91 results on '"TEOFILINA"'
Search Results
2. The use of chitosan as an effective carrier of theophylline – an anti-asthmatic drug.
- Author
-
Aziz, Noor Firas, Hussein-Al-Ali, Samer Hasan, Ghareeb, Mowafaq Mohammed, and Nashwan, Nashwan Abdallah
- Subjects
ANTIASTHMATIC agents ,THEOPHYLLINE ,CHITOSAN ,FOURIER transform infrared spectroscopy ,FIELD emission electron microscopy ,ZETA potential ,METHYLXANTHINES - Abstract
Copyright of Polimery is the property of Industrial Chemistry Research Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
- Full Text
- View/download PDF
3. Opioid-free general anesthesia and induced recovery from anesthesia in a patient with myotonic dystrophy type-1: a case report
- Author
-
Hande Gurbuz and Kemal Tolga Saracoglu
- Subjects
Período de recuperação da anestesia ,Despertar prolongado da anestesia ,Dexmedetomidina ,Cateter para troca de tubo traqueal ,Distrofia miotônica ,Teofilina ,Anesthesiology ,RD78.3-87.3 - Abstract
Myotonic dystrophy type-1 (Steinert disease) is an autosomal dominant, progressive multisystem disease in which myotonic crisis can be triggered by several factors including pain, emotional stress, hypothermia, shivering, and mechanical or electrical stimulation. In this report, dexmedetomidine-based general anesthesia, in combination with a thoracic epidural for laparoscopic cholecystectomy in a patient with Steinert disease, is presented. An Aintree intubation catheter with the guidance of a fiberoptic bronchoscope was used for intubation to avoid laryngoscopy. Prolonged anesthetic effects of propofol were reversed, and recovery from anesthesia was accelerated using an intravenous infusion of theophylline. Resumo: A Distrofia Miotônica (DM) tipo-1 (Doença de Steinert) é uma doença multissistêmica progressiva autossômica dominante em que a crise miotônica pode ser desencadeada por vários fatores incluindo dor, estresse emocional, hipotermia, tremores e estímulo mecânico ou elétrico. O presente relato descreve anestesia geral realizada com dexmedetomidina em combinação com peridural torácica para colecistectomia laparoscópica em paciente com Doença de Steinert. Para evitar laringoscopia, a intubação traqueal foi realizada utilizando cateter de intubação Aintree guiado por broncofibroscopia óptica. Os efeitos anestésicos prolongados do propofol foram revertidos e a recuperação anestésica foi acelerada pelo uso de infusão intravenosa de teofilina.
- Published
- 2020
- Full Text
- View/download PDF
4. Teofilina para o Alívio da Dispneia Relacionada ao Ticagrelor
- Author
-
Marcelo Sanmartin-Fernandez and Jose Luis Zamorano
- Subjects
Ticagrelor ,Teofilina ,Síndrome Coronariana Aguda ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2021
- Full Text
- View/download PDF
5. Optical aptasensor for in situ detection and quantification of methylxanthines in Ilex guayusa.
- Author
-
León, Briggitte, Mollocana, Diana, Calderón, Diana, Montero-Oleas, Andrea, and de Lourdes Torres, María
- Subjects
METHYLXANTHINES ,CULTIVARS ,THEOPHYLLINE ,PHYSIOLOGICAL stress ,PLANT metabolites ,DETECTION limit - Abstract
Copyright of Avances en Ciencias e Ingeniería is the property of Avances en Ciencias e Ingenieria and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
- Full Text
- View/download PDF
6. EFECTO CITOTOXICO DE TEOFILINA EN COMBINACIÓN CON CLOROQUINA Ó QUINACRINA EN CÉLULAS DE GLIOMA C6.
- Author
-
Rita Judit, Zavaleta-Garcia, Miguel, Hernández-Cerón, Julio, Sotelo, and Roxana, Magaña-Maldonado
- Subjects
- *
COMBINATION drug therapy , *GLIOMAS , *THEOPHYLLINE , *CHLOROQUINE , *TREATMENT effectiveness , *CONFERENCES & conventions , *CELL lines , *ANTIMALARIALS , *PHARMACODYNAMICS - Abstract
Objetivo: Determinar el efecto citotóxico, así como el grado de interacción farmacológica de teofilina en combinación con cloroquina ó quinacrina sobre células de glioma C6. Antecedentes: A pesar de las estrategias convencionales de tratamiento para Glioblastoma (GB), este tumor sigue representando un reto para la medicina moderna debido a que posee mecanismos de evasión inmunológica, quimio-resistencia y gran heterogeneidad celular. Con la finalidad de proponer nuevas alternativas y combinaciones farmacológicas, se ha propuesto el reposicionamiento farmacológico de teofilina (Teo), fármaco con propiedades antineoplásicas, el cual induce autofagia mediante la vía PTEN y PI3K/AKT en células de cáncer gástrico. La autofagia se ve comprometida por adición de inhibidores en combinación con quimioterapia, resultando en acumulación de vacuolas autofágicas tóxicas e ineficaces, que conducen a muerte celular. En el presente trabajo se analizó el efecto de Cloroquina (Cq) ó quinacrina (Qc) en combinación con Teo con la finalidad de potenciar su citotoxicidad en las células tumorales de glioma C6. Métodos: Mediante ensayos in vitro se evaluó el efecto de Theo en combinación con Cq ó Qc en células de glioma C6. Las células se trataron con Teo (0.312-10 mM), Cq (0.004 - 0.300 mM) y Qc (0.001 - 0.100 mM) en tiempos de 24, 48 y 72 h para determinar viabilidad celular mediante MTT, concentración inhibitoria 50 (CI50) y análisis morfológico por microscopia de campo claro. Se evaluó el efecto sinérgico de las combinaciones mediante el programa Compusyn. Se realizaron los ensayos de inhibición de autofagia para determinar el efecto de Teo en combinación con Cq ó Qc sobre viabilidad celular. Núm. de registro del protocolo: 23/20 Resultados: Los resultados mostraron una disminución de la viabilidad celular en células de glioma C6 a 48 h, determinando la CI50 de Teo (3mM), Cq (0.125 mM) y Qc (0.025 mM). Teo en combinación con Cq o Qc disminuyó la viabilidad celular de manera dosis dependiente, y el análisis en Compusyn determinó un efecto sinérgico. Además, cuando la autofagia inducida por Teo es inhibida por Cq ó Qc, se incrementa la citotoxicidad en las células de glioma. Conclusiones: Teo en combinación con Cq ó Qc presenta un efecto citotóxico y sinérgico en células de glioma C6, este efecto se incrementa al inhibir la autofagia. Sin embargo, se requieren estudios adicionales in vitro e in vivo para describir el mecanismo de acción de Teo como potencial terapia contra el GB. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
7. Anestesia geral sem opioide e recuperação induzida da anestesia em paciente com distrofia miotônica tipo‐1: relato de caso.
- Author
-
Gurbuz, Hande and Saracoglu, Kemal Tolga
- Subjects
DEXMEDETOMIDINE ,MYOTONIA atrophica - Abstract
A Distrofia Miotônica (DM) tipo‐1 (Doença de Steinert) é uma doença multissistêmica progressiva autossômica dominante em que a crise miotônica pode ser desencadeada por vários fatores, incluindo dor, estresse emocional, hipotermia, tremores e estímulo mecânico ou elétrico. O presente relato descreve anestesia geral realizada com dexmedetomidina em combinação com peridural torácica para colecistectomia laparoscópica em paciente com Doença de Steinert. Para evitar laringoscopia, a intubação traqueal foi realizada utilizando cateter de intubação Aintree guiado por broncofibroscopia óptica. Os efeitos anestésicos prolongados do propofol foram revertidos e a recuperação anestésica foi acelerada pelo uso de infusão intravenosa de teofilina. Myotonic dystrophy type‐1 (Steinert disease) is an autosomal dominant, progressive multisystem disease in which myotonic crisis can be triggered by several factors including pain, emotional stress, hypothermia, shivering, and mechanical or electrical stimulation. In this report, dexmedetomidine‐based general anesthesia, in combination with a thoracic epidural for laparoscopic cholecystectomy in a patient with Steinert disease, is presented. An Aintree intubation catheter with the guidance of a fiberoptic bronchoscope was used for intubation to avoid laryngoscopy. Prolonged anesthetic effects of propofol were reversed, and recovery from anesthesia was accelerated using an intravenous infusion of theophylline. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
8. Stability-indicating RP-HPLC method for simultaneous estimation of levosalbutamol sulfate and theophylline in combined dosage form
- Author
-
Sagar Suman Panda, Bera Venkata Varaha Ravi Kumar, and Ganeswar Mohanta
- Subjects
Levosalbutamol ,Teofilina ,Indicador de estabilidade ,RP-Cromatografia líquida de alto desempenho ,Xarope ,Pharmacy and materia medica ,RS1-441 - Abstract
A novel, simple, accurate and precise RP-HPLC method for simultaneous determination of levosalbutamol sulfate and theophylline has been developed and validated. Separation was achieved on a Phenomenex; C18 column (250 mm × 4.6 mm i.d., 5 µm) using methanol: 10 mM TBAHS(tetrabutyl ammonium hydrogen sulfate) (50:50, v/v) as mobile phase at flow rate of 1.0 mL.min-1. The UV detection wavelength was 274 nm. The linearity is obeyed over a concentration range of 0.5-150 µg.mL-1 with correlation coefficient of 0.999 for both the drugs. The proposed method was validated by determining accuracy, precision, stability and system suitability parameters. The method was found to be robust. Specificity of the method was determined by subjecting the drugs to various stress conditions like acid, alkali, oxidation, thermal and photolytic degradation. The method was used successfully for the simultaneous determination of levosalbutamol sulfate and theophylline in syrup dosage form.
- Published
- 2013
- Full Text
- View/download PDF
9. Efecto del adyuvante vacunal AFCo1 intranasal sobre la concentración plasmática de teofilina en ratas Effect of intranasal vaccine adjuvant AFCo1 on plasma concentration of theophylline in rats
- Author
-
Alexander Batista Duharte, Onel Fong Lores, José Carlos Rodríguez Tito, Edgar Puente Zapata, and Oliver Pérez Martin
- Subjects
AFCo1 ,adyuvante ,rata Sprague-Dawley ,citocromo P450 ,teofilina ,toxicidad ,adjuvant ,Sprague-Dawley rat ,P450 cytochrome ,theophylline ,toxicity ,Medicine (General) ,R5-920 ,Internal medicine ,RC31-1245 - Abstract
En este estudio se evaluó el efecto del adyuvante Finlay cocleato 1 (AFCo1), aplicado 4 veces por vía intranasal en 2 niveles de dosis (50 µg y 100 µg) sobre la concentración plasmática de teofilina, administrada a las 24 horas de la última aplicación (5 mg/kg, por vía intraperitoneal) en ratas Sprague-Dawley. Se empleó como control positivo de inflamación la aplicación de 2 dosis por vía subcutánea de adyuvante completo de Freund (ACF). Las ratas que recibieron AFCo1 no mostraron cambios significativos en la concentración sérica de teofilina; mientras que las tratadas con ACF desarrollaron inflamación local asociadas a signos de toxicidad a la teofilina y elevación de las cifras de inmunoglobulina G específica, de las concentraciones plasmáticas y el tiempo de vida media de teofilina en suero, en comparación con los grupos restantes. Estos resultados indican que la inmunoestimulación inducida por AFCo1 intranasal no incrementa los parámetros farmacocinéticos ni la toxicidad de la teofilina en el modelo empleado.The effect of the adjuvant Finlay cochleate1 (AFCo1), applied intranasally 4 times in 2 dose levels (50 µg and 100 µg) on plasma concentration of theophylline administered 24 hours after the last application (5 mg/kg intraperitoneally) in Sprague-Dawley rats was evaluated in this study. Application subcutaneously of 2 doses of Freund's complete adjuvant (FCA) was used as positive control of inflammation. Rats receiving AFCo1 had no significant changes in serum theophylline concentration, while those treated with FCA developed local inflammation associated with signs of theophylline toxicity and increased specific G immunoglobulin, plasma concentrations and serum theophylline half-life as compared with the remaining groups. These results show that intranasal AFCo1-induced immunostimulation does not increase pharmacokinetic parameters and theophylline toxicity in the model used.
- Published
- 2012
10. In vitro study on the interaction of ketotifen fumarate with anhydrous theophylline
- Author
-
Mohammed Aktar Sayeed, Razibul Habib, Mominur Rahman, Hasan Al Banna, and Sohel Rana
- Subjects
Constante de estabilidade ,Método de Job ,Método de Ardon ,Cetotifeno ,Teofilina ,Stability constant ,Job's method ,Ardon's method ,Ketotifen ,Theophylline ,Pharmacy and materia medica ,RS1-441 - Abstract
The purpose of the present study was to investigate the interaction between ketotifen fumarate and anhydrous theophylline in aqueous media of various pH (1.2 and 6.8). Using Job's continuous-variation analysis and Ardon's spectrophotomeric measurement methods, the values of the stability constants of theophylline with ketotifen were determined at a fixed temperature (37 ºC) at various pH. The stability constants, ranging between 5.66 and 9.92, were derived from Ardon's plot, indicating that comparatively stable complexes had formed as a result of an interaction between the drugs. However, following the interaction of theophylline with ketotifen, stability constants were O objetivo do presente estudo foi investigar a interação entre o fumarato de cetotifeno e a teofilina anidra em meios aquosos com vários pH (1,2 e 6,8). Utilizando a análise da variação contínua de Job e os métodos de medida espectrofotométrica de Ardon, os valores das constantes de estabilidade da teofilina com o cetotifeno foram determinados em temperatura fixa (37 oC) em vários pH. As constantes de estabilidade, variando entre 5,66 e 9,92 derivaram-se a partir do delineamento de Ardon, indicando, comparativamente, que complexos estáveis se formaram como resultado da interação entre os fármacos. Entretanto, seguindo a interação da teofilina com o cetotifeno, as constantes de estabilidade foram
- Published
- 2012
- Full Text
- View/download PDF
11. Biodisponibilidad relativa de un preparado de Teofilina expendido en el mercado nacional
- Author
-
H. Serrat., M. Andresen., G. Prat., M. Ruiz, and P. Leiva
- Subjects
teofilina ,disponibilidad biolã³gica ,Medicine - Abstract
Sin resumen
- Published
- 2017
12. Desarrollo y validación de un método analítico (HPLC RP) para la determinación de teofilina en plasma
- Author
-
Luisa Fernanda Ponce D´léon, Jaime H. Rojas, and Alfredo Oviedo A.
- Subjects
teofilina ,cafeína ,HPLC ,C18 ,niveles sanguíneos ,detección UV ,biodisponibilidad ,bioequivalencia ,Chemistry ,QD1-999 - Abstract
Theophylline is a drug widely known for treating asthma and sorne other chronic respiratory diseases. At present time,the blood levels of drugs can be related with eficacy and side effects. There are around 10 drug products ofprogrammedrelease theophyIline forms, commercially available in Colombia. Most of the problems found in the utilization are caused by the non advisable interchange of theophyIline drug products, without any bioequivalency data for them. This study proposes a specific and validated analytical methodology for theophylline in biological fluid s including blood, which is useful for bioavailability and bioequivalencystudies, rutinary monitoring of theophylline blood levels and in forensic chemistry. This metodology has the advantage. touse a mobile phase les s contaminant and cheaper than others previously used. Besides, it makes easier the cleaning of the equipment and extend the useful life of the column. The chromatographic separation system by HPLC-RP, with spectrophotometric detection at 266 nm, ineludes an octadecylsilane C-18 column, and methanol/water as mobile phase.
- Published
- 2011
13. Termodinámica del proceso de adsorción in vitro de teofilina en carbón activado a partir de fluido gástrico simulado.
- Author
-
Rey-Mafull, C. Carlos A., César-Llópiz, C. Julio, Hotza, C. Dachamir, and García-Gallardo, Raquel
- Subjects
- *
THEOPHYLLINE , *ACTIVATED carbon , *GASTRIC juice , *THERMODYNAMICS , *ADSORPTION isotherms , *CHEMISORPTION - Abstract
The in vitro adsorption of theophylline onto seven selected materials (NB, NE, BDH, Ch3J, Merck, Panreac, ML) was studied in simulated gastric fluid at pH 1.2 and 4 h by using shaker water bath within a temperature range 300 to 317 K in batch experiments. The experimental adsorption was fitted by eight isotherms models: Langmuir Type I and II, DR, Halsey, Freundlich, Harkins-Jura, Temkin and BET. Materials were characterized by pHzpc, and N2 77 K. The best linear (R² = 098) and non linear (R² = 0.95, RAMSE=43) fittings of isotherms models were obtained with Langnuir TI which assumes monolayer adsorption and specific interactions. The theophylline adsorption was controlled by chemisorptions and exothermically process (ΔH = -36.81-88.70 kJ/mol) with maximal capacity, q m (316-587 mg/g). The ΔG < 0 indicate the spontaneous character and more favourable at lower temperature. ΔS < 0 suggests a decrease in the order of the adsorbed system with losses of freedom willingly. [ABSTRACT FROM AUTHOR]
- Published
- 2016
14. The usage of sustained-action theophyline in the intercrisis treatment of bronchial asthma.
- Author
-
Yaquelín Martínez Chavez., Arlette Linares Borges., Pedro Miguel Milián Vázquez., Lisett Jiménez Fernández., Maira Quirós Enríquez., and Higinio Alemán Aguiar
- Subjects
asma ,teofilina ,estado asmático ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Fundaments: Bronchial Asthma is a chronic inflammatory disease of the air ways. Theophylline is recommended in its treatment because of its probable anti-inflamatory effect. Due to this reason, the clinical effect of sustained action theophylline (TEOCEN 200mg) is assessed in the intercrisis of Bronchial Asthma. Method : 40 moderate and severe asthmatic patients received treatment with a 9 mg/kg/day dose every 12 hours (q.12), at the outpatient consultation of the University Hospital Celestino Hdez¨ of Villa Clara, from September 2002 to June 2003. Treatment lasted a month, period in which had 5 visits to the doctor. The variables under study in each visit were: attendance to the emergency department, use of salbutamol spray and objective measurement of lung function as well as adverse effects and response to treament. Wilconxon, Cochron Q and Mc. Nemor´s non-parametric tests were used in this study. Significant difference was considered as p< 0, 05, highly significant difference as p< 0,01. Results : The use of salbutamol spray and the need to go to the emergency department diminished significantly meanwhile the peak expiratory flux, the forced expiratory volume in one second, the maximum expiratory medium flux and the forced expiratory volume in one second post salbutamol application increased significantly. There was a low incidence of adverse effects. Conclusion : The formula was useful and is recommended in the control of the symptoms of moderate and severe asthmatic patients in the intercrisis period.
- Published
- 2004
15. Prueba comparativa de uniformidad de contenido en tabletas de teofilina (150 mg/tab) de dos casas farmacéuticas en Costa Rica
- Author
-
Esteban Pérez-López, Kevin Morales-Alfaro, Alfonso Rojas-Hernández, and Anderson Vargas-Vargas
- Subjects
Teofilina ,uniformidad de contenido ,principio activo ,tabletas ,absorbancia ,espectroscopía ,Technology - Abstract
Dada la importancia del medicamento denominado teofilina para su uso en pacientes con problemas de asma y su alto consumo en Costa Rica, se eligió el producto en tabletas de 150 mg de teofilina de una casa farmacéutica que lo produce y distribuye en forma genérica, junto con el que fabrica la Caja Costarricense de Seguro Social (CCSS) en la misma dosis. Se realizó el estudio comparativo de la prueba de uniformidad de contenido para las tabletas de teofilina de 150 mg de la casa farmacéutica LISAN y las fabricadas por la CCSS. La prueba de uniformidad de contenido analíticamente se fundamentó en la absorción y cuantificación del ingrediente activo teofilina a 272 nm para 10 muestras de cada casa farmacéutica, mediante el uso de un espectrofotómetro UV/Vis, empleando como disolvente agua destilada. Se probó un método selectivo, exacto y preciso y se obtuvo como resultado que todas las dosis ensayadas para cada fabricante se encuentran en el rango de 100% a 110%, con respecto a lo etiquetado sobre el principio activo en las tabletas y con un desvío relativo no mayor al 2,5%, cumpliendo holgadamente con lo establecido por la Farmacopea de Estados Unidos para la prueba de uniformidad de contenido.
- Published
- 2014
- Full Text
- View/download PDF
16. Anestesia geral sem opioide e recuperação induzida da anestesia em paciente com distrofia miotônica tipo-1: relato de caso
- Author
-
Gurbuz,Hande and Saracoglu,Kemal Tolga
- Subjects
Despertar prolongado da anestesia ,Dexmedetomidina ,Cateter para troca de tubo traqueal ,Distrofia miotônica ,Teofilina ,Theophylline ,Delayed emergence from anesthesia ,Período de recuperação da anestesia ,Myotonic dystrophy ,Exchange catheter ,Anesthesia recovery period ,Dexmedetomidine - Abstract
Myotonic dystrophy type-1 (Steinert disease) is an autosomal dominant, progressive multisystem disease in which myotonic crisis can be triggered by several factors including pain, emotional stress, hypothermia, shivering, and mechanical or electrical stimulation. In this report, dexmedetomidine-based general anesthesia, in combination with a thoracic epidural for laparoscopic cholecystectomy in a patient with Steinert disease, is presented. An Aintree intubation catheter with the guidance of a fiberoptic bronchoscope was used for intubation to avoid laryngoscopy. Prolonged anesthetic effects of propofol were reversed, and recovery from anesthesia was accelerated using an intravenous infusion of theophylline. Resumo A Distrofia Miotônica (DM) tipo-1 (Doença de Steinert) é uma doença multissistêmica progressiva autossômica dominante em que a crise miotônica pode ser desencadeada por vários fatores, incluindo dor, estresse emocional, hipotermia, tremores e estímulo mecânico ou elétrico. O presente relato descreve anestesia geral realizada com dexmedetomidina em combinação com peridural torácica para colecistectomia laparoscópica em paciente com Doença de Steinert. Para evitar laringoscopia, a intubação traqueal foi realizada utilizando cateter de intubação Aintree guiado por broncofibroscopia óptica. Os efeitos anestésicos prolongados do propofol foram revertidos e a recuperação anestésica foi acelerada pelo uso de infusão intravenosa de teofilina.
- Published
- 2021
17. Aspectos farmacológicos de la terapéutica del paciente asmático
- Author
-
Alicia Zapata Martínez and Germán Vergel Rivera
- Subjects
ASMA ,CALIDAD DE VIDA ALBUTEROL ,TEOFILINA ,N-ISOPROPILATROPINA ,CROMOGLICATO DISODICO ,GLUCOCORTICOIDES ,ASTHMA ,QUALITY OF LIFE ,ALBUTEROL ,THEOPHYLLINE ,N-ISOPROPYLATROPINE ,DISODIUM CROMOGLYCATE ,GLUCOCORTICOIDS ,Medicine (General) ,R5-920 - Abstract
El asma bronquial es un importante problema de salud en la atención primaria. Se sabe que un tratamiento correcto de la enfermedad contribuye a mejorar la calidad de vida de estos pacientes. Se revisan los principales aspectos farmacológicos (acciones, indicaciones, efectos adversos, vía de administración y dosis de los 2 grupos de medicamentos más empleados en la terapéutica de la enfermedad que son: los broncodilatadores (salbutamol, teofilina, bromuro de ipratropio) y los antiinflamatorios (cromoglicato de sodio y glucocorticoides)Bronchial asthma is an important health problem in primary health care. It is known that an adequate treatment of the disease helps to improve the quality of life of these patients. The main pharmacological aspects (actions, indications, side effects, administration and dosage) of the 2 most used groups of drugs in the therapeutics of the disease that are: the bronchodilators (salbutamol, theophylline, and ipratropium bromide), and the antiinflammatory drugs (disodium cromoglycate and glucocorticoids) are reviewed.
- Published
- 1998
18. Xantinas en el asma: ¿ascenso o descenso?
- Author
-
Rogelio Alvarez Sintes, Roberto Alvarez Sintes, Guillermo Díaz Alonso, and Hubert Rivero Martínez
- Subjects
ASMA ,TEOFILINA ,Medicine (General) ,R5-920 - Abstract
La teofilina ha sido utilizada como broncodilatador en el tratamiento del asma en su forma aguda y crónica desde hace más de 50 años. A partir de 1990 el uso de las xantinas en el asma se discute cada vez más. En 1995 persisten las controversias, pero la balanza se desplaza cada vez más hacia los broncodilatadores simpaticomiméticos, pasando a ocupar ésta la tercera o cuarta opción en los esquemas terapéuticos.1-4 Se revisa la literatura médica al respecto y se exponen las razones para su mayor o menor uso.
- Published
- 1995
19. Theophylline for Attenuating Ticagrelor-Related Dyspnea
- Author
-
Marcelo, Sanmartin-Fernandez and Jose Luis, Zamorano
- Subjects
Síndrome Coronariana Aguda ,Ticagrelor ,Dyspnea ,Teofilina ,Theophylline ,Research Letter ,Humans ,Carta Científica ,Acute Coronary Syndrome ,Platelet Aggregation Inhibitors - Published
- 2020
20. Evaluación de las subpoblaciones de linfocitos T en pacientes tuberculosos empleand la modulación con teofilina T lymphocyte subsets evaluation in patients with pulmonary tuberculosis using theophylline modulation
- Author
-
Diana Dlugovitzky, K. Huber, G. Welker, and O. Molteni
- Subjects
Tuberculosis ,Subpoblaciones de linfocitos T ,Teofilina ,Arctic medicine. Tropical medicine ,RC955-962 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Se evaluaron las poblaciones y subpoblaciones linfocitarias en pacientes con tuberculosis pulmonar antes y durante la terapia relacionando estos valores con la incidencia y evolución de la enfermedad. Pacientes en sus diversas manifestaciones clínicas, vírgenes de tratamiento, se estudiaron por baciloscopía (BAAR), radiología, i.d.r. Mantoux y análisis complementarios. Se cuantificaron mediante la prueba de Rosetas espontáneas (RE) linfocitos T totales y activos (RE a 4ºC y 37ºC), T colaboradores (RE Teofilina Resistentes: RETR) y supresores (RE Teofilina Sensibles: RETS). Los exámenes se repitieron en los mismos sujetos iniciado el tratamiento y en testigos sanos (TS). Se demostró en los pacientes en todas sus formas clínicas un descenso significativo en los valores relativos y absolutos de células T y en la relación RETR/RETS (menor de 1). Existe asociación entre la forma clínica y el número de linfocitos T colaboradores. Los pacientes en tratamiento con evolución favorable, evidenciaron un incremento significativo en los linfocitos T totales, activos, colaboradores y en la relación RETR/RETS. Los enfermos con baciloscopía altamente positiva presentaron i.d.r. Mantoux baja o negativa y marcado descenso de células inmunocompetentes. Se comprobó asociación entre estas tres variables, lo mismo que entre el estado nutricional y la predisposición a contraer la enfermedad.T cells and T cells subsets in peripheral blood of patients with different forms of pulmonary tuberculosis were evaluated to explain some aspects of the immunocompromised state of these subjects. Diagnosis was made by baciloscopy (BAAR), chest roentgenography i.d.r Mantoux, and other clinical analysis. Spontaneous E-Rosette test (RE) was used to quantify Total (RET 4ºC) and Active T cells (REA 37ºC) and the same test after incubation with Theophilline (The) for helper cells (The-re-sistant cells: RETR) and suppressor cells (The-sensitive cells: RETS). Patients were followed for at least 4 months after therapy. The data demonstrate a significant decrease of relative and absolute numbers of Total T-cells and a diminished T helper/T suppressor subset ratio (RETR/RETS) which dropped to less than 1 in untreated patients. Treated patients with a favourable evolution showed a restoration of Total active and helper T cells. RETR/RETS ratio was also significantly increased. In patients with highly positive BAAR, low on negative i.d.r Mantoux, a decreased level of immunocompetent cells was observed. The 3 aspects were associated. Nutritional condition of the patients wal also associated with the predisposition to acquire this disease.
- Published
- 1991
- Full Text
- View/download PDF
21. Avaliação da Goma Guar no desenvolvimento de comprimidos matriciais de liberação controlada de teofilina
- Author
-
Edilene Gadelha de Oliveira, Rosana de Sousa Campos, Anaiara Silva Machado, Juliana Fernandes Pereira, and Tamara Gonçalves de Araújo
- Subjects
Goma Guar ,teofilina ,comprimidos ,liberação controlada ,Chemical technology ,TP1-1185 - Abstract
Resumo O objetivo desse estudo foi formular e avaliar comprimidos de liberação controlada. Comprimidos de liberação controlada de teofilina foram preparadas pelo método de compressão direta usando dois polímeros como, o HPMC K 100M (polímero hidrofílico) e a Goma Guar (Polímero natural), isolado ou em mistura (GG:HPMC 3:1) e GG:HPMC 1:3). Os comprimidos foram caracterizados através do peso médio, diâmetro, altura, dureza, friabilidade. Todos os resultados estiveram em conformidade com os limites aceitáveis. O ensaio de intumescimento foi realizado em água destilada durante 4 horas, sendo determinado pela diferença de peso do comprimido seco e intumescido. O ensaio de dissolução foi realizado em água destilada (900 mL, 37 ± 0,5ºC, 50 rpm, aparato II) durante 8 horas. Os resultados demonstraram que a Goma guar isolada não possui capacidade de retardar a liberação da teofilina por 8 horas. Comprimidos matriciais contendo GG:HPMC (3:1) apresentaram um melhor controle de liberação da teofilina.
- Published
- 2015
- Full Text
- View/download PDF
22. Teoilina, una nueva mirada a un medicamento antiguo.
- Author
-
Morfín Maciel, Blanca María and Castillo Morfín, Blanca María
- Subjects
- *
THEOPHYLLINE , *ANTI-inflammatory agents , *HISTONE deacetylase , *DRUG resistance , *OBSTRUCTIVE lung diseases , *DRUG efficacy , *IMMUNOREGULATION , *PHOSPHODIESTERASES - Abstract
Objectives: To emphasize the safety and efficacy of theophylline in chronic inflammatory respiratory diseases. To mention its immunomodulatory effects. Data sources: PubMed search using the keywords: theophylline, histone deacetylase, antiinflammatory, asthma, chronic obstructive pulmonary disease (COPD), corticoresistance. Results: Theophylline is a methylxantine, that inhibits phosphodiesterase (PDE), induces histone deacetylase and antagonizes adenosine. Its main effect is to relax airway smooth muscle. The immunomodulatory effects of theophylline are obtained at low plasma concentrations (less than 10 mg/L). The combination of inhaled corticoesteroids and theophylline exerts a synergistic antiinflammatory effect that improves asthma control and reduces COPD exacerbations. Histones are a group of transcriptional cofactors involved in chromatin remodeling. Histone deacetylases (HDACs) suppress inflammatory gene expression. In patients with COPD and severe asthma there is a reduction in HDAC-2 secondary to the increased oxidative and nitrative stress. HDAC-2 is required by corticosteroids to switch off activated inflammatory genes, then its reduction favors corticosteroid resistance. Theophylline via HDAC-2 induction and PDE inhibition, suppresses inflammatory gene expression, and inhibits free oxygen radicals production. Conclusions: Theophylline at low plasma concentrations exerts antiinflammatory effects, restoring corticosteroid sensitivity in COPD and severe asthma. [ABSTRACT FROM AUTHOR]
- Published
- 2010
23. Broncodilatadores en el tratamiento del asma crónica
- Author
-
Rogelio Alvarez Sintes, Roberto Alvarez Sintes, and Manuel Alvarez Castro
- Subjects
ASMA ,SIMPATICOMIMETICOS ,TEOFILINA ,PARASIMPATOLITICOS ,Medicine (General) ,R5-920 - Abstract
Se realiza una revisión de la literatura médica al respecto y se señalan las pautas actuales del tratamiento broncodilatador intercrítico del paciente asmático, con el objetivo de facilitar al personal de atención ambulatoria los elementos necesarios en la atención de nuestros pacientes.
- Published
- 1995
24. Validación de un método analítico por HPLC para la cuantificación del principio activo en tabletas de Controfilina-200.
- Author
-
Contreras Roura, Jiovanna, Jardínes Leyva, Yunaysi, Fonseca, Magdalena, and Águila, Belinda
- Published
- 2005
25. Síntese de aerogéis de carragenano para aplicação em sistemas de libertação controlada de compostos com interesse na indústria farmacêutica
- Author
-
Agostinho, Daniela Alexandra Semedo, Ventura, Márcia, Nunes, Ana, and Fonseca, Isabel
- Subjects
Tetraciclina ,Teofilina ,Engenharia e Tecnologia::Engenharia Química [Domínio/Área Científica] ,κ-carragenano ,Líquidos iónicos ,Aerogéis ,Libertação de fármacos - Abstract
A recente procura por polímeros naturais devido às suas características favoráveis para a utilização em diversas áreas como a indústria farmacêutica, tem vindo a promover a tentativa de encontrar métodos mais eficientes, limpos e, portanto, mais sustentáveis para a sua extração. Os líquidos iónicos têm sido propostos como solventes alternativos na extração e na dissolução de polissacarídeos. Assim sendo, neste trabalho, a eficiência de alguns LIs para extrair carragenano foi averiguado com o objetivo destes poderem vir a substituir os solventes orgânicos utilizados nos processos de extração tradicionais, que são mais tóxicos e voláteis que os LIs. O carragenano é um polissacarídeo, extraído a partir de algas vermelhas, com características muito favoráveis para aplicações farmacêuticas e alimentares. Neste trabalho extraiu-se carragenano a partir da alga Chondrus crispus, utilizando soluções alcalinas (extração tradicional), H2O e LIs em diferentes concentrações. Os géis de κ-car, foram sintetizados com adição de sais e por dissolução em LIs, posteriormente foram secos por scCO2. Diversas técnicas de caracterização foram utilizadas para estudar o carragenano extraído (FTIR-ATR e DSC), bem como os aerogéis de κ-car sintetizados (FTIR-ATR, TGA, DSC, ASAP e SEM). A estrutura porosa dos aerogéis de polissacarídeos detém características apelativas à aplicação na indústria farmacêutica, como sistemas libertação controlada de fármacos, e por isso neste trabalho estudou-se a libertação de dois fármacos a partir de aerogéis de κ-car. A libertação da teofilina e da tetraciclina foi estudada a um pH de 7,4 e a 37ºC de modo a simular uma libertação no intestino. A tetraciclina demonstrou ter maior afinidade que a teofilina com os aerogéis de κ-car sintetizados, uma vez que a libertação do fármaco foi mais prolongada.
- Published
- 2018
26. Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
- Author
-
María Gabriela Echeverría, Oscar Ricardo Pardini, Nora J. François, Marta Edith Daraio, María V. Debandi, and Javier Ignacio Amalvy
- Subjects
Materials science ,polyurethanes ,stimuli-sensitive polymers ,lcsh:Chemical technology ,Methacrylate ,drug delivery systems ,swelling ,chemistry.chemical_compound ,Teofilina ,Polymer chemistry ,medicine ,Chemical Engineering (miscellaneous) ,lcsh:TP1-1185 ,Theophylline ,Fourier transform infrared spectroscopy ,Polyurethane ,chemistry.chemical_classification ,Poliuretanos ,Organic Chemistry ,Swelling capacity ,Ciencias Químicas ,Polymer ,poliuretanos, sistemas de liberación de medicamentos, teofilina ,theophylline ,Ingeniería Química ,polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline ,Sistemas de Liberación de Medicamentos ,chemistry ,Drug delivery ,Swelling ,medicine.symptom ,Nuclear chemistry ,medicine.drug - Abstract
A pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film‑forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release., Facultad de Ingeniería
- Published
- 2015
27. Stability-indicating RP-HPLC method for simultaneous estimation of levosalbutamol sulfate and theophylline in combined dosage form
- Author
-
Bera V. V. Ravi Kumar, Sagar Suman Panda, and Ganeswar Mohanta
- Subjects
lcsh:RS1-441 ,Xarope ,Levosalbutamol^i2^sdetermina ,Teofilina^i2^sdetermina ,Dosage form ,lcsh:Pharmacy and materia medica ,chemistry.chemical_compound ,Teofilina ,Theophylline ,Stability indicating ,medicine ,General Pharmacology, Toxicology and Pharmaceutics ,Sulfate ,RP-Cromatografia líquida de alto desempenho ,Chromatography ,Levosalbutamol ,Stability-indicating ,Indicador de estabilidade ,Theophylline^i1^sdeterminat ,RP-High performance liquid chromatography^i1^squalitative analysis Sy ,Levosalbutamol^i1^sdeterminat ,chemistry ,RP-High performance liquid chromatography ,Xarope^i2^sanálise qualitat ,RP-High performance liquid chromatography^i1^squalitative analy ,medicine.drug - Abstract
A novel, simple, accurate and precise RP-HPLC method for simultaneous determination of levosalbutamol sulfate and theophylline has been developed and validated. Separation was achieved on a Phenomenex; C18 column (250 mm × 4.6 mm i.d., 5 µm) using methanol: 10 mM TBAHS(tetrabutyl ammonium hydrogen sulfate) (50:50, v/v) as mobile phase at flow rate of 1.0 mL.min-1. The UV detection wavelength was 274 nm. The linearity is obeyed over a concentration range of 0.5-150 µg.mL-1 with correlation coefficient of 0.999 for both the drugs. The proposed method was validated by determining accuracy, precision, stability and system suitability parameters. The method was found to be robust. Specificity of the method was determined by subjecting the drugs to various stress conditions like acid, alkali, oxidation, thermal and photolytic degradation. The method was used successfully for the simultaneous determination of levosalbutamol sulfate and theophylline in syrup dosage form. Desenvolveu-se e validou-se método de RP-HPLC novo, simples, exato e preciso de determinação simultânea do sulfato de levossalbutamol e teofilina.. A separação foi efetuada em uma coluna Phenomenex; C18 (250 mm x 4,6 mm d.i., 5 µm) utilizando metanol: TBAHS (hidrogenossulfato de tetrabutilamônio) 10 mM (50:50, v/v) como fase móvel, com fluxo de 1,0 mL.min-1. O comprimento de onda de detecção no UV foi 274 nm. Observou-se linearidade na faixa de concentração de 0,5-150 µg mL-1, com coeficiente de correlação de 0,999 para ambos os fármacos. O método proposto foi validado determinando-se exatidão, precisão, estabilidade e parâmetros de adequação do sistema. O método mostrou-se robusto. A especificidade do método foi determinada submetendo os fármacos a várias condições de estresse, como ácido, álcali, oxidação, degradação térmica e fotolítica. O método foi usado com sucesso para a determinação simultânea do sulfato de levossalbutamol e teofilina na forma de xarope.
- Published
- 2013
28. [Opioid-free general anesthesia and induced recovery from anesthesia in a patient with myotonic dystrophy type-1: a case report].
- Author
-
Gurbuz H and Saracoglu KT
- Subjects
- Analgesics, Opioid, Anesthesia Recovery Period, Bronchoscopes, Female, Humans, Hypnotics and Sedatives, Intubation, Intratracheal methods, Middle Aged, Propofol, Theophylline administration & dosage, Analgesics, Non-Narcotic, Anesthesia, Epidural methods, Anesthesia, General methods, Cholecystectomy, Laparoscopic methods, Dexmedetomidine, Myotonic Dystrophy complications
- Abstract
Myotonic dystrophy type-1 (Steinert disease) is an autosomal dominant, progressive multisystem disease in which myotonic crisis can be triggered by several factors including pain, emotional stress, hypothermia, shivering, and mechanical or electrical stimulation. In this report, dexmedetomidine-based general anesthesia, in combination with a thoracic epidural for laparoscopic cholecystectomy in a patient with Steinert disease, is presented. An Aintree intubation catheter with the guidance of a fiberoptic bronchoscope was used for intubation to avoid laryngoscopy. Prolonged anesthetic effects of propofol were reversed, and recovery from anesthesia was accelerated using an intravenous infusion of theophylline., (Copyright © 2020 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
29. Efectos de la teofilina sobre el tamaño celular y celularidad en ratones BALB/C durante la organogénesis
- Author
-
Eulalia Fernández-Vallín Cárdenas, Karelia Montané Jaime, José Ramón Molina García, and Mayra Alvarez Corredera
- Subjects
TEOFILINA ,ADN ,PROTEINAS ,CELULAS ,DESARROLLO FETAL ,RATONES CONSANGUINEOS BALB/C ,INTRODUCCION ,THEOPHYLLINE ,DNA ,PROTEINS ,CELLS ,FETAL DEVELOPMENT ,MICE, INBRED BALB/C ,Medicine (General) ,R5-920 - Abstract
Se explora el efecto de la administración de 7 mg/kg de peso corporal diarios de teofilina por vía intraperitoneal entre los días 8 y 14 de la preñez en 28 ratones BALB/C sobre el contenido de DNA y proteínas de los fetos al nacer y los estimadores del tamaño y número de células. Los resultados fueron comparados con los de un grupo control de 36 animales. Los resultados indicaron que la teofilina no afectó significativamente el contenido de DNA y proteínas, ni el tamaño y número de células de los fetos.The effects of the administration of 7 mg/kg of body weight of daily intraperitoneal theophylline, is explored between days 8 and 14 of pregnancy in 28 BALB/C mice, on the DNA and protein contents of the fetuses at birth, and the estimators of size and cell amount. The results were compared with those from a 36 animals control group. Those results indicated that theophylline didn't significantly affect either the DNA and protein contents, or the size and cell amount of the fetuses.
- Published
- 1996
30. Haemophilus influenzae induces steroid-resistant inflammatory responses in COPD
- Author
-
Amanda Iglesias, Alvar Agusti, Andreas Jahn, Borja G. Cosío, Hanaa Shafiek, Xavier Busquets, and Universitat de Barcelona
- Subjects
Male ,teofilina ,glucocorticoides ,Colonization ,Nuclear Factor-κB ,medicine.medical_treatment ,dexametasona ,humanos ,Pharmacology ,broncodilatadores ,medicine.disease_cause ,Dexamethasone ,Haemophilus influenzae ,Cromatina ,Pulmonary Disease, Chronic Obstructive ,infecciones del tracto respiratorio ,macrófagos ,Respiratory Tract Infections ,Malalties pulmonars obstructives cròniques ,mediana edad ,anciano ,U937 cell ,Smoking ,NF-kappa B ,línea celular ,Middle Aged ,adulto ,Inflamació ,Chromatin ,Bronchodilator Agents ,Cytokine ,Cytokines ,Female ,medicine.symptom ,Research Article ,medicine.drug ,Pulmonary and Respiratory Medicine ,Adult ,Haemophilus Infections ,Blotting, Western ,estudios de casos y controles ,Inflammation ,In Vitro Techniques ,Histone Deacetylases ,Cell Line ,COPD exacerbation ,Theophylline ,inflamación ,Macrophages, Alveolar ,medicine ,Nuclear Factor-kappa B ,Humans ,Histone deacetylase ,Chronic obstructive pulmonary diseases ,Glucocorticoides ,Glucocorticoids ,Aged ,histona desacetilasas ,business.industry ,Macrophages ,hábito de fumar ,NFKB1 ,Case-Control Studies ,Immunology ,infecciones por Haemophilus ,citocinas ,business - Abstract
Background: Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder partially resistant to glucocorticoids. A reduced histone deacetylase (HDAC) activity has been proposed to explain this resistance. Haemophilus influenzae frequently colonizes the airways of COPD patients, where it enhances inflammation. The effects of Haemophilus influenzae on HDAC activity have not been investigated before. Methods: The effects of the presence or absence of Haemophilus influenzae ex-vivo and in vitro were studied. To this end, we determined: (1) cytokine release in alveolar macrophages (AM) from 7 patients with COPD, 5 healthy smokers, 6 healthy non-smokers and (2) HDAC activity, nuclear factor kappa B (NF-kappa B) activation in a macrophage-like cell line (PMA-transformed U937 cells) co-cultured with epithelial cells. Experiments were repeated with dexamethasone (1 mu M) and/or the HDAC enhancer theophylline (10 mu M). Results: Haemophilus influenzae induced a steroid-resistant inflammatory response in AM from COPD and controls and decreased HDAC activity, activated NF-kappa B and induced the secretion of several cytokines (IL-6, IL-8, IL-1 beta, IL-10 and TNF-alpha) (p < 0.001 for all comparisons) in the macrophage-like cell line. Dexamethasone reduced NF-kappa B activation but it did not modify HDAC activity. The addition of theophylline to dexamethasone increased HDAC activity and suppressed cytokine release completely, without modifying NF-kappa B activation. Conclusions: These results indicate that Haemophilus influenzae reduces HDAC activity and induces a NF-kappa B mediated inflammatory response that is only partially suppressed by glucocorticoids irrespective of having COPD. Yet, the latter can be fully restored by targeting HDAC activity., This project was supported by a grant from the Institute of Health Carlos III (FIS 04/2146), Ciberes and ABEMAR. Authors thank Dr Catalina Crespi for her assistance in the Cytometric Bead Assay, and Dr Antonio Oliver for his generous gift of NTHi strain.; Supported by FIS 04/2146, Ciberes and ABEMAR.
- Published
- 2015
31. Avaliação da Goma Guar no desenvolvimento de comprimidos matriciais de liberação controlada de teofilina
- Author
-
Oliveira, Edilene Gadelha de, Campos, Rosana de Sousa, Machado, Anaiara Silva, Pereira, Juliana Fernandes, and Araújo, Tamara Gonçalves de
- Subjects
teofilina ,liberação controlada ,tablets ,comprimidos ,Goma Guar ,theophylline ,controlled release ,Guar Gum - Abstract
Resumo O objetivo desse estudo foi formular e avaliar comprimidos de liberação controlada. Comprimidos de liberação controlada de teofilina foram preparadas pelo método de compressão direta usando dois polímeros como, o HPMC K 100M (polímero hidrofílico) e a Goma Guar (Polímero natural), isolado ou em mistura (GG:HPMC 3:1) e GG:HPMC 1:3). Os comprimidos foram caracterizados através do peso médio, diâmetro, altura, dureza, friabilidade. Todos os resultados estiveram em conformidade com os limites aceitáveis. O ensaio de intumescimento foi realizado em água destilada durante 4 horas, sendo determinado pela diferença de peso do comprimido seco e intumescido. O ensaio de dissolução foi realizado em água destilada (900 mL, 37 ± 0,5ºC, 50 rpm, aparato II) durante 8 horas. Os resultados demonstraram que a Goma guar isolada não possui capacidade de retardar a liberação da teofilina por 8 horas. Comprimidos matriciais contendo GG:HPMC (3:1) apresentaram um melhor controle de liberação da teofilina. Abstract Guar gum (GG) has been widely used in drug delivery systems due to its low cost and nontoxicity. Theophylline controlled release tablets were prepared by directly compressed method using two polymers such as HPMC K 100M (hydrophilic polymer) and Guar Gum (natural polymer), isolated or in mixture (GG:HPMC 3:1 and GG:HPMC 1:3). The formulated tablets were evaluated for: weight variation, diameter, height, hardness and friability. All the parameters were within the acceptable limits. The swelling test was performed in distilled water for 4 hours, it was determined by the difference in weight of the dry and swollen tablet. The dissolution test was performed in distilled water (900 mL, 37 ± 0.5ºC, 50 rpm, apparatus II) for 8 hours. The results showed that guar gum alone could not control the theophylline release effectively for 8 hours. Matrix tablet prepared from GG: HPMC (3:1) is a better formulation for the sustained released matrix tablets of theophylline.
- Published
- 2015
32. Efectos de la administración materna de teofilina en la organogénesis de las crías de ratones
- Author
-
Eulalia Fernández-Vallín Cárdenas, Lázara Karelia Montané Jaime, and Cristina Alfonso Zerquera
- Subjects
TEOFILINA ,ANOMALIAS INDUCIDAS POR DROGAS ,RATONES ,Medicine (General) ,R5-920 - Abstract
La teofilina, una metilxantina, fue evaluada para determinar la producción de anomalías esqueléticas y viscerales en crías de ratones BALB/c. La droga fue administrada del día 8 al 14 de la gestación, ambos incluidos, en dosis de 7,5 y 3 mg/kg por vía oral y parenteral; también se utilizó un grupo control al que se suministró suero fisiológico. A todos los grupos de crías se les realizó estudio visceral aplicando la técnica de Wilson y estudio esquelético con empleo de la técnica de Dawson. La teofilina produjo disminución del peso y la talla en fetos cuyas madres fueron tratadas con dosis de 7 mg/kg. No se encontró embriotoxicidad ni fetotoxicidad.
- Published
- 1995
33. Desarrollo y validación de un método analítico (HPLC RP) para la determinación de teofilina en plasma
- Author
-
Ponce D´León, Luisa Fernanda, Rojas, Jaime H., and Oviedo A., Alfredo
- Subjects
validation ,teofilina ,bioequivalence ,C18 ,bioequivalencia ,theophylline ,niveles sanguíneos ,detección UV ,biodisponibilidad ,lcsh:Chemistry ,lcsh:QD1-999 ,cafeína ,UV detection development ,HPLC ,blood levels ,bioavailability ,caffeine - Abstract
La teofilina es uno de los fármacos más conocidos para el tratamiento del asma y otros problemas crónicos respiratorios; en la actualidad, sus niveles sanguíneos se pueden relacionar con la eficacia de la terapia y con la aparición de efectos secundarios indeseables. En Colombiase comercializan alrededor de diez medicamentos de liberación programada, cuyo objetivo fundamental es mejorarel cumplimiento de la terapia y garantizar niveles sanguíneos estables; sin embargo, muchos de los problemas quepresenta su utilización se originan en la práctica inaceptable de intercambiar marcas sin conocer su bioequivalencia. En elpresente artículo se propone un nuevo método diseñado y validado para cuantifiLa teofilina es uno de los fármacosmás conocidos para el tratamiento del asma y otros problemas crónicos respiratorios; en la actualidad, sus niveles sanguíneos se pueden relacionar con la eficacia de la terapia y con la aparición de efectos secundarios indeseables. En Colombia se comercializan alrededor de diez medicamentos de liberación programada, cuyo objetivo fundamental es mejorar el cumplimiento de la terapia y garantizarniveles sanguíneos estables; sin embargo, muchos de los problemas que presenta su utilización se originan en lapráctica inaceptable de intercambiar marcas sin conocer su bioequivalencia. En el presente artículo se propone un nuevométodo diseñado y validado para cuantificar la teófilina en la sangre, y útil para el desarrollo de estudios de biodisponibilidad, bioequivalencia, monitoreo rutinariode niveles sanguíneos, y en química forense. El método propuesto presenta la ventaja de emplear una fase móvil menos contaminante y relativamente más económica,que en comparación facilita la limpieza del equipo y prolonga la vida útil de las columnas. El sistema cromatográficoen fase reversa, con detección espectrofotométricaa 266 nm, está constituido por una columna de octadecilsilano C 18 y una fase móvil conformada por metanolagua. Theophylline is a drug widely known for treating asthma and sorne other chronic respiratory diseases. At present time,the blood levels of drugs can be related with eficacy and side effects. There are around 10 drug products ofprogrammedrelease theophyIline forms, commercially available in Colombia. Most of the problems found in the utilization are caused by the non advisable interchange of theophyIline drug products, without any bioequivalency data for them. This study proposes a specific and validated analytical methodology for theophylline in biological fluid s including blood, which is useful for bioavailability and bioequivalencystudies, rutinary monitoring of theophylline blood levels and in forensic chemistry. This metodology has the advantage. touse a mobile phase les s contaminant and cheaper than others previously used. Besides, it makes easier the cleaning of the equipment and extend the useful life of the column. The chromatographic separation system by HPLC-RP, with spectrophotometric detection at 266 nm, ineludes an octadecylsilane C-18 column, and methanol/water as mobile phase.
- Published
- 2011
34. Evaluation of pectin-hpmc as compression coating: I - A study of the swelling properties of coated tablet
- Author
-
Douglas Abramoski Ribeiro, Naira Denise Zanardo, Gabriela Gomes Guimarães, Osvaldo Albuquerque Cavalcanti, and Gleyckson Itsuo Katsuki
- Subjects
Pharmacology ,Comprimidos^i1^savalia ,Comprimidos^i1^srevestimento por compres ,Fármacos^i1^slibera ,Drugs ,Pharmaceutical Science ,Comprimidos ,Pectina ,Pectin ,Tablets^i2^scompression coat ,Drugs^i2^srele ,Teofilina ,Theophylline ,Fármacos ,Tablets^i2^sevaluat ,Tablets - Abstract
Neste estudo, comprimidos de teofilina anidra foram revestidos através do processo de revestimento por compressão aplicando sistema binário pectina-HPMC. O método aplicado gerou comprimidos revestidos com características físicas adequadas aos padrões farmacopeicos. Foram avaliadas as características físicas dos comprimidos obtidos em diferentes proporções (80:20, 60:40, 50:50, 40:60, 20:80, 0:100) de pectina-HPMC respectivamente, e estabelecido o perfil de intumescimento desses sistemas nos fluidos de simulação gástrico (pH 1,2) e intestinal (pH 6,8). O método aplicado gerou a formação de comprimidos revestidos que apresentaram variação nos perfis de hidratação in vitro, entretanto, a análise estatística revelou que estas diferenças não foram significativas quando comparadas entre si. O sistema formado apresenta elevada expectativa sobre o gerenciamento da liberação de fármacos, todavia, só a partir do teste de dissolução que constitui a segunda etapa deste projeto poderemos definir qual das formulações propostas será mais eficaz no controle da cinética de liberação. In this study, core tablets of dry theophylline were compressed coated using the system pectin-HPMC for controlled drug delivery. The methodology applied produced coated tablets with suitable physical characteristics according to Brazil Pharmacopeia 4th edition. The physical properties were evaluated for different ratios (80:20, 60:40, 50:50, 40:60, 20:80, 0:100) of pectin-HPMC, respectively, and the swelling test was carried out in simulated gastric fluid (pH 1.2) and in simulated intestinal fluid (pH 6.8). The method applied gave origin to coated tablets with high expectation in the kinetics control of drug release. From the statistics analyses of the results obtained, it was observed that results were not significant between different ratios.
- Published
- 2008
35. Avaliação da pectina-HPMC no processo de revestimento por compressão: I - Estudo da propriedade de intumescimento em núcleos revestidos Evaluation of pectin-hpmc as compression coating: I - A study of the swelling properties of coated tablet
- Author
-
Gabriela Gomes Guimarães, Gleyckson Itsuo Katsuki, Naira Denise Zanardo, Douglas Abramoski Ribeiro, and Osvaldo Albuquerque Cavalcanti
- Subjects
lcsh:Pharmacy and materia medica ,Teofilina ,Theophylline ,Fármacos ,lcsh:R ,Drugs ,lcsh:Medicine ,lcsh:RS1-441 ,Comprimidos ,Pectina ,Pectin ,Tablets - Abstract
Neste estudo, comprimidos de teofilina anidra foram revestidos através do processo de revestimento por compressão aplicando sistema binário pectina-HPMC. O método aplicado gerou comprimidos revestidos com características físicas adequadas aos padrões farmacopeicos. Foram avaliadas as características físicas dos comprimidos obtidos em diferentes proporções (80:20, 60:40, 50:50, 40:60, 20:80, 0:100) de pectina-HPMC respectivamente, e estabelecido o perfil de intumescimento desses sistemas nos fluidos de simulação gástrico (pH 1,2) e intestinal (pH 6,8). O método aplicado gerou a formação de comprimidos revestidos que apresentaram variação nos perfis de hidratação in vitro, entretanto, a análise estatística revelou que estas diferenças não foram significativas quando comparadas entre si. O sistema formado apresenta elevada expectativa sobre o gerenciamento da liberação de fármacos, todavia, só a partir do teste de dissolução que constitui a segunda etapa deste projeto poderemos definir qual das formulações propostas será mais eficaz no controle da cinética de liberação.In this study, core tablets of dry theophylline were compressed coated using the system pectin-HPMC for controlled drug delivery. The methodology applied produced coated tablets with suitable physical characteristics according to Brazil Pharmacopeia 4th edition. The physical properties were evaluated for different ratios (80:20, 60:40, 50:50, 40:60, 20:80, 0:100) of pectin-HPMC, respectively, and the swelling test was carried out in simulated gastric fluid (pH 1.2) and in simulated intestinal fluid (pH 6.8). The method applied gave origin to coated tablets with high expectation in the kinetics control of drug release. From the statistics analyses of the results obtained, it was observed that results were not significant between different ratios.
- Published
- 2008
36. Influence of cellulose polymers type on in vitro controlled release tablets containing theophylline Desenvolvimento e avaliação de comprimidos matriciais de teofilina baseados em ésteres da celulose
- Author
-
Evelyn Ojoe, Edna Mitie Miyauchi, Telma Mary Kaneko, Maria Valéria Rolbes Velasco, and Vladi Olga Consiglieri
- Subjects
Hidroxipropilmetilcelulose ,lcsh:R ,Matrizes ,lcsh:Medicine ,lcsh:RS1-441 ,Liberação modificada ,Etilcelulose ,Ethylcellulose ,lcsh:Pharmacy and materia medica ,Teofilina ,Matrices ,Theophylline ,Hydroxypropylmethylcellulose ,Controlled release - Abstract
In this study, the effect of ethylcellulose (EC) and 6 types of hydroxypropylmethylcellulose (Methocel® K100M, K100MPRCR, K15MPRCR, K4MPRCR, K4M PR and E4MCR) on release profile of theophylline from matrix tablets was evaluated. Formulations tablets were prepared by either wet granulation or direct compression technique. The tablets were evaluated for physical characteristics and in vitro release of drug was performed as described in USP 30 ed. (Test 3). All formulations with cellulose polymer produced tablets easily and with physicals characteristics in accordance with official limits. Drug dissolution tests showed that formulations with 15% of Methocel® K4MPR, 15% of Methocel® K4MPRCR and 30% of Ethocel® N10STD, obtained by direct compression method, complied with official specifications, in terms of release profile and diffusion was the main mechanism involved in theophylline delivery.Os efeitos das variáveis das formulações na liberação da teofilina a partir da hidroxipropilmetilcelulose (HPMC) e etilcelulose (EC) em comprimidos matriciais foram estudados. Formulações de comprimidos foram preparadas pelos métodos da granulação úmida ou compressão direta usando diferentes viscosidades de HPMC. Propriedades físico-químicas dos comprimidos e liberação do fármaco foram estudadas conforme dissolução descrita no Teste 3 da Farmacopéia Americana 30ed. Ensaios "in vitro" mostraram que as formulações com 15% de Methocel® K4MPR, 15% de Methocel® K4MPRCR e 30% de Ethocel® N10STD obtidas por compressão direta apresentaram bom perfil de liberação de teofilina e a difusão foi o principal mecanismo envolvido na liberação.
- Published
- 2007
37. Development and in vitro evaluation of extended-release theophylline matrix capsules Desenvolvimento e avaliação in vitro de cápsulas de teofilina de liberação prolongada
- Author
-
Vanessa Alves Pinheiro, Telma Mary Kaneko, Maria Valéria Robles Velasco, and Vladi Olga Consiglieri
- Subjects
lcsh:Pharmacy and materia medica ,Teofilina ,Theophylline ,lcsh:R ,Cápsulas ,Liberação prolongada ,lcsh:Medicine ,lcsh:RS1-441 ,Capsules ,Extended-release ,Dissolução ,Dissolution - Abstract
Polymers like cellulose (MethocelTM K100MPRCR, K15MPRCR and E4MCR) at different proportions (15-35%) were used to slow the release of theophylline (100 mg) from capsules. Volumetric method for powder filling capsules was used to prepare the capsules. Drug release from capsules was performed using apparatus 1, at 100 rpm and 900 mL of intestinal medium without enzymes (pH 7.5), at 37 °C, following the USP 28th ed. (Test 8). Dissolution profiles were compared to two batches of commercial extended-release capsules. Capsules compounded with 35% (wt/wt) of MethocelTM E4MCR showed dissolution profile according to the official especifications. Similar results were reproduced with other ten compounded batches. Commercial extended-release capsules containing theophylline pellets (100 mg) showed quick drug release when submitted to the same test, indicating that, in these conditions, the capsules did not show prolonged release. Mathematical models like zero-order, first-order and Higuchi were applied in kinetic studies of theophylline release from the compounded capsules. Polymers were efficient to control the release of theophylline in capsules involving diffusion and erosion as mechanisms, and that first-order model was the best fitted one for theophylline matrix capsules. These results support that compounded extended-release capsules can be prepared, since the drug release tests can be done.Cápsulas de liberação modificada contendo 100 mg de teofilina foram preparadas com polímeros derivados da celulose (Methocel® K100MPRCR, K15MPRCR e E4MCR) em diferentes concentrações, 15-35%, empregando-se o método volumétrico. Estudos de liberação do fármaco foram realizados de acordo com a Farmacopéia Americana 28 ed., (Teste 8), empregando aparato 1, rotação de 100 rpm e temperatura de 37 ºC em 900 mL de meio fluido intestinal sem enzimas (pH 7,5). Os perfis de dissolução foram comparados ao de duas especialidades farmacêuticas comerciais. A formulação, com 35% de Methocel® E4MCR, evidenciou perfis de liberação de acordo com as especificações e os resultados foram reprodutíveis para 10 lotes manipulados com a mesma formulação. As cápsulas comerciais de liberação prolongada contendo 100 mg de teofilina (microgrânulos), submetidas ao mesmo ensaio, apresentaram rápida liberação do fármaco, indicando que a liberação não é fator limitante para a absorção. Avaliou-se a cinética de liberação do fármaco empregando os modelos matemáticos de ordem zero, primeira ordem e Higuchi. Conclui-se que as matrizes obtidas foram capazes de modular a liberação, envolvendo os mecanismos de difusão e erosão, prevalecendo o modelo de primeira ordem e que as cápsulas de liberação modificada podem ser manipuladas, desde que testes de liberação sejam realizados.
- Published
- 2007
38. Avaliação da Goma Guar no desenvolvimento de comprimidos matriciais de liberação controlada de teofilina
- Author
-
Tamara Gonçalves de Araújo, Rosana de Sousa Campos, Juliana Fernandes Pereira, Anaiara Silva Machado, and Edilene Gadelha de Oliveira
- Subjects
teofilina ,Chromatography ,Guar gum ,Materials science ,liberação controlada ,Organic Chemistry ,Mineralogy ,Friability ,lcsh:Chemical technology ,Controlled release ,Matrix (chemical analysis) ,Distilled water ,medicine ,comprimidos ,Chemical Engineering (miscellaneous) ,Goma Guar ,Dissolution testing ,Theophylline ,lcsh:TP1-1185 ,Swelling ,medicine.symptom ,medicine.drug - Abstract
Resumo O objetivo desse estudo foi formular e avaliar comprimidos de liberação controlada. Comprimidos de liberação controlada de teofilina foram preparadas pelo método de compressão direta usando dois polímeros como, o HPMC K 100M (polímero hidrofílico) e a Goma Guar (Polímero natural), isolado ou em mistura (GG:HPMC 3:1) e GG:HPMC 1:3). Os comprimidos foram caracterizados através do peso médio, diâmetro, altura, dureza, friabilidade. Todos os resultados estiveram em conformidade com os limites aceitáveis. O ensaio de intumescimento foi realizado em água destilada durante 4 horas, sendo determinado pela diferença de peso do comprimido seco e intumescido. O ensaio de dissolução foi realizado em água destilada (900 mL, 37 ± 0,5ºC, 50 rpm, aparato II) durante 8 horas. Os resultados demonstraram que a Goma guar isolada não possui capacidade de retardar a liberação da teofilina por 8 horas. Comprimidos matriciais contendo GG:HPMC (3:1) apresentaram um melhor controle de liberação da teofilina.
- Published
- 2015
39. Requerimiento dieléctrico de la teofilina en un sistema ternario para su posterior optimización de la formulación oral en el Laboratorio Mauricio Díaz Müller, UNAN-León
- Author
-
Canales-Ruiz, Ronal José
- Subjects
Health Economics and Policy ,Teofilina ,soluciones ,requerimiento dieléctrico ,sistema ternario - Abstract
El Laboratorios “Mauricio Díaz Müller”, actualmente está renovando los registros sanitarios de sus productos, exclusivamente en la línea de líquidos orales, entre ellos la Teofilina 80mg/15ml Elixir. Este producto fue registrado en noviembre del año 2004, cumpliendo con los requisitos reglamentarios de esa época. Actualmente los requisitos reglamentarios vigentes para renovar este producto han sufrido cambios, uno de ellos es que, los medicamentos indicados para niños no deben contener alcohol y lo otro es que la especificación del producto el pH cambió, según referencia bibliográfica actual. En el presente estudio se consideró utilizar la técnica de cosolvencia para modificar la solubilidad de la teofilina anhidra, para luego formular la Teofilina 80mg/15ml solución oral, elaborado sin alcohol. En principio se identificó el requerimiento dieléctrico del principio activo, en un sistema ternario de solventes acuomiscibles a distintas concentraciones, se elaboraron 4 ensayos de Teofilina 80 mg/15 ml solución oral a los cuales se les determinaron las siguientes variables cuali-cuantitativas: al principio activo: solubilidad acuosa, al producto: las características organolépticas, identificación, cuantificación y pH. Con este estudio se logró incrementar la solubilidad del P.A. en un 142 % en el sistema ternario, durante la investigación se monitoreo el cumplimiento de las variables en estudio.
- Published
- 2015
- Full Text
- View/download PDF
40. Una propuesta para aumentar el número de puntos de soporte en un diseño D-óptimo bayesiano en un modelo de dos compartimientos
- Author
-
Víctor Ignacio López Ríos, Cristian Fernando Tellez, and Diego Fernando Lemus
- Subjects
Environmental Engineering ,diseño D-óptimo bayesiano ,diseño D-óptimo bayesiano, modelos bicompartimentales, teofilina ,teofilina ,modelos bicompartimentales - Abstract
Se implementa la metodología propuesta por Tellez & López-Ríos (2013) para el aumento del número de puntos de soporte en un diseño D-óptimo bayesiano en modelos de dos compartimientos. Se consideran los datos presentados en Fresen (1986), referido en Atkinson et al. (2007), donde se modela la relaci ́on entre la cantidad de Teofilina inoculada en la sangre de un potro y el tiempo de reacción de dicho medicamento a partir de un modelo de dos compartimientos. Los resultados anal ́ıticos obtenidos en el trabajo enunciado previamente se validan y se muestra el buen comportamiento de la metodología en términos de potencia y eficiencia al compararlos con otros diseños disponibles en la literatura. The methodology proposed by Tellez & L´opez-R´ıos (2013) for increasing the number of support points in a design is implemented in a D-optimal Bayesian design by two-compartment models. Data presented on Fresen(1986) are considered, referenced on Atkinson et al. (2007), where they modeled the ratio between Theophylline inoculated into the blood of a pony and the reaction time of the drug from a two-compartment model. The analytical results obtained in the paper previously validated and good behavior of the method is shown in terms of power and efficiency when compared to other designs available in the literature.
- Published
- 2014
41. Una propuesta para aumentar el número de puntos de soporte en un diseño D-óptimo bayesiano en un modelo de dos compartimientos
- Author
-
Tellez, Cristian, Ríos, Víctor Ignacio López, and Lemus, Diego Fernando
- Subjects
diseño D-óptimo bayesiano ,teofilina ,modelos bicompartimentales - Abstract
The methodology proposed by Tellez & L´opez-R´ıos (2013) for increasing the number of support points in a design is implemented in a D-optimal Bayesian design by two-compartment models. Data presented on Fresen(1986) are considered, referenced on Atkinson et al. (2007), where they modeled the ratio between Theophylline inoculated into the blood of a pony and the reaction time of the drug from a two-compartment model. The analytical results obtained in the paper previously validated and good behavior of the method is shown in terms of power and efficiency when compared to other designs available in the literature. Se implementa la metodología propuesta por Tellez & López-Ríos (2013) para el aumento del número de puntos de soporte en un diseño D-óptimo bayesiano en modelos de dos compartimientos. Se consideran los datos presentados en Fresen (1986), referido en Atkinson et al. (2007), donde se modela la relaci ́on entre la cantidad de Teofilina inoculada en la sangre de un potro y el tiempo de reacción de dicho medicamento a partir de un modelo de dos compartimientos. Los resultados anal ́ıticos obtenidos en el trabajo enunciado previamente se validan y se muestra el buen comportamiento de la metodología en términos de potencia y eficiencia al compararlos con otros diseños disponibles en la literatura.
- Published
- 2014
42. Formulation and in vitro evaluation of theophylline-Eudragit® sustained-release tablets Desenvolvimento e avaliação in vitro de comprimidos de liberação prolongada de teofilina preparados com Eudragit®
- Author
-
Evelyn Ojoe, Edna Mitie Miyauchi, Tais Cobo Viviani, and Vladi Olga Consiglieri
- Subjects
teofilina ,Methacrylic acid esters ,lcsh:Pharmacy and materia medica ,ésteres do ácido metacrílico ,Matrices ,Theophylline ,lcsh:R ,liberação prolongada ,lcsh:Medicine ,lcsh:RS1-441 ,matrizes ,Sustained-release ,Dissolution - Abstract
Tablets containing theophylline (66.67%) based on a Eudragit® RS 30D and NE 30D matrices containing 10% to 30% of either of the polymer were produced by compression method. The influence of the different proportions of methacrylic esters, the use of lactose and tribasic calcium phosphate as diluents and also the effects of the addition of magnesium stearate as a hydrophobic agent lubricant on the theophylline release, were studied. Physicochemical analyses and drug content was evaluated. In vitro drug release studies were carried out in simulated gastric fluid without pepsin (pH1.2) and simulated intestinal fluid without pancreatin (pH7.5). A relatively prolonged release of theophylline from the polymer matrices for a 7 hr-release period was detected. Magnesium stearate at 0.5% and Eudragit® NE 30D at 10% was considered a better sustained-release matrix compressed theophylline tablets comparing with Eudragit® RS 30D in the same conditions (USP). Results from physicochemical analyses were in accordance with specifications. The release patterns were analyzed from the viewpoint of square-root of time and as a first-order, zero-order kinetics, and Higuchi. Additionally, half-life of release (Td50%) and dissolution rates (kd) were calculated. Higuchi was the model that better fitted theophylline kinetic, and diffusion controlled was involved.Comprimidos contendo teofilina (66.67%) e polímeros de Eudragit® NE 30D e RS 30D entre 10 e 30% foram produzidos por compressão. A influência das diferentes proporções de ésteres do ácido metacrílico, uso da lactose e fosfato de cálcio tribásico como diluente, bem como os efeitos da adição de estearato de magnésio como agente lubrificante hidrofóbico na liberação da teofilina foram estudados. Análises físico-químicas e teor de fármaco foram avaliados. Estudos da liberação do fármaco in vitro foram conduzidos em fluido gástrico simulado (pH 1,2) e fluido intestinal simulado sem pancreatina (pH 7,5). Observou-se liberação prolongada relativa de teofilina partindo de polímeros matriciais, em 7 horas de dissolução. Estearato de magnésio a 0,5% e de Eudragit® NE 30D a 10% foi considerado o sistema de liberação adequado para comprimidos matriciais comparado com de Eudragit® RS 30D nas mesmas condições (USP). Os resultados das análises físico-químicas apresentaram-se dentro das especificações. Modelos matemáticos de ordem zero, primeira ordem e Higuchi foram aplicados para estudar a liberação de teofilina nos comprimidos. Adicionalmente, foram calculadas a meia-vida (Td50%) e a velocidade de dissolução (kd). O modelo de liberação de Higuchi foi o que melhor representou a liberação do fármaco nos comprimidos, sendo demonstrado que o principal mecanismo de liberação foi a difusão.
- Published
- 2005
43. Efecto de metilxantinas sobre la criopreservación de semen de toros de la raza criolla argentina
- Author
-
Tovío luna, Néstor Isaías, Robayo Coral, Juliana, Tovío luna, Néstor Isaías, and Robayo Coral, Juliana
- Abstract
El objetivo consistió en evaluar la utilización de cafeína y teofilina sobre la criopreservación de semen de toros de la raza criolla Argentina, estudiando efectos en la motilidad, vigor espermático, y el pH en el semen. Se utilizaron 5 machos adultos, clínicamente sanos y aptos reproductivamente. Se utilizaron 5 diluyentes T1 (testigo): lactosa 11%, T2: cafeína 6 milimoles (mmol), T3: cafeína 10 mmol., T4: teofilina 6 mmol, T5: teofilina 10 mmol. Las muestras de semen se obtuvieron con Vagina Artificial. A cada muestra se le realizaron evaluaciones macroscópicas y microscópicas. Luego congelaron y almacenaron en nitrógeno liquido para su posterior observación, para lo cual se descongelan 5 pajillas del mismo toro en baño María a 37 ºC, luego se realiza la dilución en una proporción 3:1 (Diluyente: semen) de cada pajilla en un tratamiento diferente, a continuación se mantiene en baño María a 37ºC durante el tiempo de observación. La observación se realiza a los 0, 30, 60, 90 y 120 minutospost descongelación, evaluando la motilidad y el vigor espermático; el pH se midió al tiempo 0 y 120. Los datos de motilidad y vigor obtenidos no presentaron estadísticamente diferencia significativa (p < = 0,05) a los 30, 60y 120 minutos, la cafeína 6 mmol. presento efecto (0 min) y la Teofilina a los 90 min; en cuanto al vigor presento efecto a los 60 min la teofilina 10 mmol., el pH disminuyo los 120 minutos de observación en las muestras que contenían metilxantinas.
- Published
- 2015
44. Thermoanalytical study of purine derivatives compounds
- Author
-
Massao Ionashiro, Marcelo Kobelnik, G. F. C. Sotelo, Egon Schnitzler, Gilbert Bannach, Universidade Estadual de Ponta Grossa (UEPG), Universidade Estadual Paulista (UNESP), and Universidade Estadual Paulista (Unesp)
- Subjects
teofilina ,Purine ,Thermal decomposition ,General Physics and Astronomy ,Infrared spectroscopy ,ácido úrico ,General Chemistry ,theophylline ,DTA ,aminophylline ,chemistry.chemical_compound ,uric acid ,chemistry ,cafeína ,medicine ,Uric acid ,Organic chemistry ,TG ,Theophylline ,Thermal stability ,aminofilina ,Thermal analysis ,Derivative (chemistry) ,caffeine ,medicine.drug - Abstract
Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:49:13Z No. of bitstreams: 1 S0100-46702004000100009.pdf: 266220 bytes, checksum: c8843b94122a9dff36327a1b3f58c6fd (MD5) Made available in DSpace on 2013-08-22T18:49:13Z (GMT). No. of bitstreams: 1 S0100-46702004000100009.pdf: 266220 bytes, checksum: c8843b94122a9dff36327a1b3f58c6fd (MD5) Previous issue date: 2004-01-01 Made available in DSpace on 2013-09-30T19:39:28Z (GMT). No. of bitstreams: 2 S0100-46702004000100009.pdf: 266220 bytes, checksum: c8843b94122a9dff36327a1b3f58c6fd (MD5) S0100-46702004000100009.pdf.txt: 10323 bytes, checksum: be5760d83a2ecbe78eb64aebff673508 (MD5) Previous issue date: 2004-01-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:26:50Z No. of bitstreams: 2 S0100-46702004000100009.pdf: 266220 bytes, checksum: c8843b94122a9dff36327a1b3f58c6fd (MD5) S0100-46702004000100009.pdf.txt: 10323 bytes, checksum: be5760d83a2ecbe78eb64aebff673508 (MD5) Made available in DSpace on 2014-05-20T13:26:50Z (GMT). No. of bitstreams: 2 S0100-46702004000100009.pdf: 266220 bytes, checksum: c8843b94122a9dff36327a1b3f58c6fd (MD5) S0100-46702004000100009.pdf.txt: 10323 bytes, checksum: be5760d83a2ecbe78eb64aebff673508 (MD5) Previous issue date: 2004-01-01 Os métodos térmicos em análises estão sendo atualmente muito utilizados nas investigações cientificas. Neste trabalho a termogravimetria-análise térmica diferencial simultânea (TG-DTA), difratometria de raios X pelo método do pó, espectroscopia de absorção na região do infravermelho foram utilizadas para estudar os compostos derivados da purina. Sendo estes: aminofilina. teofilina, cafeína e ácido úrico. Os resultados forneceram informações com respeito à estabilidade térmica e decomposição térmica sobre esses compostos. Thermal methods of analysis are now used in a very large range of scientific investigations. In this work simultaneous thermogravimetry-differential thermal analysis (TG-DTA), X-Ray powder diffractometry and infrared spectroscopy were used to study the derivative compounds of purine, i. e. aminophylline, theophylline, caffeine and uric acid. The results led to informations about the thermal stability and thermal decomposition of these compounds. Universidade Estadual de Ponta Grossa Departamento de Química Universidade Estadual de Ponta Grossa Departamento de Engenharia de Materiais Universidade Estadual Paulista Instituto de Química Universidade Estadual Paulista Instituto de Química
- Published
- 2004
45. Thermoanalytical study of purine derivatives compounds Estudo termoanalítico de compostos derivados da purina
- Author
-
E. Schnitzler, M. Kobelnik, G. F. C. Sotelo, G. Bannach, and M. Ionashiro
- Subjects
teofilina ,lcsh:Chemistry ,uric acid ,lcsh:QD1-999 ,cafeína ,TG ,aminofilina ,ácido úrico ,DTA ,theophylline ,aminophylline ,caffeine - Abstract
Thermal methods of analysis are now used in a very large range of scientific investigations. In this work simultaneous thermogravimetry-differential thermal analysis (TG-DTA), X-Ray powder diffractometry and infrared spectroscopy were used to study the derivative compounds of purine, i. e. aminophylline, theophylline, caffeine and uric acid. The results led to informations about the thermal stability and thermal decomposition of these compounds.Os métodos térmicos em análises estão sendo atualmente muito utilizados nas investigações cientificas. Neste trabalho a termogravimetria-análise térmica diferencial simultânea (TG-DTA), difratometria de raios X pelo método do pó, espectroscopia de absorção na região do infravermelho foram utilizadas para estudar os compostos derivados da purina. Sendo estes: aminofilina. teofilina, cafeína e ácido úrico. Os resultados forneceram informações com respeito à estabilidade térmica e decomposição térmica sobre esses compostos.
- Published
- 2004
46. Simultaneous determination of theobromine, theophylline and caffeine in teas by high performance liquid chromatography
- Author
-
Neura Bragagnolo and Adriana Barreto Alves
- Subjects
Pharmacology ,Tea ,CLAE ,Teobromina ,Pharmaceutical Science ,Alcalóides ,Teofilina ,Cafeína ,Chás ,Alkaloids ,Theophylline ,Caffeine ,Theobromine ,HPLC - Abstract
Para a realização deste trabalho, foram analisadas 10 amostras de diferentes tipos e marcas de chás com o objetivo de se quantificar teobromina, teofilina e cafeína simultaneamente. Para tanto, otimizou-se técnica de cromatografia líquida de alta eficiência (CLAE) baseada na ISO 10095 (1992), utilizando-se coluna Inertsil ODS-3 (150x4 mm, 5 mm), fase móvel de ácido acético 1% + acetonitrila (95:5, v/v), fluxo de 1 mL/min e detector de UV/VIS ajustado em 273 nm. Os resultados de cafeína obtidos por esse método foram comparados com os obtidos por um método espectrofotométrico de acordo com Schormüller (1970). Não houve diferença significativa nos resultados de cafeína nas amostras de chá preto obtidos pelos dois métodos. As amostras de chá preto foram as que apresentaram maiores teores de teobromina e cafeína e nenhuma das amostras apresentou quantidades significativas de teofilina. To carry out this study, 10 samples of different kinds and brands of teas were analyzed with the purpose of quantifying simultaneously theobromine, theophylline and caffeine. For this, high performance liquid chromatography (HPLC) was used based on ISO 10095 (1992). The conditions were: a reversed phase column (Inertisil ODS-3, 150x4 mm, 5 mm); acetic acid 1% + acetonitrile (95:5, v/v) as mobile phase; flow of 1 ml/min and UV-VIS detector set at 273 nm. The results of caffeine obtained by this method were compared with those using a spectrophotometric method according to Schormüller (1970). In the case of black tea, no difference was observed in the caffeine, by both methods. The samples of black tea had the highest amounts of theobromine and caffeine and no sample had a significant amount of theophylline.
- Published
- 2002
47. Determinação simultânea de teobromina, teofilina e cafeína em chás por cromatografia líquida de alta eficiência Simultaneous determination of theobromine, theophylline and caffeine in teas by high performance liquid chromatography
- Author
-
Adriana Barreto Alves and Neura Bragagnolo
- Subjects
Tea ,lcsh:R ,CLAE ,Teobromina ,lcsh:Medicine ,lcsh:RS1-441 ,Alcalóides ,lcsh:Pharmacy and materia medica ,Teofilina ,Cafeína ,Chás ,Alkaloids ,Theophylline ,Caffeine ,Theobromine ,HPLC - Abstract
Para a realização deste trabalho, foram analisadas 10 amostras de diferentes tipos e marcas de chás com o objetivo de se quantificar teobromina, teofilina e cafeína simultaneamente. Para tanto, otimizou-se técnica de cromatografia líquida de alta eficiência (CLAE) baseada na ISO 10095 (1992), utilizando-se coluna Inertsil ODS-3 (150x4 mm, 5 mm), fase móvel de ácido acético 1% + acetonitrila (95:5, v/v), fluxo de 1 mL/min e detector de UV/VIS ajustado em 273 nm. Os resultados de cafeína obtidos por esse método foram comparados com os obtidos por um método espectrofotométrico de acordo com Schormüller (1970). Não houve diferença significativa nos resultados de cafeína nas amostras de chá preto obtidos pelos dois métodos. As amostras de chá preto foram as que apresentaram maiores teores de teobromina e cafeína e nenhuma das amostras apresentou quantidades significativas de teofilina.To carry out this study, 10 samples of different kinds and brands of teas were analyzed with the purpose of quantifying simultaneously theobromine, theophylline and caffeine. For this, high performance liquid chromatography (HPLC) was used based on ISO 10095 (1992). The conditions were: a reversed phase column (Inertisil ODS-3, 150x4 mm, 5 mm); acetic acid 1% + acetonitrile (95:5, v/v) as mobile phase; flow of 1 ml/min and UV-VIS detector set at 273 nm. The results of caffeine obtained by this method were compared with those using a spectrophotometric method according to Schormüller (1970). In the case of black tea, no difference was observed in the caffeine, by both methods. The samples of black tea had the highest amounts of theobromine and caffeine and no sample had a significant amount of theophylline.
- Published
- 2002
48. Biodisponibilidad relativa de un preparado de Teofilina expendido en el mercado nacional
- Author
-
Leiva P, Ruiz M, M. Andresen., H. Serrat., and Prat G
- Subjects
lcsh:R5-920 ,Teofilina ,Disponibilidad Biológica ,lcsh:R ,lcsh:Medicine ,General Medicine ,lcsh:Medicine (General) - Abstract
Sin resumen
- Published
- 2017
49. Prueba comparativa de uniformidad de contenido en tabletas de teofilina (150 mg/tab) de dos casas farmacéuticas en Costa Rica
- Author
-
Anderson Vargas-Vargas, Kevin Morales-Alfaro, Alfonso Rojas-Hernández, and Esteban Pérez-López
- Subjects
spectroscopy ,uniformidad de contenido ,Relative standard deviation ,lcsh:Technology ,Industrial and Manufacturing Engineering ,law.invention ,Teofilina ,absorbance ,Theophylline ,law ,espectroscopía ,Medicine ,In patient ,principio activo ,absorbancia ,active ingredient ,Active ingredient ,Traditional medicine ,lcsh:T ,business.industry ,tablets ,Advertising ,content uniformity ,tabletas ,Pharmacopoeia ,business ,medicine.drug - Abstract
Dada la importancia del medicamento denominado teofilina para su uso en pacientes con problemas de asma y su alto consumo en Costa Rica, se eligió el producto en tabletas de 150 mg de teofilina de una casa farmacéutica que lo produce y distribuye en forma genérica, junto con el que fabrica la Caja Costarricense de Seguro Social (CCSS) en la misma dosis. Se realizó el estudio comparativo de la prueba de uniformidad de contenido para las tabletas de teofilina de 150 mg de la casa farmacéutica LISAN y las fabricadas por la CCSS. La prueba de uniformidad de contenido analíticamente se fundamentó en la absorción y cuantificación del ingrediente activo teofilina a 272 nm para 10 muestras de cada casa farmacéutica, mediante el uso de un espectrofotómetro UV/Vis, empleando como disolvente agua destilada. Se probó un método selectivo, exacto y preciso y se obtuvo como resultado que todas las dosis ensayadas para cada fabricante se encuentran en el rango de 100% a 110%, con respecto a lo etiquetado sobre el principio activo en las tabletas y con un desvío relativo no mayor al 2,5%, cumpliendo holgadamente con lo establecido por la Farmacopea de Estados Unidos para la prueba de uniformidad de contenido. Given the importance of the drug called theophylline, for use in patients with asthma, and given the high consumption of this drug in our country, we chose the product in tablets of 150 mg of theophylline from a pharmaceutical company that produces and distributes in the form generic that drug, along with manufactured by the Social Security Fund (CCSS) at the same dose of the same drug. We performed a comparative study of content uniformity test for theophylline tablets 150 mg, pharmaceutical house LISAN and the Social Security Fund. The content uniformity test was based on the absorption of the active ingredient and theophylline quantification at 272 nm for 10 samples of each house pharmaceutical, by using a UV/Vis, using distilled water as solvent. Proved that the method is selective, accurate and precise, and as a result was obtained that at all doses tested for each manufacturer, are in the range of 100% to 110%, with respect to labeling of the active ingredient in the tablets and with a relative deviation of no more than 2,5%, complying with the provisions of the Pharmacopoeia of the United States, to test for uniformity of content.
- Published
- 2014
50. Prueba comparativa de uniformidad de contenido en tabletas de teofilina (150 mg/tab) de dos casas farmacéuticas en Costa Rica
- Author
-
Pérez-López, Esteban, Morales-Alfaro, Kevin, Rojas-Hernández, Alfonso, and Vargas-Vargas, Anderson
- Subjects
Theophylline ,content uniformity ,active ingredient ,tablets ,absorbance ,spectroscopy ,Teofilina ,uniformidad de contenido ,principio activo ,tabletas ,absorbancia ,espectroscopía - Abstract
Given the importance of the drug called theophylline, for use in patients with asthma, and given the high consumption of this drug in our country, we chose the product in tablets of 150 mg of theophylline from a pharmaceutical company that produces and distributes in the form generic that drug, along with manufactured by the Social Security Fund (CCSS) at the same dose of the same drug. We performed a comparative study of content uniformity test for theophylline tablets 150 mg, pharmaceutical house LISAN and the Social Security Fund. The content uniformity test was based on the absorption of the active ingredient and theophylline quantification at 272 nm for 10 samples of each house pharmaceutical, by using a UV/Vis, using distilled water as solvent. Proved that the method is selective, accurate and precise, and as a result was obtained that at all doses tested for each manufacturer, are in the range of 100% to 110%, with respect to labeling of the active ingredient in the tablets and with a relative deviation of no more than 2,5%, complying with the provisions of the Pharmacopoeia of the United States, to test for uniformity of content. Dada la importancia del medicamento denominado teofilina para su uso en pacientes con problemas de asma y su alto consumo en Costa Rica, se eligió el producto en tabletas de 150 mg de teofilina de una casa farmacéutica que lo produce y distribuye en forma genérica, junto con el que fabrica la Caja Costarricense de Seguro Social (CCSS) en la misma dosis. Se realizó el estudio comparativo de la prueba de uniformidad de contenido para las tabletas de teofilina de 150 mg de la casa farmacéutica LISAN y las fabricadas por la CCSS. La prueba de uniformidad de contenido analíticamente se fundamentó en la absorción y cuantificación del ingrediente activo teofilina a 272 nm para 10 muestras de cada casa farmacéutica, mediante el uso de un espectrofotómetro UV/Vis, empleando como disolvente agua destilada. Se probó un método selectivo, exacto y preciso y se obtuvo como resultado que todas las dosis ensayadas para cada fabricante se encuentran en el rango de 100% a 110%, con respecto a lo etiquetado sobre el principio activo en las tabletas y con un desvío relativo no mayor al 2,5%, cumpliendo holgadamente con lo establecido por la Farmacopea de Estados Unidos para la prueba de uniformidad de contenido.
- Published
- 2014
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.