1. Preliminary quantitative evaluation of radiation-induced DNA damage in peripheral blood lymphocytes after cardiac dual-isotope imaging.
- Author
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Okuda K, Watanabe N, Hashimoto M, Doai M, Kawai Y, Takahashi T, Arikawa T, Ooiso K, Sunatani Y, Iwabuchi K, Kajinami K, and Matoba M
- Subjects
- Aged, Biomarkers blood, DNA Breaks, Double-Stranded, Fatty Acids, Female, Histones blood, Humans, Iodine Radioisotopes adverse effects, Iodobenzenes, Male, Middle Aged, Myocardial Perfusion Imaging methods, Prospective Studies, Radiopharmaceuticals adverse effects, Thallium Radioisotopes adverse effects, Tomography, Emission-Computed, Single-Photon methods, DNA Damage, Lymphocytes metabolism, Lymphocytes radiation effects, Myocardial Perfusion Imaging adverse effects, Tomography, Emission-Computed, Single-Photon adverse effects
- Abstract
DNA double-strand breaks (DSBs) of peripheral blood lymphocyte were prospectively assessed in 9 patients who were injected with
201 Tl-chloride and123 I-beta-methyl-p-iodophenyl-pentadecanoic acid in dual-isotope imaging. Phosphorylated H2AX (γH2AX) was used as a biomarker for detecting DSBs, and the mean number of γH2AX foci per cell was measured microscopically. Mean γH2AX foci before administration of radiopharmaceuticals and at 3, 6, and 24 h following administration were 0.22 ± 0.34, 0.10 ± 0.14, 0.59 ± 0.46, and 0.52 ± 0.40, respectively (p = n.s. for all combinations)., (Copyright © 2019 Elsevier Ltd. All rights reserved.)- Published
- 2019
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