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1991年から1994年の期間に癌研究会附属病院頭頸科で根治的治療を行なった中咽頭扁平上皮癌は207例であった。このうち121例には一次治療として放射線治療を中心とした保存的治療が行なわれた。一次治療後の局所再発は52例 (43.0%) にみられた。最終的な局所制御率はT1: 100%, T2: 77.7%, T3: 60.6%, T4: 11.1%で, 全体では69.5%であった。手術を中心とした外科的治療を行なった86例の局所制御率は74.2%であった。放射線治療後の再発はT3, T4の症例に頻度が高かったが, T2でも側壁型の下方進展型, 前壁型の喉頭蓋谷への進展が著明な症例にしばしばみられ, 上壁型ではT1, T2の表在性の腫瘍でも再発しやすい傾向があった。Stage 別の疾患特異的5年生存率は stage I: 88.9%, II: 82.2%, III: 73.1%, IV: 36.1%で全体では59.1%であった。

We studied the effects and the timing of tonsillectomy on IgA nephropathy by urinalysis, serum Cr, IgA, ASLO and renal histology. The renal histology was classified into three groups according to its progression.Tonsillectomy was carried out in 31 patients (12 males and 19 females) with IgA nephropathies diagnosed by renal biopsy. The average age at tonsillectomy was 30.4 years old. The effects of tonsillectomy were followed up from more than 1 year (average 36.9 months) after operation. An improvement in urinary findings was observed in 77% and in 22 cases (71%) the tonsillectomy was evaluated as having been effective based on urinary findings and renal function. The difference between the effective group and the ineffective group, in terms of the tonsillectomy, was significant for serum Cr but not for urinary findings, serum IgA or ASLO.The effective rate in groups I and II, based on renal histological classification, was 96%. In group III (advanced stage), no case was considered to show an effective response.We conclude that tonsillectomy in IgA nephropathies should be carried out at an early stage, while renal function is normal and before renal histology has progressed to that of group III.