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1. Is 70Zn(d,x)67Cu the Best Way to Produce 67Cu for Medical Applications?

Author

Etienne Nigron, Arnaud Guertin, Ferid Haddad, and Thomas Sounalet

Subjects
67Cu, production, theranostic, cross section, deuteron reactions, accelerators, Medicine (General), R5-920
Abstract

The pair of copper radionuclides 64Cu/67Cu (T1/2 = 12. 7 h/61.8 h) allows, respectively, PET imaging and targeted beta therapy. An analysis of the different production routes of 67Cu with charged particles was performed and the reaction 70Zn(d,x) route was identified as a promising one. It may allow the production of 67Cu without 64Cu. The production cross section has been measured up to 28.7 MeV. Measurements were done using the well-known stacked-foils technique using 97.5% enriched 70Zn homemade electroplated targets. These measurements complement at higher incident energies the only set of data available in nuclear databases. The results show that using a 26 MeV deuteron beam and a highly enriched 70Zn target, it is possible to produce high purity 67Cu comparable to that obtained using photoproduction. This production route can be of interest for future linear accelerators under development where mA deuteron beams can be available if adequate targetry is developed.

Published
2021
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2. Cyclotron production of 67Cu: A new measurement of the 68Zn(p,2p)67Cu, 68Zn(p,2n)67Ga and 68Zn(p,3n)66Ga nuclear cross sections

Author

Gaia Pupillo, Thomas Sounalet, Nathalie Michel, Férid Haddad, Liliana Mou, Luciano Canton, Andrea Fontana, Juan Esposito, and Adriano Duatti

Subjects
producción de isotopos, generadores de radisótopos, ciclotrones, secciones eficaces, cobre 6, Nuclear engineering. Atomic power, TK9001-9401, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

The cross sections of the 68Zn(p,2p)67Cu,68Zn(p,2n)67Ga and 68Zn(p,3n)66Ga reactions were measured at the ARRONAX facility by using the 70 MeV cyclotron, with particular attention to the production of the theranostic radionuclide 67Cu. Enriched 68Zn material was electroplated on silver backing and exposed to alow-intensity proton beam by using the stacked-foils target method. Since 67Cu and 67Ga radionuclides have similar half-lives and same γ-lines (they both decay to 67Zn), a radiochemical process aimed at Cu/Ga separation was mandatory to avoid interferences in γ-spectrometry measurements. A simple chemical procedure having a high separation efficiency (>99%)was developed and monitored during each foil processing, thanks to the tracer isotopes 61Cu and 66Ga.Nuclear cross sections were measured in the energy range 35-70 MeV by using reference reactions recommended by the International Atomic Energy Agency (IAEA) to monitor beam flux. In comparison with literature data a general good agreement on the trend of the nuclear reactions was noted, especially with latest measurements, but slightly lower values were obtained in case of 67Cu. Experimental results of the 68Zn(p,2p)67Cu,68Zn(p,2n)67Ga and 68Zn(p,3n)66Ga reactions were also compared with the theoretical values estimated by using the nuclear reaction code TALYS. The production yield of the theranostic radionuclide 67Cu was estimated considering the results obtained in this work.

Published
2019

3. Electrochemical co-deposition of Ni-Gd

Author

Yizheng, Wang, Thomas, Sounalet, Arnaud, Guertin, Férid, Haddad, Nathalie, Michel, and Etienne, Nigron

Subjects
Cyclotrons
Abstract

In the last years

Published
2022

4. Exploring radiation hardness of PEPITES, a new transparent charged particle beam profiler

Author

Eric Delagnes, Y. Geerebaert, Nathalie Michel, F. Gebreyohannes, S. Elidrissi-Moubtassim, O. Thiam, F. Haddad, N. Audouin, Noël Servagent, Thomas Sounalet, B. Boyer, Charbel Koumeir, F. Poirier, O. Gevin, P. Manigot, M. Verderi, C. Thiebaux, Frédéric Magniette, G. Blain, Cyclotron ARRONAX, GIP, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), ANR-16-IDEX-0007,NExT (I-SITE),NExT (I-SITE)(2016), and ANR-17-CE31-0015,PEPITES,Développement d'un moniteur ultra-mince pour faisceau de particules chargées(2017)

Subjects
[PHYS]Physics [physics], Nuclear and High Energy Physics, Materials science, Protontherapy, 010308 nuclear & particles physics, business.industry, Scanning electron microscope, Beam profiler, 01 natural sciences, Fluence, 030218 nuclear medicine & medical imaging, Kapton, 03 medical and health sciences, 0302 clinical medicine, Damage, 0103 physical sciences, Optoelectronics, Irradiation, Charged particle beam, business, Instrumentation, Radiation hardening, Polyimide, Beam (structure)
Abstract

International audience; PEPITES is a new type of transparent beam profiler (

Published
2020

5. THE RADIOBIOLOGICAL PLATFORM AT ARRONAX

Author

Sébastien Gouard, Nathalie Michel, Nicolas Varmenot, Arnaud Guertin, Noël Servagent, Michel Chérel, Eric Garrido, Vincent Métivier, Viviana De Nadal, Roberto Cherubini, Thomas Sounalet, Freddy Poirier, Ferid Haddad, Charbel Koumeir, GIPARRONAX [Saint-Herblain, France], Laboratori Nazionali di Legnaro (LNL), Istituto Nazionale di Fisica Nucleare (INFN), Nuclear Oncology (CRCINA-ÉQUIPE 13), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, This project is partially supported by the ‘Agence National de la Recherche’, called ‘Investissements d’Avenir’, Equipex ArronaxPlus n° ANR-11-EQPX-0004., ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), Bernardo, Elizabeth, Nucléaire pour la Santé - - ARRONAXPLUS2011 - ANR-11-EQPX-0004 - EQPX - VALID, Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique)

Subjects
[PHYS.NEXP] Physics [physics]/Nuclear Experiment [nucl-ex], Cyclotron, [SDV.CAN]Life Sciences [q-bio]/Cancer, Radiation, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 030218 nuclear medicine & medical imaging, law.invention, Nuclear physics, 03 medical and health sciences, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, law, Humans, Radiology, Nuclear Medicine and imaging, Irradiation, Physics, Range (particle radiation), [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Radiological and Ultrasound Technology, Public Health, Environmental and Occupational Health, Radiobiology, General Medicine, Alpha particle, Equipment Design, V79 cells, Cyclotrons, Charged particle, Beamline, 030220 oncology & carcinogenesis, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], France
Abstract

International audience; The cyclotron ARRONAX can deliver different types of particles (protons, deuterons, alpha-particles) in an energy range up to 68 MeV. One of its six experimental halls is dedicated to studying the interactions of radiation with matter including living matter. A horizontal beamline for cell irradiation has been setup and characterized. The radiobiological characterization was done in terms of V79 cells survival after irradiation with 68 MeV protons. The results demonstrate that radiobiological studies can be successfully performed confirming the high potential of the facility.

Published
2018

6. New production cross sections for the theranostic radionuclide 67 Cu

Author

Liliana Mou, Nathalie Michel, Thomas Sounalet, Gaia Pupillo, Juan Esposito, Ferid Haddad, Laboratori Nazionali di Legnaro (LNL), Istituto Nazionale di Fisica Nucleare (INFN), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Accélérateur pour la Recherche en Radiochimie et Oncologie [Nantes Atlantique] (GIP ARRONAX), Université de Nantes (UN)-Hôpital Guillaume-et-René-Laennec [Saint-Herblain]-Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER-UNICANCER, Università degli Studi di Ferrara (UniFE), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), and ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public)

Subjects
Nuclear reaction, [PHYS]Physics [physics], Nuclear and High Energy Physics, Radionuclide, Proton, Isotope, Chemistry, Radiochemistry, Cyclotron, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 010403 inorganic & nuclear chemistry, 7. Clean energy, 01 natural sciences, 030218 nuclear medicine & medical imaging, 0104 chemical sciences, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, TRACER, Yield (chemistry), Instrumentation, Beam (structure), ComputingMilieux_MISCELLANEOUS
Abstract

The cross sections of the 68Zn(p,2p)67Cu, 68Zn(p,2n)67Ga and 68Zn(p,3n)66Ga reactions were measured at the ARRONAX facility by using the 70 MeV cyclotron, with particular attention to the production of the theranostic radionuclide 67Cu. Enriched 68Zn material was electroplated on silver backing and exposed to a low-intensity proton beam by using the stacked-foils target method. Since 67Cu and 67Ga radionuclides have similar half-lives and same γ-lines (they both decay to 67Zn), a radiochemical process aimed at Cu/Ga separation was mandatory to avoid interferences in γ-spectrometry measurements. A simple chemical procedure having a high separation efficiency (>99%) was developed and monitored during each foil processing, thanks to the tracer isotopes 61Cu and 66Ga. Nuclear cross sections were measured in the energy range 35–70 MeV by using reference reactions recommended by the International Atomic Energy Agency (IAEA) to monitor beam flux. In comparison with literature data a general good agreement on the trend of the nuclear reactions was noted, especially with latest measurements, but slightly lower values were obtained in case of 67Cu. Experimental results of the 68Zn(p,2p)67Cu, 68Zn(p,2n)67Ga and 68Zn(p,3n)66Ga reactions were also compared with the theoretical values estimated by using the software TALYS. The production yield of the theranostic radionuclide 67Cu was estimated considering the results obtained in this work.

Published
2018

7. Strontium-82 and Future Germanium-68 Production at the ARRONAX Facility

Author

M. Guillamet, T. Milleto, S. Fresneau, G. Bouvet, J. M. Buhour, A. Cadiou, Jacques Barbet, J. Laizé, V. Bossé, A.C. Bonraisin, A. Audouin, Y. Bortoli, M. Mokili, Ferid Haddad, C. Bourdeau, Gilles Montavon, Thomas Sounalet, Cyrille Alliot, Nathalie Michel, F. Milon, Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), GIP ARRONAX, Université de Nantes (UN), Département de recherche en cancérologie, Université de Nantes (UN)-IFR26, Cyclotron ARRONAX, Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
Nuclear and High Energy Physics, Materials science, Cyclotron, chemistry.chemical_element, Germanium, Rubidium chloride, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 010403 inorganic & nuclear chemistry, 01 natural sciences, 7. Clean energy, 030218 nuclear medicine & medical imaging, Rubidium, law.invention, Nuclear physics, 03 medical and health sciences, chemistry.chemical_compound, [SPI]Engineering Sciences [physics], 0302 clinical medicine, law, [CHIM]Chemical Sciences, Irradiation, Gallium, ComputingMilieux_MISCELLANEOUS, [PHYS]Physics [physics], Radionuclide, Nuclear data, [CHIM.MATE]Chemical Sciences/Material chemistry, 0104 chemical sciences, 3. Good health, chemistry
Abstract

International audience; The ARRONAX cyclotron is fully operational since the end of 2010. It delivers projectiles (p, d, alpha) at high energy (up to 70 MeV for protons) and high intensity(2*375 mu A for protons). The main fields of application of ARRONAX are radionuclide production for nuclear medicine and irradiation of inert or living materials for radiolysis and radio-biology studies. A large part of the beam time will be used to produce radionuclides for targeted radionuclide therapy (copper-67, scandium-47 and astatine-211) as well as for PET imaging (scandium-44, copper-64, strontium-82 for rubidium-82 generators, and germanium-68 for gallium-68 generators). Since June 2012, large scale production of Sr-82 has started with rubidium chloride (RbCl) targets. Several improvements are being explored which consist of changing the target material from RbCl to Rb metal and introducing an additional target behind the rubidium assembly. Thus, a target alloy of nickel/gallium for germanium-68 production has been developed. It is obtained by electroplating and exhibits a better thermal behavior than the natural gallium target used in most production facilities.

Published
2014

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