49 results on '"Tianhu Wang"'
Search Results
2. Pan-mediastinal neoplasm diagnosis via nationwide federated learning: a multicentre cohort study
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Ruijie Tang, PhD, Hengrui Liang, PhD, Yuchen Guo, PhD, Zhigang Li, PhD, Zhichao Liu, MD, Xu Lin, PhD, Zeping Yan, BS, Jun Liu, PhD, Xin Xu, PhD, Wenlong Shao, PhD, Shuben Li, PhD, Wenhua Liang, ProfPhD, Wei Wang, PhD, Fei Cui, PhD, Huanghe He, PhD, Chao Yang, PhD, Long Jiang, PhD, Haixuan Wang, MD, Huai Chen, MD, Chenguang Guo, MD, Haipeng Zhang, MD, Zebin Gao, PhD, Yuwei He, PhD, Xiangru Chen, ME, Lei Zhao, PhD, Hong Yu, MD, Jian Hu, ProfPhD, Jiangang Zhao, MD, Bin Li, PhD, Ci Yin, MD, Wenjie Mao, MD, Wanli Lin, MD, Yujie Xie, MD, Jixian Liu, MD, Xiaoqiang Li, PhD, Dingwang Wu, MD, Qinghua Hou, MD, Yongbing Chen, PhD, Donglai Chen, PhD, Yuhang Xue, MD, Yi Liang, MD, Wenfang Tang, MD, Qi Wang, ProfPhD, Encheng Li, MD, Hongxu Liu, MD, Guan Wang, MD, Pingwen Yu, MD, Chun Chen, ProfPhD, Bin Zheng, PhD, Hao Chen, MD, Zhe Zhang, MD, Lunqing Wang, MD, Ailin Wang, MD, Zongqi Li, MD, Junke Fu, MD, Guangjian Zhang, MD, Jia Zhang, MD, Bohao Liu, MD, Jian Zhao, MD, Boyun Deng, MD, Yongtao Han, PhD, Xuefeng Leng, PhD, Zhiyu Li, MD, Man Zhang, MD, Changling Liu, MD, Tianhu Wang, MD, Zhilin Luo, MD, Chenglin Yang, MD, Xiaotong Guo, MD, Kai Ma, MD, Lixu Wang, MD, Wenjun Jiang, MD, Xu Han, MD, Qing Wang, MD, Kun Qiao, MD, Zhaohua Xia, MD, Shuo Zheng, MD, Chenyang Xu, MD, Jidong Peng, MD, Shilong Wu, MD, Zhifeng Zhang, MD, Haoda Huang, MD, Dazhi Pang, MD, Qiao Liu, BSN, Jinglong Li, MD, Xueru Ding, MD, Xiang Liu, MD, Liucheng Zhong, MD, Yutong Lu, MD, Feng Xu, PhD, Qionghai Dai, ProfPhD, and Jianxing He, ProfPhD
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Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Summary: Background: Mediastinal neoplasms are typical thoracic diseases with increasing incidence in the general global population and can lead to poor prognosis. In clinical practice, the mediastinum's complex anatomic structures and intertype confusion among different mediastinal neoplasm pathologies severely hinder accurate diagnosis. To solve these difficulties, we organised a multicentre national collaboration on the basis of privacy-secured federated learning and developed CAIMEN, an efficient chest CT-based artificial intelligence (AI) mediastinal neoplasm diagnosis system. Methods: In this multicentre cohort study, 7825 mediastinal neoplasm cases and 796 normal controls were collected from 24 centres in China to develop CAIMEN. We further enhanced CAIMEN with several novel algorithms in a multiview, knowledge-transferred, multilevel decision-making pattern. CAIMEN was tested by internal (929 cases at 15 centres), external (1216 cases at five centres and a real-world cohort of 11 162 cases), and human–AI (60 positive cases from four centres and radiologists from 15 institutions) test sets to evaluate its detection, segmentation, and classification performance. Findings: In the external test experiments, the area under the receiver operating characteristic curve for detecting mediastinal neoplasms of CAIMEN was 0·973 (95% CI 0·969–0·977). In the real-world cohort, CAIMEN detected 13 false-negative cases confirmed by radiologists. The dice score for segmenting mediastinal neoplasms of CAIMEN was 0·765 (0·738–0·792). The mediastinal neoplasm classification top-1 and top-3 accuracy of CAIMEN were 0·523 (0·497–0·554) and 0·799 (0·778–0·822), respectively. In the human–AI test experiments, CAIMEN outperformed clinicians with top-1 and top-3 accuracy of 0·500 (0·383–0·633) and 0·800 (0·700–0·900), respectively. Meanwhile, with assistance from the computer aided diagnosis software based on CAIMEN, the 46 clinicians improved their average top-1 accuracy by 19·1% (0·345–0·411) and top-3 accuracy by 13·0% (0·545–0·616). Interpretation: For mediastinal neoplasms, CAIMEN can produce high diagnostic accuracy and assist the diagnosis of human experts, showing its potential for clinical practice. Funding: National Key R&D Program of China, National Natural Science Foundation of China, and Beijing Natural Science Foundation.
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- 2023
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3. Molecular characteristics of multiple primary pulmonary nodules under a three-dimensional reconstruction model and relevant multi-omics analyses: a case report
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Zhilin Luo, Yajie Xiao, Chengwen Luo, Liping Zhang, Runquan Zhou, Zhikun Zhao, Chao Sun, Dongfang Wu, and Tianhu Wang
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multiple primary lung cancer ,multi-omics analyses ,genomic profiling ,tumor environment ,three-dimensional (3D) reconstruction ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
BackgroundIn addition to CT images and pathological features, many other molecular characteristics remain unknown about multiple primary lung cancer (MPLC) from intrapulmonary metastatic lung cancer.Case presentationIn this study, we reported a patient with an early-stage MPLC with both adenocarcinoma in situ (AIS) subtype and minimally invasive adenocarcinoma (MIA) subtype. The patient was diagnosed with more than 10 nodules and underwent precise surgery assisted by three-dimensional (3D) reconstruction at the left upper lung lobe. Whole-exome sequencing (WES) and multiple immunohistochemistry (mIHC) were performed to reveal the genomic profiling and tumor microenvironments of multiple nodules in this patient with MPLC. Based on 3D reconstruction location information, we found that the genomic and pathological results of adjacent lymph nodes were quite different. On the other hand, PD-L1 expression and the proportion of infiltrating lymphocytes in tumor microenvironments were all at a low status and did not vary in adjacent lymph nodes. Additionally, maximum diameter and tumor mutational burden levels were found to be significantly associated with CD8+ T cell proportion (p
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- 2023
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4. Rupture of contralateral mainstem bronchus during uniportal video-assisted thoracoscopy surgery lobectomy and 3 successful cases of repair
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Zhilin Luo, Tianhu Wang, and Hong Zhang
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Uniportal VATS ,Bronchial rupture ,Repair ,Surgery ,RD1-811 ,Anesthesiology ,RD78.3-87.3 - Abstract
Abstract Background Our goal was to discuss the treatment for rupture of contralateral mainstem bronchus during uniportal video-assisted thoracoscopy surgery (uniportal VATS) lobectomy. Case presentation We analyzed clinical data of 3 cases of rupture of contralateral mainstem bronchus during uniportal VATS. Surgical repair was performed immediately under an uniportal VATS during operation, as a result, 3 cases of bronchial rupture all were repaired successfully, and we continued to complete lobectomy and systemic lymph node dissection. Reexamination was performed after 1 week, and no fistula was found in trachea and bronchi through a fiberoptic bronchoscopy. The time range for indwelling the chest tube is 6–9 days, and the hospital stay is 8–10 days. No abnormality was observed on chest radiography when the 3 patients returned to the hospital 1 month after the operation for the second reexamination. Conclusions Instant surgical repair is recommended to the treatment of bronchial rupture in thoracic surgery. It is safe and feasible to repair bronchial tear with uniportal VATS.
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- 2021
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5. Epidemiological Evidence Between Variants in Matrix Metalloproteinases-2, -7, and -9 and Cancer Risk
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Chenglu Huang, Suqin Xu, Zhilin Luo, Dong Li, Rui Wang, and Tianhu Wang
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matrix metalloproteinases ,variant ,meta-analysis ,gene ,cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
BackgroundMatrix metalloproteinases (MMPs), a kind of proteases, have a critical function in cancer occurrence, invasion, and migration. MMP gene variants (e.g., MMP-2, MMP-7, and MMP-9) can affect the biological functions of these enzymes and lead to the occurrence and progression of cancer, which has become a hot topic in recent years, but the corresponding results are still controversial. In this context, here, the meta-analysis was conducted for assessing the relations of variants in MMP-2, MMP-7, and MMP-9 with the risk of various cancers.MethodsPubMed, Web of Science, and Medline were systemically searched, and data were extracted from all eligible studies so as to investigate the susceptibility of MMP-2, MMP-7, and MMP-9 to different types of cancers. The association between a variant in MMP and cancer susceptibility was analyzed through odds ratios (ORs) as well as 95% CIs. The Venice criteria and false-positive report probability (FPRP) were adopted to evaluate epidemiological evidence of significant associations discovered.ResultsThe associations between the variants of MMPs and cancer risk in 36,530 cases and 41,258 controls were found, with 12 associations (MMP-2 rs243865 with esophageal cancer and lung cancer, MMP-7 rs11568818 with bladder and cervical cancer, and MMP-9 rs3918242 with breast cancer) rated as strong associations for cancer risk and 7 and 15 as moderate and weak associations, respectively. These significant associations were mostly found in Asians.ConclusionsThese findings support the relations between variants of MMP-2, MMP-7, and MMP-9 and various cancers risk, demonstrating the credibility of these relations.
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- 2022
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6. Alteration of N6-Methyladenosine mRNA Methylation in a Human Stem Cell-Derived Cardiomyocyte Model of Tyrosine Kinase Inhibitor-Induced Cardiotoxicity
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Yan Ma, Xian Liu, Yiming Bi, Tianhu Wang, Cheng Chen, Yabin Wang, Dong Han, and Feng Cao
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tyrosine kinase inhibitor (TKI) ,hiPSC-CMs ,N6-methyladenosine ,FTO ,cardiotoxicity ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundN6-methyladenosine (m6A) plays important roles in various cardiovascular diseases (CVDs), including cardiac hypertrophy and heart failure. Sunitinib (SUN) is a tyrosine kinase inhibitor (TKI) that is widely used in the treatment of different types of solid and blood tumors, but its efficacy is restricted by a concomitant rise in cardiotoxicities. However, the methylation modification of m6A messenger RNA (mRNA) in cardiomyocytes treated with TKI has not been investigated.MethodsThe global m6A methylation level of SUN-induced cardiotoxicity was detected by m6A dot blot and colorimetric methylation assay. MeRIP-Seq (methylated RNA immunoprecipitation sequencing) and RNA-seq (RNA sequencing, input) were employed to depict the landscapes of transcriptome and epitranscriptome in TKI. Changes in major m6A-related enzymes were detected by qRT-PCR and Western blot. In addition, the effects of FTO on SUN-induced cardiotoxicity were evaluated by gain and loss of function studies.ResultsIn this study, we observed that the m6A methylation level was significantly elevated in SUN-treated human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and paralleled a positively correlated cellular damage level. Through a genome-wide analysis of m6A mRNA methylation by methylated RNA immunoprecipitation sequencing (MeRIP-seq) and input RNA sequencing (RNA-seq), we identified a total of 2,614 peaks with significant changes, of which 1,695 peaks were significantly upregulated and 919 peaks were significantly downregulated. Quantitative reverse transcription PCR (RT-qPCR), immunofluorescence, and Western blotting revealed that the RNA demethylase fat mass and obesity-associated protein (FTO) was downregulated, whereas the RNA methylases methyltransferase-like 14 (METTL14) and wilms' tumor 1-associating protein (WTAP) were upregulated. Furthermore, gain- and loss-of-function studies substantiated that FTO is cardioprotective in TKI.ConclusionThis study deciphered the methylation modification of m6A mRNA in hiPSC-CMs post-TKI treatment and determined that FTO may be a promising therapeutic target for TKI-induced cardiotoxicity.
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- 2022
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7. Principle, Fabrication and Emerging Applications of Nanobottle Motor
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Qingyuan Liu, Lin Wang, Kaiying Wang, Tianhu Wang, and Guohua Liu
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nanobottle ,propulsion ,nanomotors ,energy ,environment ,biomedicine ,Technology - Abstract
Micro/nano-motors play an important role in energy, environment, and biomedicines. As a new type of nano-motors, nanobottles attract great attention due to their distinct advantages of a large cavity, high specific surface area, bionic streamline structure, and chemotactic motion. Here, we systematically review the development of nanobottle motors from aspects of propulsion mechanisms, fabrication methods and potential applications. Firstly, three types of propulsive modes are summarized, with focus on chemical propulsion, light driving and magnetic actuation. We then discuss the fabrication methods of nanobottles, including the soft-template-based hydrothermal method and the swelling-inducement and wet-chemistry methods. The potential applications of nanobottle motors are additionally highlighted in energy, environmental, and biomedical fields. Finally, the future challenges and outlooks of nanobottle motors are discussed for the further development of this technology.
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- 2022
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8. Zearalenone-Induced Mechanical Damage of Intestinal Barrier via the RhoA/ROCK Signaling Pathway in IPEC-J2 Cells
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Biying Huang, Jingjing Wang, Aixin Gu, Tianhu Wang, Jianping Li, and Anshan Shan
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zearalenone ,RhoA/ROCK pathway ,intestinal barrier ,IPEC-J2 cells ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Zearalenone (ZEN) is a widespread contaminant of cereals and agricultural products which causes food safety issues. Ingesting food or feed contaminated with ZEN can disrupt the intestinal epithelial barrier function. The RhoA/ROCK signaling pathway plays a key role in regulating the epithelial barrier function, but studies on such roles have rarely focused on the intestine. The aim of this experiment was to investigate the exact mechanism of ZEN-induced intestinal barrier damage and whether the RhoA/ROCK signaling pathway is involved. The results showed that ZEN significantly induced alkaline phosphatase (AP) activity and FITC–dextran (4 kDa) passage across the epithelial barrier, which significantly reduced the transepithelial resistance (TEER). Meanwhile, ZEN could induce the significantly down-regulated mRNA expression of tight junction proteins (occludin, claudin-1, ZO-1, and claudin-3) and redistribution of ZO-1 immunofluorescence. Further studies demonstrated that ZEN exposure activated the RhoA/ROCK signaling pathway, significantly up-regulated the mRNA expression of ROCK1, the main effector of the signaling pathway, the protein expression of phosphorylated myosin light chain (MLC) and myosin light chain kinase (MLCK), and relatively increased the activity of ATP in cells, simultaneously remodeling the cytoskeleton (F-actin). Overall, our study indicated that ZEN induced intestinal barrier dysfunction by activating the RhoA/ROCK signaling pathway.
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- 2022
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9. Integrative Analysis of HTNV Glycoprotein Derived MHC II Epitopes by In Silico Prediction and Experimental Validation
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Hao Sun, Zhenhua Lu, Guoyun Xuan, Ning Liu, Tianhu Wang, Yang Liu, Mingfu Lan, Jiahao Xu, Yuancai Feng, Shuang Xu, Yuchen Lu, Baozeng Sun, Jinpeng Zhang, Xiyang Zhang, Yuanjie Sun, Shuya Yang, Yun Zhang, Yusi Zhang, Linfeng Cheng, Dongbo Jiang, and Kun Yang
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Hantaan virus glycoprotein ,major histocompatibility complex II epitope ,in silico prediction ,enzyme-linked immunospot assay ,pan-major histocompatibility complex reaction ,Microbiology ,QR1-502 - Abstract
Hantaan virus (HTNV), the causative pathogen of hemorrhagic fever with renal syndrome (HFRS), is a negative RNA virus belonging to the Orthohantaviridae family. HTNV envelope glycoprotein (GP), encoded by the genomic medium segment, is immunogenic and is therefore a promising vaccine candidate. Major histocompatibility complex class I (MHC-I) epitopes derived from HTNV has been extensively studied, but little is known of MHC-II epitopes. In silico predictions based on four databases indicated that the full-length HTNV GP has 1121 15-mer epitopes, of which 289 had a high score for binding to the human and murine MHC-II superfamily. It found that epitope ILTVLKFIANIFHTS could potentially bind most MHC-II molecules covering human and murine haplotypes. Dominant epitopes were validated by enzyme-linked immunospot assay of splenocytes from immunized mice; 6 of 10 epitopes supported the predictions including TATYSIVGPANAKVP, TKTLVIGQCIYTITS, FSLLPGVAHSIAVEL, CETYKELKAHGVSCP, CGLYLDRLKPVGSAY, and NLGENPCKIGLQTSS. Conservation analysis of dominant epitopes revealed host–virus interactions without geographic stratification, thus meeting the requirements of candidate vaccines for large-population prophylaxis. These findings provide insight into hantavirus antigenicity and suggest that vaccines targeting MHC-II could provide immune protection in large population to complement symptomatic therapies for the treatment of HFRS.
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- 2021
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10. Durable Response to Immunotherapy With Antiangiogenic Drug in Large-Cell Lung Carcinoma With Multiple Fulminant Postoperative Metastases: A Case Report
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Zhilin Luo, Hong Zhang, Yajie Xiao, Rui Wang, Liping Zhang, Chenglu Huang, Yu Cao, Chao Sun, Yongtian Zhao, Hanqing Lin, Dongfang Wu, and Tianhu Wang
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large-cell lung carcinoma ,multiple postoperative metastases ,loss of heterozygosity at HLA ,immunotherapy ,antiangiogenic drugs ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Immunotherapy alone or chemo-immunotherapy has recently been recommended for treating advanced lung carcinoma in patients without driver mutations. However, the efficacy of immunotherapy and molecular mechanism in large-cell lung cancer (LCLC) remains unclear. Here, we reported a rare case of multiple fulminant postoperative body and mouth metastases in LCLC treating with combination immunotherapy. Initially, the patient was diagnosed as early stage LCLC and underwent a radical resection of the right lower lobe. Just one month later, multiple fulminant body and mouth lesions appeared in the right upper arm, right elbow, right waist, and tongue root. Meanwhile, serum neuron specific enolase (NSE) concentration dramatically increased from 12.12 to 30.14 ng/ml. Immumohistochemistry findings demonstrated moderate PD-L1 expressions with tumor proportion score (TPS), while next-generation sequencing indicated moderate tumor mutational burden (TMB) levels and gene mutations in PBRM1 L1230P and TP53 L194R of both foci. Besides, loss of heterozygosity (LOH) at human leukocyte antigen (HLA) class I (HLA-A*02:03, HLA-B*55:02 and HLA-C*12:03) were detected in the right upper arm metastasis, which may facilitate malignant postoperative metastases in this case. Notably, this patient received combination therapy with anti-PD-1 antibody sintilimab plus anlotinib, and achieved a partial response for at least 12 months. Using an integrated computational method, the mutant peptide TEIPENDIPL derived from PBRM1 L1230P was predicted to be a specific neoantigen and could still be presented by HLA-B*40:01. This case suggests that immunotherapy plus antiangiogenic drug may provide an alternative therapeutic option for advanced LCLC patients without common gene mutations.
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- 2021
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11. The Antagonistic Effect of Glutamine on Zearalenone-Induced Apoptosis via PI3K/Akt Signaling Pathway in IPEC-J2 Cells
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Tianhu Wang, Jingjing Wang, Tong Zhang, Aixin Gu, Jianping Li, and Anshan Shan
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zearalenone ,glutamine ,PI3K/Akt pathway ,apoptosis ,IPEC-J2 cells ,Medicine - Abstract
Zearalenone (ZEN) is a non-steroidal estrogen mycotoxin produced by Fusarium fungi, which inevitably exists in human and animal food or feed. Previous studies indicated that apoptosis seems to be a key determinant of ZEN-induced toxicity. This experiment aimed to investigate the protective effects of Glutamine (Gln) on ZEN-induced cytotoxicity in IPEC-J2 cells. The experimental results showed that Gln was able to alleviate the decline of cell viability and reduce the production of reactive oxygen species and calcium (Ca2+) induced by ZEN. Meanwhile, the mRNA expression of antioxidant enzymes such as glutathione reductase, glutathione peroxidase, and catalase was up-regulated after Gln addition. Subsequently, Gln supplementation resulted in the nuclear fission and Bad-fluorescence distribution of apoptotic cells were weakened, and the mRNA expression and protein expression of pro-apoptotic genes and apoptotic rates were significantly reduced. Moreover, ZEN reduced the phosphorylation Akt, decreased the expression of Bcl-2, and increased the expression of Bax. Gln alleviated the above changes induced by ZEN and the antagonistic effects of Gln were disturbed by PI3K inhibitor (LY294002). To conclude, this study revealed that Gln exhibited significant protective effects on ZEN-induced apoptosis, and this effect may be attributed to the PI3K/Akt signaling pathway.
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- 2021
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12. A three dimensional study of upper airway in adult skeletal Class II patients with different vertical growth patterns.
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Tianhu Wang, Zhenhua Yang, Fang Yang, Mingye Zhang, Jinlong Zhao, Jinwu Chen, and Yongming Li
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Medicine ,Science - Abstract
OBJECTIVE: The study was performed to compare the 3D pharyngeal airway dimensions in adult skeletal Class II patients with different vertical growth patterns (low, normal, and high angle) and to investigate whether the upper airway dimensions of untreated skeletal Class II adults were affected by vertical skeletal variables. METHODS: Cone-beam computed tomography (CBCT) records of 64 untreated adult skeletal Class II patients (34 male and 30 female) were collected to evaluate the pharyngeal airway dimensions. Subjects were divided into three subgroups according to the GoGn-SN angle (low angle, normal angle or high angle). All subgroups were matched for sex. ANOVA and SNK-q tests were used to identify differences within and among groups (p
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- 2014
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13. Thermal Performance of Mini Cooling Channels for High-Power Servo Motor with Non-Uniform Heat Dissipation
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Tianhu Wang, Zhigang Gao, Junhua Bai, Zhiqiang Wang, Keqiang Qiao, and Peng Li
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Condensed Matter Physics - Published
- 2023
14. The Association between the Risk of Esophageal Cancer and Type 2 Diabetes Mellitus: An Updated Meta-Analysis
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Runquan Zhou, Chenglu Huang, Zhilin Luo, and Tianhu Wang
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Article Subject ,Esophageal Neoplasms ,Diabetes Mellitus, Type 2 ,General Immunology and Microbiology ,Risk Factors ,Humans ,Esophageal Squamous Cell Carcinoma ,General Medicine ,Adenocarcinoma ,General Biochemistry, Genetics and Molecular Biology - Abstract
Background. A large amount of publications had reported the association between incidence of esophageal cancer (EC) and type 2 diabetes mellitus (T2DM) in the past decade. However, those papers’ results are inconsistent on relationships between T2DM the incidence of EC. Therefore, the objective of this meta-analysis was to determine the relationship between T2DM and the risk of EC (including 2 histological types, esophageal adenocarcinoma [EADC] and esophageal squamous cell carcinoma [ESCC]). Method. We finally extracted 19 articles though Pubmed, Embased, and Cochrane library. Those identify extraction date including 14,312 cases and 24,959,067 control records and then mixed the relative risks (RRs) and corresponding 95% confidence intervals (95%CIs) through STATA. Results. We observed that there are significantly positive correlation between T2DM and EC risk ( R R = 1.28 , 95% CI: 1.05-1.57, P = 0.015 ).Also, our study showed positive correlation between T2DM and EADC (esophageal adenocarcinoma) risk ( R R = 1.28 , 95% CI: 1.05-1.57, P < 0.001 ). What’s more, subgroup analysis based on ethnicity represented the Caucasian is more susceptible to EC ( R R = 1.28 ,95% CI: 1.10-1.49, P = 0.001 ). Conclusion. Those results offer a recent epidemiological and integrated evidence to ascertain the correlations between T2DM and incidence of EC. Those results take public health implications on preventing T2DM and then depress the occurrence of EC. Our study also provides referenced information for the prevention. However, some data is still insufficient, and more research should be carried out.
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- 2022
15. Thermal performance investigation of supercritical methane in minichannel heat sink on flight vehicle actuator under geometry effect of cross section
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Zhigang Gao, Tianhu Wang, Junhua Bai, Zhiqiang Wang, Keqiang Qiao, and Peng Li
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Numerical Analysis ,Condensed Matter Physics - Published
- 2022
16. Complete response to first-line osimertinib monotherapy in a complex epidermal growth factor receptor mutant (L833V/H835L) lung adenocarcinoma patient
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Zhilin Luo, Chengwen Luo, Runquan Zhou, Yajie Xiao, and Tianhu Wang
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Pharmacology ,Cancer Research ,Oncology ,Pharmacology (medical) - Published
- 2023
17. Salvianolic Acid B Suppresses Non-Small-Cell Lung Cancer Metastasis through PKM2-Independent Metabolic Reprogramming
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Hong Zhang, Jianming Tang, Yu Cao, and Tianhu Wang
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Article Subject ,Complementary and alternative medicine ,parasitic diseases - Abstract
Objective. Salvianolic acid B (Sal B) has been demonstrated to be a potential chemoprevention agent for several cancers. Herein, we investigated the pharmacological function of Sal B on non-small-cell lung cancer (NSCLC) metastasis. Methods. Two NSCLC cell lines (NCI-H2030 and NCI-H1650) were disposed of by 200 μM Sal B or 10 μM PKM2 agonist TEPP-46. Wound healing and transwell experiments were implemented for analyzing migratory and invasive capacities. Epithelial-to-mesenchymal transition (EMT) markers β-catenin and E-cadherin were measured via western blotting. Cellular bioenergetics were evaluated with glucose uptake, lactate production, enolase activity, cellular ATP levels, as well as seahorse-based oxygen consumption rate (OCR), extracellular acidification rate (ECAR) analysis. Metabolic reprogramming markers PKM2, LDHA, and GLUT1 were detected via western blotting and immunofluorescence. Results. The results showed that Sal B disposal weakened the migration and invasion of NCI-H2030 and NCI-H1650 cells and inactivated the EMT process according to downregulation of β-catenin and upregulation of E-cadherin. Sal B-treated NSCLC cells displayed decreased glucose uptake, lactate production, enolase activity, cellular ATP levels, OCR, and ECAR, indicating a reduction in metabolic reprogramming. Additionally, Sal B downregulated the expression of PKM2, LDHA, and GLUT1. TEPP-46 may reverse the inhibitory effect of Sal B on metastasis as well as metabolic reprogramming. Conclusion. Our findings provide evidence that Sal B enables to weaken NSCLC metastasis through PKM2-independent metabolic reprogramming, which sheds light on the promising therapeutic usage of Sal B in treating NSCLC.
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- 2022
18. Research on the Switching Characteristics Based on the SiC MOSFET Model
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Wenjie, Li, primary, Tianhu, Wang, additional, Yang, Zhao, additional, Baoqiang, Wang, additional, Qiannian, Miu, additional, Yunzhe, Shen, additional, Rong, Wang, additional, and Hongcheng, Chu, additional
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- 2023
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19. Tumor immune microenvironment predicts the pathologic response of neoadjuvant chemoimmunotherapy in non–small‐cell lung cancer
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Rui Han, Yimin Zhang, Tianhu Wang, Hualiang Xiao, Zhilin Luo, Cheng Shen, Jianghua Li, Chenglong Zhao, Li Li, Mengxiao Zhu, Haiwei Du, Huan Tang, Zheng Ma, Yubo Wang, and Yong He
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Cancer Research ,Oncology ,General Medicine - Published
- 2023
20. Molecular characteristics of multiple primary pulmonary nodules under a threedimensional reconstruction model and relevant multi-omics analyses: a case report.
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Zhilin Luo, Yajie Xiao, Chengwen Luo, Liping Zhang, Runquan Zhou, Zhikun Zhao, Chao Sun, Dongfang Wu, and Tianhu Wang
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PULMONARY nodules ,MULTIOMICS ,TUMOR-infiltrating immune cells ,COMPUTED tomography ,LUNG cancer - Abstract
Background: In addition to CT images and pathological features, many other molecular characteristics remain unknown about multiple primary lung cancer (MPLC) from intrapulmonary metastatic lung cancer. Case presentation: In this study, we reported a patient with an early-stage MPLC with both adenocarcinoma in situ (AIS) subtype and minimally invasive adenocarcinoma (MIA) subtype. The patient was diagnosed with more than 10 nodules and underwent precise surgery assisted by three-dimensional (3D) reconstruction at the left upper lung lobe. Whole-exome sequencing (WES) and multiple immunohistochemistry (mIHC) were performed to reveal the genomic profiling and tumor microenvironments of multiple nodules in this patient with MPLC. Based on 3D reconstruction location information, we found that the genomic and pathological results of adjacent lymph nodes were quite different. On the other hand, PD-L1 expression and the proportion of infiltrating lymphocytes in tumor microenvironments were all at a low status and did not vary in adjacent lymph nodes. Additionally, maximum diameter and tumor mutational burden levels were found to be significantly associated with CD8+ T cell proportion (p<0.05). Besides, CD163+ macrophages and CD4+ T cell proportion were higher in MIA nodules than in AIS nodules (p<0.05). This patient reached a recurrence-free survival of 39 months. Conclusion: Generally, in addition to CT imaging and pathological results, genomic profiling and tumor microenvironments may facilitate identifying the potential molecular mechanisms and clinical outcomes in patients with earlystage MPLC. [ABSTRACT FROM AUTHOR]
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- 2023
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21. Ruptura del bronquio principal contralateral durante lobectomía por cirugía toracoscópica videoasistida uniportal, y tres casos de reparación exitosa
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Zhilin Luo, Tianhu Wang, and Hong Zhang
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Antecedentes: Nuestro objetivo es discutir el tratamiento para la ruptura del bronquio principal contralateral durante una lobectomía por cirugía toracoscópica videoasistida uniportal (VATS uniportal). Presentación de casos: Analizamos los datos clínicos de tres casos de ruptura del bronquio principal contralateral durante la VATS uniportal. La reparación quirúrgica se realizó inmediatamente bajo la VATS uniportal durante la operación; como resultado, tres casos de ruptura bronquial se repararon exitosamente, y se continuó hasta completar la lobectomía y la disección de nódulo linfático sistémico. Los casos se reexaminaron una semana después, y no se encontró fístula en la tráquea ni en los bronquios por broncoscopía con fibra óptica. El rango de permanencia de la sonda pleural fue 6–9 días, y la estancia hospitalaria fue de 8–10 días. No se observaron anormalidades en la radiografía torácica cuando las tres pacientes regresaron al hospital un mes después de la operación para una segunda revaloración. Conclusiones: Se recomienda la reparación quirúrgica instantánea para el tratamiento de la ruptura bronquial en la cirugía torácica. Reparar un desgarre bronquial con VATS uniportal es seguro y factible.
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- 2021
22. Heat Transfer Analysis of Supercritical Methane in Microchannels With Different Geometric Configurations on High Power Electromechanical Actuator
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Zhigang Gao, Tianhu Wang, Yuxin Yang, Xiaolong Shang, Junhua Bai, and Peng Li
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Mechanics of Materials ,Electrical and Electronic Engineering ,Computer Science Applications ,Electronic, Optical and Magnetic Materials - Abstract
The issue of regenerative cooling is one of the most important key technologies of flight vehicles, which is applied into both the engine and high-power electrical equipment. One pattern of regenerative cooling channels is the microchannel heat sinks, which are thought as a prospective means of improving heat removal capacities on electrical equipment of smaller sizes. In this paper, three numerical models with different geometric configurations, namely, straight, zigzag, and sinusoid, respectively, are built to probe into the thermal hydraulic performance while heat transfer mechanism of supercritical methane in microchannel heat sinks for the heat removal of high-power electromechanical actuator is also explored. In addition, some crucial influence factors on heat transfer such as inlet Reynolds number, operating pressure, and heating power are investigated. The calculation results imply the positive effect of wavy configurations on heat transfer and confirm the important effect of buoyancy force of supercritical methane in channels. The heat sinks with wavy channel show obvious advantages on comprehensive thermal performance including overall thermal performance parameter η and thermal resistance R compared with that of the straight one. The highest Nu and average heat transfer coefficient αm appear in the heat sink with zigzag channels, but the pumping power of the heat sink with sinusoidal channels is lower due to the smaller flow loss.
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- 2022
23. Simulation of Indoor Pseudolite Positioning Accuracy Based on EKF
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Tao Huang, Yunzhe Shen, Junxian Zhang, Wenjuan Gu, and Tianhu Wang
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- 2022
24. Transcription factor NFIC functions as a tumor suppressor in lung squamous cell carcinoma progression by modulating lncRNA CASC2
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Hong Zhang, Zhilin Luo, JianMing Tang, Jie Tian, Yajie Xiao, Chao Sun, and Tianhu Wang
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Lung Neoplasms ,Tumor Suppressor Proteins ,Cell Biology ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,NFI Transcription Factors ,Carcinoma, Non-Small-Cell Lung ,Cell Line, Tumor ,Carcinoma, Squamous Cell ,Humans ,Genes, Tumor Suppressor ,RNA, Long Noncoding ,Molecular Biology ,Lung ,Developmental Biology ,Cell Proliferation ,Research Paper - Abstract
Nuclear factor I (NFI) family is emerging found playing oncogenic or tumor-suppressive potential in cancers. However, the function and underlying mechanisms of NFIC, in the progression of Lung Squamous Cell Carcinoma (LUSC) remain unclear. Therefore, this study aims to probe into the function of NFIC in the development of LUSC. In the present study, we reported that NFIC was low expressed in human LUSC tissues and cell lines. NFIC inhibited LUSC cell proliferation and promoted cell apoptosis in vitro and in vivo. Moreover, NFIC also inhibited LUSC cell migration and invasion. Furthermore, we found that there were binding sites between lncRNA cancer susceptibility candidate 2 (CASC2) and NFIC, whose relationship was confirmed by the luciferase reporter assay. The expression of CASC2 and the expression of NFIC were positively correlated, and the function of CASC2 overexpression is similar to that of NFIC overexpression, which suggested that CASC2 may play a key role in LUSC development. Our study provided a new perspective for NFIC acting as an antioncogene in LUSC tumorigenesis, and NFIC and CASC2 may serve as novel potential targets for the treatment of LUSC.
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- 2022
25. Alteration of N
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Yan, Ma, Xian, Liu, Yiming, Bi, Tianhu, Wang, Cheng, Chen, Yabin, Wang, Dong, Han, and Feng, Cao
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NThe global mIn this study, we observed that the mThis study deciphered the methylation modification of m
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- 2022
26. Tumor Immune Microenvironment Predicts the Pathologic Response Of Neoadjuvant Chemoimmunotherapy In Locally Advanced And Oligometastatic Non–Small Cell Lung Cancer
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Rui Han, Yimin Zhang, Tianhu Wang, Hualiang Xiao, Zhilin Luo, Cheng Shen, Jianghua Li, Chenglong Zhao, Li Li, Mengxiao Zhu, Haiwei Du, Zheng Ma, Yubo Wang, and Yong He
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History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
27. Tendon Distribution Optimization Method of Prestressed Concrete Bridges Based on Consistent Safety Degree of Stress Index
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Tianhu Wang, Dong Xu, and Shengbin Wang
- Abstract
The traditional tendon distribution method of prestressed concrete bridges is mainly based on trial calculation. The existing optimization research of structure and tendon distribution mostly takes the least material consumption or total economy as the optimization goal, but the stress of the structure may not be reasonable. Therefore, considering the rationality of structural stress, the optimization method has a large research space. This paper puts forward the tendon distribution optimization method for the prestressed concrete bridge. This method takes the principle that the safety degree of stress indexes at different positions of the whole bridge is as consistent as possible. On the premise of meeting the codes and construction feasibility, this method realizes the optimization of the amount of prestressed steel tendons in the bridge. Finally, a three-span continuous bridge is used as the optimization example to verify the rationality and feasibility of the method.
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- 2022
28. Expert consensus on resection of chest wall tumors and chest wall reconstruction
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Lei Wang, Hiroaki Kuroda, Luming Wang, Shugeng Gao, Gaoming Xiao, Guofang Zhao, Shumin Wang, Ricciardi Sara, Ting Ye, Jing Li, Dong Wang, He-Cheng Li, Hans Van Veer, Jun Chen, Yuming Zhu, Lijun Huang, Mingqiang Kang, Nai-Quan Mao, Daqiang Sun, Tianhu Wang, Luca Ampollini, Andrea Bille, Qun Wang, Masatsugu Hamaji, Jinbo Zhao, Jian Li, Xiao-Fei Li, Wen-Zhao Zhong, Yongtao Han, Jacopo Vannucci, Beatrice Aramini, Jin Yong Jeong, Guangjian Zhang, Ge-Ning Jiang, Cecilia Pompili, Tao Jiang, Hong Mei, Shuben Li, Wen-Jie Jiao, Tiesheng Cao, Ke-Neng Chen, Junqiang Fan, Ilhan Inci, Xuefeng Leng, Linyou Zhang, Alberto Sandri, Zhigang Li, Lunxu Liu, Erik R. de Loos, Inderpal S. Sarkaria, Giuseppe Marulli, Fabio Davoli, Shao-Min Li, Ming-Wu Chen, Karel W.E. Hulsewé, Chang Chen, Jinliang Yang, Shiping Guo, Hui Guo, Zsolt Sziklavari, Hongjing Jiang, Chaoyang Liang, Chaozong Liu, Yuichiro Ueda, Alfonso Fiorelli, Hongbin Duan, Xiaolong Yan, Servet Bölükbas, Yvonne L. J. Vissers, Jun Zhao, Shidong Xu, Wei Guo, Zhongcheng Li, Chun Chen, Junke Fu, and Lei Wang , Xiaolong Yan, Jinbo Zhao, Chang Chen, Chun Chen, Jun Chen, Ke-Neng Chen, Tiesheng Cao, Ming-Wu Chen, Hongbin Duan, Junqiang Fan, Junke Fu, Shugeng Gao, Hui Guo, Shiping Guo, Wei Guo, Yongtao Han , Ge-Ning Jiang , Hongjing Jiang, Wen-Jie Jiao, Mingqiang Kang, Xuefeng Leng, He-Cheng Li, Jing Li, Jian Li, Shao-Min Li, Shuben Li, Zhigang Li, Zhongcheng Li, Chaoyang Liang, Nai-Quan Mao, Hong Mei, Daqiang Sun, Dong Wang, Luming Wang, Qun Wang, Shumin Wang, Tianhu Wang, Lunxu Liu, Gaoming Xiao, Shidong Xu, Jinliang Yang, Ting Ye, Guangjian Zhang, Linyou Zhang, Guofang Zhao, Jun Zhao, Wen-Zhao Zhong, Yuming Zhu, Karel W E Hulsewé, Yvonne L J Vissers, Erik R de Loos, Jin Yong Jeong, Giuseppe Marulli, Alberto Sandri, Zsolt Sziklavari , Jacopo Vannucci, Luca Ampollini, Yuichiro Ueda , Chaozong Liu , Andrea Bille , Masatsugu Hamaji, Beatrice Aramini, Ilhan Inci , Cecilia Pompili, Hans Van Veer, Alfonso Fiorelli, Ricciardi Sara, Inderpal S Sarkaria, Fabio Davoli, Hiroaki Kuroda, Servet Bölükbas, Xiao-Fei Li, Lijun Huang , Tao Jiang Affiliations expand
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medicine.medical_specialty ,Consensus ,business.industry ,Expert consensus ,chest wall reconstruction ,excision margin ,medicine.disease ,Resection ,Chest wall reconstruction ,chest wall tumor ,radiotherapy ,Consensus, resection, chest wall tumors, chest wall reconstruction ,Oncology ,medicine ,Radiology ,Lung cancer ,business - Abstract
Chest wall tumors are a relatively uncommon disease in clinical practice. Most of the published studies about chest wall tumors are usually single-center retrospective studies, involving few patients. Therefore, evidences regarding clinical conclusions about chest wall tumors are lacking, and some controversial issues have still to be agreed upon. In January 2019, 73 experts in thoracic surgery, plastic surgery, science, and engineering jointly released the Chinese Expert Consensus on Chest Wall Tumor Resection and Chest Wall Reconstruction (2018 edition). After that, numerous experts put forward new perspectives on some academic issues in this version of the consensus, pointing out the necessity to further discuss the points of contention. Thus, we conducted a survey through the administration of a questionnaire among 85 experts in the world. Consensus has been reached on some major points as follows. (I) Wide excision should be performed for desmoid tumor (DT) of chest wall. After excluding the distant metastasis by multi-disciplinary team, solitary sternal plasmacytoma can be treated with extensive resection and adjuvant radiotherapy. (II) Wide excision with above 2 cm margin distance should be attempted to obtain R0 resection margin for chest wall tumor unless the tumor involves vital organs or structures, including the great vessels, heart, trachea, joints, and spine. (III) For patients with chest wall tumors undergoing unplanned excision (UE) for the first time, it is necessary to carry out wide excision as soon as possible within 1-3 months following the previous surgery. (IV) Current Tumor Node Metastasis staging criteria (American Joint Committee on Cancer) of bone tumor and soft tissue sarcoma are not suitable for chest wall sarcomas. (V) It is necessary to use rigid implants for chest wall reconstruction once the maximum diameter of the chest wall defect exceeds 5 cm in adults and adolescents. (VI) For non-small cell lung cancer (NSCLC) invading the chest wall, wide excision with neoadjuvant and/or adjuvant therapy are recommended for patients with stage T3-4N0-1M0. As clear guidelines are lacking, these consensus statements on controversial issues on chest wall tumors and resection could possibly serve as further guidance in clinical practice during the upcoming years. ispartof: TRANSLATIONAL LUNG CANCER RESEARCH vol:10 issue:11 pages:4057-4083 ispartof: location:China status: published
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- 2021
29. Tanshinone IIA Reverses Gefitinib-Resistance In Human Non-Small-Cell Lung Cancer Via Regulation Of VEGFR/Akt Pathway
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Hong Zhang, Rui Wang, Zhilin Luo, and Tianhu Wang
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0301 basic medicine ,integumentary system ,Chemistry ,Caspase 3 ,medicine.disease ,respiratory tract diseases ,Blot ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Gefitinib ,Oncology ,Downregulation and upregulation ,Apoptosis ,030220 oncology & carcinogenesis ,medicine ,Cancer research ,Cytotoxic T cell ,heterocyclic compounds ,Pharmacology (medical) ,skin and connective tissue diseases ,Lung cancer ,neoplasms ,PI3K/AKT/mTOR pathway ,medicine.drug - Abstract
Background Gefitinib-resistance is a primary obstacle for the treatment of non-small-cell lung cancer (NSCLC). It has been shown that tanshinone IIA (Tan IIA) could induce apoptosis of NSCLC cells. However, the role of combination of gefitinib with Tan IIA on gefitinib-resistance NSCLC cells remains unclear. Thus, this study aimed to investigate the role of combination on the proliferation, apoptosis and invasion of gefitinib-resistance NSCLC cells. Methods CCK-8, flow cytometric and transwell assays were applied to detect proliferation, apoptosis and invasion in gefitinib-resistance NSCLC cells, respectively. In addition, Western blotting assay was used to detect the expressions of p-EGFR, p-VEGFR2, and p-Akt in HCC827/gefitinib cells. Results In this study, Tan IIA enhanced the cytotoxic effect of gefitinib in gefitinib-resistance NSCLC cells. In addition, the inhibitory effects of gefitinib on the proliferation, migration and invasion of gefitinib-resistance NSCLC cells were enhanced in the presence of Tan IIA. Moreover, Tan IIA enhanced the pro-apoptotic effect of gefitinib in gefitinib-resistance NSCLC cells via increasing the level of cleaved caspase 3. Meanwhile, Tan IIA enhanced the sensitivity of HCC827/gefitinib cells to gefitinib via downregulation of the VEGFR2/Akt pathway. In vivo experiments further confirmed that combination of gefitinib with Tan IIA inhibited tumor growth in mouse xenograft model of HCC827/gefitinib. Conclusion We found that Tan IIA could enhance gefitinib sensitivity in gefitinib-resistance NSCLC cells. Therefore, combination of gefitinib with Tan IIA might be considered as a therapeutic approach for the treatment of gefitinib-resistant NSCLC.
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- 2019
30. Accelerometer-based human fall detection using sparrow search algorithm and back propagation neural network
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Tianhu Wang, Baoqiang Wang, Yunzhe Shen, Yang Zhao, Wenjie Li, Keming Yao, Xiaojie Liu, and Yinsheng Luo
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Applied Mathematics ,Electrical and Electronic Engineering ,Condensed Matter Physics ,Instrumentation - Published
- 2022
31. Research on a quality detection system of dust suppression spraying for railway coal transportation using laser backscattering technology
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Tianhu Wang, Yuntao Wu, Yang Zhao, Yinsheng Luo, and Yongjie Wang
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Condensed Matter Physics ,Instrumentation ,Industrial and Manufacturing Engineering ,Atomic and Molecular Physics, and Optics - Abstract
Aiming at the low efficiency of manual sample inspection of dust suppression spraying quality in railway coal transportation, a detection system combining a high-pressure gas spraying and laser backscattering detection technology is presented in this paper. In terms of hardware, it is composed of gas excitation, powdered coal concentration detection and a control unit. The gas excitation device, including nozzle, camera and electric control platform, is designed for realizing the dust suppressant spraying quality detection by nozzle jet gas impacts on a coal surface. In terms of software, the programs for the system were developed based on the LabVIEW development platform, realizing the system parameter adjustment, detection signal display, gas excitation control and real-time data storage functions. Experimental results show that the gas pressure of the field test should be maintained at 0.9 MPa–1.23 MPa and the distance between the equipment and the target vehicle is more than 2000 mm. The proposed system can detect 3–4 times spot checks with a single carriage for the train under the speed of 3 m s−1–5 m s−1, which solves the problems of low efficiency and high risk of manual detection.
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- 2022
32. Tubeless video-assisted thoracic surgery for pulmonary ground-glass nodules: expert consensus and protocol (Guangzhou)
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Jianxing He, Hengrui Liang, Wei Wang, Andrey Akopov, Alberto Aiolfi, Keng-Leong Ang, Luca Bertolaccini, Kaican Cai, Qingdong Cao, Baojun Chen, Chang Chen, Chun Chen, Donglai Chen, Fengxia Chen, Jun Chen, Lei Chen, Mingwu Chen, Yongbing Chen, Zhuxing Chen, Chao Cheng, Dong Cui, Fei Cui, Tianyang Dai, Qinglong Dong, Paolo A. Ferrari, Raja M. Flores, Junke Fu, Soichiro Funaki, Marios E. Froudarakis, Xiangfeng Gan, Mingfei Geng, Jialong Guo, Qiang Guo, Yongtao Han, Jintao He, Kaiming He, Kyoji Hirai, Jian Hu, Shuqiao Hu, Jian Huang, Jun Huang, Wenfa Jiang, Kyung Soo Kim, Gabor Kiss, Fanyi Kong, Lan Lan, Xuefeng Leng, Bin Li, Gaofeng Li, Hecheng Li, Hefei Li, Heng Li, Jiwei Li, Xiaoqiang Li, Shuben Li, Yinfen Li, Zhuoyi Li, Yi Liang, Lixia Liang, Wenhua Liang, Yongde Liao, Wanli Lin, Xu Lin, Hongxu Liu, Hui Liu, Jixian Liu, Jun Liu, Xiang Liu, Zihao Liu, Xingzhao Lu, Qingquan Luo, Naiquan Mao, Qi Pan, Dazhi Pang, Jun Peng, Eugenio Pompeo, Rulin Qian, Kun Qiao, Bassam Redwan, Zi Sang, Wenlong Shao, Jianfei Shen, Weiyu Shen, Sook-Whan Sung, Wenfang Tang, Tianhu Wang, Guangsuo Wang, Haitao Wang, Huien Wang, Jiyong Wang, Wen Wang, Yongyong Wang, Zhenyuan Wang, Li Wei, Wei Wei, Hao Wu, Jie Wu, Zhaohua Xia, Chenyang Xu, Enwu Xu, Hai Xu, Ning Xu, Quan Xu, Rongyu Xu, Shun Xu, Chaokun Yang, Hanyu Yang, Shengli Yang, Jun Yi, Guangjian Zhang, Hao Zhang, Jia Zhang, Man Zhang, Xiao Zhang, Yajie Zhang, Zhe Zhang, Zhifeng Zhang, Honglin Zhao, Jian Zhao, Xiaodong Zhao, Jianping Zhou, Yanran Zhou, Chengchu Zhu, Shaojin Zhu, Xinhai Zhu, Jian Cui, Yubo Yan, and Ke-Neng Chen
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Protocol (science) ,medicine.medical_specialty ,Consensus ,business.industry ,General surgery ,MEDLINE ,Expert consensus ,medicine.disease ,Oncology ,Video assisted thoracic surgery ,Settore MED/21 ,medicine ,Lung cancer ,business - Published
- 2021
33. Durable Response to Immunotherapy With Antiangiogenic Drug in Large-Cell Lung Carcinoma With Multiple Fulminant Postoperative Metastases: A Case Report
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Tianhu Wang, Dongfang Wu, Yu Cao, Hanqing Lin, Zhilin Luo, Yajie Xiao, Chao Sun, Rui Wang, Chenglu Huang, Liping Zhang, Hong Zhang, and Yongtian Zhao
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Oncology ,Cancer Research ,medicine.medical_specialty ,Combination therapy ,medicine.medical_treatment ,Fulminant ,loss of heterozygosity at HLA ,Case Report ,Gene mutation ,Metastasis ,multiple postoperative metastases ,Internal medicine ,medicine ,Carcinoma ,antiangiogenic drugs ,Lung cancer ,large-cell lung carcinoma ,RC254-282 ,business.industry ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Immunotherapy ,medicine.disease ,Large-cell lung carcinoma ,immunotherapy ,business - Abstract
Immunotherapy alone or chemo-immunotherapy has recently been recommended for treating advanced lung carcinoma in patients without driver mutations. However, the efficacy of immunotherapy and molecular mechanism in large-cell lung cancer (LCLC) remains unclear. Here, we reported a rare case of multiple fulminant postoperative body and mouth metastases in LCLC treating with combination immunotherapy. Initially, the patient was diagnosed as early stage LCLC and underwent a radical resection of the right lower lobe. Just one month later, multiple fulminant body and mouth lesions appeared in the right upper arm, right elbow, right waist, and tongue root. Meanwhile, serum neuron specific enolase (NSE) concentration dramatically increased from 12.12 to 30.14 ng/ml. Immumohistochemistry findings demonstrated moderate PD-L1 expressions with tumor proportion score (TPS), while next-generation sequencing indicated moderate tumor mutational burden (TMB) levels and gene mutations in PBRM1 L1230P and TP53 L194R of both foci. Besides, loss of heterozygosity (LOH) at human leukocyte antigen (HLA) class I (HLA-A*02:03, HLA-B*55:02 and HLA-C*12:03) were detected in the right upper arm metastasis, which may facilitate malignant postoperative metastases in this case. Notably, this patient received combination therapy with anti-PD-1 antibody sintilimab plus anlotinib, and achieved a partial response for at least 12 months. Using an integrated computational method, the mutant peptide TEIPENDIPL derived from PBRM1 L1230P was predicted to be a specific neoantigen and could still be presented by HLA-B*40:01. This case suggests that immunotherapy plus antiangiogenic drug may provide an alternative therapeutic option for advanced LCLC patients without common gene mutations.
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- 2021
34. Successful Operation Following Neoadjuvant Immunotherapy Combined with Chemotherapy for Right Aortic Arch with Esophageal Cancer: A Case Report
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Tianhu Wang, Dong Li, and Zhilin Luo
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Aortic arch ,Chemotherapy ,medicine.medical_specialty ,Successful operation ,business.industry ,medicine.medical_treatment ,medicine.artery ,medicine ,Immunotherapy ,Esophageal cancer ,business ,medicine.disease ,Surgery - Abstract
Background Right aortic arch (AAA) with esophageal cancer is a kind of rare case. Tumor shrinkage after neoadjuvant immunotherapy combined with chemotherapy and subsequently successful excision of the esophageal tumor under minimally invasive surgery are reported for this case in this paper.Case presentation The patient was a 50-year-old man who was diagnosed with AAA and esophageal cancer with a clinical stage of c-T3N1M0, stage III. Because Computed tomography(CT) indicated a larger volume of the tumor with signs of outward invasion, along with vascular malformations, neoadjuvant immunotherapy combined with neoadjuvant chemotherapy was given. After 3 cycles of neoadjuvant therapy, this patient achieved a fully clinical symptom remission, and re-examination result of chest CT showed tumor shrinkage, so a minimally invasive surgery was provided to remove the tumor. Following the surgery, immunotherapy and chemotherapy were continued.Conclusion For locally advanced esophageal cancer with vascular malformations, neoadjuvant therapy is a good treatment option. If achieving downstaging, the tumor would be well removed just with a minimally invasive surgery.
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- 2021
35. Spectral Properties of the Interaction Between Hesperidin of Tangerine Peel’s Active Ingredient with Protein
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Yuxia Sun, Hu Yue, Chen Tianyu, and Tianhu Wang
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Pharmacology ,Active ingredient ,Hesperidin ,chemistry.chemical_compound ,chemistry ,Spectral properties ,Food science ,Tangerine Peel - Published
- 2018
36. Prognostic value of long noncoding RNA urothelial carcinoma-associated 1 in esophageal carcinoma: A protocol for meta-analysis, TCGA data and bioinformatics analysis
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Hong Zhang, TianHu Wang, Jianming Tang, and Jie Tian
- Subjects
Oncology ,medicine.medical_specialty ,Esophageal Neoplasms ,MEDLINE ,urothelial carcinoma associated 1 ,Disease-Free Survival ,03 medical and health sciences ,0302 clinical medicine ,Esophagus ,Meta-Analysis as Topic ,Internal medicine ,Protein Interaction Mapping ,Study Protocol Systematic Review ,Carcinoma ,Biomarkers, Tumor ,Medicine ,Humans ,030212 general & internal medicine ,Protein Interaction Maps ,esophageal cancer ,long noncoding RNAs ,KEGG ,business.industry ,Mechanism (biology) ,Hazard ratio ,Computational Biology ,General Medicine ,Esophageal cancer ,medicine.disease ,Prognosis ,Long non-coding RNA ,Gene Expression Regulation, Neoplastic ,meta-analysis ,030220 oncology & carcinogenesis ,Meta-analysis ,RNA, Long Noncoding ,business ,Systematic Reviews as Topic ,Research Article - Abstract
Background: Currently, an increasing number of long noncoding RNAs (LncRNAs) have been reported to be abnormally expressed in human carcinomas and play a vital role in tumourigenesis. Some studies have been carried out to investigate the influence of the expression of LncRNA human urothelial carcinoma associated 1 (UCA1) on prognosis and clinical significance in patients with esophageal cancer, but the results are contradictory and uncertain. A meta-analysis and was conducted with controversial data to accurately assess the issue. We collected relevant TCGA data to further testify the result. In addition, bioinformatics analysis was conducted to investigate the mechanism and related pathways of LncRNA UCA1 in esophageal carcinoma. Methods: Wanfang, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure, the Chongqing VIP Chinese Science and Technology Periodical Database, PubMed, Embase, and Web of Science were thoroughly searched for relevant information. Two reviewers independently performed data extraction and literature quality evaluation. Odd ratio and its 95% confidence intervals were applied to evaluate the relationship between LncRNA UCA1 and clinicopathological characteristics of esophageal carcinoma patients. Hazard ratios and its 95% confidence intervals were adopted to assess the prognostic effects of LncRNA UCA1 on overall survival and disease-free survival. Meta-analysis was performed with Stata 14.0 software. To further assess the function of LncRNA UCA1 in esophageal carcinoma, relevant data from The Cancer Genome Atlas (TCGA) database was collected. Three databases, miRWalk, TargetScan, and miRDB, were used for prediction of target genes. Genes present in these 3 databases were considered as predicted target genes of LncRNA UCA1. Venny 2.1 were used for intersection analysis. Subsequently, GO, KEGG, and PPI network analysis were conducted based on the overlapping target genes of LncRNA UCA1 to explore the possible molecular mechanism in esophageal carcinoma. Results: This study provides a high-quality medical evidence for the correlation between LncRNA UCA1 expression and overall survival, and between disease-free survival and clinicopathological features. Based on bioinformatics analysis, this study enhanced the understanding of the mechanism and related pathways of LncRNA UCA1 in esophageal carcinoma. Conclusion: The study provides updated evidence to evaluate whether the expression of LncRNA UCA1 is in association with poor prognosis in patients with esophageal carcinoma. Ethics and dissemination The private information from individuals will not be published. This systematic review also should not damage participants’ rights. Ethical approval is not available. The results may be published in a peer-reviewed journal or disseminated in relevant conferences. OSF Registration Number: DOI 10.17605/OSF.IO/8MCHW.
- Published
- 2021
37. A multicenter single-arm trial of sintilimab in combination with chemotherapy for neoadjuvant treatment of resectable esophageal cancer (SIN-ICE study)
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Liping Tong, Jianqun Ma, Honggang Liu, Ory Wiesel, Xiaoyuan Wang, Biniam Kidane, Zhilin Luo, Michele Valmasoni, Khaldoun Almhanna, Xiaolong Yan, Yong Zhang, Tianhu Wang, Hongtao Duan, Sainan Pang, and Xiaoping Dong
- Subjects
Oncology ,safety ,medicine.medical_specialty ,Chemotherapy ,major pathological response (MPR) ,business.industry ,medicine.medical_treatment ,efficacy ,pathological complete response (pCR) ,General Medicine ,Esophageal cancer ,medicine.disease ,Sintilimab ,Neoadjuvant treatment ,Internal medicine ,medicine ,Original Article ,business - Abstract
BACKGROUND: Preoperative chemotherapy or chemoradiotherapy is the standard treatment for resectable esophageal cancer (EC); however, it is associated with increased postoperative complications and mortality. Recently, Immune Checkpoint inhibitors have been incorporated in the treatment of advanced EC. Its role in the preoperative setting has not been established yet. In this multicenter, single-arm study, we evaluated the efficacy and safety of neoadjuvant therapy with sintilimab in combination with chemotherapy in treating EC. METHODS: Patients received neoadjuvant therapy with 3 cycles of sintilimab 200 mg Q3W in combination with platinum-based chemotherapy. Surgery was performed within 4–6 weeks after neoadjuvant therapy. The primary endpoints of the trial were pathological complete response (pCR) and safety. RESULTS: A total of 23 patients (21 men and 2 women) were enrolled. Surgery was completed in 17 participants, with 16 achieving R0 resection and 1 had R1 resection, 5 participants refused surgery. One patient progressed prior to surgery. Twenty one patients (91%) had significant improvement in their dysphagia following treatment as assessed by Stooler’s criteria. The majority of patients who underwent resection have a good pathological response and downstaging rate was 76.5% (13/17). A pCR was achieved in 6 cases (6/17, 35.3%) and major pathological response (MPR) in 9 cases (9/17, 52.9%). The main preoperative adverse events (AEs) were vomiting (13/23, 56.5%), leukopenia (12/23, 52.2%), neutropenia (9/23, 39.1%), and malaise (8/23, 34.8%). Immune-related AEs were mild and included hypothyroidism (2/23, 8.7%) and rash (4/23, 17.4%). The incidence of ≥ grade 3 treatment related AEs was 30.4% (7/23). There were no ≥ grade 4 AEs. CONCLUSIONS: Sintilimab in combination with chemotherapy in the neoadjuvant treatment of EC is safe and lead to a high pCR. Therefore, further testing is warranted.
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- 2021
38. Characteristics of Oral Microbiota in Patients with Esophageal Cancer in China
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Hezi Li, Zhilin Luo, Hong Zhang, Nali Huang, Dong Li, Chengwen Luo, and Tianhu Wang
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Male ,China ,General Immunology and Microbiology ,Esophageal Neoplasms ,Article Subject ,Microbiota ,General Medicine ,Middle Aged ,General Biochemistry, Genetics and Molecular Biology ,stomatognathic diseases ,Case-Control Studies ,RNA, Ribosomal, 16S ,Humans ,Medicine ,Esophageal Squamous Cell Carcinoma ,Research Article ,Aged - Abstract
Gut microbiota dysbiosis is closely associated with intestinal carcinogenesis, but the oral microbiota of patients with esophageal squamous cell carcinoma who live in high-risk regions in China has not been fully characterized. In the current study, oral microbial diversity was investigated in 33 patients with esophageal squamous cell carcinoma and 35 healthy controls in Chongqing, China, by sequencing 16S rRNA of V3-V4 gene regions. There were statistically significant differences in oral microbiota between esophageal squamous cell carcinoma patients and controls as determined via unweighted pair-group analysis with arithmetic means. At the phylum level, in esophageal squamous cell carcinoma patients, there were comparatively greater amounts of Firmicutes (34.0% vs. 31.1%) and Bacteroidetes (25.3% vs. 24.9%) and lower amounts of Proteobacteria (17.0% vs. 20.1%). At the genus level, esophageal squamous cell carcinoma patients exhibited comparatively greater amounts of Streptococcus (17.3% vs. 14.5%) and Prevotella_7 (8.6% vs. 8.5%) and lower amounts of Neisseria (8.1% vs. 10.7%). Using a linear discriminant analysis effect size method, Planctomycetes and Verrucomicrobia were identified in the esophageal squamous cell carcinoma group. 10 genera were higher abundances identified in the healthy control group, and different 10 genera were identified in the esophageal squamous cell carcinoma group. In the present study, there were significant differences in oral microbial compositions of esophageal squamous cell carcinoma patients and healthy controls. Further longitudinal and mechanistic studies are needed to further characterize relationships between oral microbiota and esophageal squamous cell carcinoma.
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- 2021
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39. Voltage-gated sodium channels: structures, functions, and molecular modeling
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Tingjun Hou, Xiaoqin Ding, Huiyong Sun, Tianhu Wang, Lei Xu, and Shanzhi Mou
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0301 basic medicine ,Pharmacology ,Models, Molecular ,Binding Sites ,Molecular model ,Molecular Structure ,Chemistry ,Sodium channel ,Voltage-Gated Sodium Channels ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Drug Discovery ,Animals ,Humans ,Neuralgia ,Neuroscience - Abstract
Voltage-gated sodium channels (VGSCs), formed by 24 transmembrane segments arranged into four domains, have a key role in the initiation and propagation of electrical signaling in excitable cells. VGSCs are involved in a variety of diseases, including epilepsy, cardiac arrhythmias, and neuropathic pain, and therefore have been regarded as appealing therapeutic targets for the development of anticonvulsant, antiarrhythmic, and local anesthetic drugs. In this review, we discuss recent advances in understanding the structures and biological functions of VGSCs. In addition, we systematically summarize eight pharmacologically distinct ligand-binding sites in VGSCs and representative isoform-selective VGSC modulators in clinical trials. Finally, we review studies on molecular modeling and computer-aided drug design (CADD) for VGSCs to help understanding of biological processes involving VGSCs.
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- 2019
40. Exploring electrolyte preference of vanadium nitride supercapacitor electrodes
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Gang Lu, Bo Wang, Tianhu Wang, Zhaohui Chen, and Yun-wang Ge
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Supercapacitor ,Materials science ,Lithium vanadium phosphate battery ,Mechanical Engineering ,Vanadium nitride ,Inorganic chemistry ,Vanadium ,chemistry.chemical_element ,02 engineering and technology ,Electrolyte ,Nitride ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Electrochemistry ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Mechanics of Materials ,Pentoxide ,General Materials Science ,0210 nano-technology - Abstract
Vanadium nitride hierarchical nanostructures were prepared through an ammonia annealing procedure utilizing vanadium pentoxide nanostructures grown on graphite foam. The electrochemical properties of hierarchical vanadium nitride was tested in aqueous and organic electrolytes. As a result, the vanadium nitride showed better capacitive energy storage property in organic and alkaline electrolytes. This work provides insight into the charge storage process of vanadium nitride and our findings can shed light on other transition metal nitride-based electrochemical energy storage systems.
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- 2016
41. Free-Standing Porous Carbon Nanofiber Networks from Electrospinning Polyimide for Supercapacitors
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Qiu-Ping Luo, Tianhu Wang, Bo Wang, and Gang Lu
- Subjects
Supercapacitor ,Horizontal scan rate ,Materials science ,Article Subject ,Carbonization ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Capacitance ,Electrospinning ,0104 chemical sciences ,Nanofiber ,lcsh:Technology (General) ,Electrode ,lcsh:T1-995 ,General Materials Science ,Composite material ,0210 nano-technology ,Polyimide - Abstract
Free-standing porous carbon nanofiber networks (CFNs) were synthesized by electrospinning method and carbonization procedure. We study the implementation of porous CFNs as supercapacitor electrodes and electrochemical measurements demonstrated that porous CFNs exhibit a specific capacitance (205 F/g at the scan rate of 5 mV/s) with high flexibility and good rate capability performance (more than 70% of its initial capacitance from 5 mV/s to 200 mV/s). Furthermore, porous CFNs exhibited an excellent cycling stability (just 12% capacitance loss after 10,000 cycles). These results suggest that porous CFNs are very promising candidates as flexible supercapacitor electrodes.
- Published
- 2016
42. Study on Interaction of Drug to Bovine Serum Albumin and Serum by UV-Visible Spectroscopy
- Author
-
Yinsheng Luo, Tianhu Wang, and Kexin Xu
- Subjects
Drug ,Chromatography ,Ultraviolet visible spectroscopy ,biology ,Chemistry ,Applied Mathematics ,media_common.quotation_subject ,biology.protein ,Bovine serum albumin ,media_common - Published
- 2017
43. Design and Implementation of a New Electronic Load for the Study of LED Driver.
- Author
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Tianhu Wang, Shanzhi Mou, Yue Hu, Yuntao Wu, and Tianyu Chen
- Subjects
- *
REAL-time control , *FUZZY logic , *PID controllers , *MATHEMATICAL models - Abstract
Electronic load can be used to test the characteristics of LED driver in the field conditions. In this work, a new electronic load for LED driver is designed, which could simulate the nonlinear volt-ampere characteristics of LED module. In order to study the real-time control performance of the system when setting the working current, a PID controller and a fuzzy-PID controller were designed based on the flexible online programming and control of LabVIEW software. At the same time, the mathematical model of the electronic load is calculated based on the theoretical volt-ampere characteristic curve of the LED module. The results show that the combination of fuzzy logic and PID control can make the design of the new electronic load get better control effect and meet the needs of practical application. [ABSTRACT FROM AUTHOR]
- Published
- 2020
44. Experimental Investigation of the Interaction Between Human Serum and Troxerutin by Fluorescence Spectroscopy
- Author
-
Jihua Zhang, Zhimin Zhao, and Tianhu Wang
- Subjects
General Chemistry - Published
- 2013
45. Spectroscopic investigations on the binding of dibazol to bovine serum albumin
- Author
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Lei Ji, Benzheng Wei, Lin Zhang, Tianhu Wang, and Zhimin Zhao
- Subjects
Quenching (fluorescence) ,biology ,Chemistry ,Organic Chemistry ,Enthalpy ,Analytical chemistry ,Fluorescence ,Analytical Chemistry ,Gibbs free energy ,Inorganic Chemistry ,Hydrophobic effect ,symbols.namesake ,biology.protein ,symbols ,Bovine serum albumin ,Spectroscopy ,Synchronous fluorescence - Abstract
The characteristics of the binding reaction of dibazol to bovine serum albumin (BSA) were investigated by fluorescence, UV–vis, resonance light scattering (RLS) and Fourier transform infrared (FT-IR) spectroscopy. Results show that dibazol causes the fluorescence quenching of BSA through a static quenching procedure. The binding constants for the formation of a complex between dibazol and BSA are 0.83, 1.23 and 1.62 × 105 mol−1 L at 295, 302 and 309 K, respectively. Positive values of thermodynamic parameters namely enthalpy change (ΔH) and entropy change (ΔS) indicate that the interaction between dibazol and BSA is driven mainly by hydrophobic forces. It seems that the binding is spontaneous at standard state for the change in standard Gibbs free energy (ΔG) value is negative. The binding distance between BSA and dibazol was calculated to be about 4.28 nm according to the Forster theory. The site marker competitive experiments confirmed that the binding of dibazol to BSA primarily occurred in site I of BSA. In addition, the effect of dibazol on the conformation of BSA was also analyzed by using synchronous fluorescence and FT-IR spectroscopy.
- Published
- 2010
46. Spectroscopic studies on the interaction between troxerutin and bovine serum albumin
- Author
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Tianhu Wang, Zhimin Zhao, Lin Zhang, and Lei Ji
- Subjects
Troxerutin ,Quenching (fluorescence) ,biology ,Chemistry ,Organic Chemistry ,Enthalpy ,Analytical chemistry ,Binding constant ,Fluorescence ,Analytical Chemistry ,Gibbs free energy ,Inorganic Chemistry ,Hydrophobic effect ,symbols.namesake ,biology.protein ,medicine ,symbols ,Physical chemistry ,Bovine serum albumin ,Spectroscopy ,medicine.drug - Abstract
The interaction between troxerutin and bovine serum albumin (BSA) was investigated by fluorescence and absorption spectroscopy under simulative physiological conditions. Results show that troxerutin causes the fluorescence quenching of BSA through a static quenching procedure. The binding constant K A and number of binding sites n of troxerutin with BSA were obtained. Positive values of thermodynamic parameters enthalpy change (Δ H ) and entropy change (Δ S ) indicate that the interaction between troxerutin and BSA is driven mainly by hydrophobic forces. It seems that the binding is spontaneous at standard state for the change in standard Gibbs free energy (Δ G ) value is negative. The binding distance between the donor (BSA) and the acceptor (troxerutin) was calculated to be about 4.21 nm based on the Forster theory. The effect of troxerutin on the conformation of BSA was also analyzed by using synchronous fluorescence spectroscopy.
- Published
- 2009
47. A three dimensional study of upper airway in adult skeletal Class II patients with different vertical growth patterns
- Author
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Mingye Zhang, Fang Yang, Zhenhua Yang, Jin-Long Zhao, Tianhu Wang, Jinwu Chen, and Yongming Li
- Subjects
Adult ,Male ,Pulmonology ,Clinical Research Design ,Respiratory System ,Oral Medicine ,lcsh:Medicine ,Malocclusion, Angle Class II ,Pathology and Laboratory Medicine ,Research and Analysis Methods ,Throat ,Correlation ,Young Adult ,symbols.namesake ,Imaging, Three-Dimensional ,Diagnostic Medicine ,Medicine and Health Sciences ,medicine ,Humans ,lcsh:Science ,Multidisciplinary ,business.industry ,Pharynx ,lcsh:R ,Biology and Life Sciences ,Sleep apnea ,Anatomy ,Cone-Beam Computed Tomography ,Skeletal class ,medicine.disease ,Pearson product-moment correlation coefficient ,medicine.anatomical_structure ,Neurology ,Otorhinolaryngology ,Anatomical Pathology ,Research Design ,symbols ,Female ,lcsh:Q ,Analysis of variance ,Malocclusion ,Sleep Disorders ,Airway ,business ,Neck ,Research Article - Abstract
Objective The study was performed to compare the 3D pharyngeal airway dimensions in adult skeletal Class II patients with different vertical growth patterns (low, normal, and high angle) and to investigate whether the upper airway dimensions of untreated skeletal Class II adults were affected by vertical skeletal variables. Methods Cone-beam computed tomography (CBCT) records of 64 untreated adult skeletal Class II patients (34 male and 30 female) were collected to evaluate the pharyngeal airway dimensions. Subjects were divided into three subgroups according to the GoGn-SN angle (low angle, normal angle or high angle). All subgroups were matched for sex. ANOVA and SNK - q tests were used to identify differences within and among groups (p
- Published
- 2014
48. Characterization of the interaction between reserpine and bovine serum albumin: spectroscopic approaches
- Author
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Tianhu, Wang, Zhimin, Zhao, Jin, Hua, and Jihua, Zhang
- Subjects
Reserpine ,Spectrometry, Fluorescence ,Spectroscopy, Fourier Transform Infrared ,Animals ,Cattle ,Serum Albumin, Bovine - Abstract
The characteristics of the interaction between reserpine and bovine serum albumin (BSA) were studied by fluorescence, UV-vis absorption and Fourier transform infrared (FT-IR) spectroscopy. Spectroscopic analysis revealed that fluorescence quenching of BSA by reserpine was through a static quenching procedure. The binding constant K(A) of reserpine with BSA at 293, 301 and 309 K was 1.63, 1.78 and 2.35 x 10(5) moL(-1) L respectively, which indicated degree of binding force between reserpine and BSA. There was one binding site between reserpine and BSA. The entropy and enthalpy changes were positive, indicating that interaction of reserpine and BSA was driven mainly by hydrophobic forces. The average binding distance between the donor (BSA) and the acceptor (reserpine) was about 3.84 nm based on the Forster non-radiation energy transfer theory. Results of synchronous fluorescence and FT-IR spectra indicated that the conformation and microenvironment of BSA were changed by the binding of reserpine. The results may provide important insights into the physiological activity of reserpine.
- Published
- 2012
49. Study on the Life Evaluation Method of LED Headlamp.
- Author
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Tianhu Wang, Yi Yan, and Kexin Xu
- Subjects
- *
LIGHT emitting diodes , *LIGHT sources , *OPTICAL display devices , *HEADLIGHT glare , *ELECTROLUMINESCENT devices - Abstract
Due to rapid progress in LED (Light Emitting Diode) technology, LEDs have become increasingly prevalent in applications to automotive lighting. This paper studied the life of LED headlamp by evaluating the illumination maintenance based on Arrhenius model. The experimental results that the illumination maintenance is 0.959 and 0.955 at 1000 hours accelerated aging at 35°C and 55°C respectively. This paper may provide a valuable reference for evaluating the life of LED headlamps. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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