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It is a very complicated process for electric aircraft airplane to run from take-off acceleration to flight to a safe altitude.When calculating the take-off performance of an electric aircraft, it is found that the take-off distance obtained by the approximately uniform acceleration simulation model is always smaller than the actual take-off distance.In order to accurately calculate the take-off performance of electric aircraft, a simulation model of the complete take-off process is established in MATLAB, and the error between the model and the actual take-off process is analyzed.By analyzing the change rule of acceleration and speed during the take-off process of electric aircraft, a modification function is introduced to modify the speed in the model.Taking an electric aircraft takeoff performance calculation as an example, the model before and after the modification is used to simulate the takeoff process and compare the calculation results with the flight test data.The results show that the accuracy of the modified model is better than the simulation model before modification, and the simulation results of the revised model are basically consistent with the results of the aircraft flight test.

AbstractObjective The study aimed to compare the effectiveness and safety of ultrasound-guided microwave ablation (MWA) and percutaneous sclerotherapy (PS) for the treatment of large hepatic hemangioma (LHH).Methods This retrospective study included 96 patients who underwent MWA (n = 54) and PS (n = 42) as first-line treatment for LHH in three tertiary hospitals from January 2016 to December 2021. Primary outcomes were technique efficacy rate (volume reduction rate [VRR] > 50% at 12 months), symptom relief rate at 12 months and local tumor progression (LTP). Secondary outcomes included procedure time, major complications, treatment sessions, cost and one-, two-, three-year VRR.Results During a median follow-up of 36 months, the MWA group showed a higher technique efficacy rate (100% vs. 90.4%, p = .018) and symptom relief rate (100% vs. 80%, p = .123) than the PS group. The MWA group had fewer treatment sessions, higher one-, two- and three-year VRR, lower LTP rate (all p 8.1 cm were independent risk factors for LTP (all p 0.115 mg/cm3 had a lower risk of LTP (p = .006).Conclusions Both MWA and PS treatments for large hepatic hemangioma are safe and effective, with MWA being superior in terms of efficacy.

Abstract K+ channel interacting protein 1 (KChIP1) is a neuronal calcium sensor (NCS) protein that interacts with multiple intracellular molecules. Its physiological function, however, remains largely unknown. We report that KChIP1 is predominantly expressed at GABAergic synapses of a subset of parvalbumin-positive neurons in the brain. Forced expression of KChIP1 in cultured hippocampal neurons increased the frequency of miniature inhibitory postsynaptic currents (mIPSCs), reduced paired pulse facilitation of autaptic IPSCs, and decreases potassium current density. Furthermore, genetic ablation of KChIP1 potentiated potassium current density in neurons and caused a robust enhancement of anxiety-like behavior in mice. Our study suggests that KChIP1 is a synaptic protein that regulates behavioral anxiety by modulating inhibitory synaptic transmission, and drugs that act on KChIP1 may help to treat patients with mood disorders including anxiety.

Abstract Background Classical swine fever (CSF) caused by virulent strains of Classical swine fever virus (CSFV) is a haemorrhagic disease of pigs, characterized by disseminated intravascular coagulation, thrombocytopoenia and immunosuppression, and the swine endothelial vascular cell is one of the CSFV target cells. In this report, we investigated the previously unknown subcellular localization and function of CSFV NS2 protein by examining its effects on cell growth and cell cycle progression. Results Stable swine umbilical vein endothelial cell line (SUVEC) expressing CSFV NS2 were established and showed that the protein localized to the endoplasmic reticulum (ER). Cellular analysis revealed that replication of NS2-expressing cell lines was inhibited by 20-30% due to cell cycle arrest at S-phase. The NS2 protein also induced ER stress and activated the nuclear transcription factor kappa B (NF-κB). A significant increase in cyclin A transcriptional levels was observed in NS2-expressing cells but was accompanied by a concomitant increase in the proteasomal degradation of cyclin A protein. Therefore, the induction of cell cycle arrest at S-phase by CSFV NS2 protein is associated with increased turnover of cyclin A protein rather than the down-regulation of cyclin A transcription. Conclusions All the data suggest that CSFV NS2 protein modulate the cellular growth and cell cycle progression through inducing the S-phase arrest and provide a cellular environment that is advantageous for viral replication. These findings provide novel information on the function of the poorly characterized CSFV NS2 protein.

The neutron skin thickness Δr_{np} of heavy nuclei is essentially determined by the symmetry energy density slope L(ρ) at ρ_{c}=0.11fm^{−3}≈2/3ρ_{0} (ρ_{0} is nuclear saturation density), roughly corresponding to the average density of finite nuclei. The PREX collaboration recently reported a model-independent extraction of Δr_{np}^{208}=0.283±0.071 fm for the Δr_{np} of ^{208}Pb, suggesting a rather stiff symmetry energy E_{sym}(ρ) with L(ρ_{c})≥52 MeV. We show that the E_{sym}(ρ) cannot be too stiff and L(ρ_{c})≤73 MeV is necessary to be compatible with (1) the ground-state properties and giant monopole resonances of finite nuclei, (2) the constraints on the equation of state of symmetric nuclear matter at suprasaturation densities from flow data in heavy-ion collisions, (3) the largest neutron star (NS) mass reported so far for PSR J0740+6620, (4) the NS tidal deformability extracted from gravitational wave signal GW170817, and (5) the mass-radius of PSR J0030+045 measured simultaneously by NICER. This allows us to obtain 52≤L(ρ_{c})≤73 MeV and 0.212≤Δr_{np}^{208}≤0.271 fm and further E_{sym}(ρ_{0})=34.3±1.7 MeV, L(ρ_{0})=83.1±24.7 MeV, and E_{sym}(2ρ_{0})=62.8±15.9 MeV. A number of critical implications on nuclear physics and astrophysics are discussed.