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ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway.

Authors :
Rodvold JJ
Grimmer M
Ruiz K
Marsters SA
Oikonomidi I
Tan-Aristy E
Pham VC
Sarkar T
Harnoss JM
Shatz-Binder W
Modrusan ZD
Wu TD
Lill JR
Villemure E
Rudolph J
de Sousa E Melo F
Ashkenazi A
Source :
Cancer research communications [Cancer Res Commun] 2024 Oct 01; Vol. 4 (10), pp. 2734-2755.
Publication Year :
2024

Abstract

Significance: ATF6 intervention reduces colorectal cancer cell and organoid viability by interrupting dysregulated Wnt signaling, identifying a novel facilitator and potential therapeutic target in colorectal cancer.<br /> (©2024 The Authors; Published by the American Association for Cancer Research.)

Details

Language :
English
ISSN :
2767-9764
Volume :
4
Issue :
10
Database :
MEDLINE
Journal :
Cancer research communications
Publication Type :
Academic Journal
Accession number :
39324706
Full Text :
https://doi.org/10.1158/2767-9764.CRC-24-0268