40 results on '"Tanik C"'
Search Results
2. Primary T-lymphoma of the breast with bilateral involvement, unusual presentation
- Author
-
Kebudi, A., primary, Coban, A., additional, Yetkin, G., additional, Tanik, C., additional, Uludag, M., additional, Akgun, I., additional, and Isgor, A., additional
- Published
- 2005
- Full Text
- View/download PDF
3. Impact of sorafenib on epidural fibrosis: An immunohistochemical study
- Author
-
Omur Gunaldi, Ilhan Yilmaz, Metehan Eseoğlu, Uzay Erdogan, Osman Tanriverdi, Ayca Arslanhan, Huseyin Utku Adilay, Canan Tanik, Tıp Fakültesi, Tanriverdi, Osman, Erdogan, Uzay, Gunaldi, Omur Univ Hlth Sci, Bakirky Prof Dr Mazhar Osman Training & Res Hosp, Dept Neurosurg & Psychiat, Tevfik Saglam Cad 1, TR-34303 Istanbul, Turkey, Tanik, Canan Univ Hlth Sci, Sisli Hamidiye Etfal Training & Res Hosp, Dept Pathol, TR-34303 Istanbul, Turkey, Yilmaz, Ilhan Univ Hlth Sci, Sisli Hamidiye Etfal Training & Res Hosp, Dept Neurosurg, TR-34303 Istanbul, Turkey, Adilay, Huseyin Utku Balikesir Univ, Med Fac, Dept Neurosurg, TR-31300 Balikesir, Turkey, Arslanhan, Ayca Marmara Univ, Inst Neurol Sci, TR-34303 Istanbul, Turkey, Eseoglu, Metehan Medipol Univ, Med Fac, Dept Neurosurg, TR-34303 Istanbul, Turkey, Tanriverdi, O., Department of Neurosurgery and Psychiatry, University of Health Sciences, Bakirky Prof. Dr. Mazhar Osman Training and Research Hospital for Neurology, Istanbul, 34303, Turkey, Erdogan, U., Department of Neurosurgery and Psychiatry, University of Health Sciences, Bakirky Prof. Dr. Mazhar Osman Training and Research Hospital for Neurology, Istanbul, 34303, Turkey, Tanik, C., Department of Pathology, University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital, Istanbul, 34303, Turkey, Yilmaz, I., Department of Neurosurgery, University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital, Istanbul, 34303, Turkey, Gunaldi, O., Department of Neurosurgery and Psychiatry, University of Health Sciences, Bakirky Prof. Dr. Mazhar Osman Training and Research Hospital for Neurology, Istanbul, 34303, Turkey, Adilay, H.U., Department of Neurosurgery, Medical Faculty, Balikesir University, Balikesir, 31300, Turkey, Arslanhan, A., Institute of Neurological Science, Marmara University, Istanbul, 34303, Turkey, and Eseoglu, M., Department of Neurosurgery, Medical Faculty, Medipol University, Istanbul, 34303, Turkey
- Subjects
Sorafenib ,Pathology ,medicine.medical_specialty ,medicine.medical_treatment ,Neovascularization ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Fibrosis ,medicine ,Osteopontin ,biology ,business.industry ,Vascular Endothelial Growth Factor ,Laminectomy ,General Medicine ,Basic Study ,medicine.disease ,Staining ,Vascular endothelial growth factor ,CD105 ,Spinal Epidural Fibrosis ,chemistry ,030220 oncology & carcinogenesis ,biology.protein ,Immunohistochemistry ,medicine.symptom ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Adilay, Hüseyin Utku (Balikesir Author), AIM To determine if sorafenib, an antineoplastic agent, could prevent the development of spinal epidural fibrosis (EF). METHODS The study used CD105 and osteopontin antibodies in an immunohistochemical approach to quantify EF that occurred as a consequence of laminectomy in rats. Wistar albino rats (n = 16) were divided into two groups: control (L1-2 level laminectomy only) and sorafenib treatment (L1-2 level laminectomy + topical sorafenib). The animals were euthanatized after 6 wk, and the EF tissues were examined for histopathological changes after immunohistochemical staining. The EF grades were assigned to the tissues, and the treatment and control groups were compared. RESULTS The EF thickness, inflammatory cell density, and arachnoid adherences determined by light microscopy were significantly higher in the control group compared to the sorafenib-treated group. Based on fibrosis scores, the extent of EF in the treatment group was significantly lower than in the controls. Immunohistochemical staining for CD105 to identify microvessels revealed that the EF grades based on vessel count were significantly lower in the treatment group. Staining for osteopontin did not show any significant differences between the groups in terms of the extent of EF. The staging of EF based on vascular counts observed after immunohistochemical staining for CD105, but not for osteopontin, was compatible with conventional staging methods. Neither toxic effects on tissues nor systemic side effects were observed with the use of sorafenib. CONCLUSION Local administration of sorafenib significantly reduced post-laminectomy EF. Decreased neovascularization in spinal tissue may be due to the sorafenib-induced inhibition of vascular endothelial growth factor.
- Published
- 2018
4. Predictive role of magnetic resonance imaging in the distinction of isocitrate dehydrogenase (IDH) mutant grade 4 astrocytomas versus glioblastomas.
- Author
-
Halefoglu AM, Camurcuoglu E, Tanik C, Kizilkaya O, and Yilmaz A
- Subjects
- Humans, Isocitrate Dehydrogenase genetics, Retrospective Studies, Magnetic Resonance Imaging methods, Brain Neoplasms diagnostic imaging, Brain Neoplasms genetics, Brain Neoplasms pathology, Glioblastoma diagnostic imaging, Glioblastoma genetics, Glioma pathology
- Abstract
Background: Isocitrate dehydrogenase (IDH) mutation status is a crucial prognostic factor in high-grade glial tumors., Purpose: To investigate whether magnetic resonance imaging (MRI) features can display a diagnostic performance in the determination of IDH mutation in high-grade gliomas., Material and Methods: A total of 170 patients including 24 IDH mutant grade 4 astrocytomas and 146 glioblastomas (GBM) were retrospectively examined via contrast-enhanced (CE) MRI before surgery. Immunohistochemistry and genomic sequence analyses were performed on specimen materials for the determination of IDH mutational status. Certain morphological and diffusion-weighted imaging (DWI) parameters were utilized to see if they could play a role to be non-invasive potential imaging predictors in the discrimination of IDH mutant versus wild-type (WT) high-grade gliomas., Results: On histopathological examination, IDH mutation was detected in 24 patients with high-grade glioma and 146 of the patients were found to be WT. Certain morphological criteria of tumor location and involvement, tumor margins, visual detection of diffusion restriction on DWI, and quantitative apparent diffusion coefficient (ADC) parameters consisting of ADC
mean , ADCmin , and ADCr could be used as imaging predictors in the discrimination of high-grade IDH mutant versus WT tumors., Conclusion: Certain MRI morphologic features and visual detection of diffusion restriction on DWI and quantitative ADC parameters consisting of ADCmean , ADCmin , and ADCr can be considered non-invasive, significant independent imaging predictors in the discrimination and can obviate invasive procedures for histopathological diagnosis.- Published
- 2023
- Full Text
- View/download PDF
5. Low-Grade Injury following Testicular Torsion: A Multicenter Study Confirming a Disturbing Possibility.
- Author
-
Cigsar Kuzu EB, Tiryaki S, Guney N, Polatdemir K, Cakir Y, Karagozlu Akgul A, Toper MH, Karaguzel G, Ucar M, Bassorgun CI, Ozel SK, Ozkanli S, Salci G, Aydin Mungan S, Yilmaz MU, Aytac Vuruskan B, Yagmur I, Tarini EZ, Kaba M, Tanik C, Canbaz FA, Hurdogan O, User IR, Orhan D, Atici A, Gursoy D, Yagmurlu EA, Enneli D, Kilic SS, and Erdogan S
- Subjects
- Male, Humans, Retrospective Studies, Testis surgery, Testis blood supply, Orchiectomy, Orchiopexy, Spermatic Cord Torsion surgery, Spermatic Cord Torsion diagnosis
- Abstract
Introduction: There is an ongoing debate whether to perform orchiectomy or orchidopexy following testicular torsion (TT) in cases where the testis seems non-viable. The main problem is lack of objective criteria defining testicular viability. The aim of this study was to investigate the grade of injury in orchiectomy specimens obtained from cases of TT and its association with clinical findings., Methods: This multicenter retrospective study involved double-blinded reassessment of the patient files and the pathological specimens using Mikuz classification to analyze the relation between clinical and pathological findings., Results: A total of 289 patient charts from 14 centers were reviewed and 228 were included in this study. Twenty (8.8%) patients had grade 1 injury which refers to reversible injury. The clinical findings of these 20 patients were compared to 208 patients with higher grades of injury. As expected, there was statistically significant difference regarding duration of symptoms (p < 0.001); however, range was wide in both groups (as long as 96 h for grade 1 and as short as 7 h for higher grades). There was no statistically significant difference in any other variable including age (median 14 for both, p = 0.531), symptoms (pain: 19/20 vs. 189/202, p = 0.801; swelling: 13/19 vs. 168/197, p = 0.094), absence of blood flow in Doppler US (15/19 vs. 164/197, p = 0.635), or degree of torsion (median 720° for both, p = 0.172)., Conclusion: Our study revealed necessity for better criteria to define viability of testis following TT. Histopathological injury appeared to be reversible even in some patients with more severe perioperative findings, late admission, or high degree of twisting. Our findings support the tendency for testicular fixation instead of orchiectomy as none of the clinical or perioperative findings could be attributed to high-grade injury., (© 2023 S. Karger AG, Basel.)
- Published
- 2023
- Full Text
- View/download PDF
6. Relationships between androgen receptor expression and clinicopathological parameters in male breast cancer.
- Author
-
Uçak R, Tanik C, Kaya C, Bozkurt E, and Kabukçuoğlu F
- Abstract
Introduction: Most patients with male breast cancer (MBC) express the androgen receptor (AR). AR expression in these tumors may have both prognostic and predictive values because its presence indicates the potential benefits of an anti-androgen therapeutic approach. The present study aimed to investigate the relationship between AR expression and clinicopathological parameters in MBC., Material and Methods: The data of 35 patients who received a histological diagnosis of MBC at the pathology department of our hospital between January 2007 and December 2017 were retrospectively reviewed. The patientsħ demographic data, follow-up records and pathology reports were recorded. AR expression status and its relationship with clinicopathological parameters were evaluated. The chi-square test was used to compare independent groups. Univariate survival analyses were performed using the Kaplan–Meier survival procedure. A p value of ≤0.05 was considered statistically significant., Results: There was no significant relationship between AR expression and AJCC stage (p=0.585), pathologic stage (p=0.696), histologic grade (p=0.685), lymph-node status (p=0.685), survival rate (p=1.000), age(p=1.000), lymphovascular invasion (p=0.700), perineural invasion(p=1.000), skin invasion (p=1.000), nipple involvement(p=1.000), DCIS presence(p=1.000), ER positivity(p=1.000), PR positivity (p=0.218), Her2 expression (p=0.523), Ki67 index (p=0.685), Luminal A group (p=0.700), Luminal B group (p=0.691), triple negative group (p=1.000)., Conclusion: Further investigation of the relation between AR expression and clinicopathological parameters of patients with MBC might yield important information and lead to the development of additional treatment options., Key Words: Androgen receptor, AR expression, breast cancer, Male Breast cancer, Prognosis, Receptor status
- Published
- 2022
7. Recurrent Solitary Fibrous Tumor in Intradural Extramedullary Space: Case Report and Review of the Literature.
- Author
-
Dincer N, Bagci M, Figen M, Yilmaz A, Halefoglu AM, Tanik C, and Uzel EK
- Abstract
Solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a rare neoplasm arising from spindle cells and most commonly arising from pleura. Spinal SFT/HPC is a rare entity; hence, it is not on the top of the differential diagnosis list when a clinician faces a spinal lesion. In the review of the literature, there exist less than 50 case reports of intradural extramedullary SFT/HPC. Here, we present a 54-year-old female patient who underwent subtotal surgical excision of an intradural extramedullary spinal mass pathologically reported to be SFT/HPC and had symptomatic recurrence in the 3
rd year of follow-up. Surgical intervention was unachievable and the patient was given 45 Gy to the surgical cavity followed by a 5.4 Gy boost to visible tumor with external radiotherapy. Patient reported significant relief of her symptoms. We aim to contribute to the formation of a treatment algorithm for this rare entity., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2021 Neris Dincer et al.)- Published
- 2021
- Full Text
- View/download PDF
8. Evaluation of Human Epidermal Growth Factor Receptor 2 Overexpression, Clinicopathological Characteristics, and Factors Affecting Survival in Gastric Cancer.
- Author
-
Celayir OM, Selcukbiricik F, Tanik C, and Altuntas Y
- Abstract
Objectives: The objective of the study was to evaluate the human epidermal growth factor receptor 2 (HER2) overexpression, clinicopathological features, and factors affecting survival in patients with gastric cancer., Methods: The study is a retrospective study conducted with 128 cases of gastric cancer who were admitted to Şişli Hamidiye Etfal Training and Research Hospital between 2005 and 2012. Patients' demographic characteristics, performance score, tumor localization, information about surgery, HER2 measurements, histopathological characteristics, stage, treatment features, metastasis sites, and overall survival time were obtained from medical records. Immunohistochemical analysis was performed for HER2 scoring., Results: There were 89 (69.5%) men and 39 (30.5%) women in the study group, and the median age of the patients was 64 years. The median survival time of the patients was 24.43 months. The survival rate of the patients was calculated as 35.4±5.9%. Overall survival time was found to be shorter in the group with higher HER2 levels and also those with advanced-stage cancer. The survival rate was found to be significantly lower in patients with perineural invasion and advanced stage. However, the survival rate was not associated with lymphovascular invasion, surgical margin involvement, and HER2 levels. In the multivariate Cox Regression analysis performed to assess the effects of gender, histological subtype, stage, and surgical margin on overall survival, disease stage was found to be the only factor effective on survival. Gender, histological subtype, and the surgical margin did not affect prognosis., Conclusion: The survival rate in gastric cancers was found to be lower in those with advanced-stage disease. Higher HER2 level and the disease stage were associated with shorter overall survival time., Competing Interests: Conflict of Interest: None declared., (Copyright: © 2021 by The Medical Bulletin of Sisli Etfal Hospital.)
- Published
- 2021
- Full Text
- View/download PDF
9. Inadvertent Error: Evaluation of Bevacizumab for the Treatment of Epidural Fibrosis by Immunohistochemical Staining for CD105 and Osteopontin.
- Author
-
Yilmaz I, Erdogan U, Tanriverdi O, Gunaldi O, Adilay HU, Omeroglu M, Tanik C, and Tugcu B
- Published
- 2021
- Full Text
- View/download PDF
10. Male Breast Cancer with Radiological and Histopathological Findings.
- Author
-
Sahin C, Ucpinar BA, Mut DT, Yilmaz O, Ucak R, Kaya C, and Tanik C
- Abstract
Objectives: We aimed to remind and emphasize the importance of male breast cancer with radiological and histopathological results of the patients diagnosed in our institution., Methods: Men who had proven breast cancer by histopathological analysis between February 2010-April 2018 were reviewed retrospectively. The mammographic, ultrasonographic, magnetic resonance and positron-emission-tomography imaging features and histopathological results of the masses were noted., Results: Twenty-five men were included in this study. Mean age of the patients was 62.9 (min:42; max: 82) with a mean size of lesions was 26.4 mm (min:10 mm; max: 70 mm). All the lesions were presented as a palpable mass. According to imaging features of the five patients who had mammography, all the four patients were presented as a mass but one patient as asymmetrical density. According to imaging features of the 20 patients who had an ultrasound, 16 (80%) lesions were presented as hypoechoic solid masses with irregular margins, while four (20%) were presented as complex-cystic masses with irregular margins. All the patients were diagnosed as invasive ductal cancer with luminal subtype by histopathological analysis., Conclusion: Even at young ages, the palpable lesion may be the only symptom of male breast cancer. Male breast cancer is generally presented as retroareolar mass and detected in advanced stages, probably due to low awareness and lack of screening programme. Invasive ductal cancer is the most common type of male breast cancer with the luminal subtype., Competing Interests: Conflict of Interest: None declared., (Copyright: © 2019 by The Medical Bulletin of Sisli Etfal Hospital.)
- Published
- 2020
- Full Text
- View/download PDF
11. Pseudoangiomatous stromal hyperplasia causing severe breast enlargement in a 15-year-old girl: A case report.
- Author
-
Yigit B, Citgez B, Celayir MF, Yetkin S, Tanik C, and Mihmanli M
- Subjects
- Adolescent, Breast diagnostic imaging, Breast pathology, Breast surgery, Female, Humans, Hyperplasia pathology, Angiomatosis diagnosis, Angiomatosis pathology, Angiomatosis surgery, Breast Diseases diagnosis, Breast Diseases surgery
- Abstract
Pseudoangiomatous stromal hyperplasia (PASH), composed of proliferated stromal mesenchymal cells of myofibroblastic origin, is a benign lesion of the breast. A few cases associated with pseudoangiomatous stromal hyperplasia of the breast have been reported. We report this case of a 15-year-old girl with PASH accompanied by severe enlargement and painful mass in the right breast. There were no other palpable masses or lymph nodes. Biopsy of the mass showed histopathologic features characteristic of fibroadenoma. The palpable mass was around 6x5cm in diameter, while clinical manifestations aroused suspicion of malignancy mimicking sarcoma of the breast. Although, biopsy of the mass showed benign histopathologic features; surgical excision was performed because of the damage caused by enlarging breast tissue and clinical suspicion of malignancy.
- Published
- 2020
- Full Text
- View/download PDF
12. Intraoperative Imprint-squash Methods in Central Nervous System Tumors.
- Author
-
Tanik C and Kabukcuoglu F
- Abstract
Objectives: Central nervous system (CNS) tumors constitute 1.3% of all cancers in adults and are the seventh leading cause of death in developed countries. CNS tumors are very soft and have a gelatin-like texture. Smear technique is a very simple and fast method for the diagnosis of brain tumors., Methods: In this study, we evaluated the imprint and squash cytology of 100 cases sent to the pathology clinic. The sections of the paraffin blocks were prepared after the operation in the neurosurgery clinic of the SBU Hamidiye Şişli Efal Training and Research Hospital. The accuracy rate was 90% in the differential diagnosis of malignant tumors from the benign ones., Conclusion: Cytological samples were taken from 100 cases of intracranial tumors that were operated in the neurosurgery clinic of Şişli Etfal Hospital, and the paraffin sections prepared from the biopsy materials were examined. The cases with misdiagnosis were usually differentiated from solid-hard tumors, epithelial-grade cystic structures, and medulloblastoma localized in the posterior fossa, medulloblastoma and ependymoma. However, this method has been found to be very convenient in practice due to its ease technically, low cost and equipment savings., Competing Interests: Conflict of Interest: None declared., (Copyright: © 2020 by The Medical Bulletin of Sisli Etfal Hospital.)
- Published
- 2020
- Full Text
- View/download PDF
13. The protective effects of sesamol in a neonatal rat model of necrotizing enterocolitis.
- Author
-
Cigsar EB, Karadag CA, Tanik C, Aydin AF, and Dokucu AI
- Subjects
- Administration, Oral, Animals, Animals, Newborn, Biomarkers metabolism, Enterocolitis, Necrotizing metabolism, Enterocolitis, Necrotizing pathology, Injections, Intraperitoneal, Intestinal Mucosa metabolism, Intestinal Mucosa pathology, Random Allocation, Rats, Rats, Wistar, Severity of Illness Index, Treatment Outcome, Anti-Inflammatory Agents therapeutic use, Antioxidants therapeutic use, Benzodioxoles therapeutic use, Enterocolitis, Necrotizing drug therapy, Phenols therapeutic use, Protective Agents therapeutic use
- Abstract
Background and aim: Necrotizing enterocolitis (NEC) is a severe gastrointestinal inflammatory disease associated with high rates of morbidity and mortality. Its pathophysiology includes hypoxic-ischemic injury that may be related to oxygen-derived free radical formation. Sesamol is considered to be an antioxidant and free radical scavenger with anti-inflammatory effects. The aim of this study is to investigate the effects of sesamol in a neonatal rat model of NEC. Materials and methods: The study included 1-day-old Wistar albino rat pups ( n = 34) that were randomly divided into four groups: Group 1 (NEC), group 2 (NEC + intraperitoneal sesamol), group 3 (NEC + oral sesamol), and a control group. NEC was induced by exposure to hypoxia/reoxygenation, following cold stress and hyperosmolar enteral formula feeding. Sesamol 100 mg kg
-1 dose-1 was administered intraperitoneally to group 2 and orally to group 3 for 3 days. On day 4 all rats were sacrificed. Histological injuries, the Bcl-2, caspase-3, malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione-peroxidase (GSH-Px) activities were measured in intestinal samples. Results: The grade of intestinal damage, and Bcl-2 and caspase-3 levels in group 1 were significantly higher than in groups 2 and 3 and the control group, and intestinal damage was significantly more severe in group 1 than in groups 2 and 3. The MDA activity was significantly lower in groups 2 and 3 than in group 1 (112, 89, and 144 nmol mL-1 , respectively). Groups 2 and 3 had significantly higher SOD and GSH-Px activities than group 1 (SOD: 1.75, 1.74, and 0.89 U mg-1 ; GSH-Px: 114, 121, and 110 nmol of NADPH min-1 mg-1 , respectively). Conclusions: The present findings highlight that sesamol has beneficial effects on intestinal injury in a rat model of NEC through its antioxidant and anti-inflammatory properties.- Published
- 2020
- Full Text
- View/download PDF
14. Male breast cancer: A 10 year retrospective case series in a tertiary care hospital.
- Author
-
Yetkin G, Celayir MF, Tanik C, Citgez B, Uludag M, and Mihmanli M
- Subjects
- Aged, Antineoplastic Agents, Hormonal therapeutic use, Axilla, Breast Neoplasms, Male metabolism, Breast Neoplasms, Male therapy, Carcinoma, Ductal, Breast metabolism, Carcinoma, Ductal, Breast therapy, Carcinoma, Intraductal, Noninfiltrating metabolism, Carcinoma, Intraductal, Noninfiltrating therapy, Chemotherapy, Adjuvant, Humans, Lymph Node Excision, Male, Mastectomy, Mastectomy, Modified Radical, Middle Aged, Neoplasm Staging, Prognosis, Proportional Hazards Models, Radiotherapy, Adjuvant, Receptor, ErbB-2 metabolism, Receptors, Estrogen metabolism, Receptors, Progesterone metabolism, Retrospective Studies, Sentinel Lymph Node Biopsy, Survival Rate, Tertiary Care Centers, Tumor Burden, Turkey, Breast Neoplasms, Male pathology, Carcinoma, Ductal, Breast pathology, Carcinoma, Intraductal, Noninfiltrating pathology, Lymph Nodes pathology
- Abstract
Male breast cancer is a rare disease and it differs from breast cancer in women by some characteristics. The incidence of the disease has increased in the last 25 years. The records of male patients who underwent surgery for breast cancer between 2007 and 2017 were retrospectively reviewed in a tertiary care hospital in Istanbul, Turkey. The patients' ages, background, family history, clinical features, histopathological features of the tumour, its stage, the treatment and the survival were investigated. SPSS 15.0 for Windows programme was used for statistical analysis.Survival analysis was performed with Kaplan-Meier method.Determinants were analysed by univariate Cox regression analysis. A total of 15 patients were evaluated in our study. Fourteen patients had invasive ductal carcinoma and one patient had intraductal papillary carcinoma. The median followup period of the patients was 36 months The axillary lymph node metastasis positivity rate (number of metastatic lymph nodes/number of lymph nodes dissected) was statistically significantly higher in patients who died than in patients who survived.In univariate Cox regression analysis, the effects of age, tumour size, estrogen, progesterone, the presence of HER2/neu receptor and axillary metastasis on survival were not determined. We believe that raising awareness on male breast cancer in the community, genetic testing and screening mammography in high-risk patients will be useful in early diagnosis of the disease and improvement of its prognosis.
- Published
- 2019
15. Immunohistochemical Grading of Epidural Fibrosis with CD105 Antibody.
- Author
-
Erdogan U, Tanik C, Tanriverdi O, Gunaldi O, Yilmaz I, Arslanhan A, and Ofluoglu AE
- Subjects
- Animals, Biomarkers metabolism, Epidural Space pathology, Fibroblasts pathology, Fibrosis pathology, Immunohistochemistry, Laminectomy adverse effects, Lumbar Vertebrae surgery, Microvessels pathology, Neovascularization, Pathologic, Postoperative Complications pathology, Rats, Wistar, Antibodies, Monoclonal metabolism, Antifibrinolytic Agents pharmacology, Endoglin immunology, Tranexamic Acid pharmacokinetics
- Abstract
Objective: Grading of epidural fibrosis (EF) is usually performed by histopathologic staining in experimental studies. Immunohistochemical methods for grading are not available in routine practice yet. In our study, the effect of tranexamic acid (TXA), a commonly used hemostatic agent in surgical interventions, was evaluated for use against the development of EF with classical histopathologic methods and immunohistochemistry using the CD105 antibody, a marker of angiogenesis., Methods: Sixteen rats were used. The rats were assigned to 2 groups, control and TXA. Laminectomy was performed on the control group. In the treatment group, laminectomy + topical TXA was applied. After sacrificing the rats in the sixth week, histopathologic and immunohistochemical examinations and grading of the EF tissue were performed., Results: Conventional histopathologic parameters of fibroblast count, intensity of fibrosis density, and inflammatory cell density, as well as immunohistochemical evaluation with CD105, showed that the grading of EF was comparable between groups I and II (P < 0.001)., Discussion: The results of our study have demonstrated that CD105 is compatible with the conventional histopathologic grading methods and can be used as a marker to determine the grades of angiogenesis and fibrosis in experimental studies. The results of our study have also shown that TXA, administered locally for hemostasis, reduces the grade of EF in rats following laminectomy. TXA has been observed to cause no toxic effects on neural tissue as it is already commonly used in clinical practice., (Copyright © 2019. Published by Elsevier Inc.)
- Published
- 2019
- Full Text
- View/download PDF
16. Management of Craniopharyngioma.
- Author
-
Kiliç M, Can SM, Özdemir B, and Tanik C
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Female, Humans, Male, Middle Aged, Retrospective Studies, Young Adult, Craniopharyngioma epidemiology, Craniopharyngioma surgery
- Abstract
Objective: Craniopharyngiomas are one of the most challenging problems for neurosurgeons because of the high recurrence rates due to their localization and associated endocrinological disorders. This study reports the outcomes of surgeries and recurrence rates of 45 craniopharyngioma cases., Method: Patients who were diagnosed with craniopharyngioma in the authors' clinic between 1998 and 2016 evaluated retrospectively., Results: A total of 45 patients (25 males and 20 females; age, 3-56 years) who had previously undergone surgery for craniopharyngioma were enrolled and followed up for 12 to 222 months (mean follow-up duration, 73.5 ± 55.2 months). Among these, 25 were children (55.5%) with a mean age of 9.5 ± 4.6 years and 20 were adults (45.5%) with a mean age of 37.2 ± 12.7 years. A total of 39 (86.6%) patients underwent total tumor resection, while 6 (13.4%) underwent subtotal tumor removal. During 12 to 30 months of follow-up, the progression of residual tumor was recorded in 4 patients, 3 of whom underwent surgery and postoperative radiotherapy. Despite the total resection of tumor in their first surgery, 3 patients showed tumor recurrence during 15 to 34 months of the follow-up., Conclusion: Our findings suggest that the total resection of craniopharyngiomas, when possible, results in a favorable quality of life, with acceptable mortality and morbidity rates.
- Published
- 2019
- Full Text
- View/download PDF
17. Effect of Cetuximab on the Development of Epidural Fibrosis Based on CD105 and Osteopontin Immunohistochemical Staining.
- Author
-
Tanriverdi O, Yilmaz İ, Adilay HU, Gunaldi O, Erdogan U, Gungor A, Kilic M, and Tanik C
- Subjects
- Animals, Disease Models, Animal, Endoglin metabolism, Epidural Space chemistry, Epidural Space metabolism, Failed Back Surgery Syndrome, Immunohistochemistry, Laminectomy adverse effects, Osteopontin metabolism, Rats, Rats, Wistar, Cetuximab pharmacology, Cetuximab therapeutic use, Endoglin analysis, Epidural Space drug effects, Fibrosis metabolism, Osteopontin analysis
- Abstract
Study Design: The effect of cetuximab on the development of epidural fibrosis (EF) was assessed using immunohistochemical methods as well as antibodies for CD105 and osteopontin (OPN)., Objective: The goal of this study was to assess of EGFR inhibition for the postoperative treatment of fibrosis., Summary of Background Data: EF is one of most common causes of failed back surgery syndrome, which occurs after laminectomy. Numerous causes and mechanisms have been proposed to explain its development after laminectomy. Many agents have been tested to prevent the development of EF. EGFR, a multi-functional transmembrane glycoprotein, causes cell growth, proliferation, and EF by interacting with epidermal growth factor and TGF-β1. The inhibition of postoperative fibrosis using cetuximab, an epidermal growth factor receptor blocker, is theoretically possible. However, this has not been tested to date., Methods: Sixteen Wistar-Albino rats were divided into two groups, namely, control and cetuximab groups. L1-2 laminectomy alone was performed in both groups, and topical cetuximab was applied to the treatment group. After 6 weeks, rats were sacrificed and examined histopathologically and immunohistochemically; EF tissue was also graded. Statistical significance was accepted at P < 0.05., Results: Fibroblast counts and fibrosis density, determined by histopathologic examination, and EF, according to immunohistochemical assessment based on CD105, were found to be higher in the treatment group than in the control group, and this was statistically significant (P < 0.001). Based on OPN staining, the results were consistent with classical methods, and no significant difference was detected among the groups (P = 0.358)., Conclusion: Our study revealed that cetuximab inhibits the development of EF and that CD105, and not OPN, is a reliable marker for grading EF. In addition, cetuximab did not result in toxic, systemic side effects in surrounding tissues., Level of Evidence: N/A.
- Published
- 2019
- Full Text
- View/download PDF
18. Solitary Extramedullary Plasmacytoma Mimicking Acute Subdural Hematoma.
- Author
-
Ozoner B, Aydin AL, Aydin S, Tanik C, Uyanoglu A, and Musluman AM
- Subjects
- Brain Neoplasms pathology, Brain Neoplasms surgery, Craniotomy, Diagnosis, Differential, Female, Headache, Humans, Middle Aged, Neurosurgical Procedures, Paresis, Plasmacytoma pathology, Plasmacytoma surgery, Radiotherapy, Adjuvant, Tomography, X-Ray Computed, Unconsciousness, Vomiting, Brain Neoplasms diagnostic imaging, Craniocerebral Trauma diagnostic imaging, Hematoma, Subdural, Acute diagnostic imaging, Plasmacytoma diagnostic imaging
- Abstract
Background: Solitary extramedullary plasmacytoma (SEP) is a plasma cell neoplasm located outside the bone. It is rarely observed in the intracranial area. It is very difficult to diagnose this condition radiologically before surgery. In addition, dural SEP is usually misdiagnosed., Case Description: We report a case of plasmacytoma that presented as altered mental status after head trauma, located in the subdural area. We also describe its differential diagnosis and treatment by total removal and adjuvant radiotherapy. The 66-month follow-up findings showed distant plasmacytoma development, which was treated with radiotherapy alone., Conclusions: Some pathological entities should be considered in the differential diagnosis of acute subdural hematomas. Furthermore, to the best of our knowledge, we report the first case of dural SEP mimicking acute subdural hematoma., (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
19. Impact of sorafenib on epidural fibrosis: An immunohistochemical study.
- Author
-
Tanriverdi O, Erdogan U, Tanik C, Yilmaz I, Gunaldi O, Adilay HU, Arslanhan A, and Eseoglu M
- Abstract
Aim: To determine if sorafenib, an antineoplastic agent, could prevent the development of spinal epidural fibrosis (EF)., Methods: The study used CD105 and osteopontin antibodies in an immunohistochemical approach to quantify EF that occurred as a consequence of laminectomy in rats. Wistar albino rats ( n = 16) were divided into two groups: control (L1-2 level laminectomy only) and sorafenib treatment (L1-2 level laminectomy + topical sorafenib). The animals were euthanatized after 6 wk, and the EF tissues were examined for histopathological changes after immunohistochemical staining. The EF grades were assigned to the tissues, and the treatment and control groups were compared., Results: The EF thickness, inflammatory cell density, and arachnoid adherences determined by light microscopy were significantly higher in the control group compared to the sorafenib-treated group. Based on fibrosis scores, the extent of EF in the treatment group was significantly lower than in the controls. Immunohistochemical staining for CD105 to identify microvessels revealed that the EF grades based on vessel count were significantly lower in the treatment group. Staining for osteopontin did not show any significant differences between the groups in terms of the extent of EF. The staging of EF based on vascular counts observed after immunohistochemical staining for CD105, but not for osteopontin, was compatible with conventional staging methods. Neither toxic effects on tissues nor systemic side effects were observed with the use of sorafenib., Conclusion: Local administration of sorafenib significantly reduced post-laminectomy EF. Decreased neovascularization in spinal tissue may be due to the sorafenib-induced inhibition of vascular endothelial growth factor., Competing Interests: Conflict-of-interest statement: The authors declare that they have no conflict of interest.
- Published
- 2018
- Full Text
- View/download PDF
20. Evaluation of Bevacizumab for the Treatment of Epidural Fibrosis by Immunohistochemical Staining for CD105 and Osteopontin.
- Author
-
Yilmaz I, Erdogan U, Tanriverdi O, Gunaldi O, Adilay U, Omeroglu M, Tanik C, and Tugcu B
- Subjects
- Animals, Endoglin biosynthesis, Fibrosis pathology, Immunohistochemistry, Male, Osteopontin biosynthesis, Rats, Rats, Wistar, Bevacizumab pharmacology, Biomarkers analysis, Epidural Space drug effects, Epidural Space pathology
- Abstract
Aim: To evaluate bevacizumab for epidural fibrosis (EF) treatment in an experimental rat model using histopathology as well as immunohistochemical staining for CD105 and osteopontin (OPN)., Material and Methods: Sixteen Wistar Albino rats underwent either laminectomy alone to induce EF (group I, control) or laminectomy plus local bevacizumab treatment (group II). The degree of EF was compared between groups using the current histopathological grading method as well as immunohistochemistry for CD105 and OPN. In addition, the consistency of EF staging using CD105 and OPN expression was compared to that using histopathology., Results: The grade of EF was significantly lower in group II than in group I based on the fibroblast count and fibrosis density determined using histopathology, as well as by CD105 expression determined using immunohistochemistry. In contrast, OPN expression was not a reliable marker for EF evaluation because it did not show a significant difference between the two groups., Conclusion: Bevacizumab prevents EF development as assessed using both histopathology and CD105 expression. CD105 is a potentially reliable marker for the immunohistochemical grading of EF, in contrast to OPN.
- Published
- 2018
- Full Text
- View/download PDF
21. Computerized Tomography-Guided Stereotactic Biopsy of Intracranial Lesions: Report of 500 Consecutive Cases.
- Author
-
Can SM, Turkmenoglu ON, Tanik C, Uysal E, Ozoner B, Kaldirimoglu SA, Musluman AM, Yilmaz A, Cavusoglu H, Bayindir C, and Aydin Y
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Biopsy methods, Brain pathology, Brain Diseases pathology, Brain Edema diagnostic imaging, Brain Edema pathology, Brain Edema surgery, Brain Neoplasms diagnostic imaging, Brain Neoplasms pathology, Brain Neoplasms surgery, Child, Child, Preschool, Female, Glioma diagnostic imaging, Glioma pathology, Glioma surgery, Hematoma, Epidural, Cranial diagnostic imaging, Hematoma, Epidural, Cranial pathology, Hematoma, Epidural, Cranial surgery, Humans, Imaging, Three-Dimensional methods, Intracranial Hemorrhages pathology, Male, Middle Aged, Prospective Studies, Young Adult, Brain diagnostic imaging, Brain surgery, Brain Diseases diagnostic imaging, Brain Diseases surgery, Stereotaxic Techniques, Tomography, X-Ray Computed methods
- Abstract
Aim: Computed tomography (CT)-guided stereotactic brain biopsy has been performed in our clinic since March 1998. In this prospective study, we examined the patient data undergoing stereotactic biopsy and the results of biopsies in 500 consecutive patients., Material and Methods: Between the dates of March 1998 and January 2015, CT-guided stereotactic biopsies were performed by using the Leksell stereotactic frame system (Elekta Instruments EU, Sweden) in 500 patients. A total of 512 procedures were performed in patients consisting of 184 females (36.8%) and 316 males (63.2%), ages ranging from 3 to 81 years (mean 50.40±16.67)., Results: Conclusive histopathological diagnosis was not achieved in 17(3.3%) of 512 procedures. Of the others, 173 (33.8%) were high-grade gliomas, 103 (20.1%) were low-grade gliomas, 36 (7%) were malignant lymphomas, 34 (6.6%) were other types of brain tumors, 82 (16%) were metastasis and 67 (13.1%) were non-tumoral lesions. Complications were occurred in ten cases: 3 tumoral bleedings, 2 hypertensive cerebral hematomas, 2 peroperative convulsions, 1 epidural hematoma, 1 myocardial infarction and 1 brain edema. The patients who developed myocardial infarction and hypertensive thalamic hematoma died. The mortality was 0.4% and morbidity was 1.6% in 512 procedures., Conclusion: CT-guided stereotactic biopsy is a reliable and a safe procedure in cases with intracranial lesions when histopathological diagnosis is required for the appropriate treatment.
- Published
- 2017
- Full Text
- View/download PDF
22. Antioxidant Effects of Probiotics in Experimentally Induced Peritonitis.
- Author
-
Erginel B, Aydin FA, Erginel T, Tanik C, Abbasoglu SD, Soysal FG, Keskin E, Celik A, and Salman T
- Subjects
- Animals, Disease Models, Animal, Glutathione analysis, Histocytochemistry, Ileum pathology, Male, Malondialdehyde analysis, Peroxidase analysis, Rats, Wistar, Severity of Illness Index, Antioxidants, Peritonitis pathology, Peritonitis therapy, Probiotics administration & dosage
- Abstract
Aim: An experimental study was performed to evaluate the protective effects of probiotics on gut mucosa in peritonitis through antioxidant mechanisms., Methods: Thirty-two male Wistar albino rats were divided equally into four groups. The rats in Group 1 (control group) underwent laparotomy only. In group 2 (peritonitis group), peritonitis was induced in the rats by the cecal ligation and puncture (CLP) model. In group 3, the rats were treated with probiotics for five days after CLP-induced peritonitis. The last group of rats (group 4) were fed probiotics for five days before the CLP procedure and five days after the surgery. On the fifth day after surgery, all rats were killed, and tissue samples from the terminal ileum were obtained to evaluate the activities of myeloperoxidase (MPO), malondialdehyde (MDA), and glutathione (GSH). Histopathologic examinations were also performed to evaluate the grade of intestinal injury., Results: Myeloperoxidase and MDA activities were increased, GSH concentrations were decreased in group 2, compared with group 1. Intestinal MPO activities in group 4 were decreased compared with group 1 and group 2, indicating a reduction in oxidant activity. Malondialdehyde decreased in group 3 and decreased even more in group 4, compared with the peritonitis group (group 2). Glutathione concentrations were increased in group 4 compared with group 2 and group 3 (p < 0.05). The Chiu scores of the probiotics groups, groups 3 and 4, were lower than those in group 2, indicating reduced mucosal damage in the probiotically fed groups., Conclusion: Probiotics have protective effects in peritonitis, which may be related to antioxidant mechanisms. This antioxidant effect of probiotics might occur when pre-conditioning with probiotics before peritonitis because there is sufficient time to prepare the tissues for oxidative damage.
- Published
- 2016
- Full Text
- View/download PDF
23. Expression of voltage gated potassium channel ether à go-go in pituitary adenomas of patients with acromegaly: A preliminary study.
- Author
-
Zuhur SS, Ozkayalar H, Kuzu I, Ozturk FY, Elbuken G, Tanik C, and Altuntas Y
- Subjects
- Adult, Aged, Growth Hormone-Secreting Pituitary Adenoma pathology, Humans, Ki-67 Antigen metabolism, Male, Middle Aged, Pilot Projects, Young Adult, Ether-A-Go-Go Potassium Channels metabolism, Growth Hormone-Secreting Pituitary Adenoma metabolism
- Abstract
Objective: To determine immunohistochemical expression of Eag1 in pituitary adenomas of patients with acromegaly and to assess the correlation between Eag1 expression with cavernous sinus invasion, tumoral Ki-67 labeling index (LI), age and gender of the patients., Methods: The paraffin embedded pituitary adenoma tissue sections of 28 patients with acromegaly who were diagnosed as monohormonal growth hormone (GH) secreting adenomas were immunostained for Eag1 using the avidin-biotin-peroxidase complex method. Eag1 immunoreactivity was scored according to the extensity of the cytoplasm and cell membrane immunoreactivity for Eag1 (score 1 = <10%, score 2 = 10-25%, score 3 = 25-50% and score 4 = >50% of the adenoma cells showed immunoreactivity for Eag1, respectively)., Results: Overall, GH secreting pituitary adenomas displayed diverse levels of Eag1 immunoreactivity, however, 64% of the adenomas displayed a strong Eag1 immunoreactivity (score 3 and 4). Five of the tumors displayed Eag1 immunoreactivity score 1, 5 displayed score 2, 10 displayed score 3 and 8 displayed score 4, respectively. No correlation was found between Eag1 immunoreactivity with cavernous sinus invasion, Ki-67 LI, age and gender of the patients., Conclusions: Our results suggest Eag1 is strongly expressed in the majority of GH secreting pituitary adenomas. However, we could not find any correlation between immunoreactivity of Eag1 with cavernous sinus invasion, Ki-67 LI, age and gender of the patients. Further studies with larger sample sizes are required to demonstrate the role of Eag1 on tumorigenesis, angiogenesis, invasion and response to the treatment in GH secreting pituitary adenomas.
- Published
- 2015
24. A retrospective review of the adnexal outcome after detorsion in premenarchal girls.
- Author
-
Yildiz A, Erginel B, Akin M, Karadağ CA, Sever N, Tanik C, Canmemiş A, and Dokucu AI
- Subjects
- Adnexal Diseases diagnostic imaging, Adolescent, Biopsy, Child, Child, Preschool, Female, Humans, Ovariectomy, Retrospective Studies, Torsion Abnormality diagnostic imaging, Treatment Outcome, Ultrasonography, Adnexal Diseases surgery, Torsion Abnormality surgery
- Abstract
Background: The aim of this study was to report our results on premenarchal girls with adnexal torsion who were treated with different approaches., Materials and Methods: Twenty-six adnexal torsions in children were analysed retrospectively. Group 1 included cases of oophorectomy for the twisted adnexa. Group 2 contained the patients with adnexal torsion who untwisted either with a laparoscopic or open approach. Postoperative restoration of ovarian function was evaluated by Doppler ultrasound at the 6 th month. All oophorectomy and biopsy specimens were also evaluated., Results: Group 1 consisted of eleven cases that underwent oophorectomy due to gangrenous change and haemorrhagic infarction. Histology was of a mature teratoma in two cases and haemorrhagic necrosis due to torsion in seven. Group 2 consisted of 15 patients. In 10 out of 15 patients, preoperative biopsy is performed in which their histology revealed haemorrhagic necrosis in eight cases, and simple cyst with a benign nature in two cases. In all of the 10 untwisted adnexas, postoperative radiological imaging showed complete recovery with normal follicular development. No malignancy or increased tumour markers were noted in both groups., Conclusion: Adnexas can be left in place regardless of the preoperative degree of necrosis. Biopsy can be added to the procedure to rule out malignancy.
- Published
- 2014
- Full Text
- View/download PDF
25. Primary signet ring cell carcinoma of the lung with cerebellar metastasis showing full response to Cisplatin and docetaxel therapy.
- Author
-
Kocas O, Selcukbiricik F, Bilici A, Kanıtez M, Yildiz S, Avci S, and Tanik C
- Abstract
Introduction. Primary signet ring cell carcinoma (SRCC) of the lung is a very rare disease. We describe a new case of primary SRCC of the lung with cerebellar metastasis, which responded well to the therapeutic approach with cisplatin and docetaxel. Case Report. A 41-year-old female patient (nonsmoker) was consulted to our oncology outpatient clinic after cerebellar metastasectomy. The histopathological diagnosis was SRCC metastasis. The primary tumor was unknown. The PET-CT imaging showed a hypermetabolic mass in the right middle lobe of the lung and hypermetabolic mediastinal lymph node stations. Oesophagogastroduodenoscopy and colonoscopy showed no evidence of gastrointestinal system tumor. The clinical diagnosis of primary SRCC of the lung was made and the administration of six rounds of cisplatin and docetaxel treatment was planned. After the chemotherapy the PET-CT scan to evaluate the therapy response showed full metabolic regression of the primary tumor and the mediastinal lymph nodes. There was no evidence of new metastasis. Conclusion. Primary SRCC of the lung is a very rare disease with poor prognosis. There are not many cases in literature and no standardized chemotherapy protocols. Cisplatin and docetaxel may be a good treatment option.
- Published
- 2014
- Full Text
- View/download PDF
26. Proteus syndrome: report of intra-abdominal lipomatosis.
- Author
-
Erginel B, Akin M, Yildiz A, Karadag C, Sever N, Tanik C, Erturk M, and Dokucu AI
- Abstract
Proteus syndrome (PS) is an extremely rare sporadic disorder that manifests as an asymmetric, disproportionate overgrowth of any connective tissues, such as bone, fat, or epidermal nevi, in a mosaic or patchy pattern. This hamartoneoplastic syndrome was first described by Cohen and Hayden. Its prevalence is approximately 1 per 1,000,000 live births, and intra-abdominal expansion has been reported in no more than 20 cases in the literature. The phenotypes of the patients differ because of the variation in the pattern of the overgrowths, making diagnosis difficult. Extremely large subcutaneous lipomas and internal lipomas, which occur rarely, are one of the presentation phenotypes. Here, we present the second patient in the literature with PS involving the epiploon.
- Published
- 2013
- Full Text
- View/download PDF
27. Immunohistochemical expression of ErbB2 in adamantinomatous craniopharyngiomas: a possible target for immunotherapy.
- Author
-
Zuhur SS, Tanik C, Erol RS, Musluman AM, Kabukcuoglu F, and Altuntas Y
- Subjects
- Adolescent, Adult, Cell Differentiation physiology, Cell Survival physiology, Child, Child, Preschool, Craniopharyngioma therapy, Female, Humans, Immunohistochemistry, Immunotherapy methods, Male, Middle Aged, Pituitary Neoplasms therapy, Young Adult, beta Catenin metabolism, Craniopharyngioma metabolism, Craniopharyngioma pathology, Pituitary Neoplasms metabolism, Pituitary Neoplasms pathology, Receptor, ErbB-2 metabolism
- Abstract
Aim: To determine the immunohistochemical expression of ErbB2 in adamantinomatous craniopharyngiomas (ACP) and to assess its relationship with nuclear expression of β-catenin in surgically resected human ACP tissue sections and to estimate whether these tumors could be candidates for anti-ErbB2 therapy., Material and Methods: The ErbB2 and β-catenin immunostaining was performed on paraffin embedded tissue sections of 20 ACP using avidin-biotin-peroxidase complex method. ErbB2 immunoreactivity was interpreted according to the American Society of Clinical Oncology/ College of American Pathologists criterions for breast carcinoma., Results: Foci of nuclear reactivity for β-catenin was observed in all ACP tissue specimens mainly concentrated in whorl like arrays of the epithelial cells. Two (10%) of the cases were score 3+ for ErbB2 as demonstrated by strong complete membrane staining. However, the localization of 3+ ErbB2 cells was different from those with nuclear β-catenin immunoreactivity., Conclusion: Our preliminary data demonstrate score 3+ staining for ErbB2 in 10% of ACP and different localization of 3+ ErbB2 cells and cells with nuclear β-catenin immunoreactivity. However, because of the small number of cases, further studies with larger samples should be conducted to verify and validate our preliminary data and to determine the effect of ErbB2 protein in ACP cell growth, survival and differentiation.
- Published
- 2013
- Full Text
- View/download PDF
28. MGMT immunoexpression in growth hormone-secreting pituitary adenomas and its correlation with Ki-67 labeling index and cytokeratin distribution pattern.
- Author
-
Zuhur SS, Tanik C, Karaman Ö, Velet S, Çil E, Öztürk FY, Özkayalar H, Müslüman AM, and Altuntaş Y
- Subjects
- Adenoma drug therapy, Adenoma pathology, Adult, Aged, Antineoplastic Agents, Alkylating therapeutic use, Cell Nucleus metabolism, Cell Nucleus pathology, Dacarbazine analogs & derivatives, Dacarbazine therapeutic use, Drug Resistance, Neoplasm, Female, Humans, Immunohistochemistry, Male, Middle Aged, Pituitary Neoplasms drug therapy, Pituitary Neoplasms pathology, Protein Transport, Temozolomide, Adenoma metabolism, DNA Modification Methylases metabolism, DNA Repair Enzymes metabolism, Human Growth Hormone metabolism, Keratins metabolism, Ki-67 Antigen metabolism, Neoplasm Proteins metabolism, Pituitary Neoplasms metabolism, Tumor Suppressor Proteins metabolism
- Abstract
Recent publications suggest the utility of temozolomide (TMZ) in the management of aggressive pituitary adenomas and carcinomas, resistant to conventional treatments. The response to TMZ is inversely correlated with tumoral expression of O-6 methylguanine DNA methyl transferase (MGMT). Therefore, we aimed to assess MGMT immunoexpression in pure GH-secreting pituitary adenomas, in an effort to predict the likelihood of response to TMZ, and to correlate MGMT immunoexpression with Ki-67 LI and cytokeratin (CK) distribution pattern. Our material consisted of 36 GH-secreting pituitary adenomas (21 female,15 male, mean age 42.5±10.5), operated at our center between 2003 and 2010. Immunostaining for MGMT, Ki-67, and CK was performed using avidin-biotin-peroxidase complex method. Immunoreactivity for MGMT and Ki-67 was evaluated microscopically and recorded as percentages of positive nuclear immunostaining. CK distribution pattern was also evaluated microscopically and assoreted into dot-like and nondot-like pattern subtypes. MGMT immunoexpression scored as 0=none, 1=<10%, 2=<25%, 3=<50%, and 4=>50%. Staining for MGMT was <10% (score 1) in 30 (83.3%), 10-25% (score 2) in 3 (8.3%), 25-50% (score 3) in 2 (5.6%) and >50% (score 4) in 1 (2.8%) of the tumors, respectively. There was no correlation between Ki-67 LI and CK distribution pattern with MGMT immunoreactivity (P>0.05). Data from the current study suggest a large proportion of GH-secreting adenomas, including those with dot-like CK distribution pattern and high Ki-67 LI, demonstrate negative/low MGMT immunoreactivity and could be treated with TMZ, if conventional treatment fails.
- Published
- 2011
- Full Text
- View/download PDF
29. Meningioma causing hyperostosis of the cranial convexity in a child.
- Author
-
Yilmaz A, Müslüman AM, Cavuşoğlu H, Colak I, Tanik C, and Aydin Y
- Subjects
- Child, Female, Humans, Hyperostosis pathology, Hyperostosis surgery, Meningeal Neoplasms pathology, Meningeal Neoplasms surgery, Meningioma pathology, Meningioma surgery, Hyperostosis etiology, Meningeal Neoplasms complications, Meningioma complications, Skull pathology
- Abstract
We present an 8-year-old girl with meningioma-associated hyperostosis. The patient was referred to our clinic due to headache and a frontoparietal midline swelling that was more prominent on the right side of the cranium. A cranial MRI revealed a frontoparietal parasagittal meningioma, accompanied by a diffuse hyperostosis, that appeared to extend extracranially. She underwent a right frontoparietal craniotomy and the tumor, together with the affected bone, was successfully removed. The histological examination confirmed meningioma (World Health Organization 2007 Grade 1) in the intracranial and extracranial lesions. Meningioma causing hyperostosis in a child is rare. The precise mechanism of hyperostosis associated with meningioma remains unclear; however, the most widely accepted theory is that the tumor invades the bone.
- Published
- 2010
- Full Text
- View/download PDF
30. Persistent hyperinsulinemic hypoglycemia with left ventricular hypertrophy and dysrhythmia: a case report.
- Author
-
Bulbul A, Bolat F, Comert S, Demirin H, Tanik C, Bulbul L, Nuhoglu A, and Dokucu AI
- Subjects
- Arrhythmias, Cardiac complications, Arrhythmias, Cardiac physiopathology, C-Peptide blood, Congenital Hyperinsulinism complications, Congenital Hyperinsulinism physiopathology, Fatal Outcome, Humans, Hypertrophy, Left Ventricular complications, Hypertrophy, Left Ventricular physiopathology, Infant, Newborn, Insulin blood, Male, Pancreatectomy, Arrhythmias, Cardiac diagnosis, Congenital Hyperinsulinism diagnosis, Hypertrophy, Left Ventricular diagnosis, Pancreas pathology
- Abstract
Persistent hyperinsulinemic hypoglycemia in neonatal period is characterized by insulin hypersecretion. The major feature is severe hypoglycemia, generally unresponsive to routine medical treatment. Subtotal or total pancreatectomy is performed in unresponsive cases. In this case report, we present a newborn with persistent hypoglycemia unresponsive to medical treatment with dysrhythmic left ventricular hypertrophy. The insulin/C-peptide ratio was 58 as a confirmation of diagnosis. Since hypoglycemia persisted after the initial medical treatment, a subtotal pancreatectomy was performed followed by near-total pancreatectomy. A histologic examination revealed diffuse insulin islets. At the 70th post-natal day, death occurred due to heart failure and ventricular dysrhythmia. To our knowledge, severe dysrhythmia and left ventricular hypertrophy in persistent hyperinsulinemic hypoglycemia (PPH) is identified in the patient.
- Published
- 2010
- Full Text
- View/download PDF
31. The impact of automatic retractors on the esophagus during anterior cervical surgery: an experimental in vivo study in a sheep model.
- Author
-
Cavuşoğlu H, Tuncer C, Tanik C, Mutlu Z, Zengin E, Karabağli M, and Aydin Y
- Subjects
- Animals, Disease Models, Animal, Diskectomy methods, Edema diagnostic imaging, Edema etiology, Edema pathology, Esophagitis diagnostic imaging, Esophagitis etiology, Esophagitis pathology, Esophagus diagnostic imaging, Esophagus pathology, Female, Postoperative Complications diagnostic imaging, Postoperative Complications pathology, Radiography, Sheep, Cervical Vertebrae surgery, Diskectomy instrumentation, Esophagus injuries, Postoperative Complications etiology, Surgical Instruments adverse effects
- Abstract
Object: Postoperative dysphagia is a well-recognized complication of the anterior surgical approach to the cervical spine. However, its incidence and etiology remain unknown. The aim of this study was to investigate the impact of automatic retractor use on the esophagus and to describe the related pathological changes that might occur during cervical spine surgery., Methods: A single-level cervical discectomy was performed via an anterior approach in 16 skeletally mature female sheep. Continuous retraction was applied with an automatic retractor system during surgery. The sheep model was chosen because of anatomical similarities to the human esophagus. The esophageal tract in every animal was examined using contrast radiographic examination. Eight animals were killed 3 days after the operation (Group 1). The remaining sheep were killed 4 weeks after the operation (Group 2). The esophagi were removed for histopathological study, which was performed using H & E and Masson trichrome staining. The changes in esophageal innervation were examined with nicotinamide adenine dinucleotide diphosphate-diaphorase histochemical staining., Results: Only 1 animal (a Group 1 sheep) demonstrated any postoperative radiographic abnormality. In Group 1 sheep, histopathological study of the esophagi at the treated level revealed edema between the muscular fibers in the outer longitudinal and inner circular layers of the muscularis propria. At some points, obvious signs of vascular congestion, vascular damage, and inflammation were observed. In the Group 2 animals, there was mild-to-moderate fibrosis extending from the outer surface of the esophagus to the longitudinal layers of the muscularis propria in the area to which retraction had been applied. Enzyme-histochemical staining revealed the presence of normal myenteric plexus and ganglion cells, and nitrergic innervation in all parts of the esophagus wall., Conclusions: The results of this study demonstrate that direct pressure induced by the medial retractor blade on the esophagus wall leads to local injury. Postoperative dysphagia in human patients who have undergone anterior cervical spine surgery could be a clinical manifestation of this phenomenon.
- Published
- 2009
- Full Text
- View/download PDF
32. Breast carcinoma metastasis in recurrent myxoid liposarcoma.
- Author
-
Kabukcuoglu F, Kabukcuoglu Y, Tanik C, Sakiz D, and Karsidag S
- Subjects
- Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms metabolism, Breast Neoplasms therapy, Carcinoma, Ductal, Breast metabolism, Carcinoma, Ductal, Breast therapy, Combined Modality Therapy, Fatal Outcome, Female, Humans, Immunohistochemistry, Liposarcoma, Myxoid metabolism, Mastectomy, Middle Aged, Neoplasm Recurrence, Local metabolism, Neoplasm Recurrence, Local pathology, Neoplasm Staging, Neoplasms, Second Primary metabolism, Radiotherapy, Soft Tissue Neoplasms metabolism, Breast Neoplasms pathology, Carcinoma, Ductal, Breast pathology, Liposarcoma, Myxoid pathology, Neoplasms, Second Primary pathology, Soft Tissue Neoplasms pathology
- Abstract
Tumor to tumor metastasis is a rare, but well recognized entity, most commonly involving a carcinoma metastasis to a benign or low grade mesenchymal tumor. A case of breast carcinoma metastasis in a recurrent myxoid liposarcoma is presented in this study. A 52-year-old female patient with a history of breast carcinoma (70% invasive lobular carcinoma and 30% invasive ductal carcinoma) presented with a mass in the right lumbar region. The excised mass was diagnosed as myxoid liposarcoma. The tumor recurred twice and was reexcised. Microscopic examination of the second recurrence revealed multiple foci of breast carcinoma metastases in myxoid liposarcoma. Immunohistochemical study showed staining for CK19, GCDFP-15, estrogen and progesterone in metastases. Both breast carcinoma metastasis and myxoid liposarcoma were immunoreactive for E-cadherin and beta-catenin. To our knowledge, this is the first reported case of breast carcinoma metastasis in myxoid liposarcoma, and the first occurrence of metastasis in a liposarcoma.
- Published
- 2009
- Full Text
- View/download PDF
33. Pigmented villonodular synovitis of a lumbar intervertebral facet joint.
- Author
-
Müslüman AM, Cavuşoğlu H, Yilmaz A, Dalkiliç T, Tanik C, and Aydin Y
- Subjects
- Decompression, Surgical, Female, Humans, Lumbar Vertebrae surgery, Magnetic Resonance Imaging, Middle Aged, Synovitis, Pigmented Villonodular surgery, Tomography, X-Ray Computed, Zygapophyseal Joint surgery, Lumbar Vertebrae pathology, Sciatica etiology, Synovitis, Pigmented Villonodular pathology, Zygapophyseal Joint pathology
- Abstract
Background Context: Pigmented villonodular synovitis (PVNS) is a slowly progressive lesion of uncertain etiology that involves the synovial membrane of joints or tendon sheaths. Only rarely does PVNS affect the axial skeleton, where it arises from the vertebral articular facet joint. Its treatment and prognosis remains limited., Purpose: To describe our management in a patient with PVNS and to review previously published cases., Study Design: Case report., Methods: This is a case report of a 59-year-old woman who presented left sciatica. Computed tomography (CT) imaging revealed a mixed sclerotic and lucent lesion affecting the left L4-L5 facet joint. Magnetic resonance imaging (MRI) demonstrated a diffusely infiltrative process that originated from the left inferior articular process of L4 vertebra with extension into the spinal canal. A total synovectomy with left L4 hemilaminectomy was performed. Left L5 root was decompressed with total microscopic tumor removal. Decompression of spinal canal and absence of the tumor was shown by MRI and CT scan after the operation., Results: Complete resolution of the patient's complaints was achieved. Histopathological analysis was consistent with a diagnosis of PVNS., Conclusions: The principle of surgical management of spinal lesions causing neurologic deficit is early surgical decompression. It is also important to totally remove the synovium, the origin of PVNS, to prevent the recurrence.
- Published
- 2009
- Full Text
- View/download PDF
34. Spinal cord compression caused by a brown tumor at the cervicothoracic junction.
- Author
-
Kaya RA, Cavuşoğlu H, Tanik C, Kahyaoğlu O, Dilbaz S, Tuncer C, and Aydin Y
- Subjects
- Aged, Bone Transplantation, Decompression, Surgical, Humans, Hyperparathyroidism, Secondary pathology, Magnetic Resonance Imaging, Male, Renal Insufficiency complications, Spinal Cord Compression pathology, Spinal Cord Compression surgery, Spinal Fusion, Spinal Neoplasms pathology, Spinal Neoplasms surgery, Tomography, X-Ray Computed, Hyperparathyroidism, Secondary complications, Spinal Cord Compression etiology, Spinal Neoplasms complications
- Abstract
Background Context: Brown tumors are classic benign skeletal manifestations of hyperparathyroidism, but the spine involvement is very rare. Spinal reconstruction in these patients is controversial because of the severe osteoporosis and impaired bone healing. Of the reported 12 cases of spinal brown tumors in the literature, only in 5 were reconstructions with bone graft used., Purpose: To describe our management in a patient with brown tumor and also to review the previous published cases., Study Design: Case report., Methods: A case of a brown tumor in the T1 vertebra of a 72-year-old male patient is described. He had a previous diagnosis of secondary hyperthyroidism caused by renal failure. First, posterior transpedicular open biopsy was performed for the diagnosis and also for the decompression of the root causing brachialgia. After the diagnosis of a brown tumor, the patient was reoperated through anterior approach for total tumor removal and reconstruction of the spine. An autolog 3-cortical iliac crest strut graft was used for fusion, and medical treatment of hyperparathyroidism was given immediately after the operation. Decompression of spinal canal and fusion of bone graft was shown by a computed tomography scan 1 year after the operation., Results: Complete resolution of the complaints of the patient and fusion of the graft were achieved., Conclusion: The determination of a spinal tumor in a patient with renal failure and hyperparathyroidism should bring to mind the probability of a brown tumor. Although it is of a benign nature, it can cause severe neurologic deficit because of spinal compression. The recommended treatment modality is surgical resection of the tumor, spinal reconstruction, and aggressive treatment of hyperparathyroidism both with parathyroidectomy and medically.
- Published
- 2007
- Full Text
- View/download PDF
35. Two children with invasive gastrointestinal aspergillosis.
- Author
-
Kayiran P, Urganci N, Cetinkaya F, and Tanik C
- Subjects
- Amphotericin B therapeutic use, Aspergillosis immunology, Aspergillosis microbiology, Gastrointestinal Diseases immunology, Gastrointestinal Diseases microbiology, Gastrointestinal Tract immunology, Humans, Infant, Male, Risk Factors, Agammaglobulinemia complications, Aspergillosis diagnosis, Gastrointestinal Diseases diagnosis, Gastrointestinal Tract microbiology, Immunocompromised Host
- Abstract
We report two immunocompromised infants aged six and four months with invasive gastrointestinal aspergillosis. Both patients presented with weight loss and diarrhea. The underlying disorders were combined immunodeficiency and transient hypogammaglobulinemia of infancy. The diagnosis of gastrointestinal aspergillosis was established by gastrointestinal endoscopy and histopathological examination of the tissue specimens. Both children responded well to Amphotericin B.
- Published
- 2007
36. The effects of magnesium particles in posterolateral spinal fusion: an experimental in vivo study in a sheep model.
- Author
-
Kaya RA, Cavuşoğlu H, Tanik C, Kaya AA, Duygulu O, Mutlu Z, Zengin E, and Aydin Y
- Subjects
- Animals, Bone Screws, Bone Transplantation, Female, Lumbar Vertebrae diagnostic imaging, Lumbar Vertebrae pathology, Microscopy, Electron, Scanning, Particle Size, Sheep, Tomography, X-Ray Computed, Transplantation, Autologous, X-Ray Diffraction, Lumbar Vertebrae surgery, Magnesium, Prostheses and Implants, Spinal Fusion methods
- Abstract
Object: Magnesium has recently become a material of interest as a biocompatible and biodegradable implant metal. Authors of several reports have noted the potential bone-cell activating or bone-healing effect of high Mg ion concentrations. The classic method for achieving intertransverse process fusion involves using an autologous iliac crest bone graft. Several studies have been performed to investigate enhancement of this type of autograft fusion. To the authors' knowledge, no research has been conducted in which the efficacy of pure Mg particles in posterolateral spinal fusion has been investigated. The objective of this study was to determine whether Mg particles enhance the effectiveness of intertransverse process lumbar fusion in a sheep model., Methods: Sixteen skeletally mature female sheep were subjected to intertransverse process spinal fusions with pedicle screw fixation at L2-3 and L5-6. Each animal was given a 5-cm3 bone autograft at one fusion level, and a combined 5-cm3 bone autograft with the addition of 1 cm3 Mg at the other level. Six months after surgery, bone formation was evaluated by gross inspection and palpation, and by radiological, histological, scanning electron microscopic, and x-ray diffraction analyses. Radiological results were graded from 0 to 4 according to the status of the bridging bone, which was determined by evaluating both x-ray films and computed tomography scans. The quality of the spinal fusion was assigned a histological score of 0 to 7, in which a score of 0 represented an empty cleft and a score of 7 represented complete bridging of bone between the transverse processes. The trabecular bone formation at each fusion level and the Ca hydroxyapatite crystalline structure in core biopsy specimens were evaluated using scanning electron microscopy and x-ray diffraction analyses, respectively. The rate of rigid bone fusion, according to both palpation and radiological assessment, in the combined Mg and autologous bone treatment group was higher (81.25%) than in the autograft bone treatment group (62.5%), but this difference was not statistically significant. The quality of bone fusion, according to the histological grading system and scanning electron microscopy inspection, was higher in the bone fusion segments of the Mg and autologous graft combined group than in the group with autograft-only arthrodesis, and this difference was statistically significant. The x-ray diffraction analyses further confirmed the effect of Mg in promoting the formation of the crystalline portion of the bone (hydroxyapatite)., Conclusions: Based on the results of this study, adding Mg particles to autologous corticocancellous bone in a posterolateral intertransverse process fusion enhances the quality of bone formation. However, radiological findings did not reveal a statistically significant effect of Mg on the rate of solid bone fusion formation between the two transverse processes.
- Published
- 2007
- Full Text
- View/download PDF
37. Recurrent mucinous cystadenoma in a 20-year-old woman: was hysterectomy inevitable?
- Author
-
Baksu B, Akyol A, Davas I, Yazgan A, Ozgul J, and Tanik C
- Subjects
- Adult, Female, Humans, Cystadenoma, Mucinous surgery, Hysterectomy, Neoplasm Recurrence, Local surgery, Ovarian Neoplasms surgery, Ovariectomy
- Abstract
A recurrence of ovarian mucinous cysts is very rare. Over a period of 21 months, a 20-year-old patient had three laparotomies resulting initially in the removal of one ovary with a mucinous cystadenoma and two cystectomies for the same pathology, but ultimately leading to hysterectomy and salphingo-oopherectomy. Because mucinous tumors are usually benign and most of the time multilocular, management of young patients is challenging, especially in the case of recurrence. Follow-up of these patients is very important and transvaginal ultrasound seems to be currently the most effective diagnostic tool for the follow-up of young patients treated with cystectomy for benign mucinous cystadenomas.
- Published
- 2006
- Full Text
- View/download PDF
38. Sialoblastoma: a congenital epithelial tumor of the salivary gland.
- Author
-
Tatlidede S, Karsidag S, Ugurlu K, Sadikoglu B, Tanik C, and Bas L
- Subjects
- Carcinoma surgery, Child, Preschool, Fatal Outcome, Female, Humans, Parotid Neoplasms surgery, Reoperation, Salivary Gland Neoplasms diagnosis, Salivary Gland Neoplasms surgery, Carcinoma diagnosis, Neoplasm Recurrence, Local diagnosis, Neoplasm Recurrence, Local surgery, Parotid Neoplasms diagnosis
- Abstract
Sialoblastoma is a rare congenital epithelial tumor of the salivary gland that is diagnosed at birth or shortly thereafter with significant variability in histologic range and clinical course; hence, for an individual case, it may be difficult to predict the most appropriate therapy [Cancer 1972;30:459-69; Pediatr Pathol 1988;8:447-52; Br J Plast Surg 2000;53(8):697-699]. We report the case of a 4-year-old girl who had a widely spreading sialoblastoma of the left cheek. We were obligated to widely resect the tumor including the trunk of the facial nerve, superior part of the left maxilla, and the zygoma. Although the patient was operated 3 times in 4 years, invasion of the tumor could not be stopped. The patient died because of respiratory insufficiency and deterioration of her general health.
- Published
- 2006
- Full Text
- View/download PDF
39. Tentorial vascularization in solid hemangioblastoma--case report.
- Author
-
Ozveren MF, Topsakal C, Erol FS, Kaplan M, Uchida K, and Tanik C
- Subjects
- Adult, Brain surgery, Cerebellar Neoplasms blood supply, Cerebellar Neoplasms diagnosis, Cerebellar Neoplasms pathology, Diagnosis, Differential, Female, Hemangioblastoma blood supply, Hemangioblastoma diagnosis, Hemangioblastoma pathology, Humans, Magnetic Resonance Imaging, Postoperative Hemorrhage etiology, Tomography, X-Ray Computed, Treatment Outcome, von Hippel-Lindau Disease diagnosis, Brain pathology, Cerebellar Neoplasms surgery, Craniotomy, Hemangioblastoma surgery, Postoperative Hemorrhage surgery
- Abstract
A 40-year-old female was admitted to the hospital with complaints of headache worsening gradually over a 1-month duration. Her past history included surgery to treat a left cerebellar cystic lesion 3 years before, and an untreated small solid right supracerebellar lesion of 1 cm diameter. On admission, magnetic resonance imaging showed that the right cerebellar lesion had grown to approximately 4 cm diameter abutting the tentorium and causing obstructive hydrocephalus. She also had two more small lesions, a right supratentorial solid lesion with cystic component near the splenium and an intramedullary cystic lesion at the C-2 level. Right suboccipital craniectomy was done. The vascular attachments between the superior aspect of the tumor and the tentorium were coagulated and the tumor was totally removed. C1-2 laminectomy was also performed to drain the intramedullary cyst. The patient deteriorated and lost consciousness with respiratory arrest 6 hours postoperatively and was reoperated for intracerebellar hematoma due to oozing from the tentorial vessels. Histological investigation revealed hemangioblastoma. Dural tentorial vascular attachments in solid hemangioblastomas located subjacent to the tentorium may cause early postoperative complications of hematoma at the site of vascular attachment following the resection. Computed tomography study in the early postoperative period is helpful to identify this problem.
- Published
- 2001
- Full Text
- View/download PDF
40. Cerebral metastasis of a uterine leiomyosarcoma--case report.
- Author
-
Ziyal IM, Musluman M, Bejjani GK, Tanik C, Türkmen CS, and Aydin Y
- Subjects
- Adult, Brain Neoplasms diagnostic imaging, Brain Neoplasms pathology, Female, Humans, Leiomyosarcoma diagnostic imaging, Leiomyosarcoma pathology, Tomography, X-Ray Computed, Brain Neoplasms secondary, Leiomyosarcoma secondary, Uterine Neoplasms pathology
- Abstract
A 38-year-old female presented with sudden neurological deterioration 6 years after an operation and chemotherapy for uterine leiomyosarcoma. An extremely rare metastasis of the uterine leiomyosarcoma to the brain was identified and totally resected. Whole brain irradiation (50 Gy) was given. A recurrence of the metastasis was resected 10 weeks later. She ultimately died of a second recurrence. Aggressive surgical management of cerebral metastasis of uterine leiomyosarcoma may achieve an improved outcome.
- Published
- 1999
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.