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Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US
- Source :
- JAMA Internal Medicine
- Publication Year :
- 2020
- Publisher :
- American Medical Association (AMA), 2020.
-
Abstract
- Importance: The US is currently an epicenter of the coronavirus disease 2019 (COVID-19) pandemic, yet few national data are available on patient characteristics, treatment, and outcomes of critical illness from COVID-19. Objectives: To assess factors associated with death and to examine interhospital variation in treatment and outcomes for patients with COVID-19. Design, Setting, and Participants: This multicenter cohort study assessed 2215 adults with laboratory-confirmed COVID-19 who were admitted to intensive care units (ICUs) at 65 hospitals across the US from March 4 to April 4, 2020. Exposures: Patient-level data, including demographics, comorbidities, and organ dysfunction, and hospital characteristics, including number of ICU beds. Main Outcomes and Measures: The primary outcome was 28-day in-hospital mortality. Multilevel logistic regression was used to evaluate factors associated with death and to examine interhospital variation in treatment and outcomes. Results: A total of 2215 patients (mean [SD] age, 60.5 [14.5] years; 1436 [64.8%] male; 1738 [78.5%] with at least 1 chronic comorbidity) were included in the study. At 28 days after ICU admission, 784 patients (35.4%) had died, 824 (37.2%) were discharged, and 607 (27.4%) remained hospitalized. At the end of study follow-up (median, 16 days; interquartile range, 8-28 days), 875 patients (39.5%) had died, 1203 (54.3%) were discharged, and 137 (6.2%) remained hospitalized. Factors independently associated with death included older age (≥80 vs
- Subjects :
- medicine.medical_specialty
business.industry
010102 general mathematics
Organ dysfunction
Odds ratio
medicine.disease
01 natural sciences
Intensive care unit
Comorbidity
law.invention
03 medical and health sciences
0302 clinical medicine
Interquartile range
law
Intensive care
Internal medicine
Internal Medicine
Medicine
030212 general & internal medicine
0101 mathematics
medicine.symptom
business
Body mass index
Cohort study
Subjects
Details
- ISSN :
- 21686106
- Volume :
- 180
- Database :
- OpenAIRE
- Journal :
- JAMA Internal Medicine
- Accession number :
- edsair.doi.dedup.....d4a6e3cb2679eab2932123f119a7c4ae