22 results on '"Thépot V"'
Search Results
2. FREE ORAL COMMUNICATIONS 2: ALCOHOL AND LIVER—CLINICAL RESEARCHO2.1RAPID DECLINE OF LIVER STIFFNESS WITH ALCOHOL WITHDRAWAL IN HEAVY DRINKERS
- Author
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Trabut, J., Thépot, V., Nalpas, B., and Pol, S.
- Published
- 2011
- Full Text
- View/download PDF
3. FREE ORAL COMMUNICATIONS 2: ALCOHOL AND LIVER—CLINICAL RESEARCHO2.1RAPID DECLINE OF LIVER STIFFNESS WITH ALCOHOL WITHDRAWAL IN HEAVY DRINKERS
- Author
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Trabut, J., Thépot, V., Nalpas, B., Pol, S., Mueller, S., Millonig, G., Stickel, F., Longerich, T., Schirmacher, P., Seitz, H. K., Leclercq, S., de Timary, P., Delzenne, N., Cani, P., Pitel, A. L., Chételat, G., Le Berre, A. P., Desgranges, B., Eustache, F., Beaunieux, H., Quin, H., Glassen, K., Linhart, K. B., Waldherr, R., and Buko, V.
- Abstract
Background and aims. Measurement of liver stiffness using real-time elastography appears as a promising tool to evaluate the severity of chronic liver diseases. Previous studies in patients with alcoholic liver disease have suggested that fibrosis was the only histological parameter to influence liver stiffness. To challenge this hypothesis, we have prospectively tested the short-term impact of alcohol withdrawal on liver stiffness value. Methods. All patients hospitalized for alcohol withdrawal in our Liver Unit between September 2008 and December 2010 had a liver stiffness determination (using a FibroScan® device) at entry (D0) and 7 days after alcohol withdrawal (D7). Stiffness values were compared using non-parametric test for paired-values. We compared (i) the 10 measures performed at D0 and at D7 for each patient; (ii) the variation of the median result of all patients (using Wilcoxon test in both cases). Results. A total of 138 patients were included in the study [median alcohol consumption: 150g/day (range: 40-400); hepatitis C: n=22 (15.9%); cirrhosis: n=29 (21.0%)]. From D0 to D7, the liver stiffness decreased significantly in 61 patients (44.2%) and increased significantly in 18 (13.0%). Considering all patients, median liver stiffness value decreased from 7.25 to kPa (P
- Published
- 2017
4. THU-370 - Relationship between Alcohol use Disorders and Response to Antiviral Treatment on the Prognosis of Cirrhotic Patients with Chronic Hepatitis C
- Author
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Sultanik, P., Kramer, L., Bouam, S., Vallet-Pichard, A., Fontaine, H., Corouge, M., Thepot, V., Lavielle, B., Sogni, P., Pol, S., and Mallet, V.
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- 2016
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- View/download PDF
5. Hépatite alcoolique aiguë
- Author
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Trabut, J.-B., primary, Thépot, V., additional, Sogni, P., additional, and Pol, S., additional
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- 2012
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6. 428 RAPID DECLINE OF LIVER STIFFNESS FOLLOWING ALCOHOL WITHDRAWAL IN HEAVY DRINKERS
- Author
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Trabut, J.-B., primary, Thépot, V., additional, Nalpas, B., additional, and Pol, S., additional
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- 2010
- Full Text
- View/download PDF
7. Improvement of the CD4 cell count after alcohol withdrawal in HIV-positive alcoholic patients
- Author
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Pol, S, primary, Artru, P, additional, Thépot, V, additional, Berthelot, P, additional, and Nalpas, B, additional
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- 1996
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8. Hepatocellular carcinoma in alcoholics
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Nalpas, B., primary, Pol, S., additional, Thépot, V., additional, Berthelot, P., additional, and Brechot, C., additional
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- 1995
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9. Dissociation of TNF and IL-1β production in chronic alcoholics without cirritosis
- Author
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Pol, S., primary, Nalpas, B., additional, Thépot, V., additional, Berthclot, P., additional, and Chatenoud, L., additional
- Published
- 1991
- Full Text
- View/download PDF
10. FREE ORAL COMMUNICATIONS 2: ALCOHOL AND LIVER—CLINICAL RESEARCHO2.1RAPID DECLINE OF LIVER STIFFNESS WITH ALCOHOL WITHDRAWAL IN HEAVY DRINKERS
- Author
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Trabut, J., Thépot, V., Nalpas, B., Pol, S., Mueller, S., Millonig, G., Stickel, F., Longerich, T., Schirmacher, P., Seitz, H. K., Leclercq, S., de Timary, P., Delzenne, N., Cani, P., Pitel, A. L., Chételat, G., Le Berre, A. P., Desgranges, B., Eustache, F., Beaunieux, H., Quin, H., Glassen, K., Linhart, K. B., Waldherr, R., Buko, V., Trabut, J., Thépot, V., Nalpas, B., Pol, S., Mueller, S., Millonig, G., Stickel, F., Longerich, T., Schirmacher, P., Seitz, H. K., Leclercq, S., de Timary, P., Delzenne, N., Cani, P., Pitel, A. L., Chételat, G., Le Berre, A. P., Desgranges, B., Eustache, F., Beaunieux, H., Quin, H., Glassen, K., Linhart, K. B., Waldherr, R., and Buko, V.
- Abstract
Background and aims. Measurement of liver stiffness using real-time elastography appears as a promising tool to evaluate the severity of chronic liver diseases. Previous studies in patients with alcoholic liver disease have suggested that fibrosis was the only histological parameter to influence liver stiffness. To challenge this hypothesis, we have prospectively tested the short-term impact of alcohol withdrawal on liver stiffness value. Methods. All patients hospitalized for alcohol withdrawal in our Liver Unit between September 2008 and December 2010 had a liver stiffness determination (using a FibroScan® device) at entry (D0) and 7 days after alcohol withdrawal (D7). Stiffness values were compared using non-parametric test for paired-values. We compared (i) the 10 measures performed at D0 and at D7 for each patient; (ii) the variation of the median result of all patients (using Wilcoxon test in both cases). Results. A total of 138 patients were included in the study [median alcohol consumption: 150g/day (range: 40-400); hepatitis C: n=22 (15.9%); cirrhosis: n=29 (21.0%)]. From D0 to D7, the liver stiffness decreased significantly in 61 patients (44.2%) and increased significantly in 18 (13.0%). Considering all patients, median liver stiffness value decreased from 7.25 to kPa (P<0.001). The stage of fibrosis indicated by liver stiffness changed in 47 patients between D0 and D7 (decrease in 33 and increase in 14). Conclusion. Liver stiffness decreases significantly in nearly half of alcoholic patients after only 7 days of abstinence. This result strongly suggests that non-fibrotic lesions (such as inflammatory ones) may influence liver stiffness. From a practical point of view, it also shows that variation in alcohol consumption must be taken into account for the interpretation of liver stiffness value
11. PreS(2) antigens in recombinant vaccines against HBV enhance the human immune response. Preliminary results of a randomized trial
- Author
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Nalpas, B., primary, Thépot, V., additional, Couroucć, A.M., additional, Tron, F., additional, Saliou, P., additional, Reéchot, C., additional, and Berthelot, P., additional
- Published
- 1989
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12. Hepatitis C viremia and anti-HCV antibodies in alcoholics
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Nalpas, B., Thiers, V., Pol, S., Driss, F., Thepot, V., Berthelot, P., and Brechot, C.
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- 1992
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13. Is the Intestinal Bacterial Community in the Australian Rabbitfish Siganus fuscescens Influenced by Seaweed Supplementation or Geography?
- Author
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Thépot V, Slinger J, Rimmer MA, Paul NA, and Campbell AH
- Abstract
We recently demonstrated that dietary supplementation with seaweed leads to dramatic improvements in immune responses in S. fuscescens , a candidate species for aquaculture development in Asia. Here, to assess whether the immunostimulatory effect was facilitated by changes to the gut microbiome, we investigated the effects of those same seaweed species and four commercial feed supplements currently used in aquaculture on the bacterial communities in the hindgut of the fish. Since we found no correlations between the relative abundance of any particular taxa and the fish enhanced innate immune responses, we hypothesised that S. fuscescens might have a core microbiome that is robust to dietary manipulation. Two recently published studies describing the bacteria within the hindgut of S. fuscescens provided an opportunity to test this hypothesis and to compare our samples to those from geographically distinct populations. We found that, although hindgut bacterial communities were clearly and significantly distinguishable between studies and populations, a substantial proportion (55 of 174 taxa) were consistently detected across all populations. Our data suggest that the importance of gut microbiota to animal health and the extent to which they can be influenced by dietary manipulations might be species-specific or related to an animals' trophic level.
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- 2022
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14. Seaweed dietary supplements enhance the innate immune response of the mottled rabbitfish, Siganus fuscescens.
- Author
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Thépot V, Campbell AH, Paul NA, and Rimmer MA
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- Animals, Diet veterinary, Dietary Supplements analysis, Animal Feed analysis, Chlorophyta chemistry, Immunity, Innate drug effects, Perciformes immunology, Phaeophyceae chemistry, Rhodophyta chemistry, Seaweed chemistry
- Abstract
Disease is one of the major bottlenecks for aquaculture development, costing the industry in excess of US $6 billion each year. The increase in pressure to phase out some traditional approaches to disease control (e.g. antibiotics) is pushing farmers to search for alternatives to treat and prevent disease outbreaks, which do not have detrimental consequences (e.g. antibiotic resistance). We tested the effects of eleven seaweed species and four established fish immunostimulants on the innate immune response (cellular and humoral immunity) of the rabbitfish Siganus fuscescens. All supplements including different seaweeds from the three groups (Chlorophyta, Phaeophyta and Rhodophyta) were included in the fish pellet at 3% (by weight) and had variably positive effects across the four innate immune parameters we measured compared to control fish. Diets supplemented with the red seaweed Asparagopsis taxiformis and the brown seaweed Dictyota intermedia led to the largest boosts in humoral and cellular innate immune defences, including particularly significant increases in haemolytic activity. Diets supplemented with Ulva fasciata also led to promising positive effects on the fish innate immune responses. We conclude that dietary seaweed supplements can boost the immune response of S. fuscescens and thus the top three species highlighted in this study should be further investigated for this emerging aquaculture species and other fish species., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Published
- 2021
- Full Text
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15. [Prognosis assessment of alcoholic liver disease: how and why?].
- Author
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Trabut JB, Thépot V, Terris B, Sogni P, Nalpas B, and Pol S
- Subjects
- Biomarkers, Female, Humans, Male, Prognosis, Liver pathology, Liver Cirrhosis diagnosis, Liver Diseases, Alcoholic diagnosis
- Abstract
Alcoholic liver disease (ALD) causes more than 5000 deaths per year in France. Most of those deaths could be prevented by an early diagnosis, which would give the patients the opportunity to modify their alcohol consumption while liver lesions are still reversible. Hepatic histology is the main parameter that predicts morbidity and mortality in patients with ALD. Non-invasive methods such as biomarker tests (e.g. FibroTest(®) or FibroMetre A(®)) or hepatic elastography (FibroScan(®)) may allow diagnosing alcohol-induced liver lesion without systematic biopsy. Despite promising preliminary results, those methods are not validated yet in ALD. A validation of non-invasive methods for ALD could allow a large screening of the severe forms of this pathology., (Copyright © 2013 Elsevier Masson SAS. All rights reserved.)
- Published
- 2014
- Full Text
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16. Management of hepatitis C virus infection in heavy drinkers.
- Author
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Costentin CE, Trabut JB, Mallet V, Darbeda S, Thépot V, Nalpas B, Badin de Montjoye B, Lavielle B, Vallet-Pichard A, Sogni P, and Pol S
- Subjects
- Adult, Age Factors, Alcohol Drinking psychology, Antiviral Agents therapeutic use, Case Management, Case-Control Studies, Cohort Studies, Comorbidity, Data Interpretation, Statistical, Female, Genotype, Health Services Accessibility, Hepatitis B Surface Antigens analysis, Humans, Liver Function Tests, Male, Middle Aged, Retrospective Studies, Sex Factors, Socioeconomic Factors, Temperance, Treatment Outcome, Alcoholism complications, Hepatitis C complications, Hepatitis C drug therapy
- Abstract
Aim: Optimal management of hepatitis C virus (HCV) infection is controversial in heavy drinkers. We compared the management of HCV infection of heavy drinkers with that of patients without a history of alcohol abuse., Methods: In a retrospective case-control study, 69 HCV-infected heavy drinkers [daily alcohol consumption at referral above 60 g/day, hereafter 'alcohol group'] were compared with matched HCV-infected patients with low alcohol consumption (<40 g/day, 'control group')., Results: Patients of the 'alcohol group' were younger (42 vs. 45 years, P = 0.05), more often male (69.6 vs. 56.5%, P = 0.11) and had been infected by intravenous drug use (85.5 vs. 45.0%, P < 0.0001). The percentage of patients with a recommendation for treatment according to the French 2002 consensus (bridging fibrosis or genotype 2 or 3) was 52 of 69 (75.4%) in both groups, while the proportion of patients treated was higher in the control group (71.0 vs. 44.9%, P = 0.002). In the 'alcohol group', patients had better access to treatment if they were employed or consumed 170 g/day or less at first referral. Sustained virological response (SVR) was obtained in 10 of 31 patients (32.3%) of the 'alcohol group' vs. 8 of 31 patients (25.8%) of the control group matched for genotype and type of treatment (P = 0.58)., Conclusion: Heavy drinkers are less often considered for antiviral therapy compared with patients without a history of alcohol abuse. However, once treatment is actually initiated, SVR rates are comparable with those achieved in non-drinkers despite the continuation of alcohol consumption during therapy in some patients.
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- 2013
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17. Rapid decline of liver stiffness following alcohol withdrawal in heavy drinkers.
- Author
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Trabut JB, Thépot V, Nalpas B, Lavielle B, Cosconea S, Corouge M, Vallet-Pichard A, Fontaine H, Mallet V, Sogni P, and Pol S
- Subjects
- Adult, Aged, Aged, 80 and over, Alcoholism rehabilitation, Aspartate Aminotransferases blood, Cohort Studies, Disease Progression, Elasticity Imaging Techniques, Female, Hepatitis C pathology, Humans, Liver Cirrhosis pathology, Liver Function Tests, Male, Middle Aged, Prospective Studies, Alcoholism pathology, Liver pathology, Liver Diseases, Alcoholic pathology, Substance Withdrawal Syndrome pathology
- Abstract
Background: Measurement of liver stiffness (LS) using real-time elastography appears as a promising tool to evaluate the severity of chronic liver diseases. Previous studies in patients with alcoholic liver disease have suggested that fibrosis was the only histological parameter to influence LS. To challenge this hypothesis, we have prospectively tested the short-term impact of alcohol withdrawal on LS value., Methods: Patients hospitalized for alcohol withdrawal in our Liver and Addiction Unit between 2007 and 2010 had an LS determination at entry (D0) and 7 days after alcohol withdrawal (D7). LS value was given as the median of 10 measurements performed with a FibroScan(®) device. For a given patient, variation of LS was considered as significant when the comparison of the 10 measurements at D0 and at D7 yielded a p-value under 0.05 (Wilcoxon test)., Results: One hundred and thirty-seven patients were included in the study (median alcohol consumption: 150 g/d; hepatitis C: n = 21 [15.6%]). Considering all patients, median LS value decreased from 7.2 to 6.1 kPa between D0 and D7 (p = 0.00001, paired Wilcoxon test). LS decreased significantly in 62 patients (45.3%), and there was a reduction in the estimated stage of fibrosis in 32 (23.3%). LS increased significantly in 16 patients (11.7%). Subgroup analyses revealed that the decrease in LS was still significant in patients with or without hepatitis C infection, and aspartate transaminase level below or above 100 UI/l., Conclusions: LS decreases significantly in nearly half of heavy drinkers after only 7 days of abstinence. This result strongly suggests that nonfibrotic lesions (such as the presence of alcoholic hepatitis) may influence LS. From a practical point of view, it also shows that variation of alcohol consumption must be taken into account for the interpretation of LS value., (Copyright © 2012 by the Research Society on Alcoholism.)
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- 2012
- Full Text
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18. [Alcoholic hepatitis].
- Author
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Trabut JB, Thépot V, Sogni P, and Pol S
- Subjects
- Diagnosis, Differential, Diagnostic Imaging methods, Disease Progression, Hepatitis, Alcoholic complications, Hepatitis, Alcoholic diagnosis, Hepatitis, Alcoholic etiology, Humans, Infections etiology, Infections therapy, Prognosis, Hepatitis, Alcoholic therapy
- Abstract
Alcoholic hepatitis is one of the most severe presentations of alcoholic liver disease. It is usually revealed by the recent onset of jaundice in a patient with alcoholic cirrhosis. Maddrey's discriminant function can help to recognize patients with poor prognosis (the 6-month mortality is above 50% when it exceeds 32). Corticosteroids increase survival in those patients with high risk of death. Other treatments (pentoxifylline, N-acetyl-cysteine or enteral nutrition) need to be investigated further before to recommend their routine use instead of, or in association with, corticoids. Liver transplantation can be proposed to highly selected patients who do not respond to medical therapy. In any case, long-term prognosis will primarily depend on the maintenance of alcohol abstinence., (Copyright © 2012 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.)
- Published
- 2012
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19. Triggering of acute alcoholic hepatitis by alpha-interferon therapy.
- Author
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Zylberberg H, Fontaine H, Thépot V, Nalpas B, Bréchot C, and Pol S
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- Acute Disease, Adult, Alanine Transaminase blood, Aspartate Aminotransferases blood, Disease Progression, Hepatitis C, Chronic complications, Hepatitis, Alcoholic etiology, Humans, Male, Middle Aged, Hepatitis C, Chronic therapy, Hepatitis, Alcoholic physiopathology, Interferon-alpha adverse effects
- Abstract
Background/aims: Alcohol may induce autoimmunity by recognition of acetaldehyde-modified proteins which may be implicated in the pathogenicity of acute alcoholic hepatitis. We report here the potential role of alpha-interferon, a potent inducer of the autoimmunity process, in inducing alcoholic hepatitis., Methods: We analyzed clinical, biological, virological and histological features in two cases where alpha-interferon treatment for HCV-related hepatitis led to a marked increase in aminotransferase activities., Results: alpha-interferon as treatment of HCV-related hepatitis seemed to exacerbate acute alcoholic hepatitis despite moderate alcohol consumption. In Case 1, moderate daily alcohol intake of 40 g during therapy led to biopsy-proven acute alcoholic hepatitis, while the same consumption before therapy did not. In Case 2, before treatment, the liver biopsy showed mild acute alcoholic hepatitis; aminotransferases increased during alpha-interferon therapy, although no increase in alcohol intake was observed., Conclusion: alpha-interferon therapy by its immunomodulatory properties could be implicated in alteration of the course of acute alcoholic hepatitis. These observations emphasize that the decision to treat with alpha-interferon when there is even moderate alcohol consumption should be carefully weighted in HCV-infected patients.
- Published
- 1999
- Full Text
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20. ESBRA 1997 Award lecture: relationship between excessive alcohol drinking and viral infections.
- Author
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Nalpas B, Pol S, Thépot V, Zylberberg H, Berthelot P, and Bréchot C
- Subjects
- Alcoholism epidemiology, Comorbidity, Hepacivirus drug effects, Hepatitis B virus drug effects, Hepatitis B, Chronic epidemiology, Hepatitis C, Chronic epidemiology, Humans, Viral Load, Virus Replication drug effects, Virus Replication physiology, Alcoholism virology, Hepatitis B, Chronic virology, Hepatitis C, Chronic virology
- Abstract
Several epidemiological studies suggest that chronic alcoholics are at risk of viral infections. Clinical and basic research has demonstrated that alcohol not only worsens the natural history of chronic viral hepatitis, but also seems to interact with the viral replication cycle leading to an unusual serum virological profile and/or modification in the serum concentration of viral particles. Infections with hepatitis B and C viruses are a major risk for the development of hepatocellular carcinoma in excessive drinkers who should be protected against these viruses.
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- 1998
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21. A comparative study between carbohydrate-deficient transferrin and gamma-glutamyltransferase for the diagnosis of excessive drinking in a liver unit.
- Author
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Nalpas B, Hispard E, Thépot V, Pot S, Dally S, and Berthelot P
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Sex Factors, Transferrin analysis, Liver Diseases, Alcoholic diagnosis, Transferrin analogs & derivatives, gamma-Glutamyltransferase blood
- Abstract
Aim: To compare the efficacy of carbohydrate-deficient transferrin and gamma-glutamyltransferase for the diagnosis of excessive alcohol intake in patients admitted in a liver unit., Methods: The 346 patients were divided into three groups of alcoholics: 57 patients (31 men, 26 women) with a normal liver, 77 patients (51 men, 26 women) with non-cirrhotic alcoholic liver disease, and 61 patients (43 men, 18 women) with alcoholic cirrhosis; and three groups of non-alcoholics: 35 abstainers (21 men, 14 women), and 58 healthy blood donors (26 men, 32 women), and 58 patients (32 men, 26 women) who had a non-alcoholic liver disease. Carbohydrate-deficient transferrin and gamma-glutamyltransferase were measured at admission using commercially available kits., Results: Carbohydrate-deficient transferrin was more sensitive than gamma-glutamyltransferase in patients without alcoholic liver disease, in both men (85 vs 54%) and women (64 vs 36%). Carbohydrate-deficient transferrin sensitivity decreased slightly but not significantly according to the severity of the liver disease in men and women. The sensitivity of gamma-glutamyltransferase which was low in men and women without alcoholic liver disease, improved in groups with moderate or severe alcoholic liver disease: not less than 80% in men and up to 100% in women. The specificity of carbohydrate-deficient transferrin in patients with non-alcoholic liver disease was consistently higher than that of gamma-glutamyltransferase (80% vs 60%)., Conclusions: In liver units, carbohydrate-deficient transferrin can help to identify excessive drinkers without liver disease with a higher efficacy than that of gamma-glutamyltransferase; carbohydrate-deficient transferrin can also be used to distinguish between alcoholics with moderate liver disease and patients with non-alcoholic liver diseases.
- Published
- 1997
- Full Text
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22. [Sero-epidemiology of hepatitis A: alcoholic patients are a group at risk].
- Author
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Aparicio T, Driss F, Thépot V, Hispard E, Berthelot P, and Nalpas B
- Subjects
- Adolescent, Adult, Aged, Alcoholism complications, Female, Hepatitis A immunology, Hepatitis B epidemiology, Hepatitis B Antibodies analysis, Hepatitis C epidemiology, Hepatitis C Antibodies analysis, Humans, Male, Middle Aged, Prevalence, Reference Values, Retrospective Studies, Risk Factors, Socioeconomic Factors, Hepatitis A epidemiology, Hepatitis Antibodies analysis, Liver Cirrhosis, Alcoholic virology, Liver Diseases, Alcoholic virology
- Abstract
Objectives: The possibility of "community-acquired" viral infection has been suggested in alcoholics. In order to assess this hypothesis, we evaluated the prevalence of antibodies against hepatitis A virus, a oro-fecally transmitted virus, in heavy drinkers., Patients and Methods: We retrospectively studied 258 heavy drinkers, 188 males and 70 females, divided into sub-groups of increasing age, and compared them to 277 similarly classified blood donors., Results: The prevalence of serum anti-hepatitis A antibodies was significantly higher in alcoholics than in controls (64.7 vs 52.3%, P < 0.01). The difference was particularly marked in patients younger than 45 years old (56.2 vs 39.1%, P < 0.01). In the alcoholics, there was no correlation between the prevalence of anti-hepatitis A antibodies and the socioeconomic level, the quantity of alcohol ingested, or the severity of the underlying liver disease., Conclusion: These results suggest that alcoholism is, per se, a risk factor for viral infections.
- Published
- 1995
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