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Arthritis induced by adjuvant in spontaneously hypertensive and normotensive rats: endogenous glucocorticoid effects on inflammatory response.
- Source :
-
Inflammation [Inflammation] 2009 Feb; Vol. 32 (1), pp. 20-6. - Publication Year :
- 2009
-
Abstract
- The present study investigated arthritis induced by complete Freund adjuvant (AIA) in spontaneously hypertensive and normotensive rats (respectively, SHR and NTR rats). The inflammatory reaction was studied for 28 days by evaluating paw edema and secondary lesions found 10 days after complete Freund adjuvant (CFA) administration. The body weight of the animals and macroscopic alterations of several organs, including spleen, thymus, adrenal glands, and lymph nodes, were also analyzed. The results showed that the AIA manifestations were decreased in SHRs compared with NTRs. Moreover, this altered inflammatory response was not modified by surgical adrenalectomy.
- Subjects :
- Adrenalectomy
Animals
Arthritis, Experimental etiology
Body Weight
Edema chemically induced
Freund's Adjuvant
Hypertension genetics
Inflammation etiology
Male
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Rats, Wistar
Reference Values
Arthritis, Experimental physiopathology
Edema physiopathology
Glucocorticoids physiology
Hypertension physiopathology
Inflammation physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0360-3997
- Volume :
- 32
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 19030974
- Full Text :
- https://doi.org/10.1007/s10753-008-9098-7