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Brain ageing in schizophrenia:evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium
- Source :
- ENIGMA Schizophrenia Consortium 2023, ' Brain ageing in schizophrenia : evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium ', Molecular Psychiatry, vol. 28, no. 3, pp. 1201-1209 . https://doi.org/10.1038/s41380-022-01897-w, Molecular Psychiatry, 28(3), 1201-1209. Nature Publishing Group, 2023, ' Brain ageing in schizophrenia : evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium ', Molecular Psychiatry, vol. 28, no. 3, pp. 1201-1209 . https://doi.org/10.1038/s41380-022-01897-w, Molecular Psychiatry, 28, 1201-1209. Nature Publishing Group, Molecular Psychiatry
- Publication Year :
- 2023
-
Abstract
- Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study conducted by the ENIGMA Schizophrenia Working Group. The study included data from 26 cohorts worldwide, with a total of 2803 SZ patients (mean age 34.2 years; range 18–72 years; 67% male) and 2598 healthy controls (mean age 33.8 years, range 18–73 years, 55% male). Brain-predicted age was individually estimated using a model trained on independent data based on 68 measures of cortical thickness and surface area, 7 subcortical volumes, lateral ventricular volumes and total intracranial volume, all derived from T1-weighted brain magnetic resonance imaging (MRI) scans. Deviations from a healthy brain ageing trajectory were assessed by the difference between brain-predicted age and chronological age (brain-predicted age difference [brain-PAD]). On average, SZ patients showed a higher brain-PAD of +3.55 years (95% CI: 2.91, 4.19; I2 = 57.53%) compared to controls, after adjusting for age, sex and site (Cohen’s d = 0.48). Among SZ patients, brain-PAD was not associated with specific clinical characteristics (age of onset, duration of illness, symptom severity, or antipsychotic use and dose). This large-scale collaborative study suggests advanced structural brain ageing in SZ. Longitudinal studies of SZ and a range of mental and somatic health outcomes will help to further evaluate the clinical implications of increased brain-PAD and its ability to be influenced by interventions.
Details
- Language :
- English
- ISSN :
- 13594184
- Database :
- OpenAIRE
- Journal :
- ENIGMA Schizophrenia Consortium 2023, ' Brain ageing in schizophrenia : evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium ', Molecular Psychiatry, vol. 28, no. 3, pp. 1201-1209 . https://doi.org/10.1038/s41380-022-01897-w, Molecular Psychiatry, 28(3), 1201-1209. Nature Publishing Group, 2023, ' Brain ageing in schizophrenia : evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium ', Molecular Psychiatry, vol. 28, no. 3, pp. 1201-1209 . https://doi.org/10.1038/s41380-022-01897-w, Molecular Psychiatry, 28, 1201-1209. Nature Publishing Group, Molecular Psychiatry
- Accession number :
- edsair.doi.dedup.....58ab7ee17a050aa802ff6e3ca145aae0