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The southwestern Tianshan Mountains is an important producing area of the Meso-Cenozoic stratabound glutenite-type Cu-Pb-Zn deposits in Xinjiang. Sareke copper mine, Wulagen lead-zinc mine, Huayuan copper mine and Jiashi copper mine are the representative deposits, which all occur in the red bed basin on the edge of the uplift denudation area and are strictly controlled by strata. The lower part of the ore-bearing basin is composed of coal-bearing hydrocarbon-generating rocks, the middle part is well-permeable glutenites as the Cu-Pb-Zn reservoir, and the overlying layer is a sealed cap formed by gypsum rocks and mudstones, showing the ore-forming characteristics of co-enrichment of Cu-Pb-Zn-Uranium-coal-natural gas in the same basin. In this paper, we summarized the sedimentary-tectonic evolution of these ore-bearing basins and the characteristics of ore-bearing layers, and analyzed the ore-controlling conditions and metallogenic characteristics of typical copper, lead and zinc deposits. Combining with comparative analysis, we summarized the regional metallogenic regularity of the Meso-Cenozoic glutenite-type Cu-Pb-Zn deposit, and hold the view that organic matter is closely related to Cu-Pb-Zn mineralization. Moreover, it is inferred that Cu-Pb-Zn-lean ore bodies were formed over the original source layer in the uplift caused by the superimposition of oilfield brine; Cu-Pb-Zn-rich ore bodies were formed by the superimposition of deep-source ore-forming fluids from the Himalayan fault structure. The metallogenic model of the middle Cenozoic stratabound glutenite-type Cu-Pb-Zn deposits in the southwestern Tianshan Mountains provides a basis for the exploration of the known mines in their deep and edge, and also provides guidance for the regional prospecting work.

[Introduction] The paper aims to reduce the intermittent, random, uncontrollable effects of DERs capacity represented by wind and solar energy, and to participate in the competition in the power market, a community-based energy Internet model is proposed. [Method] Considering a community-based energy Internet model consisting of a virtual power plant (VPP) cluster consisting of a wind farm, a photovoltaic power station, and a load, interconnecting a single VPP, and based on the balance of supply and demand within a single VPP, the surplus power game sharing through VPP clusters, and finally trading with the electricity market to achieve reverse sales. [Results] The results we obtained demonstrate that the goal of maximizing the benefits of community-based energy Internet, and adding demand response (DR) to achieve the purpose of saving electricity for users. [Conclusion] This work through the community energy Internet demonstration project, the VPP operation strategy model is proposed, and the feasibility of verifying the power generation strategy in different scenarios is established through the established benefits, which indicates the direction for the construction and transaction of the community energy Internet.

Osteosarcoma is a malignant tumor abundant in vascular tissue, and its rich blood supply may have a significant impact on its metabolic characteristics. PDGFR[beta] is a membrane receptor highly expressed in osteosarcoma cells and vascular wall cells, and its effect on osteosarcoma metabolism needs to be further studied. In this study, we discussed the effect and mechanism of action of PDGFR[beta] on glucose metabolism in human osteosarcoma (HOS) cells. GSEA, Pearson's correlation test, and PPI correlation analysis indicated positive regulation of PDGFR[beta] on aerobic glycolysis in osteosarcoma. The results of qPCR and western blot further confirmed the prediction of bioinformatics. Glucose metabolism experiments proved that PDGF/PDGFR[beta] could effectively promote aerobic glycolysis in osteosarcoma cells. In addition, the mitochondrial membrane potential ([DELTA][PSI]m) experiment proved that the metabolic change triggered by PDGFR[beta] was not caused by mitochondrial damage. The PI3K pathway inhibitor LY294002, MEK pathway inhibitor U0126, or Warburg effect inhibitor DCA was used to perform western blot and glucose metabolism experiments, and the results showed that PDGFBB/PDGFR[beta] mainly activated the PI3K/AKT/mTOR/c-Myc pathway to promote aerobic glycolysis in osteosarcoma HOS cells. The newly elucidated role of PDGFR[beta] provides a novel metabolic therapeutic target for osteosarcoma. Key words: PDGFR[beta], metabolic reprogramming, aerobic glycolysis, osteosarcoma, c-Myc. L'osteosarcome est une tumeur maligne riche en tissu vasculaire, et son approvisionnement eleve en sang peut avoir un impact significatif sur ses caracteristiques metaboliques. Le PDGFR[beta] est un recepteur membranaire fortement exprime dans les cellules d'osteosarcome et les cellules de la paroi vasculaire, et son effet sur le metabolisme de l'osteosarcome doit etre etudie plus en detail. Dans cette etude, les auteurs ont discute de l'effet et du mecanisme du PDGFR[beta] sur le metabolisme du glucose des cellules d'osteosarcome HOS. Tout d'abord, l'analyse d'enrichissement genique GSEA, le test de correlation de Pearson et l'analyse de correlation des interactions proteine-proteine ont indique une regulation positive du PDGFR[beta] sur la glycolyse aerobie dans l'osteosarcome. Les resultats de la qPCR et du transfert de Western ont egalement confirme la prediction de la bio-informatique. Les experiences sur le metabolisme du glucose ont prouve que le PDGF/PDGFR[beta] pouvait efficacement promouvoir la glycolyse aerobie dans les cellules d'osteosarcome. En outre, l'experience realisee sur le potentiel de la mem-brane mitochondriale a demontre que le changement metabolique declenche par le PDGFR[beta] n'etait pas provoque par des dom-mages mitochondriaux. Le LY294002, un inhibiteur de la voie PI3K, le U0126, un inhibiteur de la voie MEK, ou le DCA, un inhibiteur de l'effet Warburg, ont ete utilises pour realiser des experiences en transfert de Western et sur le metabolisme du glucose, et les resultats ont montre que le PDGFBB/PDGFR[beta] activait principalement la voie PI3K/AKT/mTOR/c-Myc pour promouvoir la glycolyse aerobie dans les cellules d'osteosarcome HOS. Le role nouvellement elucide du PDGFR[beta] fournit une nouvelle cible therapeutique metabolique pour l'osteosarcome. [Traduit par la Redaction] Mots-cles: PDGFR[beta], reprogrammation metabolique, glycolyse aerobie, osteosarcome, c-Myc., 1. Introduction Osteosarcoma is a malignant bone tumor with abundant blood vessels, and the instability of its neovascularization may lead to a change in the oxygenation state of the tumor [...]

Solids in nature can be generally classified into crystalline and non-crystalline states.sup.1-7, depending on whether long-range lattice periodicity is present in the material. The differentiation of the two states, however, could face fundamental challenges if the degree of long-range order in crystals is significantly reduced. Here we report a paracrystalline state of diamond that is distinct from either crystalline or amorphous diamond.sup.8-10. The paracrystalline diamond reported in this work, consisting of sub-nanometre-sized paracrystallites that possess a well-defined crystalline medium-range order up to a few atomic shells.sup.4,5,11-13, was synthesized in high-pressure high-temperature conditions (for example, 30 GPa and 1,600 K) employing face-centred cubic C.sub.60 as a precursor. The structural characteristics of the paracrystalline diamond were identified through a combination of X-ray diffraction, high-resolution transmission microscopy and advanced molecular dynamics simulation. The formation of paracrystalline diamond is a result of densely distributed nucleation sites developed in compressed C.sub.60 as well as pronounced second-nearest-neighbour short-range order in amorphous diamond due to strong sp.sup.3 bonding. The discovery of paracrystalline diamond adds an unusual diamond form to the enriched carbon family.sup.14-16, which exhibits distinguishing physical properties and can be furthered exploited to develop new materials. Furthermore, this work reveals the missing link in the length scale between amorphous and crystalline states across the structural landscape, having profound implications for recognizing complex structures arising from amorphous materials. A study describes the synthesis, structural characterization and formation mechanism of a paracrystalline state of diamond, adding an unusual form of diamond to the family of carbon-based materials., Author(s): Hu Tang [sup.1] , Xiaohong Yuan [sup.1] , Yong Cheng [sup.2] , Hongzhan Fei [sup.3] , Fuyang Liu [sup.1] , Tao Liang [sup.1] , Zhidan Zeng [sup.1] , Takayuki [...]

The ATP-binding cassette (ABC) transporter is a gene superfamily in plants. ATP-binding cassette subfamily C (ABCC) protein is a multidrug resistance-associated (MRP) transporter. They play various roles in plant growth, development, and secondary metabolite transport. However, there are few studies on ABCC transporters in tea plants. In this study, genome-wide association study (GWAS) analysis of epigallocatechin gallate (EGCG) content in 108 strains of Kingbird revealed that CsABCCs may be involved in EGCG transport. We identified 25 CsABCC genes at the genomic level of the tea plant, their phylogenetic tree, gene structure, targeted miRNA and other bioinformatics were analyzed. The expression patterns of CsABCCs in eight different tissues and abiotic stress indicate that they have potential roles in regulating the growth, development, and defense of tea plants. The correlation analysis revealed that the expression of the CsABCC11 gene was closely related to the EGCG content in tea buds of 108 strains of the Kingbird, and the subcellular localization experiments in tobacco showed that CsABCC11 protein was localized on the plasma membrane. The virus-induced gene silencing (VIGS) strategy in tea plants further verified that CsABCC11 was involved in EGCG accumulation. Our study laid a foundation for studying the biological function of CsABCC and provided a new candidate molecular marker gene for further EGCG-related variety breeding, which will be of great interest to breeders. Supplementary Material Supplementary Material File [ABSTRACT FROM AUTHOR]

Lithium-ion batteries, as the main energy storage component of electric vehicles (EVs), play a crucial role in ensuring the safe and reliable operation of the battery systems through monitoring their state of health (SOH). However, temperature variations and battery aging have significant impacts on the internal parameters of lithium-ion batteries, and these changes directly correlate with the accuracy of battery SOH estimation. To address these issues, this paper proposes an estimation method for lithium-ion battery SOH that considers the impact of temperature. The method begins with reconstructing a second-order hybrid equivalent circuit model for lithium-ion batteries, through which an adaptive update rate for battery model parameters is designed. On this basis, a nonlinear observer for battery states is introduced by integrating filters to estimate SOH. The proposed method considers the impact of capacity in the design of the parameter adaptive update rate, enabling the capacity to be dynamically adjusted based on the actual state of the batteries. This reduces the cumulative error in the SOC observer and improves the modeling accuracy of battery models. Experimental results demonstrate that the method proposed in this paper exhibits exceptional performance in SOH estimation under different temperature conditions. The mean absolute error for SOH estimation does not exceed 0.5%, and the root mean square error does not exceed 0.2%. This method can significantly improve the estimation accuracy of SOH, providing a more efficient and accurate solution for battery management systems in EVs. [ABSTRACT FROM AUTHOR]