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ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway.
- Source :
-
Cancer research communications [Cancer Res Commun] 2024 Oct 01; Vol. 4 (10), pp. 2734-2755. - Publication Year :
- 2024
-
Abstract
- Significance: ATF6 intervention reduces colorectal cancer cell and organoid viability by interrupting dysregulated Wnt signaling, identifying a novel facilitator and potential therapeutic target in colorectal cancer.<br /> (©2024 The Authors; Published by the American Association for Cancer Research.)
- Subjects :
- Humans
Cell Proliferation
Animals
Cell Line, Tumor
Mice
Gene Expression Regulation, Neoplastic
Colorectal Neoplasms pathology
Colorectal Neoplasms genetics
Colorectal Neoplasms metabolism
Wnt Signaling Pathway
Activating Transcription Factor 6 metabolism
Activating Transcription Factor 6 genetics
Neoplastic Stem Cells metabolism
Neoplastic Stem Cells pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2767-9764
- Volume :
- 4
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Cancer research communications
- Publication Type :
- Academic Journal
- Accession number :
- 39324706
- Full Text :
- https://doi.org/10.1158/2767-9764.CRC-24-0268