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1. Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study.

Author: Georgiadis, Foivos, Larivière, Sara, Glahn, David, Hong, L, Kochunov, Peter, Mowry, Bryan, Loughland, Carmel, Pantelis, Christos, Henskens, Frans, Green, Melissa, Cairns, Murray, Michie, Patricia, Rasser, Paul, Catts, Stanley, Tooney, Paul, Scott, Rodney, Schall, Ulrich, Carr, Vaughan, Quidé, Yann, Krug, Axel, Stein, Frederike, Nenadić, Igor, Brosch, Katharina, Kircher, Tilo, Gur, Raquel, Gur, Ruben, Satterthwaite, Theodore, Karuk, Andriana, Pomarol-Clotet, Edith, Radua, Joaquim, Fuentes-Claramonte, Paola, Salvador, Raymond, Spalletta, Gianfranco, Voineskos, Aristotle, Sim, Kang, Crespo-Facorro, Benedicto, Tordesillas Gutiérrez, Diana, Ehrlich, Stefan, Crossley, Nicolas, Grotegerd, Dominik, Repple, Jonathan, Lencer, Rebekka, Dannlowski, Udo, Calhoun, Vince, Rootes-Murdy, Kelly, Demro, Caroline, Ramsay, Ian, Sponheim, Scott, Schmidt, Andre, Borgwardt, Stefan, Tomyshev, Alexander, Lebedeva, Irina, Höschl, Cyril, Spaniel, Filip, Preda, Adrian, Nguyen, Dana, Uhlmann, Anne, Stein, Dan, Howells, Fleur, Temmingh, Henk, Diaz Zuluaga, Ana, López Jaramillo, Carlos, Iasevoli, Felice, Ji, Ellen, Homan, Stephanie, Omlor, Wolfgang, Homan, Philipp, Kaiser, Stefan, Seifritz, Erich, Misic, Bratislav, Valk, Sofie, Thompson, Paul, Van Erp, Theodorus, Turner, Jessica, Bernhardt, Boris, and Kirschner, Matthias
Subjects: Humans, Schizophrenia, Connectome, Adult, Female, Male, Magnetic Resonance Imaging, Cerebral Cortex, Nerve Net, Brain, Middle Aged, Neural Pathways, Young Adult
Abstract: Schizophrenia is a prototypical network disorder with widespread brain-morphological alterations, yet it remains unclear whether these distributed alterations robustly reflect the underlying network layout. We tested whether large-scale structural alterations in schizophrenia relate to normative structural and functional connectome architecture, and systematically evaluated robustness and generalizability of these network-level alterations. Leveraging anatomical MRI scans from 2439 adults with schizophrenia and 2867 healthy controls from 26 ENIGMA sites and normative data from the Human Connectome Project (n = 207), we evaluated structural alterations of schizophrenia against two network susceptibility models: (i) hub vulnerability, which examines associations between regional network centrality and magnitude of disease-related alterations; (ii) epicenter mapping, which identifies regions whose typical connectivity profile most closely resembles the disease-related morphological alterations. To assess generalizability and specificity, we contextualized the influence of site, disease stages, and individual clinical factors and compared network associations of schizophrenia with that found in affective disorders. Our findings show schizophrenia-related cortical thinning is spatially associated with functional and structural hubs, suggesting that highly interconnected regions are more vulnerable to morphological alterations. Predominantly temporo-paralimbic and frontal regions emerged as epicenters with connectivity profiles linked to schizophrenias alteration patterns. Findings were robust across sites, disease stages, and related to individual symptoms. Moreover, transdiagnostic comparisons revealed overlapping epicenters in schizophrenia and bipolar, but not major depressive disorder, suggestive of a pathophysiological continuity within the schizophrenia-bipolar-spectrum. In sum, cortical alterations over the course of schizophrenia robustly follow brain network architecture, emphasizing marked hub susceptibility and temporo-frontal epicenters at both the level of the group and the individual. Subtle variations of epicenters across disease stages suggest interacting pathological processes, while associations with patient-specific symptoms support additional inter-individual variability of hub vulnerability and epicenters in schizophrenia. Our work outlines potential pathways to better understand macroscale structural alterations, and inter- individual variability in schizophrenia.
Published: 2024

2. Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

Author: García-Marín, Luis M., Campos, Adrian I., Diaz-Torres, Santiago, Rabinowitz, Jill A., Ceja, Zuriel, Mitchell, Brittany L., Grasby, Katrina L., Thorp, Jackson G., Agartz, Ingrid, Alhusaini, Saud, Ames, David, Amouyel, Philippe, Andreassen, Ole A., Arfanakis, Konstantinos, Arias-Vasquez, Alejandro, Armstrong, Nicola J., Athanasiu, Lavinia, Bastin, Mark E., Beiser, Alexa S., Bennett, David A., Bis, Joshua C., Boks, Marco P. M., Boomsma, Dorret I., Brodaty, Henry, Brouwer, Rachel M., Buitelaar, Jan K., Burkhardt, Ralph, Cahn, Wiepke, Calhoun, Vince D., Carmichael, Owen T., Chakravarty, Mallar, Chen, Qiang, Ching, Christopher R. K., Cichon, Sven, Crespo-Facorro, Benedicto, Crivello, Fabrice, Dale, Anders M., Smith, George Davey, de Geus, Eco J. C., De Jager, Philip L., de Zubicaray, Greig I., Debette, Stéphanie, DeCarli, Charles, Depondt, Chantal, Desrivières, Sylvane, Djurovic, Srdjan, Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fernández, Guillén, Filippi, Irina, Fisher, Simon E., Fleischman, Debra A., Fletcher, Evan, Fornage, Myriam, Forstner, Andreas J., Francks, Clyde, Franke, Barbara, Ge, Tian, Goldman, Aaron L., Grabe, Hans J., Green, Robert C., Grimm, Oliver, Groenewold, Nynke A., Gruber, Oliver, Gudnason, Vilmundur, Håberg, Asta K., Haukvik, Unn K., Heinz, Andreas, Hibar, Derrek P., Hilal, Saima, Himali, Jayandra J., Ho, Beng-Choon, Hoehn, David F., Hoekstra, Pieter J., Hofer, Edith, Hoffmann, Wolfgang, Holmes, Avram J., Homuth, Georg, Hosten, Norbert, Ikram, M. Kamran, Ipser, Jonathan C., Jack Jr, Clifford R., Jahanshad, Neda, Jönsson, Erik G., Kahn, Rene S., Kanai, Ryota, Klein, Marieke, Knol, Maria J., Launer, Lenore J., Lawrie, Stephen M., Hellard, Stephanie Le, Lee, Phil H., Lemaître, Hervé, Li, Shuo, Liewald, David C. M., Lin, Honghuang, Longstreth, Jr, W. T., Lopez, Oscar L., Luciano, Michelle, Maillard, Pauline, Marquand, Andre F., Martin, Nicholas G., Martinot, Jean-Luc, Mather, Karen A., Mattay, Venkata S., McMahon, Katie L., Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Mirza-Schreiber, Nazanin, Milaneschi, Yuri, Mosley, Thomas H., Mühleisen, Thomas W., Müller-Myhsok, Bertram, Maniega, Susana Muñoz, Nauck, Matthias, Nho, Kwangsik, Niessen, Wiro J., Nöthen, Markus M., Nyquist, Paul A., Oosterlaan, Jaap, Pandolfo, Massimo, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda W. J. H., Pike, G. Bruce, Psaty, Bruce M., Pütz, Benno, Reppermund, Simone, Rietschel, Marcella D., Risacher, Shannon L., Romanczuk-Seiferth, Nina, Romero-Garcia, Rafael, Roshchupkin, Gennady V., Rotter, Jerome I., Sachdev, Perminder S., Sämann, Philipp G., Saremi, Arvin, Sargurupremraj, Muralidharan, Saykin, Andrew J., Schmaal, Lianne, Schmidt, Helena, Schmidt, Reinhold, Schofield, Peter R., Scholz, Markus, Schumann, Gunter, Schwarz, Emanuel, Shen, Li, Shin, Jean, Sisodiya, Sanjay M., Smith, Albert V., Smoller, Jordan W., Soininen, Hilkka S., Steen, Vidar M., Stein, Dan J., Stein, Jason L., Thomopoulos, Sophia I., Toga, Arthur W., Tordesillas-Gutiérrez, Diana, Trollor, Julian N., Valdes-Hernandez, Maria C., van ′t Ent, Dennis, van Bokhoven, Hans, van der Meer, Dennis, van der Wee, Nic J. A., Vázquez-Bourgon, Javier, Veltman, Dick J., Vernooij, Meike W., Villringer, Arno, Vinke, Louis N., Völzke, Henry, Walter, Henrik, Wardlaw, Joanna M., Weinberger, Daniel R., Weiner, Michael W., Wen, Wei, Westlye, Lars T., Westman, Eric, White, Tonya, Witte, A. Veronica, Wolf, Christiane, Yang, Jingyun, Zwiers, Marcel P., Ikram, M. Arfan, Seshadri, Sudha, Thompson, Paul M., Satizabal, Claudia L., Medland, Sarah E., and Rentería, Miguel E.
Published: 2024
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3. In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis

Author: Barth, Claudia, Kelly, Sinead, Nerland, Stener, Jahanshad, Neda, Alloza, Clara, Ambrogi, Sonia, Andreassen, Ole A, Andreou, Dimitrios, Arango, Celso, Baeza, Inmaculada, Banaj, Nerisa, Bearden, Carrie E, Berk, Michael, Bohman, Hannes, Castro-Fornieles, Josefina, Chye, Yann, Crespo-Facorro, Benedicto, de la Serna, Elena, Díaz-Caneja, Covadonga M, Gurholt, Tiril P, Hegarty, Catherine E, James, Anthony, Janssen, Joost, Johannessen, Cecilie, Jönsson, Erik G, Karlsgodt, Katherine H, Kochunov, Peter, Lois, Noemi G, Lundberg, Mathias, Myhre, Anne M, Pascual-Diaz, Saül, Piras, Fabrizio, Smelror, Runar E, Spalletta, Gianfranco, Stokkan, Therese S, Sugranyes, Gisela, Suo, Chao, Thomopoulos, Sophia I, Tordesillas-Gutiérrez, Diana, Vecchio, Daniela, Wedervang-Resell, Kirsten, Wortinger, Laura A, Thompson, Paul M, and Agartz, Ingrid
Subjects: Brain Disorders, Serious Mental Illness, Pediatric, Biomedical Imaging, Clinical Research, Neurosciences, Mental Health, Schizophrenia, Mental health, Good Health and Well Being, Female, Humans, Male, Adolescent, White Matter, Diffusion Tensor Imaging, Brain, Psychotic Disorders, Anisotropy, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract: Emerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset
Published: 2023

4. Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium.

Author: Constantinides, Constantinos, Han, Laura KM, Alloza, Clara, Antonucci, Linda Antonella, Arango, Celso, Ayesa-Arriola, Rosa, Banaj, Nerisa, Bertolino, Alessandro, Borgwardt, Stefan, Bruggemann, Jason, Bustillo, Juan, Bykhovski, Oleg, Calhoun, Vince, Carr, Vaughan, Catts, Stanley, Chung, Young-Chul, Crespo-Facorro, Benedicto, Díaz-Caneja, Covadonga M, Donohoe, Gary, Plessis, Stefan Du, Edmond, Jesse, Ehrlich, Stefan, Emsley, Robin, Eyler, Lisa T, Fuentes-Claramonte, Paola, Georgiadis, Foivos, Green, Melissa, Guerrero-Pedraza, Amalia, Ha, Minji, Hahn, Tim, Henskens, Frans A, Holleran, Laurena, Homan, Stephanie, Homan, Philipp, Jahanshad, Neda, Janssen, Joost, Ji, Ellen, Kaiser, Stefan, Kaleda, Vasily, Kim, Minah, Kim, Woo-Sung, Kirschner, Matthias, Kochunov, Peter, Kwak, Yoo Bin, Kwon, Jun Soo, Lebedeva, Irina, Liu, Jingyu, Mitchie, Patricia, Michielse, Stijn, Mothersill, David, Mowry, Bryan, de la Foz, Víctor Ortiz-García, Pantelis, Christos, Pergola, Giulio, Piras, Fabrizio, Pomarol-Clotet, Edith, Preda, Adrian, Quidé, Yann, Rasser, Paul E, Rootes-Murdy, Kelly, Salvador, Raymond, Sangiuliano, Marina, Sarró, Salvador, Schall, Ulrich, Schmidt, André, Scott, Rodney J, Selvaggi, Pierluigi, Sim, Kang, Skoch, Antonin, Spalletta, Gianfranco, Spaniel, Filip, Thomopoulos, Sophia I, Tomecek, David, Tomyshev, Alexander S, Tordesillas-Gutiérrez, Diana, van Amelsvoort, Therese, Vázquez-Bourgon, Javier, Vecchio, Daniela, Voineskos, Aristotle, Weickert, Cynthia S, Weickert, Thomas, Thompson, Paul M, Schmaal, Lianne, van Erp, Theo GM, Turner, Jessica, Cole, James H, ENIGMA Schizophrenia Consortium, Dima, Danai, and Walton, Esther
Subjects: ENIGMA Schizophrenia Consortium, Brain, Humans, Magnetic Resonance Imaging, Prospective Studies, Schizophrenia, Aging, Adolescent, Adult, Aged, Middle Aged, Female, Male, Young Adult, Mental Health, Serious Mental Illness, Brain Disorders, Neurosciences, Biomedical Imaging, Clinical Research, Behavioral and Social Science, Neurological, Mental health, Good Health and Well Being, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract: Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study conducted by the ENIGMA Schizophrenia Working Group. The study included data from 26 cohorts worldwide, with a total of 2803 SZ patients (mean age 34.2 years; range 18-72 years; 67% male) and 2598 healthy controls (mean age 33.8 years, range 18-73 years, 55% male). Brain-predicted age was individually estimated using a model trained on independent data based on 68 measures of cortical thickness and surface area, 7 subcortical volumes, lateral ventricular volumes and total intracranial volume, all derived from T1-weighted brain magnetic resonance imaging (MRI) scans. Deviations from a healthy brain ageing trajectory were assessed by the difference between brain-predicted age and chronological age (brain-predicted age difference [brain-PAD]). On average, SZ patients showed a higher brain-PAD of +3.55 years (95% CI: 2.91, 4.19; I2 = 57.53%) compared to controls, after adjusting for age, sex and site (Cohen's d = 0.48). Among SZ patients, brain-PAD was not associated with specific clinical characteristics (age of onset, duration of illness, symptom severity, or antipsychotic use and dose). This large-scale collaborative study suggests advanced structural brain ageing in SZ. Longitudinal studies of SZ and a range of mental and somatic health outcomes will help to further evaluate the clinical implications of increased brain-PAD and its ability to be influenced by interventions.
Published: 2023

5. Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study

Author: Si, Shuqing, Bi, Anbreen, Yu, Zhaoying, See, Cheryl, Kelly, Sinead, Ambrogi, Sonia, Arango, Celso, Baeza, Inmaculada, Banaj, Nerisa, Berk, Michael, Castro-Fornieles, Josefina, Crespo-Facorro, Benedicto, Crouse, Jacob J., Díaz-Caneja, Covadonga M., Fett, Anne-Kathrin, Fortea, Adriana, Frangou, Sophia, Goldstein, Benjamin I., Hickie, Ian B., Janssen, Joost, Kennedy, Kody G., Krabbendam, Lydia, Kyriakopoulos, Marinos, MacIntosh, Bradley J., Morgado, Pedro, Nerland, Stener, Pascual-Diaz, Saül, Picó-Pérez, Maria, Piras, Fabrizio, Rund, Bjørn Rishovd, de la Serna, Elena, Spalletta, Gianfranco, Sugranyes, Gisela, Suo, Chao, Tordesillas-Gutiérrez, Diana, Vecchio, Daniela, Radua, Joaquim, McGuire, Philip, Thomopoulos, Sophia I., Jahanshad, Neda, Thompson, Paul M., Barth, Claudia, Agartz, Ingrid, James, Anthony, and Kempton, Matthew J.
Published: 2024
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6. Obesity and brain structure in schizophrenia – ENIGMA study in 3021 individuals

Author: McWhinney, Sean R, Brosch, Katharina, Calhoun, Vince D, Crespo-Facorro, Benedicto, Crossley, Nicolas A, Dannlowski, Udo, Dickie, Erin, Dietze, Lorielle MF, Donohoe, Gary, Du Plessis, Stefan, Ehrlich, Stefan, Emsley, Robin, Furstova, Petra, Glahn, David C, Gonzalez- Valderrama, Alfonso, Grotegerd, Dominik, Holleran, Laurena, Kircher, Tilo TJ, Knytl, Pavel, Kolenic, Marian, Lencer, Rebekka, Nenadić, Igor, Opel, Nils, Pfarr, Julia-Katharina, Rodrigue, Amanda L, Rootes-Murdy, Kelly, Ross, Alex J, Sim, Kang, Škoch, Antonín, Spaniel, Filip, Stein, Frederike, Švancer, Patrik, Tordesillas-Gutiérrez, Diana, Undurraga, Juan, Vázquez-Bourgon, Javier, Voineskos, Aristotle, Walton, Esther, Weickert, Thomas W, Weickert, Cynthia Shannon, Thompson, Paul M, van Erp, Theo GM, Turner, Jessica A, and Hajek, Tomas
Subjects: Biomedical Imaging, Obesity, Neurosciences, Serious Mental Illness, Mental Health, Schizophrenia, Nutrition, Clinical Research, Brain Disorders, 2.1 Biological and endogenous factors, Aetiology, Mental health, Humans, Depressive Disorder, Major, Brain, Magnetic Resonance Imaging, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract: Schizophrenia is frequently associated with obesity, which is linked with neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto the brain changes in schizophrenia. We obtained MRI-derived brain cortical and subcortical measures and body mass index (BMI) from 1260 individuals with schizophrenia and 1761 controls from 12 independent research sites within the ENIGMA-Schizophrenia Working Group. We jointly modeled the statistical effects of schizophrenia and BMI using mixed effects. BMI was additively associated with structure of many of the same brain regions as schizophrenia, but the cortical and subcortical alterations in schizophrenia were more widespread and pronounced. Both BMI and schizophrenia were primarily associated with changes in cortical thickness, with fewer correlates in surface area. While, BMI was negatively associated with cortical thickness, the significant associations between BMI and surface area or subcortical volumes were positive. Lastly, the brain correlates of obesity were replicated among large studies and closely resembled neurostructural changes in major depressive disorders. We confirmed widespread associations between BMI and brain structure in individuals with schizophrenia. People with both obesity and schizophrenia showed more pronounced brain alterations than people with only one of these conditions. Obesity appears to be a relevant factor which could account for heterogeneity of brain imaging findings and for differences in brain imaging outcomes among people with schizophrenia.
Published: 2022

7. Genetic variants associated with longitudinal changes in brain structure across the lifespan

Author: Brouwer, Rachel M, Klein, Marieke, Grasby, Katrina L, Schnack, Hugo G, Jahanshad, Neda, Teeuw, Jalmar, Thomopoulos, Sophia I, Sprooten, Emma, Franz, Carol E, Gogtay, Nitin, Kremen, William S, Panizzon, Matthew S, Olde Loohuis, Loes M, Whelan, Christopher D, Aghajani, Moji, Alloza, Clara, Alnæs, Dag, Artiges, Eric, Ayesa-Arriola, Rosa, Barker, Gareth J, Bastin, Mark E, Blok, Elisabet, Bøen, Erlend, Breukelaar, Isabella A, Bright, Joanna K, Buimer, Elizabeth EL, Bülow, Robin, Cannon, Dara M, Ciufolini, Simone, Crossley, Nicolas A, Damatac, Christienne G, Dazzan, Paola, de Mol, Casper L, de Zwarte, Sonja MC, Desrivières, Sylvane, Díaz-Caneja, Covadonga M, Doan, Nhat Trung, Dohm, Katharina, Fröhner, Juliane H, Goltermann, Janik, Grigis, Antoine, Grotegerd, Dominik, Han, Laura KM, Harris, Mathew A, Hartman, Catharina A, Heany, Sarah J, Heindel, Walter, Heslenfeld, Dirk J, Hohmann, Sarah, Ittermann, Bernd, Jansen, Philip R, Janssen, Joost, Jia, Tianye, Jiang, Jiyang, Jockwitz, Christiane, Karali, Temmuz, Keeser, Daniel, Koevoets, Martijn GJC, Lenroot, Rhoshel K, Malchow, Berend, Mandl, René CW, Medel, Vicente, Meinert, Susanne, Morgan, Catherine A, Mühleisen, Thomas W, Nabulsi, Leila, Opel, Nils, de la Foz, Víctor Ortiz-García, Overs, Bronwyn J, Paillère Martinot, Marie-Laure, Redlich, Ronny, Marques, Tiago Reis, Repple, Jonathan, Roberts, Gloria, Roshchupkin, Gennady V, Setiaman, Nikita, Shumskaya, Elena, Stein, Frederike, Sudre, Gustavo, Takahashi, Shun, Thalamuthu, Anbupalam, Tordesillas-Gutiérrez, Diana, van der Lugt, Aad, van Haren, Neeltje EM, Wardlaw, Joanna M, Wen, Wei, Westeneng, Henk-Jan, Wittfeld, Katharina, Zhu, Alyssa H, Zugman, Andre, Armstrong, Nicola J, Bonfiglio, Gaia, Bralten, Janita, Dalvie, Shareefa, Davies, Gail, Di Forti, Marta, Ding, Linda, Donohoe, Gary, Forstner, Andreas J, and Gonzalez-Peñas, Javier
Subjects: Biological Psychology, Psychology, Genetics, Biomedical Imaging, Mental Health, Biotechnology, Human Genome, Prevention, Aging, Brain Disorders, Neurosciences, 2.1 Biological and endogenous factors, Aetiology, Mental health, Neurological, Brain, Genome-Wide Association Study, Humans, Longevity, Magnetic Resonance Imaging, IMAGEN Consortium, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract: Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.
Published: 2022

8. Effects of copy number variations on brain structure and risk for psychiatric illness: Large‐scale studies from the ENIGMA working groups on CNVs

Author: Sønderby, Ida E, Ching, Christopher RK, Thomopoulos, Sophia I, van der Meer, Dennis, Sun, Daqiang, Villalon‐Reina, Julio E, Agartz, Ingrid, Amunts, Katrin, Arango, Celso, Armstrong, Nicola J, Ayesa‐Arriola, Rosa, Bakker, Geor, Bassett, Anne S, Boomsma, Dorret I, Bülow, Robin, Butcher, Nancy J, Calhoun, Vince D, Caspers, Svenja, Chow, Eva WC, Cichon, Sven, Ciufolini, Simone, Craig, Michael C, Crespo‐Facorro, Benedicto, Cunningham, Adam C, Dale, Anders M, Dazzan, Paola, de Zubicaray, Greig I, Djurovic, Srdjan, Doherty, Joanne L, Donohoe, Gary, Draganski, Bogdan, Durdle, Courtney A, Ehrlich, Stefan, Emanuel, Beverly S, Espeseth, Thomas, Fisher, Simon E, Ge, Tian, Glahn, David C, Grabe, Hans J, Gur, Raquel E, Gutman, Boris A, Haavik, Jan, Håberg, Asta K, Hansen, Laura A, Hashimoto, Ryota, Hibar, Derrek P, Holmes, Avram J, Hottenga, Jouke‐Jan, Pol, Hilleke E Hulshoff, Jalbrzikowski, Maria, Knowles, Emma EM, Kushan, Leila, Linden, David EJ, Liu, Jingyu, Lundervold, Astri J, Martin‐Brevet, Sandra, Martínez, Kenia, Mather, Karen A, Mathias, Samuel R, McDonald‐McGinn, Donna M, McRae, Allan F, Medland, Sarah E, Moberget, Torgeir, Modenato, Claudia, Sánchez, Jennifer Monereo, Moreau, Clara A, Mühleisen, Thomas W, Paus, Tomas, Pausova, Zdenka, Prieto, Carlos, Ragothaman, Anjanibhargavi, Reinbold, Céline S, Marques, Tiago Reis, Repetto, Gabriela M, Reymond, Alexandre, Roalf, David R, Rodriguez‐Herreros, Borja, Rucker, James J, Sachdev, Perminder S, Schmitt, James E, Schofield, Peter R, Silva, Ana I, Stefansson, Hreinn, Stein, Dan J, Tamnes, Christian K, Tordesillas‐Gutiérrez, Diana, Ulfarsson, Magnus O, Vajdi, Ariana, van 't Ent, Dennis, van den Bree, Marianne BM, Vassos, Evangelos, Vázquez‐Bourgon, Javier, Vila‐Rodriguez, Fidel, Walters, G Bragi, Wen, Wei, Westlye, Lars T, Wittfeld, Katharina, Zackai, Elaine H, Stefánsson, Kári, and Jacquemont, Sebastien
Subjects: Biological Psychology, Biomedical and Clinical Sciences, Psychology, Mental Health, Clinical Research, Pediatric, Genetics, Basic Behavioral and Social Science, Human Genome, Prevention, Brain Disorders, Behavioral and Social Science, Neurosciences, Aetiology, 2.1 Biological and endogenous factors, Mental health, Neurological, Brain, DNA Copy Number Variations, Humans, Magnetic Resonance Imaging, Mental Disorders, Multicenter Studies as Topic, Neurodevelopmental Disorders, Neuroimaging, brain structural imaging, copy number variant, diffusion tensor imaging, evolution, genetics-first approach, neurodevelopmental disorders, psychiatric disorders, ENIGMA-CNV Working Group, ENIGMA 22q11.2 Deletion Syndrome Working Group, Cognitive Sciences, Experimental Psychology, Biological psychology, Cognitive and computational psychology
Abstract: The Enhancing NeuroImaging Genetics through Meta-Analysis copy number variant (ENIGMA-CNV) and 22q11.2 Deletion Syndrome Working Groups (22q-ENIGMA WGs) were created to gain insight into the involvement of genetic factors in human brain development and related cognitive, psychiatric and behavioral manifestations. To that end, the ENIGMA-CNV WG has collated CNV and magnetic resonance imaging (MRI) data from ~49,000 individuals across 38 global research sites, yielding one of the largest studies to date on the effects of CNVs on brain structures in the general population. The 22q-ENIGMA WG includes 12 international research centers that assessed over 533 individuals with a confirmed 22q11.2 deletion syndrome, 40 with 22q11.2 duplications, and 333 typically developing controls, creating the largest-ever 22q11.2 CNV neuroimaging data set. In this review, we outline the ENIGMA infrastructure and procedures for multi-site analysis of CNVs and MRI data. So far, ENIGMA has identified effects of the 22q11.2, 16p11.2 distal, 15q11.2, and 1q21.1 distal CNVs on subcortical and cortical brain structures. Each CNV is associated with differences in cognitive, neurodevelopmental and neuropsychiatric traits, with characteristic patterns of brain structural abnormalities. Evidence of gene-dosage effects on distinct brain regions also emerged, providing further insight into genotype-phenotype relationships. Taken together, these results offer a more comprehensive picture of molecular mechanisms involved in typical and atypical brain development. This "genotype-first" approach also contributes to our understanding of the etiopathogenesis of brain disorders. Finally, we outline future directions to better understand effects of CNVs on brain structure and behavior.
Published: 2022

9. A meta‐analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium

Author: Gutman, Boris A, Erp, Theo GM, Alpert, Kathryn, Ching, Christopher RK, Isaev, Dmitry, Ragothaman, Anjani, Jahanshad, Neda, Saremi, Arvin, Zavaliangos‐Petropulu, Artemis, Glahn, David C, Shen, Li, Cong, Shan, Alnæs, Dag, Andreassen, Ole Andreas, Doan, Nhat Trung, Westlye, Lars T, Kochunov, Peter, Satterthwaite, Theodore D, Wolf, Daniel H, Huang, Alexander J, Kessler, Charles, Weideman, Andrea, Nguyen, Dana, Mueller, Bryon A, Faziola, Lawrence, Potkin, Steven G, Preda, Adrian, Mathalon, Daniel H, Bustillo, Juan, Calhoun, Vince, Ford, Judith M, Walton, Esther, Ehrlich, Stefan, Ducci, Giuseppe, Banaj, Nerisa, Piras, Fabrizio, Piras, Federica, Spalletta, Gianfranco, Canales‐Rodríguez, Erick J, Fuentes‐Claramonte, Paola, Pomarol‐Clotet, Edith, Radua, Joaquim, Salvador, Raymond, Sarró, Salvador, Dickie, Erin W, Voineskos, Aristotle, Tordesillas‐Gutiérrez, Diana, Crespo‐Facorro, Benedicto, Setién‐Suero, Esther, Son, Jacqueline Mayoral, Borgwardt, Stefan, Schönborn‐Harrisberger, Fabienne, Morris, Derek, Donohoe, Gary, Holleran, Laurena, Cannon, Dara, McDonald, Colm, Corvin, Aiden, Gill, Michael, Filho, Geraldo Busatto, Rosa, Pedro GP, Serpa, Mauricio H, Zanetti, Marcus V, Lebedeva, Irina, Kaleda, Vasily, Tomyshev, Alexander, Crow, Tim, James, Anthony, Cervenka, Simon, Sellgren, Carl M, Fatouros‐Bergman, Helena, Agartz, Ingrid, Howells, Fleur, Stein, Dan J, Temmingh, Henk, Uhlmann, Anne, Zubicaray, Greig I, McMahon, Katie L, Wright, Margie, Cobia, Derin, Csernansky, John G, Thompson, Paul M, Turner, Jessica A, and Wang, Lei
Subjects: Brain Disorders, Mental Health, Neurosciences, Schizophrenia, Mental health, Good Health and Well Being, Amygdala, Corpus Striatum, Hippocampus, Humans, Multicenter Studies as Topic, Neuroimaging, Thalamus, schizophrenia, structure, subcortical shape, Cognitive Sciences, Experimental Psychology
Abstract: Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta-analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more-convex-than-concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta-analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia.
Published: 2022

10. Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers

Author: Boen, Rune, Kaufmann, Tobias, van der Meer, Dennis, Frei, Oleksandr, Agartz, Ingrid, Ames, David, Andersson, Micael, Armstrong, Nicola J., Artiges, Eric, Atkins, Joshua R., Bauer, Jochen, Benedetti, Francesco, Boomsma, Dorret I., Brodaty, Henry, Brosch, Katharina, Buckner, Randy L., Cairns, Murray J., Calhoun, Vince, Caspers, Svenja, Cichon, Sven, Corvin, Aiden P., Crespo-Facorro, Benedicto, Dannlowski, Udo, David, Friederike S., de Geus, Eco J.C., de Zubicaray, Greig I., Desrivières, Sylvane, Doherty, Joanne L., Donohoe, Gary, Ehrlich, Stefan, Eising, Else, Espeseth, Thomas, Fisher, Simon E., Forstner, Andreas J., Fortaner-Uyà, Lidia, Frouin, Vincent, Fukunaga, Masaki, Ge, Tian, Glahn, David C., Goltermann, Janik, Grabe, Hans J., Green, Melissa J., Groenewold, Nynke A., Grotegerd, Dominik, Grøntvedt, Gøril Rolfseng, Hahn, Tim, Hashimoto, Ryota, Hehir-Kwa, Jayne Y., Henskens, Frans A., Holmes, Avram J., Håberg, Asta K., Haavik, Jan, Jacquemont, Sebastien, Jansen, Andreas, Jockwitz, Christiane, Jönsson, Erik G., Kikuchi, Masataka, Kircher, Tilo, Kumar, Kuldeep, Le Hellard, Stephanie, Leu, Costin, Linden, David E., Liu, Jingyu, Loughnan, Robert, Mather, Karen A., McMahon, Katie L., McRae, Allan F., Medland, Sarah E., Meinert, Susanne, Moreau, Clara A., Morris, Derek W., Mowry, Bryan J., Mühleisen, Thomas W., Nenadić, Igor, Nöthen, Markus M., Nyberg, Lars, Ophoff, Roel A., Owen, Michael J., Pantelis, Christos, Paolini, Marco, Paus, Tomas, Pausova, Zdenka, Persson, Karin, Quidé, Yann, Marques, Tiago Reis, Sachdev, Perminder S., Sando, Sigrid B., Schall, Ulrich, Scott, Rodney J., Selbæk, Geir, Shumskaya, Elena, Silva, Ana I., Sisodiya, Sanjay M., Stein, Frederike, Stein, Dan J., Straube, Benjamin, Streit, Fabian, Strike, Lachlan T., Teumer, Alexander, Teutenberg, Lea, Thalamuthu, Anbupalam, Tooney, Paul A., Tordesillas-Gutierrez, Diana, Trollor, Julian N., van ’t Ent, Dennis, van den Bree, Marianne B.M., van Haren, Neeltje E.M., Vázquez-Bourgon, Javier, Völzke, Henry, Wen, Wei, Wittfeld, Katharina, Ching, Christopher R.K., Westlye, Lars T., Thompson, Paul M., Bearden, Carrie E., Selmer, Kaja K., Alnæs, Dag, Andreassen, Ole A., and Sønderby, Ida E.
Published: 2024
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11. Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Author: Jia, Tianye, Chu, Congying, Liu, Yun, van Dongen, Jenny, Papastergios, Evangelos, Armstrong, Nicola J, Bastin, Mark E, Carrillo-Roa, Tania, den Braber, Anouk, Harris, Mathew, Jansen, Rick, Liu, Jingyu, Luciano, Michelle, Ori, Anil PS, Roiz Santiañez, Roberto, Ruggeri, Barbara, Sarkisyan, Daniil, Shin, Jean, Sungeun, Kim, Tordesillas Gutiérrez, Diana, van’t Ent, Dennis, Ames, David, Artiges, Eric, Bakalkin, Georgy, Banaschewski, Tobias, Bokde, Arun LW, Brodaty, Henry, Bromberg, Uli, Brouwer, Rachel, Büchel, Christian, Burke Quinlan, Erin, Cahn, Wiepke, de Zubicaray, Greig I, Ehrlich, Stefan, Ekström, Tomas J, Flor, Herta, Fröhner, Juliane H, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Hoare, Jacqueline, Ittermann, Bernd, Jahanshad, Neda, Jiang, Jiyang, Kwok, John B, Martin, Nicholas G, Martinot, Jean-Luc, Mather, Karen A, McMahon, Katie L, McRae, Allan F, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Sämann, Philipp G, Schofield, Peter R, Smolka, Michael N, Stein, Dan J, Strike, Lachlan T, Teeuw, Jalmar, Thalamuthu, Anbupalam, Trollor, Julian, Walter, Henrik, Wardlaw, Joanna M, Wen, Wei, Whelan, Robert, Apostolova, Liana G, Binder, Elisabeth B, Boomsma, Dorret I, Calhoun, Vince, Crespo-Facorro, Benedicto, Deary, Ian J, Hulshoff Pol, Hilleke, Ophoff, Roel A, Pausova, Zdenka, Sachdev, Perminder S, Saykin, Andrew, Wright, Margaret J, Thompson, Paul M, Schumann, Gunter, and Desrivières, Sylvane
Subjects: Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Mental Health, Neurosciences, Genetics, Human Genome, Diabetes, Neurodegenerative, 2.1 Biological and endogenous factors, Aetiology, Neurological, Mental health, CpG Islands, DNA Methylation, Epigenesis, Genetic, Epigenome, Genome-Wide Association Study, Humans, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract: DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as a peripheral marker for the brain. Here, in an analysis of eleven international cohorts, totalling 3337 individuals, we report epigenome-wide meta-analyses of blood DNA methylation with volumes of the hippocampus, thalamus and nucleus accumbens (NAcc)-three subcortical regions selected for their associations with disease and heritability and volumetric variability. Analyses of individual CpGs revealed genome-wide significant associations with hippocampal volume at two loci. No significant associations were found for analyses of thalamus and nucleus accumbens volumes. Cluster-based analyses revealed additional differentially methylated regions (DMRs) associated with hippocampal volume. DNA methylation at these loci affected expression of proximal genes involved in learning and memory, stem cell maintenance and differentiation, fatty acid metabolism and type-2 diabetes. These DNA methylation marks, their interaction with genetic variants and their impact on gene expression offer new insights into the relationship between epigenetic variation and brain structure and may provide the basis for biomarker discovery in neurodegeneration and neuropsychiatric conditions.
Published: 2021

12. Correction: Obesity and brain structure in schizophrenia – ENIGMA study in 3021 individuals

Author: McWhinney, Sean R., Brosch, Katharina, Calhoun, Vince D., Crespo-Facorro, Benedicto, Crossley, Nicolas A., Dannlowski, Udo, Dickie, Erin, Dietze, Lorielle M. F., Donohoe, Gary, Du Plessis, Stefan, Ehrlich, Stefan, Emsley, Robin, Furstova, Petra, Glahn, David C., Gonzalez- Valderrama, Alfonso, Grotegerd, Dominik, Holleran, Laurena, Kircher, Tilo T. J., Knytl, Pavel, Kolenic, Marian, Lencer, Rebekka, Nenadić, Igor, Opel, Nils, Pfarr, Julia-Katharina, Rodrigue, Amanda L., Rootes-Murdy, Kelly, Ross, Alex J., Sim, Kang, Škoch, Antonín, Spaniel, Filip, Stein, Frederike, Švancer, Patrik, Tordesillas-Gutiérrez, Diana, Undurraga, Juan, Vázquez-Bourgon, Javier, Voineskos, Aristotle, Walton, Esther, Weickert, Thomas W., Weickert, Cynthia Shannon, Thompson, Paul M., van Erp, Theo G. M., Turner, Jessica A., and Hajek, Tomas
Published: 2024
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13. Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium

Author: van Velzen, Laura S., Dauvermann, Maria R., Colic, Lejla, Villa, Luca M., Savage, Hannah S., Toenders, Yara J., Zhu, Alyssa H., Bright, Joanna K., Campos, Adrián I., Salminen, Lauren E., Ambrogi, Sonia, Ayesa-Arriola, Rosa, Banaj, Nerisa, Başgöze, Zeynep, Bauer, Jochen, Blair, Karina, Blair, Robert James, Brosch, Katharina, Cheng, Yuqi, Colle, Romain, Connolly, Colm G., Corruble, Emmanuelle, Couvy-Duchesne, Baptiste, Crespo-Facorro, Benedicto, Cullen, Kathryn R., Dannlowski, Udo, Davey, Christopher G., Dohm, Katharina, Fullerton, Janice M., Gonul, Ali Saffet, Gotlib, Ian H., Grotegerd, Dominik, Hahn, Tim, Harrison, Ben J., He, Mengxin, Hickie, Ian B., Ho, Tiffany C., Iorfino, Frank, Jansen, Andreas, Jollant, Fabrice, Kircher, Tilo, Klimes-Dougan, Bonnie, Klug, Melissa, Leehr, Elisabeth J., Lippard, Elizabeth T. C., McLaughlin, Katie A., Meinert, Susanne, Miller, Adam Bryant, Mitchell, Philip B., Mwangi, Benson, Nenadić, Igor, Ojha, Amar, Overs, Bronwyn J., Pfarr, Julia-Katharina, Piras, Fabrizio, Ringwald, Kai G., Roberts, Gloria, Romer, Georg, Sanches, Marsal, Sheridan, Margaret A., Soares, Jair C., Spalletta, Gianfranco, Stein, Frederike, Teresi, Giana I., Tordesillas-Gutiérrez, Diana, Uyar-Demir, Aslihan, van der Wee, Nic J. A., van der Werff, Steven J., Vermeiren, Robert R. J. M., Winter, Alexandra, Wu, Mon-Ju, Yang, Tony T., Thompson, Paul M., Rentería, Miguel E., Jahanshad, Neda, Blumberg, Hilary P., van Harmelen, Anne-Laura, and Schmaal, Lianne
Published: 2022
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14. Deep Learning for Quality Control of Subcortical Brain 3D Shape Models

Author: Petrov, Dmitry, Kuznetsov, Boris A. Gutman Egor, van Erp, Theo G. M., Turner, Jessica A., Schmaal, Lianne, Veltman, Dick, Wang, Lei, Alpert, Kathryn, Isaev, Dmitry, Zavaliangos-Petropulu, Artemis, Ching, Christopher R. K., Calhoun, Vince, Glahn, David, Satterthwaite, Theodore D., Andreassen, Ole Andreas, Borgwardt, Stefan, Howells, Fleur, Groenewold, Nynke, Voineskos, Aristotle, Radua, Joaquim, Potkin, Steven G., Crespo-Facorro, Benedicto, Tordesillas-Gutierrez, Diana, Shen, Li, Lebedeva, Irina, Spalletta, Gianfranco, Donohoe, Gary, Kochunov, Peter, Rosa, Pedro G. P., James, Anthony, Dannlowski, Udo, Baune, Bernhard T., Aleman, Andre, Gotlib, Ian H., Walter, Henrik, Walter, Martin, Soares, Jair C., Ehrlich, Stefan, Gur, Ruben C., Doan, N. Trung, Agartz, Ingrid, Westlye, Lars T., Harrisberger, Fabienne, Riecher-Rossler, Anita, Uhlmann, Anne, Stein, Dan J., Dickie, Erin W., Pomarol-Clotet, Edith, Fuentes-Claramonte, Paola, Canales-Rodriguez, Erick Jorge, Salvador, Raymond, Huang, Alexander J., Roiz-Santianez, Roberto, Cong, Shan, Tomyshev, Alexander, Piras, Fabrizio, Vecchio, Daniela, Banaj, Nerisa, Ciullo, Valentina, Hong, Elliot, Busatto, Geraldo, Zanetti, Marcus V., Serpa, Mauricio H., Cervenka, Simon, Kelly, Sinead, Grotegerd, Dominik, Sacchet, Matthew D., Veer, Ilya M., Li, Meng, Wu, Mon-Ju, Irungu, Benson, Walton, Esther, and Thompson, Paul M.
Subjects: Quantitative Biology - Neurons and Cognition
Abstract: We present several deep learning models for assessing the morphometric fidelity of deep grey matter region models extracted from brain MRI. We test three different convolutional neural net architectures (VGGNet, ResNet and Inception) over 2D maps of geometric features. Further, we present a novel geometry feature augmentation technique based on a parametric spherical mapping. Finally, we present an approach for model decision visualization, allowing human raters to see the areas of subcortical shapes most likely to be deemed of failing quality by the machine. Our training data is comprised of 5200 subjects from the ENIGMA Schizophrenia MRI cohorts, and our test dataset contains 1500 subjects from the ENIGMA Major Depressive Disorder cohorts. Our final models reduce human rater time by 46-70%. ResNet outperforms VGGNet and Inception for all of our predictive tasks., Comment: Accepted to Shape in Medical Imaging (ShapeMI) workshop at MICCAI 2018. arXiv admin note: substantial text overlap with arXiv:1707.06353
Published: 2018

15. Naturalistic study on the use of clozapine in the early phases of non-affective psychosis: A 10-year follow-up study in the PAFIP-10 cohort

Author: Moreno-Sancho, Lara, Juncal-Ruiz, Maria, Vázquez-Bourgon, Javier, Ortiz-Garcia de la Foz, Victor, Mayoral-van Son, Jacqueline, Tordesillas-Gutierrez, Diana, Setien-Suero, Esther, Ayesa-Arriola, Rosa, and Crespo-Facorro, Benedicto
Published: 2022
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16. The retinal ganglion cell layer reflects neurodegenerative changes in cognitively unimpaired individuals

Author: López-de-Eguileta, Alicia, López-García, Sara, Lage, Carmen, Pozueta, Ana, García-Martínez, María, Kazimierczak, Martha, Bravo, María, Irure, Juan, López-Hoyos, Marcos, Muñoz-Cacho, Pedro, Rodríguez-Perez, Noelia, Tordesillas-Gutiérrez, Diana, Goikoetxea, Alexander, Nebot, Claudia, Rodríguez-Rodríguez, Eloy, Casado, Alfonso, and Sánchez-Juan, Pascual
Published: 2022
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17. Neuroimaging correlates of insight in non-affective psychosis: A systematic review and meta-analysis

Author: Soldevila-Matías, Pau, Schoretsanitis, Georgios, Tordesillas-Gutierrez, Diana, Cuesta, Manuel J., de Filippis, Renato, Ayesa-Arriola, Rosa, González-Vivas, Carlos, Setién-Suero, Esther, Verdolini, Norma, Sanjuán, Julio, Radua, Joaquim, and Crespo-Facorro, Benedicto
Published: 2022
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18. Precuneus and insular hypoactivation during cognitive processing in first-episode psychosis: Systematic review and meta-analysis of fMRI studies

Author: Soldevila-Matías, Pau, Albajes-Eizagirre, Anton, Radua, Joaquim, García-Martí, Gracián, Rubio, José M., Tordesillas-Gutierrez, Diana, Fuentes-Durá, Inmaculada, Solanes, Aleix, Fortea, Lydia, Oliver, Dominic, and Sanjuán, Julio
Published: 2022
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19. Machine Learning for Large-Scale Quality Control of 3D Shape Models in Neuroimaging

Author: Petrov, Dmitry, Gutman, Boris A., Shih-Hua, Yu, van Erp, Theo G. M., Turner, Jessica A., Schmaal, Lianne, Veltman, Dick, Wang, Lei, Alpert, Kathryn, Isaev, Dmitry, Zavaliangos-Petropulu, Artemis, Ching, Christopher R. K., Calhoun, Vince, Glahn, David, Satterthwaite, Theodore D., Andreasen, Ole Andreas, Borgwardt, Stefan, Howells, Fleur, Groenewold, Nynke, Voineskos, Aristotle, Radua, Joaquim, Potkin, Steven G., Crespo-Facorro, Benedicto, Tordesillas-Gutierrez, Diana, Shen, Li, Lebedeva, Irina, Spalletta, Gianfranco, Donohoe, Gary, Kochunov, Peter, Rosa, Pedro G. P., James, Anthony, Dannlowski, Udo, Baune, Bernhard T., Aleman, Andre, Gotlib, Ian H., Walter, Henrik, Walter, Martin, Soares, Jair C., Ehrlich, Stefan, Gur, Ruben C., Doan, N. Trung, Agartz, Ingrid, Westlye, Lars T., Harrisberger, Fabienne, Riecher-Rossler, Anita, Uhlmann, Anne, Stein, Dan J., Dickie, Erin W., Pomarol-Clotet, Edith, Fuentes-Claramonte, Paola, Canales-Rodriguez, Erick Jorge, Salvador, Raymond, Huang, Alexander J., Roiz-Santianez, Roberto, Cong, Shan, Tomyshev, Alexander, Piras, Fabrizio, Vecchio, Daniela, Banaj, Nerisa, Ciullo, Valentina, Hong, Elliot, Busatto, Geraldo, Zanetti, Marcus V., Serpa, Mauricio H., Cervenka, Simon, Kelly, Sinead, Grotegerd, Dominik, Sacchet, Matthew D., Veer, Ilya M., Li, Meng, Wu, Mon-Ju, Irungu, Benson, Walton, Esther, and Thompson, Paul M.
Subjects: Quantitative Biology - Quantitative Methods
Abstract: As very large studies of complex neuroimaging phenotypes become more common, human quality assessment of MRI-derived data remains one of the last major bottlenecks. Few attempts have so far been made to address this issue with machine learning. In this work, we optimize predictive models of quality for meshes representing deep brain structure shapes. We use standard vertex-wise and global shape features computed homologously across 19 cohorts and over 7500 human-rated subjects, training kernelized Support Vector Machine and Gradient Boosted Decision Trees classifiers to detect meshes of failing quality. Our models generalize across datasets and diseases, reducing human workload by 30-70\%, or equivalently hundreds of human rater hours for datasets of comparable size, with recall rates approaching inter-rater reliability., Comment: Arxiv version of the MICCAI 2017 Machine Learning in Medical Imaging workshop paper
Published: 2017

20. Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium.

Author: van Erp, Theo GM, Walton, Esther, Hibar, Derrek P, Schmaal, Lianne, Jiang, Wenhao, Glahn, David C, Pearlson, Godfrey D, Yao, Nailin, Fukunaga, Masaki, Hashimoto, Ryota, Okada, Naohiro, Yamamori, Hidenaga, Bustillo, Juan R, Clark, Vincent P, Agartz, Ingrid, Mueller, Bryon A, Cahn, Wiepke, de Zwarte, Sonja MC, Hulshoff Pol, Hilleke E, Kahn, René S, Ophoff, Roel A, van Haren, Neeltje EM, Andreassen, Ole A, Dale, Anders M, Doan, Nhat Trung, Gurholt, Tiril P, Hartberg, Cecilie B, Haukvik, Unn K, Jørgensen, Kjetil N, Lagerberg, Trine V, Melle, Ingrid, Westlye, Lars T, Gruber, Oliver, Kraemer, Bernd, Richter, Anja, Zilles, David, Calhoun, Vince D, Crespo-Facorro, Benedicto, Roiz-Santiañez, Roberto, Tordesillas-Gutiérrez, Diana, Loughland, Carmel, Carr, Vaughan J, Catts, Stanley, Cropley, Vanessa L, Fullerton, Janice M, Green, Melissa J, Henskens, Frans A, Jablensky, Assen, Lenroot, Rhoshel K, Mowry, Bryan J, Michie, Patricia T, Pantelis, Christos, Quidé, Yann, Schall, Ulrich, Scott, Rodney J, Cairns, Murray J, Seal, Marc, Tooney, Paul A, Rasser, Paul E, Cooper, Gavin, Shannon Weickert, Cynthia, Weickert, Thomas W, Morris, Derek W, Hong, Elliot, Kochunov, Peter, Beard, Lauren M, Gur, Raquel E, Gur, Ruben C, Satterthwaite, Theodore D, Wolf, Daniel H, Belger, Aysenil, Brown, Gregory G, Ford, Judith M, Macciardi, Fabio, Mathalon, Daniel H, O'Leary, Daniel S, Potkin, Steven G, Preda, Adrian, Voyvodic, James, Lim, Kelvin O, McEwen, Sarah, Yang, Fude, Tan, Yunlong, Tan, Shuping, Wang, Zhiren, Fan, Fengmei, Chen, Jingxu, Xiang, Hong, Tang, Shiyou, Guo, Hua, Wan, Ping, Wei, Dong, Bockholt, Henry J, Ehrlich, Stefan, Wolthusen, Rick PF, King, Margaret D, Shoemaker, Jody M, Sponheim, Scott R, De Haan, Lieuwe, and Koenders, Laura
Subjects: Karolinska Schizophrenia Project, Brain, Frontal Lobe, Prefrontal Cortex, Temporal Lobe, Humans, Magnetic Resonance Imaging, Severity of Illness Index, Linear Models, Case-Control Studies, Schizophrenia, Age of Onset, Adolescent, Adult, Aged, Middle Aged, Child, Female, Male, Young Adult, Neuroimaging, Cortical, Imaging, Meta-analysis, Surface area, Thickness, Serious Mental Illness, Biomedical Imaging, Mental Health, Clinical Research, Neurosciences, Brain Disorders, Mental health, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract: BackgroundThe profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group.MethodsThe study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; range, 11-78 years; 66% male) and 5098 healthy volunteers (mean age, 32.8 years; range, 10-87 years; 53% male) assessed with standardized methods at 39 centers worldwide.ResultsCompared with healthy volunteers, individuals with schizophrenia have widespread thinner cortex (left/right hemisphere: Cohen's d = -0.530/-0.516) and smaller surface area (left/right hemisphere: Cohen's d = -0.251/-0.254), with the largest effect sizes for both in frontal and temporal lobe regions. Regional group differences in cortical thickness remained significant when statistically controlling for global cortical thickness, suggesting regional specificity. In contrast, effects for cortical surface area appear global. Case-control, negative, cortical thickness effect sizes were two to three times larger in individuals receiving antipsychotic medication relative to unmedicated individuals. Negative correlations between age and bilateral temporal pole thickness were stronger in individuals with schizophrenia than in healthy volunteers. Regional cortical thickness showed significant negative correlations with normalized medication dose, symptom severity, and duration of illness and positive correlations with age at onset.ConclusionsThe findings indicate that the ENIGMA meta-analysis approach can achieve robust findings in clinical neuroscience studies; also, medication effects should be taken into account in future genetic association studies of cortical thickness in schizophrenia.
Published: 2018

21. Normative modelling of brain morphometry across the lifespan with CentileBrain: algorithm benchmarking and model optimisation

Author: Ge, Ruiyang, primary, Yu, Yuetong, additional, Qi, Yi Xuan, additional, Fan, Yu-nan, additional, Chen, Shiyu, additional, Gao, Chuntong, additional, Haas, Shalaila S, additional, New, Faye, additional, Boomsma, Dorret I, additional, Brodaty, Henry, additional, Brouwer, Rachel M, additional, Buckner, Randy, additional, Caseras, Xavier, additional, Crivello, Fabrice, additional, Crone, Eveline A, additional, Erk, Susanne, additional, Fisher, Simon E, additional, Franke, Barbara, additional, Glahn, David C, additional, Dannlowski, Udo, additional, Grotegerd, Dominik, additional, Gruber, Oliver, additional, Hulshoff Pol, Hilleke E, additional, Schumann, Gunter, additional, Tamnes, Christian K, additional, Walter, Henrik, additional, Wierenga, Lara M, additional, Jahanshad, Neda, additional, Thompson, Paul M, additional, Frangou, Sophia, additional, Agartz, Ingrid, additional, Asherson, Philip, additional, Ayesa-Arriola, Rosa, additional, Banaj, Nerisa, additional, Banaschewski, Tobias, additional, Baumeister, Sarah, additional, Bertolino, Alessandro, additional, Borgwardt, Stefan, additional, Bourque, Josiane, additional, Brandeis, Daniel, additional, Breier, Alan, additional, Buitelaar, Jan K, additional, Cannon, Dara M, additional, Cervenka, Simon, additional, Conrod, Patricia J, additional, Crespo-Facorro, Benedicto, additional, Davey, Christopher G, additional, de Haan, Lieuwe, additional, de Zubicaray, Greig I, additional, Di Giorgio, Annabella, additional, Frodl, Thomas, additional, Gruner, Patricia, additional, Gur, Raquel E, additional, Gur, Ruben C, additional, Harrison, Ben J, additional, Hatton, Sean N, additional, Hickie, Ian, additional, Howells, Fleur M, additional, Huyser, Chaim, additional, Jernigan, Terry L, additional, Jiang, Jiyang, additional, Joska, John A, additional, Kahn, René S, additional, Kalnin, Andrew J, additional, Kochan, Nicole A, additional, Koops, Sanne, additional, Kuntsi, Jonna, additional, Lagopoulos, Jim, additional, Lazaro, Luisa, additional, Lebedeva, Irina S, additional, Lochner, Christine, additional, Martin, Nicholas G, additional, Mazoyer, Bernard, additional, McDonald, Brenna C, additional, McDonald, Colm, additional, McMahon, Katie L, additional, Medland, Sarah, additional, Modabbernia, Amirhossein, additional, Mwangi, Benson, additional, Nakao, Tomohiro, additional, Nyberg, Lars, additional, Piras, Fabrizio, additional, Portella, Maria J, additional, Qiu, Jiang, additional, Roffman, Joshua L, additional, Sachdev, Perminder S, additional, Sanford, Nicole, additional, Satterthwaite, Theodore D, additional, Saykin, Andrew J, additional, Sellgren, Carl M, additional, Sim, Kang, additional, Smoller, Jordan W, additional, Soares, Jair C, additional, Sommer, Iris E, additional, Spalletta, Gianfranco, additional, Stein, Dan J, additional, Thomopoulos, Sophia I, additional, Tomyshev, Alexander S, additional, Tordesillas-Gutiérrez, Diana, additional, Trollor, Julian N, additional, van 't Ent, Dennis, additional, van den Heuvel, Odile A, additional, van Erp, Theo GM, additional, van Haren, Neeltje EM, additional, Vecchio, Daniela, additional, Veltman, Dick J, additional, Wang, Yang, additional, Weber, Bernd, additional, Wei, Dongtao, additional, Wen, Wei, additional, Westlye, Lars T, additional, Williams, Steven CR, additional, Wright, Margaret J, additional, Wu, Mon-Ju, additional, and Yu, Kevin, additional
Published: 2024
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22. Comparison of aripiprazole and risperidone effectiveness in first episode non-affective psychosis: Rationale and design of a prospective, randomized, 3-phase, investigator-initiated study (PAFIP-3)

Author: Son J., Mayoral-van, Gómez-Revuelta, Marcos, Ayesa-Arriola, Rosa, Vázquez-Bourgón, Javier, Foz, Víctor Ortiz-García de la, Ruiz-Veguilla, Miguel, Garrido, Nathalia, Tordesillas-Gutiérrez, Diana, Setién-Suero, Esther, and Crespo-Facorro, Benedicto
Published: 2021
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23. Long term cortical thickness changes after a first episode of non- affective psychosis: The 10 year follow-up of the PAFIP cohort

Author: Rodriguez-Perez, Noelia, Ayesa-Arriola, Rosa, Ortiz-García de la Foz, Victor, Setien-Suero, Esther, Tordesillas-Gutierrez, Diana, and Crespo-Facorro, Benedicto
Published: 2021
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24. Differences between psychiatric disorders in the clinical and functional effectiveness of an acute psychiatric day hospital, for acutely ill psychiatric patients

Author: Vázquez-Bourgon, Javier, Gómez Ruiz, Elsa, Hoyuela Zatón, Fernando, Salvador Carulla, Luis, Ayesa Arriola, Rosa, Tordesillas Gutiérrez, Diana, and Crespo Facorro, Benedicto
Published: 2021
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25. Diferencias en la efectividad clínica y funcional, entre trastornos psiquiátricos, de un hospital de día psiquiátrico de agudos para pacientes con enfermedad mental aguda

Author: Vázquez-Bourgon, Javier, Gómez Ruiz, Elsa, Hoyuela Zatón, Fernando, Salvador Carulla, Luis, Ayesa Arriola, Rosa, Tordesillas Gutiérrez, Diana, and Crespo Facorro, Benedicto
Published: 2021
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26. Beyond the global brain differences: Intraindividual variability differences in 1q21.1 distal and 15q11.2 BP1-BP2 deletion carriers

Author: European Commission, European Research Council, Instituto de Salud Carlos III, Fundación Marques de Valdecilla, Fundació Seny, Instituto de Investigación Marqués de Valdecilla, Boen, Rune, Crespo-Facorro, Benedicto, Tordesillas-Gutiérrez, Diana, European Commission, European Research Council, Instituto de Salud Carlos III, Fundación Marques de Valdecilla, Fundació Seny, Instituto de Investigación Marqués de Valdecilla, Boen, Rune, Crespo-Facorro, Benedicto, and Tordesillas-Gutiérrez, Diana
Abstract: [Background]: Carriers of the 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants exhibit regional and global brain differences compared with noncarriers. However, interpreting regional differences is challenging if a global difference drives the regional brain differences. Intraindividual variability measures can be used to test for regional differences beyond global differences in brain structure., [Methods]: Magnetic resonance imaging data were used to obtain regional brain values for 1q21.1 distal deletion (n = 30) and duplication (n = 27) and 15q11.2 BP1-BP2 deletion (n = 170) and duplication (n = 243) carriers and matched noncarriers (n = 2350). Regional intra-deviation scores, i.e., the standardized difference between an individual's regional difference and global difference, were used to test for regional differences that diverge from the global difference., [Results]: For the 1q21.1 distal deletion carriers, cortical surface area for regions in the medial visual cortex, posterior cingulate, and temporal pole differed less and regions in the prefrontal and superior temporal cortex differed more than the global difference in cortical surface area. For the 15q11.2 BP1-BP2 deletion carriers, cortical thickness in regions in the medial visual cortex, auditory cortex, and temporal pole differed less and the prefrontal and somatosensory cortex differed more than the global difference in cortical thickness., [Conclusions]: We find evidence for regional effects beyond differences in global brain measures in 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants. The results provide new insight into brain profiling of the 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants, with the potential to increase understanding of the mechanisms involved in altered neurodevelopment.
Published: 2024

27. Neuroharmony: A new tool for harmonizing volumetric MRI data from unseen scanners

Author: Garcia-Dias, Rafael, Scarpazza, Cristina, Baecker, Lea, Vieira, Sandra, Pinaya, Walter H.L., Corvin, Aiden, Redolfi, Alberto, Nelson, Barnaby, Crespo-Facorro, Benedicto, McDonald, Colm, Tordesillas-Gutiérrez, Diana, Cannon, Dara, Mothersill, David, Hernaus, Dennis, Morris, Derek, Setien-Suero, Esther, Donohoe, Gary, Frisoni, Giovanni, Tronchin, Giulia, Sato, João, Marcelis, Machteld, Kempton, Matthew, van Haren, Neeltje E.M., Gruber, Oliver, McGorry, Patrick, Amminger, Paul, McGuire, Philip, Gong, Qiyong, Kahn, René S., Ayesa-Arriola, Rosa, van Amelsvoort, Therese, Ortiz-García de la Foz, Victor, Calhoun, Vince, Cahn, Wiepke, and Mechelli, Andrea
Published: 2020
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28. Brain grey matter abnormalities in first episode non-affective psychosis patients with suicidal behaviours: The role of neurocognitive functioning

Author: Canal-Rivero, Manuel, Tordesillas-Gutiérrez, Diana, Ruiz-Veguilla, Miguel, Ortiz-García de la Foz, Victor, Cuevas-Esteban, Jorge, Marco de Lucas, Enrique, Vázquez-Bourgon, Javier, Ayesa-Arriola, Rosa, and Crespo-Facorro, Benedicto
Published: 2020
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29. Correction: Obesity and brain structure in schizophrenia – ENIGMA study in 3021 individuals

Author: McWhinney, Sean R., Brosch, Katharina, Calhoun, Vince D., Crespo-Facorro, Benedicto, Crossley, Nicolas A., Dannlowski, Udo, Dickie, Erin, Dietze, Lorielle M. F., Donohoe, Gary, Du Plessis, Stefan, Ehrlich, Stefan, Emsley, Robin, Furstova, Petra, Glahn, David C., Gonzalez- Valderrama, Alfonso, Grotegerd, Dominik, Holleran, Laurena, Kircher, Tilo T. J., Knytl, Pavel, Kolenic, Marian, Lencer, Rebekka, Nenadić, Igor, Opel, Nils, Pfarr, Julia-Katharina, Rodrigue, Amanda L., Rootes-Murdy, Kelly, Ross, Alex J., Sim, Kang, Škoch, Antonín, Spaniel, Filip, Stein, Frederike, Švancer, Patrik, Tordesillas-Gutiérrez, Diana, Undurraga, Juan, Váquez-Bourgon, Javier, Voineskos, Aristotle, Walton, Esther, Weickert, Thomas W., Weickert, Cynthia Shannon, Thompson, Paul M., van Erp, Theo G. M., Turner, Jessica A., and Hajek, Tomas
Published: 2022
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30. Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium

Author: Farde, Lars, Flyckt, Lena, Engberg, Göran, Erhardt, Sophie, Fatouros-Bergman, Helena, Cervenka, Simon, Schwieler, Lilly, Piehl, Fredrik, Agartz, Ingrid, Collste, Karin, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, van Erp, Theo G.M., Walton, Esther, Hibar, Derrek P., Schmaal, Lianne, Jiang, Wenhao, Glahn, David C., Pearlson, Godfrey D., Yao, Nailin, Fukunaga, Masaki, Hashimoto, Ryota, Okada, Naohiro, Yamamori, Hidenaga, Bustillo, Juan R., Clark, Vincent P., Mueller, Bryon A., Cahn, Wiepke, de Zwarte, Sonja M.C., Hulshoff Pol, Hilleke E., Kahn, René S., Ophoff, Roel A., van Haren, Neeltje E.M., Andreassen, Ole A., Dale, Anders M., Doan, Nhat Trung, Gurholt, Tiril P., Hartberg, Cecilie B., Haukvik, Unn K., Jørgensen, Kjetil N., Lagerberg, Trine V., Melle, Ingrid, Westlye, Lars T., Gruber, Oliver, Kraemer, Bernd, Richter, Anja, Zilles, David, Calhoun, Vince D., Crespo-Facorro, Benedicto, Roiz-Santiañez, Roberto, Tordesillas-Gutiérrez, Diana, Loughland, Carmel, Carr, Vaughan J., Catts, Stanley, Cropley, Vanessa L., Fullerton, Janice M., Green, Melissa J., Henskens, Frans A., Jablensky, Assen, Lenroot, Rhoshel K., Mowry, Bryan J., Michie, Patricia T., Pantelis, Christos, Quidé, Yann, Schall, Ulrich, Scott, Rodney J., Cairns, Murray J., Seal, Marc, Tooney, Paul A., Rasser, Paul E., Cooper, Gavin, Shannon Weickert, Cynthia, Weickert, Thomas W., Morris, Derek W., Hong, Elliot, Kochunov, Peter, Beard, Lauren M., Gur, Raquel E., Gur, Ruben C., Satterthwaite, Theodore D., Wolf, Daniel H., Belger, Aysenil, Brown, Gregory G., Ford, Judith M., Macciardi, Fabio, Mathalon, Daniel H., O’Leary, Daniel S., Potkin, Steven G., Preda, Adrian, Voyvodic, James, Lim, Kelvin O., McEwen, Sarah, Yang, Fude, Tan, Yunlong, Tan, Shuping, Wang, Zhiren, Fan, Fengmei, Chen, Jingxu, Xiang, Hong, Tang, Shiyou, Guo, Hua, Wan, Ping, Wei, Dong, Bockholt, Henry J., Ehrlich, Stefan, Wolthusen, Rick P.F., King, Margaret D., Shoemaker, Jody M., Sponheim, Scott R., De Haan, Lieuwe, Koenders, Laura, Machielsen, Marise W., van Amelsvoort, Therese, Veltman, Dick J., Assogna, Francesca, Banaj, Nerisa, de Rossi, Pietro, Iorio, Mariangela, Piras, Fabrizio, Spalletta, Gianfranco, McKenna, Peter J., Pomarol-Clotet, Edith, Salvador, Raymond, Corvin, Aiden, Donohoe, Gary, Kelly, Sinead, Whelan, Christopher D., Dickie, Erin W., Rotenberg, David, Voineskos, Aristotle N., Ciufolini, Simone, Radua, Joaquim, Dazzan, Paola, Murray, Robin, Reis Marques, Tiago, Simmons, Andrew, Borgwardt, Stefan, Egloff, Laura, Harrisberger, Fabienne, Riecher-Rössler, Anita, Smieskova, Renata, Alpert, Kathryn I., Wang, Lei, Jönsson, Erik G., Koops, Sanne, Sommer, Iris E.C., Bertolino, Alessandro, Bonvino, Aurora, Di Giorgio, Annabella, Neilson, Emma, Mayer, Andrew R., Stephen, Julia M., Kwon, Jun Soo, Yun, Je-Yeon, Cannon, Dara M., McDonald, Colm, Lebedeva, Irina, Tomyshev, Alexander S., Akhadov, Tolibjohn, Kaleda, Vasily, Busatto, Geraldo F., Rosa, Pedro G.P., Serpa, Mauricio H., Zanetti, Marcus V., Hoschl, Cyril, Skoch, Antonin, Spaniel, Filip, Tomecek, David, Hagenaars, Saskia P., McIntosh, Andrew M., Whalley, Heather C., Lawrie, Stephen M., Knöchel, Christian, Oertel-Knöchel, Viola, Stäblein, Michael, Howells, Fleur M., Stein, Dan J., Temmingh, Henk S., Uhlmann, Anne, Lopez-Jaramillo, Carlos, Dima, Danai, McMahon, Agnes, Faskowitz, Joshua I., Gutman, Boris A., Jahanshad, Neda, Thompson, Paul M., and Turner, Jessica A.
Published: 2018
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31. Understanding sex differences in long-term outcomes after a first episode of psychosis

Author: Ayesa-Arriola, Rosa, de la Foz, Víctor Ortíz-García, Setién-Suero, Esther, Ramírez-Bonilla, María Luz, Suárez-Pinilla, Paula, Son, Jacqueline Mayoral-van, Vázquez-Bourgon, Javier, Juncal-Ruiz, María, Gómez-Revuelta, Marcos, Tordesillas-Gutiérrez, Diana, and Crespo-Facorro, Benedicto
Published: 2020
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32. Genetic variants for head size share genes and pathways with cancer

Author: Amouyel, Philippe, Arfanakis, Konstantinos, Aribisala, Benjamin S., Bastin, Mark E., Chauhan, Ganesh, Chen, Christopher, Cheng, Ching-Yu, de Jager, Philip L., Deary, Ian J., Fleischman, Debra A., Gottesman, Rebecca F., Gudnason, Vilmundur, Hilal, Saima, Hofer, Edith, Janowitz, Deborah, Jukema, J. Wouter, Liewald, David C.M., Lopez, Lorna M., Lopez, Oscar, Luciano, Michelle, Martinez, Oliver, Niessen, Wiro J., Nyquist, Paul, Rotter, Jerome I., Rundek, Tatjana, Sacco, Ralph L., Schmidt, Helena, Tiemeier, Henning, Trompet, Stella, van der Grond, Jeroen, Völzke, Henry, Wardlaw, Joanna M., Yanek, Lisa, Yang, Jingyun, Agartz, Ingrid, Alhusaini, Saud, Almasy, Laura, Ames, David, Amunts, Katrin, Andreassen, Ole A., Armstrong, Nicola, Bernard, Manon, Blangero, John, Blanken, Laura M.E., Boks, Marco P., Boomsma, Dorret I., Brickman, Adam M., Brodaty, Henry, Buckner, Randy L., Buitelaar, Jan K., Cannon, Dara M., Carr, Vaughan J., Catts, Stanley V., Chakravarty, M. Mallar, Chen, Qiang, Ching, Christopher R.K., Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E., Davies, Gareth E., de Geus, Eco J.C., de Zubicaray, Greig I., den Braber, Anouk, Desrivières, Sylvane, Dillman, Allissa, Djurovic, Srdjan, Drevets, Wayne C., Duggirala, Ravi, Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fedko, Iryna O., Fernández, Guillén, Fisher, Simon E., Foroud, Tatiana M., Ge, Tian, Giddaluru, Sudheer, Glahn, David C., Goldman, Aaron L., Green, Robert C., Greven, Corina U., Grimm, Oliver, Hansell, Narelle K., Hartman, Catharina A., Hashimoto, Ryota, Heinz, Andreas, Henskens, Frans, Hibar, Derrek P., Ho, Beng-Choon, Hoekstra, Pieter J., Holmes, Avram J., Hoogman, Martine, Hottenga, Jouke-Jan, Hulshoff Pol, Hilleke E., Jablensky, Assen, Jenkinson, Mark, Jia, Tianye, Jöckel, Karl-Heinz, Jönsson, Erik G., Kim, Sungeun, Klein, Marieke, Kochunov, Peter, Kwok, John B., Lawrie, Stephen M., Le Hellard, Stephanie, Lemaître, Hervé, Loughland, Carmel, Marquand, Andre F., Martin, Nicholas G., Martinot, Jean-Luc, Matarin, Mar, Mathalon, Daniel H., Mather, Karen A., Mattay, Venkata S., McDonald, Colm, McMahon, Francis J., McMahon, Katie L., E, Rebekah, McWhirter, Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Michie, Patricia T., Milaneschi, Yuri, Morris, Derek W., Mowry, Bryan, Nho, Kwangsik, Nichols, Thomas E., Nöthen, Markus N., Olvera, Rene L., Oosterlaan, Jaap, Ophoff, Roel A., Pandolfo, Massimo, Pantelis, Christos, Pappa, Irene, Penninx, Brenda, Pike, G. Bruce, Rasser, Paul E., Rentería, Miguel E., Reppermund, Simone, Rietschel, Marcella, Risacher, Shannon L., Romanczuk-Seiferth, Nina, Rose, Emma Jane, Sachdev, Perminder S., Sämann, Philipp G., Saykin, Andrew J., Schall, Ulrich, Schofield, Peter R., Schramm, Sara, Schumann, Gunter, Scott, Rodney, Shen, Li, Sisodiya, Sanjay M., Soininen, Hilkka, Sprooten, Emma, Srikanth, Velandai, Steen, Vidar M., Strike, Lachlan T., Thalamuthu, Anbupalam, Toga, Arthur W., Tooney, Paul, Tordesillas-Gutiérrez, Diana, Turner, Jessica A., Valdés Hernández, Maria del C., van der Meer, Dennis, Van der Wee, Nic J.A., Van Haren, Neeltje E.M., van 't Ent, Dennis, Veltman, Dick J., Walter, Henrik, Weinberger, Daniel R., Weiner, Michael W., Wen, Wei, Westlye, Lars T., Westman, Eric, Winkler, Anderson M., Woldehawariat, Girma, Wright, Margaret J., Wu, Jingqin, Knol, Maria J., Poot, Raymond A., Evans, Tavia E., Satizabal, Claudia L., Mishra, Aniket, Sargurupremraj, Muralidharan, van der Auwera, Sandra, Duperron, Marie-Gabrielle, Jian, Xueqiu, Hostettler, Isabel C., van Dam-Nolen, Dianne H.K., Lamballais, Sander, Pawlak, Mikolaj A., Lewis, Cora E., Carrion-Castillo, Amaia, van Erp, Theo G.M., Reinbold, Céline S., Shin, Jean, Scholz, Markus, Håberg, Asta K., Kämpe, Anders, Li, Gloria H.Y., Avinun, Reut, Atkins, Joshua R., Hsu, Fang-Chi, Amod, Alyssa R., Lam, Max, Tsuchida, Ami, Teunissen, Mariël W.A., Aygün, Nil, Patel, Yash, Liang, Dan, Beiser, Alexa S., Beyer, Frauke, Bis, Joshua C., Bos, Daniel, Bryan, R. Nick, Bülow, Robin, Caspers, Svenja, Catheline, Gwenaëlle, Cecil, Charlotte A.M., Dalvie, Shareefa, Dartigues, Jean-François, DeCarli, Charles, Enlund-Cerullo, Maria, Ford, Judith M., Franke, Barbara, Freedman, Barry I., Friedrich, Nele, Green, Melissa J., Haworth, Simon, Helmer, Catherine, Hoffmann, Per, Homuth, Georg, Ikram, M. Kamran, Jack, Clifford R., Jr., Jahanshad, Neda, Jockwitz, Christiane, Kamatani, Yoichiro, Knodt, Annchen R., Li, Shuo, Lim, Keane, Longstreth, W.T., Macciardi, Fabio, Mäkitie, Outi, Mazoyer, Bernard, Medland, Sarah E., Miyamoto, Susumu, Moebus, Susanne, Mosley, Thomas H., Muetzel, Ryan, Mühleisen, Thomas W., Nagata, Manabu, Nakahara, Soichiro, Palmer, Nicholette D., Pausova, Zdenka, Preda, Adrian, Quidé, Yann, Reay, William R., Roshchupkin, Gennady V., Schmidt, Reinhold, Schreiner, Pamela J., Setoh, Kazuya, Shapland, Chin Yang, Sidney, Stephen, St Pourcain, Beate, Stein, Jason L., Tabara, Yasuharu, Teumer, Alexander, Uhlmann, Anne, van der Lugt, Aad, Vernooij, Meike W., Werring, David J., Windham, B. Gwen, Witte, A. Veronica, Wittfeld, Katharina, Yang, Qiong, Yoshida, Kazumichi, Brunner, Han G., Le Grand, Quentin, Sim, Kang, Stein, Dan J., Bowden, Donald W., Cairns, Murray J., Hariri, Ahmad R., Cheung, Ching-Lung, Andersson, Sture, Villringer, Arno, Paus, Tomas, Cichon, Sven, Calhoun, Vince D., Crivello, Fabrice, Launer, Lenore J., White, Tonya, Koudstaal, Peter J., Houlden, Henry, Fornage, Myriam, Matsuda, Fumihiko, Grabe, Hans J., Ikram, M. Arfan, Debette, Stéphanie, Thompson, Paul M., Seshadri, Sudha, and Adams, Hieab H.H.
Published: 2024
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33. Correction: Obesity and brain structure in schizophrenia – ENIGMA study in 3021 individuals

Author: McWhinney, Sean R., primary, Brosch, Katharina, additional, Calhoun, Vince D., additional, Crespo-Facorro, Benedicto, additional, Crossley, Nicolas A., additional, Dannlowski, Udo, additional, Dickie, Erin, additional, Dietze, Lorielle M. F., additional, Donohoe, Gary, additional, Du Plessis, Stefan, additional, Ehrlich, Stefan, additional, Emsley, Robin, additional, Furstova, Petra, additional, Glahn, David C., additional, Gonzalez- Valderrama, Alfonso, additional, Grotegerd, Dominik, additional, Holleran, Laurena, additional, Kircher, Tilo T. J., additional, Knytl, Pavel, additional, Kolenic, Marian, additional, Lencer, Rebekka, additional, Nenadić, Igor, additional, Opel, Nils, additional, Pfarr, Julia-Katharina, additional, Rodrigue, Amanda L., additional, Rootes-Murdy, Kelly, additional, Ross, Alex J., additional, Sim, Kang, additional, Škoch, Antonín, additional, Spaniel, Filip, additional, Stein, Frederike, additional, Švancer, Patrik, additional, Tordesillas-Gutiérrez, Diana, additional, Undurraga, Juan, additional, Vázquez-Bourgon, Javier, additional, Voineskos, Aristotle, additional, Walton, Esther, additional, Weickert, Thomas W., additional, Weickert, Cynthia Shannon, additional, Thompson, Paul M., additional, van Erp, Theo G. M., additional, Turner, Jessica A., additional, and Hajek, Tomas, additional
Published: 2023
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34. In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis

Author: Instituto de Salud Carlos III, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Fundación Mutua Madrileña, Fundación Alicia Koplowitz, Fundación Alonso Lozano, AstraZeneca, National Institutes of Health (US), Comunidad de Madrid, Instituto de Investigación Marqués de Valdecilla, Barth, Claudia, Crespo-Facorro, Benedicto, Tordesillas-Gutiérrez, Diana, Instituto de Salud Carlos III, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Fundación Mutua Madrileña, Fundación Alicia Koplowitz, Fundación Alonso Lozano, AstraZeneca, National Institutes of Health (US), Comunidad de Madrid, Instituto de Investigación Marqués de Valdecilla, Barth, Claudia, Crespo-Facorro, Benedicto, and Tordesillas-Gutiérrez, Diana
Abstract: Emerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset <18 years). However, as neuroimaging methods vary and sample sizes are modest, results remain inconclusive. Using harmonized data processing protocols and a mega-analytic approach, we compared white matter microstructure in EOP and healthy controls using diffusion tensor imaging (DTI). Our sample included 321 adolescents with EOP (median age = 16.6 years, interquartile range (IQR) = 2.14, 46.4% females) and 265 adolescent healthy controls (median age = 16.2 years, IQR = 2.43, 57.7% females) pooled from nine sites. All sites extracted mean fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) for 25 white matter regions of interest per participant. ComBat harmonization was performed for all DTI measures to adjust for scanner differences. Multiple linear regression models were fitted to investigate case-control differences and associations with clinical variables in regional DTI measures. We found widespread lower FA in EOP compared to healthy controls, with the largest effect sizes in the superior longitudinal fasciculus (Cohen’s d = 0.37), posterior corona radiata (d = 0.32), and superior fronto‐occipital fasciculus (d = 0.31). We also found widespread higher RD and more localized higher MD and AD. We detected significant effects of diagnostic subgroup, sex, and duration of illness, but not medication status. Using the largest EOP DTI sample to date, our findings suggest a profile of widespread white matter microstructure alterations in adolescents with EOP, most prominently in male individuals with early-onset schizophrenia and individuals with a shorter duration of illness.
Published: 2023

35. Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

Author: National Institutes of Health (US), Instituto de Salud Carlos III, European Commission, European Research Council, Ministerio de Ciencia e Innovación (España), Fundación Marques de Valdecilla, Instituto de Investigación Marqués de Valdecilla, Fundación Alonso Lozano, Fundación Alicia Koplowitz, Schijven, Dick, Postema, Merel C., Fukunaga, Masaki, Tordesillas-Gutiérrez, Diana, Crespo-Facorro, Benedicto, Francks, Clyde, National Institutes of Health (US), Instituto de Salud Carlos III, European Commission, European Research Council, Ministerio de Ciencia e Innovación (España), Fundación Marques de Valdecilla, Instituto de Investigación Marqués de Valdecilla, Fundación Alonso Lozano, Fundación Alicia Koplowitz, Schijven, Dick, Postema, Merel C., Fukunaga, Masaki, Tordesillas-Gutiérrez, Diana, Crespo-Facorro, Benedicto, and Francks, Clyde
Abstract: Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.
Published: 2023

36. Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium

Author: National Institutes of Health (US), UK Research and Innovation, German Research Foundation, Generalitat de Catalunya, Instituto de Salud Carlos III, National Science Foundation (US), Fundación Alonso Lozano, Fundación Alicia Koplowitz, European Commission, National Health and Medical Research Council (Australia), European Research Council, Australian Research Council, Ministero della Salute, Ministerio de Ciencia e Innovación (España), Comunidad de Madrid, Constantinides, Constantinos, Crespo-Facorro, Benedicto, Tordesillas-Gutiérrez, Diana, Walton, Esther, National Institutes of Health (US), UK Research and Innovation, German Research Foundation, Generalitat de Catalunya, Instituto de Salud Carlos III, National Science Foundation (US), Fundación Alonso Lozano, Fundación Alicia Koplowitz, European Commission, National Health and Medical Research Council (Australia), European Research Council, Australian Research Council, Ministero della Salute, Ministerio de Ciencia e Innovación (España), Comunidad de Madrid, Constantinides, Constantinos, Crespo-Facorro, Benedicto, Tordesillas-Gutiérrez, Diana, and Walton, Esther
Abstract: Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study conducted by the ENIGMA Schizophrenia Working Group. The study included data from 26 cohorts worldwide, with a total of 2803 SZ patients (mean age 34.2 years; range 18-72 years; 67% male) and 2598 healthy controls (mean age 33.8 years, range 18-73 years, 55% male). Brain-predicted age was individually estimated using a model trained on independent data based on 68 measures of cortical thickness and surface area, 7 subcortical volumes, lateral ventricular volumes and total intracranial volume, all derived from T1-weighted brain magnetic resonance imaging (MRI) scans. Deviations from a healthy brain ageing trajectory were assessed by the difference between brain-predicted age and chronological age (brain-predicted age difference [brain-PAD]). On average, SZ patients showed a higher brain-PAD of +3.55 years (95% CI: 2.91, 4.19; I2 = 57.53%) compared to controls, after adjusting for age, sex and site (Cohen's d = 0.48). Among SZ patients, brain-PAD was not associated with specific clinical characteristics (age of onset, duration of illness, symptom severity, or antipsychotic use and dose). This large-scale collaborative study suggests advanced structural brain ageing in SZ. Longitudinal studies of SZ and a range of mental and somatic health outcomes will help to further evaluate the clinical implications of increased brain-PAD and its ability to be influenced by interventions.
Published: 2023

37. Brain ageing in schizophrenia:evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium

Author: Constantinides, Constantinos, Han, Laura K. M., Alloza, Clara, Antonucci, Linda Antonella, Arango, Celso, Ayesa-Arriola, Rosa, Banaj, Nerisa, Bertolino, Alessandro, Borgwardt, Stefan, Bruggemann, Jason, Bustillo, Juan, Bykhovski, Oleg, Calhoun, Vince, Carr, Vaughan, Catts, Stanley, Chung, Young-Chul, Crespo-Facorro, Benedicto, Díaz-Caneja, Covadonga M., Donohoe, Gary, Plessis, Stefan Du, Edmond, Jesse, Ehrlich, Stefan, Emsley, Robin, Eyler, Lisa T., Fuentes-Claramonte, Paola, Georgiadis, Foivos, Green, Melissa, Guerrero-Pedraza, Amalia, Ha, Minji, Hahn, Tim, Henskens, Frans A., Holleran, Laurena, Homan, Stephanie, Homan, Philipp, Jahanshad, Neda, Janssen, Joost, Ji, Ellen, Kaiser, Stefan, Kaleda, Vasily, Kim, Minah, Kim, Woo-Sung, Kirschner, Matthias, Kochunov, Peter, Kwak, Yoo Bin, Kwon, Jun Soo, Lebedeva, Irina, Liu, Jingyu, Mitchie, Patricia, Michielse, Stijn, Mothersill, David, Mowry, Bryan, de la Foz, Víctor Ortiz-García, Pantelis, Christos, Pergola, Giulio, Piras, Fabrizio, Pomarol-Clotet, Edith, Preda, Adrian, Quidé, Yann, Rasser, Paul E., Rootes-Murdy, Kelly, Salvador, Raymond, Sangiuliano, Marina, Sarró, Salvador, Schall, Ulrich, Schmidt, André, Scott, Rodney J., Selvaggi, Pierluigi, Sim, Kang, Skoch, Antonin, Spalletta, Gianfranco, Spaniel, Filip, Thomopoulos, Sophia I., Tomecek, David, Tomyshev, Alexander S., Tordesillas-Gutiérrez, Diana, van Amelsvoort, Therese, Vázquez-Bourgon, Javier, Vecchio, Daniela, Voineskos, Aristotle, Weickert, Cynthia S., Weickert, Thomas, Thompson, Paul M., Schmaal, Lianne, van Erp, Theo G. M., Turner, Jessica, Cole, James H., Du Plessis, Stefan, Bin Kwak, Yoo, Dima, Danai, Walton, Esther, Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Neurochirurgie, RS: MHeNs - R3 - Neuroscience, MUMC+: MA Med Staf Spec Psychiatrie (9), RS: MHeNs - R2 - Mental Health, and Psychiatry 3
Subjects: Cellular and Molecular Neuroscience, Psychiatry and Mental health, SDG 3 - Good Health and Well-being, Molecular Biology
Abstract: Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study conducted by the ENIGMA Schizophrenia Working Group. The study included data from 26 cohorts worldwide, with a total of 2803 SZ patients (mean age 34.2 years; range 18–72 years; 67% male) and 2598 healthy controls (mean age 33.8 years, range 18–73 years, 55% male). Brain-predicted age was individually estimated using a model trained on independent data based on 68 measures of cortical thickness and surface area, 7 subcortical volumes, lateral ventricular volumes and total intracranial volume, all derived from T1-weighted brain magnetic resonance imaging (MRI) scans. Deviations from a healthy brain ageing trajectory were assessed by the difference between brain-predicted age and chronological age (brain-predicted age difference [brain-PAD]). On average, SZ patients showed a higher brain-PAD of +3.55 years (95% CI: 2.91, 4.19; I2 = 57.53%) compared to controls, after adjusting for age, sex and site (Cohen’s d = 0.48). Among SZ patients, brain-PAD was not associated with specific clinical characteristics (age of onset, duration of illness, symptom severity, or antipsychotic use and dose). This large-scale collaborative study suggests advanced structural brain ageing in SZ. Longitudinal studies of SZ and a range of mental and somatic health outcomes will help to further evaluate the clinical implications of increased brain-PAD and its ability to be influenced by interventions.
Published: 2023

38. Brain structural and clinical changes after first episode psychosis: Focus on cannabinoid receptor 1 polymorphisms

Author: Suárez-Pinilla, Paula, Roiz-Santiañez, Roberto, Ortiz-García de la Foz, Víctor, Guest, Paul C., Ayesa-Arriola, Rosa, Córdova-Palomera, Aldo, Tordesillas-Gutierrez, Diana, and Crespo-Facorro, Benedicto
Published: 2015
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39. Grey matter volume differences in non-affective psychosis and the effects of age of onset on grey matter volumes: A voxelwise study

Author: Tordesillas-Gutierrez, Diana, Koutsouleris, Nikolaos, Roiz-Santiañez, Roberto, Meisenzahl, Eva, Ayesa-Arriola, Rosa, Marco de Lucas, Enrique, Soriano-Mas, Carles, Suarez-Pinilla, Paula, and Crespo-Facorro, Benedicto
Published: 2015
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40. A cross-sectional and longitudinal structural magnetic resonance imaging study of the post-central gyrus in first-episode schizophrenia patients

Author: Ferro, Adele, Roiz-Santiáñez, Roberto, Ortíz-García de la Foz, Victor, Tordesillas-Gutiérrez, Diana, Ayesa-Arriola, Rosa, de La Fuente-González, Noemi, Fañanás, Lourdes, Brambilla, Paolo, and Crespo-Facorro, Benedicto
Published: 2015
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41. In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis

Author: Barth, Claudia, primary, Kelly, Sinead, additional, Nerland, Stener, additional, Jahanshad, Neda, additional, Alloza, Clara, additional, Ambrogi, Sonia, additional, Andreassen, Ole A., additional, Andreou, Dimitrios, additional, Arango, Celso, additional, Baeza, Inmaculada, additional, Banaj, Nerisa, additional, Bearden, Carrie E., additional, Berk, Michael, additional, Bohman, Hannes, additional, Castro-Fornieles, Josefina, additional, Chye, Yann, additional, Crespo-Facorro, Benedicto, additional, de la Serna, Elena, additional, Díaz-Caneja, Covadonga M., additional, Gurholt, Tiril P., additional, Hegarty, Catherine E., additional, James, Anthony, additional, Janssen, Joost, additional, Johannessen, Cecilie, additional, Jönsson, Erik G., additional, Karlsgodt, Katherine H., additional, Kochunov, Peter, additional, Lois, Noemi G., additional, Lundberg, Mathias, additional, Myhre, Anne M., additional, Pascual-Diaz, Saül, additional, Piras, Fabrizio, additional, Smelror, Runar E., additional, Spalletta, Gianfranco, additional, Stokkan, Therese S., additional, Sugranyes, Gisela, additional, Suo, Chao, additional, Thomopoulos, Sophia I., additional, Tordesillas-Gutiérrez, Diana, additional, Vecchio, Daniela, additional, Wedervang-Resell, Kirsten, additional, Wortinger, Laura A., additional, Thompson, Paul M., additional, and Agartz, Ingrid, additional
Published: 2022
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42. Pattern of long-Term weight and metabolic changes after a first-episode of psychosis: Results from a 10-years prospective follow-up of the PAFIP cohort

Author: Vázquez Bourgon, Javier, Gómez Revuelta, Marcos, Mayoral-van Son, J., Labad, J., Ortiz-García de la Foz, Víctor, Setién Suero, María Esther, Ayesa Arriola, Rosa, Tordesillas Gutiérrez, Diana, Juncal Ruiz, María, Crespo Facorro, Benedicto, and Universidad de Cantabria
Abstract: Background: People with psychosis are at higher risk of cardiovascular events, partly explained by a higher predisposition to gain weight. This has been observed in studies on individuals with a first-episode psychosis (FEP) at short and long term (mainly up to 1 year) and transversally at longer term in people with chronic schizophrenia. However, there is scarcity of data regarding longer-term (above 3-year follow-up) weight progression in FEP from longitudinal studies. The aim of this study is to evaluate the longer-term (10 years) progression of weight changes and related metabolic disturbances in people with FEP. Methods: Two hundred and nine people with FEP and 57 healthy participants (controls) were evaluated at study entry and prospectively at 10-year follow-up. Anthropometric, clinical, and sociodemographic data were collected. Results: People with FEP presented a significant and rapid increase in mean body weight during the first year of treatment, followed by less pronounced but sustained weight gain over the study period (?15.2 kg; SD 12.3 kg). This early increment in weight predicted longer-term changes, which were significantly greater than in healthy controls (?2.9 kg; SD 7.3 kg). Weight gain correlated with alterations in lipid and glycemic variables, leading to clinical repercussion such as increments in the rates of obesity and metabolic disturbances. Sex differences were observed, with women presenting higher increments in body mass index than men. Conclusions: This study confirms that the first year after initiating antipsychotic treatment is the critical one for weight gain in psychosis. Besides, it provides evidence that weight gain keep progressing even in the longer term (10 years), causing relevant metabolic disturbances.
Published: 2022

43. Virtual Ontogeny of Cortical Growth Preceding Mental Illness

Author: Patel, Yash, primary, Shin, Jean, additional, Abé, Christoph, additional, Agartz, Ingrid, additional, Alloza, Clara, additional, Alnæs, Dag, additional, Ambrogi, Sonia, additional, Antonucci, Linda A., additional, Arango, Celso, additional, Arolt, Volker, additional, Auzias, Guillaume, additional, Ayesa-Arriola, Rosa, additional, Banaj, Nerisa, additional, Banaschewski, Tobias, additional, Bandeira, Cibele, additional, Başgöze, Zeynep, additional, Cupertino, Renata Basso, additional, Bau, Claiton H.D., additional, Bauer, Jochen, additional, Baumeister, Sarah, additional, Bernardoni, Fabio, additional, Bertolino, Alessandro, additional, Bonnin, Caterina del Mar, additional, Brandeis, Daniel, additional, Brem, Silvia, additional, Bruggemann, Jason, additional, Bülow, Robin, additional, Bustillo, Juan R., additional, Calderoni, Sara, additional, Calvo, Rosa, additional, Canales-Rodríguez, Erick J., additional, Cannon, Dara M., additional, Carmona, Susanna, additional, Carr, Vaughan J., additional, Catts, Stanley V., additional, Chenji, Sneha, additional, Chew, Qian Hui, additional, Coghill, David, additional, Connolly, Colm G., additional, Conzelmann, Annette, additional, Craven, Alexander R., additional, Crespo-Facorro, Benedicto, additional, Cullen, Kathryn, additional, Dahl, Andreas, additional, Dannlowski, Udo, additional, Davey, Christopher G., additional, Deruelle, Christine, additional, Díaz-Caneja, Covadonga M., additional, Dohm, Katharina, additional, Ehrlich, Stefan, additional, Epstein, Jeffery, additional, Erwin-Grabner, Tracy, additional, Eyler, Lisa T., additional, Fedor, Jennifer, additional, Fitzgerald, Jacqueline, additional, Foran, William, additional, Ford, Judith M., additional, Fortea, Lydia, additional, Fuentes-Claramonte, Paola, additional, Fullerton, Janice, additional, Furlong, Lisa, additional, Gallagher, Louise, additional, Gao, Bingchen, additional, Gao, Si, additional, Goikolea, Jose M., additional, Gotlib, Ian, additional, Goya-Maldonado, Roberto, additional, Grabe, Hans J., additional, Green, Melissa, additional, Grevet, Eugenio H., additional, Groenewold, Nynke A., additional, Grotegerd, Dominik, additional, Gruber, Oliver, additional, Haavik, Jan, additional, Hahn, Tim, additional, Harrison, Ben J., additional, Heindel, Walter, additional, Henskens, Frans, additional, Heslenfeld, Dirk J., additional, Hilland, Eva, additional, Hoekstra, Pieter J., additional, Hohmann, Sarah, additional, Holz, Nathalie, additional, Howells, Fleur M., additional, Ipser, Jonathan C., additional, Jahanshad, Neda, additional, Jakobi, Babette, additional, Jansen, Andreas, additional, Janssen, Joost, additional, Jonassen, Rune, additional, Kaiser, Anna, additional, Kaleda, Vasiliy, additional, Karantonis, James, additional, King, Joseph A., additional, Kircher, Tilo, additional, Kochunov, Peter, additional, Koopowitz, Sheri-Michelle, additional, Landén, Mikael, additional, Landrø, Nils Inge, additional, Lawrie, Stephen, additional, Lebedeva, Irina, additional, Luna, Beatriz, additional, Lundervold, Astri J., additional, MacMaster, Frank P., additional, Maglanoc, Luigi A., additional, Mathalon, Daniel H., additional, McDonald, Colm, additional, McIntosh, Andrew, additional, Meinert, Susanne, additional, Michie, Patricia T., additional, Mitchell, Philip, additional, Moreno-Alcázar, Ana, additional, Mowry, Bryan, additional, Muratori, Filippo, additional, Nabulsi, Leila, additional, Nenadić, Igor, additional, O'Gorman Tuura, Ruth, additional, Oosterlaan, Jaap, additional, Overs, Bronwyn, additional, Pantelis, Christos, additional, Parellada, Mara, additional, Pariente, Jose C., additional, Pauli, Paul, additional, Pergola, Giulio, additional, Piarulli, Francesco Maria, additional, Picon, Felipe, additional, Piras, Fabrizio, additional, Pomarol-Clotet, Edith, additional, Pretus, Clara, additional, Quidé, Yann, additional, Radua, Joaquim, additional, Ramos-Quiroga, J. Antoni, additional, Rasser, Paul E., additional, Reif, Andreas, additional, Retico, Alessandra, additional, Roberts, Gloria, additional, Rossell, Susan, additional, Rovaris, Diego Luiz, additional, Rubia, Katya, additional, Sacchet, Matthew D., additional, Salavert, Josep, additional, Salvador, Raymond, additional, Sarró, Salvador, additional, Sawa, Akira, additional, Schall, Ulrich, additional, Scott, Rodney, additional, Selvaggi, Pierluigi, additional, Silk, Tim, additional, Sim, Kang, additional, Skoch, Antonin, additional, Spalletta, Gianfranco, additional, Spaniel, Filip, additional, Stein, Dan J., additional, Steinsträter, Olaf, additional, Stolicyn, Aleks, additional, Takayanagi, Yoichiro, additional, Tamm, Leanne, additional, Tavares, Maria, additional, Teumer, Alexander, additional, Thiel, Katharina, additional, Thomopoulos, Sophia I., additional, Tomecek, David, additional, Tomyshev, Alexander S., additional, Tordesillas-Gutiérrez, Diana, additional, Tosetti, Michela, additional, Uhlmann, Anne, additional, Van Rheenen, Tamsyn, additional, Vazquez-Bourgón, Javier, additional, Vernooij, Meike W., additional, Vieta, Eduard, additional, Vilarroya, Oscar, additional, Weickert, Cynthia, additional, Weickert, Thomas, additional, Westlye, Lars T., additional, Whalley, Heather, additional, Willinger, David, additional, Winter, Alexandra, additional, Wittfeld, Katharina, additional, Yang, Tony T., additional, Yoncheva, Yuliya, additional, Zijlmans, Jendé L., additional, Hoogman, Martine, additional, Franke, Barbara, additional, van Rooij, Daan, additional, Buitelaar, Jan, additional, Ching, Christopher R.K., additional, Andreassen, Ole A., additional, Pozzi, Elena, additional, Veltman, Dick, additional, Schmaal, Lianne, additional, van Erp, Theo G.M., additional, Turner, Jessica, additional, Castellanos, F. Xavier, additional, Pausova, Zdenka, additional, Thompson, Paul, additional, and Paus, Tomas, additional
Published: 2022
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44. Pattern of long-term weight and metabolic changes after a first episode of psychosis Results from a 10-year prospective follow-up of the PAFIP program for early intervention in psychosis cohort

Author: Universidad de Sevilla. Departamento de Psiquiatría, Instituto de Investigacion Sanitaria Valdecilla, Instituto de Salud Carlos III, Vázquez-Bourgon, Javier, Gómez-Revuelta, Marcos, Mayoral-van Son, Jaqueline, Labad, Javier, Ortiz García de la Foz, Víctor, Setién Suero, Esther, Ayesa-Arriola, Rosa, Tordesillas-Gutiérrez, Diana, Juncal-Ruiz, María, Crespo Facorro, Benedicto, Universidad de Sevilla. Departamento de Psiquiatría, Instituto de Investigacion Sanitaria Valdecilla, Instituto de Salud Carlos III, Vázquez-Bourgon, Javier, Gómez-Revuelta, Marcos, Mayoral-van Son, Jaqueline, Labad, Javier, Ortiz García de la Foz, Víctor, Setién Suero, Esther, Ayesa-Arriola, Rosa, Tordesillas-Gutiérrez, Diana, Juncal-Ruiz, María, and Crespo Facorro, Benedicto
Published: 2022

45. Subcortical volumes across the lifespan : Data from 18,605 healthy individuals aged 3–90 years

Author: Dima, Danai, Modabbernia, Amirhossein, Papachristou, Efstathios, Doucet, Gaelle E, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N, Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn I, Andersson, Micael, Andreasen, Nancy C, Andreassen, Ole A, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M, Buitelaar, Jan K, Busatto, Geraldo F, Buckner, Randy L, Calhoun, Vincent, Canales-Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Castellanos, Francisco X, Cervenka, Simon, Chaim-Avancini, Tiffany M, Ching, Christopher R K, Chubar, Victoria, Clark, Vincent P, Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A, Dale, Anders M, Davey, Christopher, de Geus, Eco J C, de Haan, Lieuwe, de Zubicaray, Greig I, den Braber, Anouk, Dickie, Erin W, Di Giorgio, Annabella, Doan, Nhat Trung, Dørum, Erlend S, Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E, Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Fuentes-Claramonte, Paola, Glahn, David C, Gotlib, Ian H, Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E, Gur, Ruben C, Harrison, Ben J, Hartman, Catharine A, Hatton, Sean N, Heinz, Andreas, Heslenfeld, Dirk J., Hibar, Derrek P, Hickie, Ian B, Ho, Beng-Choon, Hoekstra, Pieter J, Hohmann, Sarah, Holmes, Avram J, Hoogman, Martine, Hosten, Norbert, Howells, Fleur M, Hulshoff Pol, Hilleke E, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L, Jiang, Jiyang, Jönsson, Erik G, Joska, John A, Kahn, Rene, Kalnin, Andrew, Kanai, Ryota, Klein, Marieke, Klyushnik, Tatyana P, Koenders, Laura, Koops, Sanne, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lázaro, Luisa, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W J, Maingault, Sophie, Martin, Nicholas G, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, McDonald, Brenna C, McIntosh, Andrew M, McMahon, Katie L, McPhilemy, Genevieve, Menchón, José M, Medland, Sarah E, Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E, Nyberg, Lars, Oosterlaan, Jaap, de la Foz, Víctor Ortiz-García, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J, Potkin, Steven G, Radua, Joaquim, Reif, Andreas, Rinker, Daniel A, Roffman, Joshua L, Rosa, Pedro G P, Sacchet, Matthew D, Sachdev, Perminder S, Salvador, Raymond, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D, Saykin, Andrew J, Serpa, Mauricio H, Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W, Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J, Strike, Lachlan T, Swagerman, Suzanne C, Tamnes, Christian K, Temmingh, Henk S, Thomopoulos, Sophia I, Tomyshev, Alexander S, Tordesillas-Gutiérrez, Diana, Trollor, Julian N, Turner, Jessica A, Uhlmann, Anne, van den Heuvel, Odile A, van den Meer, Dennis, van der Wee, Nic J A, van Haren, Neeltje E M, Van't Ent, Dennis, van Erp, Theo G M, Veer, Ilya M, Veltman, Dick J, Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H, Weber, Bernd, Wen, Wei, West, John D, Westlye, Lars T, Whalley, Heather, Wierenga, Lara M, Williams, Steven C R, Wittfeld, Katharina, Wolf, Daniel H, Worker, Amanda, Wright, Margaret J, Yang, Kun, Yoncheva, Yulyia, Zanetti, Marcus V, Ziegler, Georg C, Thompson, Paul M, Frangou, Sophia, other, and, Dima, Danai, Modabbernia, Amirhossein, Papachristou, Efstathios, Doucet, Gaelle E, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N, Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn I, Andersson, Micael, Andreasen, Nancy C, Andreassen, Ole A, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M, Buitelaar, Jan K, Busatto, Geraldo F, Buckner, Randy L, Calhoun, Vincent, Canales-Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Castellanos, Francisco X, Cervenka, Simon, Chaim-Avancini, Tiffany M, Ching, Christopher R K, Chubar, Victoria, Clark, Vincent P, Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A, Dale, Anders M, Davey, Christopher, de Geus, Eco J C, de Haan, Lieuwe, de Zubicaray, Greig I, den Braber, Anouk, Dickie, Erin W, Di Giorgio, Annabella, Doan, Nhat Trung, Dørum, Erlend S, Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E, Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Fuentes-Claramonte, Paola, Glahn, David C, Gotlib, Ian H, Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E, Gur, Ruben C, Harrison, Ben J, Hartman, Catharine A, Hatton, Sean N, Heinz, Andreas, Heslenfeld, Dirk J., Hibar, Derrek P, Hickie, Ian B, Ho, Beng-Choon, Hoekstra, Pieter J, Hohmann, Sarah, Holmes, Avram J, Hoogman, Martine, Hosten, Norbert, Howells, Fleur M, Hulshoff Pol, Hilleke E, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L, Jiang, Jiyang, Jönsson, Erik G, Joska, John A, Kahn, Rene, Kalnin, Andrew, Kanai, Ryota, Klein, Marieke, Klyushnik, Tatyana P, Koenders, Laura, Koops, Sanne, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lázaro, Luisa, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W J, Maingault, Sophie, Martin, Nicholas G, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, McDonald, Brenna C, McIntosh, Andrew M, McMahon, Katie L, McPhilemy, Genevieve, Menchón, José M, Medland, Sarah E, Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E, Nyberg, Lars, Oosterlaan, Jaap, de la Foz, Víctor Ortiz-García, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J, Potkin, Steven G, Radua, Joaquim, Reif, Andreas, Rinker, Daniel A, Roffman, Joshua L, Rosa, Pedro G P, Sacchet, Matthew D, Sachdev, Perminder S, Salvador, Raymond, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D, Saykin, Andrew J, Serpa, Mauricio H, Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W, Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J, Strike, Lachlan T, Swagerman, Suzanne C, Tamnes, Christian K, Temmingh, Henk S, Thomopoulos, Sophia I, Tomyshev, Alexander S, Tordesillas-Gutiérrez, Diana, Trollor, Julian N, Turner, Jessica A, Uhlmann, Anne, van den Heuvel, Odile A, van den Meer, Dennis, van der Wee, Nic J A, van Haren, Neeltje E M, Van't Ent, Dennis, van Erp, Theo G M, Veer, Ilya M, Veltman, Dick J, Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H, Weber, Bernd, Wen, Wei, West, John D, Westlye, Lars T, Whalley, Heather, Wierenga, Lara M, Williams, Steven C R, Wittfeld, Katharina, Wolf, Daniel H, Worker, Amanda, Wright, Margaret J, Yang, Kun, Yoncheva, Yulyia, Zanetti, Marcus V, Ziegler, Georg C, Thompson, Paul M, Frangou, Sophia, and other, and
Abstract: Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
Published: 2022

46. Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs

Author: Sønderby, Ida E., Ching, Christopher R.K., Thomopoulos, Sophia I., van der Meer, Dennis, Sun, Daqiang, Villalon-Reina, Julio E., Agartz, Ingrid, Amunts, Katrin, Arango, Celso, Armstrong, Nicola J., Ayesa-Arriola, Rosa, Bakker, Geor, Bassett, Anne S., Boomsma, Dorret I., Bülow, Robin, Butcher, Nancy J., Calhoun, Vince D., Caspers, Svenja, Chow, Eva W.C., Cichon, Sven, Ciufolini, Simone, Craig, Michael C., Crespo-Facorro, Benedicto, Cunningham, Adam C., Dale, Anders M., Dazzan, Paola, de Zubicaray, Greig I., Djurovic, Srdjan, Doherty, Joanne L., Donohoe, Gary, Draganski, Bogdan, Durdle, Courtney A., Ehrlich, Stefan, Emanuel, Beverly S., Espeseth, Thomas, Fisher, Simon E., Ge, Tian, Glahn, David C., Grabe, Hans J., Gur, Raquel E., Gutman, Boris A., Haavik, Jan, Håberg, Asta K., Hansen, Laura A., Hashimoto, Ryota, Hibar, Derrek P., Holmes, Avram J., Hottenga, Jouke Jan, Hulshoff Pol, Hilleke E., Jalbrzikowski, Maria, Knowles, Emma E.M., Kushan, Leila, Linden, David E.J., Liu, Jingyu, Lundervold, Astri J., Martin-Brevet, Sandra, Martínez, Kenia, Mather, Karen A., Mathias, Samuel R., McDonald-McGinn, Donna M., McRae, Allan F., Medland, Sarah E., Moberget, Torgeir, Modenato, Claudia, Monereo Sánchez, Jennifer, Moreau, Clara A., Mühleisen, Thomas W., Paus, Tomas, Pausova, Zdenka, Prieto, Carlos, Ragothaman, Anjanibhargavi, Reinbold, Céline S., Reis Marques, Tiago, Repetto, Gabriela M., Reymond, Alexandre, Roalf, David R., Rodriguez-Herreros, Borja, Rucker, James J., Sachdev, Perminder S., Schmitt, James E., Schofield, Peter R., Silva, Ana I., Stefansson, Hreinn, Stein, Dan J., Tamnes, Christian K., Tordesillas-Gutiérrez, Diana, Ulfarsson, Magnus O., Vajdi, Ariana, van 't Ent, Dennis, van den Bree, Marianne B.M., Vassos, Evangelos, Vázquez-Bourgon, Javier, Vila-Rodriguez, Fidel, Walters, G. Bragi, Wen, Wei, Westlye, Lars T., Wittfeld, Katharina, Zackai, Elaine H., Stefánsson, Kári, Jacquemont, Sebastien, Thompson, Paul M., Bearden, Carrie E., Andreassen, Ole A., other, and, Sønderby, Ida E., Ching, Christopher R.K., Thomopoulos, Sophia I., van der Meer, Dennis, Sun, Daqiang, Villalon-Reina, Julio E., Agartz, Ingrid, Amunts, Katrin, Arango, Celso, Armstrong, Nicola J., Ayesa-Arriola, Rosa, Bakker, Geor, Bassett, Anne S., Boomsma, Dorret I., Bülow, Robin, Butcher, Nancy J., Calhoun, Vince D., Caspers, Svenja, Chow, Eva W.C., Cichon, Sven, Ciufolini, Simone, Craig, Michael C., Crespo-Facorro, Benedicto, Cunningham, Adam C., Dale, Anders M., Dazzan, Paola, de Zubicaray, Greig I., Djurovic, Srdjan, Doherty, Joanne L., Donohoe, Gary, Draganski, Bogdan, Durdle, Courtney A., Ehrlich, Stefan, Emanuel, Beverly S., Espeseth, Thomas, Fisher, Simon E., Ge, Tian, Glahn, David C., Grabe, Hans J., Gur, Raquel E., Gutman, Boris A., Haavik, Jan, Håberg, Asta K., Hansen, Laura A., Hashimoto, Ryota, Hibar, Derrek P., Holmes, Avram J., Hottenga, Jouke Jan, Hulshoff Pol, Hilleke E., Jalbrzikowski, Maria, Knowles, Emma E.M., Kushan, Leila, Linden, David E.J., Liu, Jingyu, Lundervold, Astri J., Martin-Brevet, Sandra, Martínez, Kenia, Mather, Karen A., Mathias, Samuel R., McDonald-McGinn, Donna M., McRae, Allan F., Medland, Sarah E., Moberget, Torgeir, Modenato, Claudia, Monereo Sánchez, Jennifer, Moreau, Clara A., Mühleisen, Thomas W., Paus, Tomas, Pausova, Zdenka, Prieto, Carlos, Ragothaman, Anjanibhargavi, Reinbold, Céline S., Reis Marques, Tiago, Repetto, Gabriela M., Reymond, Alexandre, Roalf, David R., Rodriguez-Herreros, Borja, Rucker, James J., Sachdev, Perminder S., Schmitt, James E., Schofield, Peter R., Silva, Ana I., Stefansson, Hreinn, Stein, Dan J., Tamnes, Christian K., Tordesillas-Gutiérrez, Diana, Ulfarsson, Magnus O., Vajdi, Ariana, van 't Ent, Dennis, van den Bree, Marianne B.M., Vassos, Evangelos, Vázquez-Bourgon, Javier, Vila-Rodriguez, Fidel, Walters, G. Bragi, Wen, Wei, Westlye, Lars T., Wittfeld, Katharina, Zackai, Elaine H., Stefánsson, Kári, Jacquemont, Sebastien, Thompson, Paul M., Bearden, Carrie E., Andreassen, Ole A., and other, and
Abstract: The Enhancing NeuroImaging Genetics through Meta-Analysis copy number variant (ENIGMA-CNV) and 22q11.2 Deletion Syndrome Working Groups (22q-ENIGMA WGs) were created to gain insight into the involvement of genetic factors in human brain development and related cognitive, psychiatric and behavioral manifestations. To that end, the ENIGMA-CNV WG has collated CNV and magnetic resonance imaging (MRI) data from ~49,000 individuals across 38 global research sites, yielding one of the largest studies to date on the effects of CNVs on brain structures in the general population. The 22q-ENIGMA WG includes 12 international research centers that assessed over 533 individuals with a confirmed 22q11.2 deletion syndrome, 40 with 22q11.2 duplications, and 333 typically developing controls, creating the largest-ever 22q11.2 CNV neuroimaging data set. In this review, we outline the ENIGMA infrastructure and procedures for multi-site analysis of CNVs and MRI data. So far, ENIGMA has identified effects of the 22q11.2, 16p11.2 distal, 15q11.2, and 1q21.1 distal CNVs on subcortical and cortical brain structures. Each CNV is associated with differences in cognitive, neurodevelopmental and neuropsychiatric traits, with characteristic patterns of brain structural abnormalities. Evidence of gene-dosage effects on distinct brain regions also emerged, providing further insight into genotype–phenotype relationships. Taken together, these results offer a more comprehensive picture of molecular mechanisms involved in typical and atypical brain development. This “genotype-first” approach also contributes to our understanding of the etiopathogenesis of brain disorders. Finally, we outline future directions to better understand effects of CNVs on brain structure and behavior.
Published: 2022

47. Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years

Author: Frangou, Sophia, Modabbernia, Amirhossein, Williams, Steven C R, Papachristou, Efstathios, Doucet, Gaelle E, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N, Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn I, Andersson, Micael, Andreasen, Nancy C, Andreassen, Ole A, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M, Buitelaar, Jan K, Busatto, Geraldo F, Buckner, Randy L, Calhoun, Vincent, Canales-Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Castellanos, Francisco X, Cervenka, Simon, Chaim-Avancini, Tiffany M, Ching, Christopher R K, Chubar, Victoria, Clark, Vincent P, Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A, Dale, Anders M, Davey, Christopher, de Geus, Eco J C, de Haan, Lieuwe, de Zubicaray, Greig I, den Braber, Anouk, Dickie, Erin W, Di Giorgio, Annabella, Doan, Nhat Trung, Dørum, Erlend S, Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E, Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Fuentes-Claramonte, Paola, Glahn, David C, Gotlib, Ian H, Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E, Gur, Ruben C, Harrison, Ben J, Hartman, Catharine A, Hatton, Sean N, Heinz, Andreas, Heslenfeld, Dirk J, Hibar, Derrek P, Hickie, Ian B, Ho, Beng-Choon, Hoekstra, Pieter J, Hohmann, Sarah, Holmes, Avram J, Hoogman, Martine, Hosten, Norbert, Howells, Fleur M, Hulshoff Pol, Hilleke E, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L, Jiang, Jiyang, Jönsson, Erik G, Joska, John A, Kahn, Rene, Kalnin, Andrew, Kanai, Ryota, Klein, Marieke, Klyushnik, Tatyana P, Koenders, Laura, Koops, Sanne, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lázaro, Luisa, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W J, Maingault, Sophie, Martin, Nicholas G, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, McDonald, Brenna C, McIntosh, Andrew M, McMahon, Katie L, McPhilemy, Genevieve, Menchón, José M, Medland, Sarah E, Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E, Nyberg, Lars, Oosterlaan, Jaap, de la Foz, Víctor Ortiz-García, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J, Potkin, Steven G, Radua, Joaquim, Reif, Andreas, Rinker, Daniel A, Roffman, Joshua L, Rosa, Pedro G P, Sacchet, Matthew D, Sachdev, Perminder S, Salvador, Raymond, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D, Saykin, Andrew J, Serpa, Mauricio H, Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W, Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J, Strike, Lachlan T, Swagerman, Suzanne C, Tamnes, Christian K, Temmingh, Henk S, Thomopoulos, Sophia I, Tomyshev, Alexander S, Tordesillas-Gutiérrez, Diana, Trollor, Julian N, Turner, Jessica A, Uhlmann, Anne, van den Heuvel, Odile A, van den Meer, Dennis, van der Wee, Nic J A, van Haren, Neeltje E M, van 't Ent, Dennis, van Erp, Theo G M, Veer, Ilya M, Veltman, Dick J, Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H, Weber, Bernd, Wen, Wei, West, John D, Westlye, Lars T, Whalley, Heather, Wierenga, Lara M, Wittfeld, Katharina, Wolf, Daniel H, Worker, Amanda, Wright, Margaret J, Yang, Kun, Yoncheva, Yulyia, Zanetti, Marcus V, Ziegler, Georg C, Thompson, Paul M, Dima, Danai, other, and, Frangou, Sophia, Modabbernia, Amirhossein, Williams, Steven C R, Papachristou, Efstathios, Doucet, Gaelle E, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N, Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn I, Andersson, Micael, Andreasen, Nancy C, Andreassen, Ole A, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M, Buitelaar, Jan K, Busatto, Geraldo F, Buckner, Randy L, Calhoun, Vincent, Canales-Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Castellanos, Francisco X, Cervenka, Simon, Chaim-Avancini, Tiffany M, Ching, Christopher R K, Chubar, Victoria, Clark, Vincent P, Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A, Dale, Anders M, Davey, Christopher, de Geus, Eco J C, de Haan, Lieuwe, de Zubicaray, Greig I, den Braber, Anouk, Dickie, Erin W, Di Giorgio, Annabella, Doan, Nhat Trung, Dørum, Erlend S, Ehrlich, Stefan, Erk, Susanne, Espeseth, Thomas, Fatouros-Bergman, Helena, Fisher, Simon E, Fouche, Jean-Paul, Franke, Barbara, Frodl, Thomas, Fuentes-Claramonte, Paola, Glahn, David C, Gotlib, Ian H, Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E, Gur, Ruben C, Harrison, Ben J, Hartman, Catharine A, Hatton, Sean N, Heinz, Andreas, Heslenfeld, Dirk J, Hibar, Derrek P, Hickie, Ian B, Ho, Beng-Choon, Hoekstra, Pieter J, Hohmann, Sarah, Holmes, Avram J, Hoogman, Martine, Hosten, Norbert, Howells, Fleur M, Hulshoff Pol, Hilleke E, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L, Jiang, Jiyang, Jönsson, Erik G, Joska, John A, Kahn, Rene, Kalnin, Andrew, Kanai, Ryota, Klein, Marieke, Klyushnik, Tatyana P, Koenders, Laura, Koops, Sanne, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lázaro, Luisa, Lebedeva, Irina, Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W J, Maingault, Sophie, Martin, Nicholas G, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, McDonald, Brenna C, McIntosh, Andrew M, McMahon, Katie L, McPhilemy, Genevieve, Menchón, José M, Medland, Sarah E, Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Nakao, Tomohiro, Nordvik, Jan E, Nyberg, Lars, Oosterlaan, Jaap, de la Foz, Víctor Ortiz-García, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J, Potkin, Steven G, Radua, Joaquim, Reif, Andreas, Rinker, Daniel A, Roffman, Joshua L, Rosa, Pedro G P, Sacchet, Matthew D, Sachdev, Perminder S, Salvador, Raymond, Sánchez-Juan, Pascual, Sarró, Salvador, Satterthwaite, Theodore D, Saykin, Andrew J, Serpa, Mauricio H, Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Smoller, Jordan W, Sommer, Iris, Soriano-Mas, Carles, Stein, Dan J, Strike, Lachlan T, Swagerman, Suzanne C, Tamnes, Christian K, Temmingh, Henk S, Thomopoulos, Sophia I, Tomyshev, Alexander S, Tordesillas-Gutiérrez, Diana, Trollor, Julian N, Turner, Jessica A, Uhlmann, Anne, van den Heuvel, Odile A, van den Meer, Dennis, van der Wee, Nic J A, van Haren, Neeltje E M, van 't Ent, Dennis, van Erp, Theo G M, Veer, Ilya M, Veltman, Dick J, Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Walton, Esther, Wang, Lei, Wang, Yang, Wassink, Thomas H, Weber, Bernd, Wen, Wei, West, John D, Westlye, Lars T, Whalley, Heather, Wierenga, Lara M, Wittfeld, Katharina, Wolf, Daniel H, Worker, Amanda, Wright, Margaret J, Yang, Kun, Yoncheva, Yulyia, Zanetti, Marcus V, Ziegler, Georg C, Thompson, Paul M, Dima, Danai, and other, and
Abstract: Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
Published: 2022

48. A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium

Author: Universidad de Sevilla. Departamento de Psiquiatría, Gutman, Boris A., Van Erp, Theo G.M, Tordesillas Gutiérrez, Diana, Crespo Facorro, Benedicto, Setién Suero, Esther, Wang, Lei, Universidad de Sevilla. Departamento de Psiquiatría, Gutman, Boris A., Van Erp, Theo G.M, Tordesillas Gutiérrez, Diana, Crespo Facorro, Benedicto, Setién Suero, Esther, and Wang, Lei
Abstract: Schizophrenia is associated with widespread alterations in subcortical brain structure.While analytic methods have enabled more detailed morphometric characterization,findings are often equivocal. In this meta-analysis, we employed the harmonizedENIGMA shape analysis protocols to collaboratively investigate subcortical brainstructure shape differences between individuals with schizophrenia and healthy con-trol participants. The study analyzed data from 2,833 individuals with schizophreniaand 3,929 healthy control participants contributed by 21 worldwide research groupsparticipating in the ENIGMA Schizophrenia Working Group. Harmonized shape analy-sis protocols were applied to each site's data independently for bilateral hippocam-pus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained fromT1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens,and thalamus in individuals with schizophrenia compared with control participants,more-convex-than-concave shape differences in the putamen and pallidum, and bothconcave and convex shape differences in the caudate. Patterns of exaggerated asym-metry were observed across the hippocampus, amygdala, and thalamus in individualswith schizophrenia compared to control participants, while diminished asymmetryencompassed ventral striatum and ventral and dorsal thalamus. Our analyses also rev-ealed that higher chlorpromazine dose equivalents and increased positive symptomlevels were associated with patterns of contiguous convex shape differences acrossmultiple subcortical structures. Findings from our shape meta-analysis suggest thatcommon neurobiological mechanisms may contribute to gray matter reduction acrossmultiple subcortical regions, thus enhancing our understanding of the nature of net-work disorganization in schizophrenia.
Published: 2022

49. Supplemental material for Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium

Author: Velzen, Laura S. van, Crespo-Facorro, Benedicto, Tordesillas-Gutiérrez, Diana, ENIGMA Suicidal Thoughts and Behaviours Consortium, Velzen, Laura S. van, Crespo-Facorro, Benedicto, Tordesillas-Gutiérrez, Diana, and ENIGMA Suicidal Thoughts and Behaviours Consortium
Published: 2022

50. Supplemental material for Obesity and brain structure in schizophrenia – ENIGMA study in 3021 individuals

Author: McWhinney, Sean R., Crespo-Facorro, Benedicto, Tordesillas-Gutiérrez, Diana, Hajek, Tomas, McWhinney, Sean R., Crespo-Facorro, Benedicto, Tordesillas-Gutiérrez, Diana, and Hajek, Tomas
Published: 2022

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