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Combined pancreaticoduodenectomy and colon resection for locally advanced peri-ampullary tumours: analysis of peri-operative morbidity and mortality.
- Source :
-
HPB : the official journal of the International Hepato Pancreato Biliary Association [HPB (Oxford)] 2014 Sep; Vol. 16 (9), pp. 797-800. Date of Electronic Publication: 2014 Apr 18. - Publication Year :
- 2014
-
Abstract
- Background: Combined pancreaticoduodenectomy (PD) and colonic resection may be necessary to achieve an R0 resection of peri-ampullary tumours. The aim of this study was to examine the morbidity and mortality associated with this procedure.<br />Methods: A retrospective cohort study was performed comparing 607 patients who underwent a standard pancreaticoduodenectomy (S-PD) to 28 patients who had a concomitant colon resection and PD (PD-colon) over a 10-year period at an academic centre.<br />Results: Patients in the PD-colon group were more likely to have received neoadjuvant chemotherapy ± radiation (3/28, 11% versus 14/607, 2%, P = 0.024). Operative time was also longer (530 versus 410 min, P < 0.001) and they were more likely to have had portal vein resections (9/28, 32% versus 76/607, 13%, P = 0.007). There was no difference in the intra-operative blood loss, length of stay, or overall complication rates. The PD-colon group had a higher rate of severe post-operative bleeding (4/28, 11% versus 8/607, 1%, P = 0.002). The post-operative mortality rates for the PD-colon and PD groups were 2/28 (7%) and 8/607 (1%), respectively (P = 0.068).<br />Conclusions: PD-colon has an acceptable risk of peri-operative morbidity compared with S-PD in well-selected patients.<br /> (© 2014 International Hepato-Pancreato-Biliary Association.)
- Subjects :
- Academic Medical Centers
Adult
Aged
Blood Loss, Surgical
Chemotherapy, Adjuvant
Digestive System Neoplasms mortality
Digestive System Neoplasms pathology
Female
Hospitals, High-Volume
Humans
Length of Stay
Male
Middle Aged
Neoadjuvant Therapy
Ontario
Operative Time
Postoperative Hemorrhage etiology
Postoperative Hemorrhage mortality
Retrospective Studies
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
Young Adult
Colectomy adverse effects
Colectomy mortality
Digestive System Neoplasms surgery
Pancreaticoduodenectomy adverse effects
Pancreaticoduodenectomy mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1477-2574
- Volume :
- 16
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- HPB : the official journal of the International Hepato Pancreato Biliary Association
- Publication Type :
- Academic Journal
- Accession number :
- 24750414
- Full Text :
- https://doi.org/10.1111/hpb.12263