1. From a Sequential Chemo-Enzymatic Approach to a Continuous Process for HMF Production from Glucose
- Author
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Gimbernat, Alexandra, Guehl, Marie, Ferreira, Nicolas Lopes, Heuson, Egon, Dhulster, Pascal, Capron, Mickael, Dumeignil, Franck, Delcroix, Damien, Girardon, Jean Sébastien, Froidevaux, Rénato, Institut Charles Viollette (ICV) - EA 7394 (ICV), Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Institut National de la Recherche Agronomique (INRA)-Université d'Artois (UA)-Institut Supérieur d'Agriculture, Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Centrale Lille Institut (CLIL)-Université d'Artois (UA)-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Lille, IFP Energies nouvelles (IFPEN), This research was funded by IFP Energies nouvelles for funding these studies. Chevreul Institute (FR 2638), Ministère de l’Enseignement Supérieur et de la Recherche, Région Hauts-de-France (CPER ALIBIOTECH), REALCAT platform (‘Future Investments’ program (PIA), with the contractual reference ‘ANR-11-EQPX-0037′) and FEDER are acknowledged for supporting and funding partially this work., ANR-11-EQPX-0037,REALCAT,Plateforme intégREe AppLiquée au criblage haut débit de CATalyseurs pour les bioraffineries(2011), Université d'Artois (UA)-Institut National de la Recherche Agronomique (INRA)-Université du Littoral Côte d'Opale (ULCO)-Institut Supérieur d'Agriculture-Université de Lille, Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), ENSCL, Université de Lille, CNRS, INRA, ISA, Centrale Lille, Univ. Artois, Univ. Littoral Côte d’Opale, Institut Charles Viollette (ICV) - EA 7394 [ICV], Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS], IFP Energies nouvelles [IFPEN], Unité de Catalyse et de Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Ecole Centrale de Lille-Ecole Nationale Supérieure de Chimie de Lille (ENSCL)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), and ANR-11-EQPX-0037/11-EQPX-0037,REALCAT,Plateforme intégREe AppLiquée au criblage haut débit de CATalyseurs pour les bioraffineries(2011)
- Subjects
chemo-enzymatic catalysis ,biomass ,5-hydroxymethylfurfural (HMF) ,lcsh:Chemical technology ,lcsh:Chemistry ,lcsh:QD1-999 ,[CHIM]Chemical Sciences ,lcsh:TP1-1185 ,(bio) catalysis ,glucose ,chemo‐enzymatic catalysis ,HMF ,(bio)catalysis - Abstract
International audience; Notably available from the cellulose contained in lignocellulosic biomass, glucose is a highly attractive substrate for eco-efficient processes towards high-value chemicals. A recent strategy for biomass valorization consists on combining biocatalysis and chemocatalysis to realise the so-called chemo-enzymatic or hybrid catalysis. Optimisation of the glucose conversion to 5-hydroxymethylfurfural (HMF) is the object of many research efforts. HMF can be produced by chemo-catalyzed fructose dehydration, while fructose can be selectively obtained from enzymatic glucose isomerization. Despite recent advances in HMF production, a fully integrated efficient process remains to be demonstrated. Our innovative approach consists on a continuous process involving enzymatic glucose isomerization, selective arylboronic-acid mediated fructose complexation/transportation, and chemical fructose dehydration to HMF. We designed a novel reactor based on two aqueous phases dynamically connected via an organic liquid membrane, which enabled substantial enhancement of glucose conversion (70%) while avoiding intermediate separation steps. Furthermore, in the as-combined steps, the use of an immobilized glucose isomerase and an acidic resin facilitates catalyst recycling
- Published
- 2018