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1. The three facets of the SARS-CoV-2 pandemic during the first two waves in the northern, central, and southern Italy

Author

Buscemi, Silvio, Davoli, Chiara, Trecarichi, Enrico Maria, Morrone, Helen Linda, Tassone, Bruno, Buscemi, Carola, Randazzo, Cristiana, Barile, Anna Maria, Colombrita, Piero, Soresi, Maurizio, Giannitrapani, Lydia, Cascio, Antonio, Scichilone, Nicola, Cottone, Carlo, Sbraccia, Paolo, Guglielmi, Valeria, Leonetti, Frida, Malavazos, Alexis Elias, Basilico, Sara, Carruba, Michele, Santini, Ferruccio, Antonelli, Alessandro, Viola, Nicola, Romano, Marcello, Cesana, Bruno Mario, and Torti, Carlo

Published
2023
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2. Publisher Correction: Lessons learned and implications of early therapies for coronavirus disease in a territorial service centre in the Calabria region: a retrospective study

Author

Scaglione, Vincenzo, Rotundo, Salvatore, Marascio, Nadia, De Marco, Carmela, Lionello, Rosaria, Veneziano, Claudia, Berardelli, Lavinia, Quirino, Angela, Olivadese, Vincenzo, Serapide, Francesca, Tassone, Bruno, Morrone, Helen Linda, Davoli, Chiara, La Gamba, Valentina, Bruni, Andrea, Cesana, Bruno Mario, Matera, Giovanni, Russo, Alessandro, Costanzo, Francesco Saverio, Viglietto, Giuseppe, Trecarichi, Enrico Maria, and Torti, Carlo

Published
2022
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3. Lessons learned and implications of early therapies for coronavirus disease in a territorial service centre in the Calabria region: a retrospective study

Author

Scaglione, Vincenzo, Rotundo, Salvatore, Marascio, Nadia, De Marco, Carmela, Lionello, Rosaria, Veneziano, Claudia, Berardelli, Lavinia, Quirino, Angela, Olivadese, Vincenzo, Serapide, Francesca, Tassone, Bruno, Morrone, Helen Linda, Davoli, Chiara, La Gamba, Valentina, Bruni, Andrea, Cesana, Bruno Mario, Matera, Giovanni, Russo, Alessandro, Costanzo, Francesco Saverio, Viglietto, Giuseppe, Trecarichi, Enrico Maria, and Torti, Carlo

Published
2022
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5. La retroversione degli utili

Author

A cura di: CASSANO GIUSEPPE, FRANCESCHELLI VINCENZO, TASSONE BRUNO, Moro Visconti, Roberto, moro visconti, roberto (ORCID:0000-0002-3458-5161), A cura di: CASSANO GIUSEPPE, FRANCESCHELLI VINCENZO, TASSONE BRUNO, Moro Visconti, Roberto, and moro visconti, roberto (ORCID:0000-0002-3458-5161)

Abstract

Nel diritto industriale, la retroversione degli utili del contraffattore si riferisce alla pratica di restituzione dei profitti ottenuti illegalmente da un contraffattore al titolare del marchio originale. In pratica, quando un'impresa produce e commercializza prodotti contraffatti di un marchio registrato, consegue profitti che sarebbero spettati al titolare del marchio originale. La retroversione degli utili prevede quindi che il contraffattore sia obbligato a restituire questi indebiti profitti al titolare del marchio originale come risarcimento per il danno subito.

Published
2023

8. Interleukin-62/lymphocyte as a proposed predictive index for COVID-19 patients treated with monoclonal antibodies.

Author

Rotundo, Salvatore, Borelli, Massimo, Scaglione, Vincenzo, Lionello, Rosaria, Biamonte, Flavia, Olivadese, Vincenzo, Quirino, Angela, Morrone, Helen Linda, Matera, Giovanni, Costanzo, Francesco Saverio, Russo, Alessandro, Trecarichi, Enrico Maria, Torti, Carlo, IDTM UMG COVID-19 Group, Serapide, Francesca, Tassone, Bruno, Fusco, Paolo, Davoli, Chiara, La Gamba, Valentina, and Berardelli, Lavinia

Subjects
COVID-19, MONOCLONAL antibodies, CONVENIENCE sampling (Statistics), ASYMPTOMATIC patients, DISEASE progression
Abstract

In a convenience sample of 93 patients treated with monoclonal antibodies (moAbs) against SARS-CoV-2, the interleukin-62/lymphocyte count ratio (IL-62/LC) was able to predict clinical worsening both in early stages of COVID-19 and in oxygen-requiring patients. Moreover, we analysed 18 most at-risk patients with asymptomatic or mild disease treated with both moAbs and antiviral treatment and found that only 2 had clinical progression, while patients with a similar risk were reported to have an unfavourable outcome in most cases from recent data. In only one of our 18 patients, clinical progression was attributable to COVID-19, and in the other cases, clinical progression was observed despite IL-62/LC being above the risk cut-off. In conclusion, IL-62/LC may be a valuable method to identify patients requiring more aggressive treatments both in earlier and later stages of the disease; however, most at-risk patients can be protected from clinical worsening by combining moAbs and antivirals, even if levels of the IL-62/LC biomarker are lower than the risk cut-off. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Lessons learned and implications of early therapies for coronavirus disease in a territorial service center in the Calabria region

Author

Scaglione, Vincenzo, primary, Rotundo, Salvatore, additional, Marascio, Nadia, additional, De Marco, Carmela, additional, Lionello, Rosaria, additional, Veneziano, Claudia, additional, Berardelli, Lavinia, additional, Quirino, Angela, additional, Olivadese, Vincenzo, additional, Serapide, Francesca, additional, Tassone, Bruno, additional, Morrone, Helen Linda, additional, Davoli, Chiara, additional, Gamba, Valentina La, additional, Bruni, Andrea, additional, Cesana, Bruno Mario, additional, Matera, Giovanni, additional, Russo, Alessandro, additional, Costanzo, Francesco Saverio, additional, Viglietto, Giuseppe, additional, Trecarichi, Enrico Maria, additional, and Torti, Carlo, additional

Published
2022
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11. Clinical Characteristics and Outcome of Hospitalized COVID-19 Patients Treated with Standard Dose of Dexamethasone or High Dose of Methylprednisolone

Author

Russo, Alessandro, primary, Davoli, Chiara, additional, Borrazzo, Cristian, additional, Olivadese, Vincenzo, additional, Ceccarelli, Giancarlo, additional, Fusco, Paolo, additional, Lazzaro, Alessandro, additional, Lionello, Rosaria, additional, Ricchio, Marco, additional, Serapide, Francesca, additional, Tassone, Bruno, additional, Gentilini Cacciola, Elio, additional, Mastroianni, Claudio Maria, additional, Torti, Carlo, additional, d’Ettorre, Gabriella, additional, and Trecarichi, Enrico Maria, additional

Published
2022
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14. Additional file 2 of Lessons learned and implications of early therapies for coronavirus disease in a territorial service centre in the Calabria region: a retrospective study

Author

Scaglione, Vincenzo, Rotundo, Salvatore, Marascio, Nadia, De Marco, Carmela, Lionello, Rosaria, Veneziano, Claudia, Berardelli, Lavinia, Quirino, Angela, Olivadese, Vincenzo, Serapide, Francesca, Tassone, Bruno, Morrone, Helen Linda, Davoli, Chiara, La Gamba, Valentina, Bruni, Andrea, Cesana, Bruno Mario, Matera, Giovanni, Russo, Alessandro, Costanzo, Francesco Saverio, Viglietto, Giuseppe, Trecarichi, Enrico Maria, and Torti, Carlo

Abstract

Additional file 2: Table S2. Complete list of mutations identified in the SARS-CoV-2 genomes from patients described.

Published
2022
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15. Additional file 1 of Lessons learned and implications of early therapies for coronavirus disease in a territorial service centre in the Calabria region: a retrospective study

Author

Scaglione, Vincenzo, Rotundo, Salvatore, Marascio, Nadia, De Marco, Carmela, Lionello, Rosaria, Veneziano, Claudia, Berardelli, Lavinia, Quirino, Angela, Olivadese, Vincenzo, Serapide, Francesca, Tassone, Bruno, Morrone, Helen Linda, Davoli, Chiara, La Gamba, Valentina, Bruni, Andrea, Cesana, Bruno Mario, Matera, Giovanni, Russo, Alessandro, Costanzo, Francesco Saverio, Viglietto, Giuseppe, Trecarichi, Enrico Maria, and Torti, Carlo

Abstract

Additional file 1: Table S1. Metrics of Next Generation Sequencing reported for each viral isolate.

Published
2022
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22. Módulos de demazure para álgebras de Kac-Moody afim

Author

Tassone, Bruno (Bruno Leonardo Tassone da Silva), Universidade Federal do Paraná. Setor de Ciências Exatas. Programa de Pós-Graduação em Matemática, and Brito, Matheus Batagini, 1985

Subjects
Matemática, Modulos (Algebra)
Abstract

Orientador: Prof. Dr. Matheus Batagini Brito Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências Exatas, Programa de Pós-Graduação em Matemática. Defesa : Curitiba, 25/02/2021 Inclui referências: p. 70-71 Resumo: Essa dissertação aborda a teoria de representações para álgebras de correntes associada a uma álgebra de Kac-Moody de tipo finito, com particular interesse em módulos de Weyl e Demazure. Além de desenvolver toda a teoria necessária para o estudo do tema supracitado, são mostradas conexões entre módulos de Weyl e módulos de Demazure g-estáveis. Através de resultados já conhecidos é apresentado um novo conjunto de relações definidoras para módulos de Demazure de nível um que são g-estáveis. Parte destes resultados são então aplicados no estudo de produtos de fusão destas classes de representações. Palavras-chave: Álgebras de correntes; Teoria de representações; Módulos de Weyl; Módulos de Demazure. Abstract: This dissertation addresses the representation theory for current algebras associated with a finite type Kac-Moody algebra, with a particular interest in Weyl and Demazure modules. In addition to developing all the necessary theories for the study of the aforementioned subject, connections between Weyl modules and Demazure g-stable modules are shown. Through known results, a new set of defining relations is provided for g-stable level one Demazure modules. Part of these results is then applied to the study of fusion products for these classes of representations. Keywords: Current algebras; Representation theory; Weyl modules; Demazure modules.

Published
2021

23. Characteristics, Management, and Outcomes of Elderly Patients with Diabetes in a Covid-19 Unit: Lessons Learned from a Pilot Study

Author

Ricchio, Marco, primary, Tassone, Bruno, additional, Pelle, Maria Chiara, additional, Mazzitelli, Maria, additional, Serapide, Francesca, additional, Fusco, Paolo, additional, Lionello, Rosaria, additional, Cancelliere, Anna, additional, Procopio, Giada, additional, Lio, Elena, additional, Trecarichi, Enrico Maria, additional, Torti, Carlo, additional, and Irace, Concetta, additional

Published
2021
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25. Clinical characteristics and predictors of mortality associated with COVID-19 in elderly patients from a long-term care facility

Author

Trecarichi, Enrico Maria, Mazzitelli, Maria, Serapide, Francesca, Pelle, Maria Chiara, Tassone, Bruno, Arrighi, Eugenio, Perri, Graziella, Fusco, Paolo, Scaglione, Vincenzo, Davoli, Chiara, Lionello, Rosaria, La Gamba, Valentina, Marrazzo, Giuseppina, Busceti, Maria Teresa, Giudice, Amerigo, Ricchio, Marco, Cancelliere, Anna, Lio, Elena, Procopio, Giada, Costanzo, Francesco Saverio, Foti, Daniela Patrizia, Matera, Giovanni, Torti, Carlo, Laganà, Domenico, Petullà, Maria, Bertucci, Bernardo, Quirino, Angela, Barreca, Giorgio Settimo, Giancotti, Aida, Gallo, Luigia, Lamberti, Angelo, Liberto, Maria Carla, Marascio, Nadia, De Francesco, Adele Emanuela, and IDTM UMG COVID-19 Group

Subjects
0301 basic medicine, Male, medicine.medical_specialty, China, Epidemiology, Article, COVID-19, Infectious diseases, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Lymphopenia, Pandemic, medicine, Humans, 030212 general & internal medicine, Hospital Mortality, Aged, Aged, 80 and over, Multidisciplinary, Hypernatremia, Proportional hazards model, business.industry, Interleukin-6, SARS-CoV-2, Mortality rate, Outbreak, medicine.disease, Long-Term Care, Nursing Homes, Hospitalization, Long-term care, 030104 developmental biology, Cardiovascular Diseases, Cohort, Female, business, Cytokine Release Syndrome, Cohort study
Abstract

Since December 2019, coronavirus disease 2019 (COVID-19) pandemic has spread from China all over the world and many COVID-19 outbreaks have been reported in long-term care facilities (LCTF). However, data on clinical characteristics and prognostic factors in such settings are scarce. We conducted a retrospective, observational cohort study to assess clinical characteristics and baseline predictors of mortality of COVID-19 patients hospitalized after an outbreak of SARS-CoV-2 infection in a LTCF. A total of 50 patients were included. Mean age was 80 years (SD, 12 years), and 24/50 (57.1%) patients were males. The overall in-hospital mortality rate was 32%. At Cox regression analysis, significant predictors of in-hospital mortality were: hypernatremia (HR 9.12), lymphocyte count

Published
2020

26. Spontaneous and severe haematomas in patients with COVID-19 on low-molecular-weight heparin for paroxysmal atrial fibrillation

Author

Mazzitelli, Maria, Serapide, Francesca, Tassone, Bruno, Laganà, Domenico, Trecarichi, Enrico Maria, and Torti, Carlo

Subjects
Haematoma, VTE prophylaxis, SARS-CoV-2, Heparin, lcsh:RC633-647.5, Thromboembolism, COVID-19, Thrombosis, lcsh:Diseases of the blood and blood-forming organs, Letter to the Editor, Spontaneous bleeding, bleeding
Abstract

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Published
2020

27. Food Rights and the Protection of Creative Dishes in a Comparative Perspective

Author

Barbone, Marco and Tassone, Bruno

Abstract

In molti sistemi la ricetta, intesa come combinazione di ingredienti usati per preparare un piatto, si ritiene non possa ricevere tutela, salvo il caso in cui sia trasposta in un testo scritto munito del carattere creativo. Dopo aver descritto alcuni aspetti del fenomeno della c.d. “food-art”, gli autori esplorano la possibilità di dare protezione al piatto sotto il profilo della forma secondo il diritto d’autore nei Paesi di Civil Law e Common Law, chiedendosi quanto le diverse soluzioni siano legate ai modelli che le due “famiglie” approntano con riguardo alla proprietà intellettuale in generale., Cibo e diritto. Una prospettiva comparata. Volume 2

Published
2020
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28. Pattern of comorbidities and 1-year mortality in elderly patients with COPD hospitalized in internal medicine wards: data from the RePoSI Registry

Author

Argano, Christiano, Scichilone, Nicola, Natoli, Giuseppe, Nobili, Alessandro, Corazza, Gino Roberto, Mannucci, Pier Mannuccio, Perticone, Francesco, Corrao, Salvatore, Pietrangelo, Antonello, Licata, Giuseppe, Violi, Francesco, Marengoni, Alessandra, Salerno, Francesco, Cesari, Matteo, Tettamanti, Mauro, Pasina, Luca, Franchi, Carlotta, Miglio, Gabriella, Cortesi, Laura, Ardoino, Ilaria, Novella, Alessio, Prisco, Domenico, Silvestri, Elena, Emmi, Giacomo, Bettiol, Alessandra, Caterina, Cenci, Biolo, Gianni, Zanetti, Michela, Guadagni, Martina, Zaccari, Michele, Chiuch, Massimiliano, Vanoli, Massimo, Grignani, Giulia, Pulixi, Edoardo Alessandro, Bernardi, Mauro, Bassi, Silvia Li, Santi, Luca, Zaccherini, Giacomo, Lupattelli, Graziana, Mannarino, Elmo, Bianconi, Vanessa, Paciullo, Francesco, Alcidi, Riccardo, Nuti, Ranuccio, Valenti, Roberto, Ruvio, Martina, Cappelli, Silvia, Palazzuoli, Alberto, Girelli, Domenico, Busti, Fabiana, Marchi, Giacomo, Barbagallo, Mario, Dominguez, Ligia, Cocita, Floriana, Beneduce, Vincenza, Plances, Lidia, Mularo, Salvatore, Raspanti, Massimo, Cavallaro, Federica, Zoli, Marco, Lazzari, Ilaria, Brunori, Mattia, Fabbri, Elisa, Magalotti, Donatella, Arnò, Raffaella, Pasini, Franco Laghi, Capecchi, Pier Leopoldo, Palasciano, Giuseppe, Modeo, Maria Ester, Di Gennaro, Carla, Cappellini, Maria Domenica, Maira, Diletta, Di Stefano, Valeria, Fabio, Giovanna, Seghezzi, Sonia, Mancarella, Marta, De Amicis, Margherita Migone, De Luca, Giacomo, Scaramellini, Natalia, Rossi, Paolo Dionigi, Damanti, Sarah, Clerici, Marta, Conti, Federica, Bonini, Giulia, Ottolini, Barbara Brignolo, Di Sabatino, Antonio, Miceli, Emanuela, Lenti, Marco Vincenzo, Pisati, Martina, Dominioni, Costanza Caccia, Murialdo, Giovanni, Marra, Alessio, Cattaneo, Federico, Pontremoli, Roberto, Beccati, Valentina, Nobili, Giulia, Secchi, Maria Beatrice, Ghelfi, Davide, Anastasio, Luigi, Sofia, Lucia, Carbone, Maria, Cipollone, Francesco, Guagnano, Maria Teresa, Valeriani, Emanuele, Rossi, Ilaria, Mancuso, Gerardo, Calipari, Daniela, Bartone, Mosè, Delitala, Giuseppe, Berria, Maria, Pes, Chiara, Delitala, Alessandro, Muscaritoli, Maurizio, Molfino, Alessio, Petrillo, Enrico, Zuccalà, Giuseppe, D’Aurizio, Gabriella, Romanelli, Giuseppe, Zucchelli, Alberto, Manzoni, Francesca, Volpini, Andrea, Picardi, Antonio, Gentilucci, Umberto Vespasiani, Gallo, Paolo, Dell’Unto, Chiara, Annoni, Giorgio, Corsi, Maurizio, Bellelli, Giuseppe, Zazzetta, Sara, Mazzola, Paolo, Szabo, Hajnalka, Bonfanti, Alessandra, Arturi, Franco, Succurro, Elena, Rubino, Mariangela, Tassone, Bruno, Sesti, Giorgio, Serra, Maria Grazia, Bleve, Maria Antonietta, Gasbarrone, Laura, Sajeva, Maria Rosaria, Brucato, Antonio, Ghidoni, Silvia, Fabris, Fabrizio, Bertozzi, Irene, Bogoni, Giulia, Rabuini, Maria Victoria, Cosi, Elisabetta, Scarinzi, Paolo, Amabile, Annalisa, Omenetto, Elisabetta, Prandini, Tancredi, Manfredini, Roberto, Fabbian, Fabio, Boari, Benedetta, De Giorgi, Alfredo, Tiseo, Ruana, De Giorgio, Roberto, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Borghi, Claudio, Strocchi, Enrico, Ianniello, Eugenia, Soldati, Mario, Sabbà, Carlo, Vella, Francesco Saverio, Suppressa, Patrizia, Schilardi, Andrea, Loparco, Francesca, De Vincenzo, Giovanni Michele, Comitangelo, Alessio, Amoruso, Emanuele, Fenoglio, Luigi, Falcetta, Andrea, Bracco, Christian, Fracanzani Silvia Fargion, Anna L., Tiraboschi, Silvia, Cespiati, Annalisa, Oberti, Giovanna, Sigon, Giordano, Peyvandi, Flora, Rossio, Raffaella, Ferrari, Barbara, Colombo, Giulia, Agosti, Pasquale, Monzani, Valter, Savojardo, Valeria, Folli, Christian, Ceriani, Giuliana, Pallini, Giada, Dallegri, Franco, Ottonello, Luciano, Liberale, Luca, Caserza, Lara, Salam, Kassem, Liberato, Nicola Lucio, Tognin, Tiziana, Bianchi, Giovanni Battista, Giaquinto, Sabrina, Purrello, Francesco, Di Pino, Antonino, Piro, Salvatore, Rozzini, Renzo, Falanga, Lina, Spazzini, Elena, Ferrandina, Camillo, Montrucchio, Giuseppe, Petitti, Paolo, Peasso, Paolo, Favale, Edoardo, Poletto, Cesare, Salmi, Raffaella, Gaudenzi, Piergiorgio, Perri, Ludovica, Landolfi, Raffaele, Montalto, Massimo, Mirijello, Antonio, Guasti, Luigina, Castiglioni, Luana, Maresca, Andrea, Squizzato, Alessandro, Campiotti, Leonardo, Grossi, Alessandra, Bertolotti, Marco, Mussi, Chiara, Lancellotti, Giulia, Libbra, Maria Vittoria, Dondi, Giulia, Pellegrini, Elisa, Carulli, Lucia, Galassi, Matteo, Grassi, Yasmine, Perticone, Maria, Battaglia, Rosa, FIlice, Marco, Maio, Raffaele, Stanghellini, Vincenzo, Ruggeri, Eugenio, del Vecchio, Sara, Salvi, Andrea, Leonardi, Roberto, Damiani, Giampaolo, Capeci, William, Gabrielli, Armando, Mattioli, Massimo, Martino, Giuseppe Pio, Biondi, Lorenzo, Pettinari, Pietro, Ghio, Riccardo, Col, Anna Dal, Minisola, Salvatore, Colangelo, Luciano, Cilli, Mirella, Labbadia, Giancarlo, Afeltra, Antonella, Marigliano, Benedetta, Pipita, Maria Elena, Castellino, Pietro, Zanoli, Luca, Pignataro, Samuele, Gennaro, Alfio, Blanco, Julien, Saracco, Valter, Fogliati, Marisa, Bussolino, Carlo, Mete, Francesca, Gino, Miriam, Cittadini, Antonio, Vigorito, Carlo, Arcopinto, Michele, Salzano, Andrea, Bobbio, Emanuele, Marra, Alberto Maria, Sirico, Domenico, Moreo, Guido, Gasparini, Francesca, Prolo, Silvia, Pina, Gloria, Ballestrero, Alberto, Ferrando, Fabio, Berra, Sergio, Dassi, Simonetta, Nava, Maria Cristina, Graziella, Bruno, Baldassarre, Stefano, Fragapani, Salvatore, Gruden, Gabriella, Galanti, Giorgio, Mascherini, Gabriele, Petri, Cristian, Stefani, Laura, Girino, Margherita, Piccinelli, Valeria, Nasso, Francesco, Gioffrè, Vincenza, Pasquale, Maria, Scattolin, Giuseppe, Martinelli, Sergio, Turrin, Mauro, Sechi, Leonardo, Catena, Cristina, Colussi, Gianluca, Passariello, Nicola, Rinaldi, Luca, Berti, Franco, Famularo, Giuseppe, Tarsitani, Patrizia, Castello, Roberto, Pasino, Michela, Ceda, Gian Paolo, Maggio, Marcello Giuseppe, Morganti, Simonetta, Artoni, Andrea, Del Giacco, Stefano, Firinu, Davide, Losa, Francesca, Paoletti, Giovanni, Costanzo, Giulia, Montalto, Giuseppe, Licata, Anna, Malerba, Valentina, Montalto, Filippo Alessandro, Lasco, Antonino, Basile, Giorgio, Catalano, Antonino, Malatino, Lorenzo, Stancanelli, Benedetta, Terranova, Valentina, Di Marca, Salvatore, Di Quattro, Rosario, La Malfa, Lara, Caruso, Rossella, Mecocci, Patrizia, Ruggiero, Carmelinda, Boccardi, Virginia, Meschi, Tiziana, Lauretani, Fulvio, Ticinesi, Andrea, Nouvenne, Antonio, Minuz, Pietro, Fondrieschi, Luigi, Pirisi, Mario, Fra, Gian Paolo, Sola, Daniele, Porta, Massimo, Riva, Piero, Quadri, Roberto, Larovere, Erica, Novelli, Marco, Scanzi, Giorgio, Mengoli, Caterina, Provini, Stella, Ricevuti, Laura, Simeone, Emilio, Scurti, Rosa, Tolloso, Fabio, Tarquini, Roberto, Valoriani, Alice, Dolenti, Silvia, Vannini, Giulia, Tedeschi, Alberto, Trotta, Lucia, Volpi, Riccardo, Bocchi, Pietro, Vignali, Alessandro, Harari, Sergio, Lonati, Chiara, Cattaneo, Mara, Napoli, Federico, Argano, Christiano, Scichilone, Nicola, Natoli, Giuseppe, Nobili, Alessandro, Corazza, Gino Roberto, Mannucci, Pier Mannuccio, Perticone, Francesco, Corrao, Salvatore, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Argano, C., Scichilone, N., Natoli, G., Nobili, A., Corazza, G. R., Mannucci, P. M., Perticone, F., Corrao, S., Pietrangelo, A., Licata, G., Violi, F., Marengoni, A., Salerno, F., Cesari, M., Tettamanti, M., Pasina, L., Franchi, C., Miglio, G., Cortesi, L., Ardoino, I., Novella, A., Prisco, D., Silvestri, E., Emmi, G., Bettiol, A., Caterina, C., Biolo, G., Zanetti, M., Guadagni, M., Zaccari, M., Chiuch, M., Vanoli, M., Grignani, G., Pulixi, E. A., Bernardi, M., Bassi, S. L., Santi, L., Zaccherini, G., Lupattelli, G., Mannarino, E., Bianconi, V., Paciullo, F., Alcidi, R., Nuti, R., Valenti, R., Ruvio, M., Cappelli, S., Palazzuoli, A., Girelli, D., Busti, F., Marchi, G., Barbagallo, M., Dominguez, L., Cocita, F., Beneduce, V., Plances, L., Mularo, S., Raspanti, M., Cavallaro, F., Zoli, M., Lazzari, I., Brunori, M., Fabbri, E., Magalotti, D., Arno, R., Pasini, F. L., Capecchi, P. L., Palasciano, G., Modeo, M. E., Di Gennaro, C., Cappellini, M. D., Maira, D., Di Stefano, V., Fabio, G., Seghezzi, S., Mancarella, M., De Amicis, M. M., De Luca, G., Scaramellini, N., Rossi, P. D., Damanti, S., Clerici, M., Conti, F., Bonini, G., Ottolini, B. B., Di Sabatino, A., Miceli, E., Lenti, M. V., Pisati, M., Dominioni, C. C., Murialdo, G., Marra, A., Cattaneo, F., Pontremoli, R., Beccati, V., Nobili, G., Secchi, M. B., Ghelfi, D., Anastasio, L., Sofia, L., Carbone, M., Cipollone, F., Guagnano, M. T., Valeriani, E., Rossi, I., Mancuso, G., Calipari, D., Bartone, M., Delitala, G., Berria, M., Pes, C., Delitala, A., Muscaritoli, M., Molfino, A., Petrillo, E., Zuccala, G., D'Aurizio, G., Romanelli, G., Zucchelli, A., Manzoni, F., Volpini, A., Picardi, A., Gentilucci, U. V., Gallo, P., Dell'Unto, C., Annoni, G., Corsi, M., Bellelli, G., Zazzetta, S., Mazzola, P., Szabo, H., Bonfanti, A., Arturi, F., Succurro, E., Rubino, M., Tassone, B., Sesti, G., Serra, M. G., Bleve, M. A., Gasbarrone, L., Sajeva, M. R., Brucato, A., Ghidoni, S., Fabris, F., Bertozzi, I., Bogoni, G., Rabuini, M. V., Cosi, E., Scarinzi, P., Amabile, A., Omenetto, E., Prandini, T., Manfredini, R., Fabbian, F., Boari, B., De Giorgi, A., Tiseo, R., De Giorgio, R., Paolisso, G., Rizzo, M. R., Borghi, C., Strocchi, E., Ianniello, E., Soldati, M., Sabba, C., Vella, F. S., Suppressa, P., Schilardi, A., Loparco, F., De Vincenzo, G. M., Comitangelo, A., Amoruso, E., Fenoglio, L., Falcetta, A., Bracco, C., Fracanzani Silvia Fargion, A. L., Tiraboschi, S., Cespiati, A., Oberti, G., Sigon, G., Peyvandi, F., Rossio, R., Ferrari, B., Colombo, G., Agosti, P., Monzani, V., Savojardo, V., Folli, C., Ceriani, G., Pallini, G., Dallegri, F., Ottonello, L., Liberale, L., Caserza, L., Salam, K., Liberato, N. L., Tognin, T., Bianchi, G. 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Sesti, G, Serra, M, Bleve, M, Gasbarrone, L, Sajeva, M, Brucato, A, Ghidoni, S, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Cosi, E, Scarinzi, P, Amabile, A, Omenetto, E, Prandini, T, Manfredini, R, Fabbian, F, Boari, B, De Giorgi, A, Tiseo, R, De Giorgio, R, Paolisso, G, Rizzo, M, Borghi, C, Strocchi, E, Ianniello, E, Soldati, M, Sabba, C, Vella, F, Suppressa, P, Schilardi, A, Loparco, F, De Vincenzo, G, Comitangelo, A, Amoruso, E, Fenoglio, L, Falcetta, A, Bracco, C, Fracanzani Silvia Fargion, A, Tiraboschi, S, Cespiati, A, Oberti, G, Sigon, G, Peyvandi, F, Rossio, R, Ferrari, B, Colombo, G, Agosti, P, Monzani, V, Savojardo, V, Folli, C, Ceriani, G, Pallini, G, Dallegri, F, Ottonello, L, Liberale, L, Caserza, L, Salam, K, Liberato, N, Tognin, T, Bianchi, G, Giaquinto, S, Purrello, F, Di Pino, A, Piro, S, Rozzini, R, Falanga, L, Spazzini, E, Ferrandina, C, Montrucchio, G, Petitti, P, Peasso, P, Favale, E, Poletto, C, Salmi, R, Gaudenzi, P, Perri, L, Landolfi, R, Montalto, M, 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S, Turrin, M, Sechi, L, Catena, C, Colussi, G, Passariello, N, Rinaldi, L, Berti, F, Famularo, G, Tarsitani, P, Castello, R, Pasino, M, Ceda, G, Maggio, M, Morganti, S, Artoni, A, Del Giacco, S, Firinu, D, Losa, F, Paoletti, G, Costanzo, G, Montalto, G, Licata, A, Malerba, V, Montalto, F, Lasco, A, Basile, G, Catalano, A, Malatino, L, Stancanelli, B, Terranova, V, Di Marca, S, Di Quattro, R, La Malfa, L, Caruso, R, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Lauretani, F, Ticinesi, A, Nouvenne, A, Minuz, P, Fondrieschi, L, Pirisi, M, Fra, G, Sola, D, Porta, M, Riva, P, Quadri, R, Larovere, E, Novelli, M, Scanzi, G, Mengoli, C, Provini, S, Ricevuti, L, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Tedeschi, A, Trotta, L, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Cattaneo, M, Napoli, F, Argano C., Scichilone N., Natoli G., Nobili A., Corazza G.R., Mannucci P.M., Perticone F., Corrao S., Pietrangelo A., Licata G., Violi F., Marengoni A., Salerno F., Cesari M., Tettamanti M., Pasina L., Franchi C., Miglio G., Cortesi L., Ardoino I., Novella A., Prisco D., Silvestri E., Emmi G., Bettiol A., Caterina C., Biolo G., Zanetti M., Guadagni M., Zaccari M., Chiuch M., Vanoli M., Grignani G., Pulixi E.A., Bernardi M., Bassi S.L., Santi L., Zaccherini G., Lupattelli G., Mannarino E., Bianconi V., Paciullo F., Alcidi R., Nuti R., Valenti R., Ruvio M., Cappelli S., Palazzuoli A., Girelli D., Busti F., Marchi G., Barbagallo M., Dominguez L., Cocita F., Beneduce V., Plances L., Mularo S., Raspanti M., Cavallaro F., Zoli M., Lazzari I., Brunori M., Fabbri E., Magalotti D., Arno R., Pasini F.L., Capecchi P.L., Palasciano G., Modeo M.E., Di Gennaro C., Cappellini M.D., Maira D., Di Stefano V., Fabio G., Seghezzi S., Mancarella M., De Amicis M.M., De Luca G., Scaramellini N., Rossi P.D., Damanti S., Clerici M., Conti F., Bonini G., Ottolini B.B., Di Sabatino A., Miceli E., Lenti M.V., Pisati M., Dominioni C.C., Murialdo G., Marra A., Cattaneo F., Pontremoli R., Beccati V., Nobili G., Secchi M.B., Ghelfi D., Anastasio L., Sofia L., Carbone M., Cipollone F., Guagnano M.T., Valeriani E., Rossi I., Mancuso G., Calipari D., Bartone M., Delitala G., Berria M., Pes C., Delitala A., Muscaritoli M., Molfino A., Petrillo E., Zuccala G., D'Aurizio G., Romanelli G., Zucchelli A., Manzoni F., Volpini A., Picardi A., Gentilucci U.V., Gallo P., Dell'Unto C., Annoni G., Corsi M., Bellelli G., Zazzetta S., Mazzola P., Szabo H., Bonfanti A., Arturi F., Succurro E., Rubino M., Tassone B., Sesti G., Serra M.G., Bleve M.A., Gasbarrone L., Sajeva M.R., Brucato A., Ghidoni S., Fabris F., Bertozzi I., Bogoni G., Rabuini M.V., Cosi E., Scarinzi P., Amabile A., Omenetto E., Prandini T., Manfredini R., Fabbian F., Boari B., De Giorgi A., Tiseo R., De Giorgio R., Paolisso G., Rizzo M.R., Borghi C., Strocchi E., Ianniello E., Soldati M., Sabba C., Vella F.S., Suppressa P., Schilardi A., Loparco F., De Vincenzo G.M., Comitangelo A., Amoruso E., Fenoglio L., Falcetta A., Bracco C., Fracanzani Silvia Fargion A.L., Tiraboschi S., Cespiati A., Oberti G., Sigon G., Peyvandi F., Rossio R., Ferrari B., Colombo G., Agosti P., Monzani V., Savojardo V., Folli C., Ceriani G., Pallini G., Dallegri F., Ottonello L., Liberale L., Caserza L., Salam K., Liberato N.L., Tognin T., Bianchi G.B., Giaquinto S., Purrello F., Di Pino A., Piro S., Rozzini R., Falanga L., Spazzini E., Ferrandina C., Montrucchio G., Petitti P., Peasso P., Favale E., Poletto C., Salmi R., Gaudenzi P., Perri L., Landolfi R., Montalto M., Mirijello A., Guasti L., Castiglioni L., Maresca A., Squizzato A., Campiotti L., Grossi A., Bertolotti M., Mussi C., Lancellotti G., Libbra M.V., Dondi G., Pellegrini E., Carulli L., Galassi M., Grassi Y., Perticone M., Battaglia R., FIlice M., Maio R., Stanghellini V., Ruggeri E., del Vecchio S., Salvi A., Leonardi R., Damiani G., Capeci W., Gabrielli A., Mattioli M., Martino G.P., Biondi L., Pettinari P., Ghio R., Col A.D., Minisola S., Colangelo L., Cilli M., Labbadia G., Afeltra A., Marigliano B., Pipita M.E., Castellino P., Zanoli L., Pignataro S., Gennaro A., Blanco J., Saracco V., Fogliati M., Bussolino C., Mete F., Gino M., Cittadini A., Vigorito C., Arcopinto M., Salzano A., Bobbio E., Marra A.M., Sirico D., Moreo G., Gasparini F., Prolo S., Pina G., Ballestrero A., Ferrando F., Berra S., Dassi S., Nava M.C., Graziella B., Baldassarre S., Fragapani S., Gruden G., Galanti G., Mascherini G., Petri C., Stefani L., Girino M., Piccinelli V., Nasso F., Gioffre V., Pasquale M., Scattolin G., Martinelli S., Turrin M., Sechi L., Catena C., Colussi G., Passariello N., Rinaldi L., Berti F., Famularo G., Tarsitani P., Castello R., Pasino M., Ceda G.P., Maggio M.G., Morganti S., Artoni A., Del Giacco S., Firinu D., Losa F., Paoletti G., Costanzo G., Montalto G., Licata A., Malerba V., Montalto F.A., Lasco A., Basile G., Catalano A., Malatino L., Stancanelli B., Terranova V., Di Marca S., Di Quattro R., La Malfa L., Caruso R., Mecocci P., Ruggiero C., Boccardi V., Meschi T., Lauretani F., Ticinesi A., Nouvenne A., Minuz P., Fondrieschi L., Pirisi M., Fra G.P., Sola D., Porta M., Riva P., Quadri R., Larovere E., Novelli M., Scanzi G., Mengoli C., Provini S., Ricevuti L., Simeone E., Scurti R., Tolloso F., Tarquini R., Valoriani A., Dolenti S., Vannini G., Tedeschi A., Trotta L., Volpi R., Bocchi P., Vignali A., Harari S., Lonati C., Cattaneo M., and Napoli F.

Subjects
Male, medicine.medical_specialty, Chronic Obstructive, Cirrhosis, Socio-culturale, Comorbidity, 030204 cardiovascular system & hematology, comorbidities, elderly, Pulmonary Disease, 03 medical and health sciences, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Internal medicine, medicine, 80 and over, COPD, Humans, 030212 general & internal medicine, LS4_4, Registries, Hospital Mortality, COPD, comorbidities, elderly, internal medicine, in-hospital mortality, Depression (differential diagnoses), Cause of death, Aged, Retrospective Studies, 1-year mortality, 3-month mortality, internal medicine, in-hospital mortality, Aged, 80 and over, business.industry, medicine.disease, Im - Original, Female, Internal Medicine, Clinical diagnosis, Cohort, Emergency Medicine, 1-year mortality, 3-month mortality, COPD, comorbidities, elderly, internal medicine, in-hospital mortality, Observational study, business, 1 year mortality
Abstract

Currently, chronic obstructive pulmonary disease (COPD) represents the fourth cause of death worldwide with significant economic burden. Comorbidities increase in number and severity with age and are identified as important determinants that influence the prognosis. In this observational study, we retrospectively analyzed data collected from the RePoSI register. We aimed to investigate comorbidities and outcomes in a cohort of hospitalized elderly patients with the clinical diagnosis of COPD. Socio-demographic, clinical characteristics and laboratory findings were considered. The association between variables and in-hospital, 3-month and 1-year follow-up were analyzed. Among 4696 in-patients, 932 (19.8%) had a diagnosis of COPD. Patients with COPD had more hospitalization, a significant overt cognitive impairment, a clinically significant disability and more depression in comparison with non-COPD subjects. COPD patients took more drugs, both at admission, in-hospital stay, discharge and 3-month and 1-year follow-up. 14 comorbidities were more frequent in COPD patients. Cerebrovascular disease was an independent predictor of in-hospital mortality. At 3-month follow-up, male sex and hepatic cirrhosis were independently associated with mortality. ICS-LABA therapy was predictor of mortality at in-hospital, 3-month and 1-year follow-up. This analysis showed the severity of impact of COPD and its comorbidities in the real life of internal medicine and geriatric wards. Electronic supplementary material The online version of this article (10.1007/s11739-020-02412-1) contains supplementary material, which is available to authorized users.

Published
2020

29. Prognostic relevance of glomerular filtration rate estimation obtained through different equations in hospitalized elderly patients

Author

Gallo, Paolo, De Vincentis, Antonio, Pedone, Claudio, Nobili, Alessandro, Tettamanti, Mauro, Gentilucci, Umberto Vespasiani, Picardi, Antonio, Mannucci, Pier Mannuccio, Incalzi, Raffaele Antonelli, Prisco, Domenico, Silvestri, Elena, Emmi, Giacomo, Bettiol, Alessandra, Caterina, Cenci, Biolo, Gianni, Zanetti, Michela, Guadagni, Martina, Zaccari, Michele, Chiuch, Massimiliano, Vanoli, Massimo, Grignani, Giulia, Pulixi, Edoardo Alessandro, Bernardi, Mauro, Bassi, Silvia Li, Santi, Luca, Zaccherini, Giacomo, Lupattelli, Graziana, Mannarino, Elmo, Bianconi, Vanessa, Paciullo, Francesco, Alcidi, Riccardo, Nuti, Ranuccio, Valenti, Roberto, Ruvio, Martina, Cappelli, Silvia, Palazzuoli, Alberto, Girelli, Domenico, Busti, Fabiana, Marchi, Giacomo, Barbagallo, Mario, Dominguez, Ligia, Cocita, Floriana, Beneduce, Vincenza, Plances, Lidia, Corrao, Salvatore, Natoli, Giuseppe, Mularo, Salvatore, Raspanti, Massimo, Cavallaro, Federica, Zoli, Marco, Lazzari, Ilaria, Brunori, Mattia, Fabbri, Elisa, Magalotti, Donatella, Arno, Raffaella, Pasini, Franco Laghi, Capecchi, Pier Leopoldo, Palasciano, Giuseppe, Modeo, Maria Ester, Di Gennaro, Carla, Cappellini, Maria Domenica, Maira, Diletta, Di Stefano, Valeria, Fabio, Giovanna, Seghezzi, Sonia, Mancarella, Marta, De Amicis, Margherita Migone, De Luca, Giacomo, Scaramellini, Natalia, Cesari, Matteo, Rossi, Paolo Dionigi, Damanti, Sarah, Clerici, Marta, Conti, Federica, Bonini, Giulia, Ottolini, Barbara Brignolo, Di Sabatino, Antonio, Miceli, Emanuela, Lenti, Marco Vincenzo, Pisati, Martina, Dominioni, Costanza Caccia, Murialdo, Giovanni, Marra, Alessio, Cattaneo, Federico, Pontremoli, Roberto, Beccati, Valentina, Nobili, Giulia, Secchi, Maria Beatrice, Ghelfi, Davide, Anastasio, Luigi, Sofia, Lucia, Carbone, Maria, Cipollone, Francesco, Guagnano, Maria Teresa, Valeriani, Emanuele, Rossi, Ilaria, Mancuso, Gerardo, Calipari, Daniela, Bartone, Mose, Delitala, Giuseppe, Berria, Maria, Pes, Chiara, Delitala, Alessandro, Muscaritoli, Maurizio, Molfino, Alessio, Petrillo, Enrico, Zuccala, Giuseppe, D'Aurizio, Gabriella, Romanelli, Giuseppe, Marengoni, Alessandra, Zucchelli, Alberto, Manzoni, Francesca, Volpini, Andrea, Dell'Unto, Chiara, Annoni, Giorgio, Corsi, Maurizio, Bellelli, Giuseppe, Zazzetta, Sara, Mazzola, Paolo, Szabo, Hajnalka, Bonfanti, Alessandra, Arturi, Franco, Succurro, Elena, Rubino, Mariangela, Tassone, Bruno, Sesti, Giorgio, Serra, Maria Grazia, Bleve, Maria Antonietta, Gasbarrone, Laura, Sajeva, Maria Rosaria, Brucato, Antonio, Ghidoni, Silvia, Fabris, Fabrizio, Bertozzi, Irene, Bogoni, Giulia, Rabuini, Maria Victoria, Cosi, Elisabetta, Scarinzi, Paolo, Amabile, Annalisa, Omenetto, Elisabetta, Prandini, Tancredi, Manfredini, Roberto, Fabbian, Fabio, Boari, Benedetta, De Giorgi, Alfredo, Tiseo, Ruana, De Giorgio, Roberto, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Borghi, Claudio, Strocchi, Enrico, Ianniello, Eugenia, Soldati, Mario, Sabba, Carlo, Vella, Francesco Saverio, Suppressa, Patrizia, Agosti, Pasquale, Schilardi, Andrea, Loparco, Francesca, De Vincenzo, Giovanni Michele, Comitangelo, Alessio, Amoruso, Emanuele, Fenoglio, Luigi, Falcetta, Andrea, Bracco, Christian, Fracanzani, Anna L., Fargion, Silvia, Tiraboschi, Silvia, Cespiati, Annalisa, Oberti, Giovanna, Sigon, Giordano, Peyvandi, Flora, Rossio, Raffaella, Ferrari, Barbara, Colombo, Giulia, Monzani, Valter, Savojardo, Valeria, Folli, Christian, Ceriani, Giuliana, Salerno, Francesco, Pallini, Giada, Dallegri, Franco, Ottonello, Luciano, Liberale, Luca, Caserza, Lara, Salam, Kassem, Liberato, Nicola Lucio, Tognin, Tiziana, Bianchi, Giovanni Battista, Giaquinto, Sabrina, Purrello, Francesco, Di Pino, Antonino, Piro, Salvatore, Rozzini, Renzo, Falanga, Lina, Spazzini, Elena, Ferrandina, Camillo, Montrucchio, Giuseppe, Petitti, Paolo, Peasso, Paolo, Favale, Edoardo, Poletto, Cesare, Salmi, Raffaella, Gaudenzi, Piergiorgio, Violi, Francesco, Perri, Ludovica, Landolfi, Raffaele, Montalto, Massimo, Mirijello, Antonio, Guasti, Luigina, Castiglioni, Luana, Maresca, Andrea, Squizzato, Alessandro, Campiotti, Leonardo, Grossi, Alessandra, Bertolotti, Marco, Mussi, Chiara, Lancellotti, Giulia, Libbra, Maria Vittoria, Dondi, Giulia, Pellegrini, Elisa, Carulli, Lucia, Galassi, Matteo, Grassi, Yasmine, Perticone, Francesco, Perticone, Maria, Battaglia, Rosa, Filice, Marco, Maio, Raffaele, Stanghellini, Vincenzo, Ruggeri, Eugenio, del Vecchio, Sara, Salvi, Andrea, Leonardi, Roberto, Damiani, Giampaolo, Capeci, William, Gabrielli, Armando, Mattioli, Massimo, Martino, Giuseppe Pio, Biondi, Lorenzo, Pettinari, Pietro, Ghio, Riccardo, Dal Col, Anna, Minisola, Salvatore, Colangelo, Luciano, Cilli, Mirella, Labbadia, Giancarlo, Afeltra, Antonella, Marigliano, Benedetta, Pipita, Maria Elena, Castellino, Pietro, Zanoli, Luca, Pignataro, Samuele, Gennaro, Alfio, Blanco, Julien, Saracco, Valter, Fogliati, Marisa, Bussolino, Carlo, Mete, Francesca, Gino, Miriam, Cittadini, Antonio, Vigorito, Carlo, Arcopinto, Michele, Salzano, Andrea, Bobbio, Emanuele, Marra, Alberto Maria, Sirico, Domenico, Moreo, Guido, Gasparini, Francesca, Prolo, Silvia, Pina, Gloria, Ballestrero, Alberto, Ferrando, Fabio, Berra, Sergio, Dassi, Simonetta, Nava, Maria Cristina, Graziella, Bruno, Baldassarre, Stefano, Fragapani, Salvatore, Gruden, Gabriella, Galanti, Giorgio, Mascherini, Gabriele, Petri, Cristian, Stefani, Laura, Girino, Margherita, Piccinelli, Valeria, Nasso, Francesco, Gioffre, Vincenza, Pasquale, Maria, Scattolin, Giuseppe, Martinelli, Sergio, Turrin, Mauro, Sechi, Leonardo, Catena, Cristina, Colussi, Gianluca, Passariello, Nicola, Rinaldi, Luca, Berti, Franco, Famularo, Giuseppe, Tarsitani, Patrizia, Castello, Roberto, Pasino, Michela, Ceda, Gian Paolo, Maggio, Marcello Giuseppe, Morganti, Simonetta, Artoni, Andrea, Del Giacco, Stefano, Firinu, Davide, Losa, Francesca, Paoletti, Giovanni, Costanzo, Giulia, Montalto, Giuseppe, Licata, Anna, Malerba, Valentina, Montalto, Filippo Alessandro, Lasco, Antonino, Basile, Giorgio, Catalano, Antonino, Malatino, Lorenzo, Stancanelli, Benedetta, Terranova, Valentina, Di Marca, Salvatore, Di Quattro, Rosario, La Malfa, Lara, Caruso, Rossella, Mecocci, Patrizia, Ruggiero, Carmelinda, Boccardi, Virginia, Meschi, Tiziana, Lauretani, Fulvio, Ticinesi, Andrea, Nouvenne, Antonio, Minuz, Pietro, Fondrieschi, Luigi, Pirisi, Mario, Fra, Gian Paolo, Sola, Daniele, Porta, Massimo, Riva, Piero, Quadri, Roberto, Larovere, Erica, Novelli, Marco, Scanzi, Giorgio, Mengoli, Caterina, Provini, Stella, Ricevuti, Laura, Simeone, Emilio, Scurti, Rosa, Tolloso, Fabio, Tarquini, Roberto, Valoriani, Alice, Dolenti, Silvia, Vannini, Giulia, Tedeschi, Alberto, Trotta, Lucia, Volpi, Riccardo, Bocchi, Pietro, Vignali, Alessandro, Harari, Sergio, Lonati, Chiara, Cattaneo, Mara, Duque Nieves, Ramirez, Molinero Alberto, Muela, Requejo Pedro, Abad, Pelaez Vanessa, Lopez, Lara, Tamargo, Viros Xavier, Corbella, Francesc, Formiga, Manglano Jesus, Diez, Tello Esperanza, Bejarano, Behamonte Esther, Del Corral, Puras Maria, Sevil, Romero, Manuel, Llorente Blanca, Pinilla, Gonzalez-Cobos Cristina, Lopez, Victoria, Villalba Garcia M., Saez, Lopez, Bosco, Juan, Baena Susana, Sanz, Gallego Marta, Arroyo, Becerra Concepcion, Gonzalez, Moyano Antonio, Fernandez, Gomez Hernandez, Mercedes, Poyato Borrego, Manuel, Cuadros Raquel, Pacheco, Rojas Florencia, Perez, Olid Beatriz, Garcia, Garcia Sara, Carrascosa, Cervellera Alfonso, Gonzalez-Cruz, Martinez Marta, Peinado, Cantero Alberto, Ruiz, Arraigosa Antonio, Albarracin, Guerrero Montserrat, Godoy, Miguel Angel, Baron Ramos, Jose Manuel, Machin, Veleiro Ignacio, Novo, Suarez Lucia, Alvela, Alfonso, Lopez, Bran David, Rubal, Vazquez Iria, Iniguez, and Prego Monica, Rios

Subjects
Male, medicine.medical_specialty, Population, Socio-culturale, Renal function, Disease, 030204 cardiovascular system & hematology, Elderly in-patients, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Acute care, Epidemiology, eGFR, 80 and over, Internal Medicine, medicine, Humans, Renal Insufficiency, Hospital Mortality, 030212 general & internal medicine, Renal Insufficiency, Chronic, Chronic, education, Glomerular filtration rate estimation, Aged, Aged, 80 and over, Estimation, Creatinine, education.field_of_study, business.industry, Prognosis, Female, Italy, Glomerular Filtration Rate, Hospitalization, medicine.disease, Elderly in-patients, Glomerular filtration rate estimation, Prognosis, eGFR, chemistry, business, Kidney disease
Abstract

The estimated glomerular filtration rate (eGFR) is a predictor of important outcomes and its reduction has been associated with the risk of all-cause mortality in both general population and elderly patients. However while reduced renal function is common in older people, the best method for estimating GFR remains unclear, especially in an acute care setting. Most studies analyzing the accuracy of eGFR in the elderly were carried out in different heterogeneous settings. In this study, we compare the prognostic value of different formulas estimating GFR in predicting the risk of in-hospital morbidity and mortality within 3 months from discharge in elderly hospitalized patients. Data were extracted from “Registro Politerapia Societa Italiana di Medicina Interna (REPOSI)”. Patients with available creatinine values at hospital admission were selected and eGFR was calculated according to the different formulas: Cockcroft-Gault, Modification of Diet in Renal Disease equation, Chronic Kidney Disease Epidemiology Collaboration, Berlin Initiative Study and Full Age Spectrum. 4621 patients were included in the analysis. Among these, 4.2% and 14.2% died during hospitalization and within 3 months from discharge, respectively. eGFR > 60 ml/min/1.73 m2 at admission was associated with a very low risk of mortality during the hospital stay and within 90 days from discharge, while an eGFR

Published
2018

30. One Hour-Post-load Plasma Glucose ≥155 mg/dl in Healthy Glucose Normotolerant Subjects Is Associated With Subcortical Brain MRI Alterations and Impaired Cognition: A Pilot Study

Author

Perticone, Maria, primary, Di Lorenzo, Cherubino, additional, Arabia, Gennarina, additional, Arturi, Franco, additional, Caroleo, Benedetto, additional, Tassone, Bruno, additional, Pujia, Roberta, additional, Fiorentino, Teresa Vanessa, additional, Chiriaco, Carmelina, additional, Sesti, Giorgio, additional, Quattrone, Aldo, additional, and Perticone, Francesco, additional

Published
2021
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32. Prevalence of use and appropriateness of antidepressants prescription in acutely hospitalized elderly patients

Author

Mannucci, Pier Mannuccio, Nobili, Alessandro, Pietrangelo, Antonello, Perticone, Francesco, Licata, Giuseppe, Violi, Francesco, Corazza, Gino Roberto, Corrao, Salvatore, Marengoni, Alessandra, Salerno, Francesco, Cesari, Matteo, Tettamanti, Mauro, Pasina, Luca, Franchi, Carlotta, Cortesi, Laura, Miglio, Gabriella, Ardoino, Ilaria, Novella, Alessio, Prisco, Domenico, Silvestri, Elena, Emmi, Giacomo, Bettiol, Alessandra, Caterina, Cenci, Biolo, Gianni, Zanetti, Michela, Guadagni, Martina, Zaccari, Michele, Chiuch, Massimiliano, Vanoli, Massimo, Grignani, Giulia, Pulixi, Edoardo Alessandro, Bernardi, Mauro, Bassi, Silvia Li, Santi, Luca, Zaccherini, Giacomo, Lupattelli, Graziana, Mannarino, Elmo, Bianconi, Vanessa, Paciullo, Francesco, Alcidi, Riccardo, Nuti, Ranuccio, Valenti, Roberto, Ruvio, Martina, Cappelli, Silvia, Palazzuoli, Alberto, Girelli, Domenico, Busti, Fabiana, Marchi, Giacomo, Barbagallo, Mario, Dominguez, Ligia, Cocita, Floriana, Beneduce, Vincenza, Plances, Lidia, Natoli, Giuseppe, Mularo, Salvatore, Raspanti, Massimo, Cavallaro, Federica, Zoli, Marco, Lazzari, Ilaria, Brunori, Mattia, Fabbri, Elisa, Magalotti, Donatella, Arnò, Raffaella, Pasini, Franco Laghi, Capecchi, Pier Leopoldo, Palasciano, Giuseppe, Modeo, Maria Ester, Gennaro, Carla Di, Cappellini, Maria Domenica, Maira, Diletta, Di Stefano, Valeria, Fabio, Giovanna, Seghezzi, Sonia, Mancarella, Marta, De Amicis, Margherita Migone, De Luca, Giacomo, Scaramellini, Natalia, Rossi, Paolo Dionigi, Damanti, Sarah, Clerici, Marta, Conti, Federica, Bonini, Giulia, Ottolini, Barbara Brignolo, Di Sabatino, Antonio, Miceli, Emanuela, Lenti, Marco Vincenzo, Pisati, Martina, Dominioni, Costanza Caccia, Murialdo, Giovanni, Marra, Alessio, Cattaneo, Federico, Pontremoli, Roberto, Beccati, Valentina, Nobili, Giulia, Secchi, Maria Beatrice, Ghelfi, Davide, Anastasio, Luigi, Sofia, Lucia, Carbone, Maria, Cipollone, Francesco, Guagnano, Maria Teresa, Valeriani, Emanuele, Rossi, Ilaria, Mancuso, Gerardo, Calipari, Daniela, Bartone, Mosè, Delitala, Giuseppe, Berria, Maria, Pes, Chiara, Delitala, Alessandro, Muscaritoli, Maurizio, Molfino, Alessio, Petrillo, Enrico, Zuccalà, Giuseppe, D’Aurizio, Gabriella, Romanelli, Giuseppe, Zucchelli, Alberto, Manzoni, Francesca, Volpini, Andrea, Picardi, Antonio, Gentilucci, Umberto Vespasiani, Gallo, Paolo, Dell’Unto, Chiara, Annoni, Giorgio, Corsi, Maurizio, Bellelli, Giuseppe, Zazzetta, Sara, Mazzola, Paolo, Szabo, Hajnalka, Bonfanti, Alessandra, Arturi, Franco, Succurro, Elena, Rubino, Mariangela, Tassone, Bruno, Sesti, Giorgio, Interna, Medicina, Serra, Maria Grazia, Bleve, Maria Antonietta, Gasbarrone, Laura, Sajeva, Maria Rosaria, Brucato, Antonio, Ghidoni, Silvia, Fabris, Fabrizio, Bertozzi, Irene, Bogoni, Giulia, Rabuini, Maria Victoria, Cosi, Elisabetta, Scarinzi, Paolo, Amabile, Annalisa, Omenetto, Elisabetta, Prandini, Tancredi, Manfredini, Roberto, Fabbian, Fabio, Boari, Benedetta, Giorgi, Alfredo De, Tiseo, Ruana, De Giorgio, Roberto, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Borghi, Claudio, Strocchi, Enrico, Ianniello, Eugenia, Soldati, Mario, Sabbà, Carlo, Vella, Francesco Saverio, Suppressa, Patrizia, Schilardi, Andrea, Loparco, Francesca, De Vincenzo, Giovanni Michele, Comitangelo, Alessio, Amoruso, Emanuele, Fenoglio, Luigi, Falcetta, Andrea, Bracco, Christian, Fracanzani, Anna L., Fargion, Silvia, Tiraboschi, Silvia, Cespiati, Annalisa, Oberti, Giovanna, Sigon, Giordano, Peyvandi, Flora, Rossio, Raffaella, Ferrari, Barbara, Colombo, Giulia, Agosti, Pasquale, Monzani, Valter, Savojardo, Valeria, Folli, Christian, Ceriani, Giuliana, Pallini, Giada, Dallegri, Franco, Ottonello, Luciano, Liberale, Luca, Caserza, Lara, Salam, Kassem, Liberato, Nicola Lucio, Tognin, Tiziana, Bianchi, Giovanni Battista, Giaquinto, Sabrina, Purrello, Francesco, Di Pino, Antonino, Piro, Salvatore, Rozzini, Renzo, Falanga, Lina, Spazzini, Elena, Ferrandina, Camillo, Montrucchio, Giuseppe, Petitti, Paolo, Peasso, Paolo, Favale, Edoardo, Poletto, Cesare, Salmi, Raffaella, Gaudenzi, Piergiorgio, Perri, Ludovica, Landolfi, Raffaele, Montalto, Massimo, Mirijello, Antonio, Guasti, Luigina, Castiglioni, Luana, Maresca, Andrea, Squizzato, Alessandro, Campiotti, Leonardo, Grossi, Alessandra, Bertolotti, Marco, Mussi, Chiara, Lancellotti, Giulia, Libbra, Maria Vittoria, Dondi, Giulia, Pellegrini, Elisa, Carulli, Lucia, Galassi, Matteo, Grassi, Yasmine, Perticone, Maria, Battaglia, Rosa, FIlice, Marco, Maio, Raffaele, Stanghellini, Vincenzo, Ruggeri, Eugenio, del Vecchio, Sara, Salvi, Andrea, Leonardi, Roberto, Damiani, Giampaolo, Capeci, William, Gabrielli, Armando, Mattioli, Massimo, Martino, Giuseppe Pio, Biondi, Lorenzo, Pettinari, Pietro, Ghio, Riccardo, Col, Anna Dal, Minisola, Salvatore, Colangelo, Luciano, Cilli, Mirella, Labbadia, Giancarlo, Afeltra, Antonella, Marigliano, Benedetta, Pipita, Maria Elena, Castellino, Pietro, Zanoli, Luca, Pignataro, Samuele, Gennaro, Alfio, Blanco, Julien, Saracco, Valter, Fogliati, Marisa, Bussolino, Carlo, Mete, Francesca, Gino, Miriam, Cittadini, Antonio, Vigorito, Carlo, Arcopinto, Michele, Salzano, Andrea, Bobbio, Emanuele, Marra, Alberto Maria, Sirico, Domenico, Moreo, Guido, Gasparini, Francesca, Prolo, Silvia, Pina, Gloria, Ballestrero, Alberto, Ferrando, Fabio, Berra, Sergio, Dassi, Simonetta, Nava, Maria Cristina, Graziella, Bruno, Baldassarre, Stefano, Fragapani, Salvatore, Gruden, Gabriella, Galanti, Giorgio, Mascherini, Gabriele, Petri, Cristian, Stefani, Laura, Girino, Margherita, Piccinelli, Valeria, Nasso, Francesco, Gioffrè, Vincenza, Pasquale, Maria, Scattolin, Giuseppe, Martinelli, Sergio, Turrin, Mauro, Sechi, Leonardo, Catena, Cristina, Colussi, Gianluca, Passariello, Nicola, Rinaldi, Luca, Berti, Franco, Famularo, Giuseppe, Tarsitani, Patrizia, Castello, Roberto, Pasino, Michela, Ceda, Gian Paolo, Maggio, Marcello Giuseppe, Morganti, Simonetta, Artoni, Andrea, Del Giacco, Stefano, Firinu, Davide, Losa, Francesca, Paoletti, Giovanni, Costanzo, Giulia, Montalto, Giuseppe, Licata, Anna, Malerba, Valentina, Montalto, Filippo Alessandro, Lasco, Antonino, Basile, Giorgio, Catalano, Antonino, Malatino, Lorenzo, Stancanelli, Benedetta, Terranova, Valentina, Di Marca, Salvatore, Di Quattro, Rosario, La Malfa, Lara, Caruso, Rossella, Mecocci, Patrizia, Ruggiero, Carmelinda, Boccardi, Virginia, Meschi, Tiziana, Lauretani, Fulvio, Ticinesi, Andrea, Nouvenne, Antonio, Minuz, Pietro, Fondrieschi, Luigi, Pirisi, Mario, Fra, Gian Paolo, Sola, Daniele, Porta, Massimo, Riva, Piero, Quadri, Roberto, Larovere, Erica, Novelli, Marco, Scanzi, Giorgio, Mengoli, Caterina, Provini, Stella, Ricevuti, Laura, Simeone, Emilio, Scurti, Rosa, Tolloso, Fabio, Tarquini, Roberto, Valoriani, Alice, Dolenti, Silvia, Vannini, Giulia, Tedeschi, Alberto, Trotta, Lucia, Volpi, Riccardo, Bocchi, Pietro, Vignali, Alessandro, Harari, Sergio, Lonati, Chiara, Cattaneo, Mara, Napoli, Federico, Carlotta, Franchi, Raffaella, Rossio, Ilaria, Ardoino, Alessandro, Nobili, and Mannuccio, Mannucci Pier

Published
2019
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33. Characteristics, Management, and Outcomes of Elderly Patients With Diabetes in a COVID-19 Unit: Lessons Learned.

Author

Ricchio, Marco, primary, Tassone, Bruno, additional, Pelle, Maria Chiara, additional, Mazzitelli, Maria, additional, Serapide, Francesca, additional, Fusco, Paolo, additional, Lionello, Rosaria, additional, Cancelliere, Anna, additional, Procopio, Giada, additional, Lio, Elena, additional, Trecarichi, Enrico Maria, additional, Torti, Carlo, additional, and Irace, Concetta, additional

Published
2020
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34. Use of subcutaneous tocilizumab in patients with COVID‐19 pneumonia

Author

Mazzitelli, Maria, primary, Arrighi, Eugenio, additional, Serapide, Francesca, additional, Pelle, Maria Chiara, additional, Tassone, Bruno, additional, Lionello, Rosaria, additional, Marrazzo, Giuseppina, additional, Laganà, Domenico, additional, Costanzo, Francesco Saverio, additional, Matera, Giovanni, additional, Trecarichi, Enrico Maria, additional, and Torti, Carlo, additional

Published
2020
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35. Sex-Differences in the Pattern of Comorbidities, Functional Independence, and Mortality in Elderly Inpatients: Evidence from the RePoSI Register

Author

Corrao, Salvatore, Argano, Christiano, Natoli, Giuseppe, Nobili, Alessandro, Corazza, Gino Roberto, Mannucci, Pier Mannuccio, Perticone, Francesco, Prisco, Domenico, Silvestri, Elena, Emmi, Giacomo, Bettiol, Alessandra, Caterina, Cenci, Biolo, Gianni, Zanetti, Michela, Guadagni, Martina, Zaccari, Michele, Chiuch, Massimiliano, Vanoli, Massimo, Grignani, Giulia, Pulixi, Edoardo Alessandro, Bernardi, Mauro, Bassi, Silvia Li, Santi, Luca, Zaccherini, Giacomo, Lupattelli, Graziana, Mannarino, Elmo, Bianconi, Vanessa, Paciullo, Francesco, Alcidi, Riccardo, Nuti, Ranuccio, Valenti, Roberto, Ruvio, Martina, Cappelli, Silvia, Palazzuoli, Alberto, Girelli, Domenico, Busti, Fabiana, Marchi, Giacomo, Barbagallo, Mario, Dominguez, Ligia, Cocita, Floriana, Beneduce, Vincenza, Plances, Lidia, Mularo, Salvatore, Raspanti, Massimo, Cavallaro, Federica, Zoli, Marco, Lazzari, Ilaria, Brunori, Mattia, Fabbri, Elisa, Magalotti, Donatella, Arno, Raffaella, Pasini, Franco Laghi, Capecchi, Pier Leopoldo, Palasciano, Giuseppe, Modeo, Maria Ester, Di Gennaro, Carla, Cappellini, Maria Domenica, Maira, Diletta, Di Stefano, Valeria, Fabio, Giovanna, Seghezzi, Sonia, Mancarella, Marta, De Amicis, Margherita Migone, De Luca, Giacomo, Scaramellini, Natalia, Cesari, Matteo, Rossi, Paolo Dionigi, Damanti, Sarah, Clerici, Marta, Conti, Federica, Bonini, Giulia, Ottolini, Barbara Brignolo, Di Sabatino, Antonio, Miceli, Emanuela, Lenti, Marco Vincenzo, Pisati, Martina, Dominioni, Costanza Caccia, Murialdo, Giovanni, Marra, Alessio, Cattaneo, Federico, Pontremoli, Roberto, Beccati, Valentina, Nobili, Giulia, Secchi, Maria Beatrice, Ghelfi, Davide, Anastasio, Luigi, Sofia, Lucia, Carbone, Maria, Cipollone, Francesco, Guagnano, Maria Teresa, Valeriani, Emanuele, Rossi, Ilaria, Mancuso, Gerardo, Calipari, Daniela, Bartone, Mose, Delitala, Giuseppe, Berria, Maria, Pes, Chiara, Delitala, Alessandro, Muscaritoli, Maurizio, Molfino, Alessio, Petrillo, Enrico, Zuccala, Giuseppe, D'Aurizio, Gabriella, Romanelli, Giuseppe, Marengoni, Alessandra, Zucchelli, Alberto, Manzoni, Francesca, Volpini, Andrea, Picardi, Antonio, Gentilucci, Umberto Vespasiani, Gallo, Paolo, Dell'Unto, Chiara, Annoni, Giorgio, Corsi, Maurizio, Bellelli, Giuseppe, Zazzetta, Sara, Mazzola, Paolo, Szabo, Hajnalka, Bonfanti, Alessandra, Arturi, Franco, Succurro, Elena, Rubino, Mariangela, Tassone, Bruno, Sesti, Giorgio, Serra, Maria Grazia, Bleve, Maria Antonietta, Gasbarrone, Laura, Sajeva, Maria Rosaria, Brucato, Antonio, Ghidoni, Silvia, Fabris, Fabrizio, Bertozzi, Irene, Bogoni, Giulia, Rabuini, Maria Victoria, Cosi, Elisabetta, Scarinzi, Paolo, Amabile, Annalisa, Omenetto, Elisabetta, Prandini, Tancredi, Manfredini, Roberto, Fabbian, Fabio, Boari, Benedetta, De Giorgi, Alfredo, Tiseo, Ruana, De Giorgio, Roberto, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Borghi, Claudio, Strocchi, Enrico, Ianniello, Eugenia, Soldati, Mario, Sabba, Carlo, Vella, Francesco Saverio, Suppressa, Patrizia, Agosti, Pasquale, Schilardi, Andrea, Loparco, Francesca, De Vincenzo, Giovanni Michele, Comitangelo, Alessio, Amoruso, Emanuele, Fenoglio, Luigi, Falcetta, Andrea, Bracco, Christian, Fracanzani, Anna L., Fargion, Silvia, Tiraboschi, Silvia, Cespiati, Annalisa, Oberti, Giovanna, Sigon, Giordano, Peyvandi, Flora, Rossio, Raffaella, Ferrari, Barbara, Colombo, Giulia, Monzani, Valter, Savojardo, Valeria, Folli, Christian, Ceriani, Giuliana, Salerno, Francesco, Pallini, Giada, Dallegri, Franco, Ottonello, Luciano, Liberale, Luca, Caserza, Lara, Salam, Kassem, Liberato, Nicola Lucio, Tognin, Tiziana, Bianchi, Giovanni Battista, Giaquinto, Sabrina, Purrello, Francesco, Di Pino, Antonino, Piro, Salvatore, Rozzini, Renzo, Falanga, Lina, Spazzini, Elena, Ferrandina, Camillo, Montrucchio, Giuseppe, Petitti, Paolo, Peasso, Paolo, Favale, Edoardo, Poletto, Cesare, Salmi, Raffaella, Gaudenzi, Piergiorgio, Violi, Francesco, Perri, Ludovica, Landolfi, Raffaele, Montalto, Massimo, Mirijello, Antonio, Guasti, Luigina, Castiglioni, Luana, Maresca, Andrea, Squizzato, Alessandro, Campiotti, Leonardo, Grossi, Alessandra, Bertolotti, Marco, Mussi, Chiara, Lancellotti, Giulia, Libbra, Maria Vittoria, Dondi, Giulia, Pellegrini, Elisa, Carulli, Lucia, Galassi, Matteo, Grassi, Yasmine, Perticone, Maria, Battaglia, Rosa, Filice, Marco, Maio, Raffaele, Stanghellini, Vincenzo, Ruggeri, Eugenio, del Vecchio, Sara, Salvi, Andrea, Leonardi, Roberto, Damiani, Giampaolo, Capeci, William, Gabrielli, Armando, Mattioli, Massimo, Martino, Giuseppe Pio, Biondi, Lorenzo, Pettinari, Pietro, Ghio, Riccardo, Dal Col, Anna, Minisola, Salvatore, Colangelo, Luciano, Cilli, Mirella, Labbadia, Giancarlo, Afeltra, Antonella, Marigliano, Benedetta, Pipita, Maria Elena, Castellino, Pietro, Zanoli, Luca, Pignataro, Samuele, Gennaro, Alfio, Blanco, Julien, Saracco, Valter, Fogliati, Marisa, Bussolino, Carlo, Mete, Francesca, Gino, Miriam, Cittadini, Antonio, Vigorito, Carlo, Arcopinto, Michele, Salzano, Andrea, Bobbio, Emanuele, Marra, Alberto Maria, Sirico, Domenico, Moreo, Guido, Gasparini, Francesca, Prolo, Silvia, Pina, Gloria, Ballestrero, Alberto, Ferrando, Fabio, Berra, Sergio, Dassi, Simonetta, Nava, Maria Cristina, Graziella, Bruno, Baldassarre, Stefano, Fragapani, Salvatore, Gruden, Gabriella, Galanti, Giorgio, Mascherini, Gabriele, Petri, Cristian, Stefani, Laura, Girino, Margherita, Piccinelli, Valeria, Nasso, Francesco, Gioffre, Vincenza, Pasquale, Maria, Scattolin, Giuseppe, Martinelli, Sergio, Turrin, Mauro, Sechi, Leonardo, Catena, Cristina, Colussi, Gianluca, Passariello, Nicola, Rinaldi, Luca, Berti, Franco, Famularo, Giuseppe, Tarsitani, Patrizia, Castello, Roberto, Pasino, Michela, Ceda, Gian Paolo, Maggio, Marcello Giuseppe, Morganti, Simonetta, Artoni, Andrea, Del Giacco, Stefano, Firinu, Davide, Losa, Francesca, Paoletti, Giovanni, Costanzo, Giulia, Montalto, Giuseppe, Licata, Anna, Malerba, Valentina, Montalto, Filippo Alessandro, Lasco, Antonino, Basile, Giorgio, Catalano, Antonino, Malatino, Lorenzo, Stancanelli, Benedetta, Terranova, Valentina, Di Marca, Salvatore, Di Quattro, Rosario, La Malfa, Lara, Caruso, Rossella, Mecocci, Patrizia, Ruggiero, Carmelinda, Boccardi, Virginia, Meschi, Tiziana, Lauretani, Fulvio, Ticinesi, Andrea, Nouvenne, Antonio, Minuz, Pietro, Fondrieschi, Luigi, Pirisi, Mario, Fra, Gian Paolo, Sola, Daniele, Porta, Massimo, Riva, Piero, Quadri, Roberto, Larovere, Erica, Novelli, Marco, Scanzi, Giorgio, Mengoli, Caterina, Provini, Stella, Ricevuti, Laura, Simeone, Emilio, Scurti, Rosa, Tolloso, Fabio, Tarquini, Roberto, Valoriani, Alice, Dolenti, Silvia, Vannini, Giulia, Tedeschi, Alberto, Trotta, Lucia, Volpi, Riccardo, Bocchi, Pietro, Vignali, Alessandro, Harari, Sergio, Lonati, Chiara, Cattaneo, Mara, Napoli, Federico, Corrao, Salvatore, Argano, Christiano, Natoli, Giuseppe, Nobili, Alessandro, Corazza, Gino Roberto, Mannucci, Pier Mannuccio, Perticone, Francesco, and Rinaldi, Luca

Subjects
medicine.medical_specialty, Multivariate analysis, lcsh:Medicine, Socio-culturale, Disease, 030204 cardiovascular system & hematology, elderly, Article, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Medicine, 030212 general & internal medicine, Depression (differential diagnoses), Polypharmacy, business.industry, lcsh:R, General Medicine, medicine.disease, Comorbidity, elderly, sex profiles, disease distribution, in-hospital mortality, 3-month mortality, 1-year mortality, Mood disorders, disease distribution, 1-year mortality, 3-month mortality, sex profiles, business, in-hospital mortality, Kidney disease
Abstract

Background: The RePoSi study has provided data on comorbidities, polypharmacy, and sex dimorphism in hospitalised elderly patients. Methods: We retrospectively analysed data collected from the 2010, 2012, 2014, and 2016 data sets of the RePoSi register. The aim of this study was to explore the sex-differences and to validate the multivariate model in the entire dataset with an expanded follow-up at 1 year. Results: Among 4714 patients, 51% were women and 49% were men. The disease distribution showed that diabetes, coronary artery disease, chronic obstructive pulmonary disease, chronic kidney disease, and malignancy were more frequent in men but that hypertension, anaemia, osteoarthritis, depression, and diverticulitis disease were more common in women. Severity and comorbidity indexes according to the Cumulative Illness Rating Scale (CIRS-s and CIRS-c) were higher in men, while cognitive impairment, mood disorders, and disability in daily life measured by the Barthel Index (BI) were worse in women. In the multivariate analysis, BI, CIRS, and malignancy significantly increased the risk of death in men at the 1-year follow-up, while age was independently associated with mortality in women. Conclusions: Our study highlighted the relevance and the validity of our previous predictive model in the identification of sex dimorphism in hospitalised elderly patients underscoring the need of sex-personalised health-care.

Published
2019

36. Prevalence, characteristics and treatment of chronic pain in elderly patients hospitalized in internal medicine wards

Author

Corsi, Nicole, Roberto, Anna, Cortesi, Laura, Nobili, Alessandro, Mannucci, Pier Mannuccio, Corli, Oscar, Prisco, Domenico, Silvestri, Elena, Emmi, Giacomo, Bettiol, Alessandra, Caterina, Cenci, Biolo, Gianni, Zanetti, Michela, Guadagni, Martina, Zaccari, Michele, Chiuch, Massimiliano, Vanoli, Massimo, Grignani, Giulia, Pulixi, Edoardo Alessandro, Bernardi, Mauro, Bassi, Silvia Li, Santi, Luca, Zaccherini, Giacomo, Lupattelli, Graziana, Mannarino, Elmo, Bianconi, Vanessa, Paciullo, Francesco, Alcidi, Riccardo, Nuti, Ranuccio, Valenti, Roberto, Ruvio, Martina, Cappelli, Silvia, Palazzuoli, Alberto, Girelli, Domenico, Busti, Fabiana, Marchi, Giacomo, Barbagallo, Mario, Dominguez, Ligia, Cocita, Floriana, Beneduce, Vincenza, Plances, Lidia, Corrao, Salvatore, Natoli, Giuseppe, Mularo, Salvatore, Raspanti, Massimo, Cavallaro, Federica, Zoli, Marco, Lazzari, Ilaria, Brunori, Mattia, Fabbri, Elisa, Magalotti, Donatella, Arno, Raffaella, Pasini, Franco Laghi, Capecchi, Pier Leopoldo, Palasciano, Giuseppe, Modeo, Maria Ester, Di Gennaro, Carla, Cappellini, Maria Domenica, Maira, Diletta, Di Stefano, Valeria, Fabio, Giovanna, Seghezzi, Sonia, Mancarella, Marta, De Amicis, Margherita Migone, De Luca, Giacomo, Scaramellini, Natalia, Cesari, Matteo, Rossi, Paolo Dionigi, Damanti, Sarah, Clerici, Marta, Conti, Federica, Bonini, Giulia, Ottolini, Barbara Brignolo, Di Sabatino, Antonio, Miceli, Emanuela, Lenti, Marco Vincenzo, Pisati, Martina, Dominioni, Costanza Caccia, Murialdo, Giovanni, Marra, Alessio, Cattaneo, Federico, Pontremoli, Roberto, Beccati, Valentina, Nobili, Giulia, Secchi, Maria Beatrice, Ghelfi, Davide, Anastasio, Luigi, Sofia, Lucia, Carbone, Maria, Cipollone, Francesco, Guagnano, Maria Teresa, Valeriani, Emanuele, Rossi, Ilaria, Mancuso, Gerardo, Calipari, Daniela, Bartone, Mose, Delitala, Giuseppe, Berria, Maria, Pes, Chiara, Delitala, Alessandro, Muscaritoli, Maurizio, Molfino, Alessio, Petrillo, Enrico, Zuccala, Giuseppe, D'Aurizio, Gabriella, Romanelli, Giuseppe, Marengoni, Alessandra, Zucchelli, Alberto, Manzoni, Francesca, Volpini, Andrea, Picardi, Antonio, Gentilucci, Umberto Vespasiani, Gallo, Paolo, Dell'Unto, Chiara, Annoni, Giorgio, Corsi, Maurizio, Bellelli, Giuseppe, Zazzetta, Sara, Mazzola, Paolo, Szabo, Hajnalka, Bonfanti, Alessandra, Arturi, Franco, Succurro, Elena, Rubino, Mariangela, Tassone, Bruno, Sesti, Giorgio, Serra, Maria Grazia, Bleve, Maria Antonietta, Gasbarrone, Laura, Sajeva, Maria Rosaria, Brucato, Antonio, Ghidoni, Silvia, Fabris, Fabrizio, Bertozzi, Irene, Bogoni, Giulia, Rabuini, Maria Victoria, Cosi, Elisabetta, Scarinzi, Paolo, Amabile, Annalisa, Omenetto, Elisabetta, Prandini, Tancredi, Manfredini, Roberto, Fabbian, Fabio, Boari, Benedetta, De Giorgi, Alfredo, Tiseo, Ruana, De Giorgio, Roberto, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Borghi, Claudio, Strocchi, Enrico, Ianniello, Eugenia, Soldati, Mario, Sabba, Carlo, Vella, Francesco Saverio, Suppressa, Patrizia, Agosti, Pasquale, Schilardi, Andrea, Loparco, Francesca, De Vincenzo, Giovanni Michele, Comitangelo, Alessio, Amoruso, Emanuele, Fenoglio, Luigi, Falcetta, Andrea, Bracco, Christian, Fracanzani, Anna L., Fargion, Silvia, Tiraboschi, Silvia, Cespiati, Annalisa, Oberti, Giovanna, Sigon, Giordano, Peyvandi, Flora, Rossio, Raffaella, Ferrari, Barbara, Colombo, Giulia, Monzani, Valter, Savojardo, Valeria, Folli, Christian, Ceriani, Giuliana, Salerno, Francesco, Pallini, Giada, Dallegri, Franco, Ottonello, Luciano, Liberale, Luca, Caserza, Lara, Salam, Kassem, Liberato, Nicola Lucio, Tognin, Tiziana, Bianchi, Giovanni Battista, Giaquinto, Sabrina, Purrello, Francesco, Di Pino, Antonino, Piro, Salvatore, Rozzini, Renzo, Falanga, Lina, Spazzini, Elena, Ferrandina, Camillo, Montrucchio, Giuseppe, Petitti, Paolo, Peasso, Paolo, Favale, Edoardo, Poletto, Cesare, Salmi, Raffaella, Gaudenzi, Piergiorgio, Violi, Francesco, Perri, Ludovica, Landolfi, Raffaele, Montalto, Massimo, Mirijello, Antonio, Guasti, Luigina, Castiglioni, Luana, Maresca, Andrea, Squizzato, Alessandro, Campiotti, Leonardo, Grossi, Alessandra, Bertolotti, Marco, Mussi, Chiara, Lancellotti, Giulia, Libbra, Maria Vittoria, Dondi, Giulia, Pellegrini, Elisa, Carulli, Lucia, Galassi, Matteo, Grassi, Yasmine, Perticone, Francesco, Perticone, Maria, Battaglia, Rosa, Filice, Marco, Maio, Raffaele, Stanghellini, Vincenzo, Ruggeri, Eugenio, del Vecchio, Sara, Salvi, Andrea, Leonardi, Roberto, Damiani, Giampaolo, Capeci, William, Gabrielli, Armando, Mattioli, Massimo, Martino, Giuseppe Pio, Biondi, Lorenzo, Pettinari, Pietro, Ghio, Riccardo, Dal Col, Anna, Minisola, Salvatore, Colangelo, Luciano, Cilli, Mirella, Labbadia, Giancarlo, Afeltra, Antonella, Marigliano, Benedetta, Pipita, Maria Elena, Castellino, Pietro, Zanoli, Luca, Pignataro, Samuele, Gennaro, Alfio, Blanco, Julien, Saracco, Valter, Fogliati, Marisa, Bussolino, Carlo, Mete, Francesca, Gino, Miriam, Cittadini, Antonio, Vigorito, Carlo, Arcopinto, Michele, Salzano, Andrea, Bobbio, Emanuele, Marra, Alberto Maria, Sirico, Domenico, Moreo, Guido, Gasparini, Francesca, Prolo, Silvia, Pina, Gloria, Ballestrero, Alberto, Ferrando, Fabio, Berra, Sergio, Dassi, Simonetta, Nava, Maria Cristina, Graziella, Bruno, Baldassarre, Stefano, Fragapani, Salvatore, Gruden, Gabriella, Galanti, Giorgio, Mascherini, Gabriele, Petri, Cristian, Stefani, Laura, Girino, Margherita, Piccinelli, Valeria, Nasso, Francesco, Gioffre, Vincenza, Pasquale, Maria, Scattolin, Giuseppe, Martinelli, Sergio, Turrin, Mauro, Sechi, Leonardo, Catena, Cristina, Colussi, Gianluca, Passariello, Nicola, Rinaldi, Luca, Berti, Franco, Famularo, Giuseppe, Tarsitani, Patrizia, Castello, Roberto, Pasino, Michela, Ceda, Gian Paolo, Maggio, Marcello Giuseppe, Morganti, Simonetta, Artoni, Andrea, Del Giacco, Stefano, Firinu, Davide, Losa, Francesca, Paoletti, Giovanni, Costanzo, Giulia, Montalto, Giuseppe, Licata, Anna, Malerba, Valentina, Montalto, Filippo Alessandro, Lasco, Antonino, Basile, Giorgio, Catalano, Antonino, Malatino, Lorenzo, Stancanelli, Benedetta, Terranova, Valentina, Di Marca, Salvatore, Di Quattro, Rosario, La Malfa, Lara, Caruso, Rossella, Mecocci, Patrizia, Ruggiero, Carmelinda, Boccardi, Virginia, Meschi, Tiziana, Lauretani, Fulvio, Ticinesi, Andrea, Nouvenne, Antonio, Minuz, Pietro, Fondrieschi, Luigi, Pirisi, Mario, Fra, Gian Paolo, Sola, Daniele, Porta, Massimo, Riva, Piero, Quadri, Roberto, Larovere, Erica, Novelli, Marco, Scanzi, Giorgio, Mengoli, Caterina, Provini, Stella, Ricevuti, Laura, Simeone, Emilio, Scurti, Rosa, Tolloso, Fabio, Tarquini, Roberto, Valoriani, Alice, Dolenti, Silvia, Vannini, Giulia, Tedeschi, Alberto, Trotta, Lucia, Volpi, Riccardo, Bocchi, Pietro, Vignali, Alessandro, Harari, Sergio, Lonati, Chiara, Cattaneo, Mara, Duque Nieves, Ramirez, Molinero Alberto, Muela, Requejo Pedro, Abad, Pelaez Vanessa, Lopez, Lara, Tamargo, Viros Xavier, Corbella, Francesc, Formiga, Manglano Jesus, Diez, Tello Esperanza, Bejarano, Behamonte Esther, Del Corral, Puras Maria, Sevil, Romero, Manuel, Llorente Blanca, Pinilla, Gonzalez-Cobos Cristina, Lopez, Victoria, Villalba Garcia M., Saez, Lopez, Bosco, Juan, Baena Susana, Sanz, Gallego Marta, Arroyo, Becerra Concepcion, Gonzalez, Moyano Antonio, Fernandez, Gomez Hernandez, Mercedes, Poyato Borrego, Manuel, Cuadros Raquel, Pacheco, Rojas Florencia, Perez, Olid Beatriz, Garcia, Garcia Sara, Carrascosa, Cervellera Alfonso, Gonzalez-Cruz, Martinez Marta, Peinado, Cantero Alberto, Ruiz, Arraigosa Antonio, Albarracin, Guerrero Montserrat, Godoy, Miguel Angel, Baron Ramos, Jose Manuel, Machin, Veleiro Ignacio, Novo, Suarez Lucia, Alvela, Alfonso, Lopez, Bran David, Rubal, Vazquez Iria, Iniguez, and Prego Monica, Rios

Subjects
Male, medicine.medical_specialty, Aging, Pharmacological therapy, Undertreatment, Socio-culturale, Chronic pain, Comorbidity, Pharmacological treatment, 03 medical and health sciences, 0302 clinical medicine, Cognition, Aging, Analgesic treatment, Chronic pain, Pain management, Undertreatment, Internal medicine, medicine, Hospital discharge, 80 and over, Internal Medicine, Elderly people, Cognitive status, Humans, 030212 general & internal medicine, Registries, Depression (differential diagnoses), Aged, Aged, 80 and over, Analgesics, business.industry, Depression, Settore MED/09 - MEDICINA INTERNA, medicine.disease, Pain management, Logistic Models, Italy, Analgesic treatment, Spain, Chronic Pain, Female, Hospital Units, Multivariate Analysis, Pain Management, business, Hospital stay, 030217 neurology & neurosurgery
Abstract

Chronic pain is a frequent characteristic of elderly people and represents an actual and still poorly debated topic.We investigated pain prevalence and intensity, and its pharmacological therapy in elderly patients hospitalized in 101 internal medicine wards.Taking advantage of the "REgistro POliterapie Società Italiana Medicina Interna" (REPOSI), we collected 2535 patients of whom almost a quarter was older than 85 years old. Among them, 582 patients were affected by pain (either chronic or acute) and 296 were diagnosed with chronic pain.Patients with pain showed worse cognitive status, higher depression and comorbidities, and a longer duration of hospital stay compared to those without pain (all p .0366). Patients with chronic pain revealed lower level of independency in their daily life, worse cognitive status and higher level of depression compared to acute pain patients (all p .0156). Moreover, most of them were not treated for pain at admission (73.4%) and half of them was not treated with any analgesic drug at discharge (50.5%). This difference affected also the reported levels of pain intensity. Patients who received analgesics at both admission and discharge remained stable (p = .172). Conversely, those not treated at admission who received an analgesic treatment during the hospital stay decreased their perceived pain (p .0001).Our results show the need to focus more attention on the pharmacological treatment of chronic pain, especially in hospitalized elderly patients, in order to support them and facilitate their daily life after hospital discharge.

Published
2018

38. Prevalence of use and appropriateness of antidepressants prescription in acutely hospitalized elderly patients

Author

Carlotta, Franchi, primary, Raffaella, Rossio, additional, Ilaria, Ardoino, additional, Alessandro, Nobili, additional, Mannuccio, Mannucci Pier, additional, Mannucci, Pier Mannuccio, additional, Nobili, Alessandro, additional, Pietrangelo, Antonello, additional, Perticone, Francesco, additional, Licata, Giuseppe, additional, Violi, Francesco, additional, Corazza, Gino Roberto, additional, Corrao, Salvatore, additional, Marengoni, Alessandra, additional, Salerno, Francesco, additional, Cesari, Matteo, additional, Tettamanti, Mauro, additional, Pasina, Luca, additional, Franchi, Carlotta, additional, Cortesi, Laura, additional, Miglio, Gabriella, additional, Ardoino, Ilaria, additional, Novella, Alessio, additional, Prisco, Domenico, additional, Silvestri, Elena, additional, Emmi, Giacomo, additional, Bettiol, Alessandra, additional, Caterina, Cenci, additional, Biolo, Gianni, additional, Zanetti, Michela, additional, Guadagni, Martina, additional, Zaccari, Michele, additional, Chiuch, Massimiliano, additional, Vanoli, Massimo, additional, Grignani, Giulia, additional, Pulixi, Edoardo Alessandro, additional, Bernardi, Mauro, additional, Bassi, Silvia Li, additional, Santi, Luca, additional, Zaccherini, Giacomo, additional, Lupattelli, Graziana, additional, Mannarino, Elmo, additional, Bianconi, Vanessa, additional, Paciullo, Francesco, additional, Alcidi, Riccardo, additional, Nuti, Ranuccio, additional, Valenti, Roberto, additional, Ruvio, Martina, additional, Cappelli, Silvia, additional, Palazzuoli, Alberto, additional, Girelli, Domenico, additional, Busti, Fabiana, additional, Marchi, Giacomo, additional, Barbagallo, Mario, additional, Dominguez, Ligia, additional, Cocita, Floriana, additional, Beneduce, Vincenza, additional, Plances, Lidia, additional, Natoli, Giuseppe, additional, Mularo, Salvatore, additional, Raspanti, Massimo, additional, Cavallaro, Federica, additional, Zoli, Marco, additional, Lazzari, Ilaria, additional, Brunori, Mattia, additional, Fabbri, Elisa, additional, Magalotti, Donatella, additional, Arnò, Raffaella, additional, Pasini, Franco Laghi, additional, Capecchi, Pier Leopoldo, additional, Palasciano, Giuseppe, additional, Modeo, Maria Ester, additional, Gennaro, Carla Di, additional, Cappellini, Maria Domenica, additional, Maira, Diletta, additional, Di Stefano, Valeria, additional, Fabio, Giovanna, additional, Seghezzi, Sonia, additional, Mancarella, Marta, additional, De Amicis, Margherita Migone, additional, De Luca, Giacomo, additional, Scaramellini, Natalia, additional, Rossi, Paolo Dionigi, additional, Damanti, Sarah, additional, Clerici, Marta, additional, Conti, Federica, additional, Bonini, Giulia, additional, Ottolini, Barbara Brignolo, additional, Di Sabatino, Antonio, additional, Miceli, Emanuela, additional, Lenti, Marco Vincenzo, additional, Pisati, Martina, additional, Dominioni, Costanza Caccia, additional, Murialdo, Giovanni, additional, Marra, Alessio, additional, Cattaneo, Federico, additional, Pontremoli, Roberto, additional, Beccati, Valentina, additional, Nobili, Giulia, additional, Secchi, Maria Beatrice, additional, Ghelfi, Davide, additional, Anastasio, Luigi, additional, Sofia, Lucia, additional, Carbone, Maria, additional, Cipollone, Francesco, additional, Guagnano, Maria Teresa, additional, Valeriani, Emanuele, additional, Rossi, Ilaria, additional, Mancuso, Gerardo, additional, Calipari, Daniela, additional, Bartone, Mosè, additional, Delitala, Giuseppe, additional, Berria, Maria, additional, Pes, Chiara, additional, Delitala, Alessandro, additional, Muscaritoli, Maurizio, additional, Molfino, Alessio, additional, Petrillo, Enrico, additional, Zuccalà, Giuseppe, additional, D’Aurizio, Gabriella, additional, Romanelli, Giuseppe, additional, Zucchelli, Alberto, additional, Manzoni, Francesca, additional, Volpini, Andrea, additional, Picardi, Antonio, additional, Gentilucci, Umberto Vespasiani, additional, Gallo, Paolo, additional, Dell’Unto, Chiara, additional, Annoni, Giorgio, additional, Corsi, Maurizio, additional, Bellelli, Giuseppe, additional, Zazzetta, Sara, additional, Mazzola, Paolo, additional, Szabo, Hajnalka, additional, Bonfanti, Alessandra, additional, Arturi, Franco, additional, Succurro, Elena, additional, Rubino, Mariangela, additional, Tassone, Bruno, additional, Sesti, Giorgio, additional, Interna, Medicina, additional, Serra, Maria Grazia, additional, Bleve, Maria Antonietta, additional, Gasbarrone, Laura, additional, Sajeva, Maria Rosaria, additional, Brucato, Antonio, additional, Ghidoni, Silvia, additional, Fabris, Fabrizio, additional, Bertozzi, Irene, additional, Bogoni, Giulia, additional, Rabuini, Maria Victoria, additional, Cosi, Elisabetta, additional, Scarinzi, Paolo, additional, Amabile, Annalisa, additional, Omenetto, Elisabetta, additional, Prandini, Tancredi, additional, Manfredini, Roberto, additional, Fabbian, Fabio, additional, Boari, Benedetta, additional, Giorgi, Alfredo De, additional, Tiseo, Ruana, additional, De Giorgio, Roberto, additional, Paolisso, Giuseppe, additional, Rizzo, Maria Rosaria, additional, Borghi, Claudio, additional, Strocchi, Enrico, additional, Ianniello, Eugenia, additional, Soldati, Mario, additional, Sabbà, Carlo, additional, Vella, Francesco Saverio, additional, Suppressa, Patrizia, additional, Schilardi, Andrea, additional, Loparco, Francesca, additional, De Vincenzo, Giovanni Michele, additional, Comitangelo, Alessio, additional, Amoruso, Emanuele, additional, Fenoglio, Luigi, additional, Falcetta, Andrea, additional, Bracco, Christian, additional, Fracanzani, Anna L., additional, Fargion, Silvia, additional, Tiraboschi, Silvia, additional, Cespiati, Annalisa, additional, Oberti, Giovanna, additional, Sigon, Giordano, additional, Peyvandi, Flora, additional, Rossio, Raffaella, additional, Ferrari, Barbara, additional, Colombo, Giulia, additional, Agosti, Pasquale, additional, Monzani, Valter, additional, Savojardo, Valeria, additional, Folli, Christian, additional, Ceriani, Giuliana, additional, Pallini, Giada, additional, Dallegri, Franco, additional, Ottonello, Luciano, additional, Liberale, Luca, additional, Caserza, Lara, additional, Salam, Kassem, additional, Liberato, Nicola Lucio, additional, Tognin, Tiziana, additional, Bianchi, Giovanni Battista, additional, Giaquinto, Sabrina, additional, Purrello, Francesco, additional, Di Pino, Antonino, additional, Piro, Salvatore, additional, Rozzini, Renzo, additional, Falanga, Lina, additional, Spazzini, Elena, additional, Ferrandina, Camillo, additional, Montrucchio, Giuseppe, additional, Petitti, Paolo, additional, Peasso, Paolo, additional, Favale, Edoardo, additional, Poletto, Cesare, additional, Salmi, Raffaella, additional, Gaudenzi, Piergiorgio, additional, Perri, Ludovica, additional, Landolfi, Raffaele, additional, Montalto, Massimo, additional, Mirijello, Antonio, additional, Guasti, Luigina, additional, Castiglioni, Luana, additional, Maresca, Andrea, additional, Squizzato, Alessandro, additional, Campiotti, Leonardo, additional, Grossi, Alessandra, additional, Bertolotti, Marco, additional, Mussi, Chiara, additional, Lancellotti, Giulia, additional, Libbra, Maria Vittoria, additional, Dondi, Giulia, additional, Pellegrini, Elisa, additional, Carulli, Lucia, additional, Galassi, Matteo, additional, Grassi, Yasmine, additional, Perticone, Maria, additional, Battaglia, Rosa, additional, FIlice, Marco, additional, Maio, Raffaele, additional, Stanghellini, Vincenzo, additional, Ruggeri, Eugenio, additional, del Vecchio, Sara, additional, Salvi, Andrea, additional, Leonardi, Roberto, additional, Damiani, Giampaolo, additional, Capeci, William, additional, Gabrielli, Armando, additional, Mattioli, Massimo, additional, Martino, Giuseppe Pio, additional, Biondi, Lorenzo, additional, Pettinari, Pietro, additional, Ghio, Riccardo, additional, Col, Anna Dal, additional, Minisola, Salvatore, additional, Colangelo, Luciano, additional, Cilli, Mirella, additional, Labbadia, Giancarlo, additional, Afeltra, Antonella, additional, Marigliano, Benedetta, additional, Pipita, Maria Elena, additional, Castellino, Pietro, additional, Zanoli, Luca, additional, Pignataro, Samuele, additional, Gennaro, Alfio, additional, Blanco, Julien, additional, Saracco, Valter, additional, Fogliati, Marisa, additional, Bussolino, Carlo, additional, Mete, Francesca, additional, Gino, Miriam, additional, Cittadini, Antonio, additional, Vigorito, Carlo, additional, Arcopinto, Michele, additional, Salzano, Andrea, additional, Bobbio, Emanuele, additional, Marra, Alberto Maria, additional, Sirico, Domenico, additional, Moreo, Guido, additional, Gasparini, Francesca, additional, Prolo, Silvia, additional, Pina, Gloria, additional, Ballestrero, Alberto, additional, Ferrando, Fabio, additional, Berra, Sergio, additional, Dassi, Simonetta, additional, Nava, Maria Cristina, additional, Graziella, Bruno, additional, Baldassarre, Stefano, additional, Fragapani, Salvatore, additional, Gruden, Gabriella, additional, Galanti, Giorgio, additional, Mascherini, Gabriele, additional, Petri, Cristian, additional, Stefani, Laura, additional, Girino, Margherita, additional, Piccinelli, Valeria, additional, Nasso, Francesco, additional, Gioffrè, Vincenza, additional, Pasquale, Maria, additional, Scattolin, Giuseppe, additional, Martinelli, Sergio, additional, Turrin, Mauro, additional, Sechi, Leonardo, additional, Catena, Cristina, additional, Colussi, Gianluca, additional, Passariello, Nicola, additional, Rinaldi, Luca, additional, Berti, Franco, additional, Famularo, Giuseppe, additional, Tarsitani, Patrizia, additional, Castello, Roberto, additional, Pasino, Michela, additional, Ceda, Gian Paolo, additional, Maggio, Marcello Giuseppe, additional, Morganti, Simonetta, additional, Artoni, Andrea, additional, Del Giacco, Stefano, additional, Firinu, Davide, additional, Losa, Francesca, additional, Paoletti, Giovanni, additional, Costanzo, Giulia, additional, Montalto, Giuseppe, additional, Licata, Anna, additional, Malerba, Valentina, additional, Montalto, Filippo Alessandro, additional, Lasco, Antonino, additional, Basile, Giorgio, additional, Catalano, Antonino, additional, Malatino, Lorenzo, additional, Stancanelli, Benedetta, additional, Terranova, Valentina, additional, Di Marca, Salvatore, additional, Di Quattro, Rosario, additional, La Malfa, Lara, additional, Caruso, Rossella, additional, Mecocci, Patrizia, additional, Ruggiero, Carmelinda, additional, Boccardi, Virginia, additional, Meschi, Tiziana, additional, Lauretani, Fulvio, additional, Ticinesi, Andrea, additional, Nouvenne, Antonio, additional, Minuz, Pietro, additional, Fondrieschi, Luigi, additional, Pirisi, Mario, additional, Fra, Gian Paolo, additional, Sola, Daniele, additional, Porta, Massimo, additional, Riva, Piero, additional, Quadri, Roberto, additional, Larovere, Erica, additional, Novelli, Marco, additional, Scanzi, Giorgio, additional, Mengoli, Caterina, additional, Provini, Stella, additional, Ricevuti, Laura, additional, Simeone, Emilio, additional, Scurti, Rosa, additional, Tolloso, Fabio, additional, Tarquini, Roberto, additional, Valoriani, Alice, additional, Dolenti, Silvia, additional, Vannini, Giulia, additional, Tedeschi, Alberto, additional, Trotta, Lucia, additional, Volpi, Riccardo, additional, Bocchi, Pietro, additional, Vignali, Alessandro, additional, Harari, Sergio, additional, Lonati, Chiara, additional, Cattaneo, Mara, additional, and Napoli, Federico, additional

Published
2019
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39. Late-onset myocardial infarction and autoimmune haemolytic anaemia in a COVID-19 patient without respiratory symptoms, concomitant with a paradoxical increase in inflammatory markers: a case report.

Author

Pelle, Maria Chiara, Tassone, Bruno, Ricchio, Marco, Mazzitelli, Maria, Davoli, Chiara, Procopio, Giada, Cancelliere, Anna, La Gamba, Valentina, Lio, Elena, Matera, Giovanni, Quirino, Angela, Barreca, Giorgio Settimo, Trecarichi, Enrico Maria, Torti, Carlo, IDTM UMG COVID-19 Group, Arrighi, Eugenio, Bertucci, Bernardo, Busceti, Maria Teresa, Carallo, Claudio, and Costanzo, Francesco Saverio

Subjects
*AUTOIMMUNE hemolytic anemia, *MYOCARDIAL infarction, *COVID-19, *SYMPTOMS, *SARS-CoV-2, *ACUTE coronary syndrome
Abstract

Background: In December 2019, a new coronavirus (named severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) spread from China, causing a pandemic in a very short time. The main clinical presentation of SARS-CoV-2 infection (COVID-19, coronavirus disease-2019) is pneumonia, but several cardiovascular complications may also occur (e.g., acute coronary syndromes, pulmonary embolism, stroke, arrhythmias, heart failure and cardiogenic shock). Direct or indirect mechanisms induced by SARS-CoV-2 could be implicated in the pathogenesis of these events.Case Presentation: We report herein the third case of COVID-19 autoimmune haemolytic anaemia (AIHA) reported so far, which occurredwithout any other possible explanations in a Caucasian patient. The patient also suffered from ST-elevation myocardial injury.Conclusions: Both complications occurred quite late after COVID-19 diagnosis and were probably precipitated by systemic inflammation, as indicated by a significant delayed increase in inflammatory markers, including interleukin-6 (IL-6). [ABSTRACT FROM AUTHOR]

Published
2020
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42. I giudici e l'analisi economica del diritto due anni dopo

Author

Pardolesi Roberto and Tassone Bruno

Abstract

Two years after the publication of the book aiming to verify whether, and to which extent, Italian judges are sensitive to the suggestions of the economic analysis of law (EAL), the two authors update their account and try to strike a first, interlocutory balance. The comment of four new, and so far unpublished judicial opinions concerning the areas of contracts, torts and property rights offers the opportunity to draw some further insights about the effects - positive, not only from the judicial standpoint - stemming from the confrontation between judges and the economic analysis of (private) law.

Published
2005

43. Use of subcutaneous tocilizumab in patients with COVID‐19 pneumonia.

Author

Mazzitelli, Maria, Arrighi, Eugenio, Serapide, Francesca, Pelle, Maria Chiara, Tassone, Bruno, Lionello, Rosaria, Marrazzo, Giuseppina, Laganà, Domenico, Costanzo, Francesco Saverio, Matera, Giovanni, Trecarichi, Enrico Maria, and Torti, Carlo

Subjects
COVID-19, TOCILIZUMAB, PNEUMONIA, CHEST X rays, COVID-19 treatment
Abstract

Di Giambenedetto et al.1 described their experience with intravenous tocilizumab (TCZ) in treating severe coronavirus disease 2019 (COVID-19). We have treated three patients with this drug at a single dose of 162 mg given subcutaneously, in line with data showing similar efficacy compared to intravenously given TCZ for different diseases.6 Treatment course for these patients is described below. In particular, since SC TCZ was not administered further for rapid improvement of patient conditions, this suggest the possibility of reducing the dosage of TCZ, at least in patients with less severe COVID-19. [Extracted from the article]

Published
2021
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47. The three facets of the SARS-CoV-2 pandemic during the first two waves in the northern, central, and southern Italy

Author

Silvio Buscemi, Chiara Davoli, Enrico Maria Trecarichi, Helen Linda Morrone, Bruno Tassone, Carola Buscemi, Cristiana Randazzo, Anna Maria Barile, Piero Colombrita, Maurizio Soresi, Lydia Giannitrapani, Antonio Cascio, Nicola Scichilone, Carlo Cottone, Paolo Sbraccia, Valeria Guglielmi, Frida Leonetti, Alexis Elias Malavazos, Sara Basilico, Michele Carruba, Ferruccio Santini, Alessandro Antonelli, Nicola Viola, Marcello Romano, Bruno Mario Cesana, Carlo Torti, Buscemi, Silvio, Davoli, Chiara, Trecarichi, Enrico Maria, Morrone, Helen Linda, Tassone, Bruno, Buscemi, Carola, Randazzo, Cristiana, Barile, Anna Maria, Colombrita, Piero, Soresi, Maurizio, Giannitrapani, Lydia, Cascio, Antonio, Scichilone, Nicola, Cottone, Carlo, Sbraccia, Paolo, Guglielmi, Valeria, Leonetti, Frida, Malavazos, Alexis Elia, Basilico, Sara, Carruba, Michele, Santini, Ferruccio, Antonelli, Alessandro, Viola, Nicola, Romano, Marcello, Cesana, Bruno Mario, and Torti, Carlo

Subjects
COVID-19, Epidemiology, Italy, Mortality, Public health, SARS-CoV-2, Infectious Diseases, Settore MED/09 - Medicina Interna, Public Health, Environmental and Occupational Health, General Medicine, Settore MED/49 - Scienze Tecniche Dietetiche Applicate, Settore MED/13 - Endocrinologia
Abstract

Background: There is a scarcity of information in literature regarding the clinical differences and comorbidities of patients affected by Coronavirus disease 2019 (COVID-19), which could clarify the different prevalence of the outcomes (composite and only death) between several Italian regions. Objective: This study aimed to assess the heterogeneity of clinical features of patients with COVID-19 upon hospital admission and disease outcomes in the northern, central, and southern Italian regions. Methods: An observational cohort multicenter retrospective study including 1210 patients who were admitted for COVID-19 in Infectious diseases, Pulmonology, Endocrinology, Geriatrics and Internal Medicine Units in Italian cities stratified between north (263 patients); center (320 patients); and south (627 patients), during the first and second pandemic waves of SARS-CoV-2 (from February 1, 2020 to January 31, 2021). The data, obtained from clinical charts and collected in a single database, comprehended demographic characteristics, comorbidities, hospital and home pharmacological therapies, oxygen therapy, laboratory values, discharge, death and Intensive care Unit (ICU) transfer. Death or ICU transfer were defined as composite outcomes. Results: Male patients were more frequent in the northern Italian region than in the central and southern regions. Diabetes mellitus, arterial hypertension, chronic pulmonary and chronic kidney diseases were the comorbidities more frequent in the southern region; cancer, heart failure, stroke and atrial fibrillation were more frequent in the central region. The prevalence of the composite outcome was recorded more frequently in the southern region. Multivariable analysis showed a direct association between the combined event and age, ischemic cardiac disease, and chronic kidney disease, in addition to the geographical area. Conclusions: Statistically significant heterogeneity was observed in patients with COVID-19 characteristics at admission and outcomes from northern to southern Italy. The higher frequency of ICU transfer and death in the southern region may depend on the wider hospital admission of frail patients for the availability of more beds since the burden of COVID-19 on the healthcare system was less intense in southern region. In any case, predictive analysis of clinical outcomes should consider that the geographical differences that may reflect clinical differences in patient characteristics, are also related to access to health-care facilities and care modalities. Overall, the present results caution against generalizability of prognostic scores in COVID-19 patients derived from hospital cohorts in different settings.

Published
2023

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