52 results on '"Torres MG"'
Search Results
2. Inflammatory mediators and immune response in Mexican adolescents.
- Author
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Pardo Morales RV, Zúñiga Torres MG, Martínez Carrillo BE, Gómez Martínez S, Marcos A, and Valdés Ramos R
- Abstract
Introduction: Low-grade inflammation and increased immunity related to cardiovascular diseases have been described in children and adults, however, studies in Mexican adolescents are being done at present. Objective: To evaluate inflammatory proteins and indicators of immunity in adolescents by gender and body mass index. Material and methods: 115 Mexican adolescents, 15-18 years old (36 men), were divided into non-overweight, risk of overweight and overweight by CDC pediatric criteria by body mass index. Serum concentrations of ceruloplasmin, C3 and C4 were quantified by nephelometry; IL-6 and TNF-[alpha] from stimulated supernatant were analyzed with Human Th1-Th2 cytokine CBA II kit (BD Biosciences Pharmigen, San Diego, CA), and detected by flow cytometry. Data were analysed by Mann-Whitney U. Results: Gender differences were found in C3 (men: median 118.8, mean rank: 41.0; women: median: 143.9, mean rank: 65.7, p = 0.001) and ceruloplasmin (men: median: 31.01, mean rank: 47.06; women: median: 31.0, mean rank: 62.9, p = 0.015). Differences by BMI were found in C3 (women non-overweight: median: 137.00 mena rank: 36.52; women with risk of overweight/overweight: median: 175.80, mean rank: 57.69, p = 0.002) and C4 (men non-overweight: median: 23.40, mean rank: 16.60; men with risk of overweight/overweight: median: 26.40, mean rank: 26.36, p = 0.028; women non-overweight: median: 24.25, mean rank: 37.16 and women with risk of overweight/overweight: median: 32.80, mean rank: 54.42, p = 0.013). Conclusion: Inflammatory proteins are increased in adolescents with risk of overweight and overweight, particularly in women. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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3. Characterization of microbiota and histology of cultured sea cucumber Isostichopus badionotus juveniles during an outbreak of skin ulceration syndrome.
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Arjona-Cambranes KA, Olvera-Novoa MA, Cerqueda-García D, Arjona-Torres MG, Aguirre-Macedo ML, Vidal-Martínez VM, and García-Maldonado JQ
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- Animals, Aquaculture, RNA, Ribosomal, 16S genetics, Skin Ulcer microbiology, Skin Ulcer epidemiology, Skin Ulcer pathology, Disease Outbreaks, Gastrointestinal Microbiome, Microbiota, Skin microbiology, Skin pathology, Sea Cucumbers microbiology
- Abstract
Due to the dramatic reduction of sea cucumber Isostichopus badionotus populations in the Yucatan Peninsula by overfishing and poaching, aquaculture has been encouraged as an alternative to commercial catching and restoring wild populations. However, the scarcity of broodstock, the emergence of a new disease in the auricularia larvae stage, and the development of skin ulceration syndrome (SUS) in the culture have limited aquaculture development. This study presents the changes in the intestine and skin microbiota observed in early and advanced stages of SUS disease in cultured juvenile I. badionotus obtained during an outbreak in experimental culture through 16S rRNA gene sequencing and histological evidence. Our results showed inflammation in the intestines of juveniles at both stages of SUS. However, more severe tissue damage and the presence of bacterial clusters were detected only in the advanced stages of SUS. Differences in the composition and structure of the intestinal and skin bacterial community from early and advanced stages of SUS were detected, with more evident changes in the intestinal microbial communities. These findings suggest that SUS was not induced by a single pathogenic bacterium. Nevertheless, a decrease in the abundance of Vibrio and an increase in Halarcobacter (syn. Arcobacter) was observed, suggesting that these two bacterial groups could be keystone genera involved in SUS disease., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Arjona-Cambranes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2024
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4. Cyberaggression and cybervictimisation in adolescents: Bibliometric analysis in web of science.
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Fernández Herrerías AI, Jiménez Torres MG, Terrón PD, and Moreno Guerrero AJ
- Abstract
Worldwide new trends of online cyberbullying are emerging that impact on health and are a factor in adolescent suicide. The objective of this study is to know the development of scientific production and to compare the current trends that encompass the concepts of cyberaggression in young people (CAY) and cybervictimisation in young people (CVY). The methodology used in this study was descriptive with a bibliometric analysis on CAY with 481 documents and CVY with 1087 documents, in addition to a co-word analysis of both terms from the years 2017-2021. These data were extracted from the Web of Science database and network maps were made using VOSviewer software. The results show that the terms CAY and CVY were born in 2006 and have had a different evolutionary progression in the scientific literature until 2021, in addition, the area of psychology stands out with more research on other areas, developed countries are the ones that carry out more studies of CAY and CVY and that the term "suicide" is the most prominent term since 2018 from the CVY. Finally, a discussion and conclusion of the results was made, which can serve as a turning point for future lines of research., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors.)
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- 2023
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5. Advancements in Home-Based Devices for Detecting Obstructive Sleep Apnea: A Comprehensive Study.
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Espinosa MA, Ponce P, Molina A, Borja V, Torres MG, and Rojas M
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- Humans, Polysomnography methods, Sleep, Oximetry methods, Sleep Apnea, Obstructive diagnosis, Sleep Apnea Syndromes
- Abstract
Obstructive Sleep Apnea (OSA) is a respiratory disorder characterized by frequent breathing pauses during sleep. The apnea-hypopnea index is a measure used to assess the severity of sleep apnea and the hourly rate of respiratory events. Despite numerous commercial devices available for apnea diagnosis and early detection, accessibility remains challenging for the general population, leading to lengthy wait times in sleep clinics. Consequently, research on monitoring and predicting OSA has surged. This comprehensive paper reviews devices, emphasizing distinctions among representative apnea devices and technologies for home detection of OSA. The collected articles are analyzed to present a clear discussion. Each article is evaluated according to diagnostic elements, the implemented automation level, and the derived level of evidence and quality rating. The findings indicate that the critical variables for monitoring sleep behavior include oxygen saturation (oximetry), body position, respiratory effort, and respiratory flow. Also, the prevalent trend is the development of level IV devices, measuring one or two signals and supported by prediction software. Noteworthy methods showcasing optimal results involve neural networks, deep learning, and regression modeling, achieving an accuracy of approximately 99%.
- Published
- 2023
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6. Effectiveness of Cyanoacrylate in the Treatment of Dentin Hypersensitivity: A Systematic Review.
- Author
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Torres ADS, Martins OBL, Otoni RP, Henrique Soares K, Torres MG, Firoozi P, and Flecha OD
- Abstract
Objective: To compare the effectiveness of cyanoacrylate to other treatments or placebo in the management of dentin hypersensitivity (DH)., Materials and Methods: The present review was organized based on the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. The search aimed to answer the following question: is cyanoacrylate effective in the treatment of DH when compared to other treatments or placebo? The following databases were used: PubMed/MEDLINE, Scopus, BVS, Web of Science, Cochrane, Clinicaltrials.gov, Portal Periódicos Capes, Google Scholar, and manual search. The evaluation process started with the information collected from the selected articles according to the Consolidated Standards of Reporting Trials (CONSORT)., Results: Two randomized and five nonrandomized clinical trials were analyzed in the qualitative synthesis. The studies presented different cyanoacrylate formulations, different scales for evaluating pain, and different methods for provoking a painful stimulus. Cyanoacrylate-based products reduce DH in shorter follow-up periods and this reduction persisted throughout the study. The results varied according to the methods used to stimulate the pain. Only two articles showed a low risk of bias and a high level of scientific evidence., Conclusion: Although there is a limited number of studies in the scientific literature with appropriate methodological quality, the available evidence proves the effectiveness of cyanoacrylate in the treatment of DH. Clinical Relevance . Cyanoacrylate is easy to access, effective, easily applicable, and a low-cost product with satisfactory results., Competing Interests: The authors declare no competing interests., (Copyright © 2023 Adriana da Silva Torres et al.)
- Published
- 2023
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7. Development of a new low-cost computer vision system for human gait analysis: A case study.
- Author
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Bernal-Torres MG, Medellín-Castillo HI, and Arellano-González JC
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- Humans, Algorithms, Motion Capture, Artificial Intelligence, Biomechanical Phenomena, Gait, Gait Analysis
- Abstract
Today, human gait analysis is commonly used for clinical diagnosis, rehabilitation and performance improvement in sports. However, although previous research works in the literature address the use of motion capture systems by means of optoelectronic sensors, Inertial Measurement Units (IMUs) and depth cameras, few of them discuss their conception, guidelines and algorithms for measuring and calculating gait metrics. Moreover, commercially available motion capture systems, although efficient, are cost restrictive for most of the low-income institutions. In this research work, a new computer vision-based system (CVS) for gait analysis is developed and proposed. The aim is to close the gap found in the literature about the design and development of such systems by providing the requirements, considerations, algorithms and methodologies used to develop a gait analysis system with acceptable precision and accuracy, and at low cost. For this purpose, a linear computer vision method based on the non-homogeneous solution of the calibration matrix was used. The spatio-temporal and angular gait parameters were implemented in the proposed system, and compared with those reported in the literature. The denoising of the spatial gait trajectories and the strategies to detect gait events, are also presented and discussed. The results have shown that the proposed system is satisfactory for human gait analysis in terms of precision, computational performance and low cost.
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- 2023
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8. Anxiety Levels and Coping Strategies to Deal with COVID-19: A Cross-Cultural Study among the Spanish and Latin American Healthcare Populations.
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Olivencia-Carrión MA, Olivencia-Carrión MD, Fernández-Daza M, Zabarain-Cogollo S, Castro GP, and Jiménez-Torres MG
- Abstract
Given its impact, COVID-19 has engendered great challenges in terms of health, highlighting the key role of health personnel. This study aims to analyze the level of anxiety, as well as coping strategies, among the health personnel in Latin American countries and Spain. An exploratory, descriptive, quantitative, cross-sectional study was conducted with 584 participants from the healthcare population. No significant differences were observed in anxiety levels due to COVID-19 between Latin American countries and Spain. In Spain, an active and passive coping style is used, while in Latin American countries, an avoidance coping style is employed; there is a direct correlation between anxiety levels and the avoidance coping style. There exists an inverse correlation between anxiety levels and the use of an active coping style; moreover, there are no significant differences in the anxiety level of health personnel depending on whether they have cared for patients with COVID-19. Low cognitive activity, use of the avoidance method and Spanish geography were the main predictive coping styles of anxiety. Effective measures are required for preserving the mental health of health professionals during pandemics.
- Published
- 2023
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9. Evaluation of uranium and plutonium isotopes in marine samples from Veracruz coastline (Mexico).
- Author
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Ordóñez Regil E, Almazán Torres MG, and Fernández Valverde M
- Subjects
- Mexico, Sand, Plutonium analysis, Uranium analysis, Radiation Monitoring methods
- Abstract
Activity ratios (A.R.) of
234 U/238 U and activity concentration of238+234 U and239+240 Pu were measured in collected seawaters and sand beach samples from various locations along of littoral of Mexican state of Veracruz. Uranium and plutonium were separated and concentrated in a liquid-liquid partition chromatography, afterwards, detected and analyzed by means of alpha spectrometric technique. The234 U/238 U activity ratio (AR) ranges from 0.72 to 1.11 in sand beach and from 0.77 to 1.22 in seawater. The activity concentration was found in sea water from 0.31 to 1.94 Bq/L for234+238 U and from 15 to 137 μBq/L for239+240 Pu, in sand beach samples was found to be from 0.64 to 3.86 Bq/kg for234+238 U and from 33 to 249 μBq/kg for239+240 Pu., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022. Published by Elsevier Ltd.)- Published
- 2022
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10. Goal Setting with Latinx Families of Children with Intellectual and Developmental Disabilities: Case Studies.
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Suarez-Balcazar Y, Balcazar F, Torres MG, Garcia C, and Arias DL
- Abstract
Behavioral community psychology focuses on studying issues that matter to communities, unpacking contextual factors that impact people's behaviors, and identifying strategies to address such issues. Goal setting is one such strategy often used by behavioral psychologists. Grounded in the values of behavioral community psychology and a behavior analysis paradigm, this study illustrated two case studies of Latinx parents of children with disabilities where goal-setting strategies were implemented to promote behavior change. The first case study focused on the promotion of healthy lifestyle behaviors and routines among Latinx families of children with disabilities in the United States. The second case study examined goal setting related to youth development by parents of adolescents with disabilities in Colombia. In both cases, participants received training on goal setting and had opportunities to discuss progress toward achieving their goals, share action steps taken, and discuss the contextual challenges or barriers that they experienced. The results indicate that behavioral goal-setting procedures can be effective in helping parents attain their goals and brainstorm strategies for addressing behavioral and contextual challenges. Implications for future research advancing behavioral community psychology are discussed., Competing Interests: Conflict of InterestThe authors declare no conflict of interest., (© Association for Behavior Analysis International 2022.)
- Published
- 2022
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11. Reporting is not supporting: Why mandatory supporting, not mandatory reporting, must guide university sexual misconduct policies.
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Holland KJ, Hutchison EQ, Ahrens CE, and Torres MG
- Abstract
Competing Interests: The authors declare no competing interest.
- Published
- 2021
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12. Comparison of Transcatheter Pulmonic Valve Implantation With Surgical Pulmonic Valve Replacement in Adults (from the National Inpatient Survey Dataset).
- Author
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Chatterjee A, Bhatia N, Torres MG, Cribbs MG, Mauchley DC, and Law MA
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- Adult, Female, Follow-Up Studies, Heart Valve Diseases mortality, Hospital Mortality trends, Humans, Incidence, Male, Retrospective Studies, Survival Rate trends, Treatment Outcome, United States epidemiology, Cardiac Catheterization methods, Health Surveys, Heart Valve Diseases surgery, Heart Valve Prosthesis Implantation methods, Inpatients statistics & numerical data, Postoperative Complications epidemiology, Pulmonary Valve surgery
- Abstract
There are no large reports of comparative outcomes of transcatheter pulmonic valve implantation (TPVI) and surgical pulmonic valve replacement (SPVR). Prospective studies are unlikely to be feasible in the future also. Thus, we utilized a large adult inpatient database to compare the two with respect to temporal trends, in hospital outcomes and costs. Data from the National Inpatient Sample database from 2003 to 2014 was analyzed to extract patients who underwent TPVI and SPVR using unique ICD 9-CM codes. In-hospital outcomes and charges were then analyzed. All charges were converted to 2018 dollars and a loss of wages analysis was performed using the Bureau of Labor Statistics published median weekly wages. A total of 8,449 and 555 SPVR and TPVI discharges were identified. 5.8% SPVR procedures were done in rural setting versus 1.8% of TPVI. Complications including in-hospital mortality (2.3 vs 0.9%; p = 0.02) were higher in SPVR group. Length of stay was significantly shorter for the TPVI group (1 vs 5 days; p <0.001), which also contributed to lower loss of wages ($1028.57 vs $6042.86; p <0.001) with similar hospital charges. In conclusion, volumes of both TPVI and SPVR are increasing across adult hospitals in the United States, reflecting an overall increase in the adult congenital heart disease population. TPVI offers improved short-term outcomes and decreased loss of wages through shorter recovery time in this real-world database analysis., (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Published
- 2020
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13. Ethanol as a potential mosquito sample storage medium for RNA preservation.
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Torres MG, Weakley AM, Hibbert JD, Kirstein OD, Lanzaro GC, and Lee Y
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- Animals, Mosquito Vectors, Culicidae genetics, Ethanol, Preservation, Biological methods, RNA
- Abstract
Sample storage for downstream RNA analysis can be challenging in some field settings, especially where access to cryogenic materials or refrigeration/freezer facilities are limited. This has limited RNA-based studies on African malaria vectors collected in the field. We evaluated RNA quality after storing mosquito samples in three different sample preservation media over a 4-week period. Storing mosquito specimens in cold (4°C) media significantly improved yields of intact RNA. Our results indicate commercially available products perform well in keeping RNA integrity as advertised. Moreover, absolute ethanol may be an economical alternative for sample preservation that can be utilized in some resource-limited settings., Competing Interests: No competing interests were disclosed.
- Published
- 2019
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14. Temperament and characteristics related to nomophobia.
- Author
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Olivencia-Carrión MA, Ferri-García R, Rueda MDM, Jiménez-Torres MG, and López-Torrecillas F
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- Fear, Female, Humans, Male, Personality, Personality Inventory, Spain, Surveys and Questionnaires, Young Adult, Behavior, Addictive psychology, Cell Phone, Character, Ethnicity psychology, Phobic Disorders psychology, Temperament
- Abstract
Nomophobia is defined as the fear of being out of mobile phone contact and is considered to be a phobia of the modern age. The current study set out to establish the relationship between temperament and personality and the development of nomophobia. The sample was composed of 968 participants selected from the Andalusian population, of which there were 182 males and 785 females aged from 23.19 years. The instruments used were the Questionnaire to Assess Nomophobia (QANIP; Olivencia-Carrión et al., 2018) and the Temperament and Character Inventory Revised (TCI-R; Cloninger et al., 1993). We found that cooperation is a characteristic that significantly reduces nomophobic levels, particularly for the two factors of Mobile Phone Addiction and Negative Consequences. Furthermore, Reward Dependence appears to be positively related to two of the factors involved in nomophobia, namely Mobile Phone Addiction and Loss of Control, suggesting a relationship between Nomophobia and personality. These findings are discussed in terms of their usefulness for identifying the personality predictors of nomophobia in order to develop preventive and intervention strategies., (Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2018
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15. Design and Control of a New Biomimetic Transfemoral Knee Prosthesis Using an Echo-Control Scheme.
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Bernal-Torres MG, Medellín-Castillo HI, and Arellano-González JC
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- Adult, Biomechanical Phenomena physiology, Gait Analysis, Humans, Male, Young Adult, Biomimetics methods, Knee physiology, Knee Prosthesis, Prosthesis Design methods, Signal Processing, Computer-Assisted
- Abstract
Passive knee prostheses require a significant amount of additional metabolic energy to carry out a gait cycle, therefore affecting the natural human walk performance. Current active knee prostheses are still limited because they do not reply with accuracy of the natural human knee movement, and the time response is relatively large. This paper presents the design and control of a new biomimetic-controlled transfemoral knee prosthesis based on a polycentric-type mechanism. The aim was to develop a knee prosthesis able to provide additional power and to mimic with accuracy of the natural human knee movement using a stable control strategy. The design of the knee mechanism was obtained from the body-guidance kinematics synthesis based on real human walking patterns obtained from computer vision and 3D reconstruction. A biomechanical evaluation of the synthesized prosthesis was then carried out. For the activation and control of the prosthesis, an echo-control strategy was proposed and developed. In this echo-control strategy, the sound side leg is sensed and synchronized with the activation of the knee prosthesis. An experimental prototype was built and evaluated in a test rig. The results revealed that the prosthetic knee is able to mimic the biomechanics of the human knee.
- Published
- 2018
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16. Prevalence of prediabetes and modifiable factors in an ethnic group of Mexico: the Comcáac Project.
- Author
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Robles-Ordaz MD, Gallegos-Aguilar AC, Urquidez-Romero R, Diaz-Zavala RG, Lavandera-Torres MG, and Esparza-Romero J
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- Adult, Anthropometry, Blood Glucose metabolism, Cross-Sectional Studies, Exercise, Female, Glycated Hemoglobin metabolism, Humans, Male, Mexico epidemiology, Nutrition Assessment, Prevalence, Risk Factors, Socioeconomic Factors, Young Adult, Indians, Central American, Prediabetic State ethnology
- Abstract
Objective: To determine the prevalence of and modifiable factors associated with prediabetes in the Comcáac Indians., Design: Cross-sectional study where prediabetes was defined using fasting plasma glucose, 2 h plasma glucose and glycated Hb (HbA1c). Physical, anthropometric and biochemical measurements, medical record, socio-economic, dietary and physical activity information were collected. The modifiable factors associated with prediabetes were assessed using multiple logistic regression. Settings Comcáac Indian communities of Punta Chueca and El Desemboque, Sonora, Mexico., Subjects: Adults (n 227) aged 20 years or older., Results: The sex- and age-adjusted prevalence (95 % CI) of prediabetes was 47·1 (40·8, 53·5) % in the overall population; age-adjusted prevalence was 47·3 (35·6, 59·0) % in men and 46·7 (39·1, 54·3) % in women. The modifiable factors associated with a risk of prediabetes (OR; 95 % CI) were light-intensity physical activity (per 1 h/week increase: 1·04; 1·01, 1·07) and insulin resistance (homeostasis model assessment of insulin resistance score >6·1 v. <4·1: 4·62; 1·37, 15·51). Increased consumption of a traditional dietary pattern based on fish and seafood, low-fat cereals, fruits and vegetables was a protective factor (0·49; 0·31, 0·79). All variables were modelled together and adjusted for age and sex., Conclusions: The high prediabetes prevalence found in the Comcáac community is alarming because it represents a large number of people who are at risk for type 2 diabetes. The identification of modifiable factors associated with prediabetes that are specific to this population may be useful for designing effective strategies to prevent prediabetes.
- Published
- 2018
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17. A new study of the kinetics of curd production in the process of cheese manufacture.
- Author
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Muñoz SV, Torres MG, Guerrero FQ, and Talavera RR
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- Chymosin analysis, Chymosin metabolism, Hydrogen-Ion Concentration, Kinetics, Light, Particle Size, Scattering, Radiation, Temperature, Viscosity, Cheese, Food Handling methods
- Abstract
We studied the role played by temperature and rennet concentration in the coagulation process for cheese manufacture and the evaluation of their kinetics. We concluded that temperature is the main factor that determines the kinetics. The rennet concentration was unimportant probably due to the fast action of the enzyme chymosin. The Dynamic light scattering technique allowed measuring the aggregate's size and their formation kinetics. The volume fraction of solids was determined from viscosity measurements, showing profiles that are in agreement with the size profiles. The results indicate that the formation of the aggregates for rennet cheese is strongly dependent on temperature and rennet concentration. The results revealed that at 35·5 °C the volume fraction of solids has the maximum slope, indicating that at this temperature the curd is formed rapidly. The optimal temperature throughout the process was established. Second-order kinetics were obtained for the process. We observed a quadratic dependence between the rennet volume and the volume fraction of solids (curd), thereby indicating that the kinetics of the curd production should be of order two.
- Published
- 2017
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18. Transformation kinetics of fermented milk using Lactobacillus casei (Lc1) and Streptococcus thermophilus: comparison of results with other Inocula.
- Author
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Muñoz SV, Guerrero FQ, Torres MG, Castro MD, and Talavera RR
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- Animals, Food Handling methods, Kinetics, Lactic Acid biosynthesis, Lactobacillus delbrueckii metabolism, Lactobacillus johnsonii metabolism, Organophosphates metabolism, Polysaccharides, Bacterial biosynthesis, Yogurt microbiology, Fermentation, Lacticaseibacillus casei metabolism, Milk microbiology, Probiotics, Streptococcus thermophilus metabolism
- Abstract
Probiotic-based starter cultures are generally used to produce fermented milks with improved characteristics in the final product. In this study, Lactobacillus casei and Streptococcus thermophilus (Lc1-St) were used as the starter inoculum. The transformation kinetics and properties of the final product were compared with systems produced with other inocula. The Lc1-St inoculum delayed the production of lactic acid from 40 to 70 min (depending on temperature and concentration) when compared to Lactobacillus delbrueckii ssp. bulgaricus and Streptococcus thermophilus (Lb-St) and Lactobacillus johnsonii and Streptococcus thermophilus (La1-St). The Lc1-St inoculum reached the aggregation system faster (30-80 min) than Lb-St (120-210 min) and La1-St (160-220 min), however, the production of exopolysaccharides and organic phosphates was delayed as a consequence of the lack of synergy between Lc1 and St.
- Published
- 2017
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19. Uranium and plutonium in anoxic marine sediments of the Santiago River mouth (Eastern Pacific, Mexico).
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Almazán-Torres MG, Ordóñez-Regil E, and Ruiz-Fernández AC
- Subjects
- Mexico, Plutonium analysis, Seawater chemistry, Uranium analysis, Geologic Sediments chemistry, Radiation Monitoring, Rivers chemistry, Water Pollutants, Radioactive analysis
- Abstract
The uranium (U) and plutonium (Pu) content with depth in a sediment core collected in the continental shelf off the mouth of the Santiago River in the Mexican Pacific was studied to evaluate the contamination effects of the effluent of the Santiago-Lerma River as it moves into the sea. The large mass of terrestrial detritus delivered by the river influences the physicochemical and geochemical processes in the seafloor. Abnormal concentrations of U and Pu in sediments were examined as indicative of the effects of anoxic conditions. One of the indicators of pollution of seawater is the bacterial activity of the shallow seabed layer; and among the prevailing bacteria, the magnetotactic ones induce the formation of euhedral and framboidal shapes (pyrite). These pyrite entities are by-products of anoxic environments loaded with decomposing detrital material and are very abundant in the surface layers of the sediment core analyzed. The pyrite formation is the result of a biochemical reaction between iron and organic sulphur reduced by bacteria, and the pyrite entities precipitate to the seafloor. In the same upper zone of the profile,
238 U is readily immobilized, while234 U is oxidized and dissolved in seawater by the effect of hot atom chemistry. This may cause the activity ratio (AR)234 U/238 U disequilibrium (near 0.41). Furthermore, in the shallow layer of the sediment core, an abnormally high concentration of239+240 Pu was detected. In this upper layer, the activity concentrations found were 3.19 Bq kg-1 for238 U, 1.32 kg-1 for234 U and 2.78 Bq kg-1 for239+240 Pu. In the lower fractions of the sediment core, normal values of AR234 U/238 U (≈1) were found, with traces of239+240 Pu., (Copyright © 2016 Elsevier Ltd. All rights reserved.)- Published
- 2016
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20. Novel Poly(3-hydroxybutyrate-g-vinyl alcohol) Polyurethane Scaffold for Tissue Engineering.
- Author
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Reyes AP, Martínez Torres A, Carreón Castro Mdel P, Rodríguez Talavera JR, Muñoz SV, Aguilar VM, and Torres MG
- Subjects
- Animals, Astrocytes cytology, Cell Culture Techniques methods, Male, Mice, Astrocytes metabolism, Materials Testing, Polyesters chemistry, Polyvinyl Alcohol chemistry, Tissue Engineering, Tissue Scaffolds chemistry
- Abstract
The design of new synthetic grafted poly(3-hydroxybutyrate) as composite 3D-scaffolds is a convenient alternative for tissue engineering applications. The chemically modified poly(3-hydroxybutyrate) is receiving increasing attention for use as biomimetic copolymers for cell growth. As of yet, these copolymers cannot be used efficiently because of the lack of good mechanical properties. Here, we address this challenge, preparing a composite-scaffold of grafted poly(3-hydroxybutyrate) polyurethane for the first time. However, it is unclear if the composite structure and morphology can also offer a biological application. We obtained the polyurethane by mixing a polyester hydroxylated resin with polyisocyanate and the modified polyhydroxyalkanoates. The results show that the poly(3-hydroxybutyrate) grafted with poly(vinyl alcohol) can be successfully used as a chain extender to form a chemically-crosslinked thermosetting polymer. Furthermore, we show a proposal for the mechanism of the polyurethane synthesis, the analysis of its morphology and the ability of the scaffolds for growing mammalian cells. We demonstrated that astrocytes isolated from mouse cerebellum, and HEK293 can be cultured in the prepared material, and express efficiently fluorescent proteins by adenoviral transduction. We also tested the metabolism of Ca(2+) to obtain evidence of the biological activity.
- Published
- 2016
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21. Morphometric features of the mandibular condyle and association with disk abnormalities.
- Author
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Torres MG, Crusoé-Rebello IM, Rosário M, Albuquerque MC, and Campos PS
- Subjects
- Cross-Sectional Studies, Female, Humans, Male, Mandibular Condyle pathology, Retrospective Studies, Temporomandibular Joint Disorders pathology, Magnetic Resonance Imaging, Mandibular Condyle diagnostic imaging, Temporomandibular Joint Disorders diagnostic imaging
- Abstract
Objective: The aim of this study was to evaluate the relationship between the morphometric characteristics of the condyle and temporomandibular joint (TMJ) disk displacement., Study Design: One hundred and nine individuals who underwent magnetic resonance imaging of the TMJ were evaluated. Linear (D1: condyle width; D2: condyle thickness) and angular (A1: horizontal condylar angle; A2: anterior condylar angle; A3: medial condylar angle) measurements were made. These measurements were associated with articular disk displacement, with and without reduction., Results: There was statistically significant association between limited D1 and D2 and between A1 above and A1 below the mean and displacement of the joint disk. There was statistically significant association between A2 and anterior displacement of the disk. Furthermore, thicker condyles and/or condyles with smaller horizontal angles and/or with smaller medial angles were associated with articular disk reduction., Conclusions: The morphometric characteristics of the bony components of the TMJ are related to articular disk displacement and with its reduction or nonreduction., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
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22. Growth of hydroxyapatite on the cellular membrane of the bacterium Bacillus thuringiensis for the preparation of hybrid biomaterials.
- Author
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Cervantes ER, Torres MG, Muñoz SV, Rosas ER, Vázquez C, and Talavera RR
- Subjects
- Bacillus thuringiensis metabolism, Biocompatible Materials chemistry, Durapatite chemistry, Bacillus thuringiensis cytology, Biocompatible Materials metabolism, Biomimetics methods, Durapatite metabolism
- Abstract
This study aimed to grow hydroxyapatite (HAp) crystals on the cellular wall of the Gram-positive bacterium Bacillus thuringiensis using a bio-mimetic method. Several strains were phenotypically and genotypically characterized using multilocus sequence typing (MLST) gene markers to differentiate the strains and confirm the identity of the isolated species to guarantee that the selected species was not harmful to human health or the environment. Three of the analyzed strains were selected because they exhibited the best nucleation and growth of HAp on the bacterial surface. This innovative method to grow HAp crystals on a cellular membrane helps to elucidate the mechanisms by which osseous tissue is formed in nature. The optimum concentration for the simulated physiological fluid (SPF) was 1.5×. The hybrid materials were characterized by optical microscopy, atomic force microscopy (AFM), scanning electron microscopy (SEM), X-ray powder diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR)., (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Published
- 2016
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23. Radiation-induced graft polymerization of chitosan onto poly(3-hydroxybutyrate).
- Author
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Torres MG, Muñoz SV, Rosales SG, Carreón-Castro Mdel P, Muñoz RA, González RO, González MR, and Talavera RR
- Subjects
- Models, Molecular, Molecular Conformation, Radiochemistry, Chitosan chemistry, Hydroxybutyrates chemistry, Polyesters chemistry, Polymerization
- Abstract
Chitosan is among the most studied biopolymers and offers important advantages, such as biodegradability, biocompatibility and nontoxicity. In this study, this polysaccharide was grafted onto poly(3-hydroxybutyrate) using the simultaneous gamma-irradiation-initiated polymerization method. The polyester was immersed in diverse solvents, which allowed the preparation of graft copolymers with different yields and crystallinities. A successful synthesis and the estimation of the degree of crystallinity were verified by spectroscopic and calorimetric techniques. The most suitable method was found to be the thermoanalytical approach because it displayed a linear relationship between the degree of crystallinity and the increasing degree of grafting. The results also indicated that the lowest degree of grafting was seen for acetic acid (14.27%), while the highest degree corresponded to ethyl acetate (32.11%). The mechanism of grafting was proposed on the basis of the experimental results., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Published
- 2015
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24. Branch of the canalis sinuosus: a rare anatomical variation--a case report.
- Author
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Torres MG, de Faro Valverde L, Vidal MT, and Crusoé-Rebello IM
- Subjects
- Dental Implants, Female, Humans, Maxilla diagnostic imaging, Maxillary Nerve diagnostic imaging, Middle Aged, Palate, Hard anatomy & histology, Palate, Hard diagnostic imaging, Preoperative Care methods, Rare Diseases, Anatomic Variation, Cone-Beam Computed Tomography methods, Maxilla anatomy & histology, Maxillary Nerve anatomy & histology
- Abstract
The canalis sinuosus (CS) is a neurovascular canal, a branch of the infraorbital canal through which the anterior superior alveolar nerve passes. There are no studies or case reports of anatomical variations related to this canal. A rare case of anatomical variation in the CS is reported that was detected by cone beam computed tomography done in a 47-year-old female as a pre-operative workup before dental implants. In this case, in the region slightly medial to tooth 23, a wide accessory branch from the CS was observed, running an intraosseous course in the inferior and posterior direction up to a foramen located in the hard palate, slightly medial in relation to tooth 23. The location of this branching, as well as its neurovascular component, is important for dental implant planning because of its proximity to the upper teeth. Identification of neurovascular bundles is fundamental to avoid complications for the patient.
- Published
- 2015
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25. Cytomegalovirus Immediate-Early Proteins Promote Stemness Properties in Glioblastoma.
- Author
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Soroceanu L, Matlaf L, Khan S, Akhavan A, Singer E, Bezrookove V, Decker S, Ghanny S, Hadaczek P, Bengtsson H, Ohlfest J, Luciani-Torres MG, Harkins L, Perry A, Guo H, Soteropoulos P, and Cobbs CS
- Subjects
- Animals, Antigens, Viral genetics, Apoptosis genetics, Brain Neoplasms metabolism, Cytomegalovirus genetics, Cytomegalovirus pathogenicity, Cytomegalovirus Infections pathology, Disease Models, Animal, Gene Knockdown Techniques, Glioblastoma metabolism, Glioma genetics, Glioma pathology, Humans, Immediate-Early Proteins genetics, Mice, Inbred BALB C, MicroRNAs genetics, MicroRNAs metabolism, Neoplastic Stem Cells pathology, Neoplastic Stem Cells virology, SOXB1 Transcription Factors genetics, SOXB1 Transcription Factors metabolism, Tumor Cells, Cultured, Antigens, Viral metabolism, Brain Neoplasms pathology, Brain Neoplasms virology, Glioblastoma pathology, Glioblastoma virology, Immediate-Early Proteins metabolism
- Abstract
Glioblastoma (GBM) is the most common and aggressive human brain tumor. Human cytomegalovirus (HCMV) immediate-early (IE) proteins that are endogenously expressed in GBM cells are strong viral transactivators with oncogenic properties. Here, we show how HCMV IEs are preferentially expressed in glioma stem-like cells (GSC), where they colocalize with the other GBM stemness markers, CD133, Nestin, and Sox2. In patient-derived GSCs that are endogenously infected with HCMV, attenuating IE expression by an RNAi-based strategy was sufficient to inhibit tumorsphere formation, Sox2 expression, cell-cycle progression, and cell survival. Conversely, HCMV infection of HMCV-negative GSCs elicited robust self-renewal and proliferation of cells that could be partially reversed by IE attenuation. In HCMV-positive GSCs, IE attenuation induced a molecular program characterized by enhanced expression of mesenchymal markers and proinflammatory cytokines, resembling the therapeutically resistant GBM phenotype. Mechanistically, HCMV/IE regulation of Sox2 occurred via inhibition of miR-145, a negative regulator of Sox2 protein expression. In a spontaneous mouse model of glioma, ectopic expression of the IE1 gene (UL123) specifically increased Sox2 and Nestin levels in the IE1-positive tumors, upregulating stemness and proliferation markers in vivo. Similarly, human GSCs infected with the HCMV strain Towne but not the IE1-deficient strain CR208 showed enhanced growth as tumorspheres and intracranial tumor xenografts, compared with mock-infected human GSCs. Overall, our findings offer new mechanistic insights into how HCMV/IE control stemness properties in GBM cells., (©2015 American Association for Cancer Research.)
- Published
- 2015
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26. Accessory mental foramen: A rare anatomical variation detected by cone-beam computed tomography.
- Author
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Torres MG, Valverde Lde F, Vidal MT, and Crusoé-Rebello IM
- Abstract
The mental foramen is a bilateral opening in the vestibular portion of the mandible through which nerve endings, such as the mental nerve, emerge. In general, the mental foramen is located between the lower premolars. This region is a common area for the placement of dental implants. It is very important to identify anatomical variations in presurgical imaging exams since damage to neurovascular bundles may have a direct influence on treatment success. In the hemimandible, the mental foramen normally appears as a single structure, but there are some rare reports on the presence and number of anatomical variations; these variations may include accessory foramina. The present report describes the presence of accessory mental foramina in the right mandible, as detected by cone-beam computed tomography before dental implant placement.
- Published
- 2015
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27. Nanoparticles of KFeP2O7 implanted on silica gel beads for Cd2+ ion adsorption.
- Author
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Ordoñez-Regil E, Granados-Correa F, Ordoñez-Regil E, and Almazán-Torres MG
- Subjects
- Adsorption, Cadmium chemistry, Computer Simulation, Ions, Metal Nanoparticles ultrastructure, Microspheres, Models, Chemical, Particle Size, Water Pollutants, Chemical chemistry, Water Purification methods, Cadmium isolation & purification, Iron Compounds chemistry, Metal Nanoparticles chemistry, Phosphates chemistry, Potassium Compounds chemistry, Silica Gel chemistry, Water Pollutants, Chemical isolation & purification
- Abstract
Nanoparticles of iron and potassium diphosphate (KFeP2O7) implanted in silica gel beads (SiO2) have been investigated as an alternative adsorbent for removing Cd2+ ions from aqueous solutions. Batch adsorption experiments were conducted as a function of contact time, adsorbent dosage, initial cadmium ion concentration, solution pH, and temperature. Kinetic and thermodynamic studies on the cadmium adsorption onto KFeP2O7/SiO2 include a complete analysis and discussion. The equilibrium data were well described by the Freundlich isotherm model. The adsorption kinetic of cadmium on KFeP2O7/SiO2 followed a pseudo-first-order kinetic model obtained by using nonlinear regression analysis. Thermodynamic parameters (enthalpy change, free energy change, and entropy change) indicated that the Cd2+ adsorption process was spontaneous and exothermic in nature. The results showed that the studied KFeP2O7 nanomaterial implanted in silica is an effective adsorbent for cadmium ion removal from wastewater.
- Published
- 2015
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28. Exposure to the polyester PET precursor--terephthalic acid induces and perpetuates DNA damage-harboring non-malignant human breast cells.
- Author
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Luciani-Torres MG, Moore DH, Goodson WH 3rd, and Dairkee SH
- Subjects
- Antineoplastic Agents, Hormonal pharmacology, Apoptosis drug effects, Blotting, Western, Breast drug effects, Breast Neoplasms metabolism, Cell Cycle drug effects, Cell Proliferation drug effects, Cells, Cultured, Estrogen Receptor alpha metabolism, Estrogen Receptor beta metabolism, Female, Free Radical Scavengers adverse effects, Humans, Tamoxifen pharmacology, Breast pathology, Breast Neoplasms chemically induced, Breast Neoplasms pathology, DNA Damage drug effects, Drug Resistance, Neoplasm drug effects, Phthalic Acids adverse effects, Polyethylene Terephthalates adverse effects
- Abstract
Identification of early perturbations induced in cells from non-cancerous breast tissue is critical for understanding possible breast cancer risk from chemical exposure. We have demonstrated previously that exposure to the ubiquitous xenoestrogens, bisphenol A (BPA) and methyl paraben, promotes the hallmarks of cancer in non-malignant human high-risk donor breast epithelial cells (HRBECs) isolated from several donors. Here we show that terephthalic acid (TPA), a major chemical precursor of polyethylene terephthalate (PET) containers used for the storage of food and beverages, increased the ERα: ERβ ratio in multiple HRBEC samples, suggesting an estrogenic effect. Although, like BPA and methyl paraben, TPA also promoted resistance to tamoxifen-induced apoptosis, unlike these chemicals instead of inducing an increased S-phase fraction, TPA treatment arrested cell proliferation. DNA-PK, ATM and members of the MRN complex, known to be involved in DNA damage sensor and effector proteins, were elevated indicating induction of DNA strand breaks. Early DNA damage checkpoint response, mediated through p53/p21, led to G1 arrest in TPA-exposed cells. Removal of TPA from the growth medium resulted in the rapid induction of BCL2, increasing the ratio of anti-: pro-apoptotic proteins, together with overexpression of Cyclin A/CDK2 proteins. Consequently, despite elevated p53(pSer15) and H2AX(pSer139), indicating sustained DNA damage, TPA exposed cells resumed robust growth rates seen prior to TPA exposure. The propensity for the perpetuation of DNA aberrations that activate DNA damage pathways in non-malignant breast cells justifies careful consideration of human exposure to TPA, particularly at vulnerable life stages., (© The Author 2014. Published by Oxford University Press.)
- Published
- 2015
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29. Survival of Mexican Children with Acute Lymphoblastic Leukaemia under Treatment with the Protocol from the Dana-Farber Cancer Institute 00-01.
- Author
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Jiménez-Hernández E, Jaimes-Reyes EZ, Arellano-Galindo J, García-Jiménez X, Tiznado-García HM, Dueñas-González MT, Martínez Villegas O, Sánchez-Jara B, Bekker-Méndez VC, Ortíz-Torres MG, Ortíz-Fernández A, Marín-Palomares T, and Mejía-Aranguré JM
- Subjects
- Adolescent, Child, Child, Preschool, Cytarabine administration & dosage, Female, Humans, Infant, Male, Methotrexate administration & dosage, Mexico, Neoplasm Recurrence, Local epidemiology, Neoplasm Recurrence, Local pathology, Precursor Cell Lymphoblastic Leukemia-Lymphoma epidemiology, Precursor Cell Lymphoblastic Leukemia-Lymphoma pathology, Prednisone administration & dosage, Risk Factors, Treatment Outcome, United States, Vincristine administration & dosage, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Disease-Free Survival, Neoplasm Recurrence, Local drug therapy, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
- Abstract
Our aim in this paper is to describe the results of treatment of acute lymphoblastic leukaemia (ALL) in Mexican children treated from 2006 to 2010 under the protocol from the Dana-Farber Cancer Institute (DFCI) 00-01. The children were younger than 16 years of age and had a diagnosis of ALL de novo. The patients were classified as standard risk if they were 1-9.9 years old and had a leucocyte count <50 × 10(9)/L, precursor B cell immunophenotype, no mediastinal mass, CSF free of blasts, and a good response to prednisone. The rest of the patients were defined as high risk. Of a total of 302 children, 51.7% were at high risk. The global survival rate was 63.9%, and the event-free survival rate was 52.3% after an average follow-up of 3.9 years. The percentages of patients who died were 7% on induction and 14.2% in complete remission; death was associated mainly with infection (21.5%). The relapse rate was 26.2%. The main factor associated with the occurrence of an event was a leucocyte count >100 × 10(9)/L. The poor outcomes were associated with toxic death during induction, complete remission, and relapse. These factors remain the main obstacles to the success of this treatment in our population.
- Published
- 2015
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30. Unilateral bony ankylosis of the temporomandibular joint in a case of ankylosing spondylitis.
- Author
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de Andrade Freitas Oliveira LS, de Oliveira-Santos C, de Melo DP, Gomes Torres MG, and Flores Campos PS
- Subjects
- Adult, Ankylosis surgery, Arthroplasty, Replacement, Follow-Up Studies, Humans, Male, Postoperative Complications diagnosis, Radiography, Panoramic, Spondylitis, Ankylosing surgery, Temporomandibular Joint Disc surgery, Temporomandibular Joint Disorders surgery, Tomography, X-Ray Computed, Ankylosis diagnosis, Spondylitis, Ankylosing diagnosis, Temporomandibular Joint Disorders diagnosis
- Abstract
Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease with multiple articular and para-articular involvement that has a predilection for the axial skeleton. In spite of its high prevalence, ankylosis secondary to AS is a rare condition., Case Report: A 31-year-old male diagnosed with AS was referred for computed tomography (CT) of the temporomandibular joint (TMJ) due to severe mouth opening limitation. The patient had a 16-year medical history of AS and sought assistance due to TMJ pain and incapacity to open his mouth., Results: Previous bony scintigraphy revealed involvement of the spine, sacroiliac joints, right knee, and left TMJ. Magnetic resonance imaging revealed erosion of the left condyle and posterior slope of the articular eminence, and a mass of heterogeneous signal intensity between these structures. The left condyle also presented sclerosis/edema of the bone marrow and the disk could not be identified. Sagittal and coronal CT images showed moderate alterations of the TMJ on the right side. On the left side, the images displayed markedly eroded condyle and mandibular fossa, and a bony mass resulting in ankylosis of the osseous components of the joint., Conclusion: TMJ ankylosis in AS patients is rare and very few reports have presented imaging features of the condition through advanced diagnostic techniques.
- Published
- 2013
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31. Biometric parameters of the temporomandibular joint and association with disc displacement and pain: a magnetic resonance imaging study.
- Author
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Vieira-Queiroz I, Gomes Torres MG, de Oliveira-Santos C, Flores Campos PS, and Crusoé-Rebello IM
- Subjects
- Adolescent, Adult, Aged, Biometry, Case-Control Studies, Female, Humans, Joint Dislocations complications, Magnetic Resonance Imaging, Male, Middle Aged, Young Adult, Facial Pain etiology, Joint Dislocations pathology, Mandibular Condyle pathology, Temporomandibular Joint pathology, Temporomandibular Joint Disc pathology, Temporomandibular Joint Disorders pathology
- Abstract
The aim of this study was to evaluate the relationship between biometric parameters of the components of the temporomandibular joint (TMJ), articular disc displacement, and TMJ pain. Magnetic resonance imaging (MRI) examinations of 185 patients were assessed (39 males and 146 females (370 TMJs), mean age 41.3 years, range 18-79 years). The antero-posterior length of the condyle was measured in its medial and lateral regions, as well as the transverse length of the condyle. Possible associations between linear measurements of the condyle, presence of disc displacement, and joint pain were tested. Although pain was more commonly reported among patients with disc displacements, this association was not statistically significant. We found statistically significant associations showing that the antero-posterior length of the condyle at the lateral pole (D1L), the antero-posterior length of the condyle at the medial pole (D1M), and the transverse length of the condyle (D2) were higher among patients without disc displacements when compared to those with unilateral or bilateral displacements. This study showed that disc displacement was associated with smaller condyles in the antero-posterior and transverse dimensions when compared to condyles in subjects with normal disc position., (Copyright © 2013 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2013
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32. Bisphenol-A-induced inactivation of the p53 axis underlying deregulation of proliferation kinetics, and cell death in non-malignant human breast epithelial cells.
- Author
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Dairkee SH, Luciani-Torres MG, Moore DH, and Goodson WH 3rd
- Subjects
- Apoptosis Regulatory Proteins metabolism, Benzhydryl Compounds pharmacology, Breast Neoplasms, Cell Cycle drug effects, Cell Cycle Proteins metabolism, Cell Survival drug effects, Curcumin pharmacology, Down-Regulation drug effects, Epithelial Cells drug effects, Epithelial Cells metabolism, Estrogen Receptor alpha agonists, Estrogen Receptor alpha metabolism, Estrogens, Non-Steroidal pharmacology, Female, Humans, Hydroxytestosterones pharmacology, Kinetics, Phenols pharmacology, Primary Cell Culture, Signal Transduction, TOR Serine-Threonine Kinases metabolism, Tumor Suppressor Protein p53 genetics, Apoptosis, Cell Proliferation drug effects, Epithelial Cells physiology, Mammary Glands, Human pathology, Tumor Suppressor Protein p53 metabolism
- Abstract
Widespread distribution of bisphenol-A (BPA) complicates epidemiological studies of possible carcinogenic effects on the breast because there are few unexposed controls. To address this challenge, we previously developed non-cancerous human high-risk donor breast epithelial cell (HRBEC) cultures, wherein BPA exposure could be controlled experimentally. BPA consistently induced activation of the mammalian target of rapamycin (mTOR) pathway--accompanied by dose-dependent evasion of apoptosis and increased proliferation--in HRBECs from multiple donors. Here, we demonstrate key molecular changes underlying BPA-induced cellular reprogramming. In 3/3 BPA-exposed HRBEC cell lines, and in T47D breast cancer cells, proapoptotic negative regulators of the cell cycle (p53, p21(WAF1) and BAX) were markedly reduced, with concomitant increases in proliferation-initiating gene products (proliferating cell nuclear antigen, cyclins, CDKs and phosphorylated pRb). However, simultaneous exposure to BPA and the polyphenol, curcumin, partially or fully reduced the spectrum of effects associated with BPA alone, including mTOR pathway proteins (AKT1, RPS6, pRPS6 and 4EBP1). BPA exposure induced an increase in the ERα (Estrogen Receptor): ERβ ratio--an effect also reversed by curcumin (analysis of variance, P < 0.02 for all test proteins). At the functional level, concurrent curcumin exposure reduced BPA-induced apoptosis evasion and rapid growth kinetics in all cell lines to varying degrees. Moreover, BPA extended the proliferation potential of 6/6 primary finite-life HRBEC cultures--another effect reduced by curcumin. Even after removal of BPA, 1/6 samples maintained continuous growth--a hallmark of cancer. We show that BPA exposure induces aberrant expression of multiple checkpoints that regulate cell survival, proliferation and apoptosis and that such changes can be effectively ameliorated.
- Published
- 2013
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33. Evaluation of panoramic radiomorphometric indices related to low bone density in sickle cell disease.
- Author
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Neves FS, Oliveira LS, Torres MG, Toralles MB, da Silva MC, Campos MI, Campos PS, and Crusoé-Rebello I
- Subjects
- Adult, Age Factors, Female, Humans, Male, Mandible diagnostic imaging, Middle Aged, Radiography, Panoramic methods, Young Adult, Anemia, Sickle Cell complications, Osteoporosis diagnostic imaging, Osteoporosis etiology
- Abstract
Summary: In sickle cell disease, erythroid hyperplasia causes trabecular destruction leading to low bone density. This condition could be suspected by the radiomorphometric indices and your diagnosis becomes relevant in a multidisciplinary context of health care for sickle cell subjects, providing prognostics and contributing to determine adequate therapeutic and preventive actions., Introduction: The aim of this study was to assess the risk of low bone density in subjects with sickle cell disease (SCD) through analysis of panoramic radiographic exams by radiomorphometric indices., Methods: Seventy-eight Brazilian subjects with SCD took part in this study and were subdivided into four groups: (I) 31 SCD subjects aged under 40 years; (II) 13 SCD subjects aged 40 years or more; (III) 12 normal subjects aged under 40 years; and (IV) 22 normal subjects aged 40 years or more. In the panoramic radiographs, the mandibular cortical index (MCI) classification, increased spacing of the trabecular bone, panoramic mandibular index (PMI), and mental index (MI) were evaluated. Exact Fisher's test was used to compare age between the different groups. Descriptive analysis of the data was performed to evaluate the simple visual estimation of low bone density (increased bone trabecular space and MCI), and a one-way analysis of variance (Bonferroni criteria) was used to compare the means of the quantitative indices (PMI and MI). The significance level was p < 0.05., Results: In the MCI classification, C2 was more prevalent, especially in groups I and IV. Increased spacing of the trabecular bone was more frequent in groups I and II. MI did not show a statistically significant difference among the groups. PMI showed a statistically significant difference only between groups III and IV., Conclusions: The radiomorphometric indices applied in the present study can be used on panoramic radiographs to detect the presence of low bone density in SCD subjects.
- Published
- 2012
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34. Loss of cell-surface laminin anchoring promotes tumor growth and is associated with poor clinical outcomes.
- Author
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Akhavan A, Griffith OL, Soroceanu L, Leonoudakis D, Luciani-Torres MG, Daemen A, Gray JW, and Muschler JL
- Subjects
- Cell Line, Tumor, Cell Proliferation, Disease Progression, Dystroglycans metabolism, Extracellular Matrix metabolism, Glycosylation, Humans, N-Acetylglucosaminyltransferases metabolism, Cell Membrane metabolism, Laminin metabolism, Neoplasms metabolism
- Abstract
Perturbations in the composition and assembly of extracellular matrices (ECM) contribute to progression of numerous diseases, including cancers. Anchoring of laminins at the cell surface enables assembly and signaling of many ECMs, but the possible contributions of altered laminin anchoring to cancer progression remain undetermined. In this study, we investigated the prominence and origins of defective laminin anchoring in cancer cells and its association with cancer subtypes and clinical outcomes. We found loss of laminin anchoring to be widespread in cancer cells. Perturbation of laminin anchoring originated from several distinct defects, which all led to dysfunctional glycosylation of the ECM receptor dystroglycan. In aggressive breast and brain cancers, defective laminin anchoring was often due to suppressed expression of the glycosyltransferase LARGE. Reduced expression of LARGE characterized a broad array of human tumors in which it was associated with aggressive cancer subtypes and poor clinical outcomes. Notably, this defect robustly predicted poor survival in patients with brain cancers. Restoring LARGE expression repaired anchoring of exogenous and endogenous laminin and modulated cell proliferation and tumor growth. Together, our findings suggest that defects in laminin anchoring occur commonly in cancer cells, are characteristic of aggressive cancer subtypes, and are important drivers of disease progression., (©2012 AACR.)
- Published
- 2012
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35. Accuracy of linear measurements in cone beam computed tomography with different voxel sizes.
- Author
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Torres MG, Campos PS, Segundo NP, Navarro M, and Crusoé-Rebello I
- Subjects
- Alveolar Bone Loss diagnostic imaging, Anatomic Landmarks diagnostic imaging, Calibration, Dental Arch diagnostic imaging, Dental Implantation, Endosseous, Fiducial Markers, Humans, Jaw, Edentulous diagnostic imaging, Patient Care Planning standards, Cephalometry standards, Cone-Beam Computed Tomography standards, Image Processing, Computer-Assisted standards, Mandible diagnostic imaging
- Abstract
Objective: To evaluate the accuracy of linear measurements on dry mandible specimens using cone beam computed tomography (CBCT) images acquired with different voxel sizes., Methodology: Eight human dry mandibles were submitted to CBCT examination, using the i-CAT (Imaging Sciences, Inc. Hatfield, PA) device and four protocols with different voxel sizes. Tomographic slices with a more central view of the markers, placed on six sites on each mandible, were selected to perform measurements. Values obtained from direct measurements on the dry mandible after sectioning them on the preestablished sites were compared with measurements from the tomographic images and the measurement error., Results: There was no statistical difference between the measurement error of the protocols (P = 0.606). The mean value of the difference between the values obtained in the images and the dry mandible was smaller than 1 mm for all the protocols., Conclusion: The accuracy of vertical and horizontal measurements, using CBCT (i-CAT) for the four protocols, was shown to be comparable with the measurements performed on the dry mandible.
- Published
- 2012
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36. Assessment of enamel-dentin caries lesions detection using bitewing PSP digital images.
- Author
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Torres MG, Santos Ada S, Neves FS, Arriaga ML, Campos PS, and Crusoé-Rebello I
- Subjects
- Adolescent, Age Distribution, Chi-Square Distribution, Child, Dental Enamel diagnostic imaging, Dental Enamel pathology, Dentin diagnostic imaging, Dentin pathology, Female, Humans, Image Processing, Computer-Assisted methods, Male, Radiography, Bitewing, Reproducibility of Results, Sex Distribution, Surface Properties, Dental Caries diagnostic imaging, Phosphorus, Radiography, Dental, Digital methods
- Abstract
Objectives: The aim of this study was to evaluate the detection of enamel-dentin occlusal caries using photostimulable phosphor plates., Material and Methods: The ability to detect enamel-dentin occlusal caries in 607 premolars and molars from 47 patients between 10 and 18 years old, referred to the School of Dentistry of the Federal University of Bahia, Brazil, was evaluated based on clinical and radiographic examinations, using the criteria proposed in a previous study. A total of 156 bitewing digital images were obtained using Digora® (Soredex Medical Systems, Helsinki, Finland) phosphor plates. The plates were scanned and the images were captured and displayed on a computer screen. Image evaluation was done using Digora® for Windows 2.1 software, Soredex®. The radiologists were allowed to use enhancement tools to obtain better visibility during scoring of the teeth based on the radiographic criteria proposed in a previous study. Descriptive analysis and chi-squared proportion tests were done at 5% significance level., Results: The results of clinical examination showed a higher prevalence of teeth with a straight dark line or demineralization of the occlusal fissure (score 1) and a lower prevalence of sealed teeth (score 5). In the bitewing digital images, 47 teeth presented visible radiolucency, circumscribed, in dentin under occlusal enamel (enamel-dentin caries lesions)., Conclusions: Correlating the clinical and radiographic findings, it was found that in the majority of teeth diagnosed by radiographic images as having enamel-dentin caries, no caries could be detected by clinical examination.
- Published
- 2011
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37. Ecological composition and distribution of the diatoms from the Laguna Superior, Oaxaca, Mexico.
- Author
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Moreno-Ruiz JL, Tapia-Garcia M, Licea S, Figueroa-Torres MG, Esquivel A, Herrera-Galindo JE, González-Fernández JM, and González-Macias Mdel C
- Subjects
- Demography, Mexico, Pacific Ocean, Species Specificity, Diatoms physiology, Ecosystem
- Abstract
A taxonomic study of diatoms was carried out in a tropical coastal lagoon. Material for this study consists of water samples obtained from February-March 1992 to November-December 2000. Qualitative and quantitative analyses showed the presence of 373 taxa of which the families Bacillariaceae (67 species) and Chaetocerotaceae (37 species) were the most abundant groups. The species Skeletonema costatum, Chaetoceros curvisetus, Coscinodiscus radiatus var. radiatus, Ditylum brightwellii, Thalassiosira eccentrica and Entomoneis alata were found associated with moderate water quality and forming blooms. In addition, a regional comparison between Mexico and South America of the identified species is given. For practical handling, indicative values obtained from their ecological composition are incorporated as well as a code of the floristic list. Achecklist of the species and their occurrence are given.
- Published
- 2011
38. Fusogenics: a recombinant immunotoxin-based screening platform to select internalizing tumor-specific antibody fragments.
- Author
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Cizeau J, Torres MG, Cowling SG, Stibbard S, Premsukh A, Entwistle J, and MacDonald GC
- Subjects
- ADP Ribose Transferases genetics, ADP Ribose Transferases isolation & purification, Antibodies, Neoplasm biosynthesis, Antibodies, Neoplasm isolation & purification, Apoptosis, Bacterial Toxins genetics, Bacterial Toxins isolation & purification, Cell Line, Tumor, Escherichia coli, Exotoxins genetics, Exotoxins isolation & purification, Gene Library, High-Throughput Screening Assays, Humans, Immunoglobulin Fragments biosynthesis, Immunoglobulin Fragments genetics, Immunoglobulin Fragments isolation & purification, Neoplasms immunology, Neoplasms therapy, Organ Specificity, Recombinant Fusion Proteins biosynthesis, Recombinant Fusion Proteins genetics, Recombinant Fusion Proteins isolation & purification, Virulence Factors genetics, Virulence Factors isolation & purification, Pseudomonas aeruginosa Exotoxin A, Drug Screening Assays, Antitumor methods, Immunotoxins genetics, Immunotoxins immunology, Immunotoxins isolation & purification
- Abstract
Antibody-based therapeutics play a vital role in the treatment of certain cancers; however, despite commercial success, various strategies are being pursued to increase their potency and hence improve patient outcomes. The use of antibodies to deliver a cytotoxic payload offers a promising alternative for more efficacious therapies. Immunotoxins are composed of an internalizing antibody fragment linked to a bacterial or plant toxin. Once internalized, the payload, such as Pseudomonas exotoxin A (PE), blocks protein synthesis and induces apoptosis. Typically, immunotoxins are developed by first isolating a tumor-specific antibody, which is then either chemically linked to a toxin or reengineered as a fusion protein. Here, the authors describe the development of Fusogenics, an immunotoxin-based screening method that selects internalizing tumor-specific antibodies using a functional assay. Selected immune library clones were characterized and shown to be selective against normal tissues and specific to tumor tissues. In summary, the Fusogenics immunotoxin platform represents a unique, single-step selection approach combining specificity and functionality to isolate novel internalizing tumor-specific antibody fragments with potential for direct clinical application in the treatment of cancer.
- Published
- 2011
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39. Lingual accessory mental foramen: a report of an extremely rare anatomical variation.
- Author
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Neves FS, Torres MG, Oliveira C, Campos PS, and Crusoé-Rebello I
- Subjects
- Chin diagnostic imaging, Humans, Male, Mandibular Nerve diagnostic imaging, Middle Aged, Tomography, X-Ray Computed, Chin anatomy & histology, Mandibular Nerve anatomy & histology
- Abstract
The presence of accessory foramina and canals in the mandible is frequently overlooked in clinical procedures. It is important to note that these anatomical variations may only be pre-surgically detected on imaging exams, and such detection may directly influence therapeutic success. We describe a previously unreported case of accessory mental foramen located in the lingual cortical bone of the mandible.
- Published
- 2010
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40. Precursors to femicide: Guatemalan women in a vortex of violence.
- Author
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Carey D Jr and Torres MG
- Subjects
- Gender Identity, Guatemala ethnology, History, 20th Century, History, 21st Century, Social Conditions economics, Social Conditions history, Social Conditions legislation & jurisprudence, Women education, Women history, Women psychology, Cultural Characteristics history, Political Systems history, Violence economics, Violence ethnology, Violence history, Violence legislation & jurisprudence, Violence psychology, Women's Health ethnology, Women's Health history, Women's Rights economics, Women's Rights education, Women's Rights history, Women's Rights legislation & jurisprudence
- Abstract
Today women in Guatemala are killed at nearly the same rate as they were in the early 1980s when the civil war became genocidal. Yet the current femicide epidemic is less an aberration than a reflection of the way violence against women has become normalized in Guatemala. Used to re-inscribe patriarchy and sustain both dictatorships and democracies, gender-based violence morphed into femicide when peacetime governments became too weak to control extralegal and paramilitary powers. The naturalization of gender-based violence over the course of the twentieth century maintained and promoted the systemic impunity that undergirds femicide today. By accounting for the gendered and historical dimensions of the cultural practices of violence and impunity, we offer a re-conceptualization of the social relations that perpetuate femicide as an expression of post-war violence.
- Published
- 2010
41. Are immunoglobulin concentrations associated with the body composition of adolescents?
- Author
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Zúñiga-Torres MG, Martínez-Carrillo BE, Pardo-Morales RV, Wärnberg J, Marcos A, Benítez-Arciniega AD, and Valdés-Ramos R
- Subjects
- Adolescent, Body Mass Index, Child, Female, Humans, Male, Mexico, Waist-Hip Ratio, Body Composition, Immunoglobulin A blood, Immunoglobulin G blood, Immunoglobulin M blood
- Abstract
The aim of this study was to analyze the association between serum concentrations of immunoglobulins (Ig) A, G, and M and body composition of adolescents from Mexico. Informed consent was obtained from parents and assent was obtained from the adolescents for the evaluation of 125 adolescents from the Capital city of Toluca and the adjacent semiurban county of Lerma de Villada. Height, weight, waist, and hip circumference were measured by trained personnel. Body mass index and waist:hip ratio were calculated from these measurements, whereas body fat (BF) was calculated from tricipital and subscapular skinfolds and measured by bioelectrical impedance. Serum concentrations of Ig were determined by nephelometry. Data were analyzed by independent samples t test and Pearson correlations. Subjects were mainly females (71.2%), with a mean age of 16.8 years (+/-0.8). No differences were reported in all indicators by weight or BF between gender. Female participants had higher Ig concentrations than males (IgG t = 2.24, p = 0.027; IgA t = 2.05, p = 0.043; IgM t = 4.49, p < 0.001). Positive correlations were reported for IgA and IgM with tricipital skinfold (r = 0.192, p = 0.041; and r = 0.221, p = 0.018, respectively) and for total BF by bioimpedance (r = 0.243, p = 0.009). Ig concentrations do not seem to be affected by overweight, obesity, or excessive or central BF in adolescents.
- Published
- 2009
- Full Text
- View/download PDF
42. Hybrid lesion: central giant cell granuloma and benign fibro-osseous lesion.
- Author
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Crusoé-Rebello I, Torres MG, Burgos V, Oliveira C, Santos JN, Azevedo RA, and Campos PS
- Subjects
- Adult, Female, Fibroma, Ossifying complications, Granuloma, Giant Cell complications, Humans, Mandibular Neoplasms diagnostic imaging, Tomography, X-Ray Computed, Fibroma, Ossifying diagnostic imaging, Granuloma, Giant Cell diagnostic imaging, Mandibular Diseases diagnostic imaging
- Abstract
Hybrid lesions comprise elements of different pathologies in one lesion. Hybrid lesions comprising central giant cell granulomas (CGCG) with fibro-osseous components are rare, with only six maxillomandibular cases reported in the literature. We report a case of a hybrid lesion in a 38-year-old woman who presented with a swelling in the mandibular parasymphysis, on the left side. Panoramic and occlusal radiographs and CT showed a mixed lesion with expansion of the buccal cortical plate that pointed to the diagnosis of ossifying fibroma (OF). Complete excision of the lesion was performed, and the anatomopathological examination showed features of both CGCG and a fibro-osseous lesion. Clinical, imaging and histopathological features indicate a hybrid lesion of CGCG and OF. The patient remains asymptomatic after 30 months of follow-up.
- Published
- 2009
- Full Text
- View/download PDF
43. Arthritis induced by adjuvant in spontaneously hypertensive and normotensive rats: endogenous glucocorticoid effects on inflammatory response.
- Author
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Torres MG, Kwasniewski FH, Scaliante LG, Ishii-Iwamoto EL, Caparroz-Assef SM, Cuman RK, and Bersani-Amado CA
- Subjects
- Adrenalectomy, Animals, Arthritis, Experimental etiology, Body Weight, Edema chemically induced, Freund's Adjuvant, Hypertension genetics, Inflammation etiology, Male, Rats, Rats, Inbred SHR, Rats, Inbred WKY, Rats, Wistar, Reference Values, Arthritis, Experimental physiopathology, Edema physiopathology, Glucocorticoids physiology, Hypertension physiopathology, Inflammation physiopathology
- Abstract
The present study investigated arthritis induced by complete Freund adjuvant (AIA) in spontaneously hypertensive and normotensive rats (respectively, SHR and NTR rats). The inflammatory reaction was studied for 28 days by evaluating paw edema and secondary lesions found 10 days after complete Freund adjuvant (CFA) administration. The body weight of the animals and macroscopic alterations of several organs, including spleen, thymus, adrenal glands, and lymph nodes, were also analyzed. The results showed that the AIA manifestations were decreased in SHRs compared with NTRs. Moreover, this altered inflammatory response was not modified by surgical adrenalectomy.
- Published
- 2009
- Full Text
- View/download PDF
44. Surface complexation modeling of uranium(VI) sorbed onto zirconium oxophosphate versus temperature: thermodynamic and structural approaches.
- Author
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Almazan-Torres MG, Drot R, Mercier-Bion F, Catalette H, Den Auwer C, and Simoni E
- Abstract
This work presents an investigation of the interaction mechanisms between uranyl ions and a solid phosphate, the zirconium oxophosphate: Zr2O(PO4)2. Both thermodynamic and structural points of view are developed. Indeed, prior to any simulation of the retention data, it is necessary to precisely characterize the system under study in order to gain information at a molecular scale. First, the intrinsic surface properties of this synthetic compound have been investigated for different temperatures ranging from 25 to 90 degrees C. Mass and potentiometric titrations show that the surface site density remains constant between 25 and 90 degrees C, while the experimental point of zero charge slightly decreases from 4.8 to 4.5 with an increasing temperature. The potentiometric titration data are simulated, for each temperature, using the constant capacitance model and taking into account two surface sites ([TRIPLE BOND]ZrO and [TRIPLE BOND]PO) with a total surface site density equal to 7.0 sites nm(-2). For both reactive sites, the intrinsic protonation constants do not change with the temperature, while the deprotonation ones increase. These results led to the determination of the associated enthalpy and entropy changes according to the van't Hoff relation. Second, the speciation of U(VI) at the solid/solution interface has been studied using two complementary spectroscopic techniques probing the sorbed uranyl ions: time-resolved laser-induced fluorescence spectroscopy (TRLFS) and X-ray absorption spectroscopy (EXAFS). The substrate presents two different reactive surface sites against uranium retention, which are constituted by the oxygen atoms of the surface PO4 groups and the oxygen atoms linked to the zirconium atoms. Two inner-sphere complexes are thus present on the substrate, their relative proportion depending on the pH value of the suspension. The effects of the temperature (25-90 degrees C) on the surrounding uranium were checked using the TRLFS technique. The uranyl sorption constants onto the Zr2O(PO4)2 substrate were determined taking into account the structural investigation. The surface complexation modeling was performed using the constant capacitance model included in the FITEQLv4.0 code. The four adsorption edges obtained at 25, 50, 75, and 90 degrees C were simulated. The modeling of these experimental data was realized considering two surface complexes (([TRIPLE BOND]ZrOH)2UO(2+)2, ([TRIPLE BOND]PO)2UO2) according to the structural investigation. The constant value associated with the ZrO site does not change with the temperature, while the one corresponding to the PO site increases. Finally, the enthalpy and entropy changes associated with the uranyl sorption constants have been determined using the van't Hoff relation.
- Published
- 2008
- Full Text
- View/download PDF
45. [Phytoplankton from Tehuantepec River, Oaxaca, Mexico and some biogeographical relationships].
- Author
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Moreno-Ruiz JL, Tapia-García M, González-Macias Mdel C, and Figueroa-Torres MG
- Subjects
- Animals, Geography, Mexico, Rivers, Seasons, Biodiversity, Ecosystem, Environmental Monitoring, Phytoplankton classification
- Abstract
Phytoplankton species collected from the limnetic to euryhaline sections of Tehuantepec River were identified, classified and compared with regional information from Mexico and South America. We collected 15 samples every three months from July 1997 through August 1998 with a 20 microm net and a Van Dorn bottle. Indicator values and a code checklist are included. A total of 58 families, 121 genera, 273 species, one subspecies, 75 varieties, 13 forms and one morphotype were identified in the taxa Bacillariophyta (42.0 %), Chlorophyta (29.0 %), Cyanoprocaryota (18.0 %), Euglenophyta (5.0 %), Dinophyta (3.0 %), Cryptophyta (2.0 %) and Chrysophyta (1.0 %). The predominant families were Scenedesmaceae (24 species), Oocystaceae (22), Bacillariophyceae (21), Chaetocerotaceae (15) and Euglenaceae (14). Five families, eight genera, 72 species, 45 varieties and eight forms are first records for Mexico. The species Chroococcus turgidus, Microcystis flosaquae and Pseudanabaena limnetica (which produce massive blooms or red tides) are important in this river of moderate water quality.
- Published
- 2008
46. Acute immune and non-immune inflammatory response in spontaneously hypertensive rats and normotensive rats. Role of endogenous nitric oxide.
- Author
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Ferreira AA, Kwasniewski FH, Delani TC, Torres MG, Silva MA, Caparroz-Assef SM, Cuman RK, and Bersani-Amado CA
- Subjects
- Anaphylaxis chemically induced, Anaphylaxis immunology, Anaphylaxis metabolism, Animals, Capillary Permeability, Carrageenan, Cell Migration Assays, Leukocyte, Disease Models, Animal, Enzyme Inhibitors pharmacology, Exudates and Transudates cytology, Exudates and Transudates metabolism, Hypertension immunology, Leukocytes drug effects, Male, NG-Nitroarginine Methyl Ester pharmacology, Nitric Oxide Synthase antagonists & inhibitors, Nitric Oxide Synthase metabolism, Ovalbumin, Pleurisy chemically induced, Pleurisy etiology, Pleurisy immunology, Rats, Rats, Inbred SHR, Rats, Wistar, Anaphylaxis complications, Chemotaxis, Leukocyte drug effects, Hypertension metabolism, Leukocytes immunology, Nitric Oxide metabolism, Pleurisy metabolism
- Abstract
Unlabelled: The present study investigated the acute inflammatory response (increase in vascular permeability and leukocytes migration) in the pleura of spontaneously hypertensive rats (SHR) and normotensive rats (NTR), using two different stimulus: carrageenan and active anaphylaxis. In addition, the role of endogenous nitric oxide in these responses was investigated., Results: The inflammatory response induced by intrapleural carrageenan injection in SHR developed similarly to that in NTR. Treatment with L-NAME, reduced the intensity of this response in both groups of rats. The inflammatory response induced by active anaphylaxis in SHR and NTR was different. The increase in vascular permeability occurred later in the SHR compared to NTR. The number of leukocyte present in inflammatory exudates was increased at 4 h in both groups of rats. L-NAME treatment did not inhibit exudation at the intervals under analysis, however, reduced the number of mononuclear cells in the inflammatory exudate of SHR., Conclusion: The development of the inflammatory response in SHR differs from that in NTR, depending on the nature of the inflammatory stimulus. Endogenous NO plays a clear role in carrageenan-induced inflamma-tion, but not in immunologically mediated inflammation in the analyzed period.
- Published
- 2007
- Full Text
- View/download PDF
47. A case of acquired renal cystic disease (ACDK) with oncocytosis, a dominant nodule (oncocytoma), multiple adenomas and a microscopic papillary renal cell carcinoma associated with crescentic glomerulonephritis.
- Author
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Menéndez CL, Pobes A, Corte Torres MG, Fuente E, Merino AM, Corrales B, and Argüelles M
- Subjects
- Adenoma complications, Adenoma, Oxyphilic complications, Aged, Carcinoma, Papillary complications, Carcinoma, Renal Cell complications, Female, Glomerulonephritis complications, Humans, Kidney Diseases, Cystic complications, Kidney Neoplasms complications, Neoplasms, Multiple Primary, Nephrectomy, Adenoma pathology, Adenoma, Oxyphilic pathology, Carcinoma, Papillary pathology, Carcinoma, Renal Cell pathology, Glomerulonephritis pathology, Kidney Diseases, Cystic pathology, Kidney Neoplasms pathology, Oxyphil Cells pathology
- Published
- 2007
- Full Text
- View/download PDF
48. [Fulminant course of amniotic fluid embolism].
- Author
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Bermejo-Alvarez MA, Fervienza P, Corte-Torres MG, Cosío F, Jiménez-Gómez LJ, and Hevía A
- Subjects
- Adult, Fatal Outcome, Female, Humans, Pregnancy, Embolism, Amniotic Fluid diagnosis, Embolism, Amniotic Fluid therapy
- Abstract
Amniotic fluid embolism is an obstetric complication that can present during pregnancy or labor and is associated with high rates of morbidity and mortality. The incidence is low but the mortality rates for both mother and fetus are high. A 34-year-old woman in the 41st week of gestation was admitted for induction of labor. While still in the labor room, she complained of pruritus around the mouth and tongue. Tonic-clonic convulsions, hypotension, and loss of consciousness followed. Cardiopulmonary resuscitation maneuvers were started and an immediate cesarean section under general anesthesia was performed to deliver a live infant boy. The Apgar score at 5 minutes was 8. The mother was transferred for recovery to the intensive care unit (ICU), where rapid cardiocirculatory and pulmonary decline continued. After 2 episodes of electromechanical dissociation, exitus occurred 2 hours after ICU admission. The autopsy confirmed the diagnosis of amniotic fluid embolism. Keratin squames were found in the capillaries of both lungs and polymorphonuclear cells and proteinaceous material were observed in alveoli. Mechanical obstruction is not the only cause of amniotic fluid embolism. Circulating substances that affect myocardial contractility and coagulation are also implicated and the cause may even be an allergic reaction. The usual signs are acute respiratory failure, cardiovascular collapse, and occasionally convulsions and coagulopathy. Cardiac arrest occurs in 80% of the cases. Treatment is symptomatic to provide life-sustaining measures in response to the clinical picture as it develops.
- Published
- 2006
49. Dental follicles replantation after enucleation of an odontoma.
- Author
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Torres MG and Martins WD
- Subjects
- Child, Preschool, Female, Follow-Up Studies, Humans, Incisor diagnostic imaging, Radiography, Panoramic, Dental Sac surgery, Mandibular Neoplasms surgery, Odontoma surgery, Replantation
- Published
- 2004
- Full Text
- View/download PDF
50. Risk factors for Aujeszky's disease in pig herds and detection of field virus antibodies in fattening pigs in the state of Yucatan, Mexico.
- Author
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Rodríguez-Buenfil JC, Alvarez-Fleites M, Alzina-Lopez A, Arjona-Torres MG, Segura-Correa JC, and Villegas-Pérez S
- Subjects
- Animal Husbandry, Animals, Antibodies, Viral analysis, Case-Control Studies, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay veterinary, Female, Herpesvirus 1, Suid pathogenicity, Male, Mexico, Odds Ratio, Pseudorabies diagnosis, Pseudorabies immunology, Risk Factors, Serologic Tests, Swine, Vaccination veterinary, Herpesvirus 1, Suid immunology, Pseudorabies etiology
- Abstract
Two epidemiological studies were conducted from August 1997 to May 1998: a case-control study to identify herd level risk factors for antibodies to Aujeszky's disease virus (ADV) in sows in the state of Yucatan, Mexico and a cross-sectional study to determine the prevalence of antibodies against ADV in fattening pigs. In the case-control study, data on herd management and biosecurity were obtained from all the 27 ADV known field-virus-seropositive farms (cases) and 62 randomly selected seronegative farms (controls) by questionnaire. Breeding animals of these seropositive farms had received a gE-deletion vaccine. In the cross-sectional study, 26 farrow-to-finish farms of the 27 seropositive farms were used and blood samples taken from 60 fattening pigs per herd (15 pigs for each stage of production). Serum samples were analyzed by the screening-ELISA and gE-ELISA tests. In the case-control study, three of the 15 risk factors were significant. Odds ratios for distance to the nearest farm (< or = 2.5km), not sampling for the detection of ADV and herds with origin of breeding animals within the state were 9.5, 18.1 and 8.7. In the cross-sectional study, 11 (42.3%) of the 26 sampled farms were seropositive to vaccine antibodies. None of the piglets were positive to antibodies against field virus risk--suggesting that the strategy of vaccinating only the breeding animals reduced the ADV infection of the piglets.
- Published
- 2002
- Full Text
- View/download PDF
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