135 results on '"Tomoko S. Kato"'
Search Results
2. Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside
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Hiroyuki Yamakawa, Tomoko S. Kato, Jaeduk Yoshimura Noh, Shinsuke Yuasa, Akio Kawamura, Keiichi Fukuda, and Yoshiyasu Aizawa
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thyroid hormone ,hyperthyroidism ,hypothyroidism ,cardiovascular disease ,genomic pathways ,non-genomic pathways ,Physiology ,QP1-981 - Abstract
Thyroid hormones (THs) are synthesized in the thyroid gland, and they circulate in the blood to regulate cells, tissues, and organs in the body. In particular, they exert several effects on the cardiovascular system. It is well known that THs raise the heart rate and cardiac contractility, improve the systolic and diastolic function of the heart, and decrease systemic vascular resistance. In the past 30 years, some researchers have studied the molecular pathways that mediate the role of TH in the cardiovascular system, to better understand its mechanisms of action. Two types of mechanisms, which are genomic and non-genomic pathways, underlie the effects of THs on cardiomyocytes. In this review, we summarize the current knowledge of the action of THs in the cardiac function, the clinical manifestation and parameters of their hemodynamics, and treatment principles for patients with hyperthyroid- or hypothyroid-associated heart disease. We also describe the cardiovascular drugs that induce thyroid dysfunction and explain the mechanism underlying the thyroid toxicity of amiodarone, which is considered the most effective antiarrhythmic agent. Finally, we discuss the recent reports on the involvement of thyroid hormones in the regulation of myocardial regeneration and metabolism in the adult heart.
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- 2021
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3. Normalization of Pulmonary Hypertension by the Use of Left Ventricular Assist Device in Patients with End-stage Heart Failure: A Possible Contribution to Donor Pool Expansion in Lung Transplantation
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Hirokazu Akashi, Tomoko S. Kato, Kazuhiko Hashimura, Masafumi Kitakaze, Khurram Shahzad, Maryjane Farr, Mancini Donna, Hiroo Takayama, Yoshifumi Naka, Taira Yamamoto, and Atsushi Amano
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left ventricular assist device ,lung transplantation ,pulmonary vascular resistance ,Geriatrics ,RC952-954.6 - Abstract
Heart transplantation alone has been recognized to be contraindicated when pulmonary hypertension (PH) and elevated pulmonary vascular resistance (PVR) are irreversible, irrespective of any medical intervention by the use of inotropic agents or pulmonary vasodilators, because such patients are at an increased risk of post-transplantation right ventricular failure and mortality. Therefore, end-stage heart failure patients with concomitant fixed PH and irreversibly high PVR are considered to be heart–lung transplant candidates. Recently, left ventricular assist device (LVAD) therapy has been reported to normalize PVR through persistent unloading of the left ventricle, even in patients with medically refractory PH. Therefore, LVAD therapy could make such patients suitable for “heart-only” transplants, which contributes to appropriate donor lung allocation for lung-only candidates. We review the literature regarding LVAD use for secondary PH and present a case with end-stage heart failure that could avoid a heart–lung transplant owing to LVAD therapy.
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- 2014
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4. Prothrombin Complex Concentrate for Rapid Reversal of Warfarin-induced Anticoagulation and Intracerebral Hemorrhage in Patients Supported by a Left Ventricular Assist Device
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Ayako Takahashi, Tomoko S. Kato, Noboru Oda, Kazuo Komamura, Hideaki Kanzaki, Masaki Asakura, Kazuhiko Hashimura, Kazuo Niwaya, Toshiaki Funatsu, Takeshi Nakatani, Junjiro Kobayashi, Soichiro Kitamura, Toshiaki Shishido, Shigeki Miyata, Jun C. Takahashi, Koji Iihara, and Masafumi Kitakaze
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anticoagulants ,cerebral hemorrhage ,heart-assist devices ,heart transplantation ,prothrombin complex concentrate ,Geriatrics ,RC952-954.6 - Abstract
Background: Intracerebral hemorrhage (ICH) is one of the most serious complications in patients supported by a left ventricular assist device (LVAD). We evaluate the efficacy of prothrombin complex concentrate (PCC) for rapid reversal of warfarin-induced anticoagulation in this population. Methods: A total of 38 consecutive ICH events in patients supported by an LVAD between 1996 and 2007 were retrospectively reviewed. Fourteen ICH events were treated with fresh frozen plasma (FFP) (Group FFP) and 24 ICH events were treated with PCC (Group PCC). The efficacy and outcome of PCC administration versus FFP were evaluated. Results: The proportion of patients surviving after an ICH event was significantly smaller in Group FFP than Group PCC (35.7% vs. 75.0%, p < 0.05). None of the patients in Group FFP were able to undergo heart transplantation, whereas 21.4% patients in Group PCC successfully underwent heart transplantation. Conclusion: Patients on LVAD are in need for intensified anticoagulation and are at high risk of ICH; therefore, adequate use of PCC in the event of ICH could be of importance for survival and allow subsequent heart transplantation.
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- 2010
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5. How to preserve information equity for COVID‐19 vaccination among severely immunocompromised populations: Challenges among heart transplant recipients in Japan
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Tomoko S. Kato, Harumi Gomi, Howard J. Eisen, and Sharon A. Hunt
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Immunocompromised Host ,Transplantation ,COVID-19 Vaccines ,Japan ,Vaccination ,COVID-19 ,Heart Transplantation ,Humans ,Transplant Recipients - Published
- 2022
6. Knock knock, who's there?: intracardiac giant thrombi
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Tomoko S Kato, Daiki Hirayama, and Susumu Manabe
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Cardiology and Cardiovascular Medicine - Published
- 2023
7. Successful Leadless Pacemaker Implantation in an Elderly Patient With Dextrocardia and Situs Inversus
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Yuto Monma, Akihiro Yoshizawa, Tomoko S. Kato, Yoshiyasu Aizawa, Takashi Nakayama, Tomoko Ichiki, Akio Kawamura, Shigenobu Inami, and Yoshihide Fujimoto
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Bradycardia ,Dextrocardia ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Cardiology ,General Engineering ,situs inversus ,medicine.disease ,Surgery ,Temporary Pacemaker ,Pacemaker implantation ,Situs inversus ,micra ,atrio-ventricular block ,otorhinolaryngologic diseases ,medicine ,medicine.symptom ,Chest radiograph ,Elderly patient ,business ,leadless pacemaker ,dextrocardia ,Cardiac catheterization - Abstract
Leadless pacemaker is indicated in patients with symptomatic bradycardia as an alternative therapy when transvenous pacemaker implantation is considered difficult or at high risk. The experience of implanting leadless pacemaker in patients with dextrocardia and situs inversus is limited. A 94-year-old male was transferred to our hospital due to advanced atrio-ventricular block with episode of syncope. Chest radiograph and computed tomography revealed dextrocardia with situs inversus. Emergency cardiac catheterization was performed and a temporary pacemaker was inserted, but the patient removed it due to delirium. So, a leadless pacemaker was implanted to him. Shorter time of bed-rest after the implantation and shorter hospital stay would be beneficial of implanting a leadless pacemaker. Precise anatomical evaluation would be important to perform implantation efficiently and safely.
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- 2021
8. An Autopsy Case of Cardiac Amyloidosis with Heterogeneous Deposition of Amyloid Protein: A Possible Mechanism for Relative Apical Sparing of Longitudinal Strain
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Tomoko S. Kato, Tetsuo Ushiku, Naoko Sawada, Issei Komuro, Masao Daimon, Hiroyuki Abe, and Hiroyuki Morita
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Pathology ,medicine.medical_specialty ,Amyloidosis Autopsy ,Longitudinal strain ,Mechanism (biology) ,business.industry ,General Medicine ,Autopsy case ,Cardiac amyloidosis ,Echocardiography ,medicine ,business ,Deposition (chemistry) ,ComputingMethodologies_COMPUTERGRAPHICS - Abstract
Graphical abstract, Highlights • Relative apical sparing of LS is useful for diagnosis of CA. • Amyloid protein was greater in the basal than apical wall in a patient with ATTR-CA. • Differences in amyloid load may contribute to the apical sparing phenomenon.
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- 2019
9. Are there gender differences in the association between body mass index and left ventricular diastolic function? A clinical observational study in the Japanese general population
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Megumi Hirokawa, Yuriko Yoshida, Jumpei Ishiwata, Tomohiro Shinozaki, Yutaka Yatomi, Masao Daimon, Tomoko S. Kato, Yoshiko Mizuno, Koki Nakanishi, Naoko Sawada, Tomoko Nakao, Issei Komuro, Koichi Kimura, Hiroyuki Morita, and Kayoko Kozuma
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Male ,medicine.medical_specialty ,Population ,Diastole ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,Body Mass Index ,03 medical and health sciences ,Ventricular Dysfunction, Left ,0302 clinical medicine ,Japan ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Risk factor ,education ,Aged ,Heart Failure ,education.field_of_study ,Sex Characteristics ,business.industry ,Stroke Volume ,medicine.disease ,Obesity ,Heart failure ,Cardiology ,Observational study ,Female ,Cardiology and Cardiovascular Medicine ,Heart failure with preserved ejection fraction ,business ,Body mass index - Abstract
Background Increased body mass index (BMI) is a major risk factor for heart failure with preserved ejection fraction (HFpEF), and HFpEF is more prevalent in elderly females than males. We hypothesized that there may be gender differences in the association between BMI and echocardiographic left ventricular (LV) diastolic parameters. Methods We enrolled 456 subjects (243 males) without overt cardiac diseases, all of whom underwent a health checkup. Early (E) and late (A) diastolic transmitral flow velocity, early diastolic mitral annular velocity (e'), and left atrial (LA) volume index were measured by echocardiography to assess LV diastolic function. To examine gender differences in the association between BMI and LV diastolic function, we analyzed the interaction effects of gender on the association between BMI and echocardiographic LV diastolic parameters. Results Although there were significant gender differences in the association between BMI and E/A and e' in the crude model (interaction effect 0.037 and 0.173, respectively; P = .006 and .022, respectively), these differences were not statistically significant after adjustment for factors related to LV diastolic function. On the other hand, there were significant associations between BMI and LV diastolic parameters in each gender, even after adjustment. Conclusions Our findings suggest there is no gender difference in the association between BMI and echocardiographic LV diastolic parameters. However, the association between BMI and LV diastolic parameters was significant in both genders. Controlling body weight might be beneficial for both women and men to prevent progression of LV diastolic dysfunction and development of HFpEF.
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- 2020
10. Echocardiographic assessment of right ventricular function in routine practice: Which parameters are useful to predict one-year outcome in advanced heart failure patients with dilated cardiomyopathy?
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Tomoko Nakao, Tomoko S. Kato, Koichi Kimura, Masafumi Watanabe, Masao Daimon, Yutaka Yatomi, Seitetsu L. Lee, Takayuki Kawata, Issei Komuro, and Megumi Hirokawa
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Adult ,Cardiomyopathy, Dilated ,Male ,Inotrope ,medicine.medical_specialty ,Systole ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Natriuretic Peptide, Brain ,Heart rate ,medicine ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,Heart Failure ,Univariate analysis ,Ejection fraction ,business.industry ,Dilated cardiomyopathy ,Middle Aged ,Prognosis ,medicine.disease ,Brain natriuretic peptide ,Echocardiography, Doppler ,Blood pressure ,ROC Curve ,Heart failure ,Ventricular Function, Right ,cardiovascular system ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Right ventricular (RV) function has recently gained attention as a prognostic predictor of outcome even in patients who have left-sided heart failure. Since several conventional echocardiographic parameters of RV systolic function have been proposed, our aim was to determine if any of these parameters (tricuspid annular plane systolic excursion: TAPSE, tissue Doppler derived systolic tricuspid annular motion velocity: S', fractional area change: FAC) are associated with outcome in advanced heart failure patients with dilated cardiomyopathy (DCM).We retrospectively enrolled 68 DCM patients, who were New York Heart Association (NYHA) Class III or IV and had a left ventricular (LV) ejection fraction35%. All patients were undergoing evaluation for heart transplantation or management of heart failure. Primary outcomes were defined as LV assist device implantation or cardiac death within one year.Thirty-nine events occurred (5 deaths, 32 LV assist devices implanted). Univariate analysis showed that age, systolic blood pressure, heart rate, NYHA functional class IV, plasma brain natriuretic peptide concentration, intravenous inotrope use, left atrial volume index, and FAC were associated with outcome, whereas TAPSE and S' were not. Receiver-operating characteristic curve analysis showed that the optimal FAC cut-off value to identify patients with an event was26.7% (area under the curve=0.74). The event-free rate determined by Kaplan-Meier analysis was significantly higher in patients with FAC≥26.7% than in those with FAC26.7% (log-lank, p=0.0003). Moreover, the addition of FAC26.7% improved the prognostic utility of a model containing clinical variables and conventional echocardiographic indexes.FAC may provide better prognostic information than TAPSE or S' in advanced heart failure patients with DCM.
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- 2017
11. Periodontitis and bone metabolism in patients with advanced heart failure and after heart transplantation
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Peter J. Kennel, Christina Wu, Tomoko S. Kato, Kristina Rodriguez Salaverry, John T. Grbic, Ulrike Schulze-Späte, Jaime Chang, P. Christian Schulze, Donna Mancini, Meaghan Jones, Danielle Brunjes, Tse-Hwei Choo, and Iman Mizani
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Periodontitis ,Heart transplantation ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Bleeding on probing ,030206 dentistry ,030204 cardiovascular system & hematology ,medicine.disease ,Gastroenterology ,Bone resorption ,3. Good health ,Bone remodeling ,03 medical and health sciences ,0302 clinical medicine ,N-terminal telopeptide ,Clinical attachment loss ,Internal medicine ,Heart failure ,medicine ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
AIMS Heart failure (HF) is a multi-organ, pro-inflammatory syndrome that impairs bone metabolism. Pro-inflammatory cytokines and bone catabolism enhance periodontal disease, a local inflammatory, bacteria-induced disease that causes bone loss and periodontal soft tissue destruction. METHODS AND RESULTS Medical and dental examinations were performed on patients with HF (n = 39), following heart transplantation (post-HTx, n = 38) and controls (n = 32). Blood, saliva, and gingival crevicular fluid were analysed for bone metabolism and inflammation markers. HF average New York Heart Association classification was III. Average time since HTx was 1414 days. Pro-inflammatory tumour necrosis factor-alpha was higher in HF and HTx as compared with controls (P
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- 2017
12. Reconsideration of Inferior Vena Cava Parameters for Estimating Right Atrial Pressure in an East Asian Population ― Comparative Simultaneous Ultrasound-Catheterization Study ―
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Tomoko Nakao, Takeshi Okubo, Seitetsu L. Lee, Boqing Xu, Tomoko S. Kato, Takayuki Kawata, Yutaka Yatomi, Megumi Hirokawa, Masao Daimon, Shuo Ju Chiang, Naoko Sawada, Keitaro Mahara, Masafumi Watanabe, Issei Komuro, and Koichi Kimura
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Adult ,Male ,medicine.medical_specialty ,Population ,Vena Cava, Inferior ,030204 cardiovascular system & hematology ,Inferior vena cava ,Catheterization ,03 medical and health sciences ,Atrial Pressure ,0302 clinical medicine ,Asian People ,Internal medicine ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,education ,Aged ,Ultrasonography ,Body surface area ,education.field_of_study ,Asia, Eastern ,business.industry ,fungi ,Ultrasound ,Central venous pressure ,General Medicine ,Middle Aged ,Surgery ,Cross-Sectional Studies ,medicine.vein ,cardiovascular system ,Population data ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
BACKGROUND Ultrasound measurements of the inferior vena cava (IVC) diameter (IVCD), together with its respiratory variation, provide a noninvasive estimate of right atrial pressure (RAP). However, there is a paucity of studies that have compared this technique with simultaneous catheterization. We explored the best cut-off values of IVC parameters for elevated RAP in comparison with RAP measured by catheterization.Methods and Results:We prospectively enrolled 120 East Asian patients who were scheduled for catheterization. The IVCD and IVC collapsibility index (IVCCI) were measured according to the current guidelines. The optimal maximum IVCD (IVCDmax) and IVCCI cut-offs for detecting elevated RAP (RAP ≥10 mmHg) were 17 mm and 40%, respectively. When we combined both in proportion to the guidelines, the sensitivity and specificity for detecting elevated RAP were 75% and 94%, respectively. When the cut-off values from the current guidelines (>21 mm and
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- 2017
13. Use of Cardiac Imaging to Evaluate Cardiac Function and Pulmonary Hemodynamics in Patients with Heart Failure
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Toru Satoh, Tomoko S. Kato, and Masao Daimon
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Cardiac function curve ,Lung Diseases ,medicine.medical_specialty ,Cardiac Catheterization ,Cardiac computed tomography ,Hemodynamics ,030204 cardiovascular system & hematology ,Doppler echocardiography ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine.artery ,medicine ,Humans ,In patient ,030212 general & internal medicine ,Lung ,Cardiac imaging ,Heart Failure ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,medicine.disease ,Cardiac Imaging Techniques ,Heart failure ,Pulmonary artery ,cardiovascular system ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Noninvasive hemodynamic assessments in patients with heart failure (HF) are essential for appropriate diagnosis and establishment of the best treatment strategies. Recently, the impact of pulmonary circulation and right ventricular function on prognosis in HF patients has drawn increasing attention. In this article, we explore the usefulness of cardiac imaging for hemodynamic assessments, mainly focusing on echocardiographic evaluation. The reliability of Doppler echocardiography as a noninvasive alternative to Swan-Ganz catheterization has been well investigated with higher than 80% accuracy for estimating pulmonary artery pressure. Strain measurement and three-dimensional echocardiography are useful for evaluating right ventricular function together with pulmonary circulation. The accuracy of analyzing left and right ventricular functions by cardiac computed tomography and cardiac magnetic resonate imaging has also been established. These modalities can provide myocardial tissue information and allow calculation of the extracellular volume fraction as well. According to the rapid improvement of technologies, cardiac imaging has become an essential tool for hemodynamic evaluation in HF management.
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- 2019
14. The Significance of the Effect of Visceral Adiposity on Left Ventricular Diastolic Function in the General Population
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Koichi Kimura, Masafumi Watanabe, Koki Nakanishi, Naoko Sawada, Issei Komuro, Boqing Xu, Yutaka Yatomi, Makoto Kurano, Tomoko S. Kato, Megumi Hirokawa, Masao Daimon, Tomoko Nakao, Takayuki Kawata, and Yuko Yamanaka
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0301 basic medicine ,Male ,medicine.medical_specialty ,Population ,Diastole ,lcsh:Medicine ,Computed tomography ,Plasma adiponectin ,Intra-Abdominal Fat ,Article ,03 medical and health sciences ,Ventricular Dysfunction, Left ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Diastolic function ,lcsh:Science ,education ,Serum adiponectin ,education.field_of_study ,Multidisciplinary ,medicine.diagnostic_test ,Adiponectin ,business.industry ,lcsh:R ,Middle Aged ,medicine.disease ,Prognosis ,Obesity ,030104 developmental biology ,Cross-Sectional Studies ,Obesity, Abdominal ,Cardiology ,lcsh:Q ,Female ,business ,030217 neurology & neurosurgery ,hormones, hormone substitutes, and hormone antagonists - Abstract
We evaluated the association between visceral adiposity and left ventricular (LV) diastolic function in association with plasma adiponectin levels in 213 subjects without overt cardiac diseases. Abdominal visceral fat area was quantified by computed tomography. Excessive visceral fat was significantly associated with impaired diastolic parameters including E/A, E′ and E/E′. Although serum adiponectin levels decreased with increased visceral adiposity, there was no independent association between serum adiponectin levels and diastolic parameters, which suggest that the role of adiponectin in this association might be indirect.
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- 2019
15. Vascular inflammation and abnormal aortic histomorphometry in patients after pulsatile- and continuous-flow left ventricular assist device placement
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Peter J. Kennel, Isaac George, Katherine Xu, Hirokazu Akashi, P. Christian Schulze, Danielle L. Brunjes, Christina Wu, Hiroo Takayama, Ruiping Ji, Yoshifumi Naka, Michael Lee, Maryjane Farr, Matthew P. Weber, Donna M. Mancini, Tomoko S. Kato, and Elias Collado
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.medical_treatment ,Pulsatile flow ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,Internal medicine ,medicine ,Humans ,Ventricular Assist Device Placement ,030212 general & internal medicine ,Aorta ,Heart Failure ,Inflammation ,Heart transplantation ,Transplantation ,Decellularization ,business.industry ,medicine.disease ,Treatment Outcome ,Ventricular assist device ,Heart failure ,cardiovascular system ,Cardiology ,Surgery ,Heart-Assist Devices ,Cardiology and Cardiovascular Medicine ,business ,Destination therapy - Abstract
Background Left ventricular assist devices are increasingly being used in patients with advanced heart failure as both destination therapy and bridge to transplant. We aimed to identify histomorphometric, structural and inflammatory changes after pulsatile- and continuous-flow left ventricular assist device placement. Methods Clinical and echocardiographic data were collected from medical records. Aortic wall diameter, cellularity and inflammation were assessed by immunohistochemistry on aortic tissue collected at left ventricular assist device placement and at explantation during heart transplantation. Expression of adhesion molecules was quantified by Western blot. Results Decellularization of the aortic tunica media was observed in patients receiving continuous-flow support. Both device types showed an increased inflammatory response after left ventricular assist device placement with variable T-cell and macrophage accumulations and increased expression of vascular E-selectin, ICAM and VCAM in the aortic wall. Conclusions Left ventricular assist device implantation is associated with distinct vascular derangements with development of vascular inflammation. These changes are pronounced in patients on continuous-flow left ventricular assist and associated with aortic media decellularization. The present findings help to explain the progressive aortic root dilation and vascular dysfunction in patients after continuous-flow device placement.
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- 2016
16. Preoperative hepatic dysfunction could predict postoperative mortality and morbidity in patients undergoing cardiac surgery: Utilization of the MELD scoring system
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Tomoko S. Kato, Atsushi Amano, Taira Yamamoto, Kenji Kuwaki, Shizuyuki Dohi, and Mai Murata
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Male ,medicine.medical_specialty ,Heart Diseases ,030204 cardiovascular system & hematology ,Risk Assessment ,Severity of Illness Index ,End Stage Liver Disease ,03 medical and health sciences ,Liver disease ,0302 clinical medicine ,Japan ,medicine ,Humans ,In patient ,Postoperative Period ,Cardiac Surgical Procedures ,Aged ,Retrospective Studies ,Ejection fraction ,business.industry ,Prognosis ,medicine.disease ,Cardiac surgery ,Surgery ,Survival Rate ,body regions ,030228 respiratory system ,Preoperative Period ,Cohort ,Female ,Morbidity ,Liver dysfunction ,Cardiology and Cardiovascular Medicine ,Risk assessment ,Hepatic dysfunction ,business ,Follow-Up Studies - Abstract
According to recent advances in operative techniques, an increasing number of patients with liver dysfunction have been subjected to cardiac surgery. Model of End-Stage Liver Disease (MELD and MELD-XI) scores allow risk stratification of patients undergoing cardiac and non-cardiac surgeries.We retrospectively analyzed 1856 consecutive patients (69.3% male, mean 66.8 ± 12.2 years) undergoing cardiac surgery between 2008 and 2013 at our institution.The mean values of MELD/MELD-XI scores obtained from the total cohort were 9.7 ± 4.6/11.9 ± 4.8. Patients with high MELD/MELD-XI scores (12) were older, more anemic, and had lower left ventricular ejection fraction than those with low scores (all p0.0001). High scores were associated with longer hospitalization (36.8 ± 33.0 vs. 23.6 ± 21.5 days for MELD, 36.7 ± 34.0 vs. 23.5 ± 21.0 days for MELD-XI, both p0.0001) and higher in-hospital all-cause mortality (6.6% vs. 1.0% for MELD, 7.7% vs. 0.7% for MELD-XI). Atrial fibrillation occurred more frequently in the high MELD group, but this difference was not found for MELD-XI. MELD/MELD-XI could predict mortality with a sensitivity of 64.3%/60.0% and specificity of 79.1%/85.3%. Comparison of AUC values among MELD scores, individual MELD components, and Child-Turcotte-Pugh (CTP) classification showed that the predictive strength of MELD scores for mortality was stronger than individual parameters or CTP classification (AUC: 0.7702 for MELD, 0.7655 for MELD-XI, 0.5799 for CTP classification with pairwise p0.0001 and p=0.0002 vs. MELD and MELD-XI, respectively).Assessment of liver dysfunction using the MELD scores can be useful for predicting postoperative morbidity and mortality, which may allow additional risk stratification in patients undergoing cardiac surgery.
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- 2016
17. Supplementation of <scp>l</scp> -Alanyl- <scp>l</scp> -Glutamine and Fish Oil Improves Body Composition and Quality of Life in Patients With Chronic Heart Failure
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Danielle L. Brunjes, Ruiping Ji, Jennifer Hall, Peter J. Kennel, Aalap Chokshi, Christina Wu, Yue Deng, Hirokazu Akashi, P. Christian Schulze, Daniel E. Forman, Donna M. Mancini, David S. Seres, Hilary F. Armstrong, Matthew N. Bartels, Tomoko S. Kato, Tiffany Thomas, and Cynthia F. Zizola
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Male ,medicine.medical_specialty ,Glutamine ,Exercise intolerance ,Article ,Grip strength ,Fish Oils ,Double-Blind Method ,Internal medicine ,Hand strength ,Humans ,Medicine ,Muscle, Skeletal ,Heart Failure ,chemistry.chemical_classification ,Exercise Tolerance ,Hand Strength ,business.industry ,Skeletal muscle ,Middle Aged ,medicine.disease ,Fish oil ,Treatment Outcome ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Heart failure ,Chronic Disease ,Dietary Supplements ,Body Composition ,Quality of Life ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Polyunsaturated fatty acid - Abstract
Background— Skeletal muscle dysfunction and exercise intolerance are clinical hallmarks of patients with heart failure. These have been linked to a progressive catabolic state, skeletal muscle inflammation, and impaired oxidative metabolism. Previous studies suggest beneficial effects of ω-3 polyunsaturated fatty acids and glutamine on exercise performance and muscle protein balance. Methods and Results— In a randomized double-blind, placebo-controlled trial, 31 patients with heart failure were randomized to either l -alanyl- l -glutamine (8 g/d) and polyunsaturated fatty acid (6.5 g/d) or placebo (safflower oil and milk powder) for 3 months. Cardiopulmonary exercise testing, dual-energy x-ray absorptiometry, 6-minute walk test, hand grip strength, functional muscle testing, echocardiography, and quality of life and lateral quadriceps muscle biopsy were performed at baseline and at follow-up. Oxidative capacity and metabolic gene expression were analyzed on muscle biopsies. No differences in muscle function, echocardiography, 6-minute walk test, or hand grip strength and a nonsignificant increase in peak V O 2 in the treatment group were found. Lean body mass increased and quality of life improved in the active treatment group. Molecular analysis revealed no differences in muscle fiber composition, fiber cross-sectional area, gene expression of metabolic marker genes (PGC1α, CPT1, PDK4, and GLUT4), and skeletal muscle oxidative capacity. Conclusions— The combined supplementation of l -alanyl- l -glutamine and polyunsaturated fatty acid did not improve exercise performance or muscle function but increased lean body mass and quality of life in patients with chronic stable heart failure. These findings suggest potentially beneficial effects of high-dose nutritional polyunsaturated fatty acids and amino acid supplementations in patients with chronic stable heart failure. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT01534663.
- Published
- 2015
18. Left and Right Ventricular Functional Dynamics Determined by Echocardiograms Before and After Lung Transplantation
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Atsushi Amano, Matthew Bacchetta, Marco R. Di Tullio, Donna M. Mancini, Maryjane Farr, Shunichi Homma, Matthew N. Bartels, Matthew Lippel, Hilary F. Armstrong, P. Christian Schulze, and Tomoko S. Kato
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Adult ,Lung Diseases ,Male ,Cardiac function curve ,medicine.medical_specialty ,medicine.medical_treatment ,Functional dynamics ,Speckle tracking echocardiography ,Article ,Ventricular Function, Left ,Internal medicine ,medicine ,Humans ,Lung transplantation ,Contraindication ,Retrospective Studies ,Ultrasonography ,Exercise Tolerance ,Ejection fraction ,business.industry ,Cardiopulmonary exercise ,Stroke Volume ,Middle Aged ,Treatment Outcome ,Fractional area change ,Exercise Test ,Ventricular Function, Right ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Lung Transplantation - Abstract
Impaired cardiac function is considered a contraindication for lung transplantation (LT). Because right ventricular (RV) function is expected to improve after LT, poor left ventricular (LV) function is often the determinant for LT eligibility. However, the changes in cardiac function before and after LT have not yet been elucidated. Therefore, we reviewed echocardiograms obtained from 67 recipients before and after LT. In a subset of 49 patients, both RV and LV longitudinal strains based on 2-dimensional speckle tracking echocardiography were analyzed. The cardiopulmonary exercise tests were also reviewed. All patients showed significant improvements in their exercise capacity after LT. RV echo parameters improved in all patients after LT (RV fractional area change: 36.7 ± 5.6% to 41.5 ± 2.7%, RV strain: -15.5 ± 2.9% to -18.0 ± 2.1%, RV E/E': 8.4 ± 1.8 to 7.7 ± 1.8; all p0.05). Overall, the left ventricular ejection fraction (LVEF) did not change (58.7 ± 6.0% to 57.5 ± 9.7%, p = 0.385); however, 20 patients (30%) showed10% decrease in LVEF after LT (61.5 ± 6.1% to 47.3 ± 4.2%, p0.001) and an increase in LV E/E' (11.8 ± 1.8 to 12.9 ± 2.2, p = 0.049). Multivariate logistic regression analysis revealed that pre-LT LV E/E' was associated with decrease in LVEF after LT (odds ratio 1.381, 95% confidence interval 1.010 to 1.947, p = 0.043). Furthermore, patients with strain data showed that lower pre-LT LV strain was independently associated with LVEF decrease after LT (odds ratio 1.293, 95% confidence interval 1.088 to 1.614, p = 0.002). Although RV function improves after LT, LV systolic and diastolic functions deteriorate in a sizable proportion of patients. Impaired LV diastolic function before transplant appears to increase the risk of LVEF deterioration after LT.
- Published
- 2015
19. Preoperative Factors Associated With Postoperative Requirements of Renal Replacement Therapy Following Cardiac Surgery
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Hirotaka Inaba, Atsushi Amano, Tomoko S. Kato, Taira Yamamoto, Atsumi Oishi, Kenji Kuwaki, and Yuichiro Sato
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,urologic and male genital diseases ,Postoperative Complications ,Japan ,medicine ,Humans ,Intubation ,Renal replacement therapy ,Cardiac Surgical Procedures ,Single institution ,Adverse effect ,Aged ,Retrospective Studies ,Postoperative Care ,business.industry ,Incidence ,Acute Kidney Injury ,Prognosis ,female genital diseases and pregnancy complications ,Surgery ,Perioperative blood loss ,Cardiac surgery ,Renal Replacement Therapy ,ROC Curve ,Anesthesia ,Preoperative Period ,Female ,Hemodialysis ,Cardiology and Cardiovascular Medicine ,business - Abstract
Renal dysfunction is a major adverse event after cardiovascular surgery. Therefore, the preoperative prediction of which patients will require renal replacement therapy (RRT) after cardiac surgery is an important issue. In the present study, 1,822 consecutive patients who underwent cardiovascular surgery from 2008 and 2013 at a single institution were reviewed. Patients who were already receiving long-term hemodialysis before surgery (n = 134) were excluded. The remaining 1,688 patients were separated into 2 groups: those requiring postoperative RRT and those without RRT requirement. A total of 128 patients (7.6%) required RRT. Patients requiring RRT had greater perioperative blood loss, longer intubation time, and longer hospital stays (p0.0001 for all). Multivariate analysis revealed that cardiopulmonary bypass use, preoperative body surface area, the left ventricular ejection fraction, serum albumin, and creatinine were independent risk factors for postoperative RRT (odds ratios 2.435, 0.204, 0.976, 0.556, and 5.394, 95% confidence intervals 1.471 to 4.140, 0.054 to 0.841, 0.962 to 1.025, 0.363 to 0.860, and 3.671 to 8.223, respectively, p0.05 for all). A subgroup of patients with relatively preserved renal function before surgery (creatinine1.12 mg/dl, a cut-off value for RRT requirement obtained from receiver-operating characteristic curve analysis [area under the curve 0.74748, sensitivity 60.2%, specificity 85.0%]) showed that preoperative serum albumin concentration was most significantly associated with postoperative RRT requirement (odds ratio 0.048, 95% confidence interval 0.023 to 0.095, p0.0001). In conclusion, cardiopulmonary bypass use, preoperative renal impairment as reflected by elevated creatinine level, small body size, a low left ventricular ejection fraction, and hypoalbuminemia were associated with a requirement for postoperative RRT. In patients with preserved renal function, hypoalbuminemia was most significantly related to requirement for RRT.
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- 2015
20. Combination of liver biopsy with MELD-XI scores for post-transplant outcome prediction in patients with advanced heart failure and suspected liver dysfunction
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Jean C. Emond, Lorna Dove, Tomoko S. Kato, Hiroo Takayama, Yoshifumi Naka, Zhezhen Jin, James M. Mitchell, Maryjane Farr, Ulrich P. Jorde, Matthew Lippel, Paul Ippolito, Jay H. Lefkowitch, P. Christian Schulze, and Donna Mancini
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Time Factors ,Biopsy ,medicine.medical_treatment ,Risk Assessment ,Severity of Illness Index ,Article ,End Stage Liver Disease ,Liver disease ,Risk Factors ,Internal medicine ,medicine ,Humans ,Retrospective Studies ,Heart Failure ,Heart transplantation ,Transplantation ,Framingham Risk Score ,medicine.diagnostic_test ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,Liver ,Congestive hepatopathy ,Heart failure ,Liver biopsy ,Cardiology ,Heart Transplantation ,Female ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Functional and structural liver abnormalities may be found in patients with advanced heart failure (HF). The Model of End-Stage Liver Disease Excluding INR (MELD-XI) score allows functional risk stratification of HF patients on and off anti-coagulation awaiting heart transplantation (HTx), but these scores may improve or worsen depending on bridging therapies and during time on the waiting list. Liver biopsy is sometimes performed to assess for severity of fibrosis. Uncertainty remains whether biopsy in addition to MELD-XI improves prediction of adverse outcomes in patients evaluated for HTx.Sixty-eight patients suspected of advanced liver disease underwent liver biopsy as part of their HTx evaluation. A liver risk score (fibrosis-on-biopsy + 1) × MELD-XI was generated for each patient.Fifty-two patients were listed, of whom 14 had mechanical circulatory support (MCS). Thirty-six patients underwent transplantation and 27 patients survived ≥1 year post-HTx (74%, as compared with 88% average 1-year survival in HTx patients without suspected liver disease; p0.01). Survivors had a lower liver risk score at evaluation for HTx (31.0 ± 20.4 vs 65.2 ± 28.6, p0.01). A cut-point of 45 for liver risk score was identified by receiver-operating-characteristic (ROC) analysis. In the analysis using Cox proportional hazards models, a liver risk score ≥45 at evaluation for HTx was associated with greater risk of death at 1 year post-HTx compared with a score of45 in both univariable (HR 3.94, 95% CI 1.77-8.79, p0.001) and multivariable (HR 4.35, 95% CI 1.77-8.79, p0.001) analyses. Patients who died1 year post-HTx had an increased frequency of acute graft dysfunction (44.4% vs 3.7%, p = 0.009), longer ventilation times (55.6% vs 11.1%, p = 0.013) and severe bleeding events (44.4% vs 11.1%, p = 0.049). The liver risk score at evaluation for HTx also predicted 1-year mortality after HTx listing (p0.001).Patients with HF and advanced liver dysfunction are high-risk HTx candidates. Liver biopsy in addition to MELD-XI improves risk stratification of patients with advanced HF and suspected irreversible liver dysfunction.
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- 2015
21. Similar Survival in Patients Following Heart Transplantation Receiving Induction Therapy Using Daclizumab vs. Basiliximab
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Tomoko S. Kato, Donna M. Mancini, M. Ji, Hiroo Takayama, P. Christian Schulze, Yoshifumi Naka, Halit Yerebakan, Spencer T. Martin, Faisal H. Cheema, Maryjane Farr, Alexandra Ross, Jaclyn T. McKeen, and Susan Restaino
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Adult ,Male ,Oncology ,medicine.medical_specialty ,Daclizumab ,Transplantation Conditioning ,Basiliximab ,Recombinant Fusion Proteins ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,030230 surgery ,Antibodies, Monoclonal, Humanized ,Article ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,Internal medicine ,Induction therapy ,medicine ,Humans ,Survival rate ,Aged ,Retrospective Studies ,Heart transplantation ,business.industry ,Antibodies, Monoclonal ,Retrospective cohort study ,General Medicine ,Middle Aged ,3. Good health ,Survival Rate ,Immunoglobulin G ,Monoclonal ,Heart Transplantation ,Female ,Cardiology and Cardiovascular Medicine ,business ,Immunosuppressive Agents ,medicine.drug - Abstract
Induction therapy with interleukin-2 receptor antagonists has been established as an effective immunosuppressive strategy in the management of heart transplant (HTx) recipients. We compared outcomes following HTx in patients receiving basiliximab, daclizumab, or no induction therapy.We investigated post-transplant prognosis of patients receiving basiliximab (n=67), daclizumab (n=98) or no induction therapy (n=70). Patients treated with daclizumab (50.3 ± 14.7 years) were younger than those receiving basiliximab (55.8 ± 11.2 years) or no induction therapy (54.9 ± 14.1 years; both P0.05). Patients receiving either induction therapy showed better survival 1 year after HTx (95%) than those without induction therapy (82%; P0.001). Survival was similar between patients receiving basiliximab and daclizumab. The incidence of acute cellular or antibody-mediated rejections did not differ among the groups. The main reason that patients did not receive induction therapy was ongoing infection (65.7%), which was more common in patients on ventricular assist device (VAD) support than those without VAD (76.1% vs. 45.8%; P=0.004). The VAD-related infection rate in the entire study cohort was 29.7% (35/118 VAD recipients).Survival following HTx was worse in patients not receiving induction therapy. No differences were noted in survival or the incidence of rejection between the daclizumab- and basiliximab-treated groups. Induction therapy was less used in patients with infection, which was related to prior VAD support.
- Published
- 2015
22. Ventricular assist device implantation improves skeletal muscle function, oxidative capacity, and growth hormone/insulin-like growth factor-1 axis signaling in patients with advanced heart failure
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Peter J. Kennel, Aalap Chokshi, Tomoko S. Kato, Isaac George, Katherine Xu, Takeyoshi Ota, Ruiping Ji, Daniel E. Forman, Donna M. Mancini, Hiroo Takayama, Christina Wu, Cynthia F. Zizola, Yoshifumi Naka, Tuba Khawaja, and P. Christian Schulze
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medicine.medical_specialty ,CD36 ,medicine.medical_treatment ,Oxidative phosphorylation ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Grip strength ,Insulin-like growth factor ,0302 clinical medicine ,Physiology (medical) ,Internal medicine ,medicine ,Orthopedics and Sports Medicine ,030304 developmental biology ,0303 health sciences ,biology ,business.industry ,Growth factor ,Skeletal muscle ,medicine.disease ,Molecular medicine ,Endocrinology ,medicine.anatomical_structure ,Heart failure ,biology.protein ,Erratum ,business - Abstract
Skeletal muscle dysfunction in patients with heart failure (HF) has been linked to impaired growth hormone (GH)/insulin-like growth factor (IGF)-1 signaling. We hypothesized that ventricular assist device (VAD) implantation reverses GH/IGF-1 axis dysfunction and improves muscle metabolism in HF.Blood and rectus abdominis muscle samples were collected during VAD implantation and explantation from patients with HF and controls. Clinical data were obtained from medical records, biomarkers measured by enzyme-linked immunosorbent assay (ELISA), and gene expression analyzed by reverse transcription and real-time polymerase chain reaction (RT-PCR). Grip strength was assessed by dynamometry. Oxidative capacity was measured using oleate oxidation rates. Muscle fiber type and size were assessed by histology.Elevated GH (0.27 ± 0.27 versus 3.6 ± 7.7 ng/ml in HF; p = 0.0002) and lower IGF-1 and insulin-like growth factor binding protein (IGFBP)-3 were found in HF (IGF-1, 144 ± 41 versus 74 ± 45 ng/ml in HF, p 0.05; and IGFBP-3, 3,880 ± 934 versus 1,935 ± 862 ng/ml in HF, p = 0.05). The GH/IGF-1 ratio, a marker of GH resistance, was elevated in HF (0.002 ± 0.002 versus 0.048 ± 0.1 pre-VAD; p 0.0039). After VAD support, skeletal muscle expression of IGF-1 and IGFBP-3 increased (10-fold and 5-fold, respectively; p 0.05) accompanied by enhanced oxidative gene expression (CD36, CPT1, and PGC1α) and increased oxidation rates (+1.37-fold; p 0.05). Further, VAD implantation increased the oxidative muscle fiber proportion (38 versus 54 %, p = 0.031), fiber cross-sectional area (CSA) (1,005 ± 668 versus 1,240 ± 670 μm(2), p 0.001), and Akt phosphorylation state in skeletal muscle. Finally, hand grip strength increased 26.5 ± 27.5 % at 180 days on-VAD (p 0.05 versus baseline).Our data demonstrate that VAD implantation corrects GH/IGF-1 signaling, improves muscle structure and function, and enhances oxidative muscle metabolism in patients with advanced HF.
- Published
- 2014
23. Reduced Handgrip Strength as a Marker of Frailty Predicts Clinical Outcomes in Patients With Heart Failure Undergoing Ventricular Assist Device Placement
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Tien T. Dam, Tomoko S. Kato, Christina Wu, Danielle L. Templeton, Raymond C. Givens, Mathew S. Maurer, Donna M. Mancini, Meaghan Jones, P. Christian Schulze, Christine J. Chung, Yoshifumi Naka, and Hiroo Takayama
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Exercise intolerance ,Cohort Studies ,Postoperative Complications ,Predictive Value of Tests ,Hand strength ,Internal medicine ,Humans ,Medicine ,Ventricular Assist Device Placement ,Survival rate ,Heart Failure ,Hand Strength ,business.industry ,Middle Aged ,medicine.disease ,Survival Rate ,Treatment Outcome ,Predictive value of tests ,Ventricular assist device ,Heart failure ,Cardiology ,Female ,Heart-Assist Devices ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Cohort study - Abstract
Heart failure (HF) is associated with the derangement of muscle structure and metabolism, contributing to exercise intolerance, frailty, and mortality. Reduced handgrip strength is associated with increased patient frailty and higher morbidity and mortality. We evaluated handgrip strength as a marker of muscle function and frailty for prediction of clinical outcomes after ventricular assist device (VAD) implantation in patients with advanced HF.Handgrip strength was measured in 72 patients with advanced HF before VAD implantation (2.3 ± 4.9 days pre-VAD). We analyzed dynamics in handgrip strength, laboratory values, postoperative complications, and mortality. Handgrip strength correlated with serum albumin levels (r = 0.334, P = .004). Compared with baseline, handgrip strength increased post-VAD implantation by 18.2 ± 5.6% at 3 months (n = 29) and 45.5 ± 23.9% at 6 months (n = 27). Patients with a handgrip strength25% of body weight had an increased risk of mortality, increased postoperative complications, and lower survival after VAD implantation.Patients with advanced HF show impaired handgrip strength indicating a global myopathy. Handgrip strength25% of body weight is associated with higher postoperative complication rates and increased mortality after VAD implantation. Thus, the addition of measures of skeletal muscle function underlying the frailty phenotype to traditional risk markers might have incremental prognostic value in patients undergoing evaluation for VAD placement.
- Published
- 2014
24. Transthyretin Stabilizer Is Associated With Expanding Apical Sparing Area and Improving Global Cardiac Function in a Patient With Wild-Type Cardiac Amyloidosis
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Tomoko S. Kato, Naoko Ikeda, Mathew S. Maurer, Kaoru Tanno, and Yukio Ando
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Male ,Cardiac function curve ,medicine.medical_specialty ,Treatment outcome ,Internal medicine ,medicine ,Humans ,Aged ,Amyloid Neuropathies, Familial ,Benzoxazoles ,biology ,business.industry ,Wild type ,Heart ,General Medicine ,Cardiovascular physiology ,Transthyretin ,Amyloid Neuropathy ,Treatment Outcome ,Cardiac amyloidosis ,Cardiology ,biology.protein ,Cardiomyopathies ,Cardiology and Cardiovascular Medicine ,business ,Magnetic Resonance Angiography - Published
- 2019
25. Relation of Preoperative Serum Albumin Levels to Survival in Patients Undergoing Left Ventricular Assist Device Implantation
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Donna M. Mancini, Yoshifumi Naka, Jonathan Yang, Tomoko S. Kato, P. Christian Schulze, Hiroo Takayama, Shuichi Kitada, Christina Wu, and Maryjane Farr
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medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,New York ,Serum albumin ,Article ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Humans ,In patient ,Postoperative Period ,Hypoalbuminemia ,Survival rate ,Serum Albumin ,Retrospective Studies ,Heart Failure ,biology ,business.industry ,Retrospective cohort study ,Prognosis ,equipment and supplies ,medicine.disease ,Surgery ,Survival Rate ,Treatment Outcome ,Postoperative mortality ,Ventricular assist device ,Heart failure ,Preoperative Period ,biology.protein ,Cardiology ,Heart-Assist Devices ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Hypoalbuminemia has been recognized as a prognostic indicator in patients with heart failure. We aimed to investigate the association of hypoalbuminemia with postoperative mortality in patients undergoing left ventricular assist device (LVAD) implantation. We studied 272 consecutive patients undergoing LVAD implantation from 2000 to 2010 at our institution. Preoperative clinical characteristics and laboratory variables associated with mortality were analyzed. Postoperative survival of patients with preoperative hypoalbuminemia (
- Published
- 2013
26. Pre-operative echocardiographic features associated with persistent mitral regurgitation after left ventricular assist device implantation
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Yoshifumi Naka, Nir Uriel, Shunichi Homma, Donna M. Mancini, Hiroo Takayama, P. Christian Schulze, Suzanne D. Conwell, Tomoko S. Kato, Ulrich P. Jorde, Shuichi Kitada, Sunu S. Thomas, Maryjane Farr, Cesare Russo, and Marco R. Di Tullio
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Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.medical_treatment ,Severity of Illness Index ,Preoperative care ,Article ,Ventricular Dysfunction, Left ,Internal medicine ,Mitral valve ,Preoperative Care ,medicine ,Humans ,Aged ,Retrospective Studies ,Transplantation ,Mitral valve repair ,Mitral regurgitation ,business.industry ,Incidence ,Hazard ratio ,Mitral Valve Insufficiency ,Middle Aged ,equipment and supplies ,medicine.disease ,Surgery ,Survival Rate ,Treatment Outcome ,medicine.anatomical_structure ,Echocardiography ,Ventricle ,Ventricular assist device ,Heart failure ,Multivariate Analysis ,Cardiology ,Mitral Valve ,Female ,Heart-Assist Devices ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Previous studies have shown remarkable decrease in size of the left ventricle after left ventricular assist device (LVAD) implantation due to mechanical unloading. However, a certain number of patients continue to have significant mitral regurgitation (MR) under LVAD support. We investigated pre-operative echocardiographic features associated with persistent MR after LVAD implantation. Methods We retrospectively reviewed 82 consecutive patients undergoing continuous-flow LVAD implantation between 2007 and 2010. We obtained echocardiograms performed within 2 weeks before and 1 week after surgery. We investigated the pre-operative echocardiographic findings associated with significant MR post-LVAD and compared 1-year mortality after LVAD surgery between patients with and without significant MR post-LVAD. Results MR was significant in 43 patients (52.4%) before LVAD surgery. Among those, 5 underwent concomitant mitral valve repair (MVr) at the time of LVAD implantation. Of the remaining 38 patients, 25 (65.8%) showed improvement of MR, whereas 13 patients (34.2%) continued to have significant MR post-LVAD. Multivariate analysis revealed that posterior displacement of the coaptation point of mitral leaflets was significantly associated with significant MR post-LVAD (hazard ratio, 1.335; 95% confidence interval, 1.035–1.721; p = 0.026) even after adjusting for the amount of pre-operative MR flow. Post-LVAD 1-year survival of patients with and without significant MR post-LVAD was not significantly different (92.3% vs 89.1%, p = 0.826). Conclusions Pre-LVAD posterior displacement of mitral leaflets may be indicative of post-operative significant MR, which would help identify echocardiographic features of functional MR refractory to simple volume reduction of the ventricle.
- Published
- 2013
27. Hepatic Dysfunction in Ambulatory Patients With Heart Failure
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Margaret Kim, Ellias Collado, Tomoko S. Kato, P. Christian Schulze, Christina Wu, Maryjane Farr, Raymond C. Givens, and Donna M. Mancini
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Heart transplantation ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Hazard ratio ,Retrospective cohort study ,medicine.disease ,Surgery ,body regions ,Liver disease ,Internal medicine ,Heart failure ,Ventricular assist device ,Severity of illness ,Ambulatory ,medicine ,Cardiology ,business ,Cardiology and Cardiovascular Medicine - Abstract
Objectives This study evaluated the Model for End-Stage Liver Disease (MELD) score and its modified versions, which are established measures of liver dysfunction, as a tool to assess heart transplantation (HTx) urgency in ambulatory patients with heart failure. Background Liver abnormalities have a prognostic impact on the outcome of patients with advanced heart failure. Methods We retrospectively evaluated 343 patients undergoing HTx evaluation between 2005 and 2009. The prognostic effectiveness of MELD and 2 modifications (MELDNa [includes serum sodium levels] and MELD-XI [does not include international normalized ratio]) for endpoint events, defined as death/HTx/ventricular assist device requirement, was evaluated in our cohort and in subgroups of patients on and off oral anticoagulation. Results The MELD and MELDNa scores were excellent predictors for 1-year endpoint events (areas under the curve: 0.71 and 0.73, respectively). High scores (>12) were strongly associated with poor survival at 1 year (MELD 69.3% vs. 90.4% [p < 0.0001]; MELDNa 70.4% vs. 96.9% [p < 0.0001]). Increased scores were associated with increased risk for HTx (hazard ratio: 1.10 [95% confidence interval: 1.06 to 1.14]; p < 0.0001 for both scores), which was independent of other known risk factors (MELD p ¼ 0.0055; MELDNa p ¼ 0.0083). Anticoagulant use was associated with poor survival at 1 year (73.7% vs. 86.4%; p ¼ 0.0118), and the statistical significance of MELD/MELDNa was higher in patients not receiving oral anticoagulation therapy. MELD-XI was a fair but limited predictor of the endpoint events in patients receiving oral anticoagulation therapy. Conclusions Assessment of liver dysfunction according to the MELD scoring system provides additional risk information in ambulatory patients with heart failure. (J Am Coll Cardiol 2013;61:2253–61) a 2013 by the American College of Cardiology Foundation
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- 2013
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28. Right ventricular stroke work index as a negative predictor of mortality and initial hospital stay after lung transplantation
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Wilawan Thirapatarapong, Tomoko S. Kato, Matthew N. Bartels, Matthew Bacchetta, P. Christian Schulze, and Hilary F. Armstrong
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Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Cystic Fibrosis ,medicine.medical_treatment ,Diastole ,Article ,Cohort Studies ,Pulmonary Disease, Chronic Obstructive ,Predictive Value of Tests ,Risk Factors ,Intensive care ,medicine.artery ,Internal medicine ,medicine ,Humans ,Lung transplantation ,Hospital Mortality ,Survival rate ,Aged ,Retrospective Studies ,Transplantation ,Ejection fraction ,business.industry ,Stroke Volume ,Stroke volume ,Length of Stay ,Middle Aged ,Survival Rate ,Pulmonary artery ,Ventricular Function, Right ,Cardiology ,Female ,Surgery ,Lung Diseases, Interstitial ,Cardiology and Cardiovascular Medicine ,business ,Respiratory minute volume ,Lung Transplantation - Abstract
Background Studies have shown that patients with poor pre-lung transplant (LTx) right ventricular (RV) function have prolonged post-operative ventilation time and intensive care stay as well as a higher risk of in-hospital death. RV stroke work index (RVSWI) calculates RV workload and contractility. We hypothesized that patients with higher RV workload capacity, indicated by higher RVSWI, would have better outcomes after LTx. Methods A retrospective record review was performed on all LTx patients between 2005 and 2011 who had right heart catheterizations (RHC) 1-year before LTx. In addition, results for echocardiograms and cardiopulmonary exercise testing within 1-year of RHCs were gathered. Results Mean RVSWI was 9.36 ± 3.59 for 115 patients. There was a significant relation between mean pulmonary artery pressure (mPAP), RVSWI, RV end-diastolic diameter (RVEDd), left atrial dimension (LAD), peak and resting pressure of end-tidal carbon dioxide, minute ventilation /volume of carbon dioxide production , and 1-year mortality after LTx. Contrary to our hypothesis, those who survived had lower RVSWI than those who died within 1 year (8.99 ± 3.38 vs 11.6 ± 4.1, p = 0.026). Hospital length of stay significantly correlated with mPAP, RVSWI, left ventricular ejection fraction, percentage of fractional shortening, RVEDd, RV fractional area change, LAD, and RV wall thickness in diastole. Intensive care length of stay also significantly correlated with these variables and with body mass index. RVSWI was significantly different between groups of different RV function, indicating that increased RVSWI is associated with impairment of RV structure and function in patients undergoing LTx evaluation. Conclusions This study demonstrates an association between 1-year mortality, initial hospital and intensive care length of stay, and pre-LTx RVSWI. Increased mPAP is a known risk for outcomes in LTx patients. Our findings support this fact and also show increased mortality with elevation of RVSWI, demonstrating the value of RV function in the assessment of risk for pre-LTx patients.
- Published
- 2013
29. Preoperative Assessment of High-Risk Candidates to Predict Survival After Heart Transplantation
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Mathew S. Maurer, P. Christian Schulze, Jennifer Haythe, Sun Hi Lee, Ron Drusin, Yoshifumi Naka, Mario C. Deng, Kenneth Schaeffle, Maryjane Farr, Paolo C. Colombo, Farhana Latif, Jonathan Yang, Donna M. Mancini, Hiroo Takayama, Rachel Bijou, Ulrich P. Jorde, Jeffrey Jiang, Nir Uriel, Susan Restaino, Tomoko S. Kato, Evelyn M. Horn, and Faisal H. Cheema
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Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Kaplan-Meier Estimate ,Article ,Prognostic score ,Postoperative Complications ,Sex Factors ,Risk Factors ,Internal medicine ,medicine ,Humans ,Proportional Hazards Models ,Heart Failure ,Heart transplantation ,Framingham Risk Score ,Clinical events ,Proportional hazards model ,business.industry ,Medical record ,Amyloidosis ,Middle Aged ,Prognosis ,medicine.disease ,Surgery ,Transplantation ,Heart failure ,Preoperative Period ,Heart Transplantation ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background— Alternate waiting list strategies expand listing criteria for patients awaiting heart transplantation (HTx). We retrospectively analyzed clinical events and outcome of patients listed as high-risk recipients for HTx. Methods and Results— We analyzed 822 adult patients who underwent HTx of whom 111 patients met high-risk criteria. Clinical data were collected from medical records and outcome factors calculated for 61 characteristics. Significant factors were summarized in a prognostic score. Age >65 years (67%) and amyloidosis (19%) were the most common reasons for alternate listing. High-risk recipients were older (63.2±10.2 versus 51.4±11.8 years; P P =0.0005). Prior cerebral vascular accident, albumin 2 prior sternotomies were associated with poor survival after HTx. A prognostic risk score (CARRS [CVA, albumin, re-HTx, renal dysfunction, and sternotomies]) derived from these factors stratified survival post-HTx in high-risk (3+ points) versus low-risk (0–2 points) patients (87.9% versus 52.9% at 1-year; 65.9% versus 28.4% at 5-year post-HTx; P P =0.46). Conclusions— High-risk patients had reduced survival compared with regular patients post-HTx. Among patients previously accepted for alternate donor listing, application of the CARRS score identifies patients with unacceptably high mortality after HTx and those with a survival similar to regularly listed patients.
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- 2013
30. Risk stratification of ambulatory patients with advanced heart failure undergoing evaluation for heart transplantation
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Donna M. Mancini, Gerin R. Stevens, Maryjane Farr, P. Christian Schulze, Shunichi Homma, Matthew Lippel, Jeffrey Jiang, Tomoko S. Kato, Alison Levin, and Natalie Gukasyan
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.medical_treatment ,Risk Assessment ,Severity of Illness Index ,Article ,Ambulatory care ,Internal medicine ,Severity of illness ,Ambulatory Care ,Humans ,Medicine ,Retrospective Studies ,Heart Failure ,Heart transplantation ,Transplantation ,Ejection fraction ,business.industry ,Patient Selection ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Heart failure ,Ambulatory ,Cohort ,Disease Progression ,Cardiology ,Heart Transplantation ,Female ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Abstract
Risk stratification of ambulatory heart failure (HF) patients has relied on peak VO(2)14 ml/kg/min. We investigated whether additional clinical variables might further specify risk of death, ventricular assist device (VAD) implantation (INTERMACS4) or heart transplantation (HTx, Status 1A or 1B) within 1 year after HTx evaluation. We hypothesized that right ventricular stroke work index (RVSWI), pulmonary capillary wedge pressure (PCWP) and the model for end-stage liver disease-albumin score (MELD-A) would be additive prognostic predictors.We retrospectively collected data on 151 ambulatory patients undergoing HTx evaluation. Primary outcomes were defined as HTx, LVAD or death within 1 year after evaluation.Average age in our cohort was 55 ± 11.1 years, 79.1% were male and 39% had an ischemic etiology (LVEF 21 ± 10.5% and peak VO(2) 12.6 ± 3.5 ml/kg/min). Fifty outcomes (33.1%) were observed (27 HTxs, 15 VADs and 8 deaths). Univariate logistic regression showed a significant association of RVSWI (OR 0.47, p = 0.036), PCWP (OR 2.65, p = 0.007) and MELD-A (OR 2.73, p = 0.006) with 1-year events. Stepwise regression showed an independent correlation of RVSWI5gm-m(2)/beat (OR 6.70, p0.01), PCWP20 mm Hg (OR 5.48, p0.01), MELD-A14 (OR 3.72, p0.01) and peak VO(2)14 ml/kg/min (OR 3.36, p = 0.024) with 1-year events. A scoring system was developed: MELD-A14 and peak VO(2)14-1 point each; and PCWP20 and RVSWI5-2 points each. A cut-off at≥4 demonstrated a 54% sensitivity and 88% specificity for 1-year events.Ambulatory HF patients have significant 1-year event rates. Risk stratification based on exercise performance, left-sided congestion, right ventricular dysfunction and liver congestion allows prediction of 1-year prognosis. Our findings support early and timely referral for VAD and/or transplant.
- Published
- 2013
31. Value of Peak Exercise Oxygen Consumption Combined With B-type Natriuretic Peptide Levels for Optimal Timing of Cardiac Transplantation
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Tuba Khawaja, Elias Collado, Tomoko S. Kato, Yumeko Kawano, P. Christian Schulze, Margaret Kim, Donna M. Mancini, and Maryjane Farr
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Heart transplantation ,medicine.medical_specialty ,business.industry ,medicine.drug_class ,medicine.medical_treatment ,Hazard ratio ,Retrospective cohort study ,medicine.disease ,Surgery ,Transplantation ,Ventricular assist device ,Internal medicine ,Heart failure ,medicine ,Cardiology ,Natriuretic peptide ,Cardiology and Cardiovascular Medicine ,business ,Peak exercise - Abstract
Background— Peak exercise oxygen consumption (VO 2 ) is widely used to select candidates for heart transplantation (HTx). However, the prognosis of patients with advanced heart failure and peak VO 2 of 10 to 14 mL/min per kg in the era of modern medical therapy for heart failure is not fully elucidated. B-type natriuretic peptide (BNP) is a useful prognostic marker in patients with heart failure. Methods and Results— A total of 424 patients undergoing HTx evaluation were classified according to peak VO 2 during cardiopulmonary exercise testing (>14, 10–14, and 2 were independently associated with death, HTx, or VAD requirements (hazard ratio, 3.5 and 0.6; 95% CI, 1.24–9.23 and 0.03–0.71; P =0.02 and 2 10 to 14 mL/min per kg was identical to post-HTx survival. When patients with peak VO 2 10 to 14 mL/min per kg were dichotomized by a cutoff value of BNP of 506 pg/mL, those with BNPP =0.61), whereas those with BNP≥506 showed worse VAD-free or HTx-free survival (1 year: 79.7%; P 2 P =0.01). Conclusions— Patients with peak VO 2 10 to 14 mL/min per kg and low BNP levels have a VAD-free or HTx-free survival similar to post-HTx survival in heart recipients, whereas high BNP levels indicate worse outcome in this group of patients.
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- 2013
32. Outcome of patients with cardiac sarcoidosis undergoing cardiac transplantation—Single-center retrospective analysis
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P. Christian Schulze, Donna M. Mancini, Hirokazu Akashi, Hiroo Takayama, Tomoko S. Kato, Yoshifumi Naka, and Maryjane Farr
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Adult ,Male ,medicine.medical_specialty ,Sarcoidosis ,medicine.medical_treatment ,Population ,Heart failure ,Cardiac sarcoidosis ,Kaplan-Meier Estimate ,Single Center ,Internal medicine ,medicine ,Retrospective analysis ,Humans ,education ,Retrospective Studies ,Heart transplantation ,Transplantation ,education.field_of_study ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,Survival Rate ,Treatment Outcome ,Cardiology ,Heart Transplantation ,Female ,business ,Cardiomyopathies ,Cardiology and Cardiovascular Medicine - Abstract
Background Controversy exists whether heart transplantation (HTx) is an appropriate treatment option for patients with cardiac sarcoidosis due to its potential recurrence and multi-organ involvement. Recent data from the United Network for Organ Sharing dataset suggest that the clinical outcome of cardiac sarcoidosis patients is equivalent or even better than that of the general HTx population. Methods We retrospectively reviewed the clinical course of 14 patients with cardiac sarcoidosis among a total of 825 patients who underwent HTx at Columbia University Medical Center between 1997 and 2010. Post-transplant survival of patients with sarcoidosis was compared with that of non-sarcoidosis patients. Results More than half of cardiac sarcoidosis patients were initially diagnosed after HTx by tissue analysis of the explanted heart. While only 2/14 cases showed recurrence of cardiac sarcoidosis, the clinical outcome of sarcoid patients showed a trend toward higher mortality than that of non-sarcoidosis patients following HTx (1- and 5-year survival, 78.5 versus 87.2%, 52.4 versus 76.2%, respectively, p = 0.09). Conclusions Although this is a single-center, retrospective analysis of a small number of cardiac sarcoidosis patients who underwent HTx, a concerning trend toward a higher mortality of patients with cardiac sarcoidosis was noted. A careful candidate selection in patients with known cardiac sarcoidosis should be discussed.
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- 2012
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33. Development of a Novel Echocardiography Ramp Test for Speed Optimization and Diagnosis of Device Thrombosis in Continuous-Flow Left Ventricular Assist Devices
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Tomoko S. Kato, Hiroo Takayama, Paolo C. Colombo, Arthur R. Garan, Nir Uriel, Yoshifumi Naka, Farhana Latif, Melana Yuzefpolskaya, Susan Restaino, Kerry A. Morrison, Donna Mancini, M. Flannery, Ulrich P. Jorde, and Ranjit John
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Aortic valve ,medicine.medical_specialty ,Decompression ,Continuous flow ,business.industry ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,equipment and supplies ,medicine.disease ,Thrombosis ,3. Good health ,Transplantation ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Blood pressure ,030228 respiratory system ,Internal medicine ,Ventricular assist device ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,Pump thrombosis ,business - Abstract
Objectives This study sought to develop a novel approach to optimizing continuous-flow left ventricular assist device (CF-LVAD) function and diagnosing device malfunctions. Background In CF-LVAD patients, the dynamic interaction of device speed, left and right ventricular decompression, and valve function can be assessed during an echocardiography-monitored speed ramp test. Methods We devised a unique ramp test protocol to be routinely used at the time of discharge for speed optimization and/or if device malfunction was suspected. The patient's left ventricular end-diastolic dimension, frequency of aortic valve opening, valvular insufficiency, blood pressure, and CF-LVAD parameters were recorded in increments of 400 rpm from 8,000 rpm to 12,000 rpm. The results of the speed designations were plotted, and linear function slopes for left ventricular end-diastolic dimension, pulsatility index, and power were calculated. Results Fifty-two ramp tests for 39 patients were prospectively collected and analyzed. Twenty-eight ramp tests were performed for speed optimization, and speed was changed in 17 (61%) with a mean absolute value adjustment of 424 ± 211 rpm. Seventeen patients had ramp tests performed for suspected device thrombosis, and 10 tests were suspicious for device thrombosis; these patients were then treated with intensified anticoagulation and/or device exchange/emergent transplantation. Device thrombosis was confirmed in 8 of 10 cases at the time of emergent device exchange or transplantation. All patients with device thrombosis, but none of the remaining patients had a left ventricular end-diastolic dimension slope >−0.16. Conclusions Ramp tests facilitate optimal speed changes and device malfunction detection and may be used to monitor the effects of therapeutic interventions and need for surgical intervention in CF-LVAD patients.
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- 2012
34. The effect of tolvaptan on renal excretion of electrolytes and urea nitrogen in patients undergoing coronary artery bypass surgery
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Hiroshi Nakamura, Tomoko S. Kato, Satoshi Matsushita, Mai Murata, Akie Shimada, Atsushi Amano, Hitoshi Suzuki, Yasutaka Yokoyama, Taira Yamamoto, and Kishio Kuroda
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Male ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Urology ,Tolvaptan ,Diuresis ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Blood Urea Nitrogen ,Excretion ,Electrolytes ,03 medical and health sciences ,Coronary artery bypass surgery ,0302 clinical medicine ,Electrolyte ,Internal medicine ,Renal excretion ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Coronary Artery Bypass ,Blood urea nitrogen ,Aged ,Dose-Response Relationship, Drug ,business.industry ,Urea nitrogen ,Benzazepines ,Loop diuretic ,Prognosis ,Renal Elimination ,Renal physiology ,Cardiology ,Female ,Diuretic ,Cardiology and Cardiovascular Medicine ,business ,Antidiuretic Hormone Receptor Antagonists ,Research Article ,Follow-Up Studies ,medicine.drug - Abstract
Adequate fluid management is an important component of patient care following cardiac surgery. Our aim in this study was to determine the benefits of tolvaptan, an oral selective vasopressin-2 receptor antagonist that causes electrolyte-free water diuresis, in postoperative fluid management. We prospectively examined the effect of tolvaptan on renal excretion of electrolytes and urea nitrogen in cardiac surgery patients. Patients undergoing coronary artery bypass surgery were randomized to receive conventional loop diuretics (Group C, n = 30) or conventional loop diuretic therapy plus tolvaptan (Group T, n = 27). Fractional excretions of sodium (FENA), potassium (FEK) and urea nitrogen (FEUN) were measured in both groups during post-surgical hospitalization. Urine output was greater with tolvaptan (Group T) than without it (Group C), and some patients in Group C required intravenous as well as oral loop diuretics. Serum sodium concentrations decreased after surgery in Group C, but were unchanged in Group T (postoperative day [POD] 3, 139.8 ± 3.5 vs. 142.3 ± 2.6 mEq/L, p = 0.006). However, postoperative FENA values in Group C did not decrease, and the values were similar in both groups. Serum potassium levels remained lower and FEK values remained higher than the preoperative values, but only in Group C (all p
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- 2016
35. First Attempt of Sequential Living Donor Liver and Hematopoietic Stem Cell Transplantation in a Child With Advanced Hepatocellular Carcinoma: Case Report
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Prakash Satwani, R. Ramphal, Steven J. Lobritto, Tomoko S. Kato, Joseph A. Picoraro, Nadia Ovchinsky, Mitchell S. Cairo, and Mercedes Martinez
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Oncology ,Male ,medicine.medical_specialty ,Pathology ,Carcinoma, Hepatocellular ,Transplantation Conditioning ,medicine.medical_treatment ,Autopsy ,Hematopoietic stem cell transplantation ,Liver transplantation ,Living donor ,03 medical and health sciences ,Immunocompromised Host ,0302 clinical medicine ,Fatal Outcome ,Internal medicine ,medicine ,Living Donors ,Humans ,Transplantation, Homologous ,Child ,Transplantation ,Neutrophil Engraftment ,business.industry ,Liver Neoplasms ,Hematopoietic Stem Cell Transplantation ,Hematopoietic stem cell ,Immunosuppression ,medicine.disease ,Combined Modality Therapy ,Liver Transplantation ,surgical procedures, operative ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Surgery ,Female ,business ,Toxoplasmosis ,030215 immunology - Abstract
Effective therapeutic options for advanced hepatocellular carcinoma are limited. Hematopoietic stem cell transplantation may offer a graft-versus-tumor effect. Combined liver and hematopoietic stem cell transplantation from the same donor with preparatory conditioning may promote tolerogenicity to the liver allograft and offers the potential for immunosuppression withdrawal. We report our experience with the use of this approach in a pediatric patient with invasive hepatocellular carcinoma and pulmonary metastases who underwent a living-donor liver transplantation followed by reduced-toxicity myeloablative conditioning and hematopoietic stem cell transplant from the same parental donor. Neutrophil engraftment and full donor chimerism was achieved without liver allograft dysfunction. Despite normal liver function and marrow engraftment, the patient succumbed to multisystem organ failure from disseminated toxoplasmosis. At autopsy, there was no histologic evidence of tumor recurrence. No pulmonary nodules were found. Regardless of the unfortunate overall result, this case demonstrates preliminary feasibility of sequential living-donor liver transplantation and hematopoietic stem cell transplantation for unresectable and metastasized hepatic tumors. Future studies in select pediatric patients require evaluation of the optimal conditioning regimen and prevention strategies for opportunistic infections to determine both graft-versus-tumor effect on hepatic tumors and durability of tolerogenicity and possible immunosuppression withdrawal.
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- 2016
36. Relationship of Left Ventricular Diastolic Function to Obesity and Overweight in a Japanese Population With Preserved Left Ventricular Ejection Fraction
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Seitetsu L. Lee, Yoshiko Mizuno, Koichi Kimura, Tsutomu Yamazaki, Masafumi Watanabe, Takayuki Kawata, Tomoko Nakao, Yutaka Yatomi, Marco R. Di Tullio, Tomohiro Shinozaki, Tomoko S. Kato, Megumi Hirokawa, Masao Daimon, Shunichi Homma, and Issei Komuro
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Male ,medicine.medical_specialty ,Diastole ,030204 cardiovascular system & hematology ,Overweight ,Ventricular Function, Left ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Obesity ,Aged ,Heart Failure, Diastolic ,Ejection fraction ,business.industry ,Diastolic heart failure ,Models, Cardiovascular ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,Cross-Sectional Studies ,Echocardiography ,Heart failure ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Body mass index - Abstract
Background Obesity has been found to be associated with future development of diastolic heart failure. Other evidence has indicated that the effect of obesity on left ventricular (LV) mass varies among ethnicities. However, there are few data on the relationship between body mass index (BMI) and LV diastolic dysfunction in the Japanese population. Methods and results We performed echocardiography in 788 subjects without valvular disease or LV systolic dysfunction. They were divided into 3 groups by BMI: normal weight, overweight, and obese. We used multivariable linear regression analysis to assess the clinical variables associated with diastolic parameters, including BMI. We also assessed the risk of diastolic dysfunction associated with BMI using multivariable logistic models. Overweight and obese subjects had significantly worse LV diastolic function and greater LV mass than normal weight subjects. In the multivariable analysis, BMI was independently associated with diastolic parameters. Furthermore, after adjusting for clinical factors, the increased risks of diastolic dysfunction in overweight subjects (adjusted odds ratio: 2.02, 95% confidence interval 1.21-3.36) and obese subjects (4.85, 3.36-16.27) were greater than those previously observed in Western populations. Conclusions The Japanese population might be more susceptible than Western subjects to the effect of BMI on LV diastolic function. Differences between ethnicities should be taken into consideration in strategies for the prevention of diastolic heart failure. (Circ J 2016; 80: 1951-1956).
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- 2016
37. Dynamics and prognostic role of galectin-3 in patients with advanced heart failure, during left ventricular assist device support and following heart transplantation
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Isaac George, D'Vesharronne Moore, Yoshifumi Naka, Ulrich P. Jorde, Ellie J. Coromilas, Hiroo Takayama, Ruiping Ji, Tomoko S. Kato, Raymond C. Givens, Em Claire Que-Xu, Christina Wu, P. Christian Schulze, and Donna M. Mancini
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Male ,Time Factors ,LVAD ,Galectin 3 ,medicine.medical_treatment ,Coronary Allograft Vasculopathy ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Severity of Illness Index ,Ventricular Function, Left ,Coronary artery disease ,0302 clinical medicine ,Galectin-3 ,Medicine ,030212 general & internal medicine ,Heart transplantation ,Blood Proteins ,Middle Aged ,Biomechanical Phenomena ,Cardiac surgery ,Treatment Outcome ,Area Under Curve ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,Research Article ,Adult ,medicine.medical_specialty ,animal structures ,Galectins ,Enzyme-Linked Immunosorbent Assay ,Prosthesis Design ,03 medical and health sciences ,Predictive Value of Tests ,Internal medicine ,Severity of illness ,otorhinolaryngologic diseases ,Humans ,Aged ,Retrospective Studies ,Angiology ,Heart Failure ,business.industry ,medicine.disease ,Myocardial Contraction ,stomatognathic diseases ,ROC Curve ,Heart failure ,Ventricular assist device ,Heart Transplantation ,Heart-Assist Devices ,business ,Biomarkers - Abstract
Background Galectin-3 is a marker of myocardial inflammation and fibrosis shown to correlate with morbidity and mortality in heart failure (HF). We examined the utility of galectin-3 as a marker of the severity of HF, the response of galectin-3 levels to ventricular assist device (LVAD) implantation or heart transplantation (HTx), and its use as a prognostic indicator. Methods Plasma galectin-3 was measured using a commercially available ELISA assay in patients with stable HF (n = 55), severe HF (n = 63), at 3 (n = 17) and 6 (n = 14) months post-LVAD and at LVAD explantation (n = 23), patients following HTx (n = 85) and healthy controls (n = 30). Results Galectin-3 levels increase with the severity of HF (severe HF: 28.2 ± 14, stable HF: 19.7 ± 13, p = 0.001; controls: 13.2 ± 9 ng/ml, p = 0.02 versus stable HF). Following LVAD implantation, galectin-3 levels are initially lower (3 months: 23.7 ± 9, 6 months: 21.7 ± 9 versus 29.2 ± 14 ng/ml implantation; p = NS) but are higher at explantation (40.4 ± 19 ng/ml; p = 0.005 versus pre-LVAD). Galectin-3 levels >30 ng/ml are associated with lower survival post-LVAD placement (76.5 % versus 95.0 % at 2 years, p = 0.009). After HTx, galectin-3 levels are lower (17.8 ± 7.1 ng/ml post-HTx versus 28.2 ± 14 pre-HTx; p
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- 2016
38. Periodontitis and bone metabolism in patients with advanced heart failure and after heart transplantation
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Ulrike, Schulze-Späte, Iman, Mizani, Kristina Rodriguez, Salaverry, Jaime, Chang, Christina, Wu, Meaghan, Jones, Peter J, Kennel, Danielle L, Brunjes, Tse-Hwei, Choo, Tomoko S, Kato, Donna, Mancini, John, Grbic, and P Christian, Schulze
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Bone metabolism ,Original Research Articles ,Heart failure ,Original Research Article ,Periodontal disease - Abstract
Aims Heart failure (HF) is a multiorgan, pro‐inflammatory syndrome that impairs bone metabolism. Pro‐inflammatory cytokines and bone catabolism enhance periodontal disease, a local inflammatory, bacteria‐induced disease that causes bone loss and periodontal soft tissue destruction. Methods and results Medical and dental examinations were performed on patients with HF (n = 39), following heart transplantation (post‐HTx, n = 38) and controls (n = 32). Blood, saliva, and gingival crevicular fluid were analysed for bone metabolism and inflammation markers. HF average New York Heart Association classification was III. Average time since HTx was 1414 days. Pro‐inflammatory tumour necrosis factor‐alpha was higher in HF and HTx as compared with controls (P
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- 2016
39. Factors associated with postoperative requirement of renal replacement therapy following off-pump coronary bypass surgery
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Kenji Kuwaki, Tomoko S. Kato, Yoichiro Machida, Atsushi Amano, and Taira Yamamoto
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Coronary Artery Bypass, Off-Pump ,Renal function ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,Kidney Function Tests ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Postoperative Complications ,Japan ,law ,Risk Factors ,Internal medicine ,Natriuretic Peptide, Brain ,Cardiopulmonary bypass ,Medicine ,Humans ,030212 general & internal medicine ,Hypoalbuminemia ,Renal replacement therapy ,Renal Insufficiency ,Aged ,Aged, 80 and over ,Creatinine ,business.industry ,Odds ratio ,Middle Aged ,medicine.disease ,Brain natriuretic peptide ,Renal Replacement Therapy ,chemistry ,Bypass surgery ,ROC Curve ,Multivariate Analysis ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Cardiopulmonary bypass usage provokes a systemic inflammatory response resulting in deterioration of renal function. However, risk factors for requiring renal replacement therapy (RRT) following off-pump coronary artery bypass graft surgery (CABG) have not yet been fully elucidated. We reviewed 718 consecutive patients undergoing elective off-pump CABG at our institution, excluding patients on chronic hemodialysis preoperatively. Sub-analysis of patients with preserved renal function, defined as a creatinine level below a cut-off value of 1.12 mg/dL (obtained by receiver operating characteristic curve), was also performed. Of the 718 patients, 41 (5.7 %) required RRT. There were 556 patients (77.4 %) with preserved renal function preoperatively, and 13 (2.4 %) of these required postoperative RRT. Multivariate analysis revealed that age (years) and preoperative serum creatinine (mg/dL) and brain natriuretic peptide (BNP) levels (pg/dL) were associated with RRT [odds ratios (OR) 1.052, 95 % confidence interval (CI) 9.064 and 1.001, respectively, all p
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- 2016
40. Cardiac Transplantation in Patients With Hypertrophic Cardiomyopathy
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Donna M. Mancini, P. Christian Schulze, Mathew S. Maurer, Hiroo Takayama, Tomoko S. Kato, Maryjane Farr, Yoshifumi Naka, Charles C. Marboe, and Saeko Yoshizawa
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Adult ,Graft Rejection ,Male ,medicine.medical_specialty ,Heart Diseases ,Heart disease ,medicine.medical_treatment ,Myocardial Ischemia ,Cardiomyopathy ,Ventricular Function, Left ,Cohort Studies ,Internal medicine ,medicine ,Humans ,Survival rate ,Aged ,Retrospective Studies ,Heart transplantation ,business.industry ,Incidence ,Hypertrophic cardiomyopathy ,Retrospective cohort study ,Cardiomyopathy, Hypertrophic ,Middle Aged ,medicine.disease ,Survival Rate ,Transplantation ,Treatment Outcome ,Cardiology ,Heart Transplantation ,Female ,Cardiology and Cardiovascular Medicine ,business ,Immunosuppressive Agents ,Cohort study - Abstract
Cardiac transplantation is a treatment option for patients with hypertrophic cardiomyopathy (HC) who developed refractory heart failure and/or intractable arrhythmia. However, the pretransplant characteristics and post-transplant prognosis for patients with nondilated idiopathic HC has not yet fully elucidated. Therefore, we retrospectively reviewed 813 consecutive transplant recipients undergoing cardiac transplantation at Columbia University Medical Center from 1999 to 2010 and compared the clinical course of 41 patients with idiopathic HC with that of 373 patients with ischemic heart disease and 398 patients with other heart disease. The patients with HC were younger than those with ischemic heart disease (47.8 ± 14.0 vs 57.1 ± 9.4 years; p0.0001). The proportion of patients undergoing ventricular assist devise surgery for bridge-to-transplant was lower in patients with HC than in those with ischemic heart disease or other heart disease (14.6% vs 31.1% vs 35.7%, all p0.01). The post-transplant survival of those with HC was better than that for those with ischemic heart disease (90.1% vs 85.8% and 83.9% vs 67.1% at 1 and 5 years, respectively; p = 0.0359), although it was not significantly different from those with other heart disease. Proportional hazards analysis revealed that the subjects with HC had reduced post-transplant mortality (hazard ratio 0.4760, 95% confidential interval 0.1889 to 0.9762; p = 0.042) on univariate, but not multivariate, analysis. Most patients with HC had nondilated left ventricles (left ventricular end-diastolic dimension ≤ 55 mm; n = 27), and post-transplant survival did not differ from that for those with dilated left ventricles (left ventricular end-diastolic dimension55 mm; n = 14). In conclusion, the post-transplant survival of those with HC did not differ from those of the subjects who underwent transplant for other non-HC indications.
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- 2012
41. Liver dysfunction as a predictor of outcomes in patients with advanced heart failure requiring ventricular assist device support: Use of the Model of End-stage Liver Disease (MELD) and MELD eXcluding INR (MELD-XI) scoring system
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P. Christian Schulze, Jonathan Yang, Tomoko S. Kato, Hiroo Takayama, Maryjane Farr, Donna M. Mancini, Yoshifumi Naka, Ulrich P. Jorde, and B.P. Shulman
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Pulmonary and Respiratory Medicine ,Transplantation ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Cardiomyopathy ,medicine.disease ,body regions ,Liver disease ,Internal medicine ,Heart failure ,Ventricular assist device ,medicine ,Cardiology ,Surgery ,Liver function ,Cardiology and Cardiovascular Medicine ,business ,Liver function tests ,Survival rate - Abstract
Background Liver dysfunction increases post-surgical morbidity and mortality. The Model of End-stage Liver Disease (MELD) estimates liver function but can be inaccurate in patients receiving oral anti-coagulation. We evaluated the effect of liver dysfunction on outcomes after ventricular assist device (VAD) implantation and the dynamic changes in liver dysfunction that occur during VAD support. Methods We retrospectively analyzed 255 patients (147 with pulsatile devices and 108 with continuous-flow devices) who received a long-term VAD between 2000 and 2010. Liver dysfunction was estimated by MELD and MELD-eXcluding INR (MELD-XI), with patients grouped by a score of ≥ 17 or Results MELD and MELD-XI correlated highly ( R ≥ 0.901, p p p = 0.0193). However, if MELD-XI normalized during VAD support, post-transplant survival improved and was similar to that of patients with low MELD-XI scores. Conclusions MELD-XI is a viable alternative for assessing liver dysfunction in heart failure patients on oral anti-coagulation. Liver dysfunction is associated with worse survival. However, if MELD-XI improves during VAD support, post-transplant survival is similar to those without prior liver dysfunction, suggesting an important prognostic role. We also found evidence of a transient cholestatic state after LVAD implantation that deserves further examination.
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- 2012
42. Markers of extracellular matrix turnover and the development of right ventricular failure after ventricular assist device implantation in patients with advanced heart failure
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Jonathan Yang, Hirokazu Akashi, P. Christian Schulze, Tuba Khawaja, Shunichi Homma, Shinichi Iwata, Yoshifumi Naka, Faisal H. Cheema, Donna M. Mancini, Parvati Singh, Aalap Chokshi, Maryjane Farr, Tomoko S. Kato, and Hiroo Takayama
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Male ,Pulmonary and Respiratory Medicine ,Inotrope ,medicine.medical_specialty ,Ventricular Dysfunction, Right ,medicine.medical_treatment ,Matrix metalloproteinase ,Nitric oxide ,Extracellular matrix ,chemistry.chemical_compound ,Internal medicine ,Humans ,Medicine ,Osteopontin ,Retrospective Studies ,Heart Failure ,Transplantation ,Tissue Inhibitor of Metalloproteinase-1 ,Ventricular Remodeling ,biology ,Inhalation ,business.industry ,Tissue Inhibitor of Metalloproteinases ,Middle Aged ,Prognosis ,equipment and supplies ,medicine.disease ,Extracellular Matrix ,Matrix Metalloproteinase 9 ,chemistry ,Heart failure ,Ventricular assist device ,Disease Progression ,biology.protein ,Cardiology ,Matrix Metalloproteinase 2 ,Female ,Surgery ,Heart-Assist Devices ,Matrix Metalloproteinase 1 ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers - Abstract
Cardiac extracellular matrix (ECM) is a dynamic and metabolically active collagenous network that responds to mechanical strain. The association between ECM turnover and right ventricular failure (RVF) development after left ventricular assist device (LVAD) implantation in patients with advanced heart failure (HF) was investigated.Circulating levels of osteopontin, metalloproteinases (MMP)-2 and MPP-9, and tissue inhibitor of MMP (TIMP)-1 and TIMP-4 were measured in 61 patients at LVAD implantation and explantation and in 10 control subjects. RVF was defined as the need for RVAD, nitric oxide inhalation48 hours and/or inotropic support14 days.All ECM markers were elevated in patients with HF compared with controls (all p0.05). RVF developed in 23 patients (37.7%) on LVAD support. All ECM markers decreased on LVAD support in patients without RVF (all p0.05), but serum MMP-2, TIMP-1, TIMP-4, and osteopontin remained elevated in RVF patients. Multivariate analysis identified that right ventricular stroke work index (RVSWI), circulating B-type natriuretic peptide, and osteopontin were associated with RVF (all p0.05). Osteopontin correlated inversely with RVSWI (r = -0.44, p0.001). Osteopontin levels260 ng/ml discriminate patients who develop RVF from those without RVF (sensitivity, 83%; specificity, 82%).Marked elevation of osteopontin levels before LVAD placement is associated with RVF development. Persistent elevation of circulating ECM markers after LVAD implantation characterizes patients who develop RVF. These novel biomarkers would have a potential role in the prediction of RVF development in patients undergoing LVAD implantation.
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- 2012
43. Early Postoperative Outcome of Off-Pump Coronary Artery Bypass Grafting: A Report from the Highest-Volume Center in Japan
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Tomoko S. Kato, Kenji Kuwaki, Kishio Kuroda, Seitetsu L. Lee, Atsushi Amano, Kan Kajimoto, and Taira Yamamoto
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Pulmonary and Respiratory Medicine ,Adult ,Male ,medicine.medical_specialty ,Time Factors ,Databases, Factual ,medicine.medical_treatment ,Coronary Artery Bypass, Off-Pump ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Coronary artery disease ,Cohort Studies ,Hospitals, University ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Japan ,Risk Factors ,Odds Ratio ,Medicine ,Humans ,030212 general & internal medicine ,Hospital Mortality ,Risk factor ,Off-pump coronary artery bypass ,Aged ,Aged, 80 and over ,Ejection fraction ,business.industry ,Mortality rate ,Process Assessment, Health Care ,Gastroenterology ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,Surgery ,surgical procedures, operative ,Treatment Outcome ,Cohort ,Original Article ,Female ,Cardiology and Cardiovascular Medicine ,business ,Hospitals, High-Volume ,Cohort study - Abstract
BACKGROUND Off-pump coronary artery bypass grafting (OPCAB) has evolved into a standard technique in coronary artery bypass grafting. However, a detailed investigation in Japanese population undergoing OPCAB has not yet been fully elucidated. METHODS A total of 1109 consecutive patients undergoing isolated OPCAB between 2006 and 2013 at Juntendo University were reviewed. The data was evaluated in the light of previously published OPCAB-associated reports. RESULTS There were 904 male (81.5%) and a mean was 67.5 ± 9.8 years. Eight patients (0.5%) died within 30 days postoperatively or before discharge, which was equivalent to or rather better than the previously reported mortality rates, including the European System for Cardiac Operation Risk Evaluation II (2.1 ± 2.1) data. A morbidity analysis revealed that prolonged intubation (>24 h) occurred in 43 patients (3.6%), surgical site infections in 18 (1.9%), neurological complications in 13 (1.3%). A reduced preoperative left ventricular ejection fraction (less than 40%) was found to be a risk factor for early postoperative death (odds ratio 10.58, respectively, p
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- 2015
44. Factors influencing left atrial volume in a population with preserved ejection fraction: Left ventricular diastolic dysfunction or clinical factors?
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Seitetsu L. Lee, Masao Daimon, Yoshiko Mizuno, Tsutomu Yamazaki, Masafumi Watanabe, Tomoko Nakao, Tomohiro Shinozaki, Yutaka Yatomi, Megumi Hirokawa, Issei Komuro, Takayuki Kawata, Koichi Kimura, Tomoko S. Kato, and Daniel E. Singer
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Male ,medicine.medical_specialty ,Population ,Diastole ,030204 cardiovascular system & hematology ,Severity of Illness Index ,Body Mass Index ,03 medical and health sciences ,chemistry.chemical_compound ,Hemoglobins ,0302 clinical medicine ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,Mass index ,030212 general & internal medicine ,Heart Atria ,Obesity ,education ,Retrospective Studies ,education.field_of_study ,Creatinine ,Ejection fraction ,business.industry ,Stroke Volume ,Stroke volume ,Middle Aged ,medicine.disease ,Cross-Sectional Studies ,chemistry ,Echocardiography ,Cardiology ,Atrial Function, Left ,Female ,Cardiology and Cardiovascular Medicine ,business ,Body mass index - Abstract
Background Increased left atrial volume (LAV) predicts a higher incidence of cardiovascular events and is widely recognized as a major surrogate marker of left ventricular (LV) diastolic dysfunction (DD). Although the pathophysiology of LA enlargement is probably multifactorial, few studies have examined comprehensively the clinical factors that lead to LA enlargement in the absence of valvular disease or LV systolic dysfunction. Therefore, we investigated associations between LAV and several clinical and echocardiographic parameters including DD. Methods We enrolled 557 subjects without significant valve disease or LV systolic dysfunction from the health check-up clinic retrospectively. We performed univariable and multivariable linear regression using ln LAV index as the dependent variable and the following independent variables: gender, age, smoking status, drinking habit, hypertension, diabetes, body mass index (BMI), LV ejection fraction, DD, LV mass index, hemoglobin, serum creatinine, serum total cholesterol, serum uric acid, serum sodium, and serum iron. Results In multivariable analysis, LAV index was independently associated with BMI, lower hemoglobin, and moderate and severe DD compared with normal diastolic function (p Conclusions LA enlargement was independently associated with moderate and severe DD, but not with mild DD. Furthermore, obesity and lower hemoglobin were associated with LAV independently of DD.
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- 2015
45. Abstract 11813: The Impact of Surgical Left Atrial Appendage Amputation/Ligation on Stroke Prevention in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
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Daisuke Endo, Tomoko S Kato, Tai Iwamura, Akie Shimada, Kan Kajimoto, Shizuyuki Dohi, Kenji Kuwaki, Taira Yamamoto, and Atsushi Amano
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Abstract
Background: Stroke is a major adverse event in patients developing atrial fibrillation (AF) after cardiac surgery. Left atrial appendage (LAA) closure using devices is expected to prevent stroke and enable patients to be warfarin free; however, problems such as procedure-related adverse events and possible residual flow remain unsolved. Concomitant “surgical” LAA amputation/ligation (LAA-A/L) during off-pump coronary artery bypass grafting (OPCAB) is actively performed in our institution. Methods: This is a prospective observational study of 578 consecutive patients (mean age 69 ± 9.8 years, Male 82%) undergoing OPCAB with or without concomitant LAA-A/L from 2011 to 2014. The safety and efficacy of the concomitant procedure, performed on 193 (33%) patients, on preventing early ( Results: LAA was amputated in 154 patients (80%), and ligated in 39 (20%). Between patients with and without LAA-A/L, no difference was seen in the preoperative characteristics including CHADS2 and CHA2DS2-VASc scores, and no significant differences in their operative time, requirement of blood transfusion, length of ICU and total hospital stay were noted. The incidence of postoperative AF was not different (33% vs. 28%, p=0.18), and early and late stroke incidences were not significantly different between the groups (1.0% vs. 0.8%, p=0.75, 2.2% vs. 2.8% p=0.67, respectively). However, in patients without LAA-A/L, both early and late stroke occurred more frequently in those developing AF (2.8% vs. 0%, p=0.005, 6.2% vs. 1.5%; p=0.017, respectively), while stroke incidence in patients receiving LAA-A/L, was not significantly different between those with and without postoperative AF (0.8% vs. 1.6%, p=0.61, 1.6% vs. 2.5%; p=0.69, respectively). Multivariate logistic regression showed postoperative AF without LAA-A/L as the only independent positive predictor of early (OR: 6.8; 95% CI: 1.11 to 52.60; p=0.04) and late (OR: 3.7; 95% CI: 1.18 to 10.94; p=0.03) stroke. Conclusions: Concomitant LAA-A/L with OPCAB is safe and effective for stroke prevention in patients developing postoperative AF. This preventative procedure seems beneficial, since AF is the most common arrhythmia associated with the risk of stroke.
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- 2015
46. Early introduction of tolvaptan after cardiac surgery: a renal sparing strategy in the light of the renal resistive index measured by ultrasound
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Tomoko S. Kato, Shunya Ono, Kenji Kuwaki, Kan Kajimoto, Atsushi Amano, and Taira Yamamoto
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Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,medicine.drug_class ,Urology ,Tolvaptan ,Renal function ,Doppler echocardiography ,Postoperative Complications ,Internal medicine ,Medicine ,Humans ,Renal Insufficiency ,Diuretics ,Infusions, Intravenous ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Cardiovascular Surgical Procedures ,Renal resistive index ,General Medicine ,Loop diuretic ,Cardiac surgery ,Benzazepines ,Middle Aged ,Echocardiography, Doppler ,Discontinuation ,Endocrinology ,Treatment Outcome ,Cardiothoracic surgery ,Surgery ,Female ,business ,Complication ,Cardiology and Cardiovascular Medicine ,Antidiuretic Hormone Receptor Antagonists ,medicine.drug ,Research Article - Abstract
Background Renal failure is a serious complication after cardiac surgery, which can be caused by long-term intravenous (IV) loop diuretic use. Tolvaptan is an oral selective vasopressin-2 receptor antagonist used in patients irresponsive to loop diuretics. We investigated their renal perfusion changes using the resistive index (RI) postoperatively. Methods Serial renal RI, echocardiography, and laboratory examinations from 14 patients requiring continuous postoperative IV loop diuretics were reviewed. Eight patients received tolvaptan (Group T) and six received oral loop diuretics before the discontinuation of IV loop diuretics (Group L). The 1st data were obtained between postoperative day 0 and 2, the 2nd when patients were still under IV loop diuretic treatment, the 3rd after the initiation of tolvaptan or oral loop diuretic, and the 4th after the discontinuation of IV diuretics. Results The 2nd RI value was higher in Group T than Group L (0.77 ± 0.09 vs. 0.69 ± 0.01, p = 0.049) but significantly decreased after tolvaptan administration [0.77 ± 0.09 to 0.65 ± 0.05 (2nd to 3rd), to 0.62 ± 0.04 (to 4th), both p = 0.006], while no such changes were seen in Group L. The serum sodium and albumin levels, and echo-derived tricuspid annular plane systolic excursion increased only in Group T (134.1 ± 1.5 to 138.8 ± 3.2 mEq/L, 3.3 ± 0.3 to 3.7 ± 0.5 g/dL, 16.4 ± 3.6 to 19.7 ± 4.2 mm, all p
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- 2015
47. Left Atrial Appendage Closure Reduces the Incidence of Postoperative Cerebrovascular Accident in Patients Undergoing Cardiac Surgery
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Tai Iwamura, Akie Shimada, Taira Yamamoto, Atsushi Amano, Yasutaka Yokoyama, Daisuke Endo, Atsumi Oishi, Tomoko S. Kato, Kenji Kuwaki, and Hirotaka Inaba
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Postoperative Complications ,Risk Factors ,Internal medicine ,Medicine ,Humans ,Prospective Studies ,Risk factor ,Cardiac Surgical Procedures ,Adverse effect ,Prospective cohort study ,Aged ,business.industry ,Incidence (epidemiology) ,Incidence ,Atrial fibrillation ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,Cardiac surgery ,Surgery ,Amputation ,Cardiovascular Diseases ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
BACKGROUND Cerebrovascular accidents (CVA) are a major adverse event following cardiac surgery, for which atrial fibrillation (AF) is considered as a risk factor. We have recently performed left atrial appendage (LAA) surgical closure or amputation (LAAC/A), which is the main source of emboli, during open-heart surgery. METHODS AND RESULTS A prospective observational study of 1,831 consecutive patients (69.2% male, aged 66.8±12.2 years) undergoing cardiac surgery between 2009 and 2013 was performed. The incidence of postoperative CVA within 6 months in patients with and without LAAC/A was compared. We further stratified patients according to their risk of CVA using CHA2DS2-VASc score; dichotomizing low-risk (score
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- 2015
48. Normalization of Pulmonary Hypertension by the Use of Left Ventricular Assist Device in Patients with End-stage Heart Failure: A Possible Contribution to Donor Pool Expansion in Lung Transplantation
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Hiroo Takayama, Mancini Donna, Yoshifumi Naka, Tomoko S. Kato, Masafumi Kitakaze, Maryjane Farr, Taira Yamamoto, Khurram Shahzad, Atsushi Amano, Hirokazu Akashi, and Kazuhiko Hashimura
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Inotrope ,Heart transplantation ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,lcsh:Geriatrics ,medicine.disease ,Pulmonary hypertension ,Surgery ,lcsh:RC952-954.6 ,medicine.anatomical_structure ,Ventricle ,Heart failure ,Ventricular assist device ,Internal medicine ,pulmonary vascular resistance ,left ventricular assist device ,lung transplantation ,medicine ,Vascular resistance ,Cardiology ,Lung transplantation ,Geriatrics and Gerontology ,business - Abstract
Summary Heart transplantation alone has been recognized to be contraindicated when pulmonary hypertension (PH) and elevated pulmonary vascular resistance (PVR) are irreversible, irrespective of any medical intervention by the use of inotropic agents or pulmonary vasodilators, because such patients are at an increased risk of post-transplantation right ventricular failure and mortality. Therefore, end-stage heart failure patients with concomitant fixed PH and irreversibly high PVR are considered to be heart–lung transplant candidates. Recently, left ventricular assist device (LVAD) therapy has been reported to normalize PVR through persistent unloading of the left ventricle, even in patients with medically refractory PH. Therefore, LVAD therapy could make such patients suitable for “heart-only” transplants, which contributes to appropriate donor lung allocation for lung-only candidates. We review the literature regarding LVAD use for secondary PH and present a case with end-stage heart failure that could avoid a heart–lung transplant owing to LVAD therapy.
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- 2014
49. Clinical Course and Outcome of Heart Transplant Recipients Single Center Experience at the National Cardiovascular Center in Japan
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Hatsue Ishibashi-Ueda, Akihisa Hanatani, Kazuo Komamura, T. Funatsu, Kyoichi Wada, Masanori Asakura, Masafumi Kitakaze, Kazuhiko Hashimura, Akiko Mano, Shuji Hashimoto, Yukiko Nakano, Tomoko S. Kato, Kazuo Niwaya, Yasuki Kihara, Junjiro Kobayashi, and Noboru Oda
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Heart transplantation ,medicine.medical_specialty ,Basiliximab ,business.industry ,medicine.medical_treatment ,General Medicine ,medicine.disease ,Single Center ,Organ transplantation ,Transplantation ,Coronary artery disease ,Regimen ,Internal medicine ,medicine ,Lung transplantation ,Cardiology and Cardiovascular Medicine ,Intensive care medicine ,business ,medicine.drug - Abstract
The number of heart transplant (HTx) surgeries in Japan is expected to increase under the Revised Organ Transplant Law. To date, among 69 HTx surgeries performed in Japan, 27 operations (39.1%) were performed at our institution, the National Cardiovascular Center (NCVC), located in Osaka. We have reviewed the outcomes of HTx conducted at NCVC during a 10 year period (May 1999 to January 2009). Among 27 heart transplant recipients at NCVC, the clinical charts of 26 recipients whose post-HTx period exceeded 1 year were retrospectively reviewed and compared to data from the International Society for Heart and Lung Transplantation (ISHLT) Registry. The survival rate of our recipients was 96.2% at 10.8 years, which was excellent even compared to the ISHLT Registry. The immunosuppressive regimen at NCVC was equivalent to that of the ISHLT Registry, except for more frequent use of Muromonab-CD3 (26.9% versus 3.3%, P < 0.0001) and an initial CSA-based regimen (65.3% versus 34.4%, P < 0.001). The drug we use for induction therapy has been recently changed from Muromonab-CD3 to Basiliximab. The incidences of post-HTx hypertension, diabetes, hyperlipidemia, and renal insufficiency were significantly less in patients at NCVC compared to those in the ISHLT Registry, however, the incidence of transplant coronary artery disease (TxCAD) was almost identical. Clinical review of post-HTx outcome at NCVC can provide useful information for Japanese transplant cardiologists who will engage in HTx management.
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- 2010
50. Cumulative Episodes of Rejection Altered Myocardial Sarcoplasmic Reticulum Ca2+-ATPase and Ryanodine Receptor-2 mRNA Expression in Heart Transplant Recipients
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Masafumi Kitakaze, Hatsue Ishibashi-Ueda, Tomoko S. Kato, Hideo Izawa, Yoshihiko Ikeda, Kazuhiko Hashimura, Taka Aki Matsuyama, Kazuo Komamura, Masaki Asakura, Takeshi Nakatani, Toshiaki Shishido, Mitsuhiro Yokota, Yusuke Sata, and Soichiro Kitamura
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Adult ,Graft Rejection ,Male ,Pathology ,medicine.medical_specialty ,medicine.medical_treatment ,Ryanodine receptor 2 ,Sarcoplasmic Reticulum Calcium-Transporting ATPases ,Cohort Studies ,Young Adult ,Recurrence ,Risk Factors ,Internal medicine ,Biopsy ,Gene expression ,Humans ,Medicine ,Lung transplantation ,RNA, Messenger ,medicine.diagnostic_test ,Reverse Transcriptase Polymerase Chain Reaction ,business.industry ,Ryanodine receptor ,Myocardium ,Endoplasmic reticulum ,Ryanodine Receptor Calcium Release Channel ,General Medicine ,Middle Aged ,Transplantation ,Reverse transcription polymerase chain reaction ,Endocrinology ,Case-Control Studies ,Heart Transplantation ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
The aim of the present study was to investigate the relationship between rejections and gene expression of Ca(2+)-handling proteins in heart transplant recipients. Thirty-seven heart transplant recipients underwent routine endomyocardial biopsy. Levels of sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2) and ryanodine receptor-2 mRNAs in endomyocardial tissue were quantified by a real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) method. Rejections were diagnosed according to the conventional International Society for Heart and Lung Transplantation criteria. Patients were classified as follows; group AR(+) (n = 9) with rejection grade of 2 or higher versus group AR(-) (n = 28) with rejection grade of 0, 1a or 1b at the time of biopsy, and group Rec-AR(+) (n = 6) with a history of more than 4 episodes of treatment required rejection versus group Rec-AR(-) (n = 31) without history of recurrent rejection. The mRNA levels of the SERCA2/GAPDH ratio and ryanodine receptor-2/GAPDH ratio were not different between group AR(+) and group AR(-); however, they were reduced in group Rec-AR(+) more than in group Rec-AR(-) (0.83 +/- 0.07 versus 0.90 +/- 0.07, P = 0.034, 0.74 +/- 0.06 versus 0.84 +/- 0.10, P = 0.027, respectively). A single episode of on-going rejection would not affect myocardial Ca(2+)-handling proteins; however, cumulative rejection episodes might alter the gene expression of myocardial Ca(2+)-handling proteins in heart transplant recipients.
- Published
- 2010
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