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Objectives: The purpose of this study was to develop a prototype for controlling the water level of a three-dimensional (3D) water phantom using ultrasound sensors and Arduino technology and evaluate its performance in setting up the 3D water phantom for radiation beam measurements. Materials and Methods: A prototype consisted of an Arduino Nano board and two types of ultrasound sensors (US015 and SR04). The accuracy of both sensors was tested at various distances and the performance was evaluated through statistical analysis. The distance measurement test was performed rigorously at intervals of 2 cm from 5 cm to 21 cm, measuring an average error and a maximum deviation for each sensor. Results: Both sensors demonstrated the measurement accuracy within 2 mm. When using the traditional and prototype-based setup methods, the measured photon and electron beam profiles did not show any significant difference. This result suggests the equivalent setup capability when using these two different 3D water phantom setup methods. Conclusion: The ultrasound sensor-based prototype is demonstrated as a more effective device in maintaining the 3D water phantom setup consistently compared to the traditional method, which is prone to human error, and it will aid in facilitating precise phantom setup during the commissioning and routine quality assurance (QA) of linear accelerators in radiotherapy clinics.

Objectives This study aimed to evaluate the prognostic significance of the revised European LeukemiaNet (ELN)−2022 risk stratification model for 123 elderly acute myeloid leukemia (AML) patients treated with decitabine chemotherapy.Results Based on the ELN-2022 risk stratification, 15 (12.2%), 51 (41.5%), and 57 (46.3%) patients were classified as having favorable, intermediate, and high-risk AML, respectively. In comparison with the ELN-2017 risk stratification, the ELN-2022 risk stratification re-assigned 26 (21.1%) and three (2.4%) patients to the adverse and favorable risk groups, respectively. Survival analysis revealed distinctive overall survival (OS) outcomes among the ELN-2022 risk groups (6-month OS rate: 73.3%, 52.9%, and 47.7% for favorable, intermediate, and adverse risk, respectively; P = 0.101), with a parallel trend observed in the event-free survival (EFS) (6-month EFS rate: 73.3%, 52.9%, and 45.6% for favorable, intermediate, and adverse risk, respectively; P = 0.049). Notably, both OS and EFS in the favorable risk group were significantly superior in comparison to that of the adverse risk group (OS: P = 0.040, EFS: P = 0.030). Although the ELN-2022 C-index (0.559) was greater than the ELN-2017 C-index (0.539), the result was not statistically significant (P = 0.059). Based on the event net reclassification index, we consistently observed significant improvements in the ELN-2022 risk stratification for overall survival (0.21 at 6 months).Conclusion In conclusion, the revised ELN-2022 risk stratification model may have improved the risk classification of elderly AML patients treated with hypomethylating agents compared to the ELN-2017 risk stratification model.

Abstract This study aimed to validate the 2022 European LeukemiaNet (ELN) risk stratification for acute myeloid leukemia (AML). A total of 624 newly diagnosed AML patients from 1998 to 2014 were included in the analysis. Genetic profiling was conducted using targeted deep sequencing of 45 genes based on recurrent driver mutations. In total, 134 (21.5%) patients had their risk classification reassessed according to the 2022 ELN risk stratification. Among those initially classified as having a favorable risk in 2017 (n = 218), 31 and 3 patients were reclassified as having intermediate risk or adverse risk, respectively. Among the three subgroups, the 2022 ELN favorable-risk group showed significantly longer survival outcomes than the other groups. Within the 2017 ELN intermediate-risk group (n = 298), 21 and 46 patients were reclassified as having favorable risk or adverse risk, respectively, and each group showed significant stratifications in survival outcomes. Some patients initially classified as having adverse risk in 2017 were reclassified into the intermediate-risk group (33 of 108 patients), but no prognostic improvements were observed in this group. A multivariable analysis identified the 2022 ELN risk stratification, age, and receiving allogeneic hematopoietic cell transplantation as significant prognostic factors for survival. The 2022 ELN risk stratification enables more precise decisions for proceeding with allogeneic hematopoietic cell transplantation for AML patients.

Purpose: To investigate the prevalence of lower urinary tract symptoms/benign prostatic hyperplasia in a Korean population. Materials and Methods: The Korean Prostate & Voiding Health Association provided free prostate-related community health care and conducted surveys in all regions of Korea from 2001 to 2022 with the cooperation of local government public health centers. A total of 72,068 males older than 50 were surveyed and analyzed. History taking, International Prostate Symptom Score (IPSS), transrectal ultrasonography, prostate-specific antigen (PSA) testing, uroflowmetry, and urine volume testing were performed. Results: The mean prostate volumes in males in their 50s, 60s, 70s, and 80s or above were 24.7 g, 27.7 g, 31 g, and 33.7 g, respectively. The proportion of males with high PSA greater than 3 ng/mL was 3.8% among males in their 50s, 7.7% among males in their 60s, 13.1% among males in their 70s, and 17.9% among males 80 years of age or older. The mean IPSS total scores in males in their 50s, 60s, 70s, and 80s or above were 10.7, 12.7, 14.5, and 16, respectively. Severe symptoms were reported by 27.3% of males, whereas 51.7% reported moderate symptoms. The mean Qmax in males in their 50s, 60s, 70s, and 80s or above were 20 mL/s, 17.4 mL/s, 15.4 mL/s, and 13.8 mL/s, respectively. Conclusions: In this population-based study, mean prostate volume, IPSS, PSA, and Qmax were 30.6±15.1 g, 14.8±8.2, 1.9±4.7 ng/mL, and 15.6±6.5 mL/s, respectively. Aging was significantly associated with increased prostate volume, PSA levels, and IPSS scores, and with decreased Qmax and urine volume.

This paper describes the unique full-scale bollard pull and self-propulsion tests of a large amphibious tracked military vehicle with two waterjet propulsors. To provide a reference for the self-propulsion and cavitation performance, a series of sea trials and bollard pull tests were performed in a military sea bay and in a large test basin, respectively. Good overall agreement between the sea trial and the computation was observed in the speed–power relationship. The cavitation-induced breakdown phenomenon was further explored via numerical simulations. The results indicated that the uncertainties in the numerical results were dominated by the scales of vapor bubbles. The analysis showed that the selection of the vapor bubble scale factors of 1.0 for growth and 0.05 for collapse were in good agreement with the experimental results. Rapid performance breakdown occurred when sufficient suction side-attached cavities were extended into the blade mid-chord and tip-board regions.

Background/Aims We evaluated the role of next-generation sequencing (NGS)-based disease monitoring for elderly patients diagnosed with acute myeloid leukemia (AML) who received decitabine therapy. Methods A total of 123 patients aged > 65 years with AML who received decitabine were eligible. We analyzed the dynamics of variant allele frequency (VAF) in 49 available follow-up samples after the fourth cycle of decitabine. The 58.6% VAF clearance (Δ, [VAF at diagnosis – VAF at follow-up] × 100 / VAF at diagnosis) was the optimal cut-off for predicting overall survival (OS). Results The overall response rate was 34.1% (eight patients with complete remission [CR], six of CR with incomplete hematologic recovery, 22 with partial responses, and six with morphologic leukemia-free status). Responders (n = 42) had significantly better OS compared with non-responders (n = 42) (median, 15.3 months vs. 6.5 months; p < 0.001). Of the 49 patients available for follow-up targeted NGS analysis, 44 had trackable gene mutations. The median OS of patients with ΔVAF ≥ 58.6% (n=24) was significantly better than that of patients with ΔVAF < 58.6% (n = 19) (20.5 months vs. 9.8 months, p = 0.010). Moreover, responders with ΔVAF ≥ 58.6% (n = 20) had a significantly longer median OS compared with responders with VAF < 58.6% (n = 11) (22.5 months vs. 9.8 months, p = 0.004). Conclusions This study suggested that combining ΔVAF ≥ 58.6%, a molecular response, with morphologic and hematologic responses can more accurately predict OS in elderly AML patients after decitabine therapy.

Background/Objective: Spontaneous reporting systems (SRS) such as the Korea Adverse Event Reporting System (KAERS) are limited in their ability to detect adverse drug reaction (ADR) signals due to their limited data on drug use. Conversely, the national health insurance claim (NHIC) data include drug use information for all qualifying residents. This study aimed to compare ADR signal profiles for antidepressants between KAERS and NHIC, evaluating the extent to which detected signals belong to common ADRs and labeling information.Materials and Methods: ADR signal detection in KAERS and NHIC databases, spanning January to December 2017, employed disproportionality analysis. Signal classes were determined based on System Organ Class (SOC) of the Medical Dictionary for Regulatory Activities (MedDRA). Also, Common ADR Coverage (CAC), the proportion of detected signals deemed common ADRs, and labeling information coverage (LIC) represented by mean average precision (mAP) were calculated. Additionally, protopathic bias and relative risk (RR) evaluation were performed to check for signal robustness.Results: Signal detection revealed 51 and 62 signals in KAERS and NHIC databases, respectively. Both systems predominantly captured signals related to nervous system disorders, comprising 33.3% (N = 17) in KAERS and 50.8% (N = 31) in NHIC. Regarding the type of antidepressants, KAERS predominantly reported signals associated with tricyclic antidepressants (TCAs) (N = 21, 41.2%), while NHIC produced most signals linked to selective serotonin reuptake inhibitors (SSRIs) (N = 22, 35.5%). KAERS exhibited higher CAC (68.63% vs. 29.03%) than NHIC. LIC was also higher in KAERS than in NHIC (mAP for EB05: 1.00 vs. 0.983); i.e., NHIC identified 5 signals not documented in drug labeling information, while KAERS found none. Among the unlabeled signals, one (Duloxetine-Myelopathy) was from protopathic bias, and two (duloxetine-myelopathy and tianeptine-osteomalacia) were statistically significant in RR.Conclusion: NHIC exhibited greater capability in detecting ADR signals associated with antidepressant use, encompassing unlabeled ADR signals, compared to KAERS. NHIC also demonstrated greater potential for identifying less common ADRs. Further investigation is needed for signals detected exclusively in NHIC but not covered by labeling information. This study underscores the value of integrating different sources of data, offering substantial regulatory insights and enriching the scope of pharmacovigilance.

Abstract We present a new example of the termination of strike-slip paleoearthquake ruptures in near-surface regions on the Yangsan Fault, Korea, based on multi-scale structural observations. Paleoearthquake ruptures occur mostly along the boundary between the inherited fault core and damage zone (N10–20°E/> 75°SE). The ruptures propagated upward to the shallow subsurface along a σv > σHmin to σHmax > σHmin > σv at depth of a ~ 200 m; and the physical properties of unconsolidated sediment, which have low inter-granular cohesion, resulting in distributed deformation.

Abstract Unlike shot peening, shot blasting is a process that primarily uses shot balls to remove foreign substances from metal surfaces. Shot blasting is classified into air-blowing and impeller-impact types. The latter is widely used in commercial large-scale shot blasting. This study proposes a new control cage with a concave or convex shape to improve coverage and uniformity in the impeller-impact type shot blaster. The effectiveness of the proposed control cage is verified using discrete element methods and experiments. Moreover, the optimal design in terms of mass flow, coverage, and uniformity is confirmed. Additionally, the distribution of marks on the surface is analyzed through experiments and simulations. Further, the shot ball is projected over a wider area on the surface when the new concave and convex model is employed at the control cage. Consequently, we confirm that the control cage with a concave shape forms approximately a 5-% higher coverage than the conventional model and uniform shot marks while using a low mass flow rate.

Brain-computer interfaces (BCIs) can restore impaired cognitive functions in people with neurological disorders such as stroke. Musical ability is a cognitive function that is correlated with non-musical cognitive functions, and restoring it can enhance other cognitive functions. Pitch sense is the most relevant function to musical ability according to previous studies of amusia, and thus decoding pitch information is crucial for BCIs to be able to restore musical ability. This study evaluated the feasibility of decoding pitch imagery information directly from human electroencephalography (EEG). Twenty participants performed a random imagery task with seven musical pitches (C4–B4). We used two approaches to explore EEG features of pitch imagery: multiband spectral power at individual channels (IC) and differences between bilaterally symmetric channels (DC). The selected spectral power features revealed remarkable contrasts between left and right hemispheres, low- (< 13 Hz) and high-frequency ( $>$ 13 Hz) bands, and frontal and parietal areas. We classified two EEG feature sets, IC and DC, into seven pitch classes using five types of classifiers. The best classification performance for seven pitches was obtained using IC and multiclass Support Vector Machine with an average accuracy of 35.68±7.47% (max. 50%) and an information transfer rate (ITR) of 0.37±0.22 bits/sec. When grouping the pitches to vary the number of classes (K = 2–6), the ITR was similar across K and feature sets, suggesting the efficiency of DC. This study demonstrates for the first time the feasibility of decoding imagined musical pitch directly from human EEG.

Abstract In this study, we performed serial monitoring using targeted DNA sequencing to identify genetic alterations in adults with Philadelphia‐positive acute lymphoblastic leukemia (Ph‐ALL). Deep sequencing was performed by targeting the coding regions of 45 genes with recurrent driver mutations and 1129 single nucleotide polymorphism sites. Of the 43 patients that we examined, at least one case of genetic alterations was detected in 38 (88%) of the 43 patients at diagnosis (somatic mutations in 10 patients [23%] and copy number aberrations [CNA] in 36 patients [84%]). The most frequently detected CNA lesions were in IKZF1 (n = 25, 58%) and the most frequently mutated gene was SETD2 (n = 5). At least one genetic abnormality (loss, gain, or persistence) was observed in all the samples obtained at relapse that were available for analysis (n = 15), compared with the samples obtained at diagnosis (disappearance of any previously detected genetic alterations: 11 patients [73%]; new genetic abnormalities: nine patients [60%]; and persistent genetic abnormalities: eight patients [53%]]. The most frequently deleted lesions were in IKZF1 (n = 9, 60%), and the most frequently mutated gene was ABL1 (eight patients, 53%). Our data indicate that leukemic progression may be associated with complex genetic alterations in Ph‐ALL during the course of treatment.

To optimize the peening effect of different shot peening process parameters on metal surfaces, the mapping relationship between different shot peening process parameters and metal surface integrity was obtained. In this paper, ABAQUS software was used to establish a DE-FE (Discrete element-Finite element) random multi-shot analysis model to simulate shot peening, then optimize the shot peening process parameters based on the surface response method(RSM), and finally validate it through experiments and BP(back propagation) neural network model. The result shows that when the shot velocity is 70 m s ^−1 , the impact angle of shot is 61.45°, and the shot diameter is 0.78 mm, the shot peening effect is the best, the surface roughness value is reduced by 101.84%, and the arc height value is increased by 54.66%; the error between the predicted results of BP neural network and the results of numerical analysis is less than 8%. Therefore, the optimized process parameters significantly improve the shot peening effect, but also shows that the BP neural network prediction model can more accurately predict the mapping relationship between the input parameters of shot velocity, shot diameter, and impact angle of shot and the output parameters of roughness value and arc height value.

Abstract Internal tandem duplication of the Feline McDonough Sarcoma (FMS)‐like tyrosine kinase 3 (FLT3‐ITD) is one of the most clinically relevant mutations in acute myeloid leukemia (AML), with a high FLT3‐ITD allelic ratio (AR) (≥0.5) being strongly associated with poor prognosis. FLT3‐ITDs are heterogeneous, varying in size and location, with some patients having multiple FLT3‐ITDs. Bulk cell‐based approaches are limited in their ability to reveal the clonal structure in such cases. Using single‐cell proteogenomic sequencing (ScPGseq), we attempted to identify a relapse‐fated subclone in an AML case with mutations in WT1, NPM1, and FLT3 tyrosine kinase domain and two FLT3‐ITDs (21 bp and 39 bp) (low AR) at presentation, then relapsed only with WT1 and NPM1 mutations and one FLT3‐ITD (high AR). This relapse‐fated subclone at presentation (∼2.1% of sequenced cells) was characterized by the presence of a homozygous 21 bp FLT3‐ITD resulting from copy neutral loss of heterozygosity (CN‐LOH) of chr13q and an aberrant, immature myeloid cell surface signature, contrast to the cell surface phenotype at presentation. In contrast to results from multicolor flow‐cytometry, ScPGseq not only enabled the early detection of rare relapse‐fated subclone showing immature myeloid signature but also highlighted the presence of homozygous 21 bp FLT3‐ITDs in the clone at presentation.

The objective of this paper is to analyze and identify the range of voltage balancing capability of grid-forming inverters serving three-phase unbalanced loads. These inverters are designed to compensate for voltage imbalance by controlling the negative-sequence components of voltage and current. However, the magnitude of the negative-sequence current an inverter can supply is limited by its relatively low rated current. Moreover, it becomes more challenging to estimate the amount of current needed for an unbalanced load when the inverter is interfaced using a delta-wye grounded interconnection transformer. Therefore, we investigate the range of negative-sequence current the inverter can supply and derive formulas to determine the minimum inverter’s capacity required to compensate for voltage imbalance while supplying unbalanced loads connected through a delta-wye grounded transformer. The proposed formulas can be used to estimate the capacity of an inverter in lieu of detailed analyses and electromagnetic transient simulations. The proposed equation is implemented in small and large scale microgrid systems and validated using a detailed model developed in PSCAD/EMTDC.

Donor clonal hematopoiesis may be transferred to the recipient through allogeneic hematopoietic stem cell transplantation (HSCT), but the potential for adverse long-term impact on transplant outcomes remains unknown. A total of 744 samples from 372 recipients who received HSCT and the corresponding donors were included. Bar-coded error-corrected sequencing using a modified molecular inversion probe capture protocol was performed, which targeted 33 genes covering mutations involved in clonal hematopoiesis with indeterminate potential (CHIP) and other acute myeloid leukemia-related mutations. A total of 30 mutations were detected from 25 donors (6.7%): the most frequently mutated gene was TET2 (n=7, 28%), followed by DNMT3A (n=4, 16%), SMC3 (n=3, 12%) and SF3B1 (n=3, 12%). With a median follow-up duration of 13 years among survivors, the presence of CHIP in the donor was not associated with recipient overall survival (P=0.969), relapse incidence (P=0.600) or non-relapse mortality (P=0.570). Donor CHIP did not impair neutrophil (P=0.460) or platelet (P=0.250) engraftment, the rates of acute (P=0.490), or chronic graft-versus-host disease (P=0.220). No significant difference was noted for secondary malignancy following HSCT between the two groups. The present study suggests that the presence of CHIP in allogeneic stem donors does not adversely affect transplant outcomes after HSCT. Accordingly, further study is warranted to reach a clearer conclusion on whether molecular profiling to determine the presence of CHIP mutations is necessary for the pretransplant evaluation of donors prior to stem cell donation.

The positive effect of traffic-responsive signal control can be assured when real-time traffic data is reliable, but data reliability may be an issue that depends on the number of probe vehicles equipped with navigation devices or smartphones. However, there is a high chance of improving reliability with the recent deployment of connected vehicles (CVs) that use the vehicle-to-everything (V2X) communication data. Therefore, this paper proposes a traffic signal control strategy that utilizes V2X communication data obtained from CV operations, which is called the capacity waste reduction (CWR) strategy. In this strategy, vehicle queues on each road lane as an intersection approaches are initially estimated using V2X data. Then, the signal control algorithm determines the duration of the green signal for the currently applied phase based on the estimated vehicle queues. Furthermore, the strategy includes an algorithm for active priority signal control for the vehicles of bus rapid transit systems. The efficiency of the provided control strategy is tested with the VISSIM microsimulation program at different levels of the market penetration rate (MPR) of CVs. Based on the results of the experiment, the proposed strategy shows positive effects in both decreasing travel delay and increasing traffic flow even at the low levels of MPR of CVs. The results of the proposed strategy can be used as the base data for the development of smart intersection operations.

Abstract The intention of this study is to provide a critical review of single‐phase nonisolated bridgeless power factor converter topologies, which will be useful for novice researchers in the power electronics field. The bridgeless nature of the converter reduces the number of switching devices in the current path and achieves higher efficiency. Nonisolated topologies are considered in this review due to the inherent advantages they offer such as lower cost, weight and size and higher efficiency, which are desirable for systems such as on‐board electric vehicle battery chargers, direct current power supplies and variable speed drives. These topologies are derived from conventional boost, buck and buck/boost converters. Moreover, the topologies can be operated in continuous or discontinuous conduction modes subject to their applications. Each topology is described in terms of its advantages and limitations. In addition, a comparative study is conducted for each group (boost, buck and buck/boost).

Abstract Aims/hypothesis Pohang Tertiary mudstone presents the issue of acid rock drainage. This study analyzed the capacity of a mixed slag (70% steel slag + 30% blast furnace slag) to neutralize Pohang Tertiary mudstone’s acid rock drainage. Methods Element analysis, acid neutralization capacity (ANC) test, and net acid generation (NAG) test were conducted on Pohang Tertiary mudstone samples and the mixed slag. The XRF analysis and the XRD analysis on the mixed slag were conducted to measure the CaO content, which indicates the potential of the mixed slag as an acid-neutralizing agent. Results According to the analysis results on the Pohang Tertiary mudstone samples, the total sulfur content was high, which indicates a high risk of acid rock drainage generation. Although there were slight deviations between the samples, overall, the mudstone exhibited a high acid rock drainage generation capacity. The XRF analysis of mixed slag results showed high amounts of CaO content. From the XRD analysis graph, it was clear that a high proportion of minerals with Ca- compounds consisting of basic substances were present. The neutralization capacity of the mixed slag on Pohang Tertiary mudstone was determined by the relationship between maximum potential acidity (MPA) and acid neutralization capacity (ANC). For instance, the mixed slag of 4.5% effectively neutralizes a sulfur content of 1%.

This work proposes positive- and negative-sequence equivalent circuits of grid-forming inverters for steady-state analysis. The proposed models are especially attractive for performing long-duration voltage regulation analysis and short-circuit studies involving grid-forming inverters. Our proposed equivalent circuit models are based on the inverter’s voltage and current control loops in the $\alpha \beta $ and dq frames. For this reason, they operate according to prescribed control functions and specified impedances (i.e., filter impedance, current limiter block, virtual admittance block, and PI/PR controller block). The equivalent circuit model accuracy is validated by comparing system steady-state voltage and current responses obtained by detailed time-domain models in PSCAD/EMTDC to those by the equivalent circuit models implemented in steady-state load flow program (e.g., OpenDSS). Two distinct control structures implemented in the $\alpha \beta $ and dq frames are used for the validation. Single line-to-ground and line-to-line-to-ground faults are simulated in a small islanded microgrid as well as the IEEE 34-node test feeder. Fault impedances varying from 0 to 5 ohms are simulated. We show that the equivalent models precisely replicate the steady-state response of the detailed time-domain models.

Recent advances in inverter-based distributed energy resources (DERs) allow microgrids to operate in grid-connected and islanded modes with ease. However, determining a steady-state load flow solution of a real-world unbalanced and islanded three-phase microgrid remains a challenge. Existing methods are either unsuitable, labor-intensive or computationally demanding for a long-term analysis of islanded microgrids. To address these issues, we propose a practical solution framework that employs externally-updated system frequency, power quantities, and droop characteristics governing the voltage and phase angle of DERs in every iteration as inputs to an off-the-shelf open-source multi-phase, multi-wire, unbalanced power flow software tool to solve an islanded-microgrid power flow. Using our framework, users only need to implement a set of droop equations and update system variables. The power flow solution is accomplished entirely by an off-the-shelf power flow tool, e.g., OpenDSS. Our proposed framework can model a microgrid of any arbitrary configuration and operating condition. We demonstrate and validate the proposed method’s efficacy by comparing its results with those modeled using a time-domain simulation with PSCAD/EMTDC. Finally, an example of a quasi-static time-series study is presented to better illustrate the application of such a tool.

Abstract Bio ethylene propylene diene monomer (EPDM) produced with sugarcane-derived ethylene is an eco-friendly alternative material that can perform similarly to an oil-based synthetic rubber while reducing dependence on fossil resources. In this study, bio-EPDM/tungsten oxide nanocomposite was prepared to improve thermal insulation properties of bio-EPDM foam for application in highly functional eco-friendly diving wetsuits. The synthesized tungsten bronze nanorods (TBNRs) were doped with sodium and added to the bio-EPDM compound, then foam was generated by molding at 155 °C under a high-pressure. After foam molding, the effects of TBNRs on the sea water resistance as well as the thermal and mechanical properties of bio-EPDM foam were investigated. As a result, TBNRs remarkably improved the softness and photothermal properties of bio-EPDM foam without a significant reduction of their mechanical properties. Especially, the excellent dimensional stability of the bio-EPDM foam with TBNRs under the sea water circumstance highlights its superiority as a material for marine sports. Overall results indicate that the bio-EPDM foam material containing TBNRs at the optimum ratio can be fully utilized for the development of eco-friendly and high-performance wetsuit materials with excellent elasticity, flexibility, and thermal insulation properties.

Summary: Background/objective: Colonoscopy-induced colonic perforation often requires surgical management. The aim of this study was to analyze the outcomes after surgery for colonoscopic perforations (CPs). Methods: This was a retrospective chart review study of 48 patients who underwent surgery for CPs between January 2002 and May 2017. The patients were divided into two groups: Group I (n = 25) had diagnostic CPs, and Group II (n = 23) had therapeutic CPs. Results: The most common perforation sites in Group I were the sigmoid colon (n = 19; 76.0%), whereas in Group II were the transverse colon (n = 10, 43.5%) and sigmoid colon (n = 10, 43.5%; p = 0.013). The surgeries performed were primary closure (n = 16, [64.0%] Group I; n = 11 [47.8%] Group II) and bowel resection (n = 9 [36.0%] Group I; n = 11 [47.8%] Group II). The rate of temporary stomas was higher in Group II (n = 9, 26.1%) than Group I (n = 2, 8.0%; p = 0.030). The re-perforation rate after surgery was 8.0% (n = 2) in Group I and 8.7% (n = 2) in Group II (p = 0.568). These re-perforation patients all those who had a simple closure without a wedge resection. The conversion rate after laparoscopic surgery was 20.0% (n = 2 of 10) in Group I and 33.3% (n = 1 of 3) in Group II. Conclusions: Surgical management is one of the important therapies in the treatment of CP. Simple primary closure without a wedge resection should be used cautiously. Therapeutic CPs was associated with more temporary stoma formation. The type of surgery should be carefully selected, depending on the type of CP. Keywords: Colonoscopy, Perforation, Surgery, Outcomes

Residential electricity loads highly fluctuate which makes it challenging to predict and estimate changes and anomalies. This article studies the statistical distribution of the maximum load of residential settlements and proposes a new model that is more reliable than conventional methods to predict extreme events in residential electricity consumption. Specially, a multimodal Tracy-Widom distribution is proposed to characterize the maximum residential electricity consumption data. We also propose a numerical method to approximate the density function of the multimodal Tracy-Widom distribution as opposed to the conventional approach in the literature, where a multimodal normal distribution is utilized. A simulated electricity consumption data set is used to test and validate the proposed methods. The results demonstrate that the multimodal Tracy-Widom distribution is more accurate than conventional methods in modeling residential electricity consumption data. In addition, the numerical results show that residential electricity consumption behavior is determined by certain socioeconomic factors for which correlations with household electricity consumption exist.

Some rotors are bent permanently due to high operating temperatures, repeated transition periods, and so on. Rotors with large deformations often require straightening processes. The goal of this study is to develop a method to determine the optimal locations and strengths of hammer peening for straightening gas turbine rotors. A set of parametric hammer peening simulations were performed for various dimensions of straight rotors and peening locations. The deformed geometries of the rotor from the parametric simulations were presented as curvature vectors. These curvature vectors were fitted using an empirical function. For a given initial geometry of the rotor and hammer peening plans, the post-peening geometry of the rotor was predicted by superimposing the initial curvature and newly induced curvature. An optimization statement was defined to determine a set of hammer peening locations and strengths. Constraints were imposed to exclude areas where hammer peening could not be performed such as locations for bearings. The proposed method provides an optimal hammer peening plan for the given runout data. The proposed method was validated against a series of hammer peening test results for a simple shaft. The developed method can be applied to other types of rotor straightening methods such as hot spotting.

This paper proposes a novel input power factor control method based on a concept of virtual capacitors to provide unity input power factor for three-phase matrix rectifiers. The proposed algorithm introduces, at the input terminal of the matrix rectifier, an imaginary input capacitor generated by modifying a reference vector of the space vector modulation method. The virtual input capacitor, which is fictitiously built in parallel with an input LC filter, successfully compensates for the leading power factor of the LC filter of the matrix rectifier. Thus, the proposed method yields a unity power factor operation despite the presence of the LC filter of the three-phase matrix rectifier. In addition, under a condition when the unity power factor operation cannot be realized, the proposed algorithm adjusts a virtual capacitance to obtain a maximum achievable power factor operation. Because the proposed technique yields the input power factor control by introducing the virtual capacitor and adjusting a reference space vector, the proposed algorithm can be easily incorporated with conventional space vector modulation algorithms for the three-phase matrix rectifiers. Thus, the proposed method can control input power factor without employing proportional-integral controllers used in conventional power factor control methods for the matrix rectifiers, leading to simple control structure and straightforward tuning process for power factor control.

This paper presents switch fault detection and compensation control schemes for a modified dc-dc converter that relocates a diode location. The proposed fault detection and compensation control schemes are applicable to various energy generation systems that include energy storage. A fault detection index has been introduced to detect an open switch fault in the modified converter structure, and a compensation control method based on a mixed switching strategy has been developed. The fault-tolerant control method along with the detection scheme can make a system return to work even under a switch fault. The proposed schemes have been tested and verified both by the simulations and by experiments using a TMS320F28335 DSP. The results will significantly improve the reliability of alternative energy generation systems against open switch faults.

This paper presents a new concurrent control structure for a novel non-isolated triple-output converter with energy storage utilizing a time-sharing switching technique. The proposed structure and control feature single-stage power conversion for a DC input, energy storage, and three output ports while reducing the number of switching elements. To employ fewer switches and to have a continuous battery current, a new time-sharing switching method is proposed for two switches in the converter. Based on the proposed control method, the two switches can manage the main inductor current and a battery current concurrently, which in turn creates room to use fewer switching elements. Therefore, the proposed converter structure is compact but fully functional by integrating fundamental converters utilizing the new time-sharing control method. Various applications that have a single DC input and multiple DC outputs along with energy storage can benefit from the proposed structure and control strategies. The fundamentals of the proposed circuits and the concurrent control concept are explained in detail. Then, the feasibility of the proposed approach is validated both by experiments and by simulations.

High modularity, easy scalability, and superior harmonic performance, comprising the topology with the most potential for medium- to high-voltage high-power applications, are representative features of a modular multilevel converter (MMC). Each application of a MMC requires a proper scheme such that it conforms to control objectives such as correct submodule capacitor voltage balancing control and the suppression of circulating current. Over the past few years, various studies have been presented that meet the MMC requirements through both classical control-based pulse-width modulation and model predictive control, although some drawbacks exist for both control concepts. The dynamic performance of the classical control methods with proportional-integral or proportional-resonant controllers is unsatisfactory, and the requirement of proportional-integral parameters tuning procedure makes converter operation performance depends on proportional-integral parameters adjustment. Meanwhile, model predictive control performance depends significantly on the mathematical model of a system, and weighting factor selection is tedious. In this paper, we propose an improved phase-shifted carrier pulse-width modulation method and capacitor voltage balancing control that inherits the merits from both classical control and model predictive control. Meanwhile, the proposed control method eliminates the requirement of the tedious proportional-integral parameters tuning procedure and improves the dynamic performance compared with the conventional phase-shifted carrier pulse-width modulation-based proportional-integral controller method. Simulations and experiments were conducted to demonstrate the proposed method's properness.

Research on the magnetic levitation driving system of Hyperloop which has emerged as the next new vehicle is being carried out. Recently, magnetic levitation driving systems use EMS (Electro-Magnetic Suspension) and EDS (Electro-Dynamic Suspension) methods, and both EMS and EDS methods use two or more systems for propulsion/levitation/guidance. However, using two or more driving systems cause complexity of structure of whole system and increase significantly maintenance costs. Therefore, to solve these problems, this study proposed the concept and structure of Double-Sided Linear Induction Motor (DSLIM) that can be generating propulsion/levitation/guidance in one system, and carried out basic design and performance analysis by analyzing the design requirements of DSLIM. In addition, a detailed design through the selection of design parameters and analysis of characteristics that significantly affect the output characteristics was carried out to derive a performance improvement model for DSLIM.

Unlike the conventional railway traction motor, the concept of the dual-rotor in a dual-rotor permanent magnet synchronous motor (DR-PMSM) is that two rotors are mounted on the same rotation axis, and the outer rotor and the inner rotor rotate at different speeds. The DR-PMSM can transmit the power to the wheels in a structure that can cope with various problems of the reducer systems using mechanical gear mechanisms. In this research, the design study of the inner rotor including the permanent magnet is carried out in the application of the DR-PMSM. In designing the DR-PMSM models, surface permanent magnet (SPM) type and interior permanent magnet (IPM) type are considered according to the permanent magnet type of rotor, and IPM type is designed by dividing into bar type and V type. A comparative analysis of the three 1kW-class DR-PMSM models, in terms of electromagnetic properties, is performed to assess their general performance. The overall electromagnetic properties of the three designed models are similarly derived. But, the cogging torque and the rated torque characteristics of the IPM (V) type model are the best in comparison with the other models. In addition, the 1kW-class DR-PMSM prototype with V type magnet is fabricated to verify the validity of the analytical model and performance verification is performed.

Conventional diesel railway vehicles produce many air pollutants. In order to solve this problem, railway vehicles using eco-friendly hydrogen fuel cells are emerging. The main difference from the conventional traction motor is that it does not control the phase back electromotive force (phase-BEMF) separately at the maximum speed. Because of this, it should reduce the use of permanent magnets yet increase their size due to necessary high current. This paper performs the interior permanent magnet synchronous motor (IPMSM) design to meet the harsh electrical and mechanical constraints. Although the basic design is carried out to satisfy the design constraints, structural problems occur. These are resolved through the optimization process to attain the optimal design of a 314kW-class IPMSM for railway vehicles using hydrogen fuel cells.

Nafamostat, a synthetic serine protease inhibitor, has been used for the treatment of inflammatory diseases such as pancreatitis. Recently, an increasing number of studies have shown the promising antiviral effects of nafamostat for the treatment of coronavirus disease-19 (COVID-19). This study aimed to develop a novel liquid chromatography–tandem mass spectrometry (LC-MS/MS) analysis and to characterize the pharmacokinetics of nafamostat in rats. Nafamostat in the rat plasma was extracted by solid phase extraction, and 13C6-nafamostat was used as an internal standard. The quantification limit of nafamostat in the rat plasma was 0.5 ng/mL. The LC-MS/MS method was fully validated and applied to characterize the pharmacokinetics of nafamostat in rats. Following intravenous injection (2 mg/kg), nafamostat in the plasma showed a multiexponential decline with an average elimination half-life (t1/2) of 1.39 h. Following oral administration of nafamostat solutions (20 mg/kg) in 10% dimethyl sulfoxide (DMSO) and in 10% DMSO with 10% Tween 80, nafamostat was rapidly absorbed, and the average oral bioavailability was 0.95% and 1.59%, respectively. The LC-MS/MS method and the pharmacokinetic information of nafamostat could be helpful for the further preclinical and clinical studies of nafamostat.

The development of gel polymer electrolytes (GPEs) for lithium-ion batteries (LIBs) has paved the way to powering futuristic technological applications such as hybrid electric vehicles and portable electronic devices. Despite their multiple advantages, non-aqueous liquid electrolytes (LEs) possess certain drawbacks, such as plasticizers with flammable ethers and esters, electrochemical instability, and fluctuations in the active voltage scale, which limit the safety and working span of the batteries. However, these shortcomings can be rectified using GPEs, which result in the enhancement of functional properties such as thermal, chemical, and mechanical stability; electrolyte uptake; and ionic conductivity. Thus, we report on PVDF-HFP/PMMA/PVAc-based GPEs comprising poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-co-HFP) and poly(methyl methacrylate) (PMMA) host polymers and poly(vinyl acetate) (PVAc) as a guest polymer. A physicochemical characterization of the polymer membrane with GPE was conducted, and the electrochemical performance of the NCM811/Li half-cell with GPE was evaluated. The GPE exhibited an ionic conductivity of 4.24 × 10−4 S cm−1, and the NCM811/Li half-cell with GPE delivered an initial specific discharge capacity of 204 mAh g−1 at a current rate of 0.1 C. The cells exhibited excellent cyclic performance with 88% capacity retention after 50 cycles. Thus, this study presents a promising strategy for maintaining capacity retention, safety, and stable cyclic performance in rechargeable LIBs.

Active front-end rectifiers are tasked with generating high-quality, low-distortion sinusoidal line currents in the presence of adverse circuit conditions. When suitable control methods are applied to such rectifiers, significant performance improvements can be realized, especially under abnormal utility conditions. Although several control methods based on model predictive control platforms have been recently developed, there is a lack of comparative studies of these methods in the literature. In this paper, the details and theoretical background of four model predictive control methods, namely, current control, virtual flux control, direct power control, and virtual flux direct power control, are presented. Then, the performance of these methods was compared by the way of experiments to determine the respective quality of the line current under various conditions, such as unbalanced input voltages, input voltage distortion, uncertainty in the parameters, and dc voltage fluctuation. In summary, based on the results of the experiments, the virtual flux control scheme was found to be distinctly superior to the other three schemes for distorted and unbalanced line voltages.

For accurate and fast detection of facial landmarks, we propose a new facial landmark detection method. Previous facial landmark detection models generally perform a face detection step before landmark detection. This greatly affects landmark detection performance depending on which face detection model is used. Therefore, we propose a model that can simultaneously detect a face region and a landmark without performing the face detection step before landmark detection. The proposed single-shot detection model is based on the framework of YOLOv3, a one-stage object detection method, and the loss function and structure are altered to learn faces and landmarks at the same time. In addition, EfficientNet-B0 was utilized as the backbone network to increase processing speed and accuracy. The learned database used 300W-LP with 64 facial landmarks. The average normalized error of the proposed model was 2.32 pixels. The processing time per frame was about 15 milliseconds, and the average precision of face detection was about 99%. As a result of the evaluation, it was confirmed that the single-shot detection model has better performance and speed than the previous methods. In addition, as a result of using the COFW database, which has 29 landmarks instead of 64 to verify the proposed method, the average normalization error was 2.56 pixels, which was also confirmed to show promising performance.

Purpose The study aimed to analyze peri/postoperative outcomes and long-term oncologic outcomes after surgical management for primary gastrointestinal diffuse large B-cell lymphoma (DLBL). Methods Between January 2001 and December 2013, 19 patients who underwent surgery for primary gastrointestinal DLBL were retrieved from a retrospective database. Results With a median follow up of 49.2 months, the most common tumor locations were the terminal ileum and cecum (n=14, 73.7%) and stomach (n=4, 21.1%). The most common clinical symptoms were abdominal pain (n=15, 78.9%) and intussusceptions (n=5, 26.3%). None of the patients had B symptoms. Emergency surgery was undertaken in 36.8% (n=7) of the patients. Mean mass size was 8.4 cm; 4 patients (21.1%) had a bulky mass (>10 cm). The International Prognostic Index (IPI) scores were low (n=11, 57.9%), low-intermittent (n=7, 36.8%), and high-intermittent (n=1, 5.3%). Patients’ staging was IE (n=9, 47.4%), IIE (n=8, 42.1%), and IVE (n=2, 10.5%) based on the Ann Arbor staging system, and I (n=2, 10.5%), II1 (n=5, 26.4%), IIE (n=10, 52.6%), and IV (n=2, 10.5%) based on the Lugano staging system. B-lymphocyte antigen CD20 was positive in most patients (n=17, 89.5%) and Ki-67 was high (>70%) in 12 patients (63.2%). Two types of chemotherapy were administered: cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisolone (n=5, 26.3%), rituximab, cy-clophosphamide, hydroxydaunorubicin, oncovin, and prednisolone (n=13, 68.4%). The 5-year disease-free survival rate was 94.4% and the 5-year overall survival rate was 89.5%. Conclusion Surgery for primary gastrointestinal DLBL is feasible and acceptable. Low staging of primary gastrointestinal DLBL has good prognosis.

Disruption of protein quality control can be detrimental, having toxic effects on single cell organisms and contributing to neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Huntington’s in humans. Here, we examined the effects of polyglutamine (polyQ) aggregation in a major fungal pathogen of humans, Candida albicans, with the goal of identifying new approaches to disable this fungus. However, we discovered that expression of polyQ stretches up to 230Q had no effect on C. albicans ability to grow and withstand proteotoxic stress. Bioinformatics analysis demonstrates that C. albicans has a similarly glutamine-rich proteome to the unicellular fungus Saccharomyces cerevisiae, which exhibits polyQ toxicity with as few as 72Q. Surprisingly, global transcriptional profiles indicated no significant change upon induction of up to 230Q. Proteomic analysis highlighted two key interactors of 230Q, Sis1 and Sgt2; however, loss of either protein had no additional effect on C. albicans toxicity. Our data suggest that C. albicans has evolved powerful mechanisms to overcome the toxicity associated with aggregation-prone proteins, providing a unique model for studying polyQ-associated diseases.

Oxidative stress and inflammation are key pathways responsible for the pathogenesis of asthma. Aquatic exercise (AE) has been proven to elicit a variety of biological activities such as anti-oxidant and anti-inflammatory effects. However, although proper forms of AE provide beneficial health effects, incorrect forms and types of AE are potentially injurious to health. Several studies have investigated AE, but the relationship between types of AE and asthma has not been fully elucidated. This study evaluated the effects of two types of AE according to resistance on ovalbumin (OVA)-induced allergic airway inflammation in mice. BALB/c mice were subjected to OVA sensitization and challenge, and then to different types of AE including, walking and swimming, in a pool filled with water to a height of 2.5 and 13 cm for 30 min, respectively. AE reduced OVA-induced eosinophilic inflammation, airway hyperresponsiveness, and serum immunoglobulin E level. AE significantly inhibited increases in interleukin (IL)-4, IL-5, IL-13, histamine, leukotriene D4, and tryptase levels in bronchoalveolar lavage fluid (BALF). AE also effectively suppressed mucus formation, lung fibrosis, and hypertrophy of airway smooth muscle within the lung tissues. This exercise markedly reduced the levels of malondialdehyde while increased glutathione and superoxide dismutase (SOD) activity in lung tissues. Furthermore, AE significantly decreased tumor necrosis factor-α, IL-6 levels, and prostaglandin E2 production in BALF. The inhibitory effects of swimming on the levels of biomarkers related to oxidative stress and inflammation were greater than that of walking. These effects may have occurred through upregulation of NF-E2-related factor 2/heme oxygenase-1 signaling and suppression of mitogen-activated protein kinase/nuclear factor-κB pathway. Cumulative results from this study suggest that AE might be beneficial in mitigating the levels of biomarkers related to oxidative stress and inflammation. Thus, this therapy represents a crucial non-pharmacological intervention for treatments of allergic airway inflammation.

This study aims at creating low-cost, three-dimensional (3D), freehand ultrasound image reconstructions from commercial two-dimensional (2D) probes. The low-cost system that can be attached to a commercial 2D ultrasound probe consists of commercial ultrasonic distance sensors, a gimbal, and an inertial measurement unit (IMU). To calibrate irregular movements of the probe during scanning, relative position data were collected from the ultrasonic sensors that were attached to a gimbal. The directional information was provided from the IMU. All the data and 2D ultrasound images were combined using a personal computer to reconstruct 3D ultrasound image. The relative position error of the proposed system was less than 0.5%. The overall shape of the cystic mass in the breast phantom was similar to those from 2D and sections of 3D ultrasound images. Additionally, the pressure and deformations of lesions could be obtained and compensated by contacting the probe to the surface of the soft tissue using the acquired position data. The proposed method did not require any initial marks or receivers for the reconstruction of a 3D ultrasound image using a 2D ultrasound probe. Even though our system is less than $500, a valuable volumetric ultrasound image could be provided to the users.

As the use of electronic displays increases rapidly, visual fatigue problems are also increasing. The subjective evaluation methods used for visual fatigue measurement have individual difference problems, while objective methods based on bio-signal measurement have problems regarding motion artifacts. Conventional eye image analysis-based visual fatigue measurement methods do not accurately characterize the complex changes in the appearance of the eye. To solve this problem, in this paper, an objective visual fatigue measurement method based on infrared eye image analysis is proposed. For accurate pupil detection, a convolutional neural network-based semantic segmentation method was used. Three features are calculated based on the pupil detection results: (1) pupil accommodation speed, (2) blink frequency, and (3) eye-closed duration. In order to verify the calculated features, differences in fatigue caused by changes in content color components such as gamma, color temperature, and brightness were compared with a reference video. The pupil detection accuracy was confirmed to be 96.63% based on the mean intersection over union. In addition, it was confirmed that all three features showed significant differences from the reference group; thus, it was verified that the proposed analysis method can be used for the objective measurement of visual fatigue.

We investigated the liquid crystal (LC) alignment behaviors of butyl hydroxybenzoate-substituted polystyrene (PBHB#; # = 20, 40, 60, 80, and 100, where # indicates the molar fraction of butyl hydroxybenzoate in the side chain), methyl hydroxybenzoate-substituted polystyrene (PMHB100), and ethyl hydroxybenzoate-substituted polystyrene (PEHB100). Generally, LC cells made employing polymer films having longer alkyl groups in the side chain show vertical LC alignment. For instance, a LC cell fabricated with the PMHB100 film showed random planar LC alignment, while the LC cells made from the PEHB100 and PBHB100 films exhibited vertical LC alignment. Moreover, LC cells prepared from a polymer film having a higher molar content of butyl hydroxybenzoate in the side chain exhibited vertical LC alignment. The observed vertical LC alignment behaviors are closely related to the surface energy of these polymer films. For instance, vertical LC alignment was observed when the surface energy of the polymer film was less than ~43.86 mJ/m2, which could result from the nonpolar alkyl groups of the alkyl hydroxybenzoate moiety. The LC cell prepared from PBHB100 as the LC alignment layer showed good electro-optical characteristics such as voltage holding ratio, residual DC voltage, and alignment stability at 200 °C.

On 15th November 2017, the Pohang earthquake (Mw 5.4) had strong ground shaking that caused severe liquefaction and lateral spreading across the Heunghae Basin, around Pohang city, South Korea. Such liquefaction is a rare phenomenon during small or moderate earthquakes (MW < 5.5). There are only a few examples around the globe, but more so in the Korean Peninsula. In this paper, we present the results of a systematic survey of the secondary ground effects—i.e., soil liquefaction and ground cracks—developed during the earthquake. Most of the liquefaction sites are clustered near the epicenter and close to the Heunghae fault. Based on the geology, tectonic setting, distribution, and clustering of the sand boils along the southern part of the Heunghae Basin, we propose a geological model, suggesting that the Heunghae fault may have acted as a barrier to the propagation of seismic waves. Other factors like the mountain basin effect and/or amplification of seismic waves by a blind thrust fault could play an important role. Liquefaction phenomenon associated with the 2017 Pohang earthquake emphasizes that there is an urgent need of liquefaction potential mapping for the Pohang city and other areas with a similar geological setting. In areas underlain by extensive unconsolidated basin fill sediments—where the records of past earthquakes are exiguous or indistinct and there is poor implementation of building codes—future earthquakes of similar or larger magnitude as the Pohang earthquake are likely to occur again. Therefore, this represents a hazard that may cause significant societal and economic threats in the future.

Distillation is one of the dominating separation processes, but there are some problems as inseparable mixtures areformed in some cases. This phenomenon is called as azeotropy. It is essential to understand azeotropy in any distillationprocesses since azeotropes, i.e. inseparable mixtures, cannot be separated by ordinary distillation. In this study, to constructa model which predicts the azeotropic formation at any pressure, a novel approach using support vector machine (SVM) ispresented. The SVM method is used to classify data in the two classes, that is, azeotropes and non-azeotropes. 13 variables,including pressure, were used as explanatory variables in this model. From the result of the SVM models which were constructed with data measured at 1 atm and data measured at all pressures, the 1 atm model showed a higher prediction performance to the data measured at 1 atm than the all pressure model. Thus, for improving the performance of the all pressuremodel, we focused on intermolecular forces of solvents. The SVM models were constructed with only data of the solventshaving same subgroups. The accuracy of the model increased and it is expected that this proposed method will be used topredict azeotropic formation at any pressure with high accuracy.

Various control methods and applications have been introduced to power systems in order to alleviate the uncertainties of relying on renewable sources. This paper, focusing on a reactive power allocation process, discusses the development of a self-modification algorithm and its introduction to an online reference management system. The algorithm is designed to predict unexpected situations occurring in real-time operations, when, due to technical issues, the control system becomes unavailable. A test system has been formed to check the feasibility of the composed method. As the main purpose of the feasibility study is checking availability with a complex solution, case studies are designed to adapt a reactive power allocation method based on loss minimization. When unexpected systemic errors were induced, the proposed modification plan changed order automatically with maintaining previous objective function. The improved effects, caused by realistic responses, are classified according to EMTDC (Electro-Magnetic Transient Design and Control) analysis.

Power generation systems based on the oxy-coal combustion with carbon dioxide capture and storage (CCS) capability are being proposed and discussed lately. The proposed systems are evolving and various alternatives are to be comparatively evaluated. This paper presents a proposed approach for performance evaluation of a commercial scale power plant, which is currently being considered for ‘retrofitting’ for the demonstration of the concept. System components to be included in the discussion are listed. Evaluation criteria in terms of performance and economics are summarized based on the system heat and mass balance and simple performance parameters such as the fuel to power efficiency and brief introduction of the 2nd law analysis. Cases are selected for comparative evaluation, based on the site-specific requirements. With limited information available, preliminary evaluation is attempted for the cases.

Intrinsically disordered regions have been associated with various cellular processes and are implicated in several human diseases, but their exact roles remain unclear. We previously defined two classes of conserved disordered regions in budding yeast, referred to as "flexible" and "constrained" conserved disorder. In flexible disorder, the property of disorder has been positionally conserved during evolution, whereas in constrained disorder, both the amino acid sequence and the property of disorder have been conserved. Here, we show that flexible and constrained disorder are widespread in the human proteome, and are particularly common in proteins with regulatory functions. Both classes of disordered sequences are highly enriched in regions of proteins that undergo tissue-specific (TS) alternative splicing (AS), but not in regions of proteins that undergo general (i.e., not tissue-regulated) AS. Flexible disorder is more highly enriched in TS alternative exons, whereas constrained disorder is more highly enriched in exons that flank TS alternative exons. These latter regions are also significantly more enriched in potential phosphosites and other short linear motifs associated with cell signaling. We further show that cancer driver mutations are significantly enriched in regions of proteins associated with TS and general AS. Collectively, our results point to distinct roles for TS alternative exons and flanking exons in the dynamic regulation of protein interaction networks in response to signaling activity, and they further suggest that alternatively spliced regions of proteins are often functionally altered by mutations responsible for cancer.

Variations in gene expression level might lead to phenotypic diversity across individuals or populations. Although many human genes are found to have differential mRNA levels between populations, the extent of gene expression that could vary within and between populations largely remains elusive. To investigate the dynamic range of gene expression, we analyzed the expression variability of ∼18, 000 human genes across individuals within HapMap populations. Although ∼20% of human genes show differentiated mRNA levels between populations, our results show that expression variability of most human genes in one population is not significantly deviant from another population, except for a small fraction that do show substantially higher expression variability in a particular population. By associating expression variability with sequence polymorphism, intriguingly, we found SNPs in the untranslated regions (5' and 3'UTRs) of these variable genes show consistently elevated population heterozygosity. We performed differential expression analysis on a genome-wide scale, and found substantially reduced expression variability for a large number of genes, prohibiting them from being differentially expressed between populations. Functional analysis revealed that genes with the greatest within-population expression variability are significantly enriched for chemokine signaling in HIV-1 infection, and for HIV-interacting proteins that control viral entry, replication, and propagation. This observation combined with the finding that known human HIV host factors show substantially elevated expression variability, collectively suggest that gene expression variability might explain differential HIV susceptibility across individuals.