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In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase
- Source :
- Bioorganicmedicinal chemistry letters. 14(12)
- Publication Year :
- 2004
-
Abstract
- A series of (5-(2H)-isoxazolonyl) ureas were developed as nanomolar inhibitors of hormone-sensitive lipase, an enzyme of potential importance in the treatment of diabetes.
- Subjects :
- Carboxylic Ester Hydrolases
Clinical Biochemistry
Triacylglycerol lipase
Pharmaceutical Science
Hormone-sensitive lipase
Biochemistry
Structure-Activity Relationship
Drug Discovery
Sterol esterase
Structure–activity relationship
Hypoglycemic Agents
Urea
Lipase
Enzyme Inhibitors
Molecular Biology
chemistry.chemical_classification
biology
Organic Chemistry
Isoxazoles
Sterol Esterase
In vitro
Enzyme
chemistry
biology.protein
Molecular Medicine
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 14
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....b8eea09b0b8feffc5f1002294eca3d21