1. In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase
- Author
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Arthur I. Salhanick, Mary E. Bowling, Terri Witman-Jones, Wai C. Wong, Christine Keiper, Furahi Achebe, Ning Qi, Kevin B. Clairmont, Steven Magnuson, Bullock William H, Derek B. Lowe, Ann-Marie Campbell, Zhenqiu Hong, Harold Kluender, Ming Wang, James H. Cook, and Mareli Rodriguez
- Subjects
Carboxylic Ester Hydrolases ,Clinical Biochemistry ,Triacylglycerol lipase ,Pharmaceutical Science ,Hormone-sensitive lipase ,Biochemistry ,Structure-Activity Relationship ,Drug Discovery ,Sterol esterase ,Structure–activity relationship ,Hypoglycemic Agents ,Urea ,Lipase ,Enzyme Inhibitors ,Molecular Biology ,chemistry.chemical_classification ,biology ,Organic Chemistry ,Isoxazoles ,Sterol Esterase ,In vitro ,Enzyme ,chemistry ,biology.protein ,Molecular Medicine - Abstract
A series of (5-(2H)-isoxazolonyl) ureas were developed as nanomolar inhibitors of hormone-sensitive lipase, an enzyme of potential importance in the treatment of diabetes.
- Published
- 2004