1. Combined pancreaticoduodenectomy and colon resection for locally advanced peri-ampullary tumours: analysis of peri-operative morbidity and mortality.
- Author
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Temple SJ, Kim PT, Serrano PE, Kagedan D, Cleary SP, Moulton CA, McGilvray ID, Gallinger S, Greig PD, and Wei AC
- Subjects
- Academic Medical Centers, Adult, Aged, Blood Loss, Surgical, Chemotherapy, Adjuvant, Digestive System Neoplasms mortality, Digestive System Neoplasms pathology, Female, Hospitals, High-Volume, Humans, Length of Stay, Male, Middle Aged, Neoadjuvant Therapy, Ontario, Operative Time, Postoperative Hemorrhage etiology, Postoperative Hemorrhage mortality, Retrospective Studies, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Young Adult, Colectomy adverse effects, Colectomy mortality, Digestive System Neoplasms surgery, Pancreaticoduodenectomy adverse effects, Pancreaticoduodenectomy mortality
- Abstract
Background: Combined pancreaticoduodenectomy (PD) and colonic resection may be necessary to achieve an R0 resection of peri-ampullary tumours. The aim of this study was to examine the morbidity and mortality associated with this procedure., Methods: A retrospective cohort study was performed comparing 607 patients who underwent a standard pancreaticoduodenectomy (S-PD) to 28 patients who had a concomitant colon resection and PD (PD-colon) over a 10-year period at an academic centre., Results: Patients in the PD-colon group were more likely to have received neoadjuvant chemotherapy ± radiation (3/28, 11% versus 14/607, 2%, P = 0.024). Operative time was also longer (530 versus 410 min, P < 0.001) and they were more likely to have had portal vein resections (9/28, 32% versus 76/607, 13%, P = 0.007). There was no difference in the intra-operative blood loss, length of stay, or overall complication rates. The PD-colon group had a higher rate of severe post-operative bleeding (4/28, 11% versus 8/607, 1%, P = 0.002). The post-operative mortality rates for the PD-colon and PD groups were 2/28 (7%) and 8/607 (1%), respectively (P = 0.068)., Conclusions: PD-colon has an acceptable risk of peri-operative morbidity compared with S-PD in well-selected patients., (© 2014 International Hepato-Pancreato-Biliary Association.)
- Published
- 2014
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