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2. Characteristics and Outcomes of Individuals With Pre-existing Kidney Disease and COVID-19 Admitted to Intensive Care Units in the United States

Author

Flythe, Jennifer E, Assimon, Magdalene M, Tugman, Matthew J, Chang, Emily H, Gupta, Shruti, Shah, Jatan, Sosa, Marie Anne, Renaghan, Amanda DeMauro, Melamed, Michal L, Wilson, F Perry, Neyra, Javier A, Rashidi, Arash, Boyle, Suzanne M, Anand, Shuchi, Christov, Marta, Thomas, Leslie F, Edmonston, Daniel, Leaf, David E, Walther, Carl P, Anumudu, Samaya J, Arunthamakun, Justin, Kopecky, Kathleen F, Milligan, Gregory P, McCullough, Peter A, Nguyen, Thuy-Duyen, Shaefi, Shahzad, Krajewski, Megan L, Shankar, Sidharth, Pannu, Ameeka, Valencia, Juan D, Waikar, Sushrut S, Kibbelaar, Zoe A, Athavale, Ambarish M, Hart, Peter, Upadhyay, Shristi, Vohra, Ishaan, Green, Adam, Rachoin, Jean-Sebastien, Schorr, Christa A, Shea, Lisa, Edmonston, Daniel L, Mosher, Christopher L, Shehata, Alexandre M, Cohen, Zaza, Allusson, Valerie, Bambrick-Santoyo, Gabriela, Bhatti, Noor ul aain, Mehta, Bijal, Williams, Aquino, Brenner, Samantha K, Walters, Patricia, Go, Ronaldo C, Rose, Keith M, Chan, Lili, Mathews, Kusum S, Coca, Steven G, Altman, Deena R, Saha, Aparna, Soh, Howard, Wen, Huei Hsun, Bose, Sonali, Leven, Emily A, Wang, Jing G, Mosoyan, Gohar, Nadkarni, Girish N, Pattharanitima, Pattharawin, Gallagher, Emily J, Friedman, Allon N, Guirguis, John, Kapoor, Rajat, Meshberger, Christopher, Kelly, Katherine J, Parikh, Chirag R, Garibaldi, Brian T, Corona-Villalobos, Celia P, Wen, Yumeng, Menez, Steven, Malik, Rubab F, Cervantes, Carmen Elena, Gautam, Samir C, Mallappallil, Mary C, Ouyang, Jie, John, Sabu, Yap, Ernie, Melaku, Yohannes, Mohamed, Ibrahim, Bajracharya, Siddhartha, Puri, Isha, Thaxton, Mariah, Bhattacharya, Jyotsna, Wagner, John, Boudourakis, Leon, Nguyen, H Bryant, Ahoubim, Afshin, Kashani, Kianoush, Tehranian, Shahrzad, Sirganagari, Dheeraj Reddy, Guru, Pramod K, and Zhou, Yan

Subjects
Clinical Research, Cardiovascular, Clinical Trials and Supportive Activities, Kidney Disease, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Renal and urogenital, Good Health and Well Being, Aged, COVID-19, Comorbidity, Critical Illness, Female, Hospital Mortality, Humans, Intensive Care Units, Kidney Function Tests, Male, Renal Dialysis, Renal Insufficiency, Chronic, Retrospective Studies, Risk Factors, SARS-CoV-2, Treatment Outcome, United States, STOP-COVID Investigators, COVID-19 outcome, Coronavirus disease 2019, altered mental status, chronic kidney disease, clinical course, clinical trajectory, critical illness, dialysis, end-stage kidney disease, end-stage renal disease, glomerular filtration rate, in-hospital mortality, intensive care unit, prognosis, renal function, severe COVID-19, severe acute respiratory syndrome coronavirus 2, Clinical Sciences, Public Health and Health Services, Urology & Nephrology
Abstract

Rationale & objectiveUnderlying kidney disease is an emerging risk factor for more severe coronavirus disease 2019 (COVID-19) illness. We examined the clinical courses of critically ill COVID-19 patients with and without pre-existing chronic kidney disease (CKD) and investigated the association between the degree of underlying kidney disease and in-hospital outcomes.Study designRetrospective cohort study.Settings & participants4,264 critically ill patients with COVID-19 (143 patients with pre-existing kidney failure receiving maintenance dialysis; 521 patients with pre-existing non-dialysis-dependent CKD; and 3,600 patients without pre-existing CKD) admitted to intensive care units (ICUs) at 68 hospitals across the United States.Predictor(s)Presence (vs absence) of pre-existing kidney disease.Outcome(s)In-hospital mortality (primary); respiratory failure, shock, ventricular arrhythmia/cardiac arrest, thromboembolic events, major bleeds, and acute liver injury (secondary).Analytical approachWe used standardized differences to compare patient characteristics (values>0.10 indicate a meaningful difference between groups) and multivariable-adjusted Fine and Gray survival models to examine outcome associations.ResultsDialysis patients had a shorter time from symptom onset to ICU admission compared to other groups (median of 4 [IQR, 2-9] days for maintenance dialysis patients; 7 [IQR, 3-10] days for non-dialysis-dependent CKD patients; and 7 [IQR, 4-10] days for patients without pre-existing CKD). More dialysis patients (25%) reported altered mental status than those with non-dialysis-dependent CKD (20%; standardized difference=0.12) and those without pre-existing CKD (12%; standardized difference=0.36). Half of dialysis and non-dialysis-dependent CKD patients died within 28 days of ICU admission versus 35% of patients without pre-existing CKD. Compared to patients without pre-existing CKD, dialysis patients had higher risk for 28-day in-hospital death (adjusted HR, 1.41 [95% CI, 1.09-1.81]), while patients with non-dialysis-dependent CKD had an intermediate risk (adjusted HR, 1.25 [95% CI, 1.08-1.44]).LimitationsPotential residual confounding.ConclusionsFindings highlight the high mortality of individuals with underlying kidney disease and severe COVID-19, underscoring the importance of identifying safe and effective COVID-19 therapies in this vulnerable population.

Published
2021

3. Kidney Recovery and Death in Critically Ill Patients With COVID-19–Associated Acute Kidney Injury Treated With Dialysis: The STOP-COVID Cohort Study

Author

Gupta, Hsu, Faugno, Goyal, Raichoudhury, Tariq, Meyer, Sharma, Leaf, Kshirsagar, Walther, Carl P., Anumudu, Samaya J., Arunthamakun, Justin, Kopecky, Kathleen F., Milligan, Gregory P., McCullough, Peter A., Nguyen, Thuy-Duyen, Shaefi, Shahzad, Krajewski, Megan L., Shankar, Sidharth, Pannu, Ameeka, Valencia, Juan D., Bauer, Kenneth A., Waikar, Sushrut S., Kibbelaar, Zoe A., Athavale, Ambarish M., Hart, Peter, Upadhyay, Shristi, Vohra, Ishaan, Oyintayo, Ajiboye, Green, Adam, Rachoin, Jean-Sebastien, Schorr, Christa A., Shea, Lisa, Edmonston, Daniel L., Mosher, Christopher L., Shehata, Alexandre M., Cohen, Zaza, Allusson, Valerie, Bambrick-Santoyo, Gabriela, Bhatti, Noor ul aain, Mehta, Bijal, WilliamsSamantha K. Brenner, Aquino, Walters, Patricia, Go, Ronaldo C., Rose, Keith M., Hernán, Miguel A., Zhou, Amy M., Kim, Ethan C., Lisk, Rebecca, Chan, Lili, Mathews, Kusum S., Coca, Steven G., Altman, Deena R., Saha, Aparna, Soh, Howard, Wen, Huei Hsun, Bose, Sonali, Leven, Emily A., Wang, Jing G., Mosoyan, Gohar, Pattharanitima, Pattharawin, Gallagher, Emily J., Friedman, Allon N., Guirguis, John, Kapoor, Rajat, Meshberger, Christopher, Kelly, Katherine J., Parikh, Chirag R., Garibaldi, Brian T., Corona-Villalobos, Celia P., Wen, Yumeng, Menez, Steven, Malik, Rubab F., Cervantes, Carmen Elena, Gautam, Samir C., Mallappallil, Mary C., Ouyang, Jie, John, Sabu, Yap, Ernie, Melaku, Yohannes, Mohamed, Ibrahim, Bajracharya, Siddhartha, Puri, Isha, Thaxton, Mariah, Bhattacharya, Jyotsna, Wagner, John, Boudourakis, Leon, Nguyen, H. Bryant, Ahoubim, Afshin, Thomas, Leslie F., Sirganagari, Dheeraj Reddy, Guru, Pramod K., Kashani, Kianoush, Tehranian, Shahrzad, Zhou, Yan, Bergl, Paul A., Rodriguez, Jesus, Shah, Jatan A., Gupta, Mrigank S., Kumar, Princy N., Lazarous, Deepa G., Kassaye, Seble G., Melamed, Michal L., Johns. Ryan Mocerino, Tanya S., Prudhvi, Kalyan, Zhu, Denzel, Levy, Rebecca V., Azzi, Yorg, Fisher, Molly, Yunes, Milagros, Sedaliu, Kaltrina, Golestaneh, Ladan, Brogan, Maureen, Thakkar, Jyotsana, Kumar, Neelja, Ross, Michael J., Chang, Michael, Athreya, Akshay, Farag, Mohamed, Schenck, Edward J., Cho, Soo Jung, Plataki, Maria, Alvarez-Mulett, Sergio L., Gomez-Escobar, Luis G., Pan, Di, Lee, Stefi, Krishnan, Jamuna, Whalen, William, Charytan, David, Macina, Ashley, Srivastava, Anand, Leidner, Alexander S., Martinez, Carlos, Kruser, Jacqueline M., Wunderink, Richard G., Hodakowski, Alexander J., Velez, Juan Carlos Q., Price-Haywood, Eboni G., Matute-Trochez, Luis A., Hasty, Anna E., Mohamed, Muner M.B., Avasare, Rupali S., Zonies, David, Al-Samkari, Hanny, Leaf, Rebecca Karp, Rosovsky, Rachel, Sise, Meghan E., Newman, Erik T., Omar, Samah Abu, Pokharel, Kapil K., Sharma, Shreyak, Singh, Harkarandeep, Correa, Simon, Shaukat, Tanveer, Kamal, Omer, Wang, Wei, Lee, Meghan, Strohbehn, Ian A., Li, Jiahua, Mueller, Ariel L., Redfern, Roberta E., Cairl, Nicholas S., Naimy, Gabriel, Abu-Saif, Abeer, Hall, Danyell, Bickley, Laura, Rowan, Chris, Madhani-Lovely, Farah, Peev, Vasil, Reiser, Jochen, Byun, John J., Vissing, Andrew, Kapania, Esha M., Post, Zoe, Patel, Nilam P., Hermes, Joy-Marie, Sutherland, Anne K., Patrawalla, Amee, Finkel, Diana G., Danek, Barbara A., Arikapudi, Sowminya, Paer, Jeffrey M., Cangialosi, Peter, Liotta, Mark, Radbel, Jared, Puri, Sonika, Sunderram, Jag, Scharf, Matthew T., Ahmed, Ayesha, Berim, Ilya, Vatson, Jayanth S., Karp, George, Anand, Shuchi, Levitt, Joseph E., Garcia, Pablo, Boyle, Suzanne M., Song, Rui, Zhang, Jingjing, Woo, Sang Hoon, Deng, Xiaoying, Katz-Greenberg, Goni, Sharshir, Moh’d A., Rusnak, Vadym V., Bansal, Anip, Podoll, Amber S., Chonchol, Michel, Sharma, Sunita, Burnham, Ellen L., Rashidi, Arash, Hejal, Rana, Judd, Eric, Latta, Laura, Tolwani, Ashita, Albertson, Timothy E., Adams, Jason Y., Chang, Steven Y., Beutler, Rebecca M., Schulze, Carl E., Macedo, Etienne, RheeKa, Harin, thleen D. Liu, Jotwani, Vasantha K., Koyner, Jay L., Shah, Chintan V., Jaikaransingh, Vishal, Toth-Manikowski, Stephanie M., Joo, Min J., Lash, James P., Neyra, Javier A., Chaaban, Nourhan, Elias, Madona, Ahmad, Yahya, Dy, Rajany, Iardino, Alfredo, Au, Elizabeth H., Sosa, Marie Anne, Taldone, Sabrina, Contreras, Gabriel, De La Zerda, David, Gershengorn, Hayley B., Fornoni, Alessia, Hayek, Salim S., Blakely, Pennelope, Berlin, Hanna, Azam, Tariq U., Shadid, Husam, Pan, Michael, O’Hayer, Patrick, Meloche, Chelsea, Feroze, Rafey, Padalia, Kishan J., Leya, Jeff, Donnelly, John P., Admon, Andrew J., Flythe, Jennifer E., Tugman, Matthew J., Chang, Emily H., Brown, Brent R., Leonberg-Yoo, Amanda K., Spiardi, Ryan C., Miano, Todd A., Roche, Meaghan S., Vasquez, Charles R., Bansal, Amar D., Ernecoff, Natalie C., Kapoor, Sanjana, Verma, Siddharth, Chen, Huiwen, Kovesdy, Csaba P., Molnar, Miklos Z., Azhar, Ambreen, Hedayati, S. Susan, Nadamuni, Mridula V., Shastri, Shani, Willett, Duwayne L., Short, Samuel A.P., Renaghan, Amanda D., Enfield, Kyle B., Bhatraju, Pavan K., Malik, A. Bilal, Semler, Matthew W., Vijayan, Anitha, Joy, Christina Mariyam, Li, Tingting, Goldberg, Seth, Kao, Patricia F., Schumaker, Greg L., Christov, Marta, Griffiths, Jennifer, Gupta, Sanjeev, Kapoor, Aromma, Chugh, Savneek, Wilson, Perry, Arora, Tanima, Ugwuowo, Ugochukwu, Hsu, Caroline M., Gupta, Shruti, Tighiouart, Hocine, Goyal, Nitender, Faugno, Anthony J., Tariq, Asma, Raichoudhury, Ritesh, Sharma, Jill H., Meyer, Leah, Kshirsagar, Ravi K., Jose, Aju, Leaf, David E., and Weiner, Daniel E.

Published
2022
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5. Modulation of the Association Between Age and Death by Risk Factor Burden in Critically Ill Patients With COVID-19

Author

Sunderraj, Ashwin, Cho, Chloe, Cai, Xuan, Gupta, Shruti, Mehta, Rupal, Isakova, Tamara, Leaf, David E., Srivastava, Anand, Walther, Carl P., Anumudu, Samaya J., Arunthamakun, Justin, Kopecky, Kathleen F., Milligan, Gregory P., McCullough, Peter A., Nguyen, Thuy-Duyen, Shaefi, Shahzad, Krajewski, Megan L., Shankar, Sidharth, Pannu, Ameeka, Valencia, Juan D., Waikar, Sushrut S., Kibbelaar, Zoe A., Athavale, Ambarish M., Hart, Peter, Upadhyay, Shristi, Vohra, Ishaan, Oyintayo, Ajiboye, Green, Adam, Rachoin, Jean-Sebastien, Schorr, Christa A., Shea, Lisa, Edmonston, Daniel L., Mosher, Christopher L., Shehata, Alexandre M., Cohen, Zaza, Allusson, Valerie, Bambrick-Santoyo, Gabriela, Bhatti, Noor ul aain, Mehta, Bijal, Williams, Aquino, Brenner, Samantha K., Walters, Patricia, Go, Ronaldo C., Rose, Keith M., Hernán, Miguel A., Zhou, Amy M., Kim, Ethan C., Lisk, Rebecca, Chan, Lili, Mathews, Kusum S., Coca, Steven G., Altman, Deena R., Saha, Aparna, Soh, Howard, Hsun Wen, Huei, Bose, Sonali, Leven, Emily A., Wang, Jing G., Mosoyan, Gohar, Nadkarni, Girish N., Pattharanitima, Pattharawin, Gallagher, Emily J., Friedman, Allon N., Guirguis, John, Kapoor, Rajat, Meshberger, Christopher, Kelly, Katherine J., Parikh, Chirag R., Garibaldi, Brian T., Corona-Villalobos, Celia P., Wen, Yumeng, Menez, Steven, Malik, Rubab F., Elena Cervantes, Carmen, Gautam, Samir C., Mallappallil, Mary C., Ouyang, Jie, John, Sabu, Yap, Ernie, Melaku, Yohannes, Mohamed, Ibrahim, Bajracharya, Siddhartha, Puri, Isha, Thaxton, Mariah, Bhattacharya, Jyotsna, Wagner, John, Boudourakis, Leon, Bryant Nguyen, H., Ahoubim, Afshin, Thomas, Leslie F., Sirganagari, Dheeraj Reddy, Guru, Pramod K., Kashani, Kianoush, Tehranian, Shahrzad, Zhou, Yan, Bergl, Paul A., Rodriguez, Jesus, Shah, Jatan A., Gupta, Mrigank S., Kumar, Princy N., Lazarous, Deepa G., Kassaye, Seble G., Melamed, Michal L., Johns, Tanya S., Mocerino, Ryan, Prudhvi, Kalyan, Zhu, Denzel, Levy, Rebecca V., Azzi, Yorg, Fisher, Molly, Yunes, Milagros, Sedaliu, Kaltrina, Golestaneh, Ladan, Brogan, Maureen, Kumar, Neelja, Chang, Michael, Thakkar, Jyotsana, Raichoudhury, Ritesh, Athreya, Akshay, Farag, Mohamed, Schenck, Edward J., Cho, Soo Jung, Plataki, Maria, Alvarez-Mulett, Sergio L., Gomez-Escobar, Luis G., Pan, Di, Lee, Stefi, Krishnan, Jamuna, Whalen, William, Charytan, David, Macina, Ashley, Chaudhry, Sobaata, Wu, Benjamin, Modersitzki, Frank, Srivastava, Anand, Leidner, Alexander S., Martinez, Carlos, Kruser, Jacqueline M., Wunderink, Richard G., Hodakowski, Alexander J., Velez, Juan Carlos Q., Price-Haywood, Eboni G., Matute-Trochez, Luis A., Hasty, Anna E., Mohamed, Muner MB., Avasare, Rupali S., Zonies, David, Leaf, David E., Gupta, Shruti, Sise, Meghan E., Newman, Erik T., Abu Omar, Samah, Pokharel, Kapil K., Sharma, Shreyak, Singh, Harkarandeep, Correa, Simon, Shaukat, Tanveer, Kamal, Omer, Wang, Wei, Yang, Heather, Boateng, Jeffery O., Lee, Meghan, Strohbehn, Ian A., Li, Jiahua, Mueller, Ariel L., Redfern, Roberta E., Cairl, Nicholas S., Naimy, Gabriel, Abu-Saif, Abeer, Hall, Danyell, Bickley, Laura, Rowan, Chris, Madhani-Lovely, Farah, Cruz, Vivian S., Hess, Kristen M., Jacobs, Alanna L., Peev, Vasil, Reiser, Jochen, Byun, John J., Vissing, Andrew, Kapania, Esha M., Post, Zoe, Patel, Nilam P., Hermes, Joy-Marie, Sutherland, Anne K., Patrawalla, Amee, Finkel, Diana G., Danek, Barbara A., Arikapudi, Sowminya, Paer, Jeffrey M., Cangialosi, Peter, Liotta, Mark, Radbel, Jared, Puri, Sonika, Sunderram, Jag, Scharf, Matthew T., Ahmed, Ayesha, Berim, Ilya, Vatson, Jayanth S., Anand, Shuchi, Levitt, Joseph E., Garcia, Pablo, Boyle, Suzanne M., Song, Rui, Zhang, Jingjing, Hoon Woo, Sang, Deng, Xiaoying, Katz-Greenberg, Goni, Senter, Katharine, Sharshir, Moh’d A., Rusnak, Vadym V., Ali, Muhammad Imran, Bansal, Anip, Podoll, Amber S., Chonchol, Michel, Sharma, Sunita, Burnham, Ellen L., Douin, David J., Rashidi, Arash, Hejal, Rana, Judd, Eric, Latta, Laura, Tolwani, Ashita, Albertson, Timothy E., Adams, Jason Y., Chang, Steven Y., Beutler, Rebecca M., Schulze, Carl E., Macedo, Etienne, Rhee, Harin, Liu, Kathleen D., Jotwani, Vasantha K., Koyner, Jay L., Shah, Chintan V., Jaikaransingh, Vishal, Toth-Manikowski, Stephanie M., Joo, Min J., Lash, James P., Neyra, Javier A., Chaaban, Nourhan, Elias, Madona, Ahmad, Yahya, Iardino, Alfredo, Au, Elizabeth H., Sharma, Jill H., Anne Sosa, Marie, Taldone, Sabrina, Contreras, Gabriel, De La Zerda, David, Gershengorn, Hayley B., Shukla, Bhavarth, Fornoni, Alessia, Ferreira, Tanira, Hayek, Salim S., Blakely, Pennelope, Berlin, Hanna, Azam, Tariq U., Shadid, Husam, Pan, Michael, O’ Hayer, Patrick, Meloche, Chelsea, Feroze, Rafey, Kaakati, Rayan, Perry, Danny, Bitar, Abbas, Anderson, Elizabeth, Padalia, Kishan J., Donnelly, John P., Admon, Andrew J., Flythe, Jennifer E., Tugman, Matthew J., Chang, Emily H., Brown, Brent R., Leonberg-Yoo, Amanda K., Spiardi, Ryan C., Miano, Todd A., Roche, Meaghan S., Vasquez, Charles R., Bansal, Amar D., Ernecoff, Natalie C., Kapoor, Sanjana, Verma, Siddharth, Chen, Huiwen, Kovesdy, Csaba P., Molnar, Miklos Z., Azhar, Ambreen, Susan Hedayati, S., Nadamuni, Mridula V., Shastri, Shani, Willett, Duwayne L., Short, Samuel A.P., Renaghan, Amanda D., Enfield, Kyle B., Bhatraju, Pavan K., Bilal Malik, A., Semler, Matthew W., Vijayan, Anitha, Mariyam Joy, Christina, Li, Tingting, Goldberg, Seth, Kao, Patricia F., Schumaker, Greg L., Goyal, Nitender, Faugno, Anthony J., Schumaker, Greg L., Hsu, Caroline M., Tariq, Asma, Meyer, Leah, Kshirsagar, Ravi K., Weiner, Daniel E., Jose, Aju, Christov, Marta, Griffiths, Jennifer, Gupta, Sanjeev, Kapoor, Aromma, Wilson, Perry, Arora, Tanima, and Ugwuowo, Ugochukwu

Published
2022
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6. Machine Learning Prediction of Death in Critically Ill Patients With Coronavirus Disease 2019

Author

Churpek, Matthew M., Gupta, Shruti, Spicer, Alexandra B., Hayek, Salim S., Srivastava, Anand, Chan, Lili, Melamed, Michal L., Brenner, Samantha K., Radbel, Jared, Madhani-Lovely, Farah, Bhatraju, Pavan K., Bansal, Anip, Green, Adam, Goyal, Nitender, Shaefi, Shahzad, Parikh, Chirag R., Semler, Matthew W., Leaf, David E., Walther, Carol P., Anumudu, Samaya J., Arunthamakun, Justin, Kopecky, Kathleen F., Milligan, Gregory P., McCullough, Peter A., Nguyen, ThuyDuyen, Shaefi, Shahzad, Krajewski, Megan L., Shankar, Sidharth, Pannu, Ameeka, Valencia, Juan D., Waikar, Sushrut S., Kibbelaar, Zoe A., Athavale, Ambarish M., Hart, Peter, Ajiboye, Oyintayo, Itteera, Matthew, Green, Adam, Rachoin, Jean-Sebastien, Schorr, Christa A., Shea, Lisa, Edmonston, Daniel L., Mosher, Christopher L., Shehata, Alexandre M., Cohen, Zaza, Allusson, Valerie, Bambrick-Santoyo, Gabriela, Bhatti, Noor ul aain, Metha, Bijal, Williams, Aquino, Brenner, Samantha K., Walters, Patricia, Go, Ronaldo C., Rose, Keith M., Hernán, Miguel A., Zhou, Amy M., Kim, Ethan C., Lisk, Rebecca, Chan, Lili, Mathews, Kusum S., Coca, Steven G., Altman, Deena R., Saha, Aparna, Soh, Howard, Wen, Huei Hsun, Bose, Sonali, Leven, Emily, Wang, Jing G., Mosoyan, Gohar, Nadkarni, Girish N., Friedman, Allon N., Guirguis, John, Kapoor, Rajat, Meshberger, Christopher, Parikh, Chirag R., Garibaldi, Brian T., Corona-Villalobos, Celia P., Wen, Yumeng, Menez, Steven, Malik, Rubab F., Cervantes, Carmen Elena, Gautam, Samir C., Chang, Crystal, Nguyen, H. Bryant, Ahoubim, Afshin, Thomas, Leslie F., Guru, Pramod K., Bergl, Paul A., Zhou, Yan, Rodriguez, Jesus, Shah, Jatan A., Gupta, Mrigank S., Kumar, Princy N., Lazarous, Deepa G., Kassaye, Seble G., Melamed, Michal L., Johns, Tanya S., Mocerino, Ryan, Prudhvi, Kalyan, Zhu, Denzel, Levy, Rebecca V., Azzi, Yorg, Fisher, Molly, Yunes, Milagros, Sedaliu, Kaltrina, Golestaneh, Ladan, Brogan, Maureen, Thakkar, Jyotsana, Kumar, Neelja, Ross, Michael J., Chang, Michael, Raichoudhury, Ritesh, Schenck, Edward J., Cho, Soo Jung, Plataki, Maria, Alvarez-Mulett, Sergio L., Gomez-Escobar, Luis G., Pan, Di, Lee, Stefi, Krishnan, Jamuna, Whalen, William, Charytan, David, Macina, Ashley, Ross, Daniel W., Srivastava, Anand, Leidner, Alexander S., Martinez, Carlos, Kruser, Jacqueline M., Wunderink, Richard G., Hodakowski, Alexander J., Velez, Juan Carlos Q., Price-Haywood, Eboni G., Matute-Trochez, Luis A., Hasty, Anna E., Mohamed, Muner MB., Avasare, Rupali S., Zonies, David, Leaf, David E., Gupta, Shruti, Baron, Rebecca M., Sise, Meghan E., Newman, Erik T., Omar, Samah Abu, Pokharel, Kapil K., Sharma, Shreyak, Singh, Harkarandeep, Gaviria, Simon Correa, Shaukat, Tanveer, Kamal, Omer, Wang, Wei, Yang, Heather, Boateng, Jeffery O., Lee, Meghan, Strohbehn, Ian A., Li, Jiahua, Muhsin, Saif A., Mandel, Ernest I., Mueller, Ariel L., Cairl, Nicholas S., Madhani-Lovely, Farah, Rowan, Chris, Madhai-Lovely, Farah, Peev, Vasil, Reiser, Jochen, Byun, John J., Vissing, Andrew, Kapania, Esha M., Post, Zoe, Patel, Nilam P., Hermes, Joy-Marie, Sutherland, Anne K., Patrawalla, Amee, Finkel, Diana G., Danek, Barbara A., Arikapudi, Sowminya, Paer, Jeffrey M., Radbel, Jared, Puri, Sonika, Sunderram, Jag, Scharf, Matthew T., Ahmed, Ayesha, Berim, Ilya, Vatson, Jayanth, Anand, Shuchi, Levitt, Joseph E., Garcia, Pablo, Boyle, Suzanne M., Song, Rui, Zhang, Jingjing, Sharshir, Moh’d A., Rusnak, Vadym V., Bansal, Anip, Podoll, Amber S., Chonchol, Michel, Sharma, Sunita, Burnham, Ellen L., Rashidi, Arash, Hejal, Rana, Judd, Eric, Latta, Laura, Tolwani, Ashita, Albertson, Timothy E., Adams, Jason Y., Chang, Steven Y., Beutler, Rebecca M., Schulze, Carl E., Macedo, Etienne, Rhee, Harin, Liu, Kathleen D., Jotwani, Vasantha K., Koyner, Jay L., Shah, Chintan V., Jaikaransingh, Vishal, Toth-Manikowski, Stephanie M., Joo, Min J., Lash, James P., Neyra, Javier A., Chaaban, Nourhan, Iardino, Alfredo, Au, Elizabeth H., Sharma, Jill H., Anne Sosa, Marie, Taldone, Sabrina, Contreras, Gabriel, De La Zerda, David, Gershengorn, Hayley B., Hayek, Salim S., Blakely, Pennelope, Berlin, Hanna, Azam, Tariq U., Shadid, Husam, Pan, Michael, Hayer, Patrick O’, Meloche, Chelsea, Feroze, Rafey, Padalia, Kishan J., Leya, Jeff, Donnelly, John P., Admon, Andrew J., Flythe, Jennifer E., Tugman, Matthew J., Brown, Brent R., Leonberg-Yoo, Amanda K., Spiardi, Ryan C., Miano, Todd A., Roche, Meaghan S., Vasquez, Charles R., Bansal, Amar D., Ernecoff, Natalie C., Kovesdy, Csaba P., Molnar, Miklos Z., Hedayati, S. Susan, Nadamuni, Mridula V., Khan, Sadaf S., Willett, Duwayne L., Short, Samuel A.P., Renaghan, Amanda D., Bhatraju, Pavan, Malik, A. Bilal, Semler, Matthew W., Vijayan, Anitha, Mariyam Joy, Christina, Li, Tingting, Goldberg, Seth, Kao, Patricia F., Schumaker, Greg L., Goyal, Nitender, Faugno, Anthony J., Schumaker, Greg L., Hsu, Caroline M., Tariq, Asma, Meyer, Leah, Christov, Marta, Wilson, Francis P., Arora, Tanima, and Ugwuowo, Ugochukwu

Published
2021
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8. Outcomes of critically ill solid organ transplant patients with COVID-19 in the United States

Author

Molnar, Miklos Z., Bhalla, Anshul, Azhar, Ambreen, Tsujita, Makoto, Talwar, Manish, Balaraman, Vasanthi, Sodhi, Amik, Kadaria, Dipen, Eason, James D., Hayek, Salim S., Coca, Steven G., Shaefi, Shahzad, Neyra, Javier A., Gupta, Shruti, Leaf, David E., Kovesdy, Csaba P., Walther, Carl P., Anumudu, Samaya J., Arunthamakun, Justin, Kopecky, Kathleen F., Milligan, Gregory P., McCullough, Peter A., Nguyen, Thuy‐Duyen, Krajewski, Megan L., Shankar, Sidharth, Pannu, Ameeka, Valencia, Juan D., Waikar, Sushrut S., Kibbelaar, Zoe A., Athavale, Ambarish M., Hart, Peter, Upadhyay, Shristi, Vohra, Ishaan, Oyintayo, Ajiboye, Green, Adam, Rachoin, Jean‐Sebastien, Schorr, Christa A., Shea, Lisa, Edmonston, Daniel L., Mosher, Christopher L., Shehata, Alexandre M, Cohen, Zaza, Allusson, Valerie, Bambrick‐Santoyo, Gabriela, Bhatti, Noor ul aain, Mehta, Bijal, Williams, Aquino, Brenner, Samantha K., Walters, Patricia, Go, Ronaldo C., Rose, Keith M., Hernán, Miguel A., Lisk, Rebecca, Zhou, Amy M., Kim, Ethan C., Chan, Lili, Mathews, Kusum S., Altman, Deena R., Saha, Aparna, Soh, Howard, Wen, Huei Hsun, Bose, Sonali, Leven, Emily A., Wang, Jing G., Mosoyan, Gohar, Nadkarni, Girish N., Pattharanitima, Pattharawin, Gallagher, Emily J., Friedman, Allon N., Guirguis, John, Kapoor, Rajat, Meshberger, Christopher, Kelly, Katherine J., Parikh, Chirag R., Garibaldi, Brian T., Corona‐Villalobos, Celia P., Wen, Yumeng, Menez, Steven, Malik, Rubab F., Cervantes, Carmen Elena, Gautam, Samir C., Mallappallil, Mary C., Ouyang, Jie, John, Sabu, Yap, Ernie, Melaku, Yohannes, Mohamed, Ibrahim, Bajracharya, Siddhartha, Puri, Isha, Thaxton, Mariah, Bhattacharya, Jyotsna, Wagner, John, Boudourakis, Leon, Nguyen, H. Bryant, Ahoubim, Afshin, Kashani, Kianoush, Tehranian, Shahrzad, Thomas, Leslie F., Sirganagari, Dheeraj Reddy, Guru, Pramod K., Zhou, Yan, Bergl, Paul A., Rodriguez, Jesus, Shah, Jatan A., Gupta, Mrigank S., Kumar, Princy N., Lazarous, Deepa G., Kassaye, Seble G., Melamed, Michal L., Johns, Tanya S., Mocerino, Ryan, Prudhvi, Kalyan, Zhu, Denzel, Levy, Rebecca V., Azzi, Yorg, Fisher, Molly, Yunes, Milagros, Sedaliu, Kaltrina, Golestaneh, Ladan, Brogan, Maureen, Kumar, Neelja, Chang, Michael, Thakkar, Jyotsana, Raichoudhury, Ritesh, Athreya, Akshay, Farag, Mohamed, Schenck, Edward J., Cho, Soo Jung, Plataki, Maria, Alvarez‐Mulett, Sergio L., Gomez‐Escobar, Luis G., Pan, Di, Lee, Stefi, Krishnan, Jamuna, Whalen, William, Charytan, David, Macina, Ashley, Chaudhry, Sobaata, Wu, Benjamin, Modersitzki, Frank, Srivastava, Anand, Leidner, Alexander, Martinez, Carlos, Kruser, Jacqueline M., Wunderink, Richard G., Hodakowski, Alexander J., Velez, Juan Carlos Q., Price‐Haywood, Eboni G., Matute‐Trochez, Luis A., Hasty, Anna E., Mohamed, Muner MB, Avasare, Rupali S., Zonies, David, Leaf, David E, Sise, Meghan E., Newman, Erik T., Omar, Samah Abu, Pokharel, Kapil K., Sharma, Shreyak, Singh, Harkarandeep, Correa, Simon, Shaukat, Tanveer, Kamal, Omer, Wang, Wei, Yang, Heather, Boateng, Jeffery O., Lee, Meghan, Strohbehn, Ian A., Li, Jiahua, Mueller, Ariel L., Redfern, Roberta E., Cairl, Nicholas S., Naimy, Gabriel, Abu‐Saif, Abeer, Hall, Danyell, Bickley, Laura, Rowan, Chris, Madhani‐Lovely, Farah, Peev, Vasil, Reiser, Jochen, Byun, John J., Vissing, Andrew, Kapania, Esha M., Post, Zoe, Patel, Nilam P., Hermes, Joy‐Marie, Sutherland, Anne K., Patrawalla, Amee, Finkel, Diana G., Danek, Barbara A., Arikapudi, Sowminya, Paer, Jeffrey M., Cangialosi, Peter, Liotta, Mark, Radbel, Jared, Puri, Sonika, Sunderram, Jag, Scharf, Matthew T., Ahmed, Ayesha, Berim, Ilya, Vatson, Jayanth S., Anand, Shuchi, Levitt, Joseph E., Garcia, Pablo, Boyle, Suzanne M., Song, Rui, Arif, Ali, Zhang, Jingjing, Woo, Sang Hoon, Deng, Xiaoying, Katz‐Greenberg, Goni, Senter, Katharine, Sharshir, Moh’d A., Rusnak, Vadym V, Ali, Muhammad Imran, Peters, Terri, Hughes, Kathy, Bansal, Anip, Podoll, Amber S., Chonchol, Michel, Sharma, Sunita, Burnham, Ellen L., Douin, David J., Rashidi, Arash, Hejal, Rana, Judd, Eric, Latta, Laura, Tolwani, Ashita, Albertson, Timothy E., Adams, Jason Y., Chang, Steven Y., Beutler, Rebecca M., Schulze, Carl E., Macedo, Etienne, Rhee, Harin, Liu, Kathleen D., Jotwani, Vasantha K., Koyner, Jay L., Shah, Chintan V., Jaikaransingh, Vishal, Toth‐Manikowski, Stephanie M., Joo, Min J., Lash, James P., Chaaban, Nourhan, Elias, Madona, Ahmad, Yahya, Iardino, Alfredo, Au, Elizabeth H., Sharma, Jill H., Sosa, Marie Anne, Taldone, Sabrina, Contreras, Gabriel, Zerda, David De La, Fornoni, Alessia, Gershengorn, Hayley B., Blakely, Pennelope, Berlin, Hanna, Azam, Tariq U., Shadid, Husam, Pan, Michael, Hayer, Patrick O’, Meloche, Chelsea, Feroze, Rafey, Kishan J. Padalia, Bitar, Abbas, Leya, Jeff, Donnelly, John P., Admon, Andrew J., Flythe, Jennifer E., Tugman, Matthew J., Chang, Emily H., Brown, Brent R., Leonberg‐Yoo, Amanda K., Spiardi, Ryan C., Miano, Todd A., Roche, Meaghan S., Vasquez, Charles R., Bansal, Amar D., Ernecoff, Natalie C., Kapoor, Sanjana, Verma, Siddharth, Chen, Huiwen, Hedayati, S. Susan, Nadamuni, Mridula V., Shastri, Shani, Willett, Duwayne L., Short, Samuel A.P., Renaghan, Amanda D., Enfield, Kyle B., Bhatraju, Pavan K., Malik, A. Bilal, Semler, Matthew W., Vijayan, Anitha, Joy, Christina Mariyam, Li, Tingting, Goldberg, Seth, Kao, Patricia F., Schumaker, Greg L., Goyal, Nitender, Faugno, Anthony J., Hsu, Caroline M., Tariq, Asma, Meyer, Leah, Kshirsagar, Ravi K., Jose, Aju, Weiner, Daniel E., Christov, Marta, Griffiths, Jennifer, Gupta, Sanjeev, Kapoor, Aromma, Wilson, Perry, Arora, Tanima, and Ugwuowo, Ugochukwu

Subjects
Male, medicine.medical_specialty, Critical Illness, medicine.medical_treatment, Comorbidity, 030230 surgery, Organ transplantation, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Intensive care, medicine, Humans, Immunology and Allergy, Pharmacology (medical), Hospital Mortality, Renal replacement therapy, Pandemics, Survival rate, Aged, Transplantation, SARS-CoV-2, business.industry, Acute kidney injury, COVID-19, Original Articles, Organ Transplantation, Middle Aged, medicine.disease, United States, Hospitalization, Survival Rate, Intensive Care Units, Relative risk, Propensity score matching, Original Article, Female, business, Follow-Up Studies, Cohort study
Abstract

National data on patient characteristics, treatment, and outcomes of critically ill coronavirus disease 2019 (COVID-19) solid organ transplant (SOT) patients are limited. We analyzed data from a multicenter cohort study of adults with laboratory-confirmed COVID-19 admitted to intensive care units (ICUs) at 68 hospitals across the United States from March 4 to May 8, 2020. From 4153 patients, we created a propensity score matched cohort of 386 patients, including 98 SOT patients and 288 non-SOT patients. We used a binomial generalized linear model (log-binomial model) to examine the association of SOT status with death and other clinical outcomes. Among the 386 patients, the median age was 60 years, 72% were male, and 41% were black. Death within 28 days of ICU admission was similar in SOT and non-SOT patients (40% and 43%, respectively; relative risk [RR] 0.92; 95% confidence interval [CI]: 0.70-1.22). Other outcomes and requirement for organ support including receipt of mechanical ventilation, development of acute respiratory distress syndrome, and receipt of vasopressors were also similar between groups. There was a trend toward higher risk of acute kidney injury requiring renal replacement therapy in SOT vs. non-SOT patients (37% vs. 27%; RR [95% CI]: 1.34 [0.97-1.85]). Death and organ support requirement were similar between SOT and non-SOT critically ill patients with COVID-19.

Published
2020

10. Association of Surge Conditions with Mortality Among Critically Ill Patients with COVID-19

Author

Keene, Adam B., primary, Admon, Andrew J., additional, Brenner, Samantha K., additional, Gupta, Shruti, additional, Lazarous, Deepa, additional, Leaf, David E., additional, Gershengorn, Hayley B., additional, Walther, Carl P., additional, Anumudu, Samaya J., additional, Arunthamakun, Justin, additional, Kopecky, Kathleen F., additional, Milligan, Gregory P., additional, McCullough, Peter A., additional, Nguyen, Thuy-Duyen, additional, Shaefi, Shahzad, additional, O’Gara, Brian P., additional, Krajewski, Megan L., additional, Baskin, Sean M., additional, Shankar, Sidharth, additional, Valencia, Juan D., additional, Pannu, Ameeka, additional, Hayes, Margaret M., additional, Grandin, E. Wilson, additional, Waikar, Sushrut S., additional, Kibbelaar, Zoe A., additional, Athavale, Ambarish M., additional, Hart, Peter, additional, Upadhyay, Shristi, additional, Vohra, Ishaan, additional, Oyintayo, Ajiboye, additional, Green, Adam, additional, Rachoin, Jean-Sebastien, additional, Schorr, Christa A., additional, Shea, Lisa, additional, Edmonston, Daniel L., additional, Mosher, Christopher L., additional, Shehata, Alexandre M., additional, Cohen, Zaza, additional, Allusson, Valerie, additional, Bambrick-Santoyo, Gabriela, additional, ul aain Bhatti, Noor, additional, Mehta, Bijal, additional, Williams, Aquino, additional, Walters, Patricia, additional, Go, Ronaldo C., additional, Rose, Keith M., additional, Hernán;, Miguel A., additional, Lisk, Rebecca, additional, Chan, Lili, additional, Mathews, Kusum S., additional, Coca, Steven G., additional, Altman, Deena R., additional, Saha, Aparna, additional, Soh, Howard, additional, Wen, Huei Hsun, additional, Bose, Sonali, additional, Leven, Emily A., additional, Wang, Jing G., additional, Mosoyan, Gohar, additional, Nadkarni, Girish N., additional, Pattharanitima, Pattharawin, additional, Gallagher, Emily J., additional, Friedman, Allon N., additional, Guirguis, John, additional, Kapoor, Rajat, additional, Meshberger, Christopher, additional, Kelly, Katherine J., additional, Parikh, Chirag R., additional, Garibaldi, Brian T., additional, Corona-Villalobos, Celia P., additional, Wen, Yumeng, additional, Menez, Steven, additional, Malik, Rubab F., additional, Elena Cervantes, Carmen, additional, Gautam, Samir C., additional, Mallappallil, Mary C., additional, Ouyang, Jie, additional, John, Sabu, additional, Yap, Ernie, additional, Melaku, Yohannes, additional, Mohamed, Ibrahim, additional, Bajracharya, Siddhartha, additional, Puri, Isha, additional, Thaxton, Mariah, additional, Bhattacharya, Jyotsna, additional, Wagner, John, additional, Boudourakis, Leon, additional, Nguyen, H. Bryant, additional, Ahoubim, Afshin, additional, Thomas, Leslie F., additional, Sirganagari, Dheeraj Reddy, additional, Guru, Pramod K., additional, Kashani, Kianoush, additional, Tehranian, Shahrzad, additional, Zhou, Yan, additional, Bergl, Paul A., additional, Rodriguez, Jesus, additional, Shah, Jatan A., additional, Gupta, Mrigank S., additional, Kumar, Princy N., additional, Lazarous, Deepa G., additional, Kassaye, Seble G., additional, Melamed, Michal L., additional, Johns, Tanya S., additional, Mocerino, Ryan, additional, Prudhvi, Kalyan, additional, Zhu, Denzel, additional, Levy, Rebecca V., additional, Azzi, Yorg, additional, Fisher, Molly, additional, Yunes, Milagros, additional, Sedaliu, Kaltrina, additional, Golestaneh, Ladan, additional, Brogan, Maureen, additional, Kumar, Neelja, additional, Chang, Michael, additional, Thakkar, Jyotsana, additional, Raichoudhury, Ritesh, additional, Athreya, Akshay, additional, Farag, Mohamed, additional, Schenck, Edward J., additional, Jung Cho, Soo, additional, Plataki, Maria, additional, Alvarez-Mulett, Sergio L., additional, Gomez-Escobar, Luis G., additional, Pan, Di, additional, Lee, Stefi, additional, Krishnan, Jamuna, additional, Whalen, William, additional, Charytan, David, additional, Macina, Ashley, additional, Chaudhry, Sobaata, additional, Wu, Benjamin, additional, Modersitzki, Frank, additional, Srivastava, Anand, additional, Leidner, Alexander S., additional, Martinez, Carlos, additional, Kruser, Jacqueline M., additional, Wunderink, Richard G., additional, Hodakowski, Alexander J., additional, Velez, Juan Carlos Q., additional, Price-Haywood, Eboni G., additional, Matute-Trochez, Luis A., additional, Hasty, Anna E., additional, Mohamed, Muner MB., additional, Avasare, Rupali S., additional, Zonies, David, additional, Sise, Meghan E., additional, Newman, Erik T., additional, Abu Omar, Samah, additional, Pokharel, Kapil K., additional, Sharma, Shreyak, additional, Singh, Harkarandeep, additional, Correa, Simon, additional, Shaukat, Tanveer, additional, Kamal, Omer, additional, Wang, Wei, additional, Yang, Heather, additional, Boateng, Jeffery O., additional, Lee, Meghan, additional, Strohbehn, Ian A., additional, Li, Jiahua, additional, Mueller, Ariel L., additional, Redfern, Roberta E., additional, Cairl, Nicholas S., additional, Naimy, Gabriel, additional, Abu-Saif, Abeer, additional, Hall, Danyell, additional, Bickley, Laura, additional, Rowan, Chris, additional, Madhani-Lovely, Farah, additional, Peev, Vasil, additional, Reiser, Jochen, additional, Byun, John J., additional, Vissing, Andrew, additional, Kapania, Esha M., additional, Post, Zoe, additional, Patel, Nilam P., additional, Hermes, Joy-Marie, additional, Sutherland, Anne K., additional, Patrawalla, Amee, additional, Finkel, Diana G., additional, Danek, Barbara A., additional, Arikapudi, Sowminya, additional, Paer, Jeffrey M., additional, Cangialosi, Peter, additional, Liotta, Mark, additional, Radbel, Jared, additional, Puri, Sonika, additional, Sunderram, Jag, additional, Scharf, Matthew T., additional, Ahmed, Ayesha, additional, Berim, Ilya, additional, Vatson, Jayanth S., additional, Anand, Shuchi, additional, Levitt, Joseph E., additional, Garcia, Pablo, additional, Boyle, Suzanne M., additional, Song, Rui, additional, Arif, Ali, additional, Zhang, Jingjing, additional, Woo, Sang Hoon, additional, Deng, Xiaoying, additional, Katz-Greenberg, Goni, additional, Senter, Katharine, additional, Sharshir, Moh’d A., additional, Rusnak, Vadym V., additional, Imran Ali, Muhammad, additional, Peters, Terri, additional, Hughes, Kathy, additional, Bansal, Anip, additional, Podoll, Amber S., additional, Chonchol, Michel, additional, Sharma, Sunita, additional, Burnham, Ellen L., additional, Rashidi, Arash, additional, Hejal, Rana, additional, Judd, Eric, additional, Latta, Laura, additional, Tolwani, Ashita, additional, Albertson, Timothy E., additional, Adams, Jason Y., additional, Chang, Steven Y., additional, Beutler, Rebecca M., additional, Schulze, Carl E., additional, Macedo, Etienne, additional, Rhee, Harin, additional, Liu, Kathleen D., additional, Jotwani, Vasantha K., additional, Koyner, Jay L., additional, Kunczt, Alissa, additional, Shah, Chintan V., additional, Jaikaransingh, Vishal, additional, Toth-Manikowski, Stephanie M., additional, Joo, Min J., additional, Lash, James P., additional, Neyra, Javier A., additional, Chaaban, Nourhan, additional, Elias, Madona, additional, Ahmad, Yahya, additional, Dy, Rajany, additional, Iardino, Alfredo, additional, Au, Elizabeth H., additional, Sharma, Jill H., additional, Anne Sosa, Marie, additional, Taldone, Sabrina, additional, Contreras, Gabriel, additional, De La Zerda, David, additional, Fornoni, Alessia, additional, Hayek, Salim S., additional, Blakely, Pennelope, additional, Berlin, Hanna, additional, Azam, Tariq U., additional, Shadid, Husam, additional, Pan, Michael, additional, O” Hayer, Patrick, additional, Meloche, Chelsea, additional, Feroze, Rafey, additional, Padalia, Kishan J., additional, Bitar, Abbas, additional, Leya, Jeff, additional, Donnelly, John P., additional, Flythe, Jennifer E., additional, Tugman, Matthew J., additional, Chang, Emily H., additional, Brown, Brent R., additional, Leonberg-Yoo, Amanda K., additional, Spiardi, Ryan C., additional, Miano, Todd A., additional, Roche, Meaghan S., additional, Vasquez, Charles R., additional, Bansal, Amar D., additional, Ernecoff, Natalie C., additional, Kapoor, Sanjana, additional, Verma, Siddharth, additional, Chen, Huiwen, additional, Kovesdy, Csaba P., additional, Molnar, Miklos Z., additional, Azhar, Ambreen, additional, Susan Hedayati, S., additional, Nadamuni, Mridula V., additional, Shastri, Shani, additional, Willett, Duwayne L., additional, Short, Samuel A.P., additional, Renaghan, Amanda D., additional, Enfield, Kyle B., additional, Bhatraju, Pavan K., additional, Bilal Malik, A., additional, Semler, Matthew W., additional, Vijayan, Anitha, additional, Mariyam Joy, Christina, additional, Li, Tingting, additional, Goldberg, Seth, additional, Kao, Patricia F., additional, Schumaker, Greg L., additional, Goyal, Nitender, additional, Faugno, Anthony J., additional, Hsu, Caroline M., additional, Tariq, Asma, additional, Meyer, Leah, additional, Kshirsagar, Ravi K., additional, Jose, Aju, additional, Weiner, Daniel E., additional, Christov, Marta, additional, Chugh, Savneek, additional, Griffiths, Jennifer, additional, Gupta, Sanjeev, additional, Kapoor, Aromma, additional, Wilson, Perry, additional, Arora, Tanima, additional, and Ugwuowo, Ugochukwu, additional

Published
2021
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11. Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States

Author

Walther, Carl P., Anumudu, Samaya J., Arunthamakun, Justin, Kopecky, Kathleen F., Milligan, Gregory P., McCullough, Peter A., Nguyen, Thuy-Duyen, Shaefi, Shahzad, Krajewski, Megan L., Shankar, Sidharth, Pannu, Ameeka, Valencia, Juan D., Waikar, Sushrut S., Kibbelaar, Zoe A., Athavale, Ambarish M., Hart, Peter, Upadhyay, Shristi, Vohra, Ishaan, Oyintayo, Ajiboye, Green, Adam, Rachoin, Jean-Sebastien, Schorr, Christa A., Shea, Lisa, Edmonston, Daniel L., Mosher, Christopher L., Shehata, Alexandre M., Cohen, Zaza, Allusson, Valerie, Bambrick-Santoyo, Gabriela, ul aain Bhatti, Noor, Mehta, Bijal, Williams, Aquino, Brenner, Samantha K., Walters, Patricia, Go, Ronaldo C., Rose, Keith M., Hernán, Miguel A., Zhou, Amy M., Kim, Ethan C., Lisk, Rebecca, Chan, Lili, Mathews, Kusum S., Coca, Steven G., Altman, Deena R., Saha, Aparna, Soh, Howard, Wen, Huei Hsun, Bose, Sonali, Leven, Emily A., Wang, Jing G., Mosoyan, Gohar, Nadkarni, Girish N., Pattharanitima, Pattharawin, Friedman, Allon N., Guirguis, John, Kapoor, Rajat, Meshberger, Christopher, Kelly, Katherine J., Parikh, Chirag R., Garibaldi, Brian T., Corona-Villalobos, Celia P., Wen, Yumeng, Menez, Steven, Malik, Rubab F., Cervantes, Elena, Gautam, Samir, Mallappallil, Mary C., Ouyang, Jie, John, Sabu, Yap, Ernie, Melaku, Yohannes, Mohamed, Ibrahim, Bajracharya, Siddartha, Puri, Isha, Thaxton, Mariah, Bhattacharya, Jyotsna, Wagner, John, Boudourakis, Leon, Nguyen, H. Bryant, Ahoubim, Afshin, Thomas, Leslie F., Sirganagari, Dheeraj Reddy, Guru, Pramod K., Kashani, Kianoush, Zhou, Yan, Bergl, Paul A., Rodriguez, Jesus, Shah, Jatan A., Gupta, Mrigank S., Kumar, Princy N., Lazarous, Deepa G., Kassaye, Seble G., Melamed, Michal L., Johns, Tanya S., Mocerino, Ryan, Prudhvi, Kalyan, Zhu, Denzel, Levy, Rebecca V., Azzi, Yorg, Fisher, Molly, Yunes, Milagros, Sedaliu, Kaltrina, Golestaneh, Ladan, Brogan, Maureen, Kumar, Neelja, Chang, Michael, Raichoudhury, Ritesh, Athreya, Akshay, Farag, Mohamed, Schenck, Edward J., Cho, Soo Jung, Plataki, Maria, Alvarez-Mulett, Sergio L., Gomez-Escobar, Luis G., Pan, Di, Lee, Stefi, Krishnan, Jamuna, Whalen, William, Charytan, David, Macina, Ashley, Chaudhry, Sobaata, Wu, Benjamin, Modersitzki, Frank, Srivastava, Anand, Leidner, Alexander S., Martinez, Carlos, Kruser, Jacqueline M., Wunderink, Richard G., Hodakowski, Alexander J., Velez, Juan Carlos Q., Price-Haywood, Eboni G., Matute-Trochez, Luis A., Hasty, Anna E., Mohamed, Muner MB., Avasare, Rupali S., Zonies, David, Leaf, David E., Gupta, Shruti, Sise, Meghan E., Newman, Erik T., Abu Omar, Samah, Pokharel, Kapil K., Sharma, Shreyak, Singh, Harkarandeep, Correa, Simon, Shaukat, Tanveer, Kamal, Omer, Wang, Wei, Yang, Heather, Boateng, Jeffery O., Lee, Meghan, Strohbehn, Ian A., Li, Jiahua, Mueller, Ariel L., Redfern, Roberta, Cairl, Nicholas S., Naimy, Gabriel, Abu-Saif, Abeer, Hall, Danyell, Bickley, Laura, Rowan, Chris, Madhani-Lovely, Farah, Cruz, Vivian S., Hess, Kristen M., Jacobs, Alanna L., Peev, Vasil, Reiser, Jochen, Byun, John J., Vissing, Andrew, Kapania, Esha M., Post, Zoe, Patel, Nilam P., Hermes, Joy-Marie, Sutherland, Anne K., Patrawalla, Amee, Finkel, Diana G., Danek, Barbara A., Arikapudi, Sowminya, Paer, Jeffrey M., Cangialosi, Peter, Liotta, Mark, Radbel, Jared, Puri, Sonika, Sunderram, Jag, Scharf, Matthew T., Ahmed, Ayesha, Berim, Ilya, Vatson, Jayanth S., Anand, Shuchi, Levitt, Joseph E., Boyle, Suzanne M., Song, Rui, Zhang, Jingjing, Woo, Sang Hoon, Deng, Xiaoying, Katz-Greenberg, Goni, Senter, Katharine, Sharshir, Moh’d A., Rusnak, Vadym V., Ali, Muhammad Imran, Bansal, Anip, Podoll, Amber S., Chonchol, Michel, Sharma, Sunita, Burnham, Ellen L., Rashidi, Arash, Hejal, Rana, Judd, Eric, Latta, Laura, Tolwani, Ashita, Albertson, Timothy E., Adams, Jason Y., Chang, Steven Y., Beutler, Rebecca M., Macedo, Etienne, Rhee, Harin, Liu, Kathleen D., Jotwani, Vasantha K., Koyner, Jay L., Shah, Chintan V., Jaikaransingh, Vishal, Toth-Manikowski, Stephanie M., Joo, Min J., Lash, James P., Neyra, Javier A., Chaaban, Nourhan, Elias, Madona, Ahmad, Yahya, Iardino, Alfredo, Au, Elizabeth H., Sharma, Jill H., Sosa, Marie Anne, Taldone, Sabrina, Contreras, Gabriel, De La Zerda, David, Gershengorn, Hayley B., Shukla, Bhavarth, Fornoni, Alessia, Ferreira, Tanira, Hayek, Salim S., Blakely, Pennelope, Berlin, Hanna, Azam, Tariq U., Shadid, Husam, Pan, Michael, O’ Hayer, Patrick, Meloche, Chelsea, Feroze, Rafey, Kaakati, Rayan, Perry, Danny, Bitar, Abbas, Anderson, Elizabeth, Padalia, Kishan J., Donnelly, John P., Admon, Andrew J., Flythe, Jennifer E., Tugman, Matthew J., Chang, Emily H., Brown, Brent R., Leonberg-Yoo, Amanda K., Spiardi, Ryan C., Miano, Todd A., Roche, Meaghan S., Vasquez, Charles R., Bansal, Amar D., Ernecoff, Natalie C., Kapoor, Sanjana, Verma, Siddharth, Kovesdy, Csaba P., Molnar, Miklos Z., Azhar, Ambreen, Hedayati, S. Susan, Nadamuni, Mridula V., Shastri, Shani, Willett, Duwayne L., Short, Samuel A.P., Renaghan, Amanda D., Enfield, Kyle B., Bhatraju, Pavan K., Malik, A. Bilal, Semler, Matthew W., Vijayan, Anitha, Joy, Christina Mariyam, Li, Tingting, Goldberg, Seth, Kao, Patricia F., Schumaker, Greg L., Goyal, Nitender, Faugno, Anthony J., Hsu, Caroline M., Tariq, Asma, Meyer, Leah, Kshirsagar, Ravi K., Weiner, Daniel E., Jose, Aju, Christov, Marta, Griffiths, Jennifer, Gupta, Sanjeev, Kapoor, Aromma, Wilson, Perry, Arora, Tanima, Ugwuowo, Ugochukwu, Jezmir, Julia L., Bharadwaj, Maheetha, Chaitoff, Alexander, Diephuis, Bradford, Crowley, Conor P., Kishore, Sandeep P., Goralnick, Eric, Merriam, Louis T., Milliken, Aimee, Rhee, Chanu, Sadovnikoff, Nicholas, Shah, Sejal B., Feldman, William B., and Kim, Edy Y.

Published
2021
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12. Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States

Author

Jezmir, Julia L., primary, Bharadwaj, Maheetha, additional, Chaitoff, Alexander, additional, Diephuis, Bradford, additional, Crowley, Conor P., additional, Kishore, Sandeep P., additional, Goralnick, Eric, additional, Merriam, Louis T., additional, Milliken, Aimee, additional, Rhee, Chanu, additional, Sadovnikoff, Nicholas, additional, Shah, Sejal B., additional, Gupta, Shruti, additional, Leaf, David E., additional, Feldman, William B., additional, Kim, Edy Y., additional, Walther, Carl P., additional, Anumudu, Samaya J., additional, Arunthamakun, Justin, additional, Kopecky, Kathleen F., additional, Milligan, Gregory P., additional, McCullough, Peter A., additional, Nguyen, Thuy-Duyen, additional, Shaefi, Shahzad, additional, Krajewski, Megan L., additional, Shankar, Sidharth, additional, Pannu, Ameeka, additional, Valencia, Juan D., additional, Waikar, Sushrut S., additional, Kibbelaar, Zoe A., additional, Athavale, Ambarish M., additional, Hart, Peter, additional, Upadhyay, Shristi, additional, Vohra, Ishaan, additional, Oyintayo, Ajiboye, additional, Green, Adam, additional, Rachoin, Jean-Sebastien, additional, Schorr, Christa A., additional, Shea, Lisa, additional, Edmonston, Daniel L., additional, Mosher, Christopher L., additional, Shehata, Alexandre M., additional, Cohen, Zaza, additional, Allusson, Valerie, additional, Bambrick-Santoyo, Gabriela, additional, ul aain Bhatti, Noor, additional, Mehta, Bijal, additional, Williams, Aquino, additional, Brenner, Samantha K., additional, Walters, Patricia, additional, Go, Ronaldo C., additional, Rose, Keith M., additional, Hernán, Miguel A., additional, Zhou, Amy M., additional, Kim, Ethan C., additional, Lisk, Rebecca, additional, Chan, Lili, additional, Mathews, Kusum S., additional, Coca, Steven G., additional, Altman, Deena R., additional, Saha, Aparna, additional, Soh, Howard, additional, Wen, Huei Hsun, additional, Bose, Sonali, additional, Leven, Emily A., additional, Wang, Jing G., additional, Mosoyan, Gohar, additional, Nadkarni, Girish N., additional, Pattharanitima, Pattharawin, additional, Friedman, Allon N., additional, Guirguis, John, additional, Kapoor, Rajat, additional, Meshberger, Christopher, additional, Kelly, Katherine J., additional, Parikh, Chirag R., additional, Garibaldi, Brian T., additional, Corona-Villalobos, Celia P., additional, Wen, Yumeng, additional, Menez, Steven, additional, Malik, Rubab F., additional, Cervantes, Elena, additional, Gautam, Samir, additional, Mallappallil, Mary C., additional, Ouyang, Jie, additional, John, Sabu, additional, Yap, Ernie, additional, Melaku, Yohannes, additional, Mohamed, Ibrahim, additional, Bajracharya, Siddartha, additional, Puri, Isha, additional, Thaxton, Mariah, additional, Bhattacharya, Jyotsna, additional, Wagner, John, additional, Boudourakis, Leon, additional, Nguyen, H. Bryant, additional, Ahoubim, Afshin, additional, Thomas, Leslie F., additional, Sirganagari, Dheeraj Reddy, additional, Guru, Pramod K., additional, Kashani, Kianoush, additional, Zhou, Yan, additional, Bergl, Paul A., additional, Rodriguez, Jesus, additional, Shah, Jatan A., additional, Gupta, Mrigank S., additional, Kumar, Princy N., additional, Lazarous, Deepa G., additional, Kassaye, Seble G., additional, Melamed, Michal L., additional, Johns, Tanya S., additional, Mocerino, Ryan, additional, Prudhvi, Kalyan, additional, Zhu, Denzel, additional, Levy, Rebecca V., additional, Azzi, Yorg, additional, Fisher, Molly, additional, Yunes, Milagros, additional, Sedaliu, Kaltrina, additional, Golestaneh, Ladan, additional, Brogan, Maureen, additional, Kumar, Neelja, additional, Chang, Michael, additional, Raichoudhury, Ritesh, additional, Athreya, Akshay, additional, Farag, Mohamed, additional, Schenck, Edward J., additional, Cho, Soo Jung, additional, Plataki, Maria, additional, Alvarez-Mulett, Sergio L., additional, Gomez-Escobar, Luis G., additional, Pan, Di, additional, Lee, Stefi, additional, Krishnan, Jamuna, additional, Whalen, William, additional, Charytan, David, additional, Macina, Ashley, additional, Chaudhry, Sobaata, additional, Wu, Benjamin, additional, Modersitzki, Frank, additional, Srivastava, Anand, additional, Leidner, Alexander S., additional, Martinez, Carlos, additional, Kruser, Jacqueline M., additional, Wunderink, Richard G., additional, Hodakowski, Alexander J., additional, Velez, Juan Carlos Q., additional, Price-Haywood, Eboni G., additional, Matute-Trochez, Luis A., additional, Hasty, Anna E., additional, Mohamed, Muner MB., additional, Avasare, Rupali S., additional, Zonies, David, additional, Sise, Meghan E., additional, Newman, Erik T., additional, Abu Omar, Samah, additional, Pokharel, Kapil K., additional, Sharma, Shreyak, additional, Singh, Harkarandeep, additional, Correa, Simon, additional, Shaukat, Tanveer, additional, Kamal, Omer, additional, Wang, Wei, additional, Yang, Heather, additional, Boateng, Jeffery O., additional, Lee, Meghan, additional, Strohbehn, Ian A., additional, Li, Jiahua, additional, Mueller, Ariel L., additional, Redfern, Roberta, additional, Cairl, Nicholas S., additional, Naimy, Gabriel, additional, Abu-Saif, Abeer, additional, Hall, Danyell, additional, Bickley, Laura, additional, Rowan, Chris, additional, Madhani-Lovely, Farah, additional, Cruz, Vivian S., additional, Hess, Kristen M., additional, Jacobs, Alanna L., additional, Peev, Vasil, additional, Reiser, Jochen, additional, Byun, John J., additional, Vissing, Andrew, additional, Kapania, Esha M., additional, Post, Zoe, additional, Patel, Nilam P., additional, Hermes, Joy-Marie, additional, Sutherland, Anne K., additional, Patrawalla, Amee, additional, Finkel, Diana G., additional, Danek, Barbara A., additional, Arikapudi, Sowminya, additional, Paer, Jeffrey M., additional, Cangialosi, Peter, additional, Liotta, Mark, additional, Radbel, Jared, additional, Puri, Sonika, additional, Sunderram, Jag, additional, Scharf, Matthew T., additional, Ahmed, Ayesha, additional, Berim, Ilya, additional, Vatson, Jayanth S., additional, Anand, Shuchi, additional, Levitt, Joseph E., additional, Boyle, Suzanne M., additional, Song, Rui, additional, Zhang, Jingjing, additional, Woo, Sang Hoon, additional, Deng, Xiaoying, additional, Katz-Greenberg, Goni, additional, Senter, Katharine, additional, Sharshir, Moh’d A., additional, Rusnak, Vadym V., additional, Ali, Muhammad Imran, additional, Bansal, Anip, additional, Podoll, Amber S., additional, Chonchol, Michel, additional, Sharma, Sunita, additional, Burnham, Ellen L., additional, Rashidi, Arash, additional, Hejal, Rana, additional, Judd, Eric, additional, Latta, Laura, additional, Tolwani, Ashita, additional, Albertson, Timothy E., additional, Adams, Jason Y., additional, Chang, Steven Y., additional, Beutler, Rebecca M., additional, Macedo, Etienne, additional, Rhee, Harin, additional, Liu, Kathleen D., additional, Jotwani, Vasantha K., additional, Koyner, Jay L., additional, Shah, Chintan V., additional, Jaikaransingh, Vishal, additional, Toth-Manikowski, Stephanie M., additional, Joo, Min J., additional, Lash, James P., additional, Neyra, Javier A., additional, Chaaban, Nourhan, additional, Elias, Madona, additional, Ahmad, Yahya, additional, Iardino, Alfredo, additional, Au, Elizabeth H., additional, Sharma, Jill H., additional, Sosa, Marie Anne, additional, Taldone, Sabrina, additional, Contreras, Gabriel, additional, De La Zerda, David, additional, Gershengorn, Hayley B., additional, Shukla, Bhavarth, additional, Fornoni, Alessia, additional, Ferreira, Tanira, additional, Hayek, Salim S., additional, Blakely, Pennelope, additional, Berlin, Hanna, additional, Azam, Tariq U., additional, Shadid, Husam, additional, Pan, Michael, additional, O’ Hayer, Patrick, additional, Meloche, Chelsea, additional, Feroze, Rafey, additional, Kaakati, Rayan, additional, Perry, Danny, additional, Bitar, Abbas, additional, Anderson, Elizabeth, additional, Padalia, Kishan J., additional, Donnelly, John P., additional, Admon, Andrew J., additional, Flythe, Jennifer E., additional, Tugman, Matthew J., additional, Chang, Emily H., additional, Brown, Brent R., additional, Leonberg-Yoo, Amanda K., additional, Spiardi, Ryan C., additional, Miano, Todd A., additional, Roche, Meaghan S., additional, Vasquez, Charles R., additional, Bansal, Amar D., additional, Ernecoff, Natalie C., additional, Kapoor, Sanjana, additional, Verma, Siddharth, additional, Kovesdy, Csaba P., additional, Molnar, Miklos Z., additional, Azhar, Ambreen, additional, Hedayati, S. Susan, additional, Nadamuni, Mridula V., additional, Shastri, Shani, additional, Willett, Duwayne L., additional, Short, Samuel A.P., additional, Renaghan, Amanda D., additional, Enfield, Kyle B., additional, Bhatraju, Pavan K., additional, Malik, A. Bilal, additional, Semler, Matthew W., additional, Vijayan, Anitha, additional, Joy, Christina Mariyam, additional, Li, Tingting, additional, Goldberg, Seth, additional, Kao, Patricia F., additional, Schumaker, Greg L., additional, Goyal, Nitender, additional, Faugno, Anthony J., additional, Hsu, Caroline M., additional, Tariq, Asma, additional, Meyer, Leah, additional, Kshirsagar, Ravi K., additional, Weiner, Daniel E., additional, Jose, Aju, additional, Christov, Marta, additional, Griffiths, Jennifer, additional, Gupta, Sanjeev, additional, Kapoor, Aromma, additional, Wilson, Perry, additional, Arora, Tanima, additional, and Ugwuowo, Ugochukwu, additional

Published
2021
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13. Identification of Distinct Clinical Subphenotypes in Critically Ill Patients With COVID-19

Author

Vasquez, Charles R., primary, Gupta, Shruti, additional, Miano, Todd A., additional, Roche, Meaghan, additional, Hsu, Jesse, additional, Yang, Wei, additional, Holena, Daniel N., additional, Reilly, John P., additional, Schrauben, Sarah J., additional, Leaf, David E., additional, Shashaty, Michael G.S., additional, Walther, Carl P., additional, Anumudu, Samaya J., additional, Arunthamakun, Justin, additional, Kopecky, Kathleen F., additional, Milligan, Gregory P., additional, McCullough, Peter A., additional, Nguyen, Thuy-Duyen, additional, Shaefi, Shahzad, additional, Krajewski, Megan L., additional, Shankar, Sidharth, additional, Pannu, Ameeka, additional, Valencia, Juan D., additional, Waikar, Sushrut S., additional, Kibbelaar, Zoe A., additional, Athavale, Ambarish M., additional, Hart, Peter, additional, Upadhyay, Shristi, additional, Vohra, Ishaan, additional, Oyintayo, Ajiboye, additional, Green, Adam, additional, Rachoin, Jean-Sebastien, additional, Schorr, Christa A., additional, Shea, Lisa, additional, Edmonston, Daniel L., additional, Mosher, Christopher L., additional, Shehata, Alexandre M., additional, Cohen, Zaza, additional, Allusson, Valerie, additional, Bambrick-Santoyo, Gabriela, additional, Bhatti, Noor ul aain, additional, Mehta, Bijal, additional, Williams, Aquino, additional, Brenner, Samantha K., additional, Walters, Patricia, additional, Go, Ronaldo C., additional, Rose, Keith M., additional, Chan, Lili, additional, Mathews, Kusum S., additional, Coca, Steven G., additional, Altman, Deena R., additional, Saha, Aparna, additional, Soh, Howard, additional, Wen, Huei Hsun, additional, Bose, Sonali, additional, Leven, Emily A., additional, Wang, Jing G., additional, Mosoyan, Gohar, additional, Nadkarni, Girish N., additional, Pattharanitima, Pattharawin, additional, Gallagher, Emily J., additional, Friedman, Allon N., additional, Guirguis, John, additional, Kapoor, Rajat, additional, Meshberger, Christopher, additional, Kelly, Katherine J., additional, Parikh, Chirag R., additional, Garibaldi, Brian T., additional, Corona-Villalobos, Celia P., additional, Wen, Yumeng, additional, Menez, Steven, additional, Malik, Rubab F., additional, Cervantes, Carmen Elena, additional, Gautam, Samir C., additional, Mallappallil, Mary C., additional, Ouyang, Jie, additional, John, Sabu, additional, Yap, Ernie, additional, Melaku, Yohannes, additional, Mohamed, Ibrahim, additional, Bajracharya, Siddhartha, additional, Puri, Isha, additional, Thaxton, Mariah, additional, Bhattacharya, Jyotsna, additional, Wagner, John, additional, Boudourakis, Leon, additional, Nguyen, H. Bryant, additional, Ahoubim, Afshin, additional, Kashani, Kianoush, additional, Tehranian, Shahrzad, additional, Thomas, Leslie F., additional, Sirganagari, Dheeraj Reddy, additional, Guru, Pramod K., additional, Zhou, Yan, additional, Bergl, Paul A., additional, Rodriguez, Jesus, additional, Shah, Jatan A., additional, Gupta, Mrigank S., additional, Kumar, Princy N., additional, Lazarous, Deepa G., additional, Kassaye, Seble G., additional, Melamed, Michal L., additional, Johns, Tanya S., additional, Mocerino, Ryan, additional, Prudhvi, Kalyan, additional, Zhu, Denzel, additional, Levy, Rebecca V., additional, Azzi, Yorg, additional, Fisher, Molly, additional, Yunes, Milagros, additional, Sedaliu, Kaltrina, additional, Golestaneh, Ladan, additional, Brogan, Maureen, additional, Kumar, Neelja, additional, Chang, Michael, additional, Thakkar, Jyotsana, additional, Raichoudhury, Ritesh, additional, Athreya, Akshay, additional, Farag, Mohamed, additional, Schenck, Edward J., additional, Cho, Soo Jung, additional, Plataki, Maria, additional, Alvarez-Mulett, Sergio L., additional, Gomez-Escobar, Luis G., additional, Pan, Di, additional, Lee, Stefi, additional, Krishnan, Jamuna, additional, Whalen, William, additional, Charytan, David, additional, Macina, Ashley, additional, Chaudhry, Sobaata, additional, Wu, Benjamin, additional, Modersitzki, Frank, additional, Srivastava, Anand, additional, Leidner, Alexander S., additional, Martinez, Carlos, additional, Kruser, Jacqueline M., additional, Wunderink, Richard G., additional, Hodakowski, Alexander J., additional, Velez, Juan Carlos Q., additional, Price-Haywood, Eboni G., additional, Matute-Trochez, Luis A., additional, Hasty, Anna E., additional, Mohamed, Muner M.B., additional, Avasare, Rupali S., additional, Zonies, David, additional, Sise, Meghan E., additional, Newman, Erik T., additional, Omar, Samah Abu, additional, Pokharel, Kapil K., additional, Sharma, Shreyak, additional, Singh, Harkarandeep, additional, Correa, Simon, additional, Shaukat, Tanveer, additional, Kamal, Omer, additional, Wang, Wei, additional, Yang, Heather, additional, Boateng, Jeffery O., additional, Lee, Meghan, additional, Strohbehn, Ian A., additional, Li, Jiahua, additional, Mueller, Ariel L., additional, Redfern, Roberta E., additional, Cairl, Nicholas S., additional, Naimy, Gabriel, additional, Abu-Saif, Abeer, additional, Hall, Danyell, additional, Bickley, Laura, additional, Rowan, Chris, additional, Madhani-Lovely, Farah, additional, Peev, Vasil, additional, Reiser, Jochen, additional, Byun, John J., additional, Vissing, Andrew, additional, Kapania, Esha M., additional, Post, Zoe, additional, Patel, Nilam P., additional, Hermes, Joy-Marie, additional, Sutherland, Anne K., additional, Patrawalla, Amee, additional, Finkel, Diana G., additional, Danek, Barbara A., additional, Arikapudi, Sowminya, additional, Paer, Jeffrey M., additional, Cangialosi, Peter, additional, Liotta, Mark, additional, Radbel, Jared, additional, Puri, Sonika, additional, Sunderram, Jag, additional, Scharf, Matthew T., additional, Ahmed, Ayesha, additional, Berim, Ilya, additional, Vatson, Jayanth S., additional, Anand, Shuchi, additional, Levitt, Joseph E., additional, Garcia, Pablo, additional, Boyle, Suzanne M., additional, Song, Rui, additional, Zhang, Jingjing, additional, Woo, Sang Hoon, additional, Deng, Xiaoying, additional, Katz-Greenberg, Goni, additional, Senter, Katharine, additional, Sharshir, Moh’d A., additional, Rusnak, Vadym V., additional, Ali, Muhammad Imran, additional, Bansal, Anip, additional, Podoll, Amber S., additional, Chonchol, Michel, additional, Sharma, Sunita, additional, Burnham, Ellen L., additional, Rashidi, Arash, additional, Hejal, Rana, additional, Judd, Eric, additional, Latta, Laura, additional, Tolwani, Ashita, additional, Albertson, Timothy E., additional, Adams, Jason Y., additional, Chang, Steven Y., additional, Beutler, Rebecca M., additional, Schulze, Carl E., additional, Macedo, Etienne, additional, Rhee, Harin, additional, Liu, Kathleen D., additional, Jotwani, Vasantha K., additional, Koyner, Jay L., additional, Kunczt, Alissa, additional, Shah, Chintan V., additional, Jaikaransingh, Vishal, additional, Toth-Manikowski, Stephanie M., additional, Joo, Min J., additional, Lash, James P., additional, Neyra, Javier A., additional, Chaaban, Nourhan, additional, Ahmad, Yahya, additional, Elias, Madona, additional, Dy, Rajany, additional, Iardino, Alfredo, additional, Au, Elizabeth H., additional, Sharma, Jill H., additional, Sosa, Marie Anne, additional, Taldone, Sabrina, additional, Contreras, Gabriel, additional, De La Zerda, David, additional, Gershengorn, Hayley B., additional, Hayek, Salim S., additional, Blakely, Pennelope, additional, Berlin, Hanna, additional, Azam, Tariq U., additional, Shadid, Husam, additional, Pan, Michael, additional, Hayer, Patrick O’, additional, Meloche, Chelsea, additional, Feroze, Rafey, additional, Kaakati, Rayan, additional, Perry, Danny, additional, Bitar, Abbas, additional, Anderson, Elizabeth, additional, Padalia, Kishan J., additional, Donnelly, John P., additional, Admon, Andrew J., additional, Flythe, Jennifer E., additional, Tugman, Matthew J., additional, Chang, Emily H., additional, Brown, Brent R., additional, Leonberg-Yoo, Amanda K., additional, Spiardi, Ryan C., additional, Roche, Meaghan S., additional, Vasquez, Charles R., additional, Bansal, Amar D., additional, Ernecoff, Natalie C., additional, Kapoor, Sanjana, additional, Verma, Siddharth, additional, Chen, Huiwen, additional, Kovesdy, Csaba P., additional, Molnar, Miklos Z., additional, Azhar, Ambreen, additional, Hedayati, S. Susan, additional, Nadamuni, Mridula V., additional, Shastri, Shani, additional, Willett, Duwayne L., additional, Short, Samuel A.P., additional, Renaghan, Amanda D., additional, Enfield, Kyle B., additional, Bhatraju, Pavan K., additional, Malik, A. Bilal, additional, Semler, Matthew W., additional, Vijayan, Anitha, additional, Joy, Christina Mariyam, additional, Li, Tingting, additional, Goldberg, Seth, additional, Kao, Patricia F., additional, Schumaker, Greg L., additional, Goyal, Nitender, additional, Faugno, Anthony J., additional, Hsu, Caroline M., additional, Tariq, Asma, additional, Meyer, Leah, additional, Kshirsagar, Ravi K., additional, Weiner, Daniel E., additional, Jose, Aju, additional, Christov, Marta, additional, Griffiths, Jennifer, additional, Gupta, Sanjeev, additional, Kapoor, Aromma, additional, Chugh, Savneek, additional, Wilson, Perry, additional, Arora, Tanima, additional, and Ugwuowo, Ugochukwu, additional

Published
2021
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14. Hospital-Level Variation in Death for Critically Ill Patients with COVID-19

Author

Churpek, Matthew M., primary, Gupta, Shruti, additional, Spicer, Alexandra B., additional, Parker, William F., additional, Fahrenbach, John, additional, Brenner, Samantha K., additional, Leaf, David E., additional, Walther, Carl P., additional, Anumudu, Samaya J., additional, Arunthamakun, Justin, additional, Kopecky, Kathleen F., additional, Milligan, Gregory P., additional, McCullough, Peter A., additional, Nguyen, Thuy-Duyen, additional, Shaefi, Shahzad, additional, Krajewski, Megan L., additional, Shankar, Sidharth, additional, Pannu, Ameeka, additional, Valencia, Juan D., additional, Waikar, Sushrut S., additional, Kibbelaar, Zoe A., additional, Athavale, Ambarish M., additional, Hart, Peter, additional, Upadhyay, Shristi, additional, Vohra, Ishaan, additional, Green, Adam, additional, Rachoin, Jean-Sebastien, additional, Schorr, Christa A., additional, Shea, Lisa, additional, Edmonston, Daniel L., additional, Mosher, Christopher L., additional, Shehata, Alexandre M., additional, Cohen, Zaza, additional, Allusson, Valerie, additional, Bambrick-Santoyo, Gabriela, additional, ul aain Bhatti, Noor, additional, Mehta, Bijal, additional, Williams, Aquino, additional, Walters, Patricia, additional, Go, Ronaldo C., additional, Rose, Keith M., additional, Hernán, Miguel A., additional, Chan, Lili, additional, Mathews, Kusum S., additional, Coca, Steven G., additional, Altman, Deena R., additional, Saha, Aparna, additional, Soh, Howard, additional, Wen, Huei Hsun, additional, Bose, Sonali, additional, Leven, Emily A., additional, Wang, Jing G., additional, Mosoyan, Gohar, additional, Nadkarni, Girish N., additional, Pattharanitima, Pattharawin, additional, Gallagher, Emily J., additional, Friedman, Allon N., additional, Guirguis, John, additional, Kapoor, Rajat, additional, Meshberger, Christopher, additional, Kelly, Katherine J., additional, Parikh, Chirag R., additional, Garibaldi, Brian T., additional, Corona-Villalobos, Celia P., additional, Wen, Yumeng, additional, Menez, Steven, additional, Malik, Rubab F., additional, Cervantes, Elena, additional, Gautam, Samir, additional, Mallappallil, Mary C., additional, Ouyang, Jie, additional, John, Sabu, additional, Yap, Ernie, additional, Melaku, Yohannes, additional, Mohamed, Ibrahim, additional, Bajracharya, Siddartha, additional, Puri, Isha, additional, Thaxton, Mariah, additional, Bhattacharya, Jyotsna, additional, Wagner, John, additional, Boudourakis, Leon, additional, Nguyen, H. Bryant, additional, Ahoubim, Afshin, additional, Thomas, Leslie F., additional, Sirganagari, Dheeraj Reddy, additional, Guru, Pramod K., additional, Kashani, Kianoush, additional, Tehranian, Shahrzad, additional, Zhou, Yan, additional, Bergl, Paul A., additional, Rodriguez, Jesus, additional, Shah, Jatan A., additional, Gupta, Mrigank S., additional, Kumar, Princy N., additional, Lazarous, Deepa G., additional, Kassaye, Seble G., additional, Melamed, Michal L., additional, Johns, Tanya S., additional, Mocerino, Ryan, additional, Prudhvi, Kalyan, additional, Zhu, Denzel, additional, Levy, Rebecca V., additional, Azzi, Yorg, additional, Fisher, Molly, additional, Yunes, Milagros, additional, Sedaliu, Kaltrina, additional, Golestaneh, Ladan, additional, Brogan, Maureen, additional, Kumar, Neelja, additional, Chang, Michael, additional, Thakkar, Jyotsana, additional, Raichoudhury, Ritesh, additional, Athreya, Akshay, additional, Farag, Mohamed, additional, Schenck, Edward J., additional, Cho, Soo Jung, additional, Plataki, Maria, additional, Alvarez-Mulett, Sergio L., additional, Gomez-Escobar, Luis G., additional, Pan, Di, additional, Lee, Stefi, additional, Krishnan, Jamuna, additional, Whalen, William, additional, Charytan, David, additional, Macina, Ashley, additional, Chaudhry, Sobaata, additional, Wu, Benjamin, additional, Modersitzki, Frank, additional, Srivastava, Anand, additional, Leidner, Alexander S., additional, Martinez, Carlos, additional, Kruser, Jacqueline M., additional, Wunderink, Richard G., additional, Hodakowski, Alexander J., additional, Velez, Juan Carlos Q., additional, Price-Haywood, Eboni G., additional, Matute-Trochez, Luis A., additional, Hasty, Anna E., additional, Mohamed, Muner M. B., additional, Avasare, Rupali S., additional, Zonies, David, additional, Sise, Meghan E., additional, Newman, Erik T., additional, Abu Omar, Samah, additional, Pokharel, Kapil K., additional, Sharma, Shreyak, additional, Singh, Harkarandeep, additional, Correa, Simon, additional, Shaukat, Tanveer, additional, Kamal, Omer, additional, Wang, Wei, additional, Yang, Heather, additional, Boateng, Jeffery O., additional, Lee, Meghan, additional, Strohbehn, Ian A., additional, Li, Jiahua, additional, Mueller, Ariel L., additional, Redfern, Roberta, additional, Cairl, Nicholas S., additional, Naimy, Gabriel, additional, Abu-Saif, Abeer, additional, Hall, Danyell, additional, Bickley, Laura, additional, Rowan, Chris, additional, Madhai-Lovely, Farah, additional, Peev, Vasil, additional, Reiser, Jochen, additional, Byun, John J., additional, Vissing, Andrew, additional, Kapania, Esha M., additional, Post, Zoe, additional, Patel, Nilam P., additional, Hermes, Joy-Marie, additional, Sutherland, Anne K., additional, Patrawalla, Amee, additional, Finkel, Diana G., additional, Danek, Barbara A., additional, Arikapudi, Sowminya, additional, Paer, Jeffrey M., additional, Cangialosi, Peter, additional, Liotta, Mark, additional, Radbel, Jared, additional, Sunderram, Jag, additional, Puri, Sonika, additional, Vatson, Jayanth S., additional, Scharf, Matthew T., additional, Ahmed, Ayesha, additional, Berim, Ilya, additional, Anand, Shuchi, additional, Levitt, Joseph E., additional, Garcia, Pablo, additional, Boyle, Suzanne M., additional, Song, Rui, additional, Arif, Ali, additional, Zhang, Jingjing, additional, Woo, Sang Hoon, additional, Deng, Xiaoying, additional, Katz-Greenberg, Goni, additional, Senter, Katharine, additional, Sharshir, Moh’d A., additional, Rusnak, Vadym V., additional, Ali, Muhammad Imran, additional, Peters, Terri, additional, Hughes, Kathy, additional, Bansal, Anip, additional, Podoll, Amber S., additional, Chonchol, Michel, additional, Sharma, Sunita, additional, Burnham, Ellen L., additional, Rashidi, Arash, additional, Hejal, Rana, additional, Judd, Eric, additional, Latta, Laura, additional, Tolwani, Ashita, additional, Albertson, Timothy E., additional, Adams, Jason Y., additional, Chang, Steven Y., additional, Beutler, Rebecca M., additional, Monica, Santa, additional, Schulze, Carl E., additional, Macedo, Etienne, additional, Rhee, Harin, additional, Liu, Kathleen D., additional, Jotwani, Vasantha K., additional, Koyner, Jay L., additional, Shah, Chintan V., additional, Jaikaransingh, Vishal, additional, Toth-Manikowski, Stephanie M., additional, Joo, Min J., additional, Lash, James P., additional, Neyra, Javier A., additional, Chaaban, Nourhan, additional, Iardino, Alfredo, additional, Au, Elizabeth H., additional, Sharma, Jill H., additional, Sosa, Marie Anne, additional, Taldone, Sabrina, additional, Contreras, Gabriel, additional, De La Zerda, David, additional, Fornoni, Alessia, additional, Gershengorn, Hayley B., additional, Hayek, Salim S., additional, Blakely, Pennelope, additional, Berlin, Hanna, additional, Azam, Tariq U., additional, Shadid, Husam, additional, Pan, Michael, additional, O’Hayer, Patrick, additional, Meloche, Chelsea, additional, Feroze, Rafey, additional, Kaakati, Rayan, additional, Perry, Danny, additional, Bitar, Abbas, additional, Anderson, Elizabeth, additional, Padalia, Kishan J., additional, Launius, Christopher, additional, Donnelly, John P., additional, Admon, Andrew J., additional, Flythe, Jennifer E., additional, Tugman, Matthew J., additional, Chang, Emily H., additional, Brown, Brent R., additional, Leonberg-Yoo, Amanda K., additional, Spiardi, Ryan C., additional, Miano, Todd A., additional, Roche, Meaghan S., additional, Vasquez, Charles R., additional, Bansal, Amar D., additional, Ernecoff, Natalie C., additional, Kapoor, Sanjana, additional, Verma, Siddharth, additional, Chen, Huiwen, additional, Kovesdy, Csaba P., additional, Molnar, Miklos Z., additional, Azhar, Ambreen, additional, Hedayati, S. Susan, additional, Nadamuni, Mridula V., additional, Shastri, Shani, additional, Willett, Duwayne L., additional, Short, Samuel A. P., additional, Renaghan, Amanda D., additional, Enfield, Kyle B., additional, Bhatraju, Pavan K., additional, Malik, A. Bilal, additional, Semler, Matthew W., additional, Vijayan, Anitha, additional, Joy, Christina Mariyam, additional, Li, Tingting, additional, Goldberg, Seth, additional, Kao, Patricia F., additional, Schumaker, Greg L., additional, Goyal, Nitender, additional, Faugno, Anthony J., additional, Hsu, Caroline M., additional, Tariq, Asma, additional, Meyer, Leah, additional, Kshirsagar, Ravi K., additional, Weiner, Daniel E., additional, Christov, Marta, additional, Griffiths, Jennifer, additional, Gupta, Sanjeev, additional, Kapoor, Aromma, additional, Wilson, Perry, additional, Arora, Tanima, additional, and Ugwuowo, Ugochukwu, additional

Published
2021
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15. Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19

Author

Gupta, Shruti, Wang, Wei, Hayek, Salim S., Chan, Lili, Mathews, Kusum S., Melamed, Michal L., Brenner, Samantha K., Leonberg-Yoo, Amanda, Schenck, Edward J., Radbel, Jared, Reiser, Jochen, Bansal, Anip, Srivastava, Anand, Zhou, Yan, Finkel, Diana, Green, Adam, Mallappallil, Mary, Faugno, Anthony J., Zhang, Jingjing, Velez, Juan Carlos Q., Shaefi, Shahzad, Parikh, Chirag R., Charytan, David M., Athavale, Ambarish M., Friedman, Allon N., Redfern, Roberta E., Short, Samuel A. P., Correa, Simon, Pokharel, Kapil K., Admon, Andrew J., Donnelly, John P., Gershengorn, Hayley B., Douin, David J., Semler, Matthew W., Hernán, Miguel A., Leaf, David E., Walther, Carl P., Anumudu, Samaya J., Arunthamakun, Justin, Kopecky, Kathleen F., Milligan, Gregory P., McCullough, Peter A., Nguyen, Thuy-Duyen, Krajewski, Megan L., Shankar, Sidharth, Pannu, Ameeka, Valencia, Juan D., Waikar, Sushrut S., Kibbelaar, Zoe A., Hart, Peter, Upadhyay, Shristi, Vohra, Ishaan, Oyintayo, Ajiboye, Rachoin, Jean-Sebastien, Schorr, Christa A., Shea, Lisa, Edmonston, Daniel L., Mosher, Christopher L., Shehata, Alexandre M., Cohen, Zaza, Allusson, Valerie, Bambrick-Santoyo, Gabriela, Bhatti, Noor ul aain, Mehta, Bijal, Williams, Aquino, Walters, Patricia, Go, Ronaldo C., Rose, Keith M., Lisk, Rebecca, Zhou, Amy M., Kim, Ethan C., Coca, Steven G., Altman, Deena R., Saha, Aparna, Soh, Howard, Wen, Huei Hsun, Bose, Sonali, Leven, Emily A., Wang, Jing G., Mosoyan, Gohar, Nadkarni, Girish N., Pattharanitima, Pattharawin, Gallagher, Emily J., Guirguis, John, Kapoor, Rajat, Meshberger, Christopher, Kelly, Katherine J., Garibaldi, Brian T., Corona-Villalobos, Celia P., Wen, Yumeng, Menez, Steven, Malik, Rubab F., Cervantes, Carmen Elena, Gautam, Samir C., Mallappallil, Mary C., Ouyang, Jie, John, Sabu, Yap, Ernie, Melaku, Yohannes, Mohamed, Ibrahim, Bajracharya, Siddhartha, Puri, Isha, Thaxton, Mariah, Bhattacharya, Jyotsna, Wagner, John, Boudourakis, Leon, Nguyen, H. Bryant, Ahoubim, Afshin, Kashani, Kianoush, Tehranian, Shahrzad, Thomas, Leslie F., Sirganagari, Dheeraj Reddy, Guru, Pramod K., Bergl, Paul A., Rodriguez, Jesus, Shah, Jatan A., Gupta, Mrigank S., Kumar, Princy N., Lazarous, Deepa G., Kassaye, Seble G., Johns, Tanya S., Mocerino, Ryan, Prudhvi, Kalyan, Zhu, Denzel, Levy, Rebecca V., Azzi, Yorg, Fisher, Molly, Yunes, Milagros, Sedaliu, Kaltrina, Golestaneh, Ladan, Brogan, Maureen, Kumar, Neelja, Chang, Michael, Thakkar, Jyotsana, Raichoudhury, Ritesh, Athreya, Akshay, Farag, Mohamed, Cho, Soo Jung, Plataki, Maria, Alvarez-Mulett, Sergio L., Gomez-Escobar, Luis G., Pan, Di, Lee, Stefi, Krishnan, Jamuna, Whalen, William, Charytan, David, Macina, Ashley, Chaudhry, Sobaata, Wu, Benjamin, Modersitzki, Frank, Leidner, Alexander S., Martinez, Carlos, Kruser, Jacqueline M., Wunderink, Richard G., Hodakowski, Alexander J., Price-Haywood, Eboni G., Matute-Trochez, Luis A., Hasty, Anna E., Mohamed, Muner MB., Avasare, Rupali S., Zonies, David, Sise, Meghan E., Newman, Erik T., Omar, Samah Abu, Sharma, Shreyak, Singh, Harkarandeep, Shaukat, Tanveer, Kamal, Omer, Yang, Heather, Boateng, Jeffery O., Lee, Meghan, Strohbehn, Ian A., Li, Jiahua, Mueller, Ariel L., Cairl, Nicholas S., Naimy, Gabriel, Abu-Saif, Abeer, Hall, Danyell, Bickley, Laura, Rowan, Chris, Madhani-Lovely, Farah, Peev, Vasil, Byun, John J., Vissing, Andrew, Kapania, Esha M., Post, Zoe, Patel, Nilam P., Hermes, Joy-Marie, Sutherland, Anne K., Patrawalla, Amee, Finkel, Diana G., Danek, Barbara A., Arikapudi, Sowminya, Paer, Jeffrey M., Cangialosi, Peter, Liotta, Mark, Puri, Sonika, Sunderram, Jag, Scharf, Matthew T., Ahmed, Ayesha, Berim, Ilya, Vatson, Jayanth S., Anand, Shuchi, Levitt, Joseph E., Garcia, Pablo, Boyle, Suzanne M., Song, Rui, Arif, Ali, Woo, Sang Hoon, Deng, Xiaoying, Katz-Greenberg, Goni, Senter, Katharine, Sharshir, Moh’d A., Rusnak, Vadym V., Ali, Muhammad Imran, Peters, Terri, Hughes, Kathy, Podoll, Amber S., Chonchol, Michel, Sharma, Sunita, Burnham, Ellen L., Rashidi, Arash, Hejal, Rana, Judd, Eric, Latta, Laura, Tolwani, Ashita, Albertson, Timothy E., Adams, Jason Y., Chang, Steven Y., Beutler, Rebecca M., Schulze, Carl E., Macedo, Etienne, Rhee, Harin, Liu, Kathleen D., Jotwani, Vasantha K., Koyner, Jay L., Shah, Chintan V., Jaikaransingh, Vishal, Toth-Manikowski, Stephanie M., Joo, Min J., Lash, James P., Neyra, Javier A., Chaaban, Nourhan, Elias, Madona, Ahmad, Yahya, Iardino, Alfredo, Au, Elizabeth H., Sharma, Jill H., Sosa, Marie Anne, Taldone, Sabrina, Contreras, Gabriel, Zerda, David De La, Fornoni, Alessia, Blakely, Pennelope, Berlin, Hanna, Azam, Tariq U., Shadid, Husam, Pan, Michael, O’ Hayer, Patrick, Meloche, Chelsea, Feroze, Rafey, Padalia, Kishan J., Bitar, Abbas, Leya, Jeff, Flythe, Jennifer E., Tugman, Matthew J., Chang, Emily H., Brown, Brent R., Leonberg-Yoo, Amanda K., Spiardi, Ryan C., Miano, Todd A., Roche, Meaghan S., Vasquez, Charles R., Bansal, Amar D., Ernecoff, Natalie C., Kapoor, Sanjana, Verma, Siddharth, Chen, Huiwen, Kovesdy, Csaba P., Molnar, Miklos Z., Azhar, Ambreen, Hedayati, S. Susan, Nadamuni, Mridula V., Shastri, Shani, Willett, Duwayne L., Short, Samuel A.P., Renaghan, Amanda D., Enfield, Kyle B., Bhatraju, Pavan K., Malik, A. Bilal, Vijayan, Anitha, Joy, Christina Mariyam, Li, Tingting, Goldberg, Seth, Kao, Patricia F., Schumaker, Greg L., Goyal, Nitender, Hsu, Caroline M., Tariq, Asma, Meyer, Leah, Kshirsagar, Ravi K., Jose, Aju, Weiner, Daniel E., Christov, Marta, Griffiths, Jennifer, Gupta, Sanjeev, Kapoor, Aromma, Wilson, Perry, Arora, Tanima, and Ugwuowo, Ugochukwu

Subjects
musculoskeletal diseases, medicine.medical_specialty, Population, 01 natural sciences, law.invention, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Tocilizumab, Interquartile range, law, Intensive care, Internal medicine, Fraction of inspired oxygen, medicine, Internal Medicine, 030212 general & internal medicine, 0101 mathematics, education, Original Investigation, education.field_of_study, business.industry, 010102 general mathematics, Hazard ratio, Intensive care unit, chemistry, business, Cohort study
Abstract

IMPORTANCE: Therapies that improve survival in critically ill patients with coronavirus disease 2019 (COVID-19) are needed. Tocilizumab, a monoclonal antibody against the interleukin 6 receptor, may counteract the inflammatory cytokine release syndrome in patients with severe COVID-19 illness. OBJECTIVE: To test whether tocilizumab decreases mortality in this population. DESIGN, SETTING, AND PARTICIPANTS: The data for this study were derived from a multicenter cohort study of 4485 adults with COVID-19 admitted to participating intensive care units (ICUs) at 68 hospitals across the US from March 4 to May 10, 2020. Critically ill adults with COVID-19 were categorized according to whether they received or did not receive tocilizumab in the first 2 days of admission to the ICU. Data were collected retrospectively until June 12, 2020. A Cox regression model with inverse probability weighting was used to adjust for confounding. EXPOSURES: Treatment with tocilizumab in the first 2 days of ICU admission. MAIN OUTCOMES AND MEASURES: Time to death, compared via hazard ratios (HRs), and 30-day mortality, compared via risk differences. RESULTS: Among the 3924 patients included in the analysis (2464 male [62.8%]; median age, 62 [interquartile range {IQR}, 52-71] years), 433 (11.0%) received tocilizumab in the first 2 days of ICU admission. Patients treated with tocilizumab were younger (median age, 58 [IQR, 48-65] vs 63 [IQR, 52-72] years) and had a higher prevalence of hypoxemia on ICU admission (205 of 433 [47.3%] vs 1322 of 3491 [37.9%] with mechanical ventilation and a ratio of partial pressure of arterial oxygen to fraction of inspired oxygen of

Published
2021
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16. Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19

Author

Al-Samkari, Hanny, primary, Gupta, Shruti, additional, Leaf, Rebecca Karp, additional, Wang, Wei, additional, Rosovsky, Rachel P., additional, Brenner, Samantha K., additional, Hayek, Salim S., additional, Berlin, Hanna, additional, Kapoor, Rajat, additional, Shaefi, Shahzad, additional, Melamed, Michal L., additional, Sutherland, Anne, additional, Radbel, Jared, additional, Green, Adam, additional, Garibaldi, Brian T., additional, Srivastava, Anand, additional, Leonberg-Yoo, Amanda, additional, Shehata, Alexandre M., additional, Flythe, Jennifer E., additional, Rashidi, Arash, additional, Goyal, Nitender, additional, Chan, Lili, additional, Mathews, Kusum S., additional, Hedayati, S. Susan, additional, Dy, Rajany, additional, Toth-Manikowski, Stephanie M., additional, Zhang, Jingjing, additional, Mallappallil, Mary, additional, Redfern, Roberta E., additional, Bansal, Amar D., additional, Short, Samuel A.P., additional, Vangel, Mark G., additional, Admon, Andrew J., additional, Semler, Matthew W., additional, Bauer, Kenneth A., additional, Hernán, Miguel A., additional, Leaf, David E., additional, Walther, Carl P., additional, Anumudu, Samaya J., additional, Arunthamakun, Justin, additional, Kopecky, Kathleen F., additional, Milligan, Gregory P., additional, McCullough, Peter A., additional, Nguyen, Thuy-Duyen, additional, Krajewski, Megan L., additional, Shankar, Sidharth, additional, Pannu, Ameeka, additional, Valencia, Juan D., additional, Waikar, Sushrut S., additional, Kibbelaar, Zoe A., additional, Athavale, Ambarish M., additional, Hart, Peter, additional, Upadhyay, Shristi, additional, Vohra, Ishaan, additional, Oyintayo, Ajiboye, additional, Rachoin, Jean-Sebastien, additional, Schorr, Christa A., additional, Shea, Lisa, additional, Edmonston, Daniel L., additional, Mosher, Christopher L., additional, Cohen, Zaza, additional, Allusson, Valerie, additional, Bambrick-Santoyo, Gabriela, additional, aain Bhatti, Noor ul, additional, Mehta, Bijal, additional, Williams, Aquino, additional, Walters, Patricia, additional, Go, Ronaldo C., additional, Rose, Keith M., additional, Zhou, Amy M., additional, Kim, Ethan C., additional, Lisk, Rebecca, additional, Coca, Steven G., additional, Altman, Deena R., additional, Saha, Aparna, additional, Soh, Howard, additional, Wen, Huei Hsun, additional, Bose, Sonali, additional, Leven, Emily A., additional, Wang, Jing G., additional, Mosoyan, Gohar, additional, Pattharanitima, Pattharawin, additional, Gallagher, Emily J., additional, Friedman, Allon N., additional, Guirguis, John, additional, Meshberger, Christopher, additional, Kelly, Katherine J., additional, Parikh, Chirag R., additional, Corona-Villalobos, Celia P., additional, Wen, Yumeng, additional, Menez, Steven, additional, Malik, Rubab F., additional, Cervantes, Carmen Elena, additional, Gautam, Samir C., additional, Mallappallil, Mary C., additional, Ouyang, Jie, additional, John, Sabu, additional, Yap, Ernie, additional, Melaku, Yohannes, additional, Mohamed, Ibrahim, additional, Bajracharya, Siddhartha, additional, Puri, Isha, additional, Thaxton, Mariah, additional, Bhattacharya, Jyotsna, additional, Wagner, John, additional, Boudourakis, Leon, additional, Nguyen, H. Bryant, additional, Ahoubim, Afshin, additional, Thomas, Leslie F., additional, Sirganagari, Dheeraj Reddy, additional, Guru, Pramod K., additional, Zhou, Yan, additional, Bergl, Paul A., additional, Rodriguez, Jesus, additional, Shah, Jatan A., additional, Gupta, Mrigank S., additional, Kumar, Princy N., additional, Lazarous, Deepa G., additional, Kassaye, Seble G., additional, Johns, Tanya S., additional, Mocerino, Ryan, additional, Prudhvi, Kalyan, additional, Zhu, Denzel, additional, Levy, Rebecca V., additional, Azzi, Yorg, additional, Fisher, Molly, additional, Yunes, Milagros, additional, Sedaliu, Kaltrina, additional, Golestaneh, Ladan, additional, Brogan, Maureen, additional, Thakkar, Jyotsana, additional, Kumar, Neelja, additional, Ross, Michael J., additional, Chang, Michael, additional, Raichoudhury, Ritesh, additional, Athreya, Akshay, additional, Farag, Mohamed, additional, Schenck, Edward J., additional, Cho, Soo Jung, additional, Plataki, Maria, additional, Alvarez-Mulett, Sergio L., additional, Gomez-Escobar, Luis G., additional, Pan, Di, additional, Lee, Stefi, additional, Krishnan, Jamuna, additional, Whalen, William, additional, Charytan, David, additional, Macina, Ashley, additional, Leidner, Alexander S., additional, Martinez, Carlos, additional, Kruser, Jacqueline M., additional, Wunderink, Richard G., additional, Hodakowski, Alexander J., additional, Q. Velez, Juan Carlos, additional, Price-Haywood, Eboni G., additional, Matute-Trochez, Luis A., additional, Hasty, Anna E., additional, Mohamed, Muner M.B., additional, Avasare, Rupali S., additional, Zonies, David, additional, Al-Samkari, Hanny, additional, Rosovsky, Rachel, additional, Sise, Meghan E., additional, Newman, Erik T., additional, Omar, Samah Abu, additional, Pokharel, Kapil K., additional, Sharma, Shreyak, additional, Singh, Harkarandeep, additional, Correa, Simon, additional, Shaukat, Tanveer, additional, Kamal, Omer, additional, Lee, Meghan, additional, Strohbehn, Ian A., additional, Li, Jiahua, additional, Mueller, Ariel L., additional, Cairl, Nicholas S., additional, Naimy, Gabriel, additional, Abu-Saif, Abeer, additional, Hall, Danyell, additional, Bickley, Laura, additional, Rowan, Chris, additional, Madhani-Lovely, Farah, additional, Peev, Vasil, additional, Reiser, Jochen, additional, Byun, John J., additional, Vissing, Andrew, additional, Kapania, Esha M., additional, Post, Zoe, additional, Patel, Nilam P., additional, Hermes, Joy-Marie, additional, Sutherland, Anne K., additional, Patrawalla, Amee, additional, Finkel, Diana G., additional, Danek, Barbara A., additional, Arikapudi, Sowminya, additional, Paer, Jeffrey M., additional, Cangialosi, Peter, additional, Liotta, Mark, additional, Puri, Sonika, additional, Sunderram, Jag, additional, Scharf, Matthew T., additional, Ahmed, Ayesha, additional, Berim, Ilya, additional, Vatson, Jayanth S., additional, Karp, George, additional, Anand, Shuchi, additional, Levitt, Joseph E., additional, Garcia, Pablo, additional, Boyle, Suzanne M., additional, Song, Rui, additional, Woo, Sang Hoon, additional, Deng, Xiaoying, additional, Katz-Greenberg, Goni, additional, Sharshir, Moh'd A., additional, Rusnak, Vadym V., additional, Ali, Muhammad Imran, additional, Bansal, Anip, additional, Podoll, Amber S., additional, Chonchol, Michel, additional, Sharma, Sunita, additional, Burnham, Ellen L., additional, Hejal, Rana, additional, Judd, Eric, additional, Latta, Laura, additional, Tolwani, Ashita, additional, Albertson, Timothy E., additional, Adams, Jason Y., additional, Chang, Steven Y., additional, Beutler, Rebecca M., additional, Schulze, Carl E., additional, Macedo, Etienne, additional, Rhee, Harin, additional, Liu, Kathleen D., additional, Jotwani, Vasantha K., additional, Koyner, Jay L., additional, Shah, Chintan V., additional, Jaikaransingh, Vishal, additional, Joo, Min J., additional, Lash, James P., additional, Neyra, Javier A., additional, Chaaban, Nourhan, additional, Elias, Madona, additional, Ahmad, Yahya, additional, Iardino, Alfredo, additional, Au, Elizabeth H., additional, Sharma, Jill H., additional, Sosa, Marie Anne, additional, Taldone, Sabrina, additional, Contreras, Gabriel, additional, De La Zerda, David, additional, Gershengorn, Hayley B., additional, Fornoni, Alessia, additional, Blakely, Pennelope, additional, Azam, Tariq U., additional, Shadid, Husam, additional, Pan, Michael, additional, O’Hayer, Patrick, additional, Meloche, Chelsea, additional, Feroze, Rafey, additional, Padalia, Kishan J., additional, Leya, Jeff, additional, Donnelly, John P., additional, Tugman, Matthew J., additional, Chang, Emily H., additional, Brown, Brent R., additional, Leonberg-Yoo, Amanda K., additional, Spiardi, Ryan C., additional, Miano, Todd A., additional, Roche, Meaghan S., additional, Vasquez, Charles R., additional, Ernecoff, Natalie C., additional, Kapoor, Sanjana, additional, Verma, Siddharth, additional, Chen, Huiwen, additional, Kovesdy, Csaba P., additional, Molnar, Miklos Z., additional, Azhar, Ambreen, additional, Nadamuni, Mridula V., additional, Shastri, Shani, additional, Willett, Duwayne L., additional, Renaghan, Amanda D., additional, Enfield, Kyle B., additional, Bhatraju, Pavan K., additional, Malik, A. Bilal, additional, Vijayan, Anitha, additional, Joy, Christina Mariyam, additional, Li, Tingting, additional, Goldberg, Seth, additional, Kao, Patricia F., additional, Schumaker, Greg L., additional, Faugno, Anthony J., additional, Hsu, Caroline M., additional, Tariq, Asma, additional, Meyer, Leah, additional, Kshirsagar, Ravi K., additional, Weiner, Daniel E., additional, Christov, Marta, additional, Griffiths, Jennifer, additional, Gupta, Sanjeev, additional, Kapoor, Aromma, additional, Chugh, Savneek, additional, Wilson, Perry, additional, Arora, Tanima, additional, and Ugwuowo, Ugochukwu, additional

Published
2021
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19. Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US

Author

Gupta, Shruti, Hayek, Salim S., Wang, Wei, Chan, Lili, Mathews, Kusum S., Melamed, Michal L., Brenner, Samantha K., Leonberg-Yoo, Amanda, Schenck, Edward J., Radbel, Jared, Reiser, Jochen, Bansal, Anip, Srivastava, Anand, Zhou, Yan, Sutherland, Anne, Green, Adam, Shehata, Alexandre M., Goyal, Nitender, Vijayan, Anitha, Velez, Juan Carlos Q., Shaefi, Shahzad, Parikh, Chirag R., Arunthamakun, Justin, Athavale, Ambarish M., Friedman, Allon N., Short, Samuel A. P., Kibbelaar, Zoe A., Abu Omar, Samah, Admon, Andrew J., Donnelly, John P., Gershengorn, Hayley B., Hernán, Miguel A., Semler, Matthew W., Leaf, David E., Walther, Carl P, Anumudu, Samaya J, Kopecky, Kathleen F, Milligan, Gregory P, McCullough, Peter A, Nguyen, Thuy-Duyen, Krajewski, Megan L, Shankar, Sidharth, Pannu, Ameeka, Valencia, Juan D, Waikar, Sushrut S, Hart, Peter, Ajiboye, Oyintayo, Itteera, Matthew, Rachoin, Jean-Sebastien, Schorr, Christa A, Shea, Lisa, Edmonston, Daniel L, Mosher, Christopher L, Karp, Aaron, Cohen, Zaza, Allusson, Valerie, Bambrick-Santoyo, Gabriela, Bhatti, Noor ul aain, Mehta, Bijal, Williams, Aquino, Walters, Patricia, Go, Rolando C, Rose, Keith M, Zhou, Amy M, Kim, Ethan C, Lisk, Rebecca, Coca, Steven G, Altman, Deena R, Saha, Aparna, Soh, Howard, Wen, Huei Hsun, Bose, Sonali, Leven, Emily A, Wang, Jing G, Mosoyan, Gohar, Nadkarni, Girish N, Guirguis, John, Kapoor, Rajat, Meshberger, Christopher, Garibaldi, Brian T, Corona-Villalobos, Celia P, Wen, Yumeng, Menez, Steven, Malik, Rubab F, Cervantes, Carmen Elena, Gautam, Samir C, Nguyen, H Byrant, Ahoubim, Afshin, Thomas, Leslie F, Sirganagari, Dheeraj Reddy, Guru, Pramod K, Bergl, Paul A, Rodriguez, Jesus, Shah, Jatan A, Gupta, Mrigank S, Kumar, Princy N, Lazarous, Deepa G, Kassaye, Seble G, Johns, Tanya S, Mocerino, Ryan, Prudhvi, Kalyan, Zhu, Denzel, Levy, Rebecca V, Azzi, Yorg, Fisher, Molly, Yunes, Milagros, Sedaliu, Kaltrina, Golestaneh, Ladan, Brogan, Maureen, Raichoudhury, Ritesh, Cho, Soo Jung, Plataki, Maria, Alvarez-Mulett, Sergio L, Gomez-Escobar, Luis G, Pan, Di, Lee, Stefi, Kirshnan, Jamuna, Whalen, William, Charytan, David, Macina, Ashley, Ross, Daniel W, Leidner, Alexander S, Martinez, Carlos, Kruser, Jacqueline M, Wunderink, Richard G, Hodakowski, Alexander J, Price-Haywood, Eboni G, Matute-Trochez, Luis A, Hasty, Anne E, Mohamed, Muner MB, Avasare, Rupali S, Zonies, David, Baron, Rebecca M, Sise, Meghan E, Newman, Erik T, Pokharel, Kapil K, Sharma, Shreyak, Singh, Harkarandeep, Correa, Simon, Shaukat, Tanveer, Kamal, Omer, Yang, Heather, Boateng, Jeffery O, Lee, Meghan, Strohbehn, Ian A, Li, Jiahua, Muhsin, Saif A, Mandel, Ernest I, Mueller, Ariel L, Cairl, Nicholas S, Rowan, Chris, Madhai-Lovely, Farah, Peev, Vasil, Byun, John J, Vissing, Andrew, Kapania, Esha M, Post, Zoe, Patel, Nilam P, Hermes, Joy-Marie, Patrawalla, Amee, Finkel, Diana G, Danek, Barbara A, Arikapudi, Sowminya, Paer, Jeffery M, Puri, Sonika, Sunderram, Jag, Scharf, Matthew T, Ahmed, Ayesha, Berim, Ilya, Hussain, Sabiha, Anand, Shuchi, Levitt, Joseph E, Garcia, Pablo, Boyle, Suzanne M, Song, Rui, Zhang, Jingjing, Sharshir, Mohd A, Rusnak, Vadym V, Podoll, Amber S, Chonchol, Michel, Sharma, Sunita, Burnham, Ellen L, Rashidi, Arash, Hejal, Rana, Judd, Erik T, Latta, Laura, Tolwani, Ashita, Albertson, Timothy E, Adams, Jason Y, Chang, Steven Y, Beutler, Rebecca M, Schulze, Carl E, Macedo, Etienne, Rhee, Harin, Liu, Kathleen D, Jotwani, Vasantha K, Koyner, Jay L, Shah, Chintan V, Jaikaransingh, Vishal, Toth-Manikowski, Stephanie M, Joo, Min J, Lash, James P, Neyra, Javier A, Chaaban, Nourhan, Iardino, Alfredo, Au, Elizabeth H, Sharma, Jill H, Sosa, Marie Anne, Taldone, Sabrina, Contreras, Gabriel, Zerda, David De La, Blakely, Pennelope, Berlin, Hanna, Azam, Tariq U, Shadid, Husam, Pan, Michael, OHayer, Patrick, Meloche, Chelsea, Feroze, Rafey, Padalia, Kishan J, Bitar, Abbas, Flythe, Jennifer E, Tugman, Matthew J, Brown, Brent R, Spiardi, Ryan C, Miano, Todd A, Roche, Meaghan S, Vasquez, Charles R, Bansal, Amar D, Ernecoff, Natalie C, Kovesdy, Csaba P, Molnar, Miklos Z, Azhar, Ambreen, Hedayati, Susan S, Nadamuni, Mridula V, Khan, Sadaf S, Willett, Duwayne L, Renaghan, Amanda D, Bhatraju, Pavan K, Malik, Bilal A, Joy, Christina Mariyam, Li, Tingting, Goldberg, Seth, Kao, Patricia F, Schumaker, Greg L, Faugno, Anthony J, Hsu, Caroline M, Tariq, Asma, Meyer, Leah, Weiner, Daniel E, Christov, Marta, Wilson, Francis P, Arora, Tanima, and Ugwuowo, Ugochukwu

Subjects
medicine.medical_specialty, business.industry, 010102 general mathematics, Organ dysfunction, Odds ratio, medicine.disease, 01 natural sciences, Intensive care unit, Comorbidity, law.invention, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, law, Intensive care, Internal medicine, Internal Medicine, Medicine, 030212 general & internal medicine, 0101 mathematics, medicine.symptom, business, Body mass index, Cohort study
Abstract

Importance: The US is currently an epicenter of the coronavirus disease 2019 (COVID-19) pandemic, yet few national data are available on patient characteristics, treatment, and outcomes of critical illness from COVID-19. Objectives: To assess factors associated with death and to examine interhospital variation in treatment and outcomes for patients with COVID-19. Design, Setting, and Participants: This multicenter cohort study assessed 2215 adults with laboratory-confirmed COVID-19 who were admitted to intensive care units (ICUs) at 65 hospitals across the US from March 4 to April 4, 2020. Exposures: Patient-level data, including demographics, comorbidities, and organ dysfunction, and hospital characteristics, including number of ICU beds. Main Outcomes and Measures: The primary outcome was 28-day in-hospital mortality. Multilevel logistic regression was used to evaluate factors associated with death and to examine interhospital variation in treatment and outcomes. Results: A total of 2215 patients (mean [SD] age, 60.5 [14.5] years; 1436 [64.8%] male; 1738 [78.5%] with at least 1 chronic comorbidity) were included in the study. At 28 days after ICU admission, 784 patients (35.4%) had died, 824 (37.2%) were discharged, and 607 (27.4%) remained hospitalized. At the end of study follow-up (median, 16 days; interquartile range, 8-28 days), 875 patients (39.5%) had died, 1203 (54.3%) were discharged, and 137 (6.2%) remained hospitalized. Factors independently associated with death included older age (≥80 vs

Published
2020

20. In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study

Author

Hayek, Salim S, Brenner, Samantha K, Azam, Tariq U, Shadid, Husam R, Anderson, Elizabeth, Berlin, Hanna, Pan, Michael, Meloche, Chelsea, Feroz, Rafey, O’Hayer, Patrick, Kaakati, Rayan, Bitar, Abbas, Padalia, Kishan, Perry, Daniel, Blakely, Pennelope, Gupta, Shruti, Shaefi, Shahzad, Srivastava, Anand, Charytan, David M, Bansal, Anip, Mallappallil, Mary, Melamed, Michal L, Shehata, Alexandre M, Sunderram, Jag, Mathews, Kusum S, Sutherland, Anne K, Nallamothu, Brahmajee K, Leaf, David E, Malik, A Bilal, Abu-Saif, Abeer, Green, Adam, Ahoubim, Afshin, Oyintayo, Ajiboye, Jose, Aju, Athreya, Akshay, Jacobs, Alanna L, Fornoni, Alessia, Hodakowski, Alexander J, Leidner, Alexander S, Iardino, Alfredo, Friedman, Allon N, Renaghan, Amanda D, Leonberg-Yoo, Amanda K, Bansal, Amar D, Athavale, Ambarish M, Podoll, Amber S, Azhar, Ambreen, Patrawalla, Amee, Pannu, Ameeka, Zhou, Amy M, Admon, Andrew J, Vissing, Andrew, Vijayan, Anitha, Hasty, Anna E, Faugno, Anthony J, Saha, Aparna, Williams, Aquino, Rashidi, Arash, Mueller, Ariel L, Kapoor, Aromma, Tolwani, Ashita, Macina, Ashley, Tariq, Asma, Ahmed, Ayesha, Danek, Barbara A, Wu, Benjamin, Shukla, Bhavarth, Mehta, Bijal, Brown, Brent R, Garibaldi, Brian T, Schulze, Carl E, Walther, Carl P, Martinez, Carlos, Hsu, Caroline M, Corona-Villalobos, Celia P, Vasquez, Charles R, Shah, Chintan V, Parikh, Chirag R, Rowan, Chris, Schorr, Christa A, Joy, Christina Mariyam, Mosher, Christopher L, Meshberger, Christopher, Kovesdy, Csaba P, Weiner, Daniel E, Edmonston, Daniel L, Perry, Danny, Hall, Danyell, Charytan, David, De La Zerda, David, Zonies, David, Altman, Deena R, Lazarous, Deepa G, Zhu, Denzel, Sirganagari, Dheeraj Reddy, Pan, Di, Finkel, Diana G, Willett, Duwayne L, Price-Haywood, Eboni G, Schenck, Edward J, Cervantes, Carmen Elena, Au, Elizabeth H, Burnham, Ellen L, Leven, Emily A, Chang, Emily H, Gallagher, Emily J, Judd, Eric, Newman, Erik T, Yap, Ernie, Kapania, Esha M, Kim, Ethan C, Macedo, Etienne, Madhani-Lovely, Farah, Modersitzki, Frank, Contreras, Gabriel, Naimy, Gabriel, Bambrick-Santoyo, Gabriela, Nadkarni, Girish N, Mosoyan, Gohar, Katz-Greenberg, Goni, Schumaker, Greg L, Milligan, Gregory P, Nguyen, H Bryant, Rhee, Harin, Singh, Harkarandeep, Gershengorn, Hayley B, Yang, Heather, Soh, Howard, Wen, Huei Hsun, Chen, Huiwen, Shadid, Husam, Strohbehn, Ian A, Mohamed, Ibrahim, Berim, Ilya, Puri, Isha, Vohra, Ishaan, Kruser, Jacqueline M, Lash, James P, Krishnan, Jamuna, Radbel, Jared, Adams, Jason Y, Shah, Jatan A, Neyra, Javier A, Koyner, Jay L, Vatson, Jayanth S, Rachoin, Jean-Sebastien, Boateng, Jeffery O, Paer, Jeffrey M, Flythe, Jennifer E, Griffiths, Jennifer, Rodriguez, Jesus, Li, Jiahua, Ouyang, Jie, Sharma, Jill H, Wang, Jing G, Zhang, Jingjing, Reiser, Jochen, Guirguis, John, Byun, John J, Donnelly, John P, Wagner, John, Levitt, Joseph E, Hermes, Joy-Marie, Velez, Juan Carlos Q, Valencia, Juan D, Arunthamakun, Justin, Thakkar, Jyotsana, Bhattacharya, Jyotsna, Sedaliu, Kaltrina, Prudhvi, Kalyan, Pokharel, Kapil K, Senter, Katharine, Kelly, Katherine J, Liu, Kathleen D, Kopecky, Kathleen F, Rose, Keith M, Kashani, Kianoush, Padalia, Kishan J, Hess, Kristen M, Enfield, Kyle B, Golestaneh, Ladan, Bickley, Laura, Latta, Laura, Meyer, Leah, Boudourakis, Leon, Thomas, Leslie F, Chan, Lili, Shea, Lisa, Matute-Trochez, Luis A, Gomez-Escobar, Luis G, Elias, Madona, Plataki, Maria, Thaxton, Mariah, Sosa, Marie Anne, Liotta, Mark, Christov, Marta, Mallappallil, Mary C, Tugman, Matthew J, Scharf, Matthew T, Semler, Matthew W, Brogan, Maureen, Roche, Meaghan S, Krajewski, Megan L, Sise, Meghan E, Lee, Meghan, Chang, Michael, Chonchol, Michel, Hernán, Miguel A, Molnar, Miklos Z, Yunes, Milagros, Joo, Min J, Sharshir, Moh’d A, Farag, Mohamed, Fisher, Molly, Nadamuni, Mridula V, Gupta, Mrigank S, Ali, Muhammad Imran, Mohamed, Muner MB, Ernecoff, Natalie C, Kumar, Neelja, Cairl, Nicholas S, Patel, Nilam P, Goyal, Nitender, ul aain Bhatti, Noor, Chaaban, Nourhan, Kamal, Omer, Garcia, Pablo, Kao, Patricia F, Walters, Patricia, O’ Hayer, Patrick, Pattharanitima, Pattharawin, Bergl, Paul A, Bhatraju, Pavan K, Wilson, Perry, McCullough, Peter A, Cangialosi, Peter, Hart, Peter, Guru, Pramod K, Kumar, Princy N, Feroze, Rafey, Kapoor, Rajat, Hejal, Rana, Kshirsagar, Ravi K, Lisk, Rebecca, Beutler, Rebecca M, Levy, Rebecca V, Wunderink, Richard G, Raichoudhury, Ritesh, Redfern, Roberta E, Go, Ronaldo C, Malik, Rubab F, Song, Rui, Avasare, Rupali S, Mocerino, Ryan, Spiardi, Ryan C, Hedayati, S Susan, Taldone, Sabrina, John, Sabu, Abu Omar, Samah, Anumudu, Samaya J, Gautam, Samir C, Short, Samuel AP, Woo, Sang Hoon, Kapoor, Sanjana, Gupta, Sanjeev, Kassaye, Seble G, Alvarez-Mulett, Sergio L, Goldberg, Seth, Tehranian, Shahrzad, Shastri, Shani, Sharma, Shreyak, Upadhyay, Shristi, Anand, Shuchi, Bajracharya, Siddhartha, Verma, Siddharth, Shankar, Sidharth, Correa, Simon, Chaudhry, Sobaata, Bose, Sonali, Puri, Sonika, Cho, Soo Jung, Arikapudi, Sowminya, Lee, Stefi, Toth-Manikowski, Stephanie M, Coca, Steven G, Menez, Steven, Chang, Steven Y, Sharma, Sunita, Waikar, Sushrut S, Boyle, Suzanne M, Arora, Tanima, Ferreira, Tanira, Shaukat, Tanveer, Johns, Tanya S, Nguyen, Thuy-Duyen, Albertson, Timothy E, Li, Tingting, Miano, Todd A, Ugwuowo, Ugochukwu, Rusnak, Vadym V, Allusson, Valerie, Jotwani, Vasantha K, Peev, Vasil, Jaikaransingh, Vishal, Cruz, Vivian S, Wang, Wei, Whalen, William, Deng, Xiaoying, Ahmad, Yahya, Zhou, Yan, Melaku, Yohannes, Azzi, Yorg, Wen, Yumeng, Cohen, Zaza, Kibbelaar, Zoe A, and Post, Zoe

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Pneumonia, Viral, 030204 cardiovascular system & hematology, law.invention, Cohort Studies, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, law, Intensive care, Humans, Medicine, Hospital Mortality, Cardiopulmonary resuscitation, Asystole, Pandemics, Aged, Aged, 80 and over, SARS-CoV-2, business.industry, Research, Incidence (epidemiology), COVID-19, 030208 emergency & critical care medicine, General Medicine, Middle Aged, medicine.disease, Intensive care unit, United States, Heart Arrest, Intensive Care Units, Pneumonia, Pulseless electrical activity, Emergency medicine, Female, Coronavirus Infections, business, Cohort study
Abstract

Objectives To estimate the incidence, risk factors, and outcomes associated with in-hospital cardiac arrest and cardiopulmonary resuscitation in critically ill adults with coronavirus disease 2019 (covid-19). Design Multicenter cohort study. Setting Intensive care units at 68 geographically diverse hospitals across the United States. Participants Critically ill adults (age ≥18 years) with laboratory confirmed covid-19. Main outcome measures In-hospital cardiac arrest within 14 days of admission to an intensive care unit and in-hospital mortality. Results Among 5019 critically ill patients with covid-19, 14.0% (701/5019) had in-hospital cardiac arrest, 57.1% (400/701) of whom received cardiopulmonary resuscitation. Patients who had in-hospital cardiac arrest were older (mean age 63 (standard deviation 14) v 60 (15) years), had more comorbidities, and were more likely to be admitted to a hospital with a smaller number of intensive care unit beds compared with those who did not have in-hospital cardiac arrest. Patients who received cardiopulmonary resuscitation were younger than those who did not (mean age 61 (standard deviation 14) v 67 (14) years). The most common rhythms at the time of cardiopulmonary resuscitation were pulseless electrical activity (49.8%, 199/400) and asystole (23.8%, 95/400). 48 of the 400 patients (12.0%) who received cardiopulmonary resuscitation survived to hospital discharge, and only 7.0% (28/400) survived to hospital discharge with normal or mildly impaired neurological status. Survival to hospital discharge differed by age, with 21.2% (11/52) of patients younger than 45 years surviving compared with 2.9% (1/34) of those aged 80 or older. Conclusions Cardiac arrest is common in critically ill patients with covid-19 and is associated with poor survival, particularly among older patients.

Published
2020

21. Rituximab or Cyclosporine in the Treatment of Membranous Nephropathy

Author

Fervenza, Fernando C., primary, Appel, Gerald B., additional, Barbour, Sean J., additional, Rovin, Brad H., additional, Lafayette, Richard A., additional, Aslam, Nabeel, additional, Jefferson, Jonathan A., additional, Gipson, Patrick E., additional, Rizk, Dana V., additional, Sedor, John R., additional, Simon, James F., additional, McCarthy, Ellen T., additional, Brenchley, Paul, additional, Sethi, Sanjeev, additional, Avila-Casado, Carmen, additional, Beanlands, Heather, additional, Lieske, John C., additional, Philibert, David, additional, Li, Tingting, additional, Thomas, Leslie F., additional, Green, Dolly F., additional, Juncos, Luis A., additional, Beara-Lasic, Lada, additional, Blumenthal, Samuel S., additional, Sussman, Amy N., additional, Erickson, Stephen B., additional, Hladunewich, Michelle, additional, Canetta, Pietro A., additional, Hebert, Lee A., additional, Leung, Nelson, additional, Radhakrishnan, Jay, additional, Reich, Heather N., additional, Parikh, Samir V., additional, Gipson, Debbie S., additional, Lee, Dominic K., additional, da Costa, Bruno R., additional, Jüni, Peter, additional, and Cattran, Daniel C., additional

Published
2019
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25. A Multicenter Randomized Controlled Trial of Rituximab versus Cyclosporine in the Treatment of Idiopathic Membranous Nephropathy (MENTOR)

Author

Fervenza, Fernando C., Canetta, Pietro A., Barbour, Sean J., Lafayette, Richard A., Rovin, Brad H., Aslam, Nabeel, Hladunewich, Michelle A., Irazabal, Maria V., Sethi, Sanjeev, Gipson, Debbie S., Reich, Heather N., Brenchley, Paul, Kretzler, Matthias, Radhakrishnan, Jai, Hebert, Lee A., Gipson, Patrick E., Thomas, Leslie F., McCarthy, Ellen T., Appel, Gerald B., Jefferson, J. Ashley, Eirin, Alfonso, Lieske, John C., Hogan, Marie C., Greene, Eddie L., Dillon, John J., Leung, Nelson, Sedor, John R., Rizk, Dana V., Blumenthal, Samuel S., Lasic, Lada B., Juncos, Luis A., Green, Dollie F., Simon, James, Sussman, Amy N., Philibert, David, and Cattran, Daniel C.

Abstract

AbstractBackground:Idiopathic membranous nephropathy remains the leading cause of nephrotic syndrome in Caucasian adults. Immunosuppressive therapy with cyclosporine (CSA) is often successful in reducing proteinuria, but its use is associated with a high relapse rate. Rituximab, a monoclonal antibody that specifically targets CD20 on the surface of B-cells, is effective in achieving a complete remission of proteinuria in patients with idiopathic membranous nephropathy. However, whether rituximab is as effective as CSA in inducing and maintaining complete or partial remission of proteinuria in these patients is unknown. The membranous nephropathy trial of rituximab (MENTOR) hypothesizes that B-cell targeting with rituximab is non-inferior to CSA in inducing long-term remission of proteinuria. Methods and Design:Patients with idiopathic membranous nephropathy, proteinuria ≥5 g/24 h, and a minimum of 3 months of Angiotensin-II blockade will be randomized into a 12-month treatment period with IV rituximab, 1,000 mg (2 infusions, 14 days apart; repeated at 6 months if a substantial reduction in proteinuria (equal to or >25) is seen at 6 months) or oral CSA 3.5-5 mg/kg/day for 6 months (continued for another 6 months if a substantial reduction in proteinuria (equal to or >25) is seen at 6 months). The efficacy of treatment will be assessed by the remission status (based on changes in proteinuria) at 24 months from randomization. Patient safety will be assessed via collection of adverse event data and evaluation of pre- and posttreatment laboratory data. At the 6-month post-randomization visit, patients who have been randomized to either CSA or rituximab but who do not have a reduction in proteinuria ≥25 (confirmed on repeat measurements within 2 weeks) will be considered treatment failures and exit the study. Discussion:This study will test for the first time whether treatment with rituximab is non-inferior to CSA in inducing long-term remission (complete or partial) of proteinuria in patients with idiopathic membranous nephropathy.© 2015 S. Karger AG, Basel

Published
2015
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