1. ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway.
- Author
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Rodvold JJ, Grimmer M, Ruiz K, Marsters SA, Oikonomidi I, Tan-Aristy E, Pham VC, Sarkar T, Harnoss JM, Shatz-Binder W, Modrusan ZD, Wu TD, Lill JR, Villemure E, Rudolph J, de Sousa E Melo F, and Ashkenazi A
- Subjects
- Humans, Cell Proliferation, Animals, Cell Line, Tumor, Mice, Gene Expression Regulation, Neoplastic, Colorectal Neoplasms pathology, Colorectal Neoplasms genetics, Colorectal Neoplasms metabolism, Wnt Signaling Pathway, Activating Transcription Factor 6 metabolism, Activating Transcription Factor 6 genetics, Neoplastic Stem Cells metabolism, Neoplastic Stem Cells pathology
- Abstract
Significance: ATF6 intervention reduces colorectal cancer cell and organoid viability by interrupting dysregulated Wnt signaling, identifying a novel facilitator and potential therapeutic target in colorectal cancer., (©2024 The Authors; Published by the American Association for Cancer Research.)
- Published
- 2024
- Full Text
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