better controlled by 156-S than by mefenamic acid at 30 and 60 minutes after administration of the analgesics.However, the analgesic effect of mefenamic acid is statistically superior to that of 156-S at 4 hours after the administration. These results suggest that 156-S has quick analgesic action and mefenamic acid has a long one.5) Side effects of 156-S slight gastrointestinal disorder, were found in only 6 of 322 cases (1.8%).6) Therefore, 156-S is good for controlling the postoperative pain after extraction of impacted lower wisdom teeth.