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Relationship of Left Ventricular Diastolic Function to Obesity and Overweight in a Japanese Population With Preserved Left Ventricular Ejection Fraction
- Source :
- Circulation journal : official journal of the Japanese Circulation Society. 80(9)
- Publication Year :
- 2016
-
Abstract
- Background Obesity has been found to be associated with future development of diastolic heart failure. Other evidence has indicated that the effect of obesity on left ventricular (LV) mass varies among ethnicities. However, there are few data on the relationship between body mass index (BMI) and LV diastolic dysfunction in the Japanese population. Methods and results We performed echocardiography in 788 subjects without valvular disease or LV systolic dysfunction. They were divided into 3 groups by BMI: normal weight, overweight, and obese. We used multivariable linear regression analysis to assess the clinical variables associated with diastolic parameters, including BMI. We also assessed the risk of diastolic dysfunction associated with BMI using multivariable logistic models. Overweight and obese subjects had significantly worse LV diastolic function and greater LV mass than normal weight subjects. In the multivariable analysis, BMI was independently associated with diastolic parameters. Furthermore, after adjusting for clinical factors, the increased risks of diastolic dysfunction in overweight subjects (adjusted odds ratio: 2.02, 95% confidence interval 1.21-3.36) and obese subjects (4.85, 3.36-16.27) were greater than those previously observed in Western populations. Conclusions The Japanese population might be more susceptible than Western subjects to the effect of BMI on LV diastolic function. Differences between ethnicities should be taken into consideration in strategies for the prevention of diastolic heart failure. (Circ J 2016; 80: 1951-1956).
- Subjects :
- Male
medicine.medical_specialty
Diastole
030204 cardiovascular system & hematology
Overweight
Ventricular Function, Left
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Japan
Internal medicine
medicine
Humans
030212 general & internal medicine
Obesity
Aged
Heart Failure, Diastolic
Ejection fraction
business.industry
Diastolic heart failure
Models, Cardiovascular
General Medicine
Odds ratio
Middle Aged
medicine.disease
Confidence interval
Cross-Sectional Studies
Echocardiography
Heart failure
Cardiology
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Body mass index
Subjects
Details
- ISSN :
- 13474820
- Volume :
- 80
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Circulation journal : official journal of the Japanese Circulation Society
- Accession number :
- edsair.doi.dedup.....223ef6313ff51e07b6f7b1e07ce38233